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James Patrick Daubert

James Patrick Daubert

Professor of Medicine
Medicine, Cardiology
james.daubert@duke.edu
Duke Box 3174, Duke University Medical Center, Durham, NC 27710
Room 8678B, HAFS (Hospital Annex for Surgery), Durham, NC 27710

Selected Publications

Rationale and design of the comparative effectiveness of ICD vs non-ICD therapy in contemporary heart failure patients at a low risk for arrhythmic death (CONTEMP-ICD) trial.

Journal Article Am Heart J · January 2026 BACKGROUND: Current recommendations for a prophylactic (primary prevention) implantable cardioverter defibrillator (ICD) in patients with both ischemic and nonischemic heart failure with reduced ejection fraction (HFrEF) originate from clinical trials cond ... Full text Link to item Cite

Reassessing the need for primary prevention implantable cardioverter-defibrillators in contemporary patients with heart failure.

Journal Article J Card Fail · August 2025 The main function of the implantable cardioverter-defibrillator (ICD) is to protect against sudden cardiac death (SCD) due to ventricular tachyarrhythmia (VTA). Current guidelines provide a recommendation to implant a prophylactic ICD for the primary preve ... Full text Link to item Cite

Use of a Stylet Driven Lead With a Flexible Neck for Left Bundle Branch Area Pacing: A Single Center Experience.

Journal Article J Cardiovasc Electrophysiol · April 2025 BACKGROUND: The majority of data on left bundle branch area pacing (LBBAP) are on a lumenless lead. Data on the safety and effectiveness of stylet driven leads are comparatively lacking. METHODS: We retrospectively analyzed 265 patients who underwent attem ... Full text Link to item Cite

Reassessing the need for primary prevention implantable cardioverter-defibrillators in contemporary patients with heart failure.

Journal Article Heart rhythm · April 2025 The main function of the implantable cardioverter-defibrillator (ICD) is to protect against sudden cardiac death (SCD) due to ventricular tachyarrhythmia (VTA). Current guidelines provide a recommendation to implant a prophylactic ICD for the primary preve ... Full text Cite

Appropriate and inappropriate ICD shocks in patients with LVADs: Prevalence, associated factors, and etiologies.

Journal Article Heart Rhythm · February 2025 BACKGROUND: Implantable cardioverter-defibrillator (ICD) shocks are a common complication after left ventricular assist device (LVAD) implantation; however, data on their frequency and causes are limited. OBJECTIVE: The purpose of this study was to define ... Full text Link to item Cite

Assessment of Antitachycardia Pacing in Primary Prevention Patients: The APPRAISE ATP Randomized Clinical Trial.

Journal Article JAMA · November 26, 2024 IMPORTANCE: The emergence of novel programming guidelines that reduce premature and inappropriate therapies along with the availability of new implantable cardioverter-defibrillator (ICD) technologies lacking traditional endocardial antitachycardia pacing ... Full text Link to item Cite

Randomized Trial of Patiromer on Efficacy to Reduce Episodic Hyperkalemia in Patients with ESKD Treated With Hemodialysis.

Journal Article Kidney Int Rep · November 2024 INTRODUCTION: Individuals with end-stage kidney disease (ESKD) maintained on hemodialysis (HD) carry a high risk of cardiac arrhythmias. This risk is heightened by episodic hyperkalemia. The purpose of the study was to investigate whether patiromer adminis ... Full text Link to item Cite

Sex-Related Differences in Ventricular Tachyarrhythmia Events in Patients With Implantable Cardioverter-Defibrillator and Prior Ventricular Tachyarrhythmias.

Journal Article JACC Clin Electrophysiol · February 2024 BACKGROUND: Data on the risk of ventricular tachycardia (VT), ventricular fibrillation (VF), and death by sex in patients with prior VT/VF are limited. OBJECTIVES: This study aimed to assess sex-related differences in implantable cardioverter-defibrillator ... Full text Link to item Cite

A pilot study of longitudinal changes in neurocognition, white matter hyperintensities, and cortical thickness in atrial fibrillation patients following catheter ablation vs medical management.

Journal Article Heart Rhythm O2 · February 2024 BACKGROUND: Cerebral microembolization and atrophy complicate atrial fibrillation (AF). OBJECTIVES: We aimed to compare changes in neuroimaging findings between AF patients treated with catheter ablation and those treated with medical therapy. METHODS: In ... Full text Link to item Cite

Colchicine for the Prevention of Recurrent Arrhythmia After Catheter Ablation of Atrial Fibrillation: Results of a Single-Center, Retrospective Study.

Journal Article Am J Cardiovasc Drugs · November 2023 BACKGROUND: There is evidence to suggest that colchicine reduces the risk of recurrent atrial fibrillation (AF) after catheter ablation; however, the tolerability and safety of colchicine in routine practice is unknown. METHODS: Patients undergoing cathete ... Full text Link to item Cite

Has the use of concomitant cardiac medications improved over time in primary prevention ICD patients? Insights from the APPRAISE ATP study

Journal Article European Heart Journal · November 1, 2023 Introduction: Patients (pts) implanted with an ICD for a primary prevention (PP) typically receive concomitant medications (meds) to treat LV dysfunction. However, It is not well established whether compliance with guideline-directed medical therapy (GDMT) ... Full text Cite

Heart Rhythm Society Education Council Update.

Journal Article Heart Rhythm · August 2023 Full text Link to item Cite

Catheter ablation of atrial fibrillation: anticipating and avoiding complications.

Journal Article Expert Rev Med Devices · 2023 INTRODUCTION: Atrial fibrillation (AF) ablation is being performed more frequently and more widely at more centers. This stems from several factors including 1) demographic forces leading to an increased prevalence of the arrhythmia; 2) greater availabilit ... Full text Link to item Cite

Effect of Novel Programming on Inappropriate Implantable Cardioverter-Defibrillator Therapy in Patients With Very Low Ejection Fraction (from A MADIT-RIT).

Journal Article Am J Cardiol · November 1, 2022 The Multicenter Automatic Defibrillator Implantation Trial - Reduce Inappropriate Therapy showed a significant reduction in the risk of inappropriate therapy in patients with a programmed high-rate cutoff ≥200 beats per minute or delayed therapy for events ... Full text Link to item Cite

Prevalence and Phenotypic Burden of Monogenic Arrhythmias Using Integration of Electronic Health Records With Genetics.

Journal Article Circ Genom Precis Med · October 2022 BACKGROUND: Inherited primary arrhythmia syndromes and arrhythmogenic cardiomyopathies can lead to sudden cardiac arrest in otherwise healthy individuals. The burden and expression of these diseases in a real-world, well-phenotyped cardiovascular populatio ... Full text Link to item Cite

Acute echocardiographic and hemodynamic response to his-bundle pacing in patients with first-degree atrioventricular block.

Journal Article Ann Noninvasive Electrocardiol · July 2022 BACKGROUND: Atrial pacing and right ventricular (RV) pacing are both associated with adverse outcomes among patients with first-degree atrioventricular block (1°AVB). His-bundle pacing (HBP) provides physiological activation of the ventricle and may be abl ... Full text Link to item Cite

Reduction in Ventricular Tachyarrhythmia Burden in Patients Enrolled in the RAID Trial.

Journal Article JACC Clin Electrophysiol · June 2022 BACKGROUND: The RAID (Ranolazine Implantable Cardioverter-Defibrillator) randomized placebo-controlled trial showed that ranolazine treatment was associated with reduction in recurrent ventricular tachycardia (VT) requiring appropriate implantable cardiove ... Full text Link to item Cite

Leadless pacemaker implantation after lead extraction for cardiac implanted electronic device infection.

Journal Article J Cardiovasc Electrophysiol · March 2022 BACKGROUND: Cardiac implanted electronic device (CIED) pocket and systemic infection remain common complications with traditional CIEDs and are associated with high morbidity and mortality. Leadless pacemakers may be an attractive pacing alternative for ma ... Full text Link to item Cite

Arrhythmic and Mortality Outcomes Among Ischemic Versus Nonischemic Cardiomyopathy Patients Receiving Primary ICD Therapy.

Journal Article JACC Clin Electrophysiol · January 2022 OBJECTIVES: This study sought to determine the association of cardiomyopathy etiology with the likelihood of ventricular arrhythmias, appropriate implantable cardioverter-defibrillator (ICD) therapy, and mortality. BACKGROUND: There are conflicting data on ... Full text Link to item Cite

Optimizing mechanically sensed atrial tracking in patients with atrioventricular-synchronous leadless pacemakers: A single-center experience.

Journal Article Heart Rhythm O2 · October 2021 BACKGROUND: Atrioventricular (AV)-synchronous single-chamber leadless pacing using a mechanical atrial sensing algorithm produced high AV synchrony in clinical trials, but clinical practice experience with these devices has not yet been described. OBJECTIV ... Full text Open Access Link to item Cite

Electrical storm in patients with left ventricular assist devices: Risk factors, incidence, and impact on survival.

Journal Article Heart Rhythm · August 2021 BACKGROUND: Ventricular arrhythmias (VAs) and electrical storm (ES) are recognized complications following left ventricular assist device (LVAD) implantation; however, their association with long term-outcomes remains poorly understood. OBJECTIVE: The purp ... Full text Link to item Cite

Assessment of primary prevention patients receiving an ICD - Systematic evaluation of ATP: APPRAISE ATP.

Journal Article Heart Rhythm O2 · August 2021 BACKGROUND: The value of antitachycardia pacing (ATP) in the overall cohort of primary prevention patients who receive implantable cardioverter-defibrillators (ICDs) remains uncertain. ATP success reported in prior trials potentially included a large numbe ... Full text Link to item Cite

Survival After Implantable Cardioverter-Defibrillator Shocks.

Journal Article J Am Coll Cardiol · May 25, 2021 BACKGROUND: There are conflicting data on the impact of implantable cardioverter-defibrillator (ICD) shocks on subsequent mortality. OBJECTIVES: The aim of this study was to determine whether the arrhythmic substrate leading to ICD therapy or the therapy i ... Full text Link to item Cite

Predicted benefit of an implantable cardioverter-defibrillator: the MADIT-ICD benefit score.

Journal Article Eur Heart J · May 1, 2021 AIMS: The benefit of prophylactic implantable cardioverter-defibrillator (ICD) is not uniform due to differences in the risk of life-threatening ventricular tachycardia (VT)/ventricular fibrillation (VF) and non-arrhythmic mortality. We aimed to develop an ... Full text Link to item Cite

Reassessing the role of antitachycardia pacing in fast ventricular arrhythmias in primary prevention implantable cardioverter-defibrillator recipients: Results from MADIT-RIT.

Journal Article Heart Rhythm · March 2021 BACKGROUND: In Multicenter Automatic Defibrillator Implantation Trial - Reduce Inappropriate Therapy (MADIT-RIT), high-rate cutoff (arm B) and delayed therapy (arm C) reduced the risk of inappropriate implantable cardioverter-defibrillator (ICD) interventi ... Full text Link to item Cite

Pacemakers and Implantable Cardioverter-Defibrillators

Chapter · January 1, 2021 Cardiac implantable electrical devices (CIEDs) refer to implanted devices that deliver therapeutic electrical stimuli and include permanent pacemakers and implantable cardioverter-defibrillators (ICDs). Electrical therapy for cardiac arrhythmias includes l ... Full text Cite

Subcutaneous implantable cardioverter-defibrillator troubleshooting in patients with a left ventricular assist device: A case series and systematic review.

Journal Article Heart Rhythm · September 2020 BACKGROUND: There are limited data on the performance of the subcutaneous implantable cardioverter-defibrillator (S-ICD) in patients with a left ventricular assist device (LVAD). OBJECTIVE: The purpose of this study was to describe the clinical course and ... Full text Link to item Cite

Catheter ablation of atrial fibrillation in cardiac amyloidosis.

Journal Article Pacing Clin Electrophysiol · September 2020 BACKGROUND: Cardiac amyloidosis is a progressive infiltrative disease involving deposition of amyloid fibrils in the myocardium and cardiac conduction system that frequently manifests with heart failure (HF) and arrhythmias, most frequently atrial fibrilla ... Full text Link to item Cite

Cardiovascular Implantable Electronic Device Surgery Following Left Ventricular Assist Device Implantation.

Journal Article JACC Clin Electrophysiol · September 2020 OBJECTIVES: This study sought to determine the indications, characteristics, and outcomes of cardiovascular implantable electronic device (CIED) surgery in patients with LVAD. BACKGROUND: Many patients with a left ventricular assist device (LVAD) will requ ... Full text Link to item Cite

Identification of Undetected Monogenic Cardiovascular Disorders.

Journal Article J Am Coll Cardiol · August 18, 2020 BACKGROUND: Monogenic diseases are individually rare but collectively common, and are likely underdiagnosed. OBJECTIVES: The purpose of this study was to estimate the prevalence of monogenic cardiovascular diseases (MCVDs) and potentially missed diagnoses ... Full text Link to item Cite

Catheter ablation of atrial fibrillation in patients with diabetes mellitus.

Journal Article Heart Rhythm O2 · August 2020 BACKGROUND: Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). Few studies have compared clinical outcomes after catheter ablation between patients with and those without DM. OBJECTIVE: The purpose of this study was to compa ... Full text Open Access Link to item Cite

Lead Extraction for Cardiovascular Implantable Electronic Device Infection in Patients With Left Ventricular Assist Devices.

Journal Article JACC Clin Electrophysiol · June 2020 OBJECTIVES: The goal of this study was to assess the utility of transvenous lead extraction for cardiovascular implantable electronic device (CIED) infection in patients with a left ventricular assist device (LVAD). BACKGROUND: The use of transvenous lead ... Full text Link to item Cite

Focal impulse and rotor modulation of atrial rotors during atrial fibrillation leads to organization of left atrial activation as reflected by waveform morphology recurrence quantification analysis and organizational index.

Journal Article J Arrhythm · April 2020 BACKGROUND: Focal impulse and rotor modulation (FIRM) can cause slowing, organization, and occasionally termination of atrial fibrillation (AF), although results have been mixed. To further characterize changes in AF during rotor ablation, we quantified mo ... Full text Link to item Cite

Safety and efficacy outcomes of left atrial posterior wall isolation compared to pulmonary vein isolation and pulmonary vein isolation with linear ablation for the treatment of persistent atrial fibrillation.

Journal Article Am Heart J · February 2020 BACKGROUND: Pulmonary wall isolation (PWI) is increasingly used as an adjunctive lesion set to compliment pulmonary vein isolation (PVI), especially in patients with persistent atrial fibrillation (AF). The objective was to compare outcomes of catheter abl ... Full text Link to item Cite

Effectiveness of catheter ablation of atrial fibrillation according to heart failure etiology.

Journal Article J Arrhythm · February 2020 BACKGROUND: Catheter ablation is an important rhythm control therapy in patients with atrial fibrillation (AF) with concomitant heart failure (HF). The objective of this study was to assess the comparative efficacy of AF ablation patients with ischemic vs ... Full text Open Access Link to item Cite

Death with an implantable cardioverter-defibrillator: a MADIT-II substudy.

Journal Article Europace · December 1, 2019 AIMS: There are limited data regarding factors that identify implantable cardioverter-defibrillator (ICD) patients who will experience either ventricular tachyarrhythmic (VTA) or non-arrhythmic (NA) mortality, and the commonly used clinical classification ... Full text Link to item Cite

2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy.

Journal Article Heart Rhythm · November 2019 Arrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium not secondary to ischemic, hypertensive, or valvular heart disease. ACM incorporates a broad spectrum of genetic, systemic, infectious, and inflammatory disorders. This des ... Full text Link to item Cite

Predicting atrial fibrillation recurrence after ablation in patients with heart failure: Validity of the APPLE and CAAP-AF risk scoring systems.

Journal Article Pacing Clin Electrophysiol · November 2019 BACKGROUND: Compared with medical therapy, catheter ablation of atrial fibrillation (AF) in patients with heart failure (HF) improves cardiovascular outcomes. Risk scores (CAAP-AF and APPLE) have been developed to predict the likelihood of AF recurrence af ... Full text Open Access Link to item Cite

2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary.

Journal Article Heart Rhythm · November 2019 Arrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium not secondary to ischemic, hypertensive, or valvular heart disease. ACM incorporates a broad spectrum of genetic, systemic, infectious, and inflammatory disorders. This des ... Full text Link to item Cite

Prevalence of atrial fibrillation and association with clinical, sociocultural, and ancestral correlates among Hispanic/Latinos: The Hispanic Community Health Study/Study of Latinos.

Journal Article Heart Rhythm · May 2019 BACKGROUND: Hispanics/Latinos represent the largest ethnic minority group in the United States. Atrial fibrillation (AF) is the most common cardiac arrhythmia in the United States. OBJECTIVE: The purpose of this study was to provide data on the prevalence ... Full text Link to item Cite

New high-density and automated mapping systems

Chapter · April 5, 2019 Three-dimensional electroanatomical mapping (EAM) systems realistically made it feasible to map focal or reentrant arrhythmias from one of the cardiac chambers. The importance of optimized detailed and accurate mapping within the regions previously conside ... Full text Cite

Multimodal imaging for cardiac mapping

Chapter · April 5, 2019 Mapping and elimination (ablation) of an abnormal cardiac rhythm requires an understanding of normal and abnormal anatomy and physiology, and monitoring of the interventional catheters and ablation energy’s effects. Cardiac electrophysiology has evolved en ... Full text Cite

Mapping and ablation of typical and atypical accessory pathways

Chapter · April 5, 2019 Accessory pathways (APs) are one of the longest standing targets for mapping and ablation, previously surgical but now almost exclusively catheter based. This chapter reviews the electrocardiographic and catheter-based principles of mapping related to APs. ... Full text Cite

New Concepts in Sudden Cardiac Arrest to Address an Intractable Epidemic: JACC State-of-the-Art Review.

Journal Article J Am Coll Cardiol · January 8, 2019 Sudden cardiac arrest (SCA) is one of the largest causes of mortality globally, with an out-of-hospital survival below 10% despite intense research. This document outlines challenges in addressing the epidemic of SCA, along the framework of respond, unders ... Full text Link to item Cite

Ablation of Posteroseptal Accessory Pathways

Chapter · January 1, 2019 Posteroseptal accessory pathways (APs) are actually not septal but reside in a complex region bordering the right atrium, right ventricle, left ventricle, left atrium and coronary sinus and its branches. Posteroseptal APs are among the most challenging to ... Full text Cite

Obstructive sleep apnea is associated with increased rotor burden in patients undergoing focal impulse and rotor modification guided atrial fibrillation ablation.

Journal Article Europace · November 1, 2018 AIMS: To assess whether obstructive sleep apnea (OSA) was associated with increased rotor burden among atrial fibrillation (AF) patients. METHODS AND RESULTS: We studied 33 consecutive patients who were scheduled for focal impulse and rotor modulation (FIR ... Full text Link to item Cite

Effectiveness of high rate and delayed detection ICD programming by race: A MADIT-RIT substudy.

Journal Article J Cardiovasc Electrophysiol · October 2018 INTRODUCTION: Data on inappropriate and appropriate ICD therapy, and efficacy of ICD programing strategies by race are limited. METHODS: In MADIT-RIT, we evaluated the risk of ICD therapy by race, and the efficacy of high rate cut-off ventricular tachycard ... Full text Link to item Cite

Ranolazine in High-Risk Patients With Implanted Cardioverter-Defibrillators: The RAID Trial.

Journal Article J Am Coll Cardiol · August 7, 2018 BACKGROUND: Ventricular tachycardia (VT) and ventricular fibrillation (VF) remain a challenging problem in patients with implantable cardioverter-defibrillators (ICDs). OBJECTIVES: This study aimed to determine whether ranolazine administration decreases t ... Full text Link to item Cite

Left bundle branch block-induced left ventricular remodeling and its potential for reverse remodeling.

Journal Article J Interv Card Electrophysiol · August 2018 With the emergence of cardiac resynchronization therapy (CRT) as a powerful tool to reverse left ventricular dysfunction in patients with left bundle branch block (LBBB), there is increasing awareness that LBBB-induced dyssynchrony may be a primary cause o ... Full text Link to item Cite

Pacemaker programming in patients with first-degree AV-block: Programming pattern and possible consequences.

Journal Article Health Sci Rep · June 2018 BACKGROUND: The optimal way of pacing in patients with an indication for pacing and concomitant first-degree atrioventricular (AV)-block is not known, and consequently, firm guidelines on this topic are lacking. This study explored the current pacemaker pr ... Full text Link to item Cite

Arthur J. Moss, MD: In Memoriam.

Journal Article J Am Coll Cardiol · May 22, 2018 Full text Link to item Cite

Catheter ablation of atrial fibrillation in patients with heart failure and preserved ejection fraction.

Journal Article Heart Rhythm · May 2018 BACKGROUND: Few studies have examined outcomes of catheter ablation for atrial fibrillation (AF) in patients with heart failure (HF) with preserved ejection fraction (HFpEF). OBJECTIVE: The purpose of this study was to compare outcomes of AF ablation in pa ... Full text Link to item Cite

Dofetilide dose reductions and discontinuations in women compared with men.

Journal Article Heart Rhythm · April 2018 BACKGROUND: Compared with men, women have longer corrected QT (QTc) intervals, lower clearance of dofetilide, and higher rates of drug-induced torsades de pointes, but the dofetilide dosing algorithm is the same for men and women. OBJECTIVE: The purpose of ... Full text Link to item Cite

Postimplantation ventricular ectopic burden and clinical outcomes in cardiac resynchronization therapy-defibrillator patients: a MADIT-CRT substudy.

Journal Article Ann Noninvasive Electrocardiol · March 2018 BACKGROUND: Frequent ventricular ectopy on preimplantation Holter has been associated with attenuated benefit from cardiac resynchronization therapy (CRT). However, it is unclear whether ectopic burden measured post-CRT implantation can be utilized to eval ... Full text Link to item Cite

Impaired Recovery of Left Ventricular Function in Patients With Cardiomyopathy and Left Bundle Branch Block.

Journal Article J Am Coll Cardiol · January 23, 2018 BACKGROUND: Patients with left bundle branch block (LBBB) often respond to cardiac resynchronization therapy (CRT) with left ventricular ejection fraction (LVEF) improvement. Guideline-directed medical therapy (GDMT), not CRT, is first-line therapy for pat ... Full text Link to item Cite

How to Perform CRT Optimization

Chapter · January 1, 2018 Congestive heart failure (CHF) is a resource-intensive and costly chronic disease. Current indications for implantation of cardiac resynchronization therapy (CRT) include the presence of severe cardiomyopathy and evidence of ventricular conduction delay on ... Full text Cite

How-to Manual for Pacemaker and ICD Devices： Procedures and Programming

Book · January 1, 2018 A complete, how-to-do-it guide to planning, programming, implementing, and trouble-shooting today's pacemakers and other implantable cardiac devices Edited by a team of leading clinician-educators this is a practical, go-to reference for trainees and clini ... Full text Cite

Comparison of Incidence of Left Ventricular Systolic Dysfunction Among Patients With Left Bundle Branch Block Versus Those With Normal QRS Duration.

Journal Article Am J Cardiol · December 1, 2017 We compared the incidence of left ventricular systolic dysfunction (LVSD) among patients with left bundle branch block (LBBB) to a matched cohort of patients with a narrow QRS duration <120 ms (NQRS). We hypothesized patients with preserved ejection fracti ... Full text Link to item Cite

Heart failure severity, inappropriate ICD therapy, and novel ICD programming: a MADIT-RIT substudy.

Journal Article Pacing Clin Electrophysiol · December 2017 BACKGROUND: The effects of heart failure (HF) severity on risk of inappropriate implantable cardioverter-defibrillator (ICD) therapy have not been thoroughly investigated. We aimed to study the association between HF severity and inappropriate ICD therapy ... Full text Link to item Cite

Risk of atrioesophageal fistula formation with contact force-sensing catheters.

Journal Article Heart Rhythm · September 2017 BACKGROUND: Atrioesophageal fistula formation is a rare but life-threatening complication of atrial fibrillation ablation. Contact force (CF)-sensing catheters improve procedural effectiveness. However, the impact of the implementation of CF-sensing techno ... Full text Link to item Cite

Ranolazine reduces atrial fibrillatory wave frequency.

Journal Article Europace · July 1, 2017 AIMS: Antiarrhythmic medications for the treatment of atrial fibrillation (AF) have limited efficacy and rare but potentially life-threatening side effects. Ranolazine is an antianginal agent that may have antiarrhythmic activity in AF. METHODS AND RESULTS ... Full text Link to item Cite

Multicenter Automatic Defibrillator Implantation Trial-Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol.

Journal Article Am Heart J · July 2017 Patients with diabetes mellitus, prior myocardial infarction, older age, and a relatively preserved left ventricular ejection fraction remain at risk for sudden cardiac death that is potentially amenable by the subcutaneous implantable cardioverter defibri ... Full text Link to item Cite

Effects of implantable cardioverter/defibrillator shock and antitachycardia pacing on anxiety and quality of life: A MADIT-RIT substudy.

Journal Article Am Heart J · July 2017 UNLABELLED: Effects of implantable cardioverter/defibrillator (ICD) shocks and antitachycardia pacing (ATP) on anxiety and quality of life (QoL) in ICD patients are poorly understood. METHODS: We evaluated changes in QoL from baseline to 9-month follow-up ... Full text Link to item Cite

Temporal Trends in and Factors Associated With Use of Single- Versus Dual-Coil Implantable Cardioverter-Defibrillator Leads: Data From the NCDR ICD Registry.

Journal Article JACC Clin Electrophysiol · June 2017 OBJECTIVES: This analysis evaluated temporal trends and factors associated with the use of dual-coil implantable cardioverter-defibrillator (ICD) leads. BACKGROUND: Data suggest that dual-coil ICD leads are not associated with lower mortality and can be mo ... Full text Link to item Cite

Multiple Comorbidities and Response to Cardiac Resynchronization Therapy: MADIT-CRT Long-Term Follow-Up.

Journal Article J Am Coll Cardiol · May 16, 2017 BACKGROUND: Data regarding cardiac resynchronization therapy (CRT) in patients with multiple comorbidities are limited. OBJECTIVES: This study evaluated the association of multiple comorbidities with the benefits of CRT over implantable cardioverter-defibr ... Full text Link to item Cite

Sinus Node Dysfunction and Atrial Fibrillation: A Reversible Phenomenon?

Journal Article Pacing Clin Electrophysiol · April 2017 BACKGROUND: Symptomatic sinus node dysfunction (SND) consists of a variety of manifestations, including tachycardia-bradycardia syndrome. Atrial fibrillation (AF) is commonly associated with SND, which complicates the management of both conditions. This pa ... Full text Link to item Cite

Incidence and Predictors of Left Atrial Appendage Thrombus in Patients Treated With Nonvitamin K Oral Anticoagulants Versus Warfarin Before Catheter Ablation for Atrial Fibrillation.

Journal Article Am J Cardiol · April 1, 2017 The utility of routine transesophageal echocardiography (TEE) to exclude left atrial appendage (LAA) thrombus before atrial fibrillation (AF) ablation in patients treated with nonvitamin K oral anticoagulant (NOAC) therapy is unclear. This single-center re ... Full text Link to item Cite

Adverse outcomes associated with postoperative atrial arrhythmias after lung transplantation: A meta-analysis and systematic review of the literature.

Journal Article Clin Transplant · April 2017 BACKGROUND: Postoperative atrial arrhythmias (AAs) are common after lung transplantation, but studies are mixed regarding their impact on outcomes. We therefore performed this systematic review and meta-analysis to determine whether AAs after lung transpla ... Full text Link to item Cite

Recurrent Post-Ablation Paroxysmal Atrial Fibrillation Shares Substrates With Persistent Atrial Fibrillation : An 11-Center Study.

Journal Article JACC Clin Electrophysiol · April 2017 INTRODUCTION: The role of atrial fibrillation (AF) substrates is unclear in patients with paroxysmal AF (PAF) that recurs after pulmonary vein isolation (PVI). We hypothesized that patients with recurrent post-ablation (redo) PAF despite PVI have electrica ... Full text Link to item Cite

Sex Differences in Inappropriate ICD Device Therapies: MADIT-II and MADIT-CRT.

Journal Article J Cardiovasc Electrophysiol · January 2017 INTRODUCTION: Approximately 10-20% of ICD recipients receive inappropriate device therapies. The purpose of this study was to compare the frequency of inappropriate therapies (IT) between men and women enrolled in MADIT II and MADIT-CRT, and assess for pot ... Full text Link to item Cite

Why the Authors Use Cardiac Resynchronization Therapy with Defibrillators.

Journal Article Heart Fail Clin · January 2017 Cardiac resynchronization therapy (CRT) improves left ventricular function, especially in patients with left bundle branch block or those receiving chronic right ventricular pacing. CRT is typically accomplished by placing a right ventricular endocardial p ... Full text Link to item Cite

Permanent His-Bundle Pacing: An Adolescent with Promise.

Journal Article Pacing Clin Electrophysiol · December 2016 Full text Link to item Cite

Association Between a Prolonged PR Interval and Outcomes of Cardiac Resynchronization Therapy: A Report From the National Cardiovascular Data Registry.

Journal Article Circulation · November 22, 2016 BACKGROUND: A prolonged PR interval is common among cardiac resynchronization therapy (CRT) candidates; however, the association between PR interval and outcomes is unclear, and the data are conflicting. METHODS: We conducted inverse probability weighted a ... Full text Link to item Cite

Outcomes 1 Year After Implantable Cardioverter-Defibrillator Lead Abandonment Versus Explantation for Unused or Malfunctioning Leads: A Report from the National Cardiovascular Data Registry.

Journal Article Circ Arrhythm Electrophysiol · July 2016 BACKGROUND: Patients with an unused or malfunctioning implantable cardioverter-defibrillator (ICD) lead may have the lead either abandoned or explanted; yet there are limited data on the comparative acute and longer-term safety of these 2 approaches. METHO ... Full text Link to item Cite

Interleukin-1β gene variants are associated with QTc interval prolongation following cardiac surgery: a prospective observational study.

Journal Article Can J Anaesth · April 2016 BACKGROUND: We characterized cardiac surgery-induced dynamic changes of the corrected QT (QTc) interval and tested the hypothesis that genetic factors are associated with perioperative QTc prolongation independent of clinical and procedural factors. METHOD ... Full text Open Access Link to item Cite

Catheter ablation for ventricular tachycardia (VT) in patients with ischemic heart disease: a systematic review and a meta-analysis of randomized controlled trials.

Journal Article J Interv Card Electrophysiol · March 2016 BACKGROUND: Patients with ischemic heart disease may have implantable cardioverter defibrillators (ICDs) implanted for primary or secondary prevention of sudden cardiac death. Although ICD shocks can be life saving, in some patients, they have been associa ... Full text Link to item Cite

Novel ICD Programming and Inappropriate ICD Therapy in CRT-D Versus ICD Patients: A MADIT-RIT Sub-Study.

Journal Article Circ Arrhythm Electrophysiol · January 2016 BACKGROUND: The Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate therapy (MADIT-RIT) trial showed a significant reduction in inappropriate implantable cardioverter defibrillator (ICD) therapy in patients programmed to high-rate c ... Full text Link to item Cite

Scar burden assessed by Selvester QRS score predicts prognosis, not CRT clinical benefit in preventing heart failure event and death: A MADIT-CRT sub-study.

Journal Article J Electrocardiol · 2016 BACKGROUND: There is a need for improved selection criteria for Cardiac Resynchronization Therapy (CRT). High myocardial scar burden has been associated with worse outcome in CRT patients. It is, however, unclear whether high scar burden ameliorates CRT cl ... Full text Link to item Cite

Cardiac Resynchronization Therapy prevents progression of renal failure in heart failure patients.

Journal Article Indian Pacing Electrophysiol J · 2016 BACKGROUND: The goal of this study is to assess the effect of cardiac resynchronization therapy (CRT) over time on renal function and its impact on mortality. The effect of CRT on renal function in patients with heart failure is not well understood. METHOD ... Full text Link to item Cite

Why the Authors Use Cardiac Resynchronization Therapy with Defibrillators.

Journal Article Card Electrophysiol Clin · December 2015 Cardiac resynchronization therapy (CRT) improves left ventricular function, especially in patients with left bundle branch block or those receiving chronic right ventricular pacing. CRT is typically accomplished by placing a right ventricular endocardial p ... Full text Link to item Cite

Characterization and predictors of first and subsequent inappropriate ICD therapy by heart rate ranges: Result of the MADIT-RIT efficacy analysis.

Journal Article Heart Rhythm · September 2015 BACKGROUND: Data on inappropriate implantable cardioverter-defibrillator (ICD) therapy and effects of programming by heart rate are lacking. OBJECTIVE: We aimed to characterize inappropriate ICD therapy and assess the effects of novel programming by heart ... Full text Link to item Cite

Reduction in Inappropriate ICD Therapy in MADIT-RIT Patients Without History of Atrial Tachyarrhythmia.

Journal Article J Cardiovasc Electrophysiol · August 2015 BACKGROUND: There are limited data whether history of atrial tachyarrhythmia (AT) modifies the risk of inappropriate ICD therapy, or the efficacy of novel ICD programming to reduce inappropriate ICD therapy events. METHODS: In MADIT-RIT, we investigated th ... Full text Link to item Cite

Time-dependent risk reduction of ventricular tachyarrhythmias in cardiac resynchronization therapy patients: a MADIT-RIT sub-study.

Journal Article Europace · July 2015 AIMS: Data on the time-dependent benefit of cardiac resynchronization therapy with defibrillator (CRT-D) compared with a dual-chamber implantable cardioverter-defibrillator (ICD) to reduce death or ventricular tachycardia (VT) or ventricular fibrillation ( ... Full text Link to item Cite

Clinical outcome as a function of the PR-interval-there is virtue in moderation: data from the Duke Databank for cardiovascular disease.

Journal Article Europace · June 2015 AIMS: Recently, a U-shaped association between PR-interval and the risk of developing atrial fibrillation was described, with higher risk in patients with long and short PR-intervals. Little is known regarding the association of PR-interval duration and mo ... Full text Link to item Cite

Localization of pacing and defibrillator leads using standard x-ray views is frequently inaccurate and is not reproducible.

Journal Article J Interv Card Electrophysiol · June 2015 PURPOSE: While the accuracy of roentography for evaluation of lead tip position compared with three-dimensional imaging techniques has been well described, there remains considerable variability in the interpretation of the reproducibility of standard x-ra ... Full text Link to item Cite

Cable externalization and electrical failure of the Riata family of implantable cardioverter-defibrillator leads: A systematic review and meta-analysis.

Journal Article Heart Rhythm · June 2015 BACKGROUND: The Riata class of defibrillator leads were placed under US Food and Drug Association (FDA) advisory as of November 2011 because of high rates of cable externalization (CE) and electrical failure (EF). The overall rates of these complications r ... Full text Open Access Link to item Cite

The association between biventricular pacing and cardiac resynchronization therapy-defibrillator efficacy when compared with implantable cardioverter defibrillator on outcomes and reverse remodelling.

Journal Article Eur Heart J · February 14, 2015 AIMS: Previous studies on biventricular (BIV) pacing and cardiac resynchronization therapy-defibrillator (CRT-D) efficacy have used arbitrarily chosen BIV pacing percentages, and no study has employed implantable cardioverter defibrillator (ICD) patients a ... Full text Link to item Cite

Catheter ablation for ventricular tachycardia in patients with an implantable cardioverter defibrillator (CALYPSO) pilot trial.

Journal Article J Cardiovasc Electrophysiol · February 2015 INTRODUCTION: We conducted this pilot randomized clinical trial to determine the feasibility of a large clinical trial aimed at testing whether early use of catheter ablation of ventricular tachycardia (VT) is superior to antiarrhythmic medications at redu ... Full text Link to item Cite

ECG myocardial scar quantification predicts reverse left ventricular remodeling and survival after cardiac resynchronization therapy implantation: A retrospective pilot study.

Journal Article J Electrocardiol · 2015 INTRODUCTION: Electrocardiographic (ECG) LV scar quantification may improve prediction of CRT response. METHODS AND RESULTS: Data were abstracted in 76 patients who underwent a first CRT implantation at 2 US centers. Selvester QRS scar quantification was p ... Full text Link to item Cite

Novel mechanism of premature battery failure due to lithium cluster formation in implantable cardioverter-defibrillators.

Journal Article Heart Rhythm · December 2014 BACKGROUND: Battery failure is an uncommon complication of implantable cardioverter-defibrillators (ICDs), but unanticipated battery depletion can have life-threatening consequences. OBJECTIVE: The purpose of this study was to describe the prevalence of a ... Full text Link to item Cite

Periprocedural imaging and outcomes after catheter ablation of atrial fibrillation.

Journal Article Heart · December 2014 OBJECTIVE: Catheter ablation of atrial fibrillation (AF) has become an increasingly safe and effective therapy. This has been partly attributed to the use of adjunctive imaging modalities. We aimed to describe the use and associated outcomes of periprocedu ... Full text Link to item Cite

Stability of rotors and focal sources for human atrial fibrillation: focal impulse and rotor mapping (FIRM) of AF sources and fibrillatory conduction.

Journal Article J Cardiovasc Electrophysiol · December 2014 INTRODUCTION: Several groups report electrical rotors or focal sources that sustain atrial fibrillation (AF) after it has been triggered. However, it is difficult to separate stable from unstable activity in prior studies that examined only seconds of AF. ... Full text Link to item Cite

Cardiac implantable electronic device removal in patients with left ventricular assist device associated infections.

Journal Article J Cardiovasc Electrophysiol · November 2014 INTRODUCTION: Heart failure patients with left ventricular assist devices (LVADs) are at risk for infection. Cardiac implantable electronic devices (CIEDs) are commonly present in these patients. The course of infections in patients with an LVAD and a CIED ... Full text Link to item Cite

Mortality reduction in relation to implantable cardioverter defibrillator programming in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT).

Journal Article Circ Arrhythm Electrophysiol · October 2014 BACKGROUND: The benefit of novel implantable cardioverter defibrillator (ICD) programming in reducing inappropriate ICD therapy and mortality was demonstrated in Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT ... Full text Link to item Cite

Preprocedural ECG-gated computed tomography for prevention of complications during lead extraction.

Journal Article Pacing Clin Electrophysiol · October 2014 BACKGROUND: Preprocedural multidetector computed tomography (MDCT) may identify patients at risk for mechanical complications during lead extraction. METHODS: To describe the use and feasibility of computed tomography scanning for preprocedural planning of ... Full text Link to item Cite

Association between frequency of atrial and ventricular ectopic beats and biventricular pacing percentage and outcomes in patients with cardiac resynchronization therapy.

Journal Article J Am Coll Cardiol · September 9, 2014 BACKGROUND: A high percentage of biventricular pacing is required for optimal outcome in patients treated with cardiac resynchronization therapy (CRT), but the influence of ectopic beats on the success of biventricular pacing has not been well established. ... Full text Link to item Cite

Use of antiarrhythmic drug therapy and clinical outcomes in older patients with concomitant atrial fibrillation and coronary artery disease.

Journal Article Europace · September 2014 AIMS: Atrial fibrillation (AF) and coronary artery disease (CAD) are common in older patients. We aimed to describe the use of antiarrhythmic drug (AAD) therapy and clinical outcomes in these patients. METHODS AND RESULTS: We analysed AAD therapy and outco ... Full text Link to item Cite

Adverse effects of first-degree AV-block in patients with sinus node dysfunction: data from the mode selection trial.

Journal Article Pacing Clin Electrophysiol · September 2014 BACKGROUND: Patients with a pacing indication and first-degree atrioventricular (AV)-block pose a clinical challenge. The prognostic impact of first-degree AV-block in patients with sinus node dysfunction and the impact of pacing in this setting are not kn ... Full text Link to item Cite

Initial independent outcomes from focal impulse and rotor modulation ablation for atrial fibrillation: multicenter FIRM registry.

Journal Article J Cardiovasc Electrophysiol · September 2014 INTRODUCTION: The success of pulmonary vein isolation (PVI) for atrial fibrillation (AF) may be improved if stable AF sources identified by Focal Impulse and Rotor Mapping (FIRM) are also eliminated. The long-term results of this approach are unclear outsi ... Full text Link to item Cite

Comparison of safety of sotalol versus amiodarone in patients with atrial fibrillation and coronary artery disease.

Journal Article Am J Cardiol · September 1, 2014 Sotalol is a commonly prescribed antiarrhythmic drug (AAD) used for maintaining sinus rhythm in patients with atrial fibrillation (AF). Although randomized studies have found that sotalol can significantly delay time to AF recurrence, its association with ... Full text Link to item Cite

PR interval identifies clinical response in patients with non-left bundle branch block: a Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy substudy.

Conference Circ Arrhythm Electrophysiol · August 2014 BACKGROUND: In Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT), patients with non-left bundle branch block (LBBB; including right bundle branch block, intraventricular conduction delay) did not have clin ... Full text Link to item Cite

Survival with cardiac-resynchronization therapy in mild heart failure.

Journal Article N Engl J Med · May 1, 2014 BACKGROUND: The Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT) showed that early intervention with cardiac-resynchronization therapy with a defibrillator (CRT-D) in patients with an electrocardiogr ... Full text Link to item Cite

The effect of intermittent atrial tachyarrhythmia on heart failure or death in cardiac resynchronization therapy with defibrillator versus implantable cardioverter-defibrillator patients: a MADIT-CRT substudy (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy).

Journal Article J Am Coll Cardiol · April 1, 2014 OBJECTIVES: This study aimed to investigate the effect of both history of intermittent atrial tachyarrhythmias (IAT) and in-trial IAT on the risk of heart failure (HF) or death comparing cardiac resynchronization therapy with defibrillator (CRT-D) to impla ... Full text Link to item Cite

Association between myocardial substrate, implantable cardioverter defibrillator shocks and mortality in MADIT-CRT.

Journal Article Eur Heart J · January 2014 OBJECTIVE: The aim of the present study was to assess a possible association between myocardial substrate, implantable cardioverter defibrillator (ICD) shocks, and subsequent mortality. METHODS: Within the multicentre automatic defibrillator implantation t ... Full text Link to item Cite

Heart Rhythm Disorders and Resuscitation Science

Conference CIRCULATION · November 26, 2013 Link to item Cite

End-of-life care in patients with implantable cardioverter defibrillators: a MADIT-II substudy.

Journal Article Pacing Clin Electrophysiol · October 2013 BACKGROUND: Implantable cardioverter defibrillator (ICD)-delivered shocks can cause substantial distress, warranting consideration of ICD deactivation at end of life. This study was designed to describe the patterns of end-of-life management in patients wi ... Full text Link to item Cite

ECG quantification of myocardial scar and risk stratification in MADIT-II.

Journal Article Ann Noninvasive Electrocardiol · September 2013 BACKGROUND: Low left ventricular ejection fraction (LVEF) increases risk for both sudden cardiac death (SCD) and for heart failure (HF) death; however, implantable cardioverter-defibrillators (ICDs) reduce the incidence of SCD, not HF death. Distinguishing ... Full text Link to item Cite

Dabigatran for periprocedural anticoagulation following radiofrequency ablation for atrial fibrillation: a meta-analysis of observational studies.

Journal Article J Interv Card Electrophysiol · September 2013 PURPOSE: Dabigatran is approved for prevention of stroke or systemic embolism in patients with nonvalvular atrial fibrillation (AF). The safety and effectiveness of periprocedural dabigatran in ablation for AF are unknown. METHODS: We performed a meta-anal ... Full text Link to item Cite

Impact of using a telescoping-support catheter system for left ventricular lead placement on implant success and procedure time of cardiac resynchronization therapy.

Journal Article Pacing Clin Electrophysiol · May 2013 BACKGROUND: Proper positioning of the left ventricular (LV) lead improves clinical outcomes and survival in patients receiving cardiac resynchronization therapy (CRT). Techniques of LV lead insertion using contrast injection and a telescoping system of del ... Full text Link to item Cite

First-degree AV block-an entirely benign finding or a potentially curable cause of cardiac disease?

Journal Article Ann Noninvasive Electrocardiol · May 2013 First-degree atrioventricular (AV) block is a delay within the AV conduction system and is defined as a prolongation of the PR interval beyond the upper limit of what is considered normal (generally 0.20 s). Up until recently, first-degree AV block was con ... Full text Link to item Cite

Exercise training and implantable cardioverter-defibrillator shocks in patients with heart failure: results from HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing).

Journal Article JACC Heart Fail · April 2013 OBJECTIVES: The purpose of this study was to determine whether exercise training is associated with an increased risk of implantable cardioverter-defibrillator (ICD) therapy in patients with heart failure (HF). BACKGROUND: Few data are available regarding ... Full text Link to item Cite

A clinical trial of ICD programming.

Journal Article N Engl J Med · March 7, 2013 Full text Link to item Cite

Effect of defibrillation threshold testing on heart failure hospitalization or death in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT).

Journal Article Heart Rhythm · February 2013 BACKGROUND: Defibrillation threshold (DFT) testing is commonly practiced at the time of implantable cardioverter-defibrillator (ICD) implant. The clinical consequence of ICD shocks delivered during DFT testing is unknown. OBJECTIVE: The purpose of this stu ... Full text Link to item Cite

Reduction in inappropriate therapy and mortality through ICD programming.

Journal Article N Engl J Med · December 13, 2012 BACKGROUND: The implantable cardioverter-defibrillator (ICD) is highly effective in reducing mortality among patients at risk for fatal arrhythmias, but inappropriate ICD activations are frequent, with potential adverse effects. METHODS: We randomly assign ... Full text Link to item Cite

Outcomes of Medicare beneficiaries undergoing catheter ablation for atrial fibrillation.

Journal Article Circulation · October 30, 2012 BACKGROUND: Atrial fibrillation is common among older persons. Catheter ablation is increasingly used in patients for whom medical therapy has failed. METHODS AND RESULTS: We conducted a retrospective cohort study of all fee-for-service Medicare beneficiar ... Full text Link to item Cite

Race and gender variation in the QT interval and its association with mortality in patients with coronary artery disease: results from the Duke Databank for Cardiovascular Disease (DDCD).

Journal Article Am Heart J · September 2012 BACKGROUND: In several studies, prolongation of the corrected QT (QTc) interval has been associated with an increased risk of cardiac events. However, data on race and gender variation in the QTc and its associated risk of death are lacking. METHODS: We pr ... Full text Link to item Cite

Multicenter automatic defibrillator implantation trial: reduce inappropriate therapy (MADIT-RIT): background, rationale, and clinical protocol.

Journal Article Ann Noninvasive Electrocardiol · July 2012 The implantable cardioverter defibrillator (ICD) is highly effective in reducing mortality due to cardiac arrhythmias in high-risk cardiac patients. However, inappropriate therapies caused predominantly by supraventricular tachyarrhythmias (SVTs) remain a ... Full text Link to item Cite

Implantable cardioverter defibrillators: risks accompany the life-saving benefits.

Journal Article Heart · May 2012 Sudden cardiac arrest is the one of the most common causes of death in developed countries and accounts for between 180,000 and over 450,000 per year in the USA. Antiarrhythmic drug approaches to prevention of sudden cardiac death have been resoundingly in ... Full text Link to item Cite

Expanding the benefits of implantable cardioverter-defibrillator therapy: "is less more"?

Journal Article Prog Cardiovasc Dis · 2012 Implantable cardioverter-defibrillator (ICD) therapy improves survival in patients with significant left ventricular systolic dysfunction. Although this lifesaving therapy has many benefits, inappropriate ICD shocks may increase morbidity and mortality. Wi ... Full text Link to item Cite

Case 126

Journal Article · December 1, 2011 A 51-year-old man on chronic methadone therapy for a history of heroin abuse presented to the emergency room with cough and dyspnea. On exam he was found to be tachypneic and pulse oximetry showed a saturation of 88% on room air and a portable chest X-ray ... Full text Cite

Case 130

Journal Article · December 1, 2011 A 13-year-old boy is being evaluated for syncope. At the time of the syncopal event, he was a national, junior tennis champion, but had recently complained of increased fatigue and shortness of breath while playing tennis. One month previously, his brother ... Full text Cite

Case 146

Journal Article · December 1, 2011 A 19-year-old college swimmer suffered syncope during an intercollegiate race. She described losing consciousness for two seconds, and coming to the surface gasping for air and choking. Over the prior month she had also had 2-3 episodes of palpitations, on ... Full text Cite

Case 166

Journal Article · December 1, 2011 A 6-ft 3-in., 16-year-old male who was a high-school varsity soccer and basketball player was referred to pediatric cardiology to rule out Marfan's syndrome based on his tall slim body habitus and occasional joint aches. The patient denied any history of p ... Full text Cite

Cryoablation of atrial fibrillation.

Journal Article J Interv Card Electrophysiol · December 2011 Atrial fibrillation (AF) is a significant burden to the public health. AF is associated with increased morbidity and mortality, including an increased risk of heart failure, stroke, cognitive impairment, and diminished quality of life. Catheter ablation is ... Full text Link to item Cite

Response to preventive cardiac resynchronization therapy in patients with ischaemic and nonischaemic cardiomyopathy in MADIT-CRT.

Journal Article Eur Heart J · July 2011 Featured Publication AIMS: There are no data regarding the differential response to cardiac resynchronization therapy with defibrillator (CRT-D) by the aetiology of cardiomyopathy in mildly symptomatic patients. We evaluated the outcome of patients enrolled in MADIT-CRT by isc ... Full text Link to item Cite

Tick tock.

Journal Article Am J Med · April 2011 Full text Link to item Cite

Left ventricular lead position and clinical outcome in the multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT) trial.

Journal Article Circulation · March 22, 2011 Featured Publication BACKGROUND: An important determinant of successful cardiac resynchronization therapy for heart failure is the position of the left ventricular (LV) pacing lead. The aim of this study was to analyze the impact of the LV lead position on outcome in patients ... Full text Link to item Cite

Effectiveness of Cardiac Resynchronization Therapy by QRS Morphology in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT).

Journal Article Circulation · March 15, 2011 Featured Publication BACKGROUND: This study aimed to determine whether QRS morphology identifies patients who benefit from cardiac resynchronization therapy with a defibrillator (CRT-D) and whether it influences the risk of primary and secondary end points in patients enrolled ... Full text Link to item Cite

Underutilization of Implantable Cardioverter Defibrillator in Primary Prevention of Sudden Cardiac Arrest.

Journal Article Cardiol Res · February 2011 BACKGROUND: The aim of this study was to evaluate the overall use of implantable cardioverter defibrillators (ICD) for primary prevention of sudden cardiac arrest (SCA), among eligible patients from an outpatient cardiology clinic and to determine what fac ... Full text Link to item Cite

Percutaneous intravascular defibrillator: preliminary data and many questions.

Journal Article Heart Rhythm · February 2011 Featured Publication Full text Link to item Cite

Pulmonary vein contraction before and after radiofrequency ablation for atrial fibrillation.

Journal Article J Cardiovasc Electrophysiol · February 2011 Featured Publication UNLABELLED:   INTRODUCTION: Cardiovascular magnetic resonance imaging (cMRI) may provide a noninvasive method to test for pulmonary vein (PV) isolation after ablation for atrial fibrillation (AF) by detecting changes in PV contraction. METHODS: PV contract ... Full text Link to item Cite

A young patient with exercise-induced polymorphic ventricular tachycardia.

Journal Article Ann Noninvasive Electrocardiol · January 2011 Ann Noninvasive Electrocardiol 2011;16(1):96–99 ... Full text Link to item Cite

Catheter ablation of atrial fibrillation in the elderly.

Journal Article Curr Opin Cardiol · January 2011 Featured Publication PURPOSE OF REVIEW: Atrial fibrillation is increasingly prevalent among older adults and is a major contributor to morbidity in this population due to associated strokes, heart failure, and quality of life impairment. Catheter ablation for atrial fibrillati ... Full text Link to item Cite

Reply

Journal Article American Journal of Cardiology · January 1, 2011 Full text Cite

Clinical predictors of survival in patients treated with therapeutic hypothermia following cardiac arrest.

Journal Article Resuscitation · December 2010 Featured Publication INTRODUCTION: Therapeutic hypothermia has been shown to provide neuroprotection and improved survival in patients suffering a cardiac arrest. We report outcomes of consecutive patients receiving therapeutic hypothermia for cardiac arrest and describe predi ... Full text Link to item Cite

Prevalence and clinical characteristics associated with left atrial appendage thrombus in fully anticoagulated patients undergoing catheter-directed atrial fibrillation ablation.

Journal Article J Cardiovasc Electrophysiol · August 1, 2010 Featured Publication INTRODUCTION: Catheter-directed atrial fibrillation (AF) ablation is contraindicated among patients with left atrial appendage (LAA) thrombus. The prevalence of LAA thrombus among fully anticoagulated patients undergoing AF ablation is unknown. METHODS AND ... Full text Link to item Cite

Meta-analysis of the effect of radiofrequency catheter ablation on left atrial size, volumes and function in patients with atrial fibrillation.

Journal Article Am J Cardiol · May 1, 2010 The effects of radiofrequency catheter ablation (RFCA) on left atrial (LA) size, volumes, and function in patients with atrial fibrillation (AF) are not well understood. The aim of this study was to systematically review the effects of RFCA on LA size, vol ... Full text Link to item Cite

Predictive capability of left atrial size measured by CT, TEE, and TTE for recurrence of atrial fibrillation following radiofrequency catheter ablation.

Journal Article Pacing Clin Electrophysiol · May 2010 Featured Publication BACKGROUND: Recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) has been well established and is in part related to left atrial (LA) size. The purpose of this study was to assess the predictive capability of LA diameter (LA ... Full text Link to item Cite

Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria.

Journal Article Circulation · April 6, 2010 BACKGROUND: In 1994, an International Task Force proposed criteria for the clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) that facilitated recognition and interpretation of the frequently nonspecific clinical featu ... Full text Link to item Cite

Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria.

Journal Article Eur Heart J · April 2010 Featured Publication BACKGROUND: In 1994, an International Task Force proposed criteria for the clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) that facilitated recognition and interpretation of the frequently nonspecific clinical featu ... Full text Link to item Cite

Time-dependent risk of Fidelis lead failure.

Journal Article Am J Cardiol · January 1, 2010 The Medtronic Sprint Fidelis leads (models 6930, 6931, 6948, 6949) are 6.6-F bipolar high-voltage implantable cardioverter-defibrillator electrodes that were first introduced in September 2004. In October 2007, Fidelis leads were removed from the market. W ... Full text Link to item Cite

Physicians' knowledge and attitudes regarding implantable cardioverter-defibrillators.

Journal Article Cardiol J · 2010 BACKGROUND: Information is limited regarding the knowledge and attitudes of physicians typically involved in the referral of patients for implantable cardioverter-defibrillator (ICD) implantation. METHODS: We conducted a survey of primary care physicians a ... Link to item Cite

Relation of 12-lead electrocardiogram patterns to implanted defibrillator-terminated ventricular tachyarrhythmias in hypertrophic cardiomyopathy.

Journal Article Am J Cardiol · December 15, 2009 Electrocardiographic (ECG) abnormalities are common in hypertrophic cardiomyopathy (HC) and have been associated with the distribution of left ventricular hypertrophy and myocardial fibrosis. Such abnormalities may predispose patients to electrophysiologic ... Full text Link to item Cite

Right ventricular dysfunction and the incidence of implantable cardioverter-defibrillator therapies.

Journal Article Pacing Clin Electrophysiol · December 2009 INTRODUCTION: Implantable cardioverter-defibrillator (ICD) therapy is well established in preventing sudden cardiac death in patients with left ventricular dysfunction. The influence of right ventricular (RV) function on ICD therapy for sudden cardiac deat ... Full text Link to item Cite

Cardiac-resynchronization therapy for the prevention of heart-failure events.

Journal Article N Engl J Med · October 1, 2009 Featured Publication BACKGROUND: This trial was designed to determine whether cardiac-resynchronization therapy (CRT) with biventricular pacing would reduce the risk of death or heart-failure events in patients with mild cardiac symptoms, a reduced ejection fraction, and a wid ... Full text Link to item Cite

Rationale and design for the Defibrillators to Reduce Risk by Magnetic Resonance Imaging Evaluation (DETERMINE) trial.

Journal Article J Cardiovasc Electrophysiol · September 2009 Featured Publication BACKGROUND: Cardiac magnetic resonance imaging (CMR) can accurately determine infarct size. Prior studies using indirect methods and CMR to assess infarct size have shown that patients with larger myocardial infarctions have worse prognoses. Implantable ca ... Full text Link to item Cite

Direct His bundle pacing post AVN ablation.

Journal Article Pacing Clin Electrophysiol · August 2009 Atrioventricular nodal (AVN) ablation with concomitant pacemaker implantation is one of the strategies that reduce symptoms in patients with atrial fibrillation (AF). However, the long-term adverse effects of right ventricular (RV) apical pacing have led t ... Full text Link to item Cite

Why are (only) some infarcted hearts arrhythmogenic?

Journal Article J Am Coll Cardiol · July 7, 2009 Featured Publication Full text Link to item Cite

Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: results from the North American Multidisciplinary Study.

Journal Article Heart Rhythm · July 2009 Featured Publication BACKGROUND: Prior reports on patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) focused on individuals with advanced forms of the disease. Data on the diagnostic performance of various testing modalities in newly identified in ... Full text Link to item Cite

Effect of biventricular pacing during a ventricular sensed event.

Journal Article Am J Cardiol · June 15, 2009 Loss of biventricular (BiV) pacing occurs during ventricular sensed events such as frequent ventricular ectopy, nonsustained ventricular tachycardia, and intrinsic atrioventricular nodal conduction, such as in atrial fibrillation. Ventricular sense respons ... Full text Link to item Cite

Ventricular arrhythmia inducibility predicts subsequent ICD activation in nonischemic cardiomyopathy patients: a DEFINITE substudy.

Journal Article Pacing Clin Electrophysiol · June 2009 Featured Publication OBJECTIVES: We evaluated whether electrophysiologic (EP) inducibility predicts the subsequent occurrence of spontaneous ventricular tachycardia (VT) or ventricular fibrillation (VF) in the Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation ( ... Full text Link to item Cite

Identification of a retained intravascular wire by three-dimensional transesophageal echocardiography.

Journal Article Echocardiography · April 2009 A 78-year-old man with an implantable cardioverter-defibrillator (ICD) for ischemic cardiomyopathy and prior ventricular tachycardia (VT) ablation presented with abdominal pain and was found to have a small bowel obstruction requiring immediate surgery. Hi ... Full text Link to item Cite

In reply

Journal Article Cleveland Clinic Journal of Medicine · March 2, 2009 Full text Cite

Cardiac resynchronization therapy in heart failure patients: an update.

Journal Article Cardiol J · 2009 Heart failure continues to be a major public health problem with high morbidity and mortality rates, despite the advances in medical treatment. Advanced heart failure patients have severe persistent symptoms and a poor quality of life. Cardiac resynchroniz ... Link to item Cite

Catheter ablation of atrial fibrillation in the elderly: where do we stand?

Journal Article Cardiol J · 2009 Catheter ablation has emerged as an important therapy for the management of drug refractory symptomatic paroxysmal and persistent atrial fibrillation (AF). Although the elderly account for the majority of patients with AF, limited data exists regarding the ... Link to item Cite

To the response

Journal Article PACE Pacing and Clinical Electrophysiology · November 1, 2008 Full text Cite

Physicians' preferences and attitudes about end-of-life care in patients with an implantable cardioverter-defibrillator.

Journal Article Mayo Clin Proc · October 2008 Clinical guidance is deficient regarding deactivation of implantable cardioverter-defibrillators (ICDs) in patients with terminal illnesses. We hypothesized that many physicians are apprehensive about discussing ICD deactivation with their dying patients. ... Full text Link to item Cite

Reply

Journal Article Journal of the American College of Cardiology · September 16, 2008 Full text Cite

Mystery of biphasic defibrillation waveform efficacy is it calcium?

Journal Article J Am Coll Cardiol · September 2, 2008 Featured Publication Full text Link to item Cite

Time dependence of arrhythmias in ICD patients.

Journal Article J Cardiovasc Electrophysiol · August 2008 Full text Link to item Cite

Congenital long QT syndrome: considerations for primary care physicians.

Journal Article Cleve Clin J Med · August 2008 Featured Publication Congenital long QT syndrome is an inherited disorder of cardiac repolarization that predisposes to syncope and to sudden death from polymorphic ventricular tachycardia. The disorder should be suspected when the electrocardiogram shows characteristic QT abn ... Full text Link to item Cite

Acute and long-term efficacy and safety of catheter cryoablation of the cavotricuspid isthmus for treatment of type 1 atrial flutter.

Journal Article Heart Rhythm · July 2008 Featured Publication BACKGROUND: Atrial flutter (AFL) is commonly treated by radiofrequency catheter ablation. Catheter-based cryoablation may be an effective alternative with potential advantages. OBJECTIVE: The purpose of this study was to study the acute and long-term safet ... Full text Link to item Cite

Association of prolonged QRS duration with ventricular tachyarrhythmias and sudden cardiac death in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II).

Journal Article Heart Rhythm · June 2008 BACKGROUND: There is conflicting literature on the relationship between prolonged QRS duration (QRSd) and arrhythmic events, including sudden cardiac death (SCD), in heart failure patients with or without implantable cardioverter-defibrillators (ICDs). OBJ ... Full text Link to item Cite

Inappropriate implantable cardioverter-defibrillator shocks in MADIT II: frequency, mechanisms, predictors, and survival impact.

Journal Article J Am Coll Cardiol · April 8, 2008 Featured Publication OBJECTIVES: This study sought to identify the incidence and outcome related to inappropriate implantable cardioverter-defibrillator (ICD) shocks, that is, those for nonventricular arrhythmias. BACKGROUND: The MADIT (Multicenter Automatic Defibrillator Impl ... Full text Link to item Cite

Defibrillation coil reversal: a rare cause of abnormal noise and inappropriate shocks.

Journal Article Pacing Clin Electrophysiol · March 2008 We report a rare case of inadvertent reversal of the defibrillator shock coils during generator change which then resulted in both intermittent, recurrent "noise" on both the rate sensing and the shock electrogram leads and multiple inappropriate shocks. ... Full text Link to item Cite

Mechanisms of ventricular fibrillation initiation in MADIT II patients with implantable cardioverter defibrillators.

Journal Article Pacing Clin Electrophysiol · February 2008 Featured Publication BACKGROUND: The availability of stored intracardiac electrograms from implantable defibrillators (ICDs) has facilitated the study of the mechanisms of ventricular tachyarrhythmia onset. This study aimed to determine the patterns of initiation of ventricula ... Full text Link to item Cite

Role of magnetic resonance imaging in arrhythmogenic right ventricular dysplasia: insights from the North American arrhythmogenic right ventricular dysplasia (ARVD/C) study.

Journal Article Am Heart J · January 2008 Featured Publication BACKGROUND: Prior reports describing magnetic resonance (MR) imaging abnormalities in arrhythmogenic right ventricular dysplasia (ARVD/C) were limited by nonuniform inclusion criteria. The aim of our study was to define the prevalence, sensitivity, and spe ... Full text Link to item Cite

Metaanalysis on effects of cardiac resynchronization therapy in heart failure patients with narrow QRS complex.

Journal Article Cardiol J · 2008 BACKGROUND: To systematically review the benefits of cardiac resynchronization therapy (CRT) in heart failure patients with narrow QRS (< 120 ms) who have baseline mechanical asynchrony. METHODS: We searched the MEDLINE, Cochrane Central Register of Contro ... Link to item Cite

Risks and challenges of implantable cardioverter-defibrillators in young adults.

Journal Article Prog Cardiovasc Dis · 2008 Featured Publication The clinical use of the implantable cardioverter-defibrillator (ICD) is well established to prevent sudden death in patients with left ventricular dysfunction due to coronary artery disease and dilated cardiomyopathy, and its use has saved thousands of liv ... Full text Link to item Cite

Moxifloxacin-induced torsades de pointes.

Journal Article Cardiol J · 2008 Torsade de pointes (TdP) is increasingly recognized as a complication of drug therapy. The most common cause of drug-induced QT prolongation is inhibition of the rapidly activating component of the delayed potassium current (I(Kr)). Moxifloxacin, a widely ... Link to item Cite

A covariance-based algorithm: a novel technique for rhythm discrimination in ICDs.

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2008 Inappropriate shocks due to misclassification of supraventricular and ventricular arrhythmias remain a major problem in the care of patients with Implantable Cardioverter defibrillators (ICDs). In this study we have investigated the ability of a new covari ... Full text Link to item Cite

Electrophysiologic study including electroanatomic mapping

Journal Article · December 1, 2007 Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is an inherited heart muscle disease characterized by specific right ventricular (RV) involvement and risk of arrhythmic sudden death [1-3]. Distinctive pathologic feature is RV myocardial ... Full text Cite

Ventricular arrhythmia storms in postinfarction patients with implantable defibrillators for primary prevention indications: a MADIT-II substudy.

Journal Article Heart Rhythm · November 2007 Featured Publication BACKGROUND: Much of prognostic implications of ventricular arrhythmia storms remain unclear. OBJECTIVE: We evaluated the risk associated with electrical storm in patients with defibrillators in the Multicenter Automatic Defibrillator Implantation Trial II ... Full text Link to item Cite

Iatrogenic left atrial tachycardias: where are we?

Journal Article J Am Coll Cardiol · October 30, 2007 Featured Publication Full text Link to item Cite

Improved survival associated with prophylactic implantable defibrillators in elderly patients with prior myocardial infarction and depressed ventricular function: a MADIT-II substudy.

Journal Article J Cardiovasc Electrophysiol · August 2007 Featured Publication INTRODUCTION: We aim to evaluate the mortality benefit from defibrillator therapy in eligible elderly patients. Effective primary prevention of sudden cardiac death with implantable cardioverter defibrillators is well demonstrated in patients with coronary ... Full text Link to item Cite

Implantable cardioverter-defibrillators and prevention of sudden cardiac death in hypertrophic cardiomyopathy.

Journal Article JAMA · July 25, 2007 Featured Publication CONTEXT: Recently, the implantable cardioverter-defibrillator (ICD) has been promoted for prevention of sudden death in hypertrophic cardiomyopathy (HCM). However, the effectiveness and appropriate selection of patients for this therapy is incompletely res ... Full text Link to item Cite

Role of implantable cardioverter defibrillator therapy in patients with long QT syndrome.

Journal Article Am Heart J · April 2007 Featured Publication Long QT syndrome (LQTS) is one of several primary electrical disorders or hereditary arrhythmia syndromes along with the short QT syndrome, Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia. Since its initial recognition in 1957 b ... Full text Link to item Cite

Comparison of outcomes in patients undergoing defibrillation threshold testing at the time of implantable cardioverter-defibrillator implantation versus no defibrillation threshold testing.

Journal Article Cardiol J · 2007 BACKGROUND: Inability to perform defibrillation threshold (DFT) testing during implantable cardioverter defibrillator (ICD) implantation due to co-morbidities may influence long-term survival. METHODS: Retrospective review at The University of Michigan (19 ... Link to item Cite

Variation in left atrial transmural wall thickness at sites commonly targeted for ablation of atrial fibrillation.

Journal Article J Interv Card Electrophysiol · November 2006 BACKGROUND: The number of catheter ablations performed for atrial fibrillation (AF) has increased dramatically over the past several years. Regional variation in left atrial (LA) wall thickness is known to exist but have not been described in detail. AF ab ... Full text Link to item Cite

Cigarette smoking and the risk of supraventricular and ventricular tachyarrhythmias in high-risk cardiac patients with implantable cardioverter defibrillators.

Journal Article J Cardiovasc Electrophysiol · September 2006 INTRODUCTION: Nicotine elevates serum catecholamine concentration and is therefore potentially arrhythmogenic. However, the effect of cigarette smoking on arrhythmic risk in coronary heart disease patients is not well established. METHODS AND RESULTS: The ... Full text Link to item Cite

Implantable cardioverter-defibrillator therapy and risk of congestive heart failure or death in MADIT II patients with atrial fibrillation.

Journal Article Heart Rhythm · June 2006 BACKGROUND: Atrial fibrillation (AF) contributes to increased risk of morbidity and mortality. Data regarding the effectiveness of implantable cardioverter-defibrillator (ICD) therapy in AF patients are limited. OBJECTIVES: The purpose of this study was to ... Full text Link to item Cite

Are implantable cardioverter defibrillator shocks a surrogate for sudden cardiac death in patients with nonischemic cardiomyopathy?

Journal Article Circulation · February 14, 2006 BACKGROUND: Ventricular tachyarrhythmias long enough to cause implantable cardioverter defibrillator (ICD) shocks are generally thought to progress to cardiac arrest. In previous ICD trials, shocks have been considered an appropriate surrogate for sudden c ... Full text Link to item Cite

Predictive value of ventricular arrhythmia inducibility for subsequent ventricular tachycardia or ventricular fibrillation in Multicenter Automatic Defibrillator Implantation Trial (MADIT) II patients.

Journal Article J Am Coll Cardiol · January 3, 2006 Featured Publication UNLABELLED: In the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II, implantable cardioverter-defibrillator (ICD)-randomized patients underwent electrophysiologic testing. Both inducible and noninducible patients received an ICD. We correl ... Full text Link to item Cite

Implantable cardioverter-defibrillators for primary prevention: how do the data pertain to the aged?

Journal Article Am J Geriatr Cardiol · 2006 The incidence of sudden cardiac death increases with age and the proportion of the US population in progressively more advanced age strata is dramatically increasing. While several randomized controlled trials support the use of implantable cardioverter-de ... Full text Link to item Cite

Cardiac resynchronization with sequential biventricular pacing for the treatment of moderate-to-severe heart failure.

Journal Article J Am Coll Cardiol · December 20, 2005 OBJECTIVES: The InSync III study evaluated sequential cardiac resynchronization therapy (CRT) in patients with moderate-to-severe heart failure and prolonged QRS. BACKGROUND: Simultaneous CRT improves hemodynamic and clinical performance in patients with m ... Full text Link to item Cite

Safety of transvenous cardiac resynchronization system implantation in patients with chronic heart failure: combined results of over 2,000 patients from a multicenter study program.

Journal Article J Am Coll Cardiol · December 20, 2005 Featured Publication OBJECTIVES: The purpose of this study was to evaluate the safety of implanting a cardiac resynchronization therapy (CRT) system. BACKGROUND: Clinicians and patients require data on the safety of the CRT implant procedure to estimate procedural risk. METHOD ... Full text Link to item Cite

Factors influencing appropriate firing of the implanted defibrillator for ventricular tachycardia/fibrillation: findings from the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II).

Journal Article J Am Coll Cardiol · November 1, 2005 Featured Publication OBJECTIVES: The purpose of this study was to prospectively examine the role of clinical, laboratory, echocardiographic, and electrophysiological variables as predictors of appropriate initial implantable cardioverter-defibrillator (ICD) therapy for ventric ... Full text Link to item Cite

Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol.

Journal Article Ann Noninvasive Electrocardiol · October 2005 The planned MADIT-CRT trial is designed to determine if CRT-D will reduce the risk of mortality and HF events by approximately 25% in subjects with ischemic (NYHA class I-II) and non-ischemic (NYHA class II) cardiomyopathy, left ventricular dysfunction (EF ... Full text Link to item Cite

Safety and efficacy of flecainide in subjects with Long QT-3 syndrome (DeltaKPQ mutation): a randomized, double-blind, placebo-controlled clinical trial.

Journal Article Ann Noninvasive Electrocardiol · October 2005 Featured Publication BACKGROUND: We conducted a study of chronic therapy with flecainide versus placebo in a small group of LQT-3 patients with the DeltaKPQ deletion to evaluate the safety and efficacy of flecainide in this genetic disorder. In vitro studies have shown that fl ... Full text Link to item Cite

Effects of beta-blockers on implantable cardioverter defibrillator therapy and survival in the patients with ischemic cardiomyopathy (from the Multicenter Automatic Defibrillator Implantation Trial-II).

Journal Article Am J Cardiol · September 1, 2005 This study examined the effects of beta blockers on (1) appropriate implantable cardioverter defibrillator (ICD) therapy for ventricular tachycardia (VT) or ventricular fibrillation (VF), (2) inappropriate ICD therapy for atrial fibrillation or supraventri ... Full text Link to item Cite

Venous thrombosis and stenosis after implantation of pacemakers and defibrillators.

Journal Article J Interv Card Electrophysiol · June 2005 Venous complications of pacemaker/ implantable cardioverter defibrillator (ICD) system implantation rarely cause immediate clinical problems. The challenge starts when patients come for system revision or upgrade. Numerous reports of venous complications s ... Full text Link to item Cite

The clinical implications of cumulative right ventricular pacing in the multicenter automatic defibrillator trial II.

Journal Article J Cardiovasc Electrophysiol · April 2005 Featured Publication INTRODUCTION: This study was designed to assess whether right ventricular pacing in the implantable cardioverter defibrillator (ICD) arm of the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II was associated with an unfavorable outcome. ME ... Full text Link to item Cite

Performance of a new cardiac cryoablation system in the treatment of cavotricuspid valve isthmus-dependent atrial flutter.

Journal Article Pacing Clin Electrophysiol · January 2005 Featured Publication We sought to evaluate prospectively the safety and efficacy of cryothermal energy to ablate typical atrial flutter (AFL). Ablation of cardiac tissue using cryothermal energy has recently been developed as an alternative to radiofrequency energy, which may ... Full text Link to item Cite

Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator.

Journal Article Circulation · December 21, 2004 BACKGROUND: The implanted cardioverter defibrillator (ICD) improves survival in high-risk cardiac patients. This analysis from the MADIT-II trial database examines the long-term clinical course and subsequent mortality risk of patients after termination of ... Full text Link to item Cite

Update on implantable cardioverter defibrillator trials.

Journal Article Curr Cardiol Rep · September 2004 Many randomized trials of implantable cardioverter defibrillator (ICD) therapy versus medical treatment for the prevention of death in survivors of cardiac arrest or in patients at high risk of sudden cardiac death (SCD) have been reported. ICD therapy has ... Full text Link to item Cite

Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy.

Journal Article N Engl J Med · May 20, 2004 Featured Publication BACKGROUND: Patients with nonischemic dilated cardiomyopathy are at substantial risk for sudden death from cardiac causes. However, the value of prophylactic implantation of an implantable cardioverter-defibrillator (ICD) to prevent sudden death in such pa ... Full text Link to item Cite

Analysis of cause-specific mortality in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study.

Journal Article Circulation · April 27, 2004 BACKGROUND: Expectations that reestablishing and maintaining sinus rhythm in patients with atrial fibrillation might improve survival were disproved in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. This report describ ... Full text Link to item Cite

Temporal complexity of repolarization and mortality in patients with implantable cardioverter defibrillators.

Journal Article Pacing Clin Electrophysiol · October 2003 Increased repolarization variability has been observed in various cardiac conditions. However, data on its relation to heart rate variability and on its value in predicting adverse outcomes in high risk patients are limited. Forty-seven patients with decre ... Full text Link to item Cite

Implantable cardioverter defibrillator in high-risk long QT syndrome patients.

Journal Article J Cardiovasc Electrophysiol · April 2003 Featured Publication INTRODUCTION: Implantable cardioverter defibrillators (ICDs) are increasingly being used in high-risk long QT syndrome (LQTS) patients, but there are limited data regarding clinical experience with this therapeutic modality. The aim of this study is to des ... Full text Link to item Cite

MADIT-II: clinical implications.

Journal Article Card Electrophysiol Rev · December 2002 Featured Publication The MADIT-II trial showed that in patients with a prior myocardial infarction and ejection fraction Full text Link to item Cite

Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction.

Journal Article N Engl J Med · March 21, 2002 Featured Publication BACKGROUND: Patients with reduced left ventricular function after myocardial infarction are at risk for life-threatening ventricular arrhythmias. This randomized trial was designed to evaluate the effect of an implantable defibrillator on survival in such ... Full text Link to item Cite

Fractal correlation properties of heart rate dynamics and adverse events in patients with implantable cardioverter-defibrillators.

Journal Article Am J Cardiol · July 1, 2001 The aim of this study was to determine the prognostic significance of nonlinear and standard heart rate (HR) variability parameters in predicting future adverse events (AEs) in patients with implantable cardioverter-defibrillators. In postinfarction studie ... Full text Link to item Cite

Rationale and design of a randomized clinical trial to assess the safety and efficacy of cardiac resynchronization therapy in patients with advanced heart failure: the Multicenter InSync Randomized Clinical Evaluation (MIRACLE).

Journal Article J Card Fail · December 2000 Up to 50% of patients with chronic systolic heart failure have interventricular conduction delays, such as left bundle branch block, that result in abnormal electrical depolarization of the heart. Prolonged QRS duration results in abnormal interventricular ... Full text Link to item Cite

Efficacy of implantable cardioverter-defibrillators for the prevention of sudden death in patients with hypertrophic cardiomyopathy.

Journal Article N Engl J Med · February 10, 2000 BACKGROUND: Hypertrophic cardiomyopathy is a genetic disease associated with a risk of ventricular tachyarrhythmias and sudden death, especially in young patients. METHODS: We conducted a retrospective multicenter study of the efficacy of implantable cardi ... Full text Link to item Cite

Wavelet analysis of spatial dispersion of P-wave morphology in patients converted from atrial fibrillation

Journal Article Computers in Cardiology · December 1, 1999 Identifying patients at risk for atrial fibrillation (AF) is a major task of noninvasive electrophysiology. In this study, we aimed to evaluate the usefulness of a wavelet transformation method describing spatial dispersion of time-frequency components of ... Cite

Head-up tilt-table testing: An overview

Journal Article Annals of Noninvasive Electrocardiology · July 13, 1999 Full text Cite

Multicenter automatic defibrillator implantation trial II (MADIT II): Design and clinical protocol

Journal Article Annals of Noninvasive Electrocardiology · February 10, 1999 Full text Cite

Y2K: effects on pacemaker and implantable defibrillator programmers.

Journal Article Heart Lung · 1999 All permanent pacemakers and implantable defibrillators (PPM/ICDs) will continue to function as programmed without regard to the date in the year 2000 (Y2K). All manufacturers contacted reassured us that some of these devices incorporate a day/year clock i ... Full text Link to item Cite

Synthesis and biological activity of a novel methylamine-bridged enkephalin analogue (MABE): a new route to cyclic peptides and peptidomimetics.

Journal Article J Med Chem · July 2, 1998 The synthesis and biological activity of a methylamine-bridged enkephalin analogue (MABE) is presented. The key step in the synthesis of the target compound involves the ring opening of Cbz-d-serine beta-lactone with Boc-Phe-NHCH2CH2NHCH3. Further syntheti ... Full text Link to item Cite

A comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias.

Journal Article N Engl J Med · November 27, 1997 BACKGROUND: Patients who survive life-threatening ventricular arrhythmias are at risk for recurrent arrhythmias. They can be treated with either an implantable cardioverter-defibrillator or antiarrhythmic drugs, but the relative efficacy of these two treat ... Full text Link to item Cite

Nonsustained ventricular tachycardia: Current evaluation and management

Journal Article Annals of Noninvasive Electrocardiology · April 24, 1997 Nonsustained ventricular tachycardia (VT) has been an intimidating diagnosis for many physicians because its presence, in general, portends an increased risk of sudden death. The management and approach has been quite diverse and inconsistent in part due t ... Full text Cite

Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter Automatic Defibrillator Implantation Trial Investigators.

Journal Article N Engl J Med · December 26, 1996 BACKGROUND: Unsustained ventricular tachycardia in patients with previous myocardial infarction and left ventricular dysfunction is associated with a two-year mortality rate of about 30 percent. We studied whether prophylactic therapy with an implanted car ... Full text Link to item Cite

Ventricular tachycardia induced cardiomyopathy: improvement with radiofrequency ablation.

Journal Article Pacing Clin Electrophysiol · April 1996 Cardiomyopathy and congestive heart failure due to ventricular and supraventricular tachycardia is a well-recognized phenomenon. The mechanism of such cardiomyopathy is not clear. Ablation of the supraventricular tachycardia focus, either surgically or ele ... Full text Link to item Cite

Antiarrhythmic agents in older patients. Current state of knowledge.

Journal Article Drugs Aging · June 1994 The treatment of ventricular arrhythmias in the elderly population is a challenging problem. Elderly patients are more predisposed to arrhythmias, are less responsive to antiarrhythmic agents and are more susceptible to the adverse effects of antiarrhythmi ... Full text Link to item Cite

Strength-interval curves in canine myocardium at very short cycle lengths.

Journal Article Pacing Clin Electrophysiol · May 1994 While ventricular electrophysiological properties have been intensively studied at normal heart rates, little is known about these properties at the very short cycle lengths (approximately 100 msec), which are present in ventricular fibrillation. We examin ... Full text Link to item Cite

Complete heart block complicating retrograde left ventricular catheterization: case report and review.

Journal Article Cathet Cardiovasc Diagn · February 1994 Complete heart block (CHB) following retrograde left ventricular catheterization is uncommon. We report a case of transient CHB in a patient with severe aortic stenosis and bifascicular block on the baseline surface electrocardiogram during retrograde left ... Full text Link to item Cite

A fatal case of constrictive pericarditis due to a marked, selective pericardial accumulation of amyloid.

Journal Article Am J Med · March 1993 Distinguishing constrictive pericarditis from restrictive cardiomyopathy, usually due to amyloidosis, is a relatively frequent and difficult diagnostic problem. This report describes, for the first time, a patient with constrictive pericarditis caused by d ... Full text Link to item Cite

Epicardial mapping of ventricular defibrillation with monophasic and biphasic shocks in dogs.

Journal Article Circ Res · January 1993 To study the mechanism of defibrillation and the reason for the increased defibrillation efficacy of biphasic waveforms, the potential gradient in a 32 x 30-mm region of the right ventricle in 15 dogs was progressively lowered in four steps while a strong ... Full text Link to item Cite

High and low strength nonsynchronized shocks given during canine ventricular tachycardia.

Journal Article Pacing Clin Electrophysiol · July 1992 UNLABELLED: Cardioversion shocks given during ventricular tachycardia may cause ventricular fibrillation or acceleration of ventricular tachycardia, or arrest the tachycardia. A recently proposed theory may explain why the former two phenomena may occur. B ... Full text Link to item Cite

Response of relatively refractory canine myocardium to monophasic and biphasic shocks.

Journal Article Circulation · December 1991 Featured Publication BACKGROUND: Certain biphasic waveforms defibrillate at lower energies than monophasic waveforms, although the mechanism is unknown. METHODS AND RESULTS: The relative ability of monophasic and biphasic shocks to stimulate partially refractory myocardium was ... Full text Link to item Cite

Conduction disturbances caused by high current density electric fields.

Journal Article Circ Res · May 1990 During internal defibrillation, potential gradients greater than 100 V/cm occur near defibrillation electrodes. Such strong fields may cause deleterious effects, including arrhythmias. This study determined 1) the effects of such strong fields on the propa ... Full text Link to item Cite

Tear flow analysis through the upper and lower systems.

Journal Article Ophthalmic Plast Reconstr Surg · 1990 Using quantitative lacrimal scintillography, tear flow in the normal state was analyzed in 11 asymptomatic volunteers. The results were compared to states with the superior punctum occluded, and to those with the inferior punctum occluded. No significant d ... Full text Link to item Cite

THE EDGE EFFECT OF CATHETER ELECTRODES

Conference PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY · April 1, 1988 Link to item Cite

BIPHASIC SHOCKS EXCITE REFRACTORY MYOCARDIUM LESS EFFECTIVELY THAN MONOPHASIC SHOCKS

Conference PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY · April 1, 1988 Link to item Cite