Scholars@Duke
James Morizio

James Morizio

Adjunct Professor in the Department of Electrical and Computer Engineering
Electrical and Computer Engineering
jmorizio@ee.duke.edu
Box 90291, Durham, NC 27708-0291
219 Hudson Hall, Durham, NC 27708

Selected Publications

Vagal blockade of the brain-liver axis deters cancer-associated cachexia.

Journal Article Cell · October 16, 2025 Cancer-associated cachexia (CAC) is a multifactorial and currently incurable syndrome responsible for nearly one-third of cancer-related deaths. It contributes to therapy resistance and increases mortality among affected patients. In this study, we show th ... Full text Open Access Link to item Cite

Rapid and comprehensive detection of viral antibodies and nucleic acids via an acoustofluidic integrated molecular diagnostics chip: AIMDx.

Journal Article Science advances · January 2025 Precise and rapid disease detection is critical for controlling infectious diseases like COVID-19. Current technologies struggle to simultaneously identify viral RNAs and host immune antibodies due to limited integration of sample preparation and detection ... Full text Open Access Cite

Pre-clinical development of a wireless neural interface system for osseointegrated prosthetic control in sheep.

Journal Article Frontiers in neuroscience · January 2025 The Osseointegrated Neural Interface (ONI) is an innovative peripheral nerve interface design that houses a transected nerve and coupled electrical components within the medullary canal of long bones for eventual prosthetic control. Before the ONI can ente ... Full text Open Access Cite

Design and Simulation of a Low Power 384-channel Actively Multiplexed Neural Interface.

Conference IEEE Biomedical Circuits and Systems Conference : healthcare technology : [proceedings]. IEEE Biomedical Circuits and Systems Conference · October 2022 Brain computer interfaces (BCIs) provide clinical benefits including partial restoration of lost motor control, vision, speech, and hearing. A fundamental limitation of existing BCIs is their inability to span several areas (> cm2) of the cortex ... Full text Open Access Cite

An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention.

Journal Article Frontiers in human neuroscience · January 2021 Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces (BCIs) should ideally operate un-tet ... Full text Open Access Cite

Hardware Design and Fault-Tolerant Synthesis for Digital Acoustofluidic Biochips.

Journal Article IEEE transactions on biomedical circuits and systems · October 2020 A digital microfluidic biochip (DMB) is an attractive platform for automating laboratory procedures in microbiology. To overcome the problem of cross-contamination due to fouling of the electrode surface in traditional DMBs, a contactless liquid-handling b ... Full text Open Access Cite

Fully implantable neural recording and stimulation interfaces: Peripheral nerve interface applications.

Journal Article Journal of neuroscience methods · March 2020 BackgroundPeripheral nerve interfacing has many applications ranging from investigation of neural signals to therapeutic intervention for varied diseases. This need has driven technological advancements in the field of electrode arrays and wireles ... Full text Open Access Cite

Hardware Design and Experimental Demonstrations for Digital Acoustofluidic Biochips

Conference Biocas 2019 Biomedical Circuits and Systems Conference Proceedings · October 1, 2019 A digital microfluidic biochip (DMB) is an attractive platform for automating laboratory procedures in microbiology. To overcome the problem of cross-contamination due to fouling of the electrode surface in traditional DMBs, a contactless liquid-handling b ... Full text Cite

16-Channel biphasic current-mode programmable charge balanced neural stimulation.

Journal Article Biomedical engineering online · August 2017 BackgroundNeural stimulation is an important method used to activate or inhibit action potentials of the neuronal anatomical targets found in the brain, central nerve and peripheral nerve. The neural stimulator system produces biphasic pulses that ... Full text Open Access Cite

A wirelessly controlled implantable LED system for deep brain optogenetic stimulation.

Journal Article Frontiers in integrative neuroscience · January 2015 In recent years optogenetics has rapidly become an essential technique in neuroscience. Its temporal and spatial specificity, combined with efficacy in manipulating neuronal activity, are especially useful in studying the behavior of awake behaving animals ... Full text Open Access Cite

A wireless multi-channel recording system for freely behaving mice and rats.

Journal Article PloS one · January 2011 To understand the neural basis of behavior, it is necessary to record brain activity in freely moving animals. Advances in implantable multi-electrode array technology have enabled researchers to record the activity of neuronal ensembles from multiple brai ... Full text Open Access Cite

Wireless headstage for neural prosthetics

Conference 2nd International IEEE EMBS Conference on Neural Engineering · December 1, 2005 The continuous monitoring of electrical brain activity with implanted electrodes is essential for understanding the neural substrates of many physiological and pathological brain functions. Although this is done in some patients before undergoing surgical ... Full text Cite

Enhanced phase noise modeling of fractional-N frequency synthesizers

Journal Article IEEE Transactions on Circuits and Systems I Regular Papers · January 1, 2005 Mathematical models for the behavior of fractional-N phase-locked-loop frequency synthesizers (Frac-N) are presented. The models are intended for calculating rms phase error and determining spurs in the output of Frac-N. The models describe noise contribut ... Full text Cite

Novel frame buffer pixel circuits for liquid-crystal-on-silicon microdisplays

Journal Article IEEE Journal of Solid State Circuits · January 1, 2004 A 32 × 16 liquid-crystal-on-silicon (LCDS) backplane with novel frame buffer pixels is designed and fabricated using the AMI Semiconductor's 0.5-μm double-poly triple-metal CMOS process. The three novel pixel circuits described herein increase the brightne ... Full text Cite

Two multichannel integrated circuits for neural recording and signal processing.

Journal Article IEEE Trans Biomed Eng · February 2003 We have developed, manufactured, and tested two analog CMOS integrated circuit "neurochips" for recording from arrays of densely packed neural electrodes. Device A is a 16-channel buffer consisting of parallel noninverting amplifiers with a gain of 2 V/V. ... Full text Link to item Cite

A LCOS microdisplay driver with frame buffer pixels

Journal Article Information Sciences · January 1, 2003 A liquid crystal on silicon (LCOS) microdisplay driver with frame buffer pixels was discussed. LCOS was fabricated for projection display using AMI 0.5 μm double-poly, triple-level metal CMOS process. It was found that the driver includes frame buffering a ... Full text Cite

Optimization of frame buffer pixels for an LCOS microdisplay

Conference PROCEEDINGS OF THE 7TH JOINT CONFERENCE ON INFORMATION SCIENCES · 2003 Cite

64-Channel ultrasound transducer amplifier

Conference 2003 Southwest Symposium on Mixed Signal Design Ssmsd 2003 · January 1, 2003 In this paper we present a 64-channel ultrasound preamplifier device that is used to amplify and filter pulsed echo transducer signals sourced from a real time three dimensional (RT3DU) non-invasive ultrasound system. Schematics, simulation data, and layou ... Full text Cite

16-channel neural pre-conditioning device

Conference International IEEE EMBS Conference on Neural Engineering Ner · January 1, 2003 We present the mixed-signal circuit design, layout, implementation techniques, and test data for a 16-channel neural pre-conditioning device that is used to amplify and filter signals acquired from chronically implanted electrodes in an animal's brain. Sch ... Full text Cite

A multichannel CMOS analog front end IC for neural recordings

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology Proceedings · December 1, 2002 A multichannel integrated circuit for processing extracellular neural signals has been designed and manufactured. The analog CMOS IC consists of 17 parallel channels, each comprised of three cascaded stages: bandpass filter with gain, switched capacitor fi ... Cite

A LCOS Microdisplay Driver with Frame Buffering Pixels

Conference Proceedings of the Joint Conference on Information Sciences · December 1, 2002 An 8-bit LCOS microdisplay driver for projection display has been designed and fabricated using AMI 0.5 um double-poly, triple-level metal CMOS process. The driver includes frame buffering at the pixel level, which presents optimized optical characteristic ... Cite

14-bit 2.2-MS/s sigma-delta ADC's

Journal Article IEEE Journal of Solid State Circuits · July 1, 2000 This paper presents the design and test results of a fourth-order and sixth-order 14-bit 2.2-MS/s sigma-delta analog-to-digital converter (ADC). The analog modulator and digital decimator sections were implemented in a 0.35-mm CMOS double-poly triple-level ... Full text Cite

Designing a brain- machine interface for neuroprosthetic control

Chapter · January 1, 2000 There are roughly four major subassemblies of a brain derived neuroprosthetic control device: (1) the electrodes subassembly, (2) signal conditioning subassembly, (3) signal acquisition subassembly, and (4) transmitter subassemblies (Table 6.1). Notably ab ... Cite

SNDR sensitivity analysis for cascaded ΣΔ modulators

Conference Proceedings IEEE International Symposium on Circuits and Systems · January 1, 2000 Cascade, single and multi-bit, ΣΔ architectures provide stable, high order quantization noise shaping used in high resolution A/D conversion. One major disadvantage of cascaded ΣΔ topologies is the extreme SNDR sensitivity to gain mismatch between the anal ... Full text Cite

14-bit, 2.2MS/s sigma delta ADCs

Conference European Solid State Circuits Conference · December 1, 1999 This paper presents the design and test results of a 4th and 6th order, 14-bit, 2.2MS/s sigma-delta ADC. The analog modulator and digital decimator sections were implemented in a.35μM CMOS, double poly, triple level metal 3.3v process. The design objective ... Cite