Scholars@Duke
Joseph W Turek

Joseph W Turek

Associate Professor of Surgery
Surgery, Cardiovascular and Thoracic Surgery
joseph.turek@duke.edu
DUMC3474, Durham, NC 27710
2301 Erwin Road, DUMC 3474, Durham, NC 27710

Selected Publications

Early single-center experience with an ex vivo organ care system in pediatric heart transplantation.

Journal Article J Heart Lung Transplant · April 2025 Pediatric heart transplantation (HTx) faces challenges such as limited donor availability and the need for complex reconstructions, particularly in patients with congenital anomalies. Ex vivo perfusion offers a promising approach to minimize graft ischemic ... Full text Link to item Cite

Partial Heart Transplant Update: Where Are We In 2025?

Journal Article Semin Thorac Cardiovasc Surg · March 19, 2025 Partial heart transplantation (PHT) creates a new and innovative approach to allow for patient and disease tailored intervention with the ability to treat a larger patient base. It offers the growth capacity of a heart transplantation without the need for ... Full text Link to item Cite

Global cardiothoracic surgery: outcomes from a survey on current worldwide training programmes

Journal Article Interdisciplinary Cardiovascular and Thoracic Surgery · March 1, 2025 OBJECTIVES: There are significant disparities in global access to cardiothoracic surgery. Training a diverse cohort of global cardiothoracic surgeons is a critical step. However, little is known about training pathways globally, and there is a lack of stan ... Full text Cite

Xenotransplant Equipoise: Heisenberg Would be Proud

Journal Article Annals of Surgery · February 1, 2025 Full text Cite

How I Do It: Donation After Circulatory Death With Normothermic Regional Perfusion in Small Babies

Journal Article Operative Techniques in Thoracic and Cardiovascular Surgery · January 1, 2025 Background: The gold standard for treatment of patients with end-stage heart failure remains heart transplantation. Time spent on the active waiting list, notably for pediatric patients, contributes to alarmingly high mortality. Donation after circulatory ... Full text Cite

Review of Current Normothermic Regional Perfusion Practice in Pediatric Cardiac Donation.

Journal Article Ann Thorac Surg · December 16, 2024 BACKGROUND: Cardiac allotransplantation is the optimal treatment for end-stage heart failure. However, organ supply remains the principal issue affecting patients. Pediatric patients present unique challenges resulting in long wait-list times and increased ... Full text Link to item Cite

Aberrant right subclavian artery intervention can provide relief of dysphagia.

Journal Article Cardiol Young · December 2024 BACKGROUND: An aberrant right subclavian artery represents the most common aortic arch vascular anomaly. Conventional wisdom states that these anomalies do not result in dysphagia, but rather serve as "red herrings". Clearly, in the vast majority of cases, ... Full text Link to item Cite

Novel linkage of the Society of Thoracic Surgeons database and hospital electronic health records.

Journal Article Cardiol Young · December 2024 BACKGROUND: Society of Thoracic Surgeons Congenital Heart Surgery Database is the largest congenital heart surgery database worldwide but does not provide information beyond primary episode of care. Linkage to hospital electronic health records would captu ... Full text Link to item Cite

Early Outcomes for Management of Atrioventricular Septal Defect-Tetralogy of Fallot in the Last Decade: A Congenital Heart Surgeons' Society Study.

Journal Article World journal for pediatric & congenital heart surgery · November 2024 BackgroundWe sought to determine the management and early outcomes of complete atrioventricular septal defect-tetralogy of Fallot (AVSD-TOF) for a contemporary multicenter cohort.MethodsOf 739 participants in the Congenital Heart Surgeons ... Full text Cite

Surgical Protocol for Partial Heart Transplantation in Growing Piglets.

Journal Article World J Pediatr Congenit Heart Surg · September 2024 Partial heart transplantation is a new approach to deliver growing heart valve implants. Partial heart transplants differ from heart transplants because only the part of the heart containing the necessary heart valve is transplanted. This allows partial he ... Full text Link to item Cite

The Society of Thoracic Surgeons Clinical Practice Guidelines on the Management of Neonates and Infants With Coarctation.

Journal Article Ann Thorac Surg · September 2024 BACKGROUND: Although coarctation of the aorta without concomitant intracardiac pathology is relatively common, there is lack of guidance regarding aspects of its management in neonates and infants. METHODS: A panel of experienced congenital cardiac surgeon ... Full text Link to item Cite

Days alive and out of hospital for children born with single-ventricle heart disease.

Journal Article Cardiol Young · July 2024 BACKGROUND: This study describes the illness burden in the first year of life for children with single-ventricle heart disease, using the metric of days alive and out of hospital to characterize morbidity and mortality. METHODS: This is a retrospective sin ... Full text Link to item Cite

Comprehensive Flow Cytometric, Immunohistologic, and Molecular Assessment of Thymus Function in Rhesus Macaques.

Journal Article Immunohorizons · July 1, 2024 The critical importance of the thymus for generating new naive T cells that protect against novel infections and are tolerant to self-antigens has led to a recent revival of interest in monitoring thymic function in species other than humans and mice. Nonh ... Full text Link to item Cite

The future of partial heart transplantation.

Journal Article The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · June 2024 Heart valve replacement in children is an unsolved problem in congenital cardiac surgery because state-of-the-art heart valve implants do not grow. This leads to serial repeat operations to replace outgrown heart valve implants. Partial heart transplantati ... Full text Cite

The impact of heart valve and partial heart transplant models on the development of banking methods for tissues and organs: A concise review.

Journal Article Cryobiology · June 2024 Cryopreserved human heart valves fill a crucial role in the treatment for congenital cardiac anomalies, since the use of alternative mechanical and xenogeneic tissue valves have historically been limited in babies. Heart valve models have been used since 1 ... Full text Link to item Cite

Textbook Outcome for Superior Cavopulmonary Connection: A Metric for Single Ventricle Heart Surgery.

Journal Article World J Pediatr Congenit Heart Surg · May 2024 Background: To develop a more holistic measure of congenital heart center performance beyond mortality, we created a composite "textbook outcome" (TO) for the Glenn operation. We hypothesized that meeting TO would have a positive prognostic and financial i ... Full text Link to item Cite

Semilunar valve growth and function 10 years after infant heart transplantation: Predicting long-term outcomes of partial heart transplants.

Journal Article Pediatr Transplant · May 2024 INTRODUCTION: Partial heart transplants are a new type of pediatric transplant that replace defective heart valves with the parts of matched donor hearts containing the necessary valves. Short-term outcomes of partial heart transplants are excellent, but l ... Full text Link to item Cite

Survival after partial heart transplantation in a piglet model.

Journal Article Scientific reports · May 2024 Partial heart transplantation (PHT) is a novel surgical approach that involves transplantation of only the part of the heart containing a valve. The rationale for this approach is to deliver growing heart valve implants that reduce the need for future re-o ... Full text Cite

Staged repair of borderline hypoplastic heart disease with early biventricular conversion.

Conference JTCVS Tech · April 2024 OBJECTIVE: In select patients with borderline ventricular hypoplasia, we adopted a strategy of initial single-ventricle palliation followed by staged or direct biventricular conversion by 2 years of age. METHODS: Between 2018 and 2023, 14 newborns with bor ... Full text Link to item Cite

How I Do the Norwood Operation

Journal Article Operative Techniques in Thoracic and Cardiovascular Surgery · March 1, 2024 The Norwood procedure can be performed with several variations including a sustained total all-region (STAR) perfusion technique, introduced at our institution 5 years ago and well described in a prior Operative Techniques article. Regardless of technique ... Full text Cite

Partial Heart Transplant in a Neonate With Irreparable Truncal Valve Dysfunction.

Journal Article JAMA · January 2024 ImportanceThe treatment of neonates with irreparable heart valve dysfunction remains an unsolved problem because there are no heart valve implants that grow. Therefore, neonates with heart valve implants are committed to recurrent implant exchange ... Full text Cite

Partial Heart Transplantation - How to Change the System.

Journal Article Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu · 2024 Partial heart transplantation is the first clinically successful approach to deliver growing heart valve implants. To date, 13 clinical partial heart transplants have been performed. However, turning partial heart transplantation into a routine procedure t ... Full text Link to item Cite

In Memoriam-Dr. Juan León-Wyss (10 January, 1963-18 January, 2024)

Journal Article Cardiology in the Young · January 1, 2024 Full text Cite

Hybrid palliation versus nonhybrid management for a multi-institutional cohort of infants with critical left heart obstruction.

Journal Article J Thorac Cardiovasc Surg · November 2023 OBJECTIVE: To compare patient characteristics and overall survival for infants with critical left heart obstruction after hybrid palliation (bilateral pulmonary artery banding with or without ductal stenting) versus nonhybrid management (eg, Norwood, prima ... Full text Link to item Cite

Repeat pediatric heart transplantation: A united network for organ sharing database analysis.

Journal Article Clin Transplant · November 2023 BACKGROUND: A history of congenital heart disease and previous transplantation are each independently associated with worse survival following pediatric heart transplantation. This study aimed to evaluate the characteristics and outcomes of children underg ... Full text Link to item Cite

Improving Outcomes for Infants After Cardiopulmonary Bypass Surgery for Congenital Heart Disease: A Commentary on Recent Randomized Controlled Trials.

Journal Article Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · November 2023 Full text Cite

Hybrid approach to pulmonary vein stenting after Fontan palliation.

Journal Article Catheter Cardiovasc Interv · November 2023 Pulmonary vein stenosis is poorly tolerated in patients who have undergone Fontan palliation and typically requires surgical or transcatheter intervention. Percutaneous transcatheter approaches to intervention can be technically difficult due to challengin ... Full text Link to item Cite

Outcomes After Hybrid Palliation for Infants With Critical Left Heart Obstruction.

Journal Article Journal of the American College of Cardiology · October 2023 BackgroundHybrid palliation (bilateral pulmonary artery banding with or without ductal stenting) is an initial management strategy for infants with critical left heart obstruction and serves as palliation until subsequent operations are pursued. Full text Cite

Use of microaxial flow pumps in adolescents.

Journal Article JTCVS Tech · October 2023 OBJECTIVES: The Impella 5.5 has been successfully used in the adult population; however, safety and efficacy data in patients aged less than 18 years are limited. METHODS: Six pediatric patients, aged 13 to 16 years and weighing 45 to 113 kg, underwent axi ... Full text Link to item Cite

Predictors of increased postoperative length of stay after complete atrioventricular canal repair.

Journal Article Cardiol Young · September 2023 BACKGROUND: The optimal timing of surgical repair for infants with complete atrioventricular canal defect remains controversial, as there are risks to both early and late repair. We address this debate by investigating the association of various risk facto ... Full text Link to item Cite

Impact of Ventricular Dominance on Long-Term Fontan Outcomes: A 25-year Single-institution Study.

Journal Article Ann Thorac Surg · September 2023 BACKGROUND: The long-term impact of ventricular dominance on Fontan outcomes is controversial. This study examined this issue in a 25-year cohort. METHODS: Patients undergoing the Fontan operation at a single institution (Duke University Medical Center, Du ... Full text Link to item Cite

Norwood operation versus comprehensive stage II after bilateral pulmonary artery banding palliation for infants with critical left heart obstruction.

Journal Article J Thorac Cardiovasc Surg · September 2023 OBJECTIVE: To determine patient characteristics and outcomes after Norwood versus comprehensive stage II (COMPSII) for infants with critical left heart obstruction who had prior hybrid palliation (bilateral pulmonary artery banding ± ductal stent). METHODS ... Full text Link to item Cite

Textbook outcome for the Norwood operation-an informative quality metric in congenital heart surgery.

Journal Article JTCVS Open · September 2023 OBJECTIVES: To develop a more holistic measure of center performance than operative mortality, we created a composite "textbook outcome" for the Norwood operation using several postoperative end points. We hypothesized that achieving the textbook outcome w ... Full text Link to item Cite

Understanding and Managing Direct Operating Room Supply Costs in Cardiac Surgery.

Journal Article Ann Thorac Surg · June 2023 BACKGROUND: Value-based bundles require surgeons to understand their costs. Current approaches to cost reporting are confusing and difficult to reproduce. Using the Epic surgical receipt function, we describe an intuitive and systematic approach for evalua ... Full text Link to item Cite

Outcomes of truncal valve replacement in neonates and infants: a meta-analysis.

Journal Article Cardiol Young · May 2023 BACKGROUND: Infants with truncus arteriosus typically undergo repair by repurposing the truncal valve as the neo-aortic valve and using a valved conduit homograft for the neo-pulmonary valve. In cases where the native truncal valve is too insufficient for ... Full text Link to item Cite

Single stage biventricular repair of hypoplastic right ventricle with straddling tricuspid valve.

Journal Article Cardiol Young · April 2023 We present the case of a five-year-old child with an inlet ventricular septal defect, subpulmonic stenosis, hypoplastic right ventricle, and straddling tricuspid valve who received a successful one-stage biventricular repair with right ventricular rehabili ... Full text Link to item Cite

Growing Heart Valve Implants for Children.

Journal Article J Cardiovasc Dev Dis · March 31, 2023 The current standard of care for pediatric patients with unrepairable congenital valvular disease is a heart valve implant. However, current heart valve implants are unable to accommodate the somatic growth of the recipient, preventing long-term clinical s ... Full text Link to item Cite

Comparison of median sternotomy and left anterior mini-incision for pulmonary valve replacement following primary tetralogy of Fallot repair.

Journal Article Cardiol Young · January 2023 OBJECTIVE: Pulmonary insufficiency requiring reintervention frequently occurs after primary tetralogy of Fallot repair. Repeat interventions present a challenge for both the surgeon and patient. We compare a minimally invasive, 5 cm left anterior mini-inci ... Full text Link to item Cite

Sustained Total All-Region Perfusion During the Norwood Operation and Postoperative Recovery.

Journal Article Semin Thorac Cardiovasc Surg · 2023 We developed a technique for the Norwood operation utilizing continuous perfusion of the head, heart, and lower body at mild hypothermia named Sustained Total All-Region (STAR) perfusion. We hypothesized that STAR perfusion would be associated with shorter ... Full text Link to item Cite

Whole-Chest Three-Dimensional Modeling Aids Hybrid Pulmonary Valve Replacement Following Double Switch Operation.

Journal Article World J Pediatr Congenit Heart Surg · January 2023 The double switch operation for congenitally corrected transposition of the great arteries (CC-TGA) has been associated with high rates of reintervention, including the need for pulmonary valve replacement. Hybrid interventional approaches can avoid bypass ... Full text Link to item Cite

Partial heart transplantation for pediatric heart valve dysfunction: A clinical trial protocol.

Journal Article PLoS One · 2023 Congenital heart defects are the most common type of birth defects in humans and frequently involve heart valve dysfunction. The current treatment for unrepairable heart valves involves valve replacement with an implant, Ross pulmonary autotransplantation, ... Full text Link to item Cite

Partial Heart Transplantation in Adult Cardiac Surgery.

Journal Article Innovations (Phila) · 2023 Many young adults require heart valve replacements. Current options for valve replacement in adults include mechanical valves, bioprosthetic valves, or the Ross procedure. Of these, mechanical and bioprosthetic valves are the most common options, although ... Full text Link to item Cite

Management of Pediatric Cardiopulmonary Bypass

Chapter · January 1, 2023 The development of cardiopulmonary bypass (CPB) and the modern era of open-heart surgery arose from early attempts to correct intracardiac congenital heart defects in children using extracorporeal circulation. This chapter explains that the safe performanc ... Full text Cite

Methylprednisolone for Heart Surgery in Infants - A Randomized, Controlled Trial.

Journal Article N Engl J Med · December 8, 2022 BACKGROUND: Although perioperative prophylactic glucocorticoids have been used for decades, whether they improve outcomes in infants after heart surgery with cardiopulmonary bypass is unknown. METHODS: We conducted a multicenter, prospective, randomized, p ... Full text Link to item Cite

Allergic response to medical products in patients with alpha-gal syndrome.

Journal Article J Thorac Cardiovasc Surg · December 2022 BACKGROUND: Galactose-α-1,3-galactose (alpha-gal) is a carbohydrate that is ubiquitously expressed in all mammals except for primates and humans. Patients can become sensitized to this antigen and develop alpha-gal syndrome (AGS), or a red meat allergy. Sy ... Full text Link to item Cite

Toward improved understanding of cardiac development and congenital heart disease: The advent of cardiac organoids.

Journal Article J Thorac Cardiovasc Surg · December 2022 Human cardiac organoid systems hold significant promise for mechanistic studies of early heart morphogenesis and an improved understanding of congenital cardiac disease. ... Full text Link to item Cite

Survival After Intervention for Single-Ventricle Heart Disease Over 15 Years at a Single Institution.

Journal Article Ann Thorac Surg · December 2022 BACKGROUND: Children with single-ventricle (SV) heart disease possess a spectrum of heart malformations, yet progress through similar hemodynamic states, suggesting differences in outcomes are related to fundamental morphologic differences, patient charact ... Full text Link to item Cite

Partial heart transplantation can ameliorate donor organ utilization.

Journal Article J Card Surg · December 2022 BACKGROUND: The treatment of babies with unrepairable heart valve dysfunction remains an unsolved problem because there are no growing heart valve implants. However, orthotopic heart transplants are known to grow with recipients. AIM: Partial heart transpl ... Full text Link to item Cite

Biventricular Conversion of Borderline Hypoplastic Left Heart Complex Facilitated by Spontaneous Closure of the Atrial Septum.

Journal Article World J Pediatr Congenit Heart Surg · September 2022 We present the case of a child with borderline hypoplastic left heart complex who initially received Norwood and Glenn operations without atrial septectomy and was later converted to a biventricular circulation after progressive growth of the left ventricl ... Full text Link to item Cite

Introducing thymus for promoting transplantation tolerance.

Journal Article J Allergy Clin Immunol · September 2022 Establishing tolerance remains a central, if elusive, goal of transplantation. In solid-organ transplantation, one strategy for inducing tolerance has been cotransplantation of various forms of thymic tissue along with another organ. As one of the biologic ... Full text Link to item Cite

Recent advances in porcine cardiac xenotransplantation: from aortic valve replacement to heart transplantation.

Journal Article Expert Rev Cardiovasc Ther · August 2022 INTRODUCTION: Cardiac xenotransplantation presents significant potential to the field of heart failure by addressing the high demand for donor organs. The availability of xenograft hearts would substantially augment the number of life-saving organs availab ... Full text Link to item Cite

Early Outcomes of Patients Undergoing Neoaortic Valve Repair Incorporating Geometric Ring Annuloplasty.

Journal Article World J Pediatr Congenit Heart Surg · May 2022 OBJECTIVES: During congenital heart surgery, the pulmonary valve and root may be placed into the systemic position, yielding a "neoaortic" valve. With the stress of systemic pressure, the pulmonary roots can dilate, creating aneurysms and/or neoaortic insu ... Full text Link to item Cite

Association of atrial septal fenestration with outcomes after atrioventricular septal defect repair.

Conference J Thorac Cardiovasc Surg · March 2022 OBJECTIVE: During repair of atrioventricular septal defect (AVSD), surgeons might leave an atrial level shunt when concerned about postoperative physiology, or as part of routine practice. However, the association of fenestration with outcomes is unclear. ... Full text Link to item Cite

Minimally Invasive Approach for Cardiac Hemangioma Resection in a Teenager.

Journal Article Innovations (Phila) · 2022 Cardiac hemangiomas are a rare tumor traditionally resected by median sternotomy. We performed a minimally invasive right ventricular cardiac hemangioma resection via a left anterior mini-incision (LAMI). The procedure was without complication, and the pat ... Full text Link to item Cite

Flow Monitoring of ECMO Circuit for Detecting Oxygenator Obstructions.

Journal Article Annals of biomedical engineering · December 2021 Oxygenator thrombosis during extracorporeal membrane oxygenation (ECMO), is a complication that necessitates component replacement. ECMO centers monitor clot burden by intermittent measurement of pressure drop across the oxygenator. An increase in pressure ... Full text Cite

Commentary: Get in the Groove When Stuck Doing the Switch

Journal Article Operative Techniques in Thoracic and Cardiovascular Surgery · December 1, 2021 Full text Cite

Complex Repair of a Completely Fused Nullicuspid Aortic Valve Late in Adolescence.

Journal Article World J Pediatr Congenit Heart Surg · November 2021 We report a case of an 18-year-old female who presented with severe aortic stenosis and insufficiency, eight years following resection of a subaortic membrane. On echocardiography, she was found to have a completely fused or nullicuspid valve, with three e ... Full text Link to item Cite

A single center experience with minimally invasive approaches in congenital cardiac surgery.

Journal Article J Thorac Dis · October 2021 BACKGROUND: Cardiac surgery is a technically demanding field with an appreciable learning curve that extends beyond formal training. Minimally invasive congenital cardiac surgery has one of the steepest learning curves. Early complications often discourage ... Full text Link to item Cite

The Evolving Surgical Burden of Fontan Failure: An Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database

Conference Annals of Thoracic Surgery · July 1, 2021 Background: Fontan failure often requires surgical therapy in the form of Fontan revision or heart transplantation. We sought to characterize national trends in the surgical burden of Fontan failure and identify risk factors for adverse outcomes. Methods: ... Full text Cite

The Evolving Surgical Burden of Fontan Failure: An Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal Article Ann Thorac Surg · July 2021 BACKGROUND: Fontan failure often requires surgical therapy in the form of Fontan revision or heart transplantation. We sought to characterize national trends in the surgical burden of Fontan failure and identify risk factors for adverse outcomes. METHODS: ... Full text Link to item Cite

Sustained Total All-Region (STAR) perfusion for Norwood reconstruction with complex intracardiac repair.

Journal Article Perfusion · July 2021 We present the case of a newborn with complex congenital heart disease who was treated with a neonatal Norwood operation and total anomalous pulmonary venous return repair. During the Norwood reconstruction, a novel technique was utilized to perfuse the he ... Full text Link to item Cite

Transition to Ductal Stenting for Single Ventricle Patients Led to Improved Survival: An Institutional Case Series.

Journal Article World J Pediatr Congenit Heart Surg · July 2021 BACKGROUND: The use of systemic-to-pulmonary shunts (SPS) in neonates with single ventricle heart defects and ductal-dependent pulmonary blood flow (ddPBF) was historically associated with high morbidity and mortality at our center. As a result, we transit ... Full text Link to item Cite

Aortic Valve Repair Using Geometric Ring Annuloplasty

Journal Article Operative Techniques in Thoracic and Cardiovascular Surgery · June 1, 2021 Reparative operations for insufficient cardiac valves constitute the surgical procedures of choice when pathoanatomies permit. At present, mitral and tricuspid repair techniques are well-established, but recent data also suggest that reconstruction of insu ... Full text Cite

Unicuspid Aortic Valve Repair Using Geometric Ring Annuloplasty.

Journal Article Ann Thorac Surg · April 2021 BACKGROUND: Unicuspid aortic valves (Sievers type 2 bicuspid) are characterized by major fusion and clefting of the right-left coronary commissure, and minor fusion of the right-noncoronary commissure. Repair has been difficult because of two fusions, vari ... Full text Link to item Cite

Anomalous Aortic Origin of a Coronary Artery Repair Through an Anterior Minithoracotomy.

Journal Article Innovations (Phila) · 2021 OBJECTIVE: The benefits of minimally invasive adult cardiac surgery are well established. Nevertheless, minimally invasive congenital cardiac procedures, even for adult patients, are uncommon. In 2018, we started repairing anomalous aortic origin of a coro ... Full text Link to item Cite

Implantation of a HeartMate 3 ventricular assist device in a 21-kg pediatric patient with Fontan failure.

Journal Article J Card Surg · December 2020 AIMS: The HeartMate 3 (HM3) ventricular assist device (VAD) is gaining popularity in adults due to a favorable risk profile. However, reports of HM3 use in children are limited, potentially due to concerns with device size. MATERIALS AND METHODS: Here we r ... Full text Link to item Cite

Mustard Baffle Revision With Systemic Ventricular Assist Device Placement.

Journal Article Ann Thorac Surg · October 2020 Systemic right ventricle failure often develops in patients with dextro-transposition of the great arteries who have undergone atrial-level switch procedures. An adult with dextro-transposition of the great arteries with Mustard repair in childhood present ... Full text Link to item Cite

Sustained Total All-Region (STAR) Perfusion for Norwood Reconstruction

Journal Article Operative Techniques in Thoracic and Cardiovascular Surgery · September 1, 2020 The acute phase of recovery following the Norwood procedure can be complicated by considerable instability due in part to bleeding, acute kidney injury, systemic inflammatory response, and low cardiac function. The traditional conduct of cardiopulmonary by ... Full text Cite

Commentary: Right ventricle, right time.

Journal Article JTCVS Tech · September 2020 Full text Link to item Cite

Biventricular Conversion in the Borderline Hypoplastic Heart.

Journal Article Curr Cardiol Rep · August 8, 2020 PURPOSE OF REVIEW: The development of biventricular repair and conversion pathways for patients with borderline hypoplastic heart disease represents an area of recent inquiry and innovation. This review summarizes emerging techniques and novel treatment al ... Full text Link to item Cite

Overcoming underpowering: Trial simulations and a global rank end point to optimize clinical trials in children with heart disease.

Journal Article Am Heart J · August 2020 BACKGROUND: Randomized controlled trials (RCTs) in children with heart disease are challenging and therefore infrequently performed. We sought to improve feasibility of perioperative RCTs for this patient cohort using data from a large, multicenter clinica ... Full text Link to item Cite

Cultured thymus tissue implantation promotes donor-specific tolerance to allogeneic heart transplants.

Journal Article JCI Insight · June 4, 2020 Eighty-six infants born without a thymus have been treated with allogeneic cultured thymus tissue implantation (CTTI). These infants, who lack T cells and are profoundly immunodeficient at birth, after CTTI from an unmatched donor develop T cells similar t ... Full text Open Access Link to item Cite

Aortic valve repair with a newly approved geometric annuloplasty ring in patients undergoing proximal aortic repair: early results from a single-centre experience.

Journal Article Eur J Cardiothorac Surg · June 1, 2020 OBJECTIVES: Aortic insufficiency (AI) is common in patients with proximal aortic disease, but limited options exist to facilitate aortic valve repair (AVr) in this population. This study reports 'real-world' early results of AVr using newly FDA-approved tr ... Full text Link to item Cite

Significance of clamping distance in bovine and normal aortic arch patients

Journal Article Progress in Pediatric Cardiology · June 1, 2020 Bovine aortic arch is an anatomical variant in which the innominate and left common carotid arteries share a common origin. Coarctation of the aorta is a congenital heart defect characterized by narrowing of the aortic arch. Resection with extended end-to- ... Full text Cite

Accelerated Marfan syndrome model recapitulates established signaling pathways.

Journal Article J Thorac Cardiovasc Surg · May 2020 OBJECTIVE: Marfan syndrome (MFS) represents a genetic disorder with a range of clinical features, including proximal aortic aneurysms. Extensive research has revealed an abundance of transforming growth factor beta from a mutation in fibrillin-1 to be the ... Full text Link to item Cite

Commentary: Malacia got you down? Unwind with a helical stent.

Journal Article J Thorac Cardiovasc Surg · May 1, 2020 Full text Link to item Cite

Right Anterior Mini-Incision Approach to Anomalous Right Coronary Artery Repair.

Journal Article World J Pediatr Congenit Heart Surg · March 2020 The right anterior mini-incision has emerged as an effective minimally invasive approach for adult aortic root and valve operations. However, adoption of minimally invasive techniques has been limited in congenital heart surgery. We report a case of anomal ... Full text Link to item Cite

Borrowing from Adult Cardiac Surgeons-Bringing Congenital Heart Surgery Up to Speed in the Minimally Invasive Era.

Journal Article Innovations (Philadelphia, Pa.) · March 2020 The majority of congenital and adult cardiac surgery is performed through a median sternotomy. For surgeons, this incision provides excellent exposure; however, for patients, a median sternotomy confers a poorer cosmetic outcome and the possibility of post ... Full text Open Access Cite

Hybrid transcatheter pulmonary valve replacement with a SAPIEN S3 valve after pulmonary artery banding via left lateral thoracotomy.

Journal Article Catheter Cardiovasc Interv · February 15, 2020 For many patients with repaired congenital heart disease, the need for reintervention on dysfunctional right ventricular outflow tracts is pervasive. Many such patients are poor candidates for both transcatheter pulmonary valve replacement and cardiopulmon ... Full text Link to item Cite

Proteomic Analysis of Infants Undergoing Cardiopulmonary Bypass Using Contemporary Ontological Tools.

Journal Article J Surg Res · February 2020 BACKGROUND: Cardiopulmonary bypass (CPB) is essential for the repair of many congenital cardiac defects in infants but is associated with significant derangements in hemostasis and systemic inflammation. As a result, hemorrhagic complications and thrombosi ... Full text Link to item Cite

Rationale and design of the STeroids to REduce Systemic inflammation after infant heart Surgery (STRESS) trial.

Journal Article Am Heart J · February 2020 For decades, physicians have administered corticosteroids in the perioperative period to infants undergoing heart surgery with cardiopulmonary bypass (CPB) to reduce the postoperative systemic inflammatory response to CPB. Some question this practice becau ... Full text Link to item Cite

Association between preoperative respiratory support and outcomes in paediatric cardiac surgery.

Journal Article Cardiol Young · January 2020 BACKGROUND: Preoperative mechanical ventilation is associated with morbidity and mortality following CHD surgery, but prior studies lack a comprehensive analysis of how preoperative respiratory support mode and timing affects outcomes. METHODS: We retrospe ... Full text Open Access Link to item Cite

Initial Application of a Bicuspid Aortic Annuloplasty Ring in Pediatric Cardiac Surgery.

Journal Article Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu · 2020 Aortic stenosis and aortic insufficiency (AI) are common valvular conditions that may necessitate repair or replacement of the aortic valve. Aortic valve replacement is associated with higher long-term complications and thus, a consistent, reliable method ... Full text Link to item Cite

Left Anterior Mini-Incision for Pulmonary Valve Replacement Following Tetralogy of Fallot Repair.

Journal Article Innovations (Phila) · 2020 Pulmonary insufficiency is a known complication following Tetralogy of Fallot repair. With over 90% of patients now surviving to adulthood, surgeons are once again faced with the question of when, and more importantly, how to reintervene. We developed a no ... Full text Open Access Link to item Cite

Left Anterior Mini-Incision for Pulmonary Valve Replacement in a 12-Year-Old.

Journal Article Innovations (Phila) · 2020 A 12-year-old, 32 kg male with history of Tetralogy of Fallot status post repair at 8 days of life presented with progressive pulmonary insufficiency and left pulmonary artery stenosis. Surgical options were discussed, and the patient and his family electe ... Full text Open Access Link to item Cite

Insights into Arch Vessel Development in the Bovine Aortic Arch.

Journal Article Pediatr Cardiol · October 2019 A bovine arch is the most common aortic arch variant, characterized by a common origin of the innominate artery and the left common carotid artery. Data have shown that children with bovine arch anatomy and coarctation are at a significantly higher risk of ... Full text Link to item Cite

Coronary artery arteriovenous malformation.

Journal Article J Thorac Cardiovasc Surg · April 2019 Full text Link to item Cite

Recent Advances in Congenital Heart Surgery: Alternative Perfusion Strategies for Infant Aortic Arch Repair.

Journal Article Curr Cardiol Rep · February 28, 2019 PURPOSE OF REVIEW: This paper will discuss current cannulation strategies for infant aortic arch repair and compare them to more traditionally used techniques. RECENT FINDINGS: Aortic arch reconstruction in infants has traditionally involved deep hypotherm ... Full text Link to item Cite

Less Is More in Post Pediatric Heart Transplant Care.

Journal Article Ann Thorac Surg · January 2019 BACKGROUND: Historically, steroids and endomyocardial biopsies have, respectively, been part of standard immunosuppression for preventing cardiac transplant rejection and monitoring for rejection. However, these treatments come with numerous adverse effect ... Full text Link to item Cite

Minimally Invasive Pulmonary Fibroelastoma Resection.

Journal Article Innovations (Phila) · 2019 Pulmonary fibroelastomas are a rare primary cardiac tumor with less than 50 cases reported in the literature to date. We performed a minimally invasive valve-sparing tumor resection through a left anterior mini-incision (LAMI). The procedure was performed ... Full text Open Access Link to item Cite

Development of a Pediatric Cardiac Mechanical Support Program.

Journal Article Artif Organs · April 2018 The development of a pediatric cardiac support program is a complex, multidisciplinary project. This study describes the University of Iowa Congenital Heart Program's experience from its inception to the present. In, we examine those specific factors that ... Full text Link to item Cite

Bovine arch anatomy influences recoarctation rates in the era of the extended end-to-end anastomosis.

Journal Article The Journal of thoracic and cardiovascular surgery · March 2018 ObjectivesArch branching has never been shown to influence recoarctation after extended end-to-end anastomosis via thoracotomy, yet in each study bovine arch identification is grossly underreported. This study aims to (1) assess chart review relia ... Full text Cite

Successful Prediction of a Left Nonrecurrent Laryngeal Nerve in a Patient With Right-Sided Aorta and Aberrant Left Subclavian Artery.

Journal Article Ann Otol Rhinol Laryngol · February 2018 BACKGROUND: Left nonrecurrent laryngeal nerve (LNRLN) is an extremely rare anatomic variant. The development of such anatomic variation requires the regression of both the fourth (aortic arch) and sixth (ductus arteriosus, DA) arches on the left side. Preo ... Full text Link to item Cite

Acquired ventricular septal defect due to infective endocarditis.

Journal Article Ann Pediatr Cardiol · 2018 Acquired intracardiac left-to-right shunts are rare occurrences. Chest trauma and myocardial infection are well-known causes of acquired ventricular septal defect (VSD). There have been several case reports describing left ventricle to right atrium shunt a ... Full text Link to item Cite

A Minimally Invasive Approach for Placing Sew-On Epicardial Leads in the Child.

Journal Article Innovations (Phila) · 2018 Traditionally, pacing leads are placed transvenously, although smaller pediatric patients who require permanent pacemakers may benefit from delaying tranvenous lead placement until they are larger. Alternative, minimally invasive atrioventricular pacing op ... Full text Link to item Cite

Mitral valve disease

Chapter · January 1, 2018 Congenital mitral valve disease is rarely seen in isolation. It is more commonly associated with complex congenital defects, including Shone’s complex, hypoplastic left heart syndrome, transposition of the great arteries, and connective tissue diseases. Sy ... Full text Cite

Shifting Risks and Conflicting Outcomes-ECMO for Neonates with Congenital Diaphragmatic Hernia in the Modern Era.

Journal Article J Pediatr · November 2017 OBJECTIVES: To update previously described trends for neonates with congenital diaphragmatic hernia (CDH) receiving ECMO with changes in recommendations for care, and to determine how recent advancements in respiratory care have affected this patient popul ... Full text Link to item Cite

Intraoperative High-Frequency Jet Ventilation Is Equivalent to Conventional Ventilation During Patent Ductus Arteriosus Ligation.

Journal Article World J Pediatr Congenit Heart Surg · September 2017 BACKGROUND: Patent ductus arteriosus (PDA) treatment is typically pharmacologic, but if unsuccessful, surgical ligation is commonly performed. High-frequency jet ventilation (HFJV) is used at the University of Iowa Stead Family Children's Hospital for extr ... Full text Link to item Cite

A Novel Murine Model of Marfan Syndrome Accelerates Aortopathy and Cardiomyopathy.

Conference Ann Thorac Surg · August 2017 BACKGROUND: Marfan syndrome (MFS) represents a genetic disorder with variable phenotypic expression. The main cardiovascular sequelae of MFS include aortic aneurysm/dissection and cardiomyopathy. Although significant advances in the understanding of transf ... Full text Link to item Cite

Modeling Outcomes

Journal Article Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery · March 2017 Full text Cite

Endovascular Treatment of a Traumatic Thoracic Aortic Injury in an Eight-Year Old Patient: Case Report and Review of Literature.

Journal Article Ann Vasc Surg · February 2017 Traumatic aortic injuries in children and adolescents are rare. Although endovascular repair has become the preferred approach for such injuries in adults, open repair has endured as the gold standard in children owing mainly to the smaller aortic and acce ... Full text Link to item Cite

Report of the 2015 Society of Thoracic Surgeons Congenital Heart Surgery Practice Survey.

Conference Ann Thorac Surg · February 2017 BACKGROUND: The Society of Thoracic Surgeons Workforce on Congenital Heart Surgery (CHS) undertook a third subspecialty Practice Survey (2005, 2010, 2015) to obtain contemporary data. METHODS: A search for potential participants was conducted using multipl ... Full text Link to item Cite

Aortic Root Reconstruction with a New Dacron Graft Featuring Prefabricated Coronary Side Branches: Lessons Learned from the Cabrol Procedure.

Journal Article Aorta (Stamford) · February 2017 BACKGROUND: Coronary button reimplantation can represent a technical challenge of aortic root reconstruction that can be associated with significant morbidity and mortality. With the goal of simplifying coronary reimplantation and reducing the incidence of ... Full text Link to item Cite

Modeling Outcomes: Modified Aortic Arch Advancement for Neonatal Hypoplastic Arch.

Journal Article Innovations (Phila) · 2017 OBJECTIVE: Numerous surgical approaches regarding aortic arch advancement for neonatal arch hypoplasia have been described. These repairs can be classified into two categories: those that incorporate a patch and those that do not. The decision between repa ... Full text Link to item Cite

Efficacy of Flow Monitoring During ECMO.

Journal Article ASAIO J · 2017 The hypothesis that blood flow monitoring could serve as an effective early indicator of distal obstruction during extracorporeal membrane oxygenation (ECMO) was tested under controlled experimental conditions. The ECMO circuit typically includes (or could ... Full text Link to item Cite

Assessment of potential confounders when imaging pectus excavatum with chest radiography alone.

Journal Article J Pediatr Surg · September 2016 BACKGROUND: Chest radiography (CXR) has emerged as an attractive alternative imaging option for objective pre-operative assessment of pectus excavatum (PE) with comparable accuracy, reduced cost, and less radiation exposure when compared to computed tomogr ... Full text Link to item Cite

Intervention for Supravalvar Pulmonary Stenosis After the Arterial Switch Operation.

Journal Article Ann Thorac Surg · July 2016 BACKGROUND: The arterial switch operation is standard of care for infants born with dextrotransposition of the great arteries. Supravalvar pulmonary stenosis is a common complication that may require reintervention-balloon angioplasty, stenting, or surgica ... Full text Link to item Cite

Novel Utilization of the Bridge during Weaning off Venoarterial ECMO: The Hoffman Clamp Method

Journal Article Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery · May 2016 Full text Cite

Transventricular approaches to pulmonary valve replacement

Chapter · January 1, 2016 With over 100,000 Americans currently surviving with repaired tetralogy of Fallot and ever-lowering thresholds for pulmonary valve replacement, interventions on the right ventricular outflow tract will continue to drive the practice of reoperative congenit ... Full text Cite

Use of pulmonary arteriovenous extracorporeal membrane oxygenation in conjunction with the total artificial heart.

Journal Article Perfusion · January 2016 The temporary total artificial heart (TAH-t) is approved for destination therapy or bridge to transplant and is associated with improved survival rates before and after transplantation [1]. Postoperatively, patients with the TAH-t may experience acute resp ... Full text Link to item Cite

Novel Utilization of the Bridge During Weaning Off Venoarterial ECMO: The Hoffman Clamp Method.

Journal Article Innovations (Phila) · 2016 Standard practice for weaning patients off venoarterial extracorporeal membrane oxygenation (ECMO) occurs by decreasing pump flows until idle flow is achieved. This method is limited in its use because it is difficult to assess a patient's true potential t ... Full text Link to item Cite

The case for using the correction index obtained from chest radiography for evaluation of pectus excavatum.

Journal Article J Pediatr Surg · November 2015 BACKGROUND: We previously reported the use of a computed tomography (CT)-based Correction Index (CI) as a more accurate assessment of pectus excavatum (PE) severity than the historically used Haller Index (HI). This study examines the diagnostic capabiliti ... Full text Link to item Cite

Beating-Heart Sliding Arch Aortoplasty for Arch Hypoplasia beyond Infancy

Journal Article Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery · November 2015 Full text Cite

A Decade of Change: Training and Career Paths of Cardiothoracic Surgery Residents 2003 to 2014.

Journal Article Ann Thorac Surg · October 2015 BACKGROUND: During the past decade, cardiothoracic surgery (CTS) education has undergone tremendous change with the advent of new technologies and the implementation of integrated programs, to name a few. The goal of this study was to assess how residents' ... Full text Link to item Cite

Use of HeartWare Ventricular Assist System for systemic ventricular support of a pediatric patient after Mustard procedure.

Journal Article World J Pediatr Congenit Heart Surg · April 2015 BACKGROUND: The HeartWare Ventricular Assist System is indicated to provide mechanical circulatory support of patients with intractable heart failure as a bridge to cardiac transplantation. We describe the use of this device to support the systemic right v ... Full text Link to item Cite

A Minimally Invasive, Algorithm-Based Approach for Anomalous Aortic Origin of a Coronary Artery

Journal Article Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery · March 2015 Full text Cite

A minimally invasive, algorithm-based approach for anomalous aortic origin of a coronary artery.

Journal Article Innovations (Phila) · 2015 OBJECTIVE: Operative repair for anomalous aortic origin of a coronary artery (AAOCA) has been described using various innovative techniques. Common to each series is the use of a full sternotomy. As demand for minimally invasive approaches to adult cardiac ... Full text Link to item Cite

Pseudo-preexcitation is prevalent among patients with repaired complex congenital heart disease.

Journal Article Pediatr Cardiol · January 2015 This study aimed to evaluate the prevalence of preexcitation and possible pseudo-preexcitation among patients undergoing complex congenital heart surgery at a single center. During a 6-year period (2007-2013), the study retrospectively reviewed the electro ... Full text Link to item Cite

Beating-Heart Sliding Arch Aortoplasty for Arch Hypoplasia Beyond Infancy.

Journal Article Innovations (Phila) · 2015 Hypoplasia of the aortic arch commonly accompanies coarctation of the aorta and should be addressed at the time of coarctation repair to prevent residual gradient. Using a novel technique, McKenzie et al performed an ascending sliding arch aortoplasty to c ... Full text Link to item Cite

Reply: To PMID 24582050.

Journal Article Ann Thorac Surg · December 2014 Full text Link to item Cite

Exposure of difficult left hilum in bilateral sequential lung transplantation.

Journal Article Ann Thorac Surg · October 2014 Left hilar exposure can be challenging during bilateral sequential lung transplantation, particularly in patients with idiopathic pulmonary fibrosis due to the overlying heart and limited space. We describe a cost-effective technique that has been used in ... Full text Link to item Cite

Mycotic aneurysm in a child with history of coarctation of the aorta repair.

Journal Article Ann Pediatr Cardiol · May 2014 A mycotic aneurysm is a rare condition occasionally seen in patients with a history of prior cardiac or vascular surgery. Here we report the presentation of a mycotic aneurysm in a pediatric patient at the site of prior aortic coarctation repair. This pati ... Full text Link to item Cite

The correction index: setting the standard for recommending operative repair of pectus excavatum.

Journal Article Ann Thorac Surg · April 2014 BACKGROUND: The Haller index, derived from a chest computed tomography scan, remains the standard for determining candidacy for pectus excavatum repair (Haller index≥3.25). However, it has been suggested that this index may not accurately reflect pectus se ... Full text Link to item Cite

Defining the Role of Chest Radiography in Determining Candidacy for Pectus Excavatum Repair

Journal Article Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery · March 2014 Full text Cite

Technique of aortic root reconstruction using a new model of Dacron graft with prefabricated coronary branches.

Journal Article Innovations (Phila) · 2014 Aortic root reconstruction is a demanding surgical procedure still associated with a significant morbidity. Arguably, the most demanding aspect of the operation is reestablishing continuity between the prosthetic graft replacing the aortic root and the cor ... Full text Link to item Cite

Technique of aortic root reconstruction using a new model of dacron graft with prefabricated coronary branches

Journal Article Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery · January 1, 2014 © 2014 by the International Society for Minimally Invasive Cardiothoracic Surgery. Aortic root reconstruction is a demanding surgical procedure still associated with a significant morbidity. Arguably, the most demanding aspect of the operation is reestabli ... Cite

Defining the role of chest radiography in determining candidacy for pectus excavatum repair.

Journal Article Innovations (Phila) · 2014 OBJECTIVE: The Haller index (HI), derived from computed tomography (CT) of the chest, remains the standard for determining pectus excavatum (PE) severity. The ability to accurately determine PE severity from chest radiography (CXR) may provide substantial ... Full text Link to item Cite

Pentalogy of Cantrell with ectopia cordis totalis, total anomalous pulmonary venous connection, and tetralogy of Fallot: a case report and review of the literature.

Journal Article Congenit Heart Dis · 2014 Pentalogy of Cantrell is a rare condition with a varied expression and a high mortality. We present a patient with the classic pentad (type 1), but with a previously undescribed constellation of cardiac manifestations including ectopia cordis totalis, tota ... Full text Link to item Cite

Semiautologous repair for congenital discontinuous right pulmonary artery.

Journal Article Ann Thorac Surg · December 2013 Unilateral absence of a proximal pulmonary artery (UAPA) is rare and occurs in an isolated form or in the presence of other cardiovascular anomalies. There is a paucity of literature describing surgical correction of this anomaly. Most commonly, a primary ... Full text Link to item Cite

Norwood reconstruction using continuous coronary perfusion: a safe and translatable technique.

Journal Article Ann Thorac Surg · July 2013 BACKGROUND: Continuous coronary perfusion during Norwood reconstruction offers the theoretic advantage of less postoperative cardiac dysfunction. The avoidance of a cardiac and circulatory arrest period allows time for a more deliberate aortic reconstructi ... Full text Link to item Cite

Normothermic Cardiopulmonary Bypass with Beating Heart for Management of Renal Cell Carcinoma with Atrial Tumor Thrombus

Journal Article Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery · June 2013 Full text Cite

Outcomes before and after implementation of a pediatric rapid-response extracorporeal membrane oxygenation program.

Journal Article Ann Thorac Surg · June 2013 BACKGROUND: Rapid-response extracorporeal membrane oxygenation (RR-ECMO) has been implemented at select centers to expedite cannulation for patients placed on ECMO during extracorporeal cardiopulmonary resuscitation (ECPR). In 2008, we established such a p ... Full text Link to item Cite

Cardiac manifestations of Q fever infection: case series and a review of the literature.

Journal Article J Card Surg · May 2013 BACKGROUND: Q fever is a zoonotic disease caused by Coxiella burnetii, an uncommon intracellular bacterium found in livestock and domesticated dogs and cats. A minority of patients who acquire acute Q fever will subsequently develop chronic Q fever endocar ... Full text Link to item Cite

Normothermic cardiopulmonary bypass with beating heart for management of renal cell carcinoma with atrial tumor thrombus.

Journal Article Innovations (Phila) · 2013 Renal cell carcinoma is occasionally complicated by the formation of a neoplastic thrombus invading the inferior vena cava. Rarely, the thrombus extends into the vena cava, reaching the right atrium. In these situations, despite the advanced tumor stage, s ... Full text Link to item Cite

Cardiac tumors

Chapter · January 5, 2012 Cite

The 2010 Thoracic Surgery Residents Association workforce survey report: a view from the trenches.

Journal Article Ann Thorac Surg · December 2011 BACKGROUND: Workforce estimates suggest 11% of general surgery residents are considering careers in cardiothoracic (CT) surgery. In an effort to identify areas for programmatic improvement, we examined trends in thoracic surgery residents' perspectives on ... Full text Link to item Cite

Report of the 2010 society of thoracic surgeons congenital heart surgery practice and manpower survey.

Journal Article Ann Thorac Surg · August 2011 BACKGROUND: The Society of Thoracic Surgeons (STS) Workforce on Congenital Heart Surgery undertook a second subspecialty Practice and Manpower Survey (2005, 2010) to obtain contemporary data. METHODS: Preliminary research suggested a potential target group ... Full text Link to item Cite

Anomalous aortic origin of a coronary artery: preoperative diagnosis and surgical planning.

Journal Article World J Pediatr Congenit Heart Surg · July 1, 2011 BACKGROUND: Anomalous aortic origin of a coronary artery (AAOCA), the anomalous coronary artery arises from an inappropriate coronary sinus and travels between the aorta and pulmonary artery. Proper surgical management depends upon correct diagnosis and ac ... Full text Link to item Cite

Impact of oropharyngeal dysphagia on long-term outcomes of lung transplantation.

Journal Article Ann Thorac Surg · November 2010 BACKGROUND: Lung transplantation, definitive therapy for end-stage lung disease, is limited long-term by allograft dysfunction including bronchiolitis obliterans syndrome (BOS). Few modifiable risk factors for pulmonary transplant-related mortality are rec ... Full text Link to item Cite

Management of hemostasis in vascular surgery.

Journal Article Surgery · October 2007 The fate of the circulatory system in response to vascular injury is governed by a series of complex biochemical reactions involving cellular elements and plasma proteins. Alteration of this hemostatic balance can result in excessive bleeding or procoagula ... Full text Link to item Cite

Differential mapping of the amino acids mediating agonist and antagonist coordination with the human thromboxane A2 receptor protein.

Journal Article J Biol Chem · September 15, 2006 Despite the well documented involvement of thromboxane A(2) receptor (TPR) signaling in the pathogenesis of thrombotic diseases, there are currently no rationally designed antagonists available for clinical use. To a large extent, this derives from a lack ... Full text Link to item Cite

Histopathology and transmurality of acute microwave lesions on the beating human atrium.

Journal Article Interact Cardiovasc Thorac Surg · June 2006 Microwave energy allows thoracoscopic beating-heart ablation for the treatment of atrial fibrillation. However, there is a paucity of data on the histologic effects of microwave energy on the beating human heart. This study aims to histopathologically char ... Full text Link to item Cite

Detecting pheochromocytoma: defining the most sensitive test.

Journal Article Ann Surg · January 2006 OBJECTIVE: To define the most sensitive biochemical test to establish the diagnosis of pheochromocytoma and also to assess the potential role of iodine 131-labeled metaiodobenzylguanidine scintigraphy (I-MIBG) in the diagnosis of this tumor. SUMMARY BACKGR ... Full text Link to item Cite

Mapping of a ligand-binding site for the human thromboxane A2 receptor protein.

Journal Article J Biol Chem · May 10, 2002 The human thromboxane A(2) (TP) receptor, a member of the G protein-coupled receptor superfamily, consists of seven transmembrane segments. Attempts to elucidate the specific segment(s) that define the receptor ligand-binding pocket have produced less than ... Full text Link to item Cite

Formulations which increase the size of lipoplexes prevent serum-associated inhibition of transfection.

Journal Article J Gene Med · 2000 BACKGROUND: Cationic lipids are the most widely used nonviral vectors for gene delivery. Upon complexation to DNA, they offer a nonimmunogenic alternative to viral gene transfer. Unfortunately, their in vivo application has been limited due to a serum-asso ... Full text Link to item Cite

Synthesis and biological characterization of sqbazide, a novel biotinylated photoaffinity probe for the study of the human platelet thromboxane A2 receptor.

Journal Article Bioorg Med Chem Lett · October 18, 1999 SQBAzide, a biotinylated, azido derivative of the TXA2 receptor antagonist, SQ31,491, was synthesized and characterized. The compound specifically inhibited human platelet aggregation mediated by TXA2 receptor activation and irreversibly labeled platelet T ... Full text Link to item Cite

Worldwide Experience of a Durable Centrifugal Flow Pump in Pediatric Patients.

Journal Article Semin Thorac Cardiovasc Surg The primary objectives of this study were to describe the characteristics and survival outcomes for children supported with the HeartWare HVAD® system from the global community. This was a retrospective survey of patients <18 years of age with an HVAD® sys ... Full text Link to item Cite

Commentary: Bigger is Not Always Better.

Journal Article Semin Thorac Cardiovasc Surg Full text Link to item Cite