Scholars@Duke
David Masao Ota

David Masao Ota

Professor of Surgery
Surgical Oncology
david.ota@duke.edu
Box 3850 Med Ctr, Durham, NC 27710
2200 W Main St, Durham, NC 27705

Selected Publications

Genomic characterization of HER2-positive breast cancer and response to neoadjuvant trastuzumab and chemotherapy-results from the ACOSOG Z1041 (Alliance) trial.

Journal Article Ann Oncol · May 1, 2017 BACKGROUND: HER2 (ERBB2) gene amplification and its corresponding overexpression are present in 15-30% of invasive breast cancers. While HER2-targeted agents are effective treatments, resistance remains a major cause of death. The American College of Surge ... Full text Link to item Cite

Ki67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance).

Journal Article J Clin Oncol · April 1, 2017 Purpose To determine the pathologic complete response (pCR) rate in estrogen receptor (ER) -positive primary breast cancer triaged to chemotherapy when the protein encoded by the MKI67 gene (Ki67) level was > 10% after 2 to 4 weeks of neoadjuvant aromatase ... Full text Link to item Cite

Comprehensive genomic studies: emerging regulatory, strategic, and quality assurance challenges for biorepositories.

Journal Article Am J Clin Pathol · July 2012 As part of the molecular revolution sweeping medicine, comprehensive genomic studies are adding powerful dimensions to medical research. However, their power exposes new regulatory, strategic, and quality assurance challenges for biorepositories. A key iss ... Full text Link to item Cite

Microscopically positive margins for primary gastrointestinal stromal tumors: analysis of risk factors and tumor recurrence.

Journal Article J Am Coll Surg · July 2012 BACKGROUND: Little is known about the outcomes of patients with microscopically positive (R1) resections for primary gastrointestinal stromal tumors (GIST) because existing retrospective series contain small numbers of patients. The objective of this study ... Full text Link to item Cite

Whole-genome analysis informs breast cancer response to aromatase inhibition.

Journal Article Nature · June 10, 2012 To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two studies of neoadjuvant aromatase inhibitor therapy by massively parallel ... Full text Link to item Cite

Whole genome sequencing to characterize luminal-type breast cancer

Conference JOURNAL OF CLINICAL ONCOLOGY · May 20, 2012 Link to item Cite

Features associated with successful recruitment of diverse patients onto cancer clinical trials: report from the American College of Surgeons Oncology Group.

Journal Article Ann Surg Oncol · December 2011 BACKGROUND: The clinical trials mechanism of standardized treatment and follow-up for cancer patients with similar stages and patterns of disease is the most powerful approach available for evaluating the efficacy of novel therapies, and clinical trial par ... Full text Link to item Cite

American College of Surgeons Oncology Group and the community surgeon.

Journal Article Surg Oncol Clin N Am · July 2011 The American College of Surgeons Oncology Group (ACOSOG) conducts cancer trials that are relevant to surgeons who treat patients with breast, thoracic, and gastrointestinal cancers. ACOSOG is funded by the National Cancer Institute and is charged with cond ... Full text Link to item Cite

Promoting patient safety.

Other Bull Am Coll Surg · December 2009 Link to item Cite

Discussion

Other American Surgeon · August 1, 2008 Cite

Improved surgeon performance in clinical trials: an analysis of quality assurance audits from the American College of Surgeons Oncology Group.

Journal Article J Am Coll Surg · September 2006 BACKGROUND: The American College of Surgeons Oncology Group (ACOSOG) represents an organized effort by surgeons to participate in clinical trials research. To assess the quality of trial conduct by surgeons on a national level and the feasibility of improv ... Full text Link to item Cite

Coin of the realm

Other Annals of Surgical Oncology · July 1, 2006 Full text Cite

Use of the National Cancer Data Base to develop clinical trials accrual targets that are appropriate for minority ethnicity patients: a report from the American College of Surgeons Oncology Group (ACOSOG) Special Population Committee.

Journal Article Cancer · January 1, 2006 BACKGROUND: Disparities in cancer outcome among different subsets of the American population related to ethnic background have been well documented. Clinical trials represent the most powerful strategy for improving cancer treatments, but racial and ethnic ... Full text Link to item Cite

Feasibility of breast duct lavage performed by a physician extender.

Journal Article Surgery · November 2004 BACKGROUND: The safety and feasibility of ductal lavage (DL), a risk-assessment tool utilizing a minimally invasive technique that permits sampling of breast duct epithelium, performed primarily by a nurse practitioner (NP), was studied prospectively. METH ... Full text Link to item Cite

Intradermal radioisotope is superior to peritumoral blue dye or radioisotope in identifying breast cancer sentinel nodes.

Journal Article J Am Coll Surg · October 2004 BACKGROUND: Sentinel lymph node (SLN) mapping and biopsy have emerged as the technique of choice for axillary staging of breast cancer. Several methods have been developed to identify SLNs, including peritumoral or intradermal injection of isosulfan blue d ... Full text Link to item Cite

A comparison of laparoscopically assisted and open colectomy for colon cancer.

Journal Article N Engl J Med · May 13, 2004 BACKGROUND: Minimally invasive, laparoscopically assisted surgery was first considered in 1990 for patients undergoing colectomy for cancer. Concern that this approach would compromise survival by failing to achieve a proper oncologic resection or adequate ... Full text Link to item Cite

The onset of genomic instability in sporadic colorectal polyps

Conference Annals of Surgical Oncology · February 2004 Full text Cite

Hereditary nonpolyposis colorectal cancer: preventive management.

Journal Article Cancer Treat Rev · December 2003 Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of hereditary colorectal cancer. Inherited mutations in the mismatch repair genes associated with this syndrome have an approximate 80% lifetime risk of colorectal cancer. Since ther ... Full text Link to item Cite

Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2.

Journal Article J Biol Chem · March 7, 2003 Angiogenesis plays a critical role in metastasis and tumor growth. Human tumors, including colorectal adenocarcinoma, secrete angiogenic factors, inducing proliferation and chemotaxis of microvascular endothelial cells, eventually leading to tumor neovascu ... Full text Link to item Cite

Rectal cancer: the sphincter-sparing approach.

Journal Article Surg Clin North Am · October 2002 There is considerable skepticism regarding sphincter-preserving surgery for rectal cancer, and 40% to 60% APR rates are reported in many prospective studies. Despite radical surgery, 20% positive margin rates are frequently reported. Rectal carcinoma respo ... Full text Link to item Cite

Radiofrequency ablation of liver tumors: influence of technique and tumor size.

Journal Article Surgery · October 2002 BACKGROUND: Radiofrequency thermal ablation (RFA) of liver tumors is done by both radiologists and surgeons by using various techniques for a variety of indications. This report describes our initial experience with RFA in 45 patients with hepatic malignan ... Full text Link to item Cite

The sentinel node in colorectal carcinoma. Mapping technique, pathologic assessment, and clinical relevance.

Journal Article Oncology (Williston Park) · May 2002 One of the most important prognostic factors in colorectal cancer is the presence or absence of regional lymph node metastases. In many instances, micrometastatic disease may not be found on routine pathologic analysis using hematoxylin and eosin staining, ... Link to item Cite

Guidelines 2000 for colon and rectal cancer surgery.

Journal Article J Natl Cancer Inst · April 18, 2001 BACKGROUND: Oncologic resection techniques affect outcome for colon cancer and rectal cancer, but standardized guidelines have not been adopted. The National Cancer Institute sponsored a panel of experts to systematically review current literature and to d ... Full text Link to item Cite

Distal margin requirements after preoperative chemoradiotherapy for distal rectal carcinomas: are < or = 1 cm distal margins sufficient?

Journal Article Ann Surg Oncol · March 2001 BACKGROUND: Sphincter-sparing alternatives to abdominoperineal resection (APR) in the treatment of rectal cancer often are underused out of concern for inadequate distal margins and local failure. The present study addresses whether sphincter-sparing techn ... Full text Link to item Cite

Lymphatic mapping and sentinel node identification for colorectal cancer.

Journal Article Swiss Surg · 2001 The primary treatment of resectable CRC is surgical resection. Postoperative adjuvant therapies are recommended when lymph node metastases are found (stage III). There is evidence that about 20% of node negative CRC cases (stage II) are understaged, i.e., ... Full text Link to item Cite

The Wexner/Hwang article reviewed

Other ONCOLOGY · December 1, 2000 Cite

Laparoscopic colectomy for cancer: an oncologic feasible option.

Journal Article Surg Oncol · November 2000 The conventional and accepted treatment for curative resection of colon cancer is laparotomy with hemicolectomy for right or left sided lesions. The technique of colon resection through an open laparotomy incision is well known. Over the past several years ... Full text Link to item Cite

Treatment of primary colon cancer with peritoneal carcinomatosis: comparison of concomitant vs. delayed management.

Other Dis Colon Rectum · October 2000 PURPOSE: The initial dissemination of colon cancer occurs through three routes: the lymphatics, the portal blood, and the peritoneal surfaces. Although lymphatic and hematogenous metastases indicate an aggressive disease process, it is possible that dissem ... Full text Link to item Cite

Enhanced staging and all chemotherapy preoperatively in patients with potentially resectable gastric carcinoma.

Journal Article J Clin Oncol · August 1999 PURPOSE: Patients with local-regional gastric carcinoma have a low rate of curative resection (R0) because of the advanced stage at diagnosis and suboptimal clinical staging. This study was designed to improve clinical staging with the use of laparoscopy a ... Full text Link to item Cite

Peritoneal and serum tumor markers predict recurrence and survival of patients with resectable gastric cancer.

Journal Article Gastric Cancer · May 1999 BACKGROUND: Laparoscopy has become a useful adjunct for the staging of gastric cancer; yet, other than standard TNM staging, few additional variables can be used to predict survival. This study evaluated the utility of serum and peritoneal tumor markers (c ... Full text Link to item Cite

Clinical, pathologic, and economic parameters of laparoscopic colon resection for cancer.

Journal Article Am J Surg · December 1998 BACKGROUND: The appropriateness of laparoscopic colon resection (LCR) as treatment for malignancy has been questioned. METHODS: From 1992 to 1997, 91 patients were entered into a prospective study of LCR for cancer. Clinical, pathologic, and economic param ... Full text Link to item Cite

Surgical management of aberrant sentinel lymph node drainage in cutaneous melanoma.

Journal Article Surgery · October 1998 BACKGROUND: Sentinel lymph node (SLN) mapping by lymphoscintigraphy has changed the surgical management of regional lymph node metastases for melanoma. SLNs lying outside of traditional nodal basins are now being identified. Our hypothesis is that when pre ... Full text Link to item Cite

Colon cancer.

Journal Article Cancer Treat Res · 1997 Full text Link to item Cite

Laparoscopic colon resection for cancer.

Journal Article Surg Endosc · December 1995 Link to item Cite

Preoperative infusional chemoradiation therapy for stage T3 rectal cancer.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 1995 PURPOSE: To evaluate preoperative infusional chemoradiation for patients with operable rectal cancer. METHODS AND MATERIALS: Preoperative chemoradiation therapy using infusional 5-fluorouracil (5-FU), (300 mg/m2/day) together with daily irradiation (45 Gy/ ... Full text Link to item Cite

Preoperative infusional chemoradiation and surgery with or without an electron beam intraoperative boost for advanced primary rectal cancer.

Journal Article Int J Radiat Oncol Biol Phys · April 30, 1995 PURPOSE: To compare the multimodality treatment results of surgical resection plus preoperative radiotherapy with concomitant protracted infusion chemotherapy (preop-chemoXRT), with or without an electron beam intraoperative radiotherapy (EB-IORT) boost, i ... Full text Link to item Cite

Virtual reality in surgical education.

Journal Article Comput Biol Med · March 1995 Virtual reality (VR) is an emerging technology that can teach surgeons new procedures and can determine their level of competence before they operate on patients. Also VR allows the trainee to return to the same procedure or task several times later as a r ... Full text Link to item Cite

Value of serial carcinoembryonic antigen levels in patients with resectable adenocarcinoma of the esophagus and stomach.

Journal Article Cancer · January 15, 1995 BACKGROUND: Adenocarcinomas of the esophagus and the stomach are highly virulent and remain a major health problem worldwide; 5-year survival rates have not changed in the past 30 years. Recently, preoperative chemotherapy has been used to treat these aden ... Full text Link to item Cite

Potentially resectable gastric carcinoma: current approaches to staging and preoperative therapy.

Journal Article World J Surg · 1995 The incidence of gastric carcinoma has declined worldwide during the past several decades, and yet this cancer remains the most common malignancy in several countries around the world, particularly Japan, Chile, and Costa Rica. Gastric carcinoma, although ... Full text Link to item Cite

Complications and failures of subclavian-vein catheterization.

Journal Article N Engl J Med · December 29, 1994 BACKGROUND: Although catheterization of the subclavian vein is a common procedure, the risk factors for complications and failures, with the exception of the physician's experience, are poorly understood. Ultrasonography has been recommended to help guide ... Full text Link to item Cite

Pharmacologic intervention can reestablish baseline hemodynamic parameters during laparoscopy.

Journal Article Surgery · October 1994 BACKGROUND: Several studies in both animal models and human beings have shown that CO2 abdominal insufflation for laparoscopy can cause a variety of alterations in hemodynamic and pulmonary physiology. These physiologic changes could potentially have delet ... Link to item Cite

Laparoscopic-assisted segmental colectomy: surgical techniques.

Journal Article Mayo Clin Proc · September 1994 OBJECTIVE: To describe our surgical techniques for successful completion of laparoscopic-assisted segmental colectomy. DESIGN: We reviewed the important preoperative, operative, and postoperative factors that should be considered for laparoscopic resection ... Full text Link to item Cite

Laparoscopic intracorporeal harvest of jejunal tissue for autologous transplantation.

Journal Article Surg Laparosc Endosc · June 1994 Our goal in this study was to assess the feasibility and safety of performing an intracorporeal laparoscopic jejunal harvest. The initial technique was developed and refined in a pig and then a dog model. In the animal studies, careful dissection of the je ... Link to item Cite

Laparoscopic intestinal stomas.

Journal Article Dis Colon Rectum · May 1994 PURPOSE: We report our early experiences with laparoscopic intestinal stomas, describing the indications, the surgical techniques, and the complications of this new procedure. METHODS: The medical records of the 17 patients who had successfully undergone l ... Full text Link to item Cite

Patterns of residual disease after preoperative chemoradiation in ultrasound T3 rectal carcinoma.

Journal Article Ann Surg Oncol · March 1994 BACKGROUND: Rectal carcinoma tends to recur locally, with invasion of adjacent organs and significant pelvic pain. Both radiation therapy alone and combined chemoradiation have been used in an attempt to decrease the local recurrence rate and thereby impro ... Full text Link to item Cite

Late complications of postoperative radiation therapy for cancer of the rectum and rectosigmoid.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 1994 PURPOSE: We retrospectively examined the surgical, medical, radiotherapeutic and technical factors associated with late small bowel and nonsmall bowel morbidity. METHODS AND MATERIALS: The medical records of 224 patients with cancer of the rectum and recto ... Full text Link to item Cite

MUC1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma.

Journal Article Gastroenterology · February 1994 BACKGROUND/AIMS: The MUC1 mucin distributes among a variety of epithelial tissues (except the intestinal epithelia) and is often detectable in colorectal carcinoma tissues and cell lines. This study aimed to elucidate whether MUC1 mucin expression correlat ... Full text Link to item Cite

Laparoscopic Management of Colon Cancer

Journal Article Surgical Innovation · January 1, 1994 Laparoscopic procedures for colon neoplasms have the potential to reduce hospital recovery time and costs and to increase patient quality of life postoperatively. Laparoscopic colectomy for potentially curable colon carcinoma is in its developmental phase. ... Full text Cite

Controversies regarding laparoscopic colectomy for malignant diseases.

Journal Article Curr Opin Gen Surg · 1994 Surgical investigators have shown that a hemicolectomy can be done laparoscopically. This minimally invasive approach to treat colon cancer potentially reduces hospitalization time, hastens return to normal activity, and reduces health care costs. Hopefull ... Link to item Cite

Carbohydrate-mediated cell adhesion as a determinant of colorectal cancer metastasis

Journal Article Cancer Bulletin · January 1, 1994 HUMAN COLORECTAL carcinomas with increased metastatic potential and poor prognosis are characterized by the high content of sialyl-Lewis X carbohydrate antigen (Neu5Acα2-3Galβ1-4 [Fucα1-3]GlcNAc-R). The levels of these carbohydrate antigens apparently incr ... Cite

Preoperative and postoperative combination chemotherapy for potentially resectable gastric carcinoma.

Journal Article J Natl Cancer Inst · November 17, 1993 BACKGROUND: Median survival of patients with local-regional gastric carcinoma is 10 months. Resection of the primary tumor and regional lymph nodes, with tumor-free margins (curative resection), has been the most effective treatment for local-regional gast ... Full text Link to item Cite

Colorectal cancer metastasis determined by carbohydrate-mediated cell adhesion: role of sialyl-LeX antigens.

Journal Article Semin Cancer Biol · October 1993 Human colorectal carcinomas with increased metastatic potential and with poor prognosis are characterized by the high content of sialyl-LeX carbohydrate antigens. The levels of these carbohydrate antigens apparently increase during colorectal carcinoma pro ... Link to item Cite

Chemoradiation therapy for anal cancer: radiation plus continuous infusion of 5-fluorouracil with or without cisplatin.

Journal Article Radiother Oncol · June 1993 Chemoradiation therapy for anal cancer was carried out in 58 patients using low-dose, continuous infusion of 5-fluorouracil (5-FU) with or without continuous infusion of cisplatin (cDDP) and external beam irradiation (chemoXRT). Thirty-nine patients receiv ... Full text Link to item Cite

Preoperative chemotherapy and radiation therapy for locally advanced primary and recurrent rectal carcinoma. A report of surgical morbidity.

Journal Article Cancer · June 1, 1993 BACKGROUND: Complete surgical resection of locally advanced primary and recurrent rectal cancer is often incomplete. Improved tumor downstaging may improve resection rates and local control if postoperative morbidity is not increased. METHODS: The clinical ... Full text Link to item Cite

Glutamine stability in biological tissues evaluated by fluorometric analysis.

Journal Article Clin Chem · June 1993 Although glutamine has been considered unstable during storage and therefore difficult to quantitate, recent results suggest this amino acid is stable at low pH ranges. We evaluated the stability of glutamine in plasma and tissue extracts, using fluorometr ... Link to item Cite

Pathologic, anatomic, and biologic factors correlated with local recurrence of colorectal cancer

Journal Article Seminars in Radiation Oncology · January 1, 1993 The anatomic patterns of failure after surgical resection of colorectal cancer have been well described and have provided useful clinical information for selecting patients who are at high risk for local-regional failure. Based on these studies, adjuvant p ... Full text Cite

Substituting ornithine for arginine in total parenteral nutrition eliminates enhanced tumor growth.

Journal Article J Surg Oncol · July 1992 Total parenteral nutrition (TPN) may enhance the growth of some tumors: this enhanced growth is associated with an increase in the erythrocyte polyamine levels. The effect of arginine in TPN on tumor growth was compared with ornithine using rats with a tra ... Full text Link to item Cite

Laparoscopic feeding jejunostomy tube in oncology patients.

Journal Article Surg Oncol · June 1992 Laparoscopic-guided feeding jejunostomy tubes are being utilized in two specific groups of patients: (i) patients with resectable or locally advanced adenocarcinoma of the pancreas treated on a protocol of preoperative chemoradiation, who may require nutri ... Full text Link to item Cite

13-cis-retinoic acid and interferon alpha-2a: effective combination therapy for advanced squamous cell carcinoma of the skin.

Journal Article J Natl Cancer Inst · February 19, 1992 BACKGROUND: Retinoids (vitamin A derivatives) and interferon-alpha (IFN-alpha) are potent regulators of malignant cell differentiation and proliferation, and both have immunomodulatory and antiangiogenesis activity. A large body of preclinical and clinical ... Full text Link to item Cite

Nutritional support of the critically ill cancer patient

Journal Article Cancer Bulletin · January 1, 1992 Cite

Operative and adjuvant treatment strategies for gastric carcinoma

Journal Article Cancer Bulletin · January 1, 1992 Cite

Complications associated with indwelling catheters.

Journal Article Med Pediatr Oncol · 1992 Between 1983 and 1985, 170 consecutive patients received doxorubicin-containing adjuvant chemotherapy through central venous catheters, and four via a long indwelling catheter in the antecubital fossa. The objective of this retrospective study is to determ ... Full text Link to item Cite

Amelioration of thrombocytopenia with concomitant ornithine in sarcoma-bearing rats receiving high dose difluoromethylornithine.

Journal Article Invest New Drugs · November 1991 The dose limiting toxicity of difluoromethylornithine (DFMO), when administered by continuous infusion, is thrombocytopenia. DFMO-induced antitumor activity and thrombocytopenia were time- and dose-dependent up to 1700 mg/kg/d when administered continuousl ... Full text Link to item Cite

A case-control comparison of durability and cost between implanted reservoir and percutaneous catheters in cancer patients.

Journal Article J Surg Res · November 1991 A case-control study was performed to compare the durability and cost of implanted reservoir catheter systems with percutaneous central venous catheters. Twenty cancer patients had reservoir systems placed in 1985 for chemotherapy delivery. The control gro ... Full text Link to item Cite

Human colonic sulfomucin identified by a specific monoclonal antibody.

Journal Article Cancer Res · October 15, 1991 Since the 1960s, the loss of sulfomucin from colonic epithelium has been considered to be an indicator of an early stage of carcinogenesis; yet, the biochemical basis for this phenomenon has never been elucidated. We recently prepared a monoclonal antibody ... Link to item Cite

Resectable gastric carcinoma. An evaluation of preoperative and postoperative chemotherapy.

Journal Article Cancer · October 1, 1991 Patients with locoregional gastric carcinoma often die because of the low rates of curative resection and frequent appearance of distant metastases (mainly peritoneal and hepatic). To evaluate the feasibility of preoperative and postoperative chemotherapy, ... Full text Link to item Cite

Histologic observations and P-glycoprotein expression in gastric and esophageal adenocarcinomas treated with preoperative chemotherapy.

Journal Article Arch Pathol Lab Med · August 1991 To describe histologic changes associated with chemotherapy response, we reviewed biopsy and resection specimens from 52 patients with locally advanced esophageal or gastric adenocarcinoma who were treated with preoperative chemotherapy, followed by resect ... Link to item Cite

Lactose-binding lectin expression in human colorectal carcinomas. Relation to tumor progression.

Journal Article Carbohydr Res · June 25, 1991 Lactose-binding lectins having Mr values of approximately 14,000 (L-14.5) and approximately 35,000 Da have been found in a variety of vertebrate tissues, including normal intestine and colon, and in several types of tumors such as colon carcinomas. To dete ... Full text Link to item Cite

Colorectal ornithine decarboxylase activity in human mucosa and tumors: elevation of enzymatic activity in distal mucosa.

Journal Article J Surg Oncol · June 1991 To examine the value of ornithine decarboxylase (ODC) assay as a biological marker of potential malignancy in large bowel, we harvested 43 colorectal carcinoma, 7 adenoma, 6 polyps, and 77 normal-appearing mucosa at surgery from patients with colorectal ca ... Full text Link to item Cite

Ectopic expression of mucins in colorectal cancer metastasis.

Journal Article Semin Cancer Biol · April 1991 Cancer metastasis is an ectopic growth of malignant cells. In human colorectal cancer, it is hypothesized that, during the progression of the disease to an advanced stage, highly malignant and metastatic tumor cells arise within primary tumors and become p ... Link to item Cite

Increased content of an endogenous lactose-binding lectin in human colorectal carcinoma progressed to metastatic stages.

Journal Article Cancer Res · January 1, 1991 The quantity and localization of two lactose-binding lectins with molecular weights of 31,000 and 14,500 in human colorectal carcinoma tissue specimens obtained by surgical resection have been studied using specific polyclonal antibodies. Electrophoretic s ... Link to item Cite

Metastatic behavior and cell surface properties of HT-29 human colon carcinoma variant cells selected for their differential expression of sialyl-dimeric Le(x)-antigen.

Journal Article Clin Exp Metastasis · 1991 Immunochemical studies of human colorectal carcinoma with various monoclonal antibodies against Le(X)-related carbohydrate antigens previously revealed that the amount of sialyl-dimeric Le(X) antigen (NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1 ... Full text Link to item Cite

Sialyl-dimeric Lewis-X antigen expressed on mucin-like glycoproteins in colorectal cancer metastases.

Journal Article Lab Invest · December 1990 Colorectal primary carcinomas and metastases from 20 Dukes' stage C or D patients were examined for the immunohistochemical localization and contents of various fucosylated N-acetyl-lactosamine oligomers by specific monoclonal antibodies (MAbs). MAbs used ... Link to item Cite

Outpatient percutaneous central venous access in cancer patients.

Journal Article Am J Surg · December 1990 A 1-year experience of percutaneous subclavian catheterization in outpatients with cancer was reviewed to document reliability, safety, and cost. There were 763 catheter insertions attempted with prospective documentation of complications in 664 consecutiv ... Full text Link to item Cite

Soluble factor in normal tissues that stimulates high-molecular-weight sialoglycoprotein production by human colon carcinoma cells.

Journal Article Cancer Res · June 1, 1990 The stimulation of high molecular weight sialoglycoprotein synthesis by a soluble factor derived from normal colon tissues was studied in vitro with human colon carcinoma cell lines, HT-29 P and a metastatic variant HT-29 LMM. The synthesis of all three hi ... Link to item Cite

Metastatic potential of colon carcinoma. Expression of ABO/Lewis-related antigens.

Journal Article Arch Surg · February 1990 Four monoclonal antibodies specific to various Lewisx-related antigens were tested for binding to monolayers and detergent extracts of the human colon carcinoma cell line HT-29 P and its metastatic variant HT-29 LMM. Only monoclonal antibody FH6 (antisialy ... Full text Link to item Cite

Evaluation of continuous-infusion alpha-difluoromethylornithine therapy for colorectal carcinoma.

Journal Article Cancer Chemother Pharmacol · 1990 A total of 32 evaluable patients with measurable advanced colorectal carcinoma were treated with continuous-infusion alpha-difluoromethylornithine (DFMO) at a median daily dose of 8 g/m2 (range, 6-14 g/m2). DFMO was infused over 24 h daily for 28 days, fol ... Full text Link to item Cite

Increased expression of sialyl-dimeric LeX antigen in liver metastases of human colorectal carcinoma.

Journal Article Cancer Res · December 15, 1989 We collected a total of 78 tissue specimens, including primary colorectal carcinoma, normal colonic mucosa, and liver metastases of colon carcinoma, to examine whether the extracts of these tissues inhibited the binding of a monoclonal antibody FH6, specif ... Link to item Cite

Alterations in polyamine metabolism during continuous intravenous infusion of alpha-difluoromethylornithine showing correlation of thrombocytopenia with alpha-difluoromethylornithine plasma levels.

Journal Article Cancer Res · October 15, 1989 Polyamine biosynthesis is important for cell proliferation and growth. The purpose of this study was to determine the biochemical and pharmacological parameters associated with host toxicity from a continuous infusion of alpha-difluoromethylornithine (DFMO ... Link to item Cite

Transpelvic rectus abdominis flap reconstruction of defects following abdominal-perineal resection.

Journal Article Am Surg · October 1989 Abdominal-perineal resection for advanced rectal carcinoma may leave a large defect for which complete secondary healing can be slow. In such cases, the inferiorly based rectus abdominis myocutaneous flap, passed through the pelvis into the perineum, can p ... Link to item Cite

Reduction of difluoromethylornithine-induced thrombocytopenia in rats with ornithine while maintaining antitumor activity.

Journal Article Cancer Res · August 1, 1989 The purpose of this study was to evaluate the effect of a concomitant infusion of ornithine on the difluoromethylornithine (DFMO)-induced thrombocytopenia and antitumor activity. Male Fischer 344 rats with either a transplantable fibrosarcoma or Ward colon ... Link to item Cite

Monoclonal antibody against human colonic sulfomucin: immunochemical detection of its binding sites in colonic mucosa, colorectal primary carcinoma, and metastases.

Journal Article Cancer Res · February 15, 1989 Previous studies using metabolic labeling of fresh colonic mucosa and colorectal carcinoma with [35S]sulfate followed by biochemical analysis demonstrated that the amount of a sulfated high-molecular-weight glycoprotein expressed in primary colorectal carc ... Link to item Cite

Prospective phase I trial of conservative management of low rectal lesions.

Journal Article Arch Surg · January 1989 The purpose of this study was to assess and function and to compare the morbidity of local excision and postoperative radiotherapy for rectal adenocarcinoma with the morbidity of abdominoperineal resection. A posterior parasacral approach was used for loca ... Full text Link to item Cite

Differential effects of parenteral nutrition on tumor growth and erythrocyte polyamine levels in the rat.

Journal Article JPEN J Parenter Enteral Nutr · 1989 The influence of total parenteral nutrition (TPN) on tumor growth and erythrocyte polyamine levels was evaluated in rats with a transplantable fibrosarcoma or a Ward colon tumor. During the experimental periods the fibrosarcoma grows exponentially when rat ... Full text Link to item Cite

Polyamine-directed preferential nutritional repletion of normal tissues in tumor-bearing hosts.

Journal Article Int J Cancer · November 15, 1988 Our previous study demonstrated that total parenteral nutrition (TPN) increases erythrocyte (RBC) polyamines selectively in cancer patients but not in non-cancer patients, suggesting that these changes may relate to tumor presence. We therefore studied the ... Full text Link to item Cite

Differential expression of a sialoglycoprotein with an approximate molecular weight of 900,000 on metastatic human colon carcinoma cells growing in culture and in tumor tissues.

Journal Article Cancer Res · May 1, 1988 Wheat germ agglutinin (WGA)-binding cellular glycoproteins produced by HT-29 human colon carcinoma and its variant cells established from liver metastases in nude mice after intrasplenic injection were analyzed by polyacrylamide gel electrophoresis. On 5.5 ... Link to item Cite

Electrophoretic analysis of four high molecular weight sialoglycoproteins produced by metastatic human colon carcinoma cells.

Journal Article J Cell Biochem · May 1988 We have found that polyacrylamide gel electrophoresis in 3% gels in the presence of sodium dodecyl sulfate is suitable for the separation of cellular glycoproteins having molecular weights ranging from 200,000 to 1,000,000. The gels secured on a rigid supp ... Full text Link to item Cite

Increased content of chondroitin sulfate proteoglycan in human colorectal carcinoma metastases compared with the primary tumor as determined by an anti-chondroitin-sulfate monoclonal antibody.

Journal Article J Cell Biochem · April 1988 To determine if the amount of chondroitin sulfate proteoglycan (CSPG) in human colorectal tumor tissue correlates with the tumor's aggressiveness we immunochemically determined the CSPG levels in colorectal carcinomas at different stages. A total of 50 spe ... Full text Link to item Cite

MODULATION OF DIFLUOROMETHYLORNITHINE TOXICITY BY CONCOMITANT ORNITHINE TREATMENT IN TUMOR-BEARING RATS

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1988 Link to item Cite

Glycoconjugates and tumor metastasis.

Journal Article Adv Exp Med Biol · 1988 Full text Link to item Cite

Influence of total parenteral nutrition on tumor growth and polyamine biosynthesis of fibrosarcoma-bearing rats after induced cachexia.

Journal Article JPEN J Parenter Enteral Nutr · 1988 The effect of a protein-free diet (PF) or a restricted intake of chow (RI) and subsequent host repletion with total parenteral nutrition (PF-TPN, RI-TPN) on tumor growth and polyamine metabolism of fibrosarcoma-bearing rats was examined. Host weight was si ... Full text Link to item Cite

HUMAN COLONIC SULFOMUCIN AND AN ANTI-SULFOMUCIN MONOCLONAL-ANTIBODY

Conference GLYCOCONJUGATE JOURNAL · January 1, 1988 Link to item Cite

Bioavailability of estradiol as a marker for breast cancer risk assessment.

Journal Article Cancer Res · October 1, 1987 The search for a hormonal marker in breast cancer has centered on estrogens and their metabolites. However, direct measurements of total amounts of these steroids have shown no convincing or consistent differences between normal women and women with breast ... Link to item Cite

Polyamine metabolism in carcinoma of the oral cavity compared with adjacent and normal oral mucosa.

Journal Article Am J Surg · October 1987 In this study, polyamine biosynthesis required for cellular proliferation showed elevated levels in neoplastic cells. Putrescine, spermidine, and spermine, as well as the rate-limiting enzyme ornithine decarboxylase, were measured to evaluate differences i ... Full text Link to item Cite

The relationship of collagenolytic activity to stage of human colorectal carcinoma.

Journal Article Int J Cancer · July 15, 1987 Collagenolytic enzymes produced by tumor cells are believed to play a significant role in the destruction of surrounding normal tissue and, in certain experimental animal systems, the ability of tumor cells to degrade type-IV collagen (basement membrane co ... Full text Link to item Cite

Differential production of high molecular weight sulfated glycoproteins in normal colonic mucosa, primary colon carcinoma, and metastases.

Journal Article Cancer Res · May 15, 1987 Sulfated macromolecules synthesized in tumor and mucosa tissues derived from colorectal cancer patients were labeled with [35S]sulfate and separated into two fractions on DEAE-Sephacel: the slightly acidic peak (peak I) was eluted with 0.2 M NaCl and the h ... Link to item Cite

Effect of intravenous alpha-difluoromethylornithine on the polyamine levels of normal tissue and a transplantable fibrosarcoma.

Journal Article Cancer Res · April 1, 1987 The effect of a continuous i.v. infusion of alpha-difluoromethylornithine (DFMO) on the polyamine metabolism of tumor and normal host tissue was determined. Non-tumor-bearing Fischer 344 rats or rats bearing a transplantable fibrosarcoma received continuou ... Link to item Cite

DIFFERENTIAL EFFECT OF DIFLUOROMETHYLORNITHINE (DFMO) ON HEPATIC AND TUMOR POLYAMINE METABOLISM IN SARCOMA-BEARING RATS

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1987 Link to item Cite

POLYAMINE DIRECTED PREFERENTIAL NUTRITIONAL REPLETION OF NORMAL-TISSUES IN TUMOR-BEARING HOSTS

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1987 Link to item Cite

ADHESIVE PROPERTIES OF HUMAN-COLON CARCINOMA-CELLS ESTABLISHED FROM PRIMARY TUMOR AND METASTASES

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1987 Link to item Cite

Ulex europeus agglutinin I-reactive high molecular weight glycoproteins of adenocarcinoma of distal colon and rectum and their possible relationship with metastatic potential.

Journal Article Cancer Res · February 1, 1987 A Ulex europeus agglutinin I (UEAI)-reactive glycoprotein(s) with molecular weight higher than 300,000 was detected by direct binding of 125I-labeled UEAI to lysates of rectal or sigmoid colon cancer tissues separated by polyacrylamide gel electrophoresis ... Link to item Cite

Bioavailability of Estradiol as a Marker for Breast Cancer Risk Assessment

Journal Article Cancer Research · January 1, 1987 The search for a hormonal marker in breast cancer has centered on estrogens and their metabolites. However, direct measurements of total amounts of these steroids have shown no convincing or consistent differences between normal women and women with breast ... Cite

Red blood cell polyamine levels and host toxicity during continuous alpha-difluoromethylornithine infusion.

Journal Article Int J Cancer · August 15, 1986 The dose effects of continuous alpha-difluoromethylornithine (DFMO) infusion on red blood cell (RBC) polyamine levels, host toxicity and tumor growth were determined. Male rats with and without a transplantable methylcholanthrene-induced sarcoma received i ... Full text Link to item Cite

Relationship of erythrocyte polyamine levels and growth rate of transplantable tumors in rats.

Journal Article Cancer Res · July 1986 Varying levels of polyamines in the urine, plasma, and erythrocytes (RBC) of cancer patients have been demonstrated. The growth rate of the tumor has been suggested as a primary factor which determines whether the polyamine levels in urine are elevated. To ... Link to item Cite

Erythrocyte polyamine levels during intravenous feeding of patients with colorectal carcinoma.

Journal Article Eur J Cancer Clin Oncol · July 1986 Changes in erythrocyte (RBC) polyamines were studied during total parenteral nutrition (TPN) in 16 colorectal carcinoma patients and six patients with noncancerous diseases. RBC putrescine (PTC), spermidine (SPD), and spermine (SPM) were analyzed before an ... Full text Link to item Cite

ANTITUMOR-ACTIVITY AND HOST TOXICITY OF CONTINUOUS INTRAVENOUS (IV) ALPHA-DIFLUOROMETHYLORNITHINE (DFMO)

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1986 Link to item Cite

COLLAGENOLYTIC ACTIVITIES OF HUMAN COLORECTAL-CARCINOMA AT DIFFERENT STAGES

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1986 Link to item Cite

SULFATED GLYCOCONJUGATES PRODUCED BY HUMAN-COLON CARCINOMA CELL-LINES WITH DIFFERENT METASTATIC POTENTIALS

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1986 Link to item Cite

Obesity, non-protein-bound estradiol levels, and distribution of estradiol in the sera of breast cancer patients.

Journal Article Cancer · February 1, 1986 This study attempted to determine the relationship of nutritional status, menopausal status, presence of breast cancer, stage of disease, and tumor estrogen receptor levels to percent non-protein-bound estradiol (%NPBE) and percent distribution of estradio ... Full text Link to item Cite

Ornithine decarboxylase activity of normal tissue from tumor-bearing rats

Journal Article Journal of Nutrition Growth and Cancer · January 1, 1986 Cite

Active specific immunotherapy of Dukes B2 and C colorectal carcinoma: comparison of two doses of the vaccine.

Journal Article Cancer Immunol Immunother · 1986 The ability of active specific immunotherapy to enhance immune responses to autologous tumor-associated antigens (TAA) and to prolong the disease-free interval was evaluated in patients with Dukes B2 and C colorectal carcinoma who had undergone potentially ... Full text Link to item Cite

Plasma proteins as indices of response to nutritional therapy in cancer patients.

Journal Article J Surg Oncol · July 1985 The use of plasma albumin (ALB), transferrin (TFN), prealbumin (TBPA), retinol-binding protein (RBP), triceps skin fold (TSF), and midarm muscle circumference (MAMC) as determinants of response to nutritional therapy (TPN) was investigated in 40 cancer pat ... Full text Link to item Cite

Effect of difluoromethylornithine on host and tumor polyamine metabolism during total parenteral nutrition.

Journal Article J Surg Res · June 1985 Clinical and experimental data suggest that erythrocyte (RBC) polyamine (PA) levels are markers of tumor proliferation during total parenteral nutrition (TPN). The purpose of this experiment was to determine whether the inhibition of PA synthesis during TP ... Full text Link to item Cite

Growth kinetics of human colorectal carcinoma.

Journal Article Cancer Res · May 1985 In this study, we investigated the influence of some of the variables of the thymidine labeling index (TLI) in human colorectal carcinoma. These variables were: cell suspensions versus tissue fragments; incubation with 5-fluoro-2'-deoxyuridine; method of t ... Link to item Cite

Monitoring difluoromethyl ornithine(DFMO) inhibition of tumor polyamine(PA) synthesis

Conference Proceedings of the American Association for Cancer Research · January 1, 1985 Cite

A surgical oncology perspective on AIDS.

Journal Article Semin Surg Oncol · 1985 During the summer of 1981 reports of unusual opportunistic infections among male homosexuals first began to appear in the literature and by December 1983, 3000 cases has been reported to the Center for Disease Control in Atlanta, Georgia. Homosexual and bi ... Full text Link to item Cite

Perioperative blood transfusion in patients with colon carcinoma.

Journal Article Transfusion · 1985 The effect of perioperative blood transfusion on 5- and 10-year survival following curative resection for intra-abdominal colon carcinoma was investigated retrospectively. Two hundred and seven patients with Dukes' stages A, B, and C carcinoma were divided ... Full text Link to item Cite

Glycoprotein analysis of human rectum and Sigmoid colon carcinomas at various stages of metastases using lectins

Conference Proceedings of the American Association for Cancer Research · January 1, 1985 Cite

Absence of a relationship of size of primary colon carcinoma with metastasis and survival.

Journal Article Clin Exp Metastasis · 1985 This retrospective study analysed the relationship of tumor size to regional and systemic metastasis and to survival according to stage of disease. Colon cancers (391 cases) that were treated surgically at M. D. Anderson Hospital from 1955 to 1975 were rev ... Full text Link to item Cite

Immune function during intravenous administration of a soybean oil emulsion.

Journal Article JPEN J Parenter Enteral Nutr · 1985 The effect of a continuous infusion of a soybean oil emulsion on immune function was evaluated in 40 malnourished patients who were randomized to receive preoperatively either a 25% glucose-5% amino acid solution (group G) or a 15% glucose-3.3% Intralipid- ... Full text Link to item Cite

GLYCOPROTEIN ANALYSIS OF HUMAN RECTUM AND SIGMOID COLON CARCINOMAS AT VARIOUS STAGES OF METASTASES USING LECTINS

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1985 Link to item Cite

Nutritional parameters affecting erythrocyte polyamine levels in cancer patients.

Journal Article J Clin Oncol · October 1984 Changes in erythrocyte polyamine levels during intravenous hyperalimentation in cancer and noncancer patients were determined, and the influence of host nutritional status on polyamine metabolism was analyzed. RBC putrescine (P less than .001), spermidine ... Full text Link to item Cite

IMMUNE FUNCTION DURING SOYBEAN OIL EMULSION INFUSION

Conference JOURNAL OF PARENTERAL AND ENTERAL NUTRITION · January 1, 1984 Link to item Cite

NUTRITIONAL-STATUS AND ERYTHROCYTE (RBC) POLYAMINES (PA) LEVELS IN FIBRO-SARCOMA BEARING RATS

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1984 Link to item Cite

Hyperalimentation and oncologic management: update.

Journal Article Compr Ther · November 1983 Link to item Cite

Effect of serum source on protein-free diet lymphocyte blastogenesis.

Journal Article J Surg Res · September 1983 The influence of protein depletion on serum factors in PHA lymphocyte blastogenesis was studied in a rat model. Buffalo rats were divided randomly into two groups and fed either a protein-free (PF) diet or a regular 25% protein diet (RD). At weekly interva ... Full text Link to item Cite

Modification of polycarbonate cages for individual housing of mice.

Journal Article Lab Anim Sci · August 1983 Polycarbonate cages were modified with clear plastic dividers so that up to four mice could be housed individually in one cage with ad libitum access to feed and water. The method used commercially available components and was applicable for use in any stu ... Link to item Cite

NUTRITIONAL-STATUS AND ANTI-TUMOR ACTIVITY OF CYCLOPHOSPHAMIDE (CP) AGAINST L1210 LEUKEMIA

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1983 Link to item Cite

GASTROINTESTINAL CANCER .5. NUTRITIONAL THERAPY IN CANCER-PATIENTS

Journal Article PRACTICAL GASTROENTEROLOGY · January 1, 1982 Link to item Cite

A clinical review of nutritional support of the patient.

Journal Article JPEN J Parenter Enteral Nutr · 1979 Full text Link to item Cite

The effects of nutrition and treatment of cancer on host immunocompetence.

Journal Article Surg Gynecol Obstet · January 1979 Conventional approaches to therapy for cancer, such as chemotherapy, operative therapy and radiation therapy, can produce profound changes in host immunity. The effects of chemotherapy upon immune responses are related both to the dosage and duration of th ... Link to item Cite

The effects of a 10% soybean oil emulsion on lymphocyte transformation.

Journal Article JPEN J Parenter Enteral Nutr · May 1978 Free essential fatty acids (EFA) are reported to suppress cell-mediated immunity. Because Intralipid contains a high concentration of esterified EFA, the effects of this emulsion on in vitro lymphocyte transformation were studied. Intralipid concentrations ... Full text Link to item Cite

Total parenteral nutrition.

Journal Article Surgery · May 1978 Link to item Cite

Effects of intralipid on lymphocyte transformation

Conference Federation Proceedings · January 1, 1977 Cite

EFFECTS OF INTRALIPID ON LYMPHOCYTE-TRANSFORMATION

Conference FEDERATION PROCEEDINGS · 1977 Cite