Kerry L. Lee

Journal Article J Am Heart Assoc · February 7, 2023 Background Women with atrial fibrillation (AF) demonstrate more AF-related symptoms and worse quality of life (QOL). Whether increased use of ablation in women reduces sex-related QOL differences is unknown. Sex-related outcomes for ablation versus drug th ... Full text Open Access Link to item Cite

Influence of atrial fibrillation type on outcomes of ablation vs. drug therapy: results from CABANA.

Journal Article Europace · October 13, 2022 AIMS: Influence of atrial fibrillation (AF) type on outcomes seen with catheter ablation vs. drug therapy is incompletely understood. This study assesses the impact of AF type on treatment outcomes in the Catheter Ablation vs. Antiarrhythmic Drug Therapy f ... Full text Open Access Link to item Cite

Cost-Effectiveness of Catheter Ablation Versus Antiarrhythmic Drug Therapy in Atrial Fibrillation: The CABANA Randomized Clinical Trial.

Journal Article Circulation · August 16, 2022 BACKGROUND: In the CABANA trial (Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation), catheter ablation did not significantly reduce the primary end point of death, disabling stroke, serious bleeding, or cardiac arrest compared with d ... Full text Link to item Cite

Association Between Age and Outcomes of Catheter Ablation Versus Medical Therapy for Atrial Fibrillation: Results From the CABANA Trial.

Journal Article Circulation · March 15, 2022 BACKGROUND: Observational data suggest that catheter ablation may be safe and effective to treat younger and older patients with atrial fibrillation. No large, randomized trial has examined this issue. This report describes outcomes according to age at ent ... Full text Open Access Link to item Cite

Renal function and coronary bypass surgery in patients with ischemic heart failure.

Journal Article J Thorac Cardiovasc Surg · February 2022 OBJECTIVE: Chronic kidney disease is a known risk factor in cardiovascular disease, but its influence on treatment effect of bypass surgery remains unclear. We assessed the influence of chronic kidney disease on 10-year mortality and cardiovascular outcome ... Full text Link to item Cite

CABANA: underpowered and with detrimental protocol changes: is 'ablation salvation'?-Reply by the authors of the CABANA trial.

Journal Article Europace · January 4, 2022 Full text Link to item Cite

Factors and outcomes associated with improved left ventricular systolic function in patients with cardiomyopathy.

Journal Article Cardiol J · 2022 BACKGROUND: Many patients in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) had a significant improvement (> 10%) in the left ventricular ejection fraction (LVEF) during the course of the study, but the factors and outcomes associated with such ... Full text Link to item Cite

Outcomes for patients with anterior myocardial infarction and prior cardiac arrest in the home automated external defibrillator trial (HAT).

Journal Article Resuscitation · November 2021 BACKGROUND: Patients with sudden cardiac arrest occurring in the acute phase of myocardial infarction (MI-SCA) are believed to be at similar risk of death after revascularization compared with MI patients without SCA (MI-no SCA). Among patients with anteri ... Full text Link to item Cite

Treatment-Related Changes in Left Atrial Structure in Atrial Fibrillation: Findings From the CABANA Imaging Substudy.

Journal Article Circulation. Arrhythmia and electrophysiology · May 2021 [Figure: see text]. ... Full text Open Access Cite

Ablation Versus Drug Therapy for Atrial Fibrillation in Heart Failure: Results From the CABANA Trial.

Journal Article Circulation · April 6, 2021 BACKGROUND: In patients with heart failure and atrial fibrillation (AF), several clinical trials have reported improved outcomes, including freedom from AF recurrence, quality of life, and survival, with catheter ablation. This article describes the treatm ... Full text Open Access Link to item Cite

Differential Outcomes With Edetate Disodium-Based Treatment Among Stable Post Anterior vs. Non-Anterior Myocardial Infarction Patients.

Journal Article Cardiovasc Revasc Med · November 2020 BACKGROUND: The Trial to Assess Chelation Therapy (TACT) found that chelation therapy significantly reduced clinical events in patients with a history of myocardial infarction (MI). The initial report of TACT included the observation of an interaction betw ... Full text Link to item Cite

Possible differential benefits of edetate disodium in post-myocardial infarction patients with diabetes treated with different hypoglycemic strategies in the Trial to Assess Chelation Therapy (TACT).

Journal Article J Diabetes Complications · August 2020 BACKGROUND: The NIH-funded Trial to Assess Chelation Therapy (TACT) randomized 1708 stable patients age ≥50 who were ≥6 months post myocardial infarction to 40 infusions of an edetate disodium-based regimen or placebo. In 633 patients with diabetes, edetat ... Full text Link to item Cite

Long-Term Outcomes of Implantable Cardioverter-Defibrillator Therapy in the SCD-HeFT.

Journal Article J Am Coll Cardiol · July 28, 2020 BACKGROUND: The SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial) randomized 2,521 patients with moderate heart failure (HF) to amiodarone, placebo drug, or implantable cardioverter-defibrillator (ICD) therapy. Original trial follow-up ended October 3 ... Full text Link to item Cite

Recurrence of Atrial Fibrillation After Catheter Ablation or Antiarrhythmic Drug Therapy in the CABANA Trial.

Journal Article J Am Coll Cardiol · June 30, 2020 BACKGROUND: The CABANA (Catheter Ablation Versus Antiarrhythmic Drug Therapy for Atrial Fibrillation) trial randomized 2,204 patients with atrial fibrillation (AF) to catheter ablation or drug therapy. Analysis by intention-to-treat showed a nonsignificant ... Full text Open Access Link to item Cite

Incremental prognostic value of echocardiography of left ventricular remodeling and diastolic function in STICH trial.

Journal Article Cardiovasc Ultrasound · May 28, 2020 AIMS: We sought to determine which echocardiographic markers of left ventricular (LV) remodeling and diastolic dysfunction can contribute as incremental and independent prognostic information in addition to current clinical risk markers of ischemic LV syst ... Full text Link to item Cite

Discordances between predicted and actual risk in obese patients with suspected cardiac ischaemia.

Journal Article Heart · February 2020 OBJECTIVES: To test the relationship between increasing severity of obesity, calculated risk and observed outcomes. METHODS: Patients with symptoms suggestive of coronary artery disease (CAD) (n=10 003) were stratified according to body mass index (BMI). W ... Full text Link to item Cite

CABG Improves Outcomes in Patients With Ischemic Cardiomyopathy: 10-Year Follow-Up of the STICH Trial.

Journal Article JACC Heart Fail · October 2019 OBJECTIVES: The authors investigated the impact of coronary artery bypass grafting (CABG) on first and recurrent hospitalization in this population. BACKGROUND: In the STICH (Surgical Treatment for Ischemic Heart Failure) trial, CABG reduced all-cause deat ... Full text Link to item Cite

Catheter Ablation Compared With Drug Therapy for Atrial Fibrillation-Reply.

Journal Article JAMA · September 17, 2019 Full text Link to item Cite

Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy.

Journal Article N Engl J Med · August 22, 2019 BACKGROUND: The role of assessment of myocardial viability in identifying patients with ischemic cardiomyopathy who might benefit from surgical revascularization remains controversial. Furthermore, although improvement in left ventricular function is one o ... Full text Link to item Cite

The effect of EDTA-based chelation on patients with diabetes and peripheral artery disease in the Trial to Assess Chelation Therapy (TACT).

Journal Article J Diabetes Complications · July 2019 OBJECTIVE: Approximately 1 in 7 US adults have diabetes; and over 60% of deaths in patients with diabetes have cardiac disease as a principal or contributing cause. Both coronary and peripheral artery disease (PAD) identify high-risk cohorts among patients ... Full text Link to item Cite

Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial.

Journal Article JAMA · April 2, 2019 IMPORTANCE: Catheter ablation is more effective than drug therapy in restoring sinus rhythm in patients with atrial fibrillation (AF), but its incremental effect on long-term quality of life (QOL) is uncertain. OBJECTIVE: To determine whether catheter abla ... Full text Link to item Cite

Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial.

Journal Article JAMA · April 2, 2019 IMPORTANCE: Catheter ablation is effective in restoring sinus rhythm in atrial fibrillation (AF), but its effects on long-term mortality and stroke risk are uncertain. OBJECTIVE: To determine whether catheter ablation is more effective than conventional me ... Full text Open Access Link to item Cite

Stress Testing Versus CT Angiography in Patients With Diabetes and Suspected Coronary Artery Disease.

Journal Article J Am Coll Cardiol · March 5, 2019 BACKGROUND: The optimal noninvasive test (NIT) for patients with diabetes and stable symptoms of coronary artery disease (CAD) is unknown. OBJECTIVES: The purpose of this study was to assess whether a diagnostic strategy based on coronary computed tomograp ... Full text Link to item Cite

Sex differences in management and outcomes of patients with stable symptoms suggestive of coronary artery disease: Insights from the PROMISE trial.

Journal Article Am Heart J · February 2019 BACKGROUND: Although sex differences exist in the management of acute coronary syndromes, less is known about the management and outcomes of women and men with suspected coronary artery disease being evaluated with noninvasive testing (NIT). METHODS: We in ... Full text Link to item Cite

Predictive Model for High-Risk Coronary Artery Disease.

Journal Article Circ Cardiovasc Imaging · February 2019 BACKGROUND: Patients with high-risk coronary artery disease (CAD) may be difficult to identify. METHODS: Using the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) cohort randomized to coronary computed tomographic angiography ( ... Full text Link to item Cite

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes.

Journal Article N Engl J Med · January 24, 2019 BACKGROUND: The cardiovascular safety profile of dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2 that promotes glucosuria in patients with type 2 diabetes, is undefined. METHODS: We randomly assigned patients with type 2 diabetes who ... Full text Link to item Cite

Effects of obesity on noninvasive test results in patients with suspected cardiac ischemia: Insights from the PROMISE trial.

Journal Article J Cardiovasc Comput Tomogr · 2019 BACKGROUND: Obesity is a risk factor for coronary artery disease (CAD), but adiposity may mimic symptoms of CAD and reduce the accuracy of diagnostic testing. METHODS: Patients from the PROMISE trial (n = 8889) were classified according to body mass index ... Full text Link to item Cite

Reply.

Journal Article Clin Gastroenterol Hepatol · October 2018 Full text Open Access Link to item Cite

The association between blood pressure and long-term outcomes of patients with ischaemic cardiomyopathy with and without surgical revascularization: an analysis of the STICH trial.

Journal Article Eur Heart J · October 1, 2018 AIMS: Hypertension (HTN) is a well-known contributor to cardiovascular disease, including heart failure (HF) and coronary artery disease, and is the leading risk factor for premature death world-wide. A J- or U-shaped relationship has been suggested betwee ... Full text Link to item Cite

Variability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction.

Journal Article JAMA Netw Open · August 3, 2018 IMPORTANCE: Clinical decisions are frequently based on measurement of left ventricular ejection fraction (LVEF). Limited information exists regarding inconsistencies in LVEF measurements when determined by various imaging modalities and the potential impac ... Full text Link to item Cite

Improving the Use of Primary Prevention Implantable Cardioverter-Defibrillators Therapy With Validated Patient-Centric Risk Estimates.

Journal Article JACC Clin Electrophysiol · August 2018 OBJECTIVES: The authors previously developed the Seattle Proportional Risk Model (SPRM) in systolic heart failure patients without implantable cardioverter-defibrillators (ICDs)to predict the proportion of deaths that were sudden. They subsequently validat ... Full text Link to item Cite

Impact of Intubation Time on Survival following Coronary Artery Bypass Grafting: Insights from the Surgical Treatment for Ischemic Heart Failure (STICH) Trial.

Journal Article J Cardiothorac Vasc Anesth · June 2018 OBJECTIVE: The authors aimed to assess determinants of intubation time and evaluate its impact on 30-day and 1-year postoperative survival in Surgical Treatment for Ischemic Heart Failure (STICH) trial patients. DESIGN, SETTING, PARTICIPANTS, AND INTERVENT ... Full text Link to item Cite

Implantable cardioverter-defibrillators in heart failure patients with reduced ejection fraction and diabetes.

Journal Article Eur J Heart Fail · June 2018 AIM: There is limited information on the outcomes after primary prevention implantable cardioverter-defibrillator (ICD) implantation in patients with heart failure (HF) and diabetes. This analysis evaluates the effectiveness of a strategy of ICD plus medic ... Full text Link to item Cite

Catheter Ablation versus Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) Trial: Study Rationale and Design.

Journal Article Am Heart J · May 2018 The Catheter Ablation Versus Anti-arrhythmic Drug Therapy for Atrial Fibrillation (CABANA,NCT00911508)(1) trial is testing the hypothesis that the treatment strategy of percutaneous left atrial catheter ablation for the purpose of eliminating atrial fibril ... Full text Link to item Cite

The External Validity of Prediction Models for the Diagnosis of Obstructive Coronary Artery Disease in Patients With Stable Chest Pain: Insights From the PROMISE Trial.

Journal Article JACC Cardiovasc Imaging · March 2018 OBJECTIVES: This study sought to externally validate prediction models for the presence of obstructive coronary artery disease (CAD). BACKGROUND: A better assessment of the probability of CAD may improve the identification of patients who benefit from noni ... Full text Link to item Cite

Sex Difference in Patients With Ischemic Heart Failure Undergoing Surgical Revascularization: Results From the STICH Trial (Surgical Treatment for Ischemic Heart Failure).

Journal Article Circulation · February 20, 2018 BACKGROUND: Female sex is conventionally considered a risk factor for coronary artery bypass grafting (CABG) and has been included as a poor prognostic factor in multiple cardiac operative risk evaluation scores. We aimed to investigate the association of ... Full text Open Access Link to item Cite

Use of High-Risk Coronary Atherosclerotic Plaque Detection for Risk Stratification of Patients With Stable Chest Pain: A Secondary Analysis of the PROMISE Randomized Clinical Trial.

Journal Article JAMA Cardiol · February 1, 2018 IMPORTANCE: Coronary computed tomographic angiography (coronary CTA) can characterize coronary artery disease, including high-risk plaque. A noninvasive method of identifying high-risk plaque before major adverse cardiovascular events (MACE) could provide ... Full text Link to item Cite

Effect of high-dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to Assess Chelation Therapy (TACT).

Journal Article Am Heart J · January 2018 IMPORTANCE: In a prespecified subgroup analysis of participants not on statin therapy at baseline in the TACT, a high-dose complex oral multivitamins and multimineral regimen was found to have a large unexpected benefit compared with placebo. The regimen t ... Full text Link to item Cite

Prognostic Value of Coronary Artery Calcium in the PROMISE Study (Prospective Multicenter Imaging Study for Evaluation of Chest Pain).

Journal Article Circulation · November 21, 2017 BACKGROUND: Coronary artery calcium (CAC) is an established predictor of future major adverse atherosclerotic cardiovascular events in asymptomatic individuals. However, limited data exist as to how CAC compares with functional testing (FT) in estimating p ... Full text Link to item Cite

Noninvasive FFR Derived From Coronary CT Angiography: Management and Outcomes in the PROMISE Trial.

Journal Article JACC Cardiovasc Imaging · November 2017 OBJECTIVES: The purpose of this study was to determine whether noninvasive fractional flow reserve derived from computed tomography (FFRCT) predicts coronary revascularization and outcomes and whether its addition improves efficiency of referral to invasiv ... Full text Link to item Cite

Predicting appropriate shocks in patients with heart failure: Patient level meta-analysis from SCD-HeFT and MADIT II.

Conference J Cardiovasc Electrophysiol · November 2017 BACKGROUND: No precise tools exist to predict appropriate shocks in patients with a primary prevention ICD. We sought to identify characteristics predictive of appropriate shocks in patients with a primary prevention implantable cardioverter defibrillator ... Full text Link to item Cite

Impact of Diabetes Mellitus on the Evaluation of Stable Chest Pain Patients: Insights From the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) Trial.

Journal Article J Am Heart Assoc · October 31, 2017 BACKGROUND: The impact of diabetes mellitus on the clinical presentation and noninvasive test (NIT) results among stable outpatients presenting with symptoms suggestive of coronary artery disease (CAD) has not been well described. METHODS AND RESULTS: The ... Full text Link to item Cite

Quantifying sociodemographic and income disparities in medical therapy and lifestyle among symptomatic patients with suspected coronary artery disease: a cross-sectional study in North America.

Journal Article BMJ Open · September 29, 2017 OBJECTIVES: To evaluate potential gaps in preventive medical therapy and healthy lifestyle practices among symptomatic patients with suspected coronary artery disease (CAD) seeing primary care physicians and cardiologists and how gaps vary by sociodemograp ... Full text Link to item Cite

New York Heart Association class and the survival benefit from primary prevention implantable cardioverter defibrillators: A pooled analysis of 4 randomized controlled trials.

Conference Am Heart J · September 2017 BACKGROUND: Primary prevention implantable cardioverter defibrillator (ICD) reduce all-cause mortality by reducing sudden cardiac death. There are conflicting data regarding whether patients with more advanced heart failure derive ICD benefit owing to the ... Full text Link to item Cite

Prognostic Value of Noninvasive Cardiovascular Testing in Patients With Stable Chest Pain: Insights From the PROMISE Trial (Prospective Multicenter Imaging Study for Evaluation of Chest Pain).

Journal Article Circulation · June 13, 2017 BACKGROUND: Optimal management of patients with stable chest pain relies on the prognostic information provided by noninvasive cardiovascular testing, but there are limited data from randomized trials comparing anatomic with functional testing. METHODS: In ... Full text Link to item Cite

Primary Prevention Implantable Cardioverter Defibrillators in Patients With Nonischemic Cardiomyopathy: A Meta-analysis.

Journal Article JAMA Cardiol · June 1, 2017 IMPORTANCE: Conflicting data have emerged on the efficacy of implantable cardioverter defibrillators (ICDs) for primary prevention of sudden cardiac death (primary prevention ICDs) in patients with nonischemic cardiomyopathy. OBJECTIVE: To investigate the ... Full text Link to item Cite

Identification of Patients With Stable Chest Pain Deriving Minimal Value From Noninvasive Testing: The PROMISE Minimal-Risk Tool, A Secondary Analysis of a Randomized Clinical Trial.

Journal Article JAMA Cardiol · April 1, 2017 IMPORTANCE: Guidelines recommend noninvasive testing for patients with stable chest pain, although many subsequently have normal test results and no adverse clinical events. OBJECTIVE: To describe a risk tool developed to use only pretest clinical data to ... Full text Link to item Cite

Sudden Cardiac Death in Patients With Ischemic Heart Failure Undergoing Coronary Artery Bypass Grafting: Results From the STICH Randomized Clinical Trial (Surgical Treatment for Ischemic Heart Failure).

Journal Article Circulation · March 21, 2017 BACKGROUND: The risk of sudden cardiac death (SCD) in patients with heart failure after coronary artery bypass graft surgery (CABG) has not been examined in a contemporary clinical trial of surgical revascularization. This analysis describes the incidence, ... Full text Link to item Cite

Comparison of visual assessment of coronary stenosis with independent quantitative coronary angiography: Findings from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.

Journal Article Am Heart J · February 2017 BACKGROUND: The outcomes in patients by visual assessment and quantitative coronary angiography (QCA) for obstructive coronary artery disease (CAD) are not known. Our objectives were to compare visual and QCA estimates of obstructive CAD and to assess thei ... Full text Link to item Cite

An age- and sex-specific gene expression score is associated with revascularization and coronary artery disease: Insights from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.

Journal Article Am Heart J · February 2017 BACKGROUND: Identifying predictors of coronary artery disease (CAD)-related procedures and events remains a priority. METHODS: We measured an age- and sex-specific gene expression score (ASGES) previously validated to detect obstructive CAD (oCAD) in sympt ... Full text Link to item Cite

Safety of coronary CT angiography and functional testing for stable chest pain in the PROMISE trial: A randomized comparison of test complications, incidental findings, and radiation dose.

Journal Article J Cardiovasc Comput Tomogr · 2017 BACKGROUND: Coronary computed tomography angiography (CTA) and functional testing strategies for stable chest pain yield similar outcomes; one aspect that may guide test choice is safety. METHODS: We compared test safety (test complications, incidental fin ... Full text Open Access Link to item Cite

Understanding the Role of P Values and Hypothesis Tests in Clinical Research.

Journal Article JAMA Cardiol · December 1, 2016 P values and hypothesis testing methods are frequently misused in clinical research. Much of this misuse appears to be owing to the widespread, mistaken belief that they provide simple, reliable, and objective triage tools for separating the true and impor ... Full text Link to item Cite

Predictive Model for High-Risk Coronary Artery Disease: An Analysis From PROMISE

Conference CIRCULATION · November 11, 2016 Link to item Cite

Predicting Appropriate Shocks In Patients With Heart Failure: Patient Level Meta-analysis From SCD-HeFT and Madit II

Conference CIRCULATION · November 11, 2016 Link to item Cite

New York Heart Association Class and the Mortality Benefit From Primary Prevention Implantable Cardioverter Defibrillator Use: A Pooled Analysis of 4 Randomized Control Trials

Conference CIRCULATION · November 11, 2016 Link to item Cite

Ten-Year Outcomes After Coronary Artery Bypass Grafting According to Age in Patients With Heart Failure and Left Ventricular Systolic Dysfunction: An Analysis of the Extended Follow-Up of the STICH Trial (Surgical Treatment for Ischemic Heart Failure).

Journal Article Circulation · November 1, 2016 BACKGROUND: Advancing age is associated with a greater prevalence of coronary artery disease in heart failure with reduced ejection fraction and with a higher risk of complications after coronary artery bypass grafting (CABG). Whether the efficacy of CABG ... Full text Link to item Cite

Changes in Medical Therapy and Lifestyle After Anatomical or Functional Testing for Coronary Artery Disease.

Journal Article J Am Heart Assoc · October 12, 2016 BACKGROUND: Diagnostic testing in the care of patients newly presenting with symptoms suggestive of coronary artery disease may influence risk factor management, independent of test type or test results. However, little is known about changes in medication ... Full text Open Access Link to item Cite

Economic Outcomes With Anatomical Versus Functional Diagnostic Testing for Coronary Artery Disease.

Journal Article Ann Intern Med · July 19, 2016 BACKGROUND: PROMISE (PROspective Multicenter Imaging Study for Evaluation of Chest Pain) found that initial use of at least 64-slice multidetector computed tomography angiography (CTA) versus functional diagnostic testing strategies did not improve clinica ... Full text Open Access Link to item Cite

Sex Differences in Functional and CT Angiography Testing in Patients With Suspected Coronary Artery Disease.

Journal Article J Am Coll Cardiol · June 7, 2016 BACKGROUND: Although risk stratification is an important goal of cardiac noninvasive tests (NITs), few contemporary data exist on the prognostic value of different NITs according to patient sex. OBJECTIVES: The goal of this study was to compare the results ... Full text Link to item Cite

Quality-of-Life Outcomes With Anatomic Versus Functional Diagnostic Testing Strategies in Symptomatic Patients With Suspected Coronary Artery Disease: Results From the PROMISE Randomized Trial.

Journal Article Circulation · May 24, 2016 BACKGROUND: The Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial found that initial use of ≥64 detector-row computed tomography angiography versus standard functional testing strategies (exercise ECG, stress nuclear method ... Full text Link to item Cite

Heavy Metals, Cardiovascular Disease, and the Unexpected Benefits of Chelation Therapy.

Journal Article J Am Coll Cardiol · May 24, 2016 This review summarizes evidence from 2 lines of research previously thought to be unrelated: the unexpectedly positive results of TACT (Trial to Assess Chelation Therapy), and a body of epidemiological data showing that accumulation of biologically active ... Full text Link to item Cite

Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy.

Journal Article N Engl J Med · April 21, 2016 BACKGROUND: The survival benefit of a strategy of coronary-artery bypass grafting (CABG) added to guideline-directed medical therapy, as compared with medical therapy alone, in patients with coronary artery disease, heart failure, and severe left ventricul ... Full text Link to item Cite

Sex Differences in Demographics, Risk Factors, Presentation, and Noninvasive Testing in Stable Outpatients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial.

Journal Article JACC Cardiovasc Imaging · April 2016 OBJECTIVES: The aim of this study was to determine whether presentation, risk assessment, testing choices, and results differ by sex in stable symptomatic outpatients with suspected coronary artery disease (CAD). BACKGROUND: Although established CAD presen ... Full text Link to item Cite

IDENTIFYING STABLE CHEST PAIN PATIENTS WITH SUSPECTED CORONARY DISEASE IN WHOM NONINVASIVE TESTING MAY BE SAFELY DEFERRED: INSIGHTS FROM THE PROMISE TRIAL (PROSPECTIVE MULTICENTER IMAGING STUDY FOR EVALUATION OF CHEST PAIN)

Conference Journal of the American College of Cardiology · April 2016 Full text Cite

Cardiac resynchronization therapy in chronic heart failure with moderately reduced left ventricular ejection fraction: Lessons from the Multicenter InSync Randomized Clinical Evaluation MIRACLE EF study.

Journal Article Int J Cardiol · January 1, 2016 BACKGROUND: The benefits of CRT for symptomatic heart failure (HF) patients with a wide QRS and reduced left ventricular ejection fraction (LVEF≤35%), are well established .Post-hoc subgroup analyses suggest that CRT benefit may extend to patients with LVE ... Full text Link to item Cite

Erratum: SCD-HeFT: Use of R-R interval statistics for long-term risk stratification for arrhythmic sudden cardiac death (HeartRhythm Journal (2015) 12 (2058-2066))

Journal Article Heart Rhythm · December 1, 2015 Full text Cite

Behind the Looking Glass: Comparing Time to First Event versus Multiple Events Analyses in a Post-myocardial Infarction Clinical Trial

Conference CIRCULATION · November 10, 2015 Link to item Cite

Safety of Anatomic versus Functional Diagnostic Testing: Insights From the PROMISE Trial (PROspective Multicenter Imaging Study for Evaluation of Chest Pain)

Conference CIRCULATION · November 10, 2015 Link to item Cite

Changes in Medical Therapy and Lifestyle After Anatomical Versus Functional Testing for Coronary Artery Disease: The PROMISE Trial (PROspective Multicenter Imaging Study for Evaluation of Chest Pain)

Conference · November 10, 2015 Introduction: Diagnostic testing may represent a “teachable moment” for patients newly presenting with symptoms suggestive of CAD and requiring further evaluation, and may influence risk factor management, independent of test results. However, little is kn ... Open Access Link to item Cite

SCD-HeFT: Use of R-R interval statistics for long-term risk stratification for arrhythmic sudden cardiac death.

Journal Article Heart Rhythm · October 2015 BACKGROUND: In the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT), a significant fraction of the patients with congestive heart failure ultimately did not die suddenly of arrhythmic causes. Patients with CHF will benefit from better tools to identi ... Full text Link to item Cite

Severity of Remodeling, Myocardial Viability, and Survival in Ischemic LV Dysfunction After Surgical Revascularization.

Journal Article JACC Cardiovasc Imaging · October 2015 OBJECTIVES: This study sought to test the hypothesis that end-systolic volume (ESV), as a marker of severity of left ventricular (LV) remodeling, influences the relationship between myocardial viability and survival in patients with coronary artery disease ... Full text Link to item Cite

TCT-284 Comparison of Visual Assessment of Coronary Stenosis with Independent Quantitative Coronary Angiography: Findings from the PROMISE Trial (PROspective Multicenter Imaging Study for Evaluation of chest pain)

Conference Journal of the American College of Cardiology · October 2015 Full text Cite

Influence of Baseline Characteristics, Operative Conduct, and Postoperative Course on 30-Day Outcomes of Coronary Artery Bypass Grafting Among Patients With Left Ventricular Dysfunction: Results From the Surgical Treatment for Ischemic Heart Failure (STICH) Trial.

Journal Article Circulation · August 25, 2015 BACKGROUND: Patients with severe left ventricular dysfunction, ischemic heart failure, and coronary artery disease suitable for coronary artery bypass grafting (CABG) are at higher risk for surgical morbidity and mortality. Paradoxically, those patients wi ... Full text Link to item Cite

CHA2DS2-VAS(C) and CHADS2 Scores Predict Adverse Clinical Events in Patients With Pacemakers and Sinus Node Dysfunction Independent of Atrial Fibrillation.

Journal Article Can J Cardiol · August 2015 BACKGROUND: CHA2DS2-VASc and CHADS2 scores were derived and validated for stroke-risk stratification in patients who have a diagnosis of atrial fibrillation (AF). We hypothesized that these scores would predict adverse cardiovascular events even in the abs ... Full text Link to item Cite

Clinical characteristics and outcomes of patients with and without diabetes in the Surgical Treatment for Ischemic Heart Failure (STICH) trial.

Journal Article Eur J Heart Fail · July 2015 AIMS: Hypothesis 1 of the Surgical Treatment for Ischemic Heart Failure (STICH) trial enrolled 1212 patients with an LVEF of ≤35% and CAD amenable to coronary artery bypass grafting (CABG). Patients were randomized to CABG and optimal medical therapy (MED) ... Full text Link to item Cite

Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes.

Journal Article N Engl J Med · June 18, 2015 BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardio ... Full text Link to item Cite

Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study.

Journal Article Circulation · May 19, 2015 BACKGROUND: Oxidative stress may contribute to heart failure (HF) progression. Inhibiting xanthine oxidase in hyperuricemic HF patients may improve outcomes. METHODS AND RESULTS: We randomly assigned 253 patients with symptomatic HF, left ventricular eject ... Full text Link to item Cite

Implication of right ventricular dysfunction on long-term outcome in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting with or without surgical ventricular reconstruction.

Journal Article J Thorac Cardiovasc Surg · May 2015 OBJECTIVE: Whether right ventricular dysfunction affects clinical outcome after coronary artery bypass grafting with or without surgical ventricular reconstruction is still unknown. The aim of the study was to assess the impact of right ventricular dysfunc ... Full text Link to item Cite

Outcomes of anatomical versus functional testing for coronary artery disease.

Journal Article N Engl J Med · April 2, 2015 BACKGROUND: Many patients have symptoms suggestive of coronary artery disease (CAD) and are often evaluated with the use of diagnostic testing, although there are limited data from randomized trials to guide care. METHODS: We randomly assigned 10,003 sympt ... Full text Link to item Cite

Authorship in a multicenter clinical trial: The Heart Failure-A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) Authorship and Publication (HAP) scoring system results.

Journal Article Am Heart J · April 2015 BACKGROUND: Few guidelines exist regarding authorship on manuscripts resulting from large multicenter trials. The HF-ACTION investigators devised a system to address assignment of authorship on trial publications and tested the outcomes in the course of co ... Full text Link to item Cite

Impact of surgical ventricular reconstruction on sphericity index in patients with ischaemic cardiomyopathy: follow-up from the STICH trial.

Journal Article Eur J Heart Fail · April 2015 AIMS: We sought to evaluate associations between baseline sphericity index (SI) and clinical outcome, and changes in SI after coronary artery bypass graft (CABG) surgery with or without surgical ventricular reconstruction (SVR) in ischaemic cardiomyopathy ... Full text Link to item Cite

Survival benefit of the primary prevention implantable cardioverter-defibrillator among older patients: does age matter? An analysis of pooled data from 5 clinical trials.

Journal Article Circ Cardiovasc Qual Outcomes · March 2015 BACKGROUND: The impact of patient age on the risks of death or rehospitalization after primary prevention implantable cardioverter-defibrillator (ICD) placement is uncertain. METHODS AND RESULTS: Data from 5 major ICD trials were merged: the Multicenter Au ... Full text Link to item Cite

Genetic variants are not associated with outcome in patients with coronary artery disease and left ventricular dysfunction: results of the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials.

Journal Article Cardiology · 2015 OBJECTIVES AND BACKGROUND: We evaluated the ability of 23 genetic variants to provide prognostic information in patients enrolled in the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials. METHODS: Patients assigned to STI ... Full text Link to item Cite

Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary artery bypass surgery: results of the Surgical Treatment for Ischemic Heart Failure trial.

Journal Article J Thorac Cardiovasc Surg · December 2014 OBJECTIVES: In the Surgical Treatment for Ischemic Heart Failure trial, surgical ventricular reconstruction plus coronary artery bypass surgery was not associated with a reduction in the rate of death or cardiac hospitalization compared with bypass alone. ... Full text Link to item Cite

Outcomes of implantable cardioverter-defibrillator use in patients with comorbidities: results from a combined analysis of 4 randomized clinical trials.

Journal Article JACC Heart Fail · December 2014 OBJECTIVES: The aim of this study was to determine if the benefit of implantable cardioverter-defibrillators (ICDs) is modulated by medical comorbidity. BACKGROUND: Primary prevention ICDs improve survival in patients at risk for sudden cardiac death. Thei ... Full text Link to item Cite

Sudden Cardiac Death in Patients with Ischemic Heart Failure Undergoing CABG: Results from the STICH trial

Journal Article CIRCULATION · November 25, 2014 Link to item Cite

Reply: circadian variations of ventricular arrhythmias and sleep-disordered breathing in HF patients.

Journal Article J Am Coll Cardiol · November 4, 2014 Full text Link to item Cite

Clinical implications of chronic heart failure phenotypes defined by cluster analysis.

Journal Article J Am Coll Cardiol · October 28, 2014 BACKGROUND: Classification of chronic heart failure (HF) is on the basis of criteria that may not adequately capture disease heterogeneity. Improved phenotyping may help inform research and therapeutic strategies. OBJECTIVES: This study used cluster analys ... Full text Link to item Cite

Erratum: Extent of coronary and myocardial disease and benefit from surgical revascularization in ischemic LV Dysfunction (Journal of the American College of Cardiology (2014) 12:64 (553-6))

Other Journal of the American College of Cardiology · October 7, 2014 Full text Cite

Adverse effects of first-degree AV-block in patients with sinus node dysfunction: data from the mode selection trial.

Journal Article Pacing Clin Electrophysiol · September 2014 BACKGROUND: Patients with a pacing indication and first-degree atrioventricular (AV)-block pose a clinical challenge. The prognostic impact of first-degree AV-block in patients with sinus node dysfunction and the impact of pacing in this setting are not kn ... Full text Link to item Cite

Extent of coronary and myocardial disease and benefit from surgical revascularization in ischemic LV dysfunction [Corrected].

Journal Article J Am Coll Cardiol · August 12, 2014 BACKGROUND: Patients with ischemic left ventricular dysfunction have higher operative risk with coronary artery bypass graft surgery (CABG). However, those whose early risk is surpassed by subsequent survival benefit have not been identified. OBJECTIVES: T ... Full text Link to item Cite

Independent data monitoring committees: preparing a path for the future.

Journal Article Am Heart J · August 2014 Independent data monitoring committees (IDMCs) were introduced to monitor patient safety and study conduct in randomized clinical trials (RCTs), but certain challenges regarding the utilization of IDMCs have developed. First, the roles and responsibilities ... Full text Link to item Cite

Exercise capacity and mortality in patients with ischemic left ventricular dysfunction randomized to coronary artery bypass graft surgery or medical therapy: an analysis from the STICH trial (Surgical Treatment for Ischemic Heart Failure).

Journal Article JACC Heart Fail · August 2014 OBJECTIVES: The objective of this study was to assess the prognostic significance of exercise capacity in patients with ischemic left ventricular (LV) dysfunction eligible for coronary artery bypass graft surgery (CABG). BACKGROUND: Poor exercise capacity ... Full text Link to item Cite

Differential Response to Low Dose Dopamine or Nesiritide in Patients with Acute Heart Failure and Renal Dysfunction in Accordance to LV EF: Sub-Group Analysis of the ROSE AHF Trial

Conference Journal of Cardiac Failure · August 2014 Full text Cite

Implantable cardioverter-defibrillators for primary prevention of sudden cardiac death in CKD: a meta-analysis of patient-level data from 3 randomized trials.

Journal Article Am J Kidney Dis · July 2014 BACKGROUND: The benefit of a primary prevention implantable cardioverter-defibrillator (ICD) among patients with chronic kidney disease is uncertain. STUDY DESIGN: Meta-analysis of patient-level data from randomized controlled trials. SETTING & POPULATION: ... Full text Link to item Cite

EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: The factorial group results of the Trial to Assess Chelation Therapy.

Journal Article Am Heart J · July 2014 BACKGROUND: Disodium ethylenediaminetetraacetic acid (EDTA) reduced adverse cardiac outcomes in a factorial trial also testing oral vitamins. This report describes the intent-to-treat comparison of the 4 factorial groups overall and in patients with diabet ... Full text Link to item Cite

Quality-of-life outcomes with a disodium EDTA chelation regimen for coronary disease: results from the trial to assess chelation therapy randomized trial.

Journal Article Circ Cardiovasc Qual Outcomes · July 2014 BACKGROUND: The National Institutes of Health.funded Trial to Assess Chelation Therapy (TACT) randomized 1708 stablecoronary disease patients aged .50 years who were .6 months post.myocardial infarction (2003.2010) to 40 infusions ofa multicomponent EDTA c ... Full text Link to item Cite

Unexpected deviation in circadian variation of ventricular arrhythmias: the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial).

Journal Article J Am Coll Cardiol · June 24, 2014 OBJECTIVES: This study sought to determine whether circadian patterns in ventricular arrhythmias (VAs) occur in a current primary prevention defibrillator (implantable cardioverter-defibrillator [ICD]) population. BACKGROUND: Cardiovascular events, includi ... Full text Link to item Cite

Use of the 6-min walk distance to identify variations in treatment benefits from implantable cardioverter-defibrillator and amiodarone: results from the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial).

Journal Article J Am Coll Cardiol · June 17, 2014 OBJECTIVES: The purpose of this study was to determine if 6-min walk test data assists in treatment decisions for patients with heart failure. BACKGROUND: In the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial), a pre-specified subgroup analysis show ... Full text Link to item Cite

PROspective Multicenter Imaging Study for Evaluation of chest pain: rationale and design of the PROMISE trial.

Journal Article Am Heart J · June 2014 BACKGROUND: Suspected coronary artery disease (CAD) is one of the most common, potentially life-threatening diagnostic problems clinicians encounter. However, no large outcome-based randomized trials have been performed to guide the selection of diagnostic ... Full text Link to item Cite

Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition.

Conference Blood · May 22, 2014 C-abl oncogene 1, nonreceptor tyrosine kinase (ABL1) kinase inhibitors such as imatinib mesylate (imatinib) are effective in managing chronic myeloid leukemia (CML) but incapable of eliminating leukemia stem cells (LSCs), suggesting that kinase-independent ... Full text Link to item Cite

Do patients with a left ventricular ejection fraction between 30% and 35% benefit from a primary prevention implantable cardioverter defibrillator?

Journal Article Int J Cardiol · March 1, 2014 Full text Link to item Cite

The effect of an EDTA-based chelation regimen on patients with diabetes mellitus and prior myocardial infarction in the Trial to Assess Chelation Therapy (TACT).

Journal Article Circ Cardiovasc Qual Outcomes · January 2014 BACKGROUND: The Trial to Assess Chelation Therapy (TACT) showed clinical benefit of an EDTA-based infusion regimen in patients aged ≥50 years with prior myocardial infarction. Diabetes mellitus before enrollment was a prespecified subgroup. METHODS AND RES ... Full text Link to item Cite

Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial.

Journal Article JAMA · December 18, 2013 IMPORTANCE: Small studies suggest that low-dose dopamine or low-dose nesiritide may enhance decongestion and preserve renal function in patients with acute heart failure and renal dysfunction; however, neither strategy has been rigorously tested. OBJECTIVE ... Full text Link to item Cite

Oral high-dose multivitamins and minerals after myocardial infarction: a randomized trial.

Journal Article Ann Intern Med · December 17, 2013 BACKGROUND: Whether high-dose multivitamins are effective for secondary prevention of atherosclerotic disease is unknown. OBJECTIVE: To assess whether oral multivitamins reduce cardiovascular events and are safe. DESIGN: Double-blind, placebo-controlled, 2 ... Full text Link to item Cite

Renal Optimization Strategies Evaluation in Acute Heart Failure (ROSE AHF) Trial

Journal Article CIRCULATION · December 17, 2013 Link to item Cite

Mechanisms of functional mitral regurgitation in ischemic cardiomyopathy determined by transesophageal echocardiography (from the Surgical Treatment for Ischemic Heart Failure Trial).

Journal Article Am J Cardiol · December 1, 2013 The mechanisms underlying functional mitral regurgitation (MR) and the relation between mechanism and severity of MR have not been evaluated in a large, multicenter, randomized controlled trial. Transesophageal echocardiography (TEE) was performed in 215 p ... Full text Link to item Cite

Impact of the Extent of Coronary and Myocardial Disease on the Treatment Effect of Surgical Revascularization in Patients With Ischemic Left Ventricular Dysfunction

Conference CIRCULATION · November 26, 2013 Link to item Cite

Clinical Benefit of EDTA-based Chelation Therapy and High-dose Oral Multivitamins and Multiminerals in TACT- An Expanded Comparison of 2 Factorial Groups

Conference CIRCULATION · November 26, 2013 Link to item Cite

CHADS2 and CHA2DS2-VASc scores are Predictive of Adverse Cardiovascular Outcomes in All Patients, Not Just Those With a Diagnosis of AF: an Analysis of the 2010 Patients From the MOST Trial

Conference CIRCULATION · November 26, 2013 Link to item Cite

Clinical Benefit of EDTA Chelation Therapy in Patients With Diabetes in the Trial to Assess Chelation Therapy (TACT)

Conference CIRCULATION · November 26, 2013 Link to item Cite

Reply: rapid rate nonsustained ventricular tachycardia found on ICD interrogation: relationship of RR-NSVT to outcomes in the SCD-HeFT trial.

Journal Article J Am Coll Cardiol · November 19, 2013 Full text Link to item Cite

Insights from the STICH trial: change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction.

Journal Article J Thorac Cardiovasc Surg · November 2013 OBJECTIVE: The present analysis of the Surgical Treatment for Ischemic Heart Failure randomized trial data examined the left ventricular volumes at baseline and 4 months after surgery to determine whether any magnitude of postoperative reduction in end-sys ... Full text Link to item Cite

The STICH trial (Surgical Treatment for Ischemic Heart Failure): mode-of-death results.

Journal Article JACC Heart Fail · October 2013 OBJECTIVES: This study sought to assess the effect of the addition of coronary artery bypass grafting (CABG) to medical therapy on mode of death in heart failure. BACKGROUND: Although CABG therapy is widely used in ischemic cardiomyopathy patients, there a ... Full text Link to item Cite

Targeting the kidney in acute heart failure: can old drugs provide new benefit? Renal Optimization Strategies Evaluation in Acute Heart Failure (ROSE AHF) trial.

Journal Article Circ Heart Fail · September 1, 2013 Full text Link to item Cite

Safety and efficacy of a totally subcutaneous implantable-cardioverter defibrillator.

Journal Article Circulation · August 27, 2013 BACKGROUND: The most frequent complications associated with implantable cardioverter-defibrillators (ICDs) involve the transvenous leads. A subcutaneous implantable cardioverter-defibrillator (S-ICD) has been developed as an alternative system. This study ... Full text Link to item Cite

Chelation therapy and cardiovascular outcomes--in reply.

Journal Article JAMA · July 24, 2013 Full text Link to item Cite

No benefit of a dual coil over a single coil ICD lead: evidence from the Sudden Cardiac Death in Heart Failure Trial.

Journal Article Heart Rhythm · July 2013 BACKGROUND: Dual coil implantable cardioverter-defibrillator (ICD) leads with a superior vena cava (SVC) electrode have been considered standard of care despite sparse data suggesting improved ICD defibrillation efficacy. SVC coils increase lead complexity ... Full text Link to item Cite

Xanthine oxidase inhibition for hyperuricemic heart failure patients: design and rationale of the EXACT-HF study.

Journal Article Circ Heart Fail · July 2013 Full text Link to item Cite

Survival benefit of primary prevention implantable cardioverter-defibrillator therapy after myocardial infarction: does time to implant matter? A meta-analysis using patient-level data from 4 clinical trials.

Journal Article Heart Rhythm · June 2013 BACKGROUND: Whether there is an optimal time to place an implantable cardioverter-defibrillator (ICD) more than 40 days after myocardial infarction (MI) in guideline-eligible patients is unknown. OBJECTIVE: To evaluate the effect of time from MI to randomi ... Full text Link to item Cite

Rapid-rate nonsustained ventricular tachycardia found on implantable cardioverter-defibrillator interrogation: relationship to outcomes in the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial).

Journal Article J Am Coll Cardiol · May 28, 2013 OBJECTIVES: The aim of this study was to examine rapid-rate nonsustained ventricular tachycardia (RR-NSVT) during routine implantable cardioverter-defibrillator (ICD) evaluation in patients with heart failure and its relationship to outcomes. BACKGROUND: T ... Full text Link to item Cite

Inducible myocardial ischemia and outcomes in patients with coronary artery disease and left ventricular dysfunction.

Journal Article J Am Coll Cardiol · May 7, 2013 OBJECTIVES: The study objectives were to test the hypotheses that ischemia during stress testing has prognostic value and identifies those patients with coronary artery disease (CAD) with left ventricular (LV) dysfunction who derive the greatest benefit fr ... Full text Link to item Cite

Influence of crossover on mortality in a randomized study of revascularization in patients with systolic heart failure and coronary artery disease.

Journal Article Circ Heart Fail · May 2013 BACKGROUND: To assess the influence of therapy crossovers on treatment comparisons and mortality at 5 years in patients with ischemic heart disease and heart failure randomly assigned to medical therapy alone (MED) or to MED and coronary artery bypass graf ... Full text Link to item Cite

Prognostic significance of biomarkers in predicting outcome in patients with coronary artery disease and left ventricular dysfunction: results of the biomarker substudy of the Surgical Treatment for Ischemic Heart Failure trials.

Journal Article Circ Heart Fail · May 2013 BACKGROUND: Patients with heart failure and coronary artery disease often undergo coronary artery bypass grafting, but assessment of the risk of an adverse outcome in these patients is difficult. To evaluate the ability of biomarkers to contribute independ ... Full text Link to item Cite

Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.

Journal Article JAMA · March 27, 2013 IMPORTANCE: Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise capacity in heart failure with preserved ejection fraction (HFPEF). OBJECTIVE: To determine the ef ... Full text Link to item Cite

Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial.

Journal Article JAMA · March 27, 2013 IMPORTANCE: Chelation therapy with disodium EDTA has been used for more than 50 years to treat atherosclerosis without proof of efficacy. OBJECTIVE: To determine if an EDTA-based chelation regimen reduces cardiovascular events. DESIGN, SETTING, AND PARTICI ... Full text Link to item Cite

Markers of decongestion, dyspnea relief, and clinical outcomes among patients hospitalized with acute heart failure.

Journal Article Circ Heart Fail · March 2013 BACKGROUND: Congestion is a primary driver of symptoms in patients with acute heart failure, and relief of congestion is a critical goal of therapy. Monitoring of response to therapy through the assessment of daily weights and net fluid loss is the current ... Full text Link to item Cite

Thyroid function in heart failure and impact on mortality.

Journal Article JACC Heart Fail · February 2013 OBJECTIVES: The aim of this study was to investigate whether patients with systolic heart failure (HF) and abnormal thyroid function are at increased risk for death. BACKGROUND: Thyroid hormone homeostasis is vital to the optimal functioning of the cardiov ... Full text Link to item Cite

Survival of patients receiving a primary prevention implantable cardioverter-defibrillator in clinical practice vs clinical trials.

Journal Article JAMA · January 2, 2013 IMPORTANCE: Randomized clinical trials have shown that implantable cardioverter-defibrillator (ICD) therapy saves lives. Whether the survival of patients who received an ICD in primary prevention clinical trials differs from that of trial-eligible patients ... Full text Link to item Cite

Reply: To PMID 22653543.

Journal Article Retina · 2013 Full text Link to item Cite

Influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy.

Journal Article Eur Heart J · January 2013 AIMS: The Surgical Treatment for Ischemic Heart Failure (STICH) trial demonstrated no overall benefit when surgical ventricular reconstruction (SVR) was added to coronary artery bypass grafting (CABG) in patients with ischaemic cardiomyopathy. The present ... Full text Link to item Cite

Ultrafiltration in decompensated heart failure with cardiorenal syndrome.

Journal Article N Engl J Med · December 13, 2012 BACKGROUND: Ultrafiltration is an alternative strategy to diuretic therapy for the treatment of patients with acute decompensated heart failure. Little is known about the efficacy and safety of ultrafiltration in patients with acute decompensated heart fai ... Full text Link to item Cite

Quality of Life Outcomes in the Trial to Assess Chelation Therapy (TACT)

Conference CIRCULATION · December 4, 2012 Link to item Cite

Cardiorenal Rescue Study in Acute Decompensated Heart Failure: Results of CARRESS-HF, for the Heart Failure Clinical Research Network

Conference CIRCULATION · December 4, 2012 Link to item Cite

Results of the Trial to Assess Chelation Therapy

Conference CIRCULATION · December 4, 2012 Link to item Cite

Obesity and the response to intensified diuretic treatment in decompensated heart failure: a DOSE trial substudy.

Journal Article J Card Fail · November 2012 BACKGROUND: Obesity could attenuate diuretic effectiveness in treatment of acute decompensated heart failure (HF). METHODS AND RESULTS: The DOSE trial randomized 308 subjects with acute HF to low- versus high-intensification intravenous diuretic therapy. W ... Full text Link to item Cite

PhosphdiesteRasE-5 Inhibition to Improve CLinical Status and EXercise Capacity in Diastolic Heart Failure (RELAX) trial: rationale and design.

Journal Article Circ Heart Fail · September 1, 2012 Heart failure (HF) with preserved ejection fraction (HFpEF) or “diastolic HF” accounts for approximately half of HF cases. To date, neurohumoral antagonists have failed to show a significant benefit on clinical outcomes in HFpEF. While our understanding of ... Full text Link to item Cite

Influence of mitral regurgitation repair on survival in the surgical treatment for ischemic heart failure trial.

Journal Article Circulation · May 29, 2012 BACKGROUND: Whether mitral valve repair during coronary artery bypass grafting (CABG) improves survival in patients with ischemic mitral regurgitation (MR) remains unknown. METHODS AND RESULTS: Patients with ejection fraction ≤35% and coronary artery disea ... Full text Link to item Cite

Vorapaxar in the secondary prevention of atherothrombotic events.

Journal Article N Engl J Med · April 12, 2012 BACKGROUND: Thrombin potently activates platelets through the protease-activated receptor PAR-1. Vorapaxar is a novel antiplatelet agent that selectively inhibits the cellular actions of thrombin through antagonism of PAR-1. METHODS: We randomly assigned 2 ... Full text Link to item Cite

Cardiorenal rescue study in acute decompensated heart failure: rationale and design of CARRESS-HF, for the Heart Failure Clinical Research Network.

Journal Article J Card Fail · March 2012 BACKGROUND: Worsening renal function is common among patients hospitalized for acute decompensated heart failure (ADHF). When this occurs, subsequent management decisions often pit the desire for effective decongestion against concerns about further worsen ... Full text Link to item Cite

Core lab analysis of baseline echocardiographic studies in the STICH trial and recommendation for use of echocardiography in future clinical trials.

Journal Article J Am Soc Echocardiogr · March 2012 BACKGROUND: The Surgical Treatment for Ischemic Heart Failure (STICH) randomized trial was designed to identify an optimal management strategy for patients with ischemic cardiomyopathy. Baseline echocardiographic examinations were required for all patients ... Full text Link to item Cite

Long-term survival of patients with ischemic cardiomyopathy treated by coronary artery bypass grafting versus medical therapy.

Journal Article Ann Thorac Surg · February 2012 BACKGROUND: We prospectively applied the Surgical Treatment of Ischemic Cardiomyopathy trial entry criteria to an observational database to determine whether coronary artery bypass grafting (CABG) decreases mortality compared with medical therapy (MED) for ... Full text Link to item Cite

Factors related to morbidity and mortality in patients with chronic heart failure with systolic dysfunction: the HF-ACTION predictive risk score model.

Journal Article Circ Heart Fail · January 2012 BACKGROUND: We aimed to develop a multivariable statistical model for risk stratification in patients with chronic heart failure with systolic dysfunction, using patient data that are routinely collected and easily obtained at the time of initial presentat ... Full text Link to item Cite

Design of the Trial to Assess Chelation Therapy (TACT).

Journal Article Am Heart J · January 2012 TACT is an National Institutes of Health-sponsored, randomized, double-blind, placebo-controlled, 2 × 2 factorial clinical trial testing the benefits and risks of 40 infusions of a multicomponent disodium EDTA chelation solution compared with placebo and o ... Full text Link to item Cite

Circulating Cardiac Troponin I as Detected By a High-Sensitivity Assay among Patients Hospitalized with Acute Decompensated Heart Failure

Journal Article CIRCULATION · November 22, 2011 Link to item Cite

Cystatin C as a Biomarker of Worsening Renal Function in Acute Heart Failure: Insights from the DOSE Study

Journal Article Journal of Cardiac Failure · August 2011 Full text Cite

Coronary-artery bypass surgery in patients with left ventricular dysfunction.

Journal Article N Engl J Med · April 28, 2011 BACKGROUND: The role of coronary-artery bypass grafting (CABG) in the treatment of patients with coronary artery disease and heart failure has not been clearly established. METHODS: Between July 2002 and May 2007, a total of 1212 patients with an ejection ... Full text Link to item Cite

Myocardial viability and survival in ischemic left ventricular dysfunction.

Journal Article N Engl J Med · April 28, 2011 BACKGROUND: The assessment of myocardial viability has been used to identify patients with coronary artery disease and left ventricular dysfunction in whom coronary-artery bypass grafting (CABG) will provide a survival benefit. However, the efficacy of thi ... Full text Link to item Cite

MARKERS OF CONGESTION, SYMPTOM RELIEF AND CLINICAL OUTCOMES AMONG PATIENTS HOSPITALIZED WITH ACUTE HEART FAILURE: DATA FROM THE DIURETIC OPTIMAL STRATEGY EVALUATION IN ACUTE HEART FAILURE STUDY

Conference Journal of the American College of Cardiology · April 2011 Full text Cite

DOES OBESITY AFFECT RESPONSE TO TREATMENT IN ACUTE DECOMPENSATED HEART FAILURE? A DIURETIC OPTIMIZATION STRATEGIES EVALUATION (DOSE) TRIAL SUBSTUDY

Conference Journal of the American College of Cardiology · April 2011 Full text Cite

Diuretic strategies in patients with acute decompensated heart failure.

Journal Article N Engl J Med · March 3, 2011 BACKGROUND: Loop diuretics are an essential component of therapy for patients with acute decompensated heart failure, but there are few prospective data to guide their use. METHODS: In a prospective, double-blind, randomized trial, we assigned 308 patients ... Full text Link to item Cite

Mortality benefits from implantable cardioverter-defibrillator therapy are not restricted to patients with remote myocardial infarction: an analysis from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article Heart Rhythm · March 2011 BACKGROUND: The implantable cardioverter-defibrillator (ICD) is an effective therapy for preventing sudden cardiac death (SCD) in patients with prior myocardial infarction (MI) and reduced left ventricular function; however, the optimal timing of ICD impla ... Full text Link to item Cite

An ECG index of myocardial scar enhances prediction of defibrillator shocks: an analysis of the Sudden Cardiac Death in Heart Failure Trial.

Journal Article Heart Rhythm · January 2011 BACKGROUND: Only a minority of patients receiving implantable cardioverter-defibrillators (ICDs) for the primary prevention of sudden death receive appropriate shocks, yet almost as many are subjected to inappropriate shocks and device complications. Ident ... Full text Link to item Cite

Cause-Specific Mortality in Patients with Prior Anterior Myocardial Infarction: Clinical Predictors Identified in the Home Automated External Defibrillator Trial

Conference CIRCULATION · November 23, 2010 Link to item Cite

No Benefit of a Dual Coil over a Single Coil ICD Lead: Evidence from SCD-HeFT

Journal Article CIRCULATION · November 23, 2010 Link to item Cite

Response to letter regarding article, impact of implantable cardioverter-defibrillator, amiodarone, and placebo on the mode of death in stable patients with heart failure: Analysis from the sudden cardiac death in heart failure trial

Journal Article Circulation · October 12, 2010 Full text Cite

The STICH trial: evidence-based conclusions.

Journal Article Eur J Heart Fail · October 2010 Full text Link to item Cite

A model for predicting mortality in acute ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention: results from the Assessment of Pexelizumab in Acute Myocardial Infarction Trial.

Journal Article Circ Cardiovasc Interv · October 2010 BACKGROUND: Accurate models to predict mortality are needed for risk stratification in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). METHODS AND RESULTS: We examined 5745 patie ... Full text Link to item Cite

Relation between time from myocardial infarction to enrolment and patient outcomes in the Multicenter UnSustained Tachycardia Trial.

Journal Article Europace · August 2010 AIMS: We sought to assess the relation between time from myocardial infarction (MI) to enrolment and patient outcomes and to examine the association between these outcomes and implantable cardioverter defibrillator (ICD) therapy. METHODS AND RESULTS: We an ... Full text Link to item Cite

Single-photon emission computed tomography myocardial perfusion imaging and the risk of sudden cardiac death in patients with coronary disease and left ventricular ejection fraction>35%.

Journal Article J Am Coll Cardiol · July 13, 2010 OBJECTIVES: The aim of this study was to determine whether single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an effective method of risk stratification for sudden cardiac death (SCD) in patients with coronary artery d ... Full text Link to item Cite

Maintenance of sinus rhythm and survival in patients with heart failure and atrial fibrillation.

Journal Article J Am Coll Cardiol · April 27, 2010 OBJECTIVES: The goal of this study was to evaluate the relationship between the presence of sinus rhythm and outcomes in patients with a history of congestive heart failure (CHF) and atrial fibrillation (AF). BACKGROUND: The value of sinus rhythm maintenan ... Full text Link to item Cite

Towards a new order in cardiovascular medicine: re-engineering through global collaboration.

Journal Article Eur Heart J · April 2010 Full text Link to item Cite

Quality of life effects of automatic external defibrillators in the home: results from the Home Automatic External Defibrillator Trial (HAT).

Journal Article Am Heart J · April 2010 BACKGROUND: Public access automatic external defibrillators (AEDs) can save lives, but most deaths from out-of-hospital sudden cardiac arrest occur at home. The Home Automatic External Defibrillator Trial (HAT) found no survival advantage for adding a home ... Full text Link to item Cite

Usefulness of the Duke Sudden Cardiac Death risk score for predicting sudden cardiac death in patients with angiographic (>75% narrowing) coronary artery disease.

Journal Article Am J Cardiol · December 15, 2009 The currently available sudden cardiac death (SCD) risk prediction tools fail to identify most at-risk patients and cannot delineate a specific patient's SCD risk. We sought to develop a tool to improve the risk stratification of patients with coronary art ... Full text Link to item Cite

Standardized reporting of bleeding complications for clinical investigations in acute coronary syndromes: a proposal from the academic bleeding consensus (ABC) multidisciplinary working group.

Journal Article Am Heart J · December 2009 BACKGROUND: Clinical trials of antithrombotic agents for the treatment of ACS routinely assess bleeding as a safety endpoint, but variation in bleeding definitions makes comparison of the relative safety of these agents difficult. METHODS: The ABC Multidis ... Full text Link to item Cite

Impact of implantable cardioverter-defibrillator, amiodarone, and placebo on the mode of death in stable patients with heart failure: analysis from the sudden cardiac death in heart failure trial.

Journal Article Circulation · December 1, 2009 BACKGROUND: The Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) demonstrated that implantable cardioverter-defibrillator (ICD) therapy reduces all-cause mortality in patients with New York Heart Association class II/III heart failure and a left vent ... Full text Link to item Cite

Quantification of Myocardial Scar Using a Simple ECG Tool Identifies Patients at Risk for Sudden Arrhythmic Death: An Analysis of SCD-HeFT

Conference CIRCULATION · November 3, 2009 Link to item Cite

SPECT Myocardial Perfusion Imaging and the Risk of Sudden Cardiac Death in Patients With Coronary Disease and Left Ventricular Ejection Fraction > 35%

Conference CIRCULATION · November 3, 2009 Link to item Cite

Method for establishing authorship in a multicenter clinical trial.

Journal Article Ann Intern Med · September 15, 2009 With the emergence of large multicenter trials over the past 20 years, the numbers of investigators involved and publications resulting from each study have grown exponentially. An efficient, fair, and effective way to establish authorship on study-related ... Full text Link to item Cite

Maximizing survival benefit with primary prevention implantable cardioverter-defibrillator therapy in a heart failure population.

Journal Article Circulation · September 8, 2009 BACKGROUND: Although implantable cardioverter-defibrillator (ICD) therapy reduces mortality in moderately symptomatic heart failure patients with an ejection fraction Full text Link to item Cite

Mode of induction of ventricular tachycardia and prognosis in patients with coronary disease: the Multicenter UnSustained Tachycardia Trial (MUSTT).

Journal Article J Cardiovasc Electrophysiol · August 2009 INTRODUCTION: Programmed stimulation is an important prognostic tool in the evaluation of patients with an ejection fraction Full text Link to item Cite

Response to letters regarding article, "role of microvolt t-wave alternans in assessment of arrhythmia vulnerability among patients with heart failure and systolic dysfunction: Primary results from the t-wave alternans sudden cardiac death in heart failure trial substudy"

Journal Article Circulation · July 21, 2009 Full text Cite

Atrial fibrillation and quality of life after pacemaker implantation for sick sinus syndrome: data from the Mode Selection Trial (MOST).

Journal Article Am Heart J · July 2009 BACKGROUND: In the Mode Selection Trial (MOST) of 2,010 patients with sinus node dysfunction, dual-chamber-paced patients had less atrial fibrillation (AF) and heart failure and had slightly improved health-related quality of life (QOL) compared with rate ... Full text Link to item Cite

Early versus delayed, provisional eptifibatide in acute coronary syndromes.

Journal Article N Engl J Med · May 21, 2009 BACKGROUND: Glycoprotein IIb/IIIa inhibitors are indicated in patients with acute coronary syndromes who are undergoing an invasive procedure. The optimal timing of the initiation of such therapy is unknown. METHODS: We compared a strategy of early, routin ... Full text Link to item Cite

Coronary bypass surgery with or without surgical ventricular reconstruction.

Journal Article N Engl J Med · April 23, 2009 BACKGROUND: Surgical ventricular reconstruction is a specific procedure designed to reduce left ventricular volume in patients with heart failure caused by coronary artery disease. We conducted a trial to address the question of whether surgical ventricula ... Full text Link to item Cite

Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial.

Journal Article JAMA · April 8, 2009 CONTEXT: Guidelines recommend that exercise training be considered for medically stable outpatients with heart failure. Previous studies have not had adequate statistical power to measure the effects of exercise training on clinical outcomes. OBJECTIVE: To ... Full text Link to item Cite

Early versus delayed, provisional eptifibatide in acute coronary syndromes

Journal Article Revista Portuguesa De Cardiologia · April 1, 2009 Cite

Ejection fraction assessment and survival: an analysis of the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article Am Heart J · December 2008 BACKGROUND: Ejection fraction (EF) is an important method of mortality prediction among cardiac patients, and has been used to identify the highest risk patients for enrollment in the defibrillator primary prevention trials. Evidence suggests that measures ... Full text Link to item Cite

Role of microvolt T-wave alternans in assessment of arrhythmia vulnerability among patients with heart failure and systolic dysfunction: primary results from the T-wave alternans sudden cardiac death in heart failure trial substudy.

Journal Article Circulation · November 11, 2008 BACKGROUND: Sudden cardiac death remains a leading cause of mortality despite advances in medical treatment for the prevention of ischemic heart disease and heart failure. Recent studies showed a benefit of implantable cardioverter defibrillator implantati ... Full text Link to item Cite

Single-photon emission computed tomography myocardial perfusion defects are associated with an increased risk of all-cause death, cardiovascular death, and sudden cardiac death.

Journal Article Circ Cardiovasc Imaging · November 2008 BACKGROUND: Single-photon emission computed tomography myocardial perfusion imaging defects are associated with increased all-cause mortality and cardiovascular death. However, it is unknown whether single-photon emission computed tomography myocardial per ... Full text Link to item Cite

Infrequent Need for Pacing Following Implantable Cardioverter-Defibrillator Shocks: Analysis of the Sudden Cardiac Death in Heart Failure Trial

Journal Article CIRCULATION · October 28, 2008 Link to item Cite

Mode of Induction of Ventricular Tachycardia and Prognosis in patients with Coronary Disease: The Multicenter UnSustained Tachycardia Trial (MUSTT)

Journal Article CIRCULATION · October 28, 2008 Link to item Cite

Implantable cardioverter defibrillator therapy in patients with prior coronary revascularization in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article J Cardiovasc Electrophysiol · October 2008 INTRODUCTION: We conducted this study to examine the effect of the ICD on the outcomes of patients with prior coronary revascularization enrolled in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) and to assess the association of time from coron ... Full text Link to item Cite

Prognostic importance of defibrillator shocks in patients with heart failure.

Journal Article N Engl J Med · September 4, 2008 BACKGROUND: Patients with heart failure who receive an implantable cardioverter-defibrillator (ICD) for primary prevention (i.e., prevention of a first life-threatening arrhythmic event) may later receive therapeutic shocks from the ICD. Information about ... Full text Link to item Cite

Quality of life with defibrillator therapy or amiodarone in heart failure.

Journal Article N Engl J Med · September 4, 2008 BACKGROUND: Implantable cardioverter-defibrillator (ICD) therapy significantly prolongs life in patients at increased risk for sudden death from depressed left ventricular function. However, whether this increased longevity is accompanied by deterioration ... Full text Link to item Cite

No benefit from defibrillation threshold testing in the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial).

Journal Article J Am Coll Cardiol · August 12, 2008 OBJECTIVES: This study investigated whether defibrillation threshold (DFT) testing during implantable cardioverter-defibrillator (ICD) implantation predicts clinical outcomes. BACKGROUND: Defibrillation testing is often performed during insertion of ICDs t ... Full text Link to item Cite

The authors reply

Journal Article New England Journal of Medicine · July 31, 2008 Cite

Home automated defibrillators after myocardial infarction - Reply

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · July 31, 2008 Link to item Cite

Primary prevention with defibrillator therapy in women: results from the Sudden Cardiac Death in Heart Failure Trial.

Journal Article J Cardiovasc Electrophysiol · July 2008 INTRODUCTION: The Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) demonstrated that implantable cardioverter defibrillator (ICD) therapy reduced overall mortality in patients with class II or III heart failure and left ventricular ejection fraction ... Full text Link to item Cite

Rhythm control versus rate control for atrial fibrillation and heart failure.

Journal Article N Engl J Med · June 19, 2008 BACKGROUND: It is common practice to restore and maintain sinus rhythm in patients with atrial fibrillation and heart failure. This approach is based in part on data indicating that atrial fibrillation is a predictor of death in patients with heart failure ... Full text Link to item Cite

Effects of intensive glucose lowering in type 2 diabetes.

Journal Article N Engl J Med · June 12, 2008 BACKGROUND: Epidemiologic studies have shown a relationship between glycated hemoglobin levels and cardiovascular events in patients with type 2 diabetes. We investigated whether intensive therapy to target normal glycated hemoglobin levels would reduce ca ... Full text Link to item Cite

Home use of automated external defibrillators for sudden cardiac arrest.

Journal Article N Engl J Med · April 24, 2008 BACKGROUND: The most common location of out-of-hospital sudden cardiac arrest is the home, a situation in which emergency medical services are challenged to provide timely care. Consequently, home use of an automated external defibrillator (AED) might offe ... Full text Link to item Cite

Syncope predicts the outcome of cardiomyopathy patients: analysis of the SCD-HeFT study.

Journal Article J Am Coll Cardiol · April 1, 2008 OBJECTIVES: The outcome of congestive heart failure (CHF) patients with syncope is understood incompletely. BACKGROUND: We analyzed data from patients enrolled in the SCD-HeFT (Sudden Cardiac Death Heart Failure Trial) to determine whether syncope predicte ... Full text Link to item Cite

Relationship between left ventricular dyssynchrony and functional capacity in moderate to severe heart failure: the HF-ACTION trial nuclear ancillary study

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 11, 2008 Link to item Cite

Rationale and design of the Home Automatic External Defibrillator Trial (HAT).

Journal Article Am Heart J · March 2008 Most cardiac arrests occur in the home, where emergency medical services (EMS) systems are challenged to provide timely care. Because a large proportion of sudden cardiac arrests (SCAs) are due to ventricular tachycardia or ventricular fibrillation, home u ... Full text Link to item Cite

Outcome in African Americans and other minorities in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article Am Heart J · March 2008 BACKGROUND: The SCD-HeFT demonstrated that implantable cardioverter/defibrillator (ICD) therapy significantly improved survival compared to medical therapy alone in stable moderately symptomatic heart failure patients with an ejection fraction < or = 35%. ... Full text Link to item Cite

Response to letter regarding article, "Risk of thromboembolism in heart failure: An analysis from the sudden cardiac death in heart failure trial (SCD-HeFT)" [4]

Journal Article Circulation · January 1, 2008 Full text Cite

The rationale and design of the Surgical Treatment for Ischemic Heart Failure (STICH) trial.

Journal Article J Thorac Cardiovasc Surg · December 2007 OBJECTIVES: The rationale and design of the Surgical Treatment for Ischemic Heart Failure trial is described. Before the Surgical Treatment for Ischemic Heart Failure trial, less than 1000 patients with ischemic cardiomyopathy had been studied in randomize ... Full text Link to item Cite

Dynamic mortality modeling in PCI-treated ST-elevation myocardial infarction: Implications for clinical decision making

Journal Article CIRCULATION · October 16, 2007 Link to item Cite

Impact of ischemic burden and revascularization on outcomes among patients receiving drug therapy versus an implantable cardioverter defibrillator in MUSTT: Evidence for ischemia induced proarrhythmia

Conference CIRCULATION · October 16, 2007 Link to item Cite

Patients who receive an implantable cardioverter defibrillator for MADIT-II criteria in clinical practice are different from patients enrolled in MADIT-II

Journal Article CIRCULATION · October 16, 2007 Link to item Cite

Do patients who meet SCD-HeFT criteria in clinical practice differ from patients enrolled in SCD-HeFT?

Conference CIRCULATION · October 16, 2007 Link to item Cite

Limitations of ejection fraction for prediction of sudden death risk in patients with coronary artery disease: lessons from the MUSTT study.

Journal Article J Am Coll Cardiol · September 18, 2007 OBJECTIVES: We determined the contribution of multiple variables to predict arrhythmic death and total mortality risk in patients with coronary disease and left ventricular dysfunction. We then constructed an algorithm to predict risk of mortality and sudd ... Full text Link to item Cite

Impact of rate-modulated pacing on quality of life and exercise capacity--evidence from the Advanced Elements of Pacing Randomized Controlled Trial (ADEPT).

Journal Article Heart Rhythm · September 2007 BACKGROUND: Ninety-nine percent of pacemakers implanted in the United States include an option for rate modulation. OBJECTIVE: The purpose of this study was to determine whether dual-chamber rate-modulated pacing, when compared with dual-chamber pacing alo ... Full text Link to item Cite

Effect of exercise training on ventricular function, dyssynchrony, resting myocardial perfusion, and clinical outcomes in patients with heart failure: a nuclear ancillary study of Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION); design and rationale.

Journal Article Am Heart J · July 2007 BACKGROUND: Technetium Tc 99m gated single photon emission computed tomography (SPECT) has become the cornerstone of noninvasive risk stratification in patients with ischemic heart disease, but its role in patients with heart failure is not as well establi ... Full text Link to item Cite

Designation and distribution of events in the Multicenter UnSustained Tachycardia Trial (MUSTT).

Journal Article Am J Cardiol · July 1, 2007 Patients with coronary artery disease, depressed left ventricular ejection fraction, and nonsustained ventricular tachycardia (VT) have a high mortality rate due to arrhythmic (arrhythmic death/cardiac arrest) and other cardiac causes. The Multicenter UnSu ... Full text Link to item Cite

Preventing tomorrow's sudden cardiac death today: part I: Current data on risk stratification for sudden cardiac death.

Journal Article Am Heart J · June 2007 Accurate and timely prediction of sudden cardiac death (SCD) is a necessary prerequisite for effective prevention and therapy. Although the largest number of SCD events occurs in patients without overt heart disease, there are currently no tests that are o ... Full text Link to item Cite

Where patients with mild to moderate heart failure die: results from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article Am Heart J · June 2007 BACKGROUND: Common locations of death in patients with congestive heart failure (CHF) are unknown. In the SCD-HeFT, mortality of patients with CHF was assessed after randomization to an implantable cardioverter/defibrillator (ICD), amiodarone, or placebo. ... Full text Link to item Cite

Preventing tomorrow's sudden cardiac death today: part II: Translating sudden cardiac death risk assessment strategies into practice and policy.

Journal Article Am Heart J · June 2007 Although current evidence supporting a more precise strategy for identifying patients at highest risk for sudden cardiac death (SCD) is sparse, strategies for translating existing and future evidence into clinical practice and policy are needed today. A gr ... Full text Link to item Cite

Risk of thromboembolism in heart failure: an analysis from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article Circulation · May 22, 2007 BACKGROUND: In patients with heart failure, rates of clinically apparent stroke range from 1.3% to 3.5% per year. Little is known about the incidence and risk factors in the absence of atrial fibrillation. In the Sudden Cardiac Death in Heart Failure Trial ... Full text Link to item Cite

Absence of bilateral vision loss from amiodarone: a randomized trial.

Journal Article Am Heart J · May 2007 BACKGROUND: Amiodarone's role as a cause of toxic optic neuropathy is based on case reports. Annual frequency estimates of 0.36% to 2.0%, which have been made without reference to the dose or duration of treatment, are 12 to 200 times higher than those for ... Full text Link to item Cite

Statin use was associated with reduced mortality in both ischemic and nonischemic cardiomyopathy and in patients with implantable defibrillators: mortality data and mechanistic insights from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article Am Heart J · April 2007 BACKGROUND: Recent observations suggest statin treatment may be associated with lower mortality in heart failure (HF). The SCD-HeFT was a study of 2521 functional class II and III HF patients with left ventricular ejection fractions < or = 35% and ischemic ... Full text Link to item Cite

Implantable cardioverter defibrillator therapy improves the survival of patients with prior coronary revascularization: Data from the sudden cardiac death in heart failure trial

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 6, 2007 Link to item Cite

Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale.

Journal Article Am Heart J · February 2007 BACKGROUND: Although there are limited clinical data to support the use of exercise training as a means to reduce mortality and morbidity in patients with heart failure, current guidelines state that exercise is beneficial. TRIAL DESIGN: The objective of t ... Full text Link to item Cite

Role of amiodarone or implantable cardioverter/defibrillator in patients with atrial fibrillation and heart failure.

Journal Article Am Heart J · November 2006 BACKGROUND: Heart failure complicated by atrial fibrillation (AF) is associated with excessive mortality and morbidity. The aim of the study was to determine the role of amiodarone or implantable cardioverter/defibrillator (ICD) in patients with AF and hea ... Full text Link to item Cite

Thyroid function and mortality in the sudden cardiac death in heart failure trial

Conference CIRCULATION · October 31, 2006 Link to item Cite

Selection of surgical or percutaneous coronary intervention provides differential longevity benefit.

Journal Article Ann Thorac Surg · October 2006 BACKGROUND: Treatment of coronary artery disease (CAD) is evolving with better medications, improvements in percutaneous coronary intervention (PCI), and enhanced techniques for coronary artery bypass grafting (CABG). METHODS: In this study, 18,481 patient ... Full text Link to item Cite

Cost-effectiveness of defibrillator therapy or amiodarone in chronic stable heart failure: results from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article Circulation · July 11, 2006 BACKGROUND: In the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT), implantable cardioverter-defibrillator (ICD) therapy significantly reduced all-cause mortality rates compared with medical therapy alone in patients with stable, moderately symptoma ... Full text Link to item Cite

Cardiovascular outcomes with atrial-based pacing compared with ventricular pacing: meta-analysis of randomized trials, using individual patient data.

Journal Article Circulation · July 4, 2006 BACKGROUND: Several randomized trials have compared atrial-based (dual-chamber or atrial) pacing with ventricular pacing in patients with bradycardia. No trial has shown a mortality reduction, and only 1 small trial suggested a reduction in stroke. The goa ... Full text Link to item Cite

Treatment crossovers did not affect randomized treatment comparisons in the Mode Selection Trial (MOST).

Journal Article J Am Coll Cardiol · June 6, 2006 OBJECTIVES: We evaluated the impact of treatment crossovers on study results in the Mode Selection Trial (MOST). BACKGROUND: The MOST study, a 2,010-patient, 6-year trial comparing dual-chamber pacing (DDDR) and ventricular pacing (VVIR) in sinus node dysf ... Full text Link to item Cite

Comparing classifications of death in the Mode Selection Trial: agreement and disagreement among site investigators and a clinical events committee.

Journal Article Contemp Clin Trials · June 2006 Clinical events committees (CECs) are the current standard for endpoint adjudication in clinical trials. However, little data exist with which to compare CEC and site investigator determinations or to evaluate internal agreement among CEC members. Using da ... Full text Link to item Cite

Pacemaker implantation and quality of life in the Mode Selection Trial (MOST).

Journal Article Heart Rhythm · June 2006 BACKGROUND: Dual-chamber pacemakers restore AV synchrony compared with ventricular pacemakers, but the effects on health-related quality of life (QOL) are uncertain. OBJECTIVES: The purpose of this study was to assess the effect of pacemaker implantation, ... Full text Link to item Cite

From efficacy to safety concerns: a STEP forward or a step back for clinical research and intercessory prayer? The Study of Therapeutic Effects of Intercessory Prayer (STEP).

Journal Article Am Heart J · April 2006 Full text Link to item Cite

The association of the heart failure score with mortality and heart failure hospitalizations in elderly patients: insights from the Mode Selection Trial (MOST).

Journal Article Am Heart J · March 2006 BACKGROUND: Patient and physician preferences as well as cost favor an increasingly higher threshold for hospital admission for heart failure (HF) treatment. This trend risks masking the severity and prevalence of HF as hospitalization for HF may decrease. ... Full text Link to item Cite

The MANTRA II study.

Journal Article Lancet · November 19, 2005 Full text Link to item Cite

A new anatomic score for prognosis after cardiac catheterization in patients with previous bypass surgery.

Journal Article J Am Coll Cardiol · November 1, 2005 OBJECTIVES: The purpose of this study was to determine the value of a new anatomic score for prognosis after diagnostic catheterization in patients with previous coronary artery bypass grafting (CABG). BACKGROUND: Previous CABG patients comprise a growing ... Full text Link to item Cite

The PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) trial: study rationale, design, and baseline patient characteristics.

Journal Article Am Heart J · October 2005 BACKGROUND: Coronary artery bypass graft (CABG) surgery with autologous vein graft (VG) conduit is one of the most frequently performed operations in the United States. Unfortunately, many VGs become occluded during long-term follow-up largely because of n ... Full text Link to item Cite

Prognostic/Clinical Prediction Models: Using Observational Data to Estimate Prognosis: An Example Using a Coronary Artery Disease Registry

Chapter · August 24, 2005 With the proliferation of clinical data registries and the rising expense of clinical trials, observational data sources are increasingly providing evidence for clinical decision making. These data are viewed as complementary to randomized clinical trials ... Full text Cite

Prognostic/Clinical Prediction Models: Multivariable Prognostic Models: Issues in Developing Models, Evaluating Assumptions and Adequacy, and Measuring and Reducing Errors

Chapter · August 24, 2005 Multivariable regression models are powerful tools that are used frequently in studies of clinical outcomes. These models can use a mixture of categorical and continuous variables and can handle partially observed (censored) responses. However, uncritical ... Full text Cite

Clinical and quality of life comparison of accelerometer, piezoelectric crystal, and blended sensors in DDDR-paced patients with sinus node dysfunction in the mode selection trial (MOST).

Journal Article Pacing Clin Electrophysiol · August 2005 INTRODUCTION: Permanent pacemakers are capable of increasing heart rate in response to physical activity by a variety of sensors including accelerometers, piezoelectric crystals, or blended sensors. The impact of these different physiologic sensors on card ... Full text Link to item Cite

Music, imagery, touch, and prayer as adjuncts to interventional cardiac care: the Monitoring and Actualisation of Noetic Trainings (MANTRA) II randomised study.

Journal Article Lancet · July 16, 2005 BACKGROUND: Data from a pilot study suggested that noetic therapies-healing practices that are not mediated by tangible elements-can reduce preprocedural distress and might affect outcomes in patients undergoing percutaneous coronary intervention. We under ... Full text Link to item Cite

Implantable cardioverter defibrillators and cardiac resynchronization therapy in patients with left ventricular dysfunction: randomized trial evidence through 2004.

Journal Article Am Heart J · June 2005 Although many studies have shown that implantable cardioverter defibrillator (ICD) therapy improves the survival of patients with significant left ventricular dysfunction, the magnitude of effectiveness of ICD therapy in clinically defined subgroups remain ... Full text Link to item Cite

Association of prolonged QRS duration with death in a clinical trial of pacemaker therapy for sinus node dysfunction.

Journal Article Circulation · May 17, 2005 BACKGROUND: Prolonged QRS duration (QRSd) is an important prognostic indicator for death and heart failure hospitalization in patients with systolic heart failure. The relationship of baseline QRSd to death and heart failure hospitalization in patients wit ... Full text Link to item Cite

Implantable cardioverter-defibrillators.

Journal Article N Engl J Med · May 12, 2005 Link to item Cite

Heart failure hospitalization is more common in pacemaker patients with sinus node dysfunction and a prolonged paced QRS duration.

Journal Article Heart Rhythm · March 2005 OBJECTIVES: The purpose of this study was to determine whether a prolonged paced QRS duration increases the risk of cardiac dysfunction. BACKGROUND: Right ventricular apical pacing mimics left bundle branch block, results in a prolonged QRS duration of var ... Full text Link to item Cite

Thrombolysis and counterpulsation to improve survival in myocardial infarction complicated by hypotension and suspected cardiogenic shock or heart failure: results of the TACTICS Trial.

Journal Article J Thromb Thrombolysis · February 2005 BACKGROUND: Sustained hypotension, cardiogenic shock, and heart failure all imply a poor prognosis in acute myocardial infarction (MI). We assessed the benefit of adding 48 hours of intra-aortic balloon counterpulsation (IABP) to standard treatment for MI, ... Full text Link to item Cite

Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure.

Journal Article N Engl J Med · January 20, 2005 BACKGROUND: Sudden death from cardiac causes remains a leading cause of death among patients with congestive heart failure (CHF). Treatment with amiodarone or an implantable cardioverter-defibrillator (ICD) has been proposed to improve the prognosis in suc ... Full text Link to item Cite

Cost-effectiveness of dual-chamber pacing compared with ventricular pacing for sinus node dysfunction.

Journal Article Circulation · January 18, 2005 BACKGROUND: Compared with single-chamber ventricular pacing, dual-chamber pacing can reduce adverse events and, as a result, improve quality of life in patients paced for sick sinus syndrome. It is not clear, however, how these benefits compare with the in ... Full text Link to item Cite

Lessons learned from a clinical trial.

Journal Article Circulation · December 7, 2004 Full text Link to item Cite

Long-term mortality of patients with acute myocardial infarction in the United States and Canada: comparison of patients enrolled in Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO)-I.

Journal Article Circulation · September 28, 2004 BACKGROUND: In a previous substudy of the GUSTO-I trial, we observed better functional and quality-of-life outcomes among patients in the United States (US patients) compared with patients in Canada. Rates of invasive therapy were significantly higher in t ... Full text Link to item Cite

Is rhythm control superior to rate control in patients with atrial fibrillation and congestive heart failure?

Journal Article Am J Cardiol · September 15, 2004 In 1,009 patients with atrial fibrillation and congestive heart failure, the 2-year mortality rate was 31% in patients treated with rate control (n = 505) versus 29% in patients treated with rhythm control (n = 504). After adjusting for differences in base ... Full text Link to item Cite

Influence of gender on arrhythmia characteristics and outcome in the Multicenter UnSustained Tachycardia Trial.

Journal Article J Cardiovasc Electrophysiol · September 2004 INTRODUCTION: Previous studies have demonstrated gender differences in risk of sudden death in patients with ischemic heart disease. The Multicenter UnSustained Tachycardia Trial (MUSTT) evaluated the ability of therapy guided by electrophysiologic (EP) te ... Full text Link to item Cite

Electrocardiographic predictors of arrhythmic death and total mortality in the multicenter unsustained tachycardia trial.

Journal Article Circulation · August 17, 2004 BACKGROUND: Stratifiers of sudden and total mortality risk are needed to optimally target preventive therapies in patients with coronary artery disease and impaired ventricular function. We assessed the prognostic significance of ECG markers of conduction ... Full text Link to item Cite

High incidence of pacemaker syndrome in patients with sinus node dysfunction treated with ventricular-based pacing in the Mode Selection Trial (MOST).

Journal Article J Am Coll Cardiol · June 2, 2004 OBJECTIVES: We evaluated the incidence, predictors, and treatment of pacemaker syndrome in patients with sinus node dysfunction treated with ventricular-based (VVIR) pacing in the Mode Selection Trial (MOST). BACKGROUND: Pacemaker syndrome, or intolerance ... Full text Link to item Cite

Predictors of stroke in patients paced for sick sinus syndrome.

Journal Article J Am Coll Cardiol · May 5, 2004 OBJECTIVES: This study was an analysis of factors associated with stroke in a population of patients paced for sinus node dysfunction in a large prospective clinical trial (Mode Selection Trial [MOST]). BACKGROUND: The effects of dual-chamber versus single ... Full text Link to item Cite

1056-163 Duke viability index predicts long-term mortality in patients with ischemic cardiomyopathy independent of treatment allocation

Conference Journal of the American College of Cardiology · March 2004 Full text Cite

Risk factors for intracranial hemorrhage and nonhemorrhagic stroke after fibrinolytic therapy (from the GUSTO-i trial).

Journal Article Am J Cardiol · February 15, 2004 Of 592 patients in the Global Utilization of Streptokinase and tPA for Occluded Arteries-I trial who had a stroke during initial hospitalization, the risk for intracranial hemorrhage was significantly greater in those with recent facial or head trauma (odd ... Full text Link to item Cite

Prospective randomized study of mode switching in a clinical trial of pacemaker therapy for sinus node dysfunction.

Journal Article J Cardiovasc Electrophysiol · February 2004 INTRODUCTION: Atrial fibrillation (AF) is common in pacemaker patients with sinus node dysfunction (SND) and may result in rapid ventricular pacing (RVP) in the DDDR mode. Mode switching (MS) reduces RVP, but its clinical benefit in patients with SND is un ... Full text Link to item Cite

Acute Coronary Syndrome patients in New Zealand receive less invasive management when admitted to hospitals without invasive facilities

Journal Article New Zealand Medical Journal · 2004 Aim: To compare differences in the presentation and management of acute coronary syndrome (ACS) patients presenting to interventional versus non-interventional New Zealand hospitals. Methods: We assessed the data collected by the New Zealand Cardiac Societ ... Cite

International variation in the use of evidence-based medicines for acute coronary syndromes.

Journal Article Eur Heart J · December 2003 AIMS: We sought to evaluate international patterns of use and factors influencing use of evidence-based medications early after ACS. METHODS AND RESULTS: Using a database of 15904 ACS patients enrolled in the SYMPHONY and 2nd SYMPHONY trials in 37 countrie ... Full text Link to item Cite

Death in patients with permanent pacemakers for sick sinus syndrome.

Journal Article Am Heart J · November 2003 BACKGROUND: Although more than one million patients in the United States have permanent pacemakers, little is known about their cause of death. We evaluated the cause of death in 404 patients who died in the Mode Selection Trial (MOST). METHODS: In MOST, p ... Full text Link to item Cite

Complications arising after implantation of DDD pacemakers: the MOST experience.

Journal Article Am J Cardiol · September 15, 2003 The purpose of this study was to characterize the incidence, time course, frequency, and spectrum of acute and chronic complications arising from dual-chamber pacemaker implantation. This information may serve as a benchmark when comparing complication rat ... Full text Link to item Cite

Racial differences in outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT): a comparison of whites versus blacks.

Journal Article Circulation · July 8, 2003 BACKGROUND: The Multicenter UnSustained Tachycardia Trial (MUSTT) demonstrated the benefit of implantable cardioverter-defibrillators (ICDs) in patients with coronary disease, asymptomatic nonsustained ventricular tachycardia, and reduced left ventricular ... Full text Link to item Cite

Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction.

Journal Article Circulation · June 17, 2003 BACKGROUND: Dual-chamber (DDDR) pacing preserves AV synchrony and may reduce heart failure (HF) and atrial fibrillation (AF) compared with ventricular (VVIR) pacing in sinus node dysfunction (SND). However, DDDR pacing often results in prolonged QRS durati ... Full text Link to item Cite

Atrial high rate episodes detected by pacemaker diagnostics predict death and stroke: report of the Atrial Diagnostics Ancillary Study of the MOde Selection Trial (MOST).

Journal Article Circulation · April 1, 2003 BACKGROUND: Some current pacing systems can automatically detect and record atrial tachyarrhythmias that may be asymptomatic. We prospectively studied a 312-patient (pt) subgroup of MOST (MOde Selection Trial), a 2010-patient, 6-year randomized trial of DD ... Full text Link to item Cite

Sustained ventricular arrhythmias and mortality among patients with acute myocardial infarction: results from the GUSTO-III trial.

Journal Article Am Heart J · March 2003 BACKGROUND: In many patients, ventricular arrhythmias will develop early after acute myocardial infarction. We studied the incidence, timing, and outcomes of such arrhythmias in the international Global Utilization of Streptokinase and TPA (alteplase) for ... Full text Link to item Cite

Cardiac pacing for sinus-node dysfunction.

Journal Article N Engl J Med · December 5, 2002 Full text Link to item Cite

Effect of beta-blocking therapy on outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT).

Journal Article Circulation · November 19, 2002 BACKGROUND: Beta-blockers are known to reduce total mortality and sudden death in survivors of recent myocardial infarction. The effects of these agents in patients at high risk for sudden death with remote infarction are not clear. METHODS AND RESULTS: We ... Full text Link to item Cite

Relation of ejection fraction and inducible ventricular tachycardia to mode of death in patients with coronary artery disease: an analysis of patients enrolled in the multicenter unsustained tachycardia trial.

Journal Article Circulation · November 5, 2002 BACKGROUND: Fifty percent of deaths in patients with coronary disease occur suddenly. Although many factors correlate with increased mortality, there is little information regarding the influence of these factors on mode of death. As such, optimum methods ... Full text Link to item Cite

Prognostic significance of nonsustained ventricular tachycardia identified postoperatively after coronary artery bypass surgery in patients with left ventricular dysfunction.

Journal Article J Cardiovasc Electrophysiol · August 2002 INTRODUCTION: Nonsustained ventricular tachycardia (NSVT) occurs frequently in the postoperative period (< or = 30 days) after coronary artery bypass graft (CABG) surgery, a setting where many factors may play a role in its genesis. The prognosis of NSVT i ... Full text Link to item Cite

Sustained ventricular arrhythmias among patients with acute coronary syndromes with no ST-segment elevation: incidence, predictors, and outcomes.

Journal Article Circulation · July 16, 2002 BACKGROUND: The prognosis of ventricular arrhythmias among patients with non-ST-elevation acute coronary syndromes is unknown. We studied the incidence, predictors, and outcomes of sustained ventricular arrhythmias in 4 large randomized trials of such pati ... Full text Link to item Cite

Comparison of coronary artery bypass grafting versus medical therapy on long-term outcome in patients with ischemic cardiomyopathy (a 25-year experience from the Duke Cardiovascular Disease Databank).

Journal Article Am J Cardiol · July 15, 2002 In this observational treatment comparison in a single center over 25 years, we sought to assess long-term outcomes of coronary artery bypass surgery (CABG) or medical therapy in patients with heart failure, coronary artery disease, and left ventricular sy ... Full text Link to item Cite

Effect of implantable defibrillators on arrhythmic events and mortality in the multicenter unsustained tachycardia trial.

Journal Article Circulation · July 9, 2002 BACKGROUND: The Multicenter Unsustained Tachycardia Trial (MUSTT) was designed to evaluate an antiarrhythmic treatment strategy, including drugs and implantable defibrillators (ICDs), guided by electrophysiological (EP) testing. We performed several statis ... Full text Link to item Cite

Biphasic versus monophasic shock waveform for conversion of atrial fibrillation: the results of an international randomized, double-blind multicenter trial.

Journal Article J Am Coll Cardiol · June 19, 2002 OBJECTIVES: This study compared a biphasic waveform with a conventional monophasic waveform for cardioversion of atrial fibrillation (AF). BACKGROUND: Biphasic shock waveforms have been demonstrated to be superior to monophasic shocks for termination of ve ... Full text Link to item Cite

Ventricular pacing or dual-chamber pacing for sinus-node dysfunction.

Journal Article N Engl J Med · June 13, 2002 BACKGROUND: Dual-chamber (atrioventricular) and single-chamber (ventricular) pacing are alternative treatment approaches for sinus-node dysfunction that causes clinically significant bradycardia. However, it is unknown which type of pacing results in the b ... Full text Link to item Cite

Misreporting of myocardial infarction end points: results of adjudication by a central clinical events committee in the PARAGON-B trial. Second Platelet IIb/IIIa Antagonist for the Reduction of Acute Coronary Syndrome Events in a Global Organization Network Trial.

Journal Article Am Heart J · February 2002 BACKGROUND: Myocardial (re)infarction (MI), a common trial end point, can be difficult to identify because of inconclusive signs and symptoms. We examined disagreement between investigator and clinical events committee (CEC) reporting of MIs in an internat ... Full text Link to item Cite

The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery.

Other Anesth Analg · January 2002 UNLABELLED: Neurocognitive dysfunction is a common complication after cardiac surgery. We evaluated in this prospective study the effect of rewarming rate on neurocognitive outcome after hypothermic cardiopulmonary bypass (CPB). After IRB approval and info ... Full text Link to item Cite

Differences in inducibility and prognosis of in-hospital versus out-of-hospital identified nonsustained ventricular tachycardia in patients with coronary artery disease: clinical and trial design implications.

Journal Article J Am Coll Cardiol · October 2001 OBJECTIVES: The goal of this study was to describe the influence of the clinical setting (in-hospital vs. out-of-hospital) in which nonsustained ventricular tachycardia (NSVT) is discovered on the rate of inducibility of sustained ventricular tachycardia ( ... Full text Link to item Cite

Using observational data to estimate prognosis: an example using a coronary artery disease registry.

Journal Article Stat Med · August 30, 2001 With the proliferation of clinical data registries and the rising expense of clinical trials, observational data sources are increasingly providing evidence for clinical decision making. These data are viewed as complementary to randomized clinical trials ... Full text Link to item Cite

Prediction of long-term outcomes by signal-averaged electrocardiography in patients with unsustained ventricular tachycardia, coronary artery disease, and left ventricular dysfunction.

Journal Article Circulation · July 24, 2001 BACKGROUND: An abnormal signal-averaged ECG (SAECG) is a noninvasive marker of the substrate of sustained ventricular tachycardia after myocardial infarction. We assessed its prognostic ability in patients with asymptomatic unsustained ventricular tachycar ... Full text Link to item Cite

Systematic adjudication of myocardial infarction end-points in an international clinical trial.

Journal Article Curr Control Trials Cardiovasc Med · July 17, 2001 BACKGROUND: Clinical events committees (CEC) are used routinely to adjudicate suspected end-points in cardiovascular trials, but little information has been published about the various processes used. We reviewed results of the CEC process used to identify ... Full text Link to item Cite

Disagreements between central clinical events committee and site investigator assessments of myocardial infarction endpoints in an international clinical trial: review of the PURSUIT study.

Journal Article Curr Control Trials Cardiovasc Med · July 17, 2001 BACKGROUND: Limited information has been published regarding how specific processes for event adjudication can affect event rates in trials. We reviewed nonfatal myocardial infarctions (MIs) reported by site investigators in the international Platelet Glyc ... Full text Link to item Cite

Atrial fibrillation and mortality among patients with acute coronary syndromes without ST-segment elevation: results from the PURSUIT trial.

Journal Article Am J Cardiol · July 1, 2001 Full text Link to item Cite

Electrophysiologic and clinical effects of angiotensin-converting enzyme inhibitors in patients with prior myocardial infarction, nonsustained ventricular tachycardia, and depressed left ventricular function. MUSTT Investigators. Multicenter UnSustained Tachycardia Trial.

Journal Article Am J Cardiol · March 15, 2001 Angiotensin-converting enzyme (ACE) inhibitors have been shown to reduce sudden cardiac death and all-cause mortality. They also may have direct antiarrhythmic properties. We retrospectively analyzed the data from the Multicenter UnSustained Tachycardia Tr ... Full text Link to item Cite

Data and safety monitoring committees: philosophy and practice.

Journal Article Am Heart J · January 2001 Full text Link to item Cite

Electrophysiologic testing to identify patients at risk for sudden death.

Journal Article N Engl J Med · December 14, 2000 Full text Link to item Cite

Randomisation in the SYMPHONY trial.

Journal Article Lancet · October 28, 2000 Full text Link to item Cite

The mode selection trial (MOST) in sinus node dysfunction: design, rationale, and baseline characteristics of the first 1000 patients.

Journal Article Am Heart J · October 2000 BACKGROUND: More than 200,000 permanent pacemakers will be implanted in the United States in 2000 at a cost of more than $2 billion. Sick sinus syndrome (SSS) will likely account for approximately half of all cases necessitating implantation. Pacemaker tec ... Full text Link to item Cite

Risk stratification and therapeutic decision making in acute coronary syndromes.

Journal Article JAMA · August 16, 2000 Full text Link to item Cite

Electrophysiologic testing to identify patients with coronary artery disease who are at risk for sudden death. Multicenter Unsustained Tachycardia Trial Investigators.

Journal Article N Engl J Med · June 29, 2000 BACKGROUND: The mortality rate among patients with coronary artery disease, abnormal ventricular function, and unsustained ventricular tachycardia is high. The usefulness of electrophysiologic testing for risk stratification in these patients is unclear. M ... Full text Link to item Cite

Predictors of outcome in patients with acute coronary syndromes without persistent ST-segment elevation. Results from an international trial of 9461 patients. The PURSUIT Investigators.

Journal Article Circulation · June 6, 2000 BACKGROUND: Appropriate treatment policies should include an accurate estimate of a patient's baseline risk. Risk modeling to date has been underutilized in patients with acute coronary syndromes without persistent ST-segment elevation. METHODS AND RESULTS ... Full text Link to item Cite

Prediction of 1-year survival after thrombolysis for acute myocardial infarction in the global utilization of streptokinase and TPA for occluded coronary arteries trial.

Journal Article Circulation · May 16, 2000 BACKGROUND: When a patient survives thrombolysis for acute myocardial infarction, little information from large studies exists from which to estimate prognosis during follow-up visits. METHODS AND RESULTS: Baseline, in-hospital, and later survival data wer ... Full text Link to item Cite

Clinical trials in acute myocardial infarction: should we adjust for baseline characteristics?

Journal Article Am Heart J · May 2000 BACKGROUND: Clinical trials concerning acute myocardial infarction often evaluate short-term death. Several baseline characteristics are predictors of death, most notably age. Adjustment for one or more predictors in a multivariable analysis may be conside ... Full text Link to item Cite

Prevention of sudden death in patients with coronary artery disease.

Journal Article N Engl J Med · April 27, 2000 Link to item Cite

Sample size and interim analysis issues for dose selection.

Journal Article Am Heart J · April 2000 Full text Link to item Cite

Prognostic models based on literature and individual patient data in logistic regression analysis.

Journal Article Stat Med · January 30, 2000 Prognostic models can be developed with multiple regression analysis of a data set containing individual patient data. Often this data set is relatively small, while previously published studies present results for larger numbers of patients. We describe a ... Full text Link to item Cite

A randomized study of the prevention of sudden death in patients with coronary artery disease. Multicenter Unsustained Tachycardia Trial Investigators.

Journal Article N Engl J Med · December 16, 1999 BACKGROUND: Empirical antiarrhythmic therapy has not reduced mortality among patients with coronary artery disease and asymptomatic ventricular arrhythmias. Previous studies have suggested that antiarrhythmic therapy guided by electrophysiologic testing mi ... Full text Link to item Cite

Prediction of sustained ventricular tachycardia inducible by programmed stimulation in patients with coronary artery disease. Utility of clinical variables.

Journal Article Circulation · April 13, 1999 BACKGROUND: Cardiologists often use clinical variables to determine the need for electrophysiological studies to stratify patients for risk of sudden death. It is not clear whether this is rational in patients with coronary artery disease, left ventricular ... Full text Link to item Cite

Value of serial troponin T measures for early and late risk stratification in patients with acute coronary syndromes. The GUSTO-IIa Investigators.

Journal Article Circulation · November 3, 1998 BACKGROUND: The baseline cardiac troponin T (cTnT) level strongly predicts short-term mortality in acute coronary syndromes, but the added value of later measures to predict short- and long-term outcome and in the context of baseline clinical characteristi ... Full text Link to item Cite

Acute coronary syndromes in the GUSTO-IIb trial: prognostic insights and impact of recurrent ischemia. The GUSTO-IIb Investigators.

Journal Article Circulation · November 3, 1998 BACKGROUND: Recurrent ischemia after an acute coronary syndrome portends an unfavorable outcome and has major resource-use implications. This issue has not been studied systematically among the spectrum of patients with acute coronary presentations, encomp ... Full text Link to item Cite

Atenolol use and clinical outcomes after thrombolysis for acute myocardial infarction: the GUSTO-I experience. Global Utilization of Streptokinase and TPA (alteplase) for Occluded Coronary Arteries.

Journal Article J Am Coll Cardiol · September 1998 OBJECTIVES: We assessed the use and effects of acute intravenous and later oral atenolol treatment in a prospectively planned post hoc analysis of the GUSTO-I dataset. BACKGROUND: Early intravenous beta blockade is generally recommended after myocardial in ... Full text Link to item Cite

International, randomized, controlled trial of lamifiban (a platelet glycoprotein IIb/IIIa inhibitor), heparin, or both in unstable angina. The PARAGON Investigators. Platelet IIb/IIIa Antagonism for the Reduction of Acute coronary syndrome events in a Global Organization Network.

Journal Article Circulation · June 23, 1998 BACKGROUND: Unstable angina and non-Q-wave myocardial infarction involve coronary arterial plaque rupture, platelet activation, and thrombus formation. This study tested the benefit of different doses of lamifiban (a platelet IIb/IIIa antagonist) alone and ... Full text Link to item Cite

Higher T-wave amplitude associated with better prognosis in patients receiving thrombolytic therapy for acute myocardial infarction (a GUSTO-I substudy). Global Utilization of Streptokinase and Tissue plasminogen Activator for Occluded Coronary Arteries.

Journal Article Am J Cardiol · May 1, 1998 Increased T-wave amplitude is one of the earliest electrocardiographic (ECG) changes following coronary artery occlusion. Therefore, higher T waves in the presenting electrocardiogram should represent earlier time to treatment and thus be associated with l ... Full text Link to item Cite

A randomized trial of vascular hemostasis techniques to reduce femoral vascular complications after coronary intervention.

Journal Article Am J Cardiol · April 15, 1998 This report details a prospectively randomized clinical trial comparing mechanical clamp compression to hand applied pressure for attaining vascular hemostasis after coronary intervention. Effectiveness was determined by comparing the incidence of femoral ... Full text Link to item Cite

A comparison of reteplase with alteplase for acute myocardial infarction.

Journal Article N Engl J Med · October 16, 1997 BACKGROUND: Reteplase (recombinant plasminogen activator), a mutant of alteplase tissue plasminogen activator, has a longer half-life than its parent molecule and produced superior angiographic results in pilot studies of acute myocardial infarction. In th ... Full text Link to item Cite

Patient-specific predictions of outcomes in myocardial infarction for real-time emergency use: a thrombolytic predictive instrument.

Journal Article Ann Intern Med · October 1, 1997 BACKGROUND: Thrombolytic therapy can be life-saving in patients with acute myocardial infarction. However, if given too late or insufficiently selectively, it may provide little benefit but still cause serious complications and incur substantial costs. OBJ ... Full text Link to item Cite

Clinical determinants of mortality in patients with angiographically diagnosed ischemic or nonischemic cardiomyopathy.

Journal Article J Am Coll Cardiol · October 1997 OBJECTIVES: We sought to characterize the clinical determinants of mortality in patients with angiographically diagnosed ischemic or nonischemic cardiomyopathy. BACKGROUND: Patients with ischemic cardiomyopathy may have a worse prognosis than patients with ... Full text Link to item Cite

A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction.

Journal Article N Engl J Med · June 5, 1997 BACKGROUND: Among physicians who treat patients with acute myocardial infarction, there is controversy about the magnitude of the clinical benefit of primary (i.e., immediate) coronary angioplasty as compared with thrombolytic therapy. METHODS: As part of ... Full text Link to item Cite

Incidence and predictors of bleeding after contemporary thrombolytic therapy for myocardial infarction. The Global Utilization of Streptokinase and Tissue Plasminogen activator for Occluded coronary arteries (GUSTO) I Investigators.

Journal Article Circulation · June 3, 1997 BACKGROUND: Although the benefit of thrombolytic therapy in reducing mortality in acute myocardial infarction is well established, the types of bleeding and risk factors for bleeding are less well described in large trials. METHODS AND RESULTS: We analyzed ... Full text Link to item Cite

Selection of thrombolytic therapy for individual patients: development of a clinical model. GUSTO-I Investigators.

Journal Article Am Heart J · June 1997 We developed a logistic regression model with data from the GUSTO-I trial to predict mortality rate differences in individual patients who received accelerated tissue plasminogen activator (TPA) versus streptokinase treatment for acute myocardial infarctio ... Full text Link to item Cite

Incidence and impact on outcome of streptokinase allergy in the GUSTO-I trial. Global Utilization of Streptokinase and t-PA in Occluded Coronary Arteries.

Journal Article Am J Cardiol · May 1, 1997 We evaluated allergic reactions in 20,201 patients randomized to the streptokinase arms of The Global Utilization of Streptokinase and t-PA (Tissue Plasminogen Activator) in Occluded Coronary Arteries (GUSTO-I) trial, and tested the hypothesis that patient ... Full text Link to item Cite

Predictors of outcome of reperfusion therapy.

Journal Article Eur Heart J · May 1997 The physician wishing to estimate the risk of death for a patient experiencing acute myocardial infarction can rapidly use parameters available on first seeing the patient to estimate the expected mortality and can update this risk during the early phase o ... Full text Link to item Cite

Perspectives on large-scale cardiovascular clinical trials for the new millennium. The Virtual Coordinating Center for Global Collaborative Cardiovascular Research (VIGOUR) Group.

Journal Article Circulation · February 18, 1997 Full text Link to item Cite

Coronary revascularization surgery after myocardial infarction: impact of bypass surgery on survival after thrombolysis. GUSTO Investigators. Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries.

Journal Article J Am Coll Cardiol · February 1997 OBJECTIVES: This study sought to investigate the impact of surgical revascularization on outcome after myocardial infarction. BACKGROUND: Small variations in rates of coronary artery bypass graft surgery (CABG) were noted among thrombolytic regimens in the ... Full text Link to item Cite

Admission prediction of expected final myocardial infarct size using weighted ST-segment, Q wave, and T wave measurements.

Journal Article J Electrocardiol · January 1997 Formulas for predicting final acute myocardial infarction (MI) size from ST-segment deviation on an initial electrocardiogram were proposed by Aldrich et al. for anterior and inferior infarct locations. This study of 529 patients who did not receive thromb ... Full text Link to item Cite

Age and outcome with contemporary thrombolytic therapy. Results from the GUSTO-I trial. Global Utilization of Streptokinase and TPA for Occluded coronary arteries trial.

Journal Article Circulation · October 15, 1996 BACKGROUND: Elderly patients with acute myocardial infarction have much to gain from reperfusion with thrombolytic therapy but are also at increased risk of adverse events. We examined outcomes according to age of patients receiving thrombolysis in an inte ... Full text Link to item Cite

One-year results from the Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries (GUSTO-I) trial. GUSTO-I Investigators.

Journal Article Circulation · September 15, 1996 BACKGROUND: In the randomized Global Utilization of t-PA and Streptokinase for Occluded Coronary Arteries (GUSTO-I) trial, 41021 patients received one of four thrombolytic regimens. Patients treated with accelerated tissue plasminogen activator (TPA) had a ... Full text Link to item Cite

Economic assessment of platelet glycoprotein IIb/IIIa inhibition for prevention of ischemic complications of high-risk coronary angioplasty. EPIC Investigators.

Journal Article Circulation · August 15, 1996 BACKGROUND: In the EPIC trial, c7E3 Fab, an antiplatelet IIb/ IIIa receptor antibody, reduced 30-day ischemic end points after high-risk coronary angioplasty by 35% and 6-month ischemic events by 23% but increased in-hospital bleeding episodes. METHODS AND ... Full text Link to item Cite

Nonsustained ventricular tachycardia in coronary artery disease: relation to inducible sustained ventricular tachycardia. MUSTT Investigators.

Journal Article Ann Intern Med · July 1, 1996 BACKGROUND: Many physicians believe that electrocardiographic characteristics of nonsustained ventricular tachycardia correlate with the risk for sudden death in survivors of myocardial infarction. Sustained ventricular tachycardia induced by programmed el ... Full text Link to item Cite

Time from symptom onset to treatment and outcomes after thrombolytic therapy. GUSTO-1 Investigators.

Journal Article J Am Coll Cardiol · June 1996 OBJECTIVES: This study sought to examine the relations among patient characteristics, time to thrombolysis and outcomes in the international GUSTO-I trial. BACKGROUND: Studies have shown better left ventricular function and decreased infarct size as well a ... Full text Link to item Cite

Activated partial thromboplastin time and outcome after thrombolytic therapy for acute myocardial infarction: results from the GUSTO-I trial.

Journal Article Circulation · March 1, 1996 BACKGROUND: Although intravenous heparin is commonly used after thrombolytic therapy, few reports have addressed the relationship between the degree of anticoagulation and clinical outcomes. We examined the activated partial thromboplastin time (aPTT) in 2 ... Full text Link to item Cite

Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors.

Journal Article Stat Med · February 28, 1996 Multivariable regression models are powerful tools that are used frequently in studies of clinical outcomes. These models can use a mixture of categorical and continuous variables and can handle partially observed (censored) responses. However, uncritical ... Full text Link to item Cite

Job strain and the prevalence and outcome of coronary artery disease.

Journal Article Circulation · August 1, 1995 BACKGROUND: It has been hypothesized that jobs that have both high psychological demands and low decision latitude ("job strain") can lead to coronary disease. The objective of this study was to test whether job strain was correlated with the presence of c ... Full text Link to item Cite

Importance of baseline functional and socioeconomic factors for participation in cardiac rehabilitation.

Journal Article Am J Cardiol · July 1, 1995 Enrollment in cardiac rehabilitation has been reported to improve exercise capacity, psychological well-being, and survival. However, participation rates are low and the reasons for nonparticipation have not been adequately defined. The purpose of this stu ... Full text Link to item Cite

Cost effectiveness of thrombolytic therapy with tissue plasminogen activator as compared with streptokinase for acute myocardial infarction.

Journal Article N Engl J Med · May 25, 1995 BACKGROUND: Patients with acute myocardial infarction who were treated with accelerated tissue plasminogen activator (t-PA) (given over a period of 1 1/2 hours rather than the conventional 3 hours, and with two thirds of the dose given in the first 30 minu ... Full text Link to item Cite

Variations in patient management and outcomes for acute myocardial infarction in the United States and other countries. Results from the GUSTO trial. Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries.

Journal Article JAMA · May 24, 1995 OBJECTIVE: To examine differences in outcomes and patient management between patients in the United States and outside the United States undergoing thrombolysis for acute myocardial infarction. DESIGN, SETTING, AND PATIENTS: Patients in the United States ( ... Full text Link to item Cite

Significance of a coronary artery with thrombolysis in myocardial infarction grade 2 flow "patency" (outcome in the thrombolysis and angioplasty in myocardial infarction trials). Thrombolysis and Angioplasty in Myocardial Infarction Study Group.

Journal Article Am J Cardiol · May 1, 1995 To determine whether pharmacologic reperfusion to Thrombolysis in Myocardial Infarction (TIMI) grade 2 flow during acute myocardial infarction confers the same clinical benefit as restoration of TIMI 3 flow, in-hospital clinical and angiographic outcomes i ... Full text Link to item Cite

A multicenter, randomized trial of coronary angioplasty versus directional atherectomy for patients with saphenous vein bypass graft lesions. CAVEAT-II Investigators.

Journal Article Circulation · April 1, 1995 BACKGROUND: Directional coronary atherectomy and percutaneous transluminal coronary angioplasty have both been used in symptomatic patients with coronary saphenous vein bypass graft stenoses. The relative merits of plaque excision and removal versus balloo ... Full text Link to item Cite

Predictors of 30-day mortality in the era of reperfusion for acute myocardial infarction. Results from an international trial of 41,021 patients. GUSTO-I Investigators.

Journal Article Circulation · March 15, 1995 BACKGROUND: Despite remarkable advances in the treatment of acute myocardial infarction, substantial early patient mortality remains. Appropriate choices among alternative therapies and the use of clinical resources depend on an estimate of the patient's r ... Full text Link to item Cite

Determining VA physician requirements through empirically based models.

Journal Article Health Serv Res · February 1995 OBJECTIVE: As part of a project to estimate physician requirements for the Department of Veterans Affairs, the Institute of Medicine (IOM) developed and tested empirically based models of physician staffing, by specialty, that could be applied to each VA f ... Link to item Cite

The exclusion of women from clinical trials of thrombolytic therapy: implications for developing the thrombolytic predictive instrument database.

Journal Article Med Decis Making · 1995 The thrombolytic predictive instrument (TPI) was developed to identify those patients most likely to benefit from thrombolytic therapy for acute myocardial infarction as well as to facilitate the earliest possible administration of this treatment. The TPI ... Full text Link to item Cite

Cerebral arteriovenous malformation

Journal Article New England Journal of Medicine · 1995 Full text Cite

Images in clinical medicine. Cerebral arteriovenous malformation.

Journal Article New England Journal of Medicine · 1995 Cite

Cardiovascular health and disease in women: Thrombolytic therapy for women with acute myocardial infarction: Is there a gender gap?

Journal Article Cardiovascular Reviews and Reports · January 1, 1995 Intravenous thrombolytic therapy has now been established as the standard approach for all eligible patients who present early with acute myocardial infarction. Relatively little clinical investigation however, has been addressed to the potential differenc ... Cite

More on the GUSTO Trial.

Journal Article Ann Intern Med · November 15, 1994 Full text Link to item Cite

Use of medical resources and quality of life after acute myocardial infarction in Canada and the United States.

Journal Article N Engl J Med · October 27, 1994 BACKGROUND: Much attention has been directed to the use of medical resources and to patients' outcomes in Canada as compared with the United States. We compared U.S. and Canadian patients with respect to their use of medical resources and their quality of ... Full text Link to item Cite

Presenting pulse pressure predicts thrombolytic therapy-related intracranial hemorrhage. Thrombolytic Predictive Instrument (TPI) Project results.

Journal Article Circulation · October 1994 BACKGROUND: In selecting patients with acute myocardial infarction for thrombolytic therapy, it is important to identify patients who are at high risk for intracranial hemorrhage, for whom thrombolytic therapy is ill advised. We hypothesized that presentin ... Full text Link to item Cite

Use of aortic counterpulsation to improve sustained coronary artery patency during acute myocardial infarction. Results of a randomized trial. The Randomized IABP Study Group.

Journal Article Circulation · August 1994 BACKGROUND: Aortic counterpulsation has been observed to reduce the rate of reocclusion of the infarct-related artery after patency has been restored during acute myocardial infarction in observational studies. To evaluate the benefit-to-risk ratio of aort ... Full text Link to item Cite

More on the GUSTO trial.

Journal Article N Engl J Med · July 28, 1994 Full text Link to item Cite

The last word on GUSTO, for now.

Journal Article Ann Intern Med · June 1, 1994 Full text Link to item Cite

Holding GUSTO up to the light. Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries.

Journal Article Ann Intern Med · May 15, 1994 The Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO) trial, a recent randomized "megatrial" of thrombolytic therapies in acute myocardial infarction, showed a statistically significant decrease of ... Full text Link to item Cite

Continuing evolution of therapy for coronary artery disease. Initial results from the era of coronary angioplasty.

Journal Article Circulation · May 1994 BACKGROUND: Survival after coronary artery bypass graft surgery (CABG) and medical therapy in patients with coronary artery disease (CAD) has been studied in both randomized trials and observational treatment comparisons. Over the past decade, the use of c ... Full text Link to item Cite

Randomised trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: results at six months. The EPIC Investigators.

Journal Article Lancet · April 9, 1994 Restenosis after coronary angioplasty occurs in at least 30% of patients in the first six months and, as yet, there is no known treatment to decrease this event. We tested a monoclonal antibody Fab fragment (c7E3) directed against the platelet glycoprotein ... Full text Link to item Cite

Clinical importance of thrombocytopenia occurring in the hospital phase after administration of thrombolytic therapy for acute myocardial infarction. The Thrombolysis and Angioplasty in Myocardial Infarction Study Group.

Journal Article J Am Coll Cardiol · March 15, 1994 OBJECTIVES: The purpose of this study was to examine the incidence and clinical implications of thrombocytopenia that occurs in hospital after administration of thrombolytic therapy for acute myocardial infarction. BACKGROUND: The use of thrombolytic thera ... Full text Link to item Cite

A randomized comparison of the effects of gradual prolonged versus standard primary balloon inflation on early and late outcome. Results of a multicenter clinical trial. Perfusion Balloon Catheter Study Group.

Journal Article Circulation · March 1994 BACKGROUND: Observational studies have suggested that prolonged balloon inflation during coronary angioplasty is associated with a high clinical success rate. This randomized clinical trial sought to evaluate the impact of primary gradual and prolonged inf ... Full text Link to item Cite

Effects of coronary angioplasty, coronary bypass surgery, and medical therapy on employment in patients with coronary artery disease. A prospective comparison study.

Journal Article Ann Intern Med · January 15, 1994 OBJECTIVE: To compare return-to-work rates after coronary angioplasty, coronary bypass surgery, and medical therapy in patients with coronary disease. DESIGN: Prospective cohort study. SETTING: Tertiary care referral center. PATIENTS: Between March 1986 an ... Full text Link to item Cite

From signal/noise to information content/noise. Reconsidering the statistical analysis of continuous ST-segment data streams with gaps: potential optimization of application-specific information content using left, right, and interval censoring.

Journal Article J Electrocardiol · 1994 Full text Link to item Cite

A randomized trial of intravenous heparin in conjunction with anistreplase (anisoylated plasminogen streptokinase activator complex) in acute myocardial infarction: the Duke University Clinical Cardiology Study (DUCCS) 1.

Journal Article J Am Coll Cardiol · January 1994 OBJECTIVES: We designed a randomized trial to evaluate the effects of heparin administration in conjunction with anistreplase (anisoylated plasminogen streptokinase activator complex [APSAC]) on arterial patency and clinical end points. BACKGROUND: The rol ... Full text Link to item Cite

Thrombolytic therapy for women with myocardial infarction: is there a gender gap? Thrombolysis and Angioplasty in Myocardial Infarction Study Group.

Journal Article J Am Coll Cardiol · December 1993 OBJECTIVES: The goal of this study was to investigate whether female gender portends an adverse prognosis independent of the severity of the underlying disease after acute myocardial infarction treated by thrombolysis. A total of 348 women were compared wi ... Full text Link to item Cite

The effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction.

Journal Article N Engl J Med · November 25, 1993 BACKGROUND: Although it is known that thrombolytic therapy improves survival after acute myocardial infarction, it has been debated whether the speed with which coronary-artery patency is restored after the initiation of therapy further affects outcome. ME ... Full text Link to item Cite

Noninvasive detection of reperfusion after thrombolysis based on serum creatine kinase MB changes and clinical variables. TAMI 7 Study Group. Thrombolysis and Angioplasty in Myocardial Infarction.

Journal Article Am Heart J · October 1993 Coronary artery patency after thrombolytic therapy has important prognostic implications for survival after acute myocardial infarction. The ability to noninvasively identify patients early after thrombolysis may therefore allow other strategies, such as a ... Full text Link to item Cite

An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction.

Journal Article N Engl J Med · September 2, 1993 BACKGROUND: The relative efficacy of streptokinase and tissue plasminogen activator and the roles of intravenous as compared with subcutaneous heparin as adjunctive therapy in acute myocardial infarction are unresolved questions. The current trial was desi ... Full text Link to item Cite

Continuous 12-lead ST-segment recovery analysis in the TAMI 7 study. Performance of a noninvasive method for real-time detection of failed myocardial reperfusion.

Journal Article Circulation · August 1993 BACKGROUND: If a practical, reliable, noninvasive marker of failed reperfusion was available in real time, the benefits of further therapy in this patient subgroup could be tested. We developed a method of 12-lead ST-segment recovery analysis using continu ... Full text Link to item Cite

A comparison of directional atherectomy with coronary angioplasty in patients with coronary artery disease. The CAVEAT Study Group.

Journal Article N Engl J Med · July 22, 1993 BACKGROUND: Directional coronary atherectomy is a new technique of coronary revascularization by which atherosclerotic plaque is excised and retrieved from target lesions. With respect to the rate of restenosis and clinical outcomes, it is not known how th ... Full text Link to item Cite

Systolic left ventricular function after reperfusion therapy for acute myocardial infarction. Analysis of determinants of improvement. The TAMI Study Group.

Journal Article Circulation · May 1993 BACKGROUND: Contrast ventriculograms of 542 patients treated with intravenous thrombolytic agents for acute myocardial infarction were examined to define changes in left ventricular ejection fraction and regional wall motion that occur during the first wee ... Full text Link to item Cite

Publication criteria for statistical prediction models.

Journal Article Ann Intern Med · February 1, 1993 Full text Link to item Cite

Value of the history and physical in identifying patients at increased risk for coronary artery disease.

Journal Article Ann Intern Med · January 15, 1993 OBJECTIVE: To determine whether information from the physician's initial evaluation of patients with suspected coronary artery disease predicts coronary anatomy at catheterization and 3-year survival. DESIGN: Prospective validation of regression model esti ... Full text Link to item Cite

The irony of biased editors who write editorials

Journal Article British Journal of Clinical Practice · January 1, 1993 Cite

Prevention of sudden death in patients with coronary artery disease: the Multicenter Unsustained Tachycardia Trial (MUSTT).

Journal Article Prog Cardiovasc Dis · 1993 This trial will significantly advance our understanding of the prognostic and therapeutic usefulness of electrophysiologic studies in patients with coronary artery disease. Several features of this trial are worth emphasizing. First, the protocol for perfo ... Full text Link to item Cite

Identification of patients with coronary disease at high risk for loss of employment. A prospective validation study.

Journal Article Circulation · November 1992 BACKGROUND: Work disability is common in patients with coronary artery disease and adversely affects both economic well-being and quality of life. The purpose of this study was to construct a model to predict premature departure from the work force of pati ... Full text Link to item Cite

Observational comparison of event-free survival with medical and surgical therapy in patients with coronary artery disease. 20 years of follow-up.

Journal Article Circulation · November 1992 BACKGROUND: The purpose of this study was to describe the long-term event-free survival patterns of patients with significant coronary artery disease treated medically versus patterns of those treated surgically and to evaluate the factors associated with ... Link to item Cite

A randomized trial of late reperfusion therapy for acute myocardial infarction. Thrombolysis and Angioplasty in Myocardial Infarction-6 Study Group.

Journal Article Circulation · June 1992 BACKGROUND: Experimental and observational clinical studies of acute coronary occlusion have suggested that late reperfusion prevents infarct expansion and facilitates myocardial healing. The purpose of this trial was to assess whether infarct vessel paten ... Full text Link to item Cite

Referral patterns for coronary artery disease treatment: gender bias or good clinical judgment?

Journal Article Ann Intern Med · May 15, 1992 OBJECTIVE: To determine whether a gender bias exists in referral for coronary bypass graft surgery among patients with catheterization-documented coronary artery disease. DESIGN: Historical cohort study (1969 to 1984). SETTING: A referral medical center. P ... Full text Link to item Cite

Confronting the issues of patient safety and investigator conflict of interest in an international clinical trial of myocardial reperfusion

Journal Article Journal of the American College of Cardiology · May 1, 1992 The Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO) trial is a large scale international trial of new myocardial reperfusion strategies. The primary hypothesis is that early and sustained coronary ... Cite

Serum cholesterol in patients undergoing cardiac catheterization for suspected coronary artery disease: diagnostic and prognostic implications.

Journal Article Ann Epidemiol · 1992 The Duke Data Bank for Cardiovascular Diseases is an observational data bank capturing baseline, treatment, and follow-up information on patients referred for evaluation of suspected coronary artery disease. From 6829 patients referred between 1969 and 199 ... Full text Link to item Cite

Observational comparison of event-free survival with medical and surgical therapy in patients with coronary artery disease: 20 Years of follow-up

Journal Article Circulation · January 1, 1992 Background. The purpose of this study was to describe the long-term event-free survival patterns of patients with significant coronary artery disease treated medically versus patterns of those treated surgically and to evaluate the factors associated with ... Cite

Determinants of early versus late cardiac death in patients undergoing coronary artery bypass graft surgery.

Journal Article Circulation · November 1991 Most analyses of risk factors affecting survival after coronary artery bypass graft surgery have not differentiated among factors that influence early and late survival. For this reason, a multiphase model was applied to survival data from 2,967 patients u ... Link to item Cite

Prognostic value of a treadmill exercise score in outpatients with suspected coronary artery disease.

Journal Article N Engl J Med · September 19, 1991 BACKGROUND: The treadmill exercise test identifies patients with different degrees of risk of death from cardiovascular events. We devised a prognostic score, based on the results of treadmill exercise testing, that accurately predicts outcome among inpati ... Full text Link to item Cite

Exercise radionuclide angiocardiography predicts cardiac death in patients with coronary artery disease.

Journal Article Circulation · September 1991 The purpose of this investigation was to document the relative importance of three clinical and three radionuclide variables for prediction of cardiac death in a consecutive group of patients evaluated for coronary artery disease. During a 6 1/2-year perio ... Link to item Cite

Diastolic anisotropic properties of the left ventricle in the conscious dog.

Journal Article Circ Res · September 1991 The role of myocardial anisotropy in determining change in left ventricular shape during diastolic filling has not yet been demonstrated. Therefore, 11 conscious dogs were instrumented with global ultrasonic dimension transducers to measure left ventricula ... Full text Link to item Cite

Prediction of death and myocardial infarction by radionuclide angiocardiography in patients with suspected coronary artery disease.

Journal Article Am J Cardiol · May 1, 1991 The prognostic value of radionuclide angiocardiography was examined in patients with suspected coronary artery disease. Nine hundred and eight patients who underwent rest and exercise radionuclide angiocardiography without subsequent cardiac catheterizatio ... Full text Link to item Cite

Evaluation of combination thrombolytic therapy and timing of cardiac catheterization in acute myocardial infarction. Results of thrombolysis and angioplasty in myocardial infarction--phase 5 randomized trial. TAMI Study Group.

Journal Article Circulation · May 1991 Recent trials of myocardial reperfusion using single-agent thrombolytic therapy and sequential cardiac catheterization have supported a conservative approach to the patient with acute myocardial infarction. To evaluate combination thrombolytic therapy and ... Full text Link to item Cite

Estimating the likelihood of severe coronary artery disease.

Journal Article Am J Med · May 1991 PURPOSE: To determine which clinical characteristics obtained by a physician during an initial clinical examination are important for estimating the likelihood of severe coronary artery disease, and to determine whether estimates based on these characteris ... Link to item Cite

Multivessel coronary artery disease: a key predictor of short-term prognosis after reperfusion therapy for acute myocardial infarction. Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) Study Group.

Journal Article Am Heart J · April 1991 Results of recent studies have suggested that routine cardiac catheterization may be unnecessary after reperfusion therapy for acute myocardial infarction. Therefore to better define the short-term prognostic value of early coronary angiography, and specif ... Full text Link to item Cite

Methods for the analysis and assessment of clinical databases: the clinician's perspective.

Journal Article Stat Med · April 1991 Innovative approaches to analysing clinical databases can be considered from a perspective of innovations that improve the analytical approach or from a more global perspective in which clinical databases themselves are evaluated as a technology. The analy ... Full text Link to item Cite

Complete atrioventricular block complicating inferior wall acute myocardial infarction treated with reperfusion therapy. TAMI Study Group.

Journal Article Am J Cardiol · February 1, 1991 Previous studies report larger myocardial infarcts and increased in-hospital mortality rates in patients with inferior wall acute myocardial infarction (AMI) and complete atrioventricular block (AV), but the clinical implications of these complications in ... Full text Link to item Cite

Exercise radionuclide angiocardiography predicts cardiac death in patients with coronary artery disease

Journal Article Circulation · January 1, 1991 The purpose of this investigation was to document the relative importance of three clinical and three radionuclide variables for prediction of cardiac death in a consecutive group of patients evaluated for coronary artery disease. During a 61/2-year period ... Cite

Using ordinal logistic regression to estimate the likelihood of colorectal neoplasia.

Journal Article J Clin Epidemiol · 1991 The utility of ordinal logistic regression in the prediction of colorectal neoplasia was demonstrated in a group of 461 consecutive patients undergoing colonoscopy in a community practice. One hundred twenty-nine patients had adenomatous polyps and 34 had ... Full text Link to item Cite

Changes in standard electrocardiographic ST-segment elevation predictive of successful reperfusion in acute myocardial infarction.

Journal Article Am J Cardiol · December 15, 1990 The ability of the electrocardiographic ST segment to predict successful reperfusion after thrombolytic therapy remains controversial. To evaluate whether angiographically determined reperfusion could be predicted from changes in ST-segment elevation, the ... Full text Link to item Cite

Prognostic value of radionuclide angiography in medically treated patients with coronary artery disease. A comparison with clinical and catheterization variables.

Journal Article Circulation · November 1990 To evaluate the usefulness of multiple measures from rest and exercise radionuclide angiography (RNA) in predicting cardiovascular death and cardiovascular events (death or nonfatal myocardial infarction) and to assess the prognostic usefulness of the RNA ... Full text Link to item Cite

Two-year outcome after angiographically documented myocardial reperfusion for acute coronary occlusion. Thrombolysis and Angioplasty Study Group.

Journal Article Am J Cardiol · October 1, 1990 Reperfusion therapy has been clearly shown to decrease the early mortality after acute myocardial infarction, but the impact of this therapy on long-term survival has been less extensively evaluated. This study reports the extended follow-up of a large coh ... Full text Link to item Cite

One-year outcome after therapy with tissue plasminogen activator: report from the Thrombolysis and Angioplasty in Myocardial Infarction trial.

Journal Article Am Heart J · April 1990 To evaluate the long-term effects of reperfusion with tissue plasminogen activator (t-PA) and an aggressive strategy of revascularization with angioplasty and coronary artery bypass grafting, we obtained 1-year follow-up results from 386 consecutive patien ... Full text Link to item Cite

Relationship between antecedent angina pectoris and short-term prognosis after thrombolytic therapy for acute myocardial infarction. Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) Study Group.

Journal Article Am Heart J · February 1990 The relationship between preinfarction clinical status and short-term outcome was prospectively evaluated in 775 patients hospitalized with acute myocardial infarction after reperfusion therapy. It was anticipated that a history of angina preceding myocard ... Full text Link to item Cite

Surgical therapy for coronary disease: randomized and observational studies.

Journal Article JAMA · January 5, 1990 Link to item Cite

Heuristic and logistic principles of ST-segment interpretation in the time domain. Evolution in the context of the TAMI 7 trial design.

Journal Article J Electrocardiol · 1990 Full text Link to item Cite

Clinical judgment and therapeutic decision making.

Journal Article J Am Coll Cardiol · January 1990 Clinical decision making is under increased scrutiny due to concerns about the cost and quality of medical care. Variability in physician decision making is common, in part because of deficiencies in the knowledge base, but also due to the difference in ph ... Full text Link to item Cite

Detection of restenosis after elective percutaneous transluminal coronary angioplasty using the exercise treadmill test.

Journal Article Am J Cardiol · January 1, 1990 To determine the value of a 6-month exercise treadmill test for detecting restenosis after elective percutaneous transluminal coronary angioplasty (PTCA), 303 consecutive patients with successful PTCA and without a recent myocardial infarction were studied ... Full text Link to item Cite

·P-18 Need an endpoint for a clinical trial? Just ask

Journal Article Controlled Clinical Trials · January 1, 1990 Full text Cite

Recurrent ischemia without warning. Analysis of risk factors for in-hospital ischemic events following successful thrombolysis with intravenous tissue plasminogen activator.

Journal Article Circulation · November 1989 Ischemic events after successful thrombolysis have been reported to occur in 18-32% of patients treated for acute myocardial infarction with thrombolytic therapy, and previous studies in which patients received streptokinase suggest that risk of early recu ... Full text Link to item Cite

Computing ROC curve confidence intervals for cardiac activation detectors

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology Proceedings · November 1, 1989 It is shown how to use the bootstrap to construct a nonparametric confidence interval for a receiver operating characteristic (ROC) curve. The method is used to perform a statistical comparison of a detectors curve with a particular point in ROC space or t ... Cite

Combined tissue-type plasminogen activator and prostacyclin therapy for acute myocardial infarction. Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) 4 Study Group.

Journal Article J Am Coll Cardiol · October 1989 Current limitations of recombinant tissue-type plasminogen activator (rt-PA) therapy for acute myocardial infarction include failure to achieve recanalization in 25% of patients, reocclusion and reperfusion injury. Iloprost, a stable analogue of prostacycl ... Full text Link to item Cite

Painless exercise ST deviation on the treadmill: long-term prognosis.

Journal Article J Am Coll Cardiol · October 1989 To evaluate the clinical correlates and long-term prognostic significance of silent ischemia during exercise, 1,698 consecutive symptomatic patients with coronary artery disease who had both treadmill testing and cardiac catheterization were studied. These ... Full text Link to item Cite

A brief self-administered questionnaire to determine functional capacity (the Duke Activity Status Index).

Journal Article Am J Cardiol · September 15, 1989 To develop a brief, self-administered questionnaire that accurately measures functional capacity and assesses aspects of quality of life, 50 subjects undergoing exercise testing with measurement of peak oxygen uptake were studied. All subjects were questio ... Full text Link to item Cite

Transient alterations of the QRS complex and ST segment during percutaneous transluminal balloon angioplasty of the right and left circumflex coronary arteries.

Journal Article Am J Cardiol · May 15, 1989 The dynamic QRS amplitude changes that appear during 1-vessel percutaneous transluminal coronary angioplasty of the right and left circumflex coronary arteries were studied in 20 patients using continuous 3-lead electrocardiographic recordings representing ... Full text Link to item Cite

Clinical experience and predicting survival in coronary disease.

Journal Article Arch Intern Med · May 1989 To study the accuracy with which long-term prognosis can be predicted in patients with coronary artery disease, prognostic predictions obtained from a large, diverse sample of practicing cardiologists were compared with predictions from a multivariable sta ... Link to item Cite

The evolution of medical and surgical therapy for coronary artery disease. A 15-year perspective.

Journal Article JAMA · April 14, 1989 To elucidate the factors associated with improved survival following coronary artery bypass surgery, we studied 5809 patients receiving medical or surgical therapy for coronary artery disease. Three factors were associated with a significant surgical survi ... Link to item Cite

A randomized controlled trial of intravenous tissue plasminogen activator and early intravenous heparin in acute myocardial infarction.

Journal Article Circulation · February 1989 To evaluate the coronary thrombolytic efficacy of tissue plasminogen activator (t-PA) and early intravenous heparin, 134 patients with acute myocardial infarction were randomly assigned to combination therapy or t-PA only. At a median of 2.78 hours from sy ... Full text Link to item Cite

Use of ejection fraction as a surrogate endpoint for death in clinical trials of acute myocardial infraction

Journal Article Controlled Clinical Trials · January 1, 1989 Full text Cite

Insights derived from the thrombolysis and angioplasty in myocardial infarction (TAMI) trials.

Journal Article J Am Coll Cardiol · December 1988 In the first three phases of Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) multicenter trials, 708 patients received intravenous recombinant tissue-type plasminogen activator (rt-PA) and underwent detailed assessment of clinical, angiographi ... Full text Link to item Cite

Transient alterations of the QRS complex and ST segment during percutaneous transluminal balloon angioplasty of the left anterior descending coronary artery.

Journal Article Am J Cardiol · November 15, 1988 Using continuous 3-lead electrocardiographic (ECG) recordings in 19 patients undergoing elective percutaneous transluminal coronary artery angioplasty (PTCA) of the left anterior descending (LAD) artery, this study described the dynamic changes of the ST s ... Full text Link to item Cite

Regression models in clinical studies: determining relationships between predictors and response.

Journal Article J Natl Cancer Inst · October 5, 1988 Multiple regression models are increasingly being applied to clinical studies. Such models are powerful analytic tools that yield valid statistical inferences and make reliable predictions if various assumptions are satisfied. Two types of assumptions made ... Full text Link to item Cite

Surgical survival benefits for coronary disease patients with left ventricular dysfunction.

Journal Article Circulation · September 1988 Controversy still exists about the proper selection of patients with coronary artery disease and left ventricular dysfunction for coronary bypass surgery. To examine this issue, we studied 710 patients with significant coronary artery disease and left vent ... Link to item Cite

Changing efficacy of coronary revascularization. Implications for patient selection.

Journal Article Circulation · September 1988 To evaluate the potential impact of patient selection for coronary artery bypass graft surgery on long-term survival, the outcomes of 5,809 consecutive patients with symptomatic coronary disease documented by angiography at Duke University Medical Center w ... Link to item Cite

Clinical behavior of paroxysmal atrial tachycardia.

Journal Article Am J Cardiol · August 25, 1988 Paroxysmal atrial tachycardia is a familiar arrhythmia that has been studied extensively for the past decade using intracardiac recording and programmed electrical stimulation. These studies have thoroughly documented the mechanisms of this arrhythmia and ... Full text Link to item Cite

Coronary arterial thrombolysis with combined infusion of recombinant tissue-type plasminogen activator and urokinase in patients with acute myocardial infarction.

Journal Article Circulation · May 1988 To determine whether tissue-type plasminogen activator (t-PA) and urokinase (UK) act synergistically to achieve coronary thrombolysis, incremental doses of both drugs were infused intravenously over 60 min. In 146 consecutive patients treated 3.0 +/- 1.0 h ... Full text Link to item Cite

Characteristics and outcome of patients in whom reperfusion with intravenous tissue-type plasminogen activator fails: results of the Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) I trial.

Journal Article Circulation · May 1988 To examine the outcome of patients with persistent coronary artery occlusion despite treatment with intravenous tissue-type plasminogen activator (t-PA), the clinical course of 96 patients with persistent occlusion after 90 min of therapy was evaluated. Al ... Full text Link to item Cite

Evaluation of a QRS scoring system for estimating myocardial infarct size. VI: Identification of screening criteria for non-acute myocardial infarcts.

Journal Article Am J Cardiol · April 1, 1988 Each of the 54 criteria in the Selvester 32-point QRS scoring system for estimation of myocardial infarct (MI) size has attained greater than or equal to 95% specificity in normal subjects. This study was performed to identify a subset of those criteria wi ... Full text Link to item Cite

Use of initial ST-segment deviation for prediction of final electrocardiographic size of acute myocardial infarcts.

Journal Article Am J Cardiol · April 1, 1988 The decision to administer thrombolytic therapy for limitation of acute myocardial infarction (AMI) size must occur when only the history, physical examination and 12-lead electrocardiogram of a patient are available. A method that could quickly assess the ... Full text Link to item Cite

Thrombolysis and angioplasty in acute myocardial infarction.

Journal Article N Engl J Med · March 3, 1988 Full text Link to item Cite

Comparison of predictions based on observational data with the results of randomized controlled clinical trials of coronary artery bypass surgery.

Journal Article J Am Coll Cardiol · February 1988 Clinical decisions are most secure when based on findings from several large randomized clinical trials, but relevant randomized trial data are often unavailable. Analyses using clinical data bases might provide useful information if statistical methods ca ... Full text Link to item Cite

Importance of clinical measures of ischemia in the prognosis of patients with documented coronary artery disease.

Journal Article J Am Coll Cardiol · January 1988 To examine the value of clinical measures of ischemia for stratifying prognosis, 5,886 consecutive patients who had symptomatic significant (greater than or equal to 75% stenosis) coronary artery disease were studied. Using the Cox regression model in a ra ... Full text Link to item Cite

Designing clinical trials for paroxysmal atrial tachycardia and other paroxysmal arrhythmias.

Journal Article J Clin Epidemiol · 1988 Paroxysmal atrial tachycardia may be useful as a model for designing clinical trials of paroxysmal tachycardia. Individual occurrences of paroxysmal atrial tachycardia are clinically independent events, and the time periods between events follow an exponen ... Full text Link to item Cite

Surgical survival benefits for coronary disease patients with left ventricular dysfunction

Journal Article Circulation · 1988 Controversy still exists about the proper selection of patients with coronary artery disease and left ventricular dysfunction for coronary bypass surgery. To examine this issue, we studied 710 patients with significant coronary artery disease and left vent ... Cite

Surgical survival benefits for coronary disease patients with left ventricular dysfunction

Journal Article Circulation · January 1, 1988 Controversy still exists about the proper selection of patients with coronary artery disease and left ventricular dysfunction for coronary bypass surgery. To examine this issue, we studied 710 patients with significant coronary artery disease and left vent ... Cite

Changing efficacy of coronary revascularization. Implications for patient selection

Journal Article Circulation · January 1, 1988 To evaluate the potential impact of patient selection for coronary artery bypass graft surgery on long-term survival, the outcomes of 5,809 consecutive patients with symptomatic coronary disease documented by angiography at Duke University Medical Center w ... Cite

USE OF COMPUTERIZED STATISTICAL MODELS TO EDUCATE MEDICAL HOUSESTAFF IN ESTIMATING CLINICAL OUTCOMES.

Journal Article Proceedings Annual Symposium on Computer Applications in Medical Care · December 1, 1987 The suggestion that computerized diagnostic and prognostic predictions from statistical models would improve the ability of medical housestaff to estimate outcomes in patients with coronary artery disease (CAD) was experimentally tested. Interns made estim ... Cite

The changing survival benefits of coronary revascularization over time.

Journal Article Circulation · November 1987 Previous comparisons of medical and surgical therapy for coronary artery disease were performed in the 1970s and may need to be updated to reflect current treatment efficacy. The purpose of this investigation was to determine the impact on long-term patien ... Link to item Cite

A randomized trial of immediate versus delayed elective angioplasty after intravenous tissue plasminogen activator in acute myocardial infarction.

Journal Article N Engl J Med · September 3, 1987 We compared the efficacy of immediate coronary angioplasty after acute myocardial infarction with that of elective angioplasty at 7 to 10 days in patients treated initially with intravenous tissue plasminogen activator. The plasminogen activator (150 mg) w ... Full text Link to item Cite

Exercise treadmill score for predicting prognosis in coronary artery disease.

Journal Article Ann Intern Med · June 1987 To determine the prognostic value of the treadmill exercise test, we evaluated 2842 consecutive patients with chest pain who had both treadmill testing cardiac catheterization. The population was randomly divided into two equal-sized groups and the Cox reg ... Full text Link to item Cite

Rethinking sensitivity and specificity.

Journal Article Am J Cardiol · May 1, 1987 Full text Link to item Cite

Prognostic effect of bundle branch block related to coronary artery bypass grafting.

Journal Article Am J Cardiol · April 1, 1987 The incidence and prognostic effect of the development of new perioperative ventricular conduction abnormalities were examined in all patients undergoing coronary artery bypass surgery at Duke University Medical Center between 1976 and 1981. Of the 913 pat ... Full text Link to item Cite

Comparison of survival of amiodarone-treated patients with coronary artery disease and malignant ventricular arrhythmias with that of a control group with coronary artery disease.

Journal Article J Am Coll Cardiol · April 1987 Although amiodarone is effective in the treatment of ventricular arrhythmias, it is associated with serious toxic effects. In addition, the prognosis of patients with malignant ventricular arrhythmias and coronary artery disease treated with amiodarone rem ... Full text Link to item Cite

Identification of the optimal electrocardiographic leads for detecting acute epicardial injury in acute myocardial infarction.

Journal Article Am J Cardiol · January 1, 1987 Current coronary care electrocardiographic (ECG) monitoring techniques are aimed at detection of cardiac arrhythmias rather than myocardial ischemia. However, in patients with acute myocardial infarction (AMI) who undergo reperfusion therapy, monitoring ST ... Full text Link to item Cite

Localizing coronary artery obstructions with the exercise treadmill test.

Journal Article Ann Intern Med · January 1987 To determine if patterns of ST depression or elevation during exercise testing provide reliable information about the location of an underlying coronary lesion, we studied 452 consecutive patients with one-vessel disease who underwent treadmill testing. Ex ... Full text Link to item Cite

The changing survival benefits of coronary revascularization over time

Journal Article Circulation · January 1, 1987 Previous comparisons of medical and surgical therapy for coronary artery disease were performed in the 1970s and may need to be updated to reflect current treatment efficacy. The purpose of this investigation was to determine the impact on long-term patien ... Cite

Prognostic implications of angiographically normal and insignificantly narrowed coronary arteries.

Journal Article Am J Cardiol · December 1, 1986 The clinical presentation and prognosis of 1,977 consecutive patients with normal coronary arteries or "insignificant" coronary artery disease (CAD) (no major epicardial artery with 75% or more luminal diameter narrowing) were examined. Compared with patie ... Full text Link to item Cite

Incidence of symptomatic tachycardia in untreated patients with paroxysmal supraventricular tachycardia.

Journal Article Arch Intern Med · November 1986 The purpose of this article is to investigate the occurrence of symptomatic paroxysmal supraventricular tachycardia (PSVT) in untreated patients and to assess factors that influenced its occurrence. We studied 34 patients with this arrhythmia during an obs ... Link to item Cite

Predicting outcome in coronary disease. Statistical models versus expert clinicians.

Journal Article Am J Med · April 1986 To study the accuracy with which long-term prognosis can be predicted in patients with coronary artery disease, prognostic predictions from a data-based multivariable statistical model were compared with predictions from senior clinical cardiologists. Test ... Full text Link to item Cite

Analysis of sequential treatment protocols for endometriosis-associated infertility.

Journal Article Am J Obstet Gynecol · March 1986 The evaluation of comparative pregnancy data in clinical studies is subject to a variety of biases. One such bias, when treated patients are retrospectively compared with untreated control subjects, results from the fact that treated patients must remain i ... Full text Link to item Cite

Observations on the occurrence of atrial fibrillation in paroxysmal supraventricular tachycardia.

Journal Article Am J Cardiol · March 1, 1986 Paroxysmal supraventricular tachycardia (PSVT) and atrial fibrillation (AF) are both supraventricular arrhythmias, but their mechanisms are completely different. This study determines the incidence of symptomatic AF in a group of patients followed closely ... Full text Link to item Cite

Psychosocial and physical predictors of anginal pain relief with medical management.

Journal Article Psychosom Med · 1986 This study was undertaken to identify psychosocial and physical characteristics that independently predict anginal pain relief. The original study group comprised over 570 patients in whom the characteristics were identified at the time of coronary arterio ... Full text Link to item Cite

Randomized trials of coronary artery bypass surgery: Impact on clinical practice at Duke University Medical Center

Journal Article Circulation · December 1, 1985 Trends in practice patterns at Duke University Medical Center were assessed in patient groups comparable to those enrolled in the three major randomized trials of coronary artery bypass grafting (CABG). In addition, changes in practice patterns that appear ... Cite

Regression models for prognostic prediction: advantages, problems, and suggested solutions.

Journal Article Cancer Treat Rep · October 1985 Multiple regression models have wide applicability in predicting the outcome of patients with a variety of diseases. However, many researchers are using such models without validating the necessary assumptions. All too frequently, researchers also "overfit ... Link to item Cite

Prognostic value of a coronary artery jeopardy score.

Journal Article J Am Coll Cardiol · May 1985 The prognostic value of a coronary artery jeopardy score was evaluated in 462 consecutive nonsurgically treated patients with significant coronary artery disease, but without significant left main coronary stenosis. The jeopardy score is a simple method fo ... Full text Link to item Cite

Clinical data bases. Accomplishments and unrealized potential.

Journal Article Med Care · May 1985 Full text Link to item Cite

Analysis of risk factors for sudden death after acute myocardial infarction.

Journal Article Am J Cardiol · February 15, 1985 Full text Link to item Cite

Prognostic significance of precordial ST-segment depression during inferior acute myocardial infarction.

Journal Article Am J Cardiol · February 1, 1985 To study the mechanism and prognostic importance of precordial ST-segment depression during inferior acute myocardial infarction, 162 patients admitted during 1969 through 1982 were identified. Patients with ST depression in leads V1, V2 and V3 had signifi ... Full text Link to item Cite

Assessment of regional left ventricular function using gated radionuclide angiography.

Journal Article Am J Cardiol · August 1, 1984 A simple method for the assessment of regional left ventricular (LV) function using gated radionuclide angiography is described. The method divides the LV region of interest in the left anterior oblique view into quadrants using a count-weighted center poi ... Full text Link to item Cite

The spontaneous occurrence of paroxysmal supraventricular tachycardia.

Journal Article Circulation · July 1984 The seemingly unpredictable occurrence of paroxysmal supraventricular tachycardia has impeded understanding of its clinical course. We documented recurring tachycardia by telephone transmission of the electrocardiogram in 14 patients and measured the "tach ... Full text Link to item Cite

"Left main equivalent" coronary artery disease: its clinical presentation and prognostic significance with nonsurgical therapy.

Journal Article Am J Cardiol · June 1, 1984 The clinical characteristics and nonsurgical prognosis of 55 patients with "left main (LM) equivalent" coronary artery disease (CAD) were evaluated and defined as: (1) greater than or equal to 75% diameter reduction of the left anterior descending coronary ... Full text Link to item Cite

Accuracy and interobserver variability of coronary cineangiography: a comparison with postmortem evaluation.

Journal Article J Am Coll Cardiol · May 1984 The accuracy of interpretation of coronary cineangiography by two independent observers was tested against postmortem findings in 27 patients who died within 6 months of cardiac catheterization. Variations in cineangiographic interpretations between the an ... Full text Link to item Cite

Clinical characteristics and long-term survival of patients with variant angina.

Journal Article Circulation · May 1984 We studied 109 consecutive patients with variant angina who underwent cardiac catheterization over an 11 year period. All patients were followed for at least 6 months or until death, and 46 patients (22 treated medically and 24 treated surgically) were fol ... Full text Link to item Cite

Regression modelling strategies for improved prognostic prediction.

Journal Article Stat Med · 1984 Regression models such as the Cox proportional hazards model have had increasing use in modelling and estimating the prognosis of patients with a variety of diseases. Many applications involve a large number of variables to be modelled using a relatively s ... Full text Link to item Cite

Prognostic indicators from radionuclide angiography in medically treated patients with coronary artery disease.

Journal Article Am J Cardiol · January 1, 1984 The purpose of this investigation was to determine which variables obtained when performing radionuclide angiography predict subsequent survival or total events (cardiovascular death or nonfatal myocardial infarction) in stable patients with symptomatic co ... Full text Link to item Cite

Tying clinical research to patient care by use of an observational database.

Journal Article Stat Med · 1984 Full text Link to item Cite

The effect of crossovers on estimates of survival in medically treated patients with coronary artery disease.

Journal Article J Chronic Dis · 1984 Among 1661 consecutive patients with significant coronary artery disease treated medically at the Duke University Medical Center, 239 have undergone aortocoronary bypass surgery after at least 6 months of medical management. The purpose of this investigati ... Full text Link to item Cite

Prognostic value of ventricular arrhythmias associated with treadmill exercise testing in patients studied with cardiac catheterization for suspected ischemic heart disease.

Journal Article J Am Coll Cardiol · December 1983 The prognostic information provided by ventricular arrhythmias associated with treadmill exercise testing was evaluated in 1,293 consecutive nonsurgically treated patients undergoing an exercise test within 6 weeks of cardiac catheterization. The 236 patie ... Full text Link to item Cite

USING EXPERIENCE TO IMPROVE CLINICAL DECISION MAKING.

Journal Article Proceedings Annual Symposium on Computer Applications in Medical Care · December 1, 1983 Cite

Estimating the likelihood of significant coronary artery disease.

Journal Article Am J Med · November 1983 Among 23 clinical characteristics examined in 3,627 consecutive, symptomatic patients referred for cardiac catheterization between 1969 and 1979, nine were found to be important for estimating the likelihood a patient had significant coronary artery diseas ... Full text Link to item Cite

The prognosis for patients with new-onset angina who have undergone cardiac catheterization.

Journal Article Circulation · November 1983 We investigated the prognostic significance of new-onset angina in patients in whom coronary anatomic characteristics were known. New onset angina was defined as angina of less than 3 months duration. Consecutive patients (n = 1727) with significant corona ... Full text Link to item Cite

Life-table methods for evaluating antiarrhythmic drug efficacy in patients with paroxysmal atrial tachycardia.

Journal Article Am J Cardiol · November 1, 1983 Spontaneous variability in the occurrence of paroxysmal arrhythmias has made it difficult to apply objective and quantitative methods to describe their clinical course. In this study of paroxysmal atrial tachycardia, the "tachycardia-free interval" was use ... Full text Link to item Cite

The use of radionuclide angiography in the diagnosis of coronary artery disease--a logistic regression analysis.

Journal Article Circulation · October 1983 We applied logistic regression analysis to a group of 736 patients with chest pain to determine which radionuclide angiographic (RNA) parameters were most useful in the diagnosis of significant coronary artery disease. The most useful parameters were exerc ... Full text Link to item Cite

Diagnostic test use in different practice settings. A controlled comparison.

Journal Article Arch Intern Med · October 1983 Health maintenance organizations (HMOs) have lower than average medical care costs, but the reasons remain controversial. The diagnostic practices of cardiologists from an HMO, a university, and a community were therefore surveyed. First, cardiologists def ... Link to item Cite

An improving prognosis over time in medically treated patients with coronary artery disease.

Journal Article Am J Cardiol · September 1, 1983 The national mortality rate from coronary heart disease has decreased during the past decade, for reasons that are not yet clear. The mortality rate and the total number of cardiovascular events both decreased during the last 10 years in 1,911 medically tr ... Full text Link to item Cite

A comparison of test statistics for assessing the effects of concomitant variables in survival analysis.

Journal Article Biometrics · June 1983 In data analysis involving the proportional-hazards regression model due to Cox (1972, Journal of the Royal Statistical Society, Series B 34, 187-220), the test criteria commonly used for assessing the partial contribution to survival of subsets of concomi ... Link to item Cite

Discriminant function analysis using thallium-201 scintiscans and exercise stress variables to predict coronary heart disease.

Journal Article Am J Cardiol · May 15, 1983 Full text Link to item Cite

The effect of duration of hypothermic cardioplegia on ventricular function.

Journal Article J Thorac Cardiovasc Surg · April 1983 Link to item Cite

Outcome in one-vessel coronary artery disease.

Journal Article Circulation · February 1983 We analyzed the clinical outcomes in 688 patients with isolated stenosis of one major coronary artery. The survival rate among patients with disease of the right coronary artery (RCA) was higher than that among patients with left anterior descending (LAD) ... Full text Link to item Cite

Assessment of the use of the age- and sex-specific United States population as a control group for analysis of survival in coronary artery disease.

Journal Article Am J Cardiol · December 1982 The use of the age- and sex-specific U.S. population as a control group for analysis of survival in coronary artery disease was assessed. Population-based survival rates were calculated for nonsurgically treated patients evaluated for coronary artery disea ... Full text Link to item Cite

Incremental value of the exercise test for diagnosing the presence or absence of coronary artery disease.

Journal Article Circulation · November 1982 To determine the incremental value of the exercise test (ETT) for diagnosing coronary artery disease (CAD), we derived a multivariate logistic regression model for the pre-ETT prediction of CAD using data from 3840 patients at Duke University. We then appl ... Full text Link to item Cite

Ejection fraction response to exercise in patients with chest pain, coronary artery disease and normal resting ventricular function.

Journal Article Circulation · September 1982 We studied the ejection fraction (EF) response to upright exercise using first-pass radionuclide angiography (RNA) in 281 patients with chest pain, significant coronary artery disease and normal resting ventricular function. A wide range of resting functio ... Full text Link to item Cite

Hemodynamic effects of the antiarrhythmic drug pirmenol.

Journal Article Clin Pharmacol Ther · August 1982 We examined the hemodynamic effects of pirmenol, a new antiarrhythmic drug, for the first time in man. Right and left heart pressures, Fick cardiac output, and radionuclide ejection fraction were measured before and during infusion of pirmenol in 10 patien ... Full text Link to item Cite

Prognostic implications of ventricular arrhythmias during 24 hour ambulatory monitoring in patients undergoing cardiac catheterization for coronary artery disease.

Journal Article Am J Cardiol · July 1982 The prognostic importance of ventricular arrhythmias detected during 24 hour ambulatory monitoring was evaluated in 395 patients with and 260 patients without significant coronary artery disease. Ventricular arrhythmias were found to be strongly related to ... Full text Link to item Cite

Problems and advantages of an observational data base approach to evaluating the effect of therapy on outcome.

Journal Article Circulation · June 1982 In this report, we summarize the strengths and problems of an observational data base approach to evaluating therapy and studying patient outcomes in long-term chronic disease. Because this approach includes a greater spectrum of patients than randomized c ... Full text Link to item Cite

Survival of coronary artery disease patients with stable pain and normal left ventricular function treated medically or surgically at Duke University.

Journal Article Circulation · June 1982 We evaluated the survival rates of medically and surgically treated patients with one-, two- or three-vessel coronary disease (CAD), stable pain, and normal left ventricular function observed at the Duke University Medical Center over an 11-year period. Th ... Full text Link to item Cite

Evaluating the yield of medical tests.

Journal Article JAMA · May 14, 1982 A method is presented for evaluating the amount of information a medical test provides about individual patients. Emphasis is placed on the role of a test in the evaluation of patients with a chronic disease. In this context, the yield of a test is best in ... Link to item Cite

A data-based approach to assessing clinical interventions in the setting of chronic disease.

Journal Article Cancer Treat Rep · May 1982 Accurately assessing the effect of a clinical intervention is a complex task based on observing patients and their outcomes. Two strategies, the randomized trial and the observational data bank, represent different approaches toward detecting an outcome gr ... Link to item Cite

Survival of coronary artery disease patients with stable pain and normal left ventricular function treated medically or surgically at Duke University

Journal Article Circulation · 1982 We evaluated the survival rates of medically and surgically treated patients with one-, two- or three-vessel coronary artery disease (CAD), stable pain, and normal left ventricular function observed at the Duke University Medical Center over an 11-year per ... Cite

Problem and advantages of an observational data base approach to evaluating the effect of therapy on outcome

Journal Article Circulation · 1982 In this report, we summarize the strengths and problems of an observational data base approach to evaluating therapy and studying patient outcomes in long-term chronic disease. Because this approach includes a greater spectrum of patients than randomized c ... Cite

Methacholine-induced cutaneous flare response: bivariate analysis of responsiveness and sensitivity.

Journal Article J Allergy Clin Immunol · January 1982 Cutaneous reactions to allergens exhibit a sigmoid dose-response relationship. Available methods for evaluating the allergen skin-test response do not adequately account for the sigmoid curve. Methodologic factors handicap quantitative studies of allergens ... Full text Link to item Cite

Problem and advantages of an observational data base approach to evaluating the effect of therapy on outcome

Journal Article Circulation · January 1, 1982 In this report, we summarize the strengths and problems of an observational data base approach to evaluating therapy and studying patient outcomes in long-term chronic disease. Because this approach includes a greater spectrum of patients than randomized c ... Cite

Ejection fraction response to exercise in patients with chest pain and normal coronary arteriograms.

Journal Article Circulation · November 1981 In this study we describe the ejection fraction response to upright exercise using first-pass radionuclide angiocardiography in a group of 60 patients with chest pain, normal coronary arteriograms and normal resting ventricular function. A wide range of re ... Full text Link to item Cite

Additional comments on "some statistical methods useful in circulation research".

Journal Article Circ Res · April 1981 Link to item Cite

Risk of exogenous estrogen therapy and endometrial cancer

Journal Article Gynakologisch Geburtshilfliche Rundschau · January 1, 1981 Full text Cite

Nonfatal myocardial infarction in medically treated patients with coronary artery disease.

Journal Article Am J Cardiol · December 1, 1980 The purpose of this study was to identify patient characteristics associated with nonfatal myocardial infarction as the first event after cardiac catheterization in medically treated patients with coronary artery disease. Multiple logistic risk analysis of ... Full text Link to item Cite

Type A behavior, hostility, and coronary atherosclerosis.

Journal Article Psychosom Med · November 1980 Type A behavior pattern was assessed using the structured interview and hostility level was assessed using a subscale of the Minnesota Multiphase Personality Inventory in 424 patients who underwent diagnostic coronary arteriography for suspected coronary h ... Full text Link to item Cite

Outcome in medically treated coronary artery disease. Ischemic events: nonfatal infarction and death.

Journal Article Circulation · October 1980 In this study we extended the characterization of outcome in 1214 medically treated patients with coronary disease by considering nonfatal infarction and death together as ischemic events. At 7 years, the cumulative event rate was 47% (18% for nonfatal inf ... Full text Link to item Cite

The prognostic significance of 50% coronary stenosis in medically treated patients with coronary artery disease.

Journal Article Circulation · August 1980 Full text Link to item Cite

On the complexity of investigating chronic illness.

Journal Article Biometrics · June 1980 Chronic diseases are in many ways more complex than acute diseases. In chronic diseases, response times to environmental effects are long, and confounding variables are numerous and may fluctuate with time. Treatment schedules are complicated and may be un ... Link to item Cite

Risk of exogenous estrogen therapy and endometrial cancer.

Journal Article Am J Obstet Gynecol · May 1, 1980 A retrospective study was carried out on 431 patients with endometrial cancer and 431 control subjects matched as to age, race, and parity. They were seen at Duke University Medical Center from 1940 to 1975. The study was performed in order to evaluate the ... Full text Link to item Cite

Clinical judgment and statistics. Lessons from a simulated randomized trial in coronary artery disease.

Journal Article Circulation · March 1980 A simulated randomized clinical trial in coronary artery disease was conducted to illustrate the need for clinical judgment and modern statistical methods in assessing therapeutic claims in studies of complex diseases. Clinicians should be aware of problem ... Full text Link to item Cite

Survival in medically treated coronary artery disease.

Journal Article Circulation · December 1979 Full text Link to item Cite

Effects of long-term estrogen replacement therapy. II. Neoplasia.

Journal Article Am J Obstet Gynecol · March 1, 1979 Two groups of hypoestrogenic women are analyzed by retrospective comparison. Patients were observed by a single group of physicians for at least five years -- 301 patients treated with replacement estrogen and 309 untreated patients. Of each group, 207 wom ... Full text Link to item Cite

Effects of long-term estrogen replacement therapy. I. Metabolic effects.

Journal Article Am J Obstet Gynecol · March 1, 1979 Two groups of hypoestrogenic women are analyzed by retrospective comparisons. Patients were observed by a single group of physicians for at least five years; 301 patients were treated with replacement estrogen and 309 patients were untreated. Incidence fig ... Full text Link to item Cite

Effects of long-term estrogen replacement therapy. II. Neoplasia

Journal Article Obstetrical and Gynecological Survey · January 1, 1979 Full text Cite

DATABASE APPROACH FOR STABILIZING CLINICAL DECISIONS IN THE SETTING OF CHRONIC ILLNESS.

Journal Article Institution of Mechanical Engineers Conference Publications · January 1, 1979 Stabilizing clinical decisions can be aided by incorporating outcome data into treatment decisions. Feedback of outcome data can be managed manually for acute illnesses. When the time between intervention and outcome becomes long as in chronic disease, the ... Cite

Relationship between regional myocardial procainamide concentration and regional myocardial blood flow during ischemia in the dog.

Journal Article Circ Res · June 1978 Full text Link to item Cite

The prognostic spectrum of left main stenosis.

Journal Article Circulation · May 1978 Three-year survival for 163 consecutive medically treated patients with 50% or greater left main stenosis was 50%. Survival was significantly higher for patients with 50 to 70% left main stenosis (one and three-year survivals of 91% and 66%) than for patie ... Full text Link to item Cite

The role of the exercise test in the evaluation of patients for ischemic heart disease.

Journal Article Circulation · January 1978 A cohort of 1472 patients who underwent both exercise stress testing and coronary angiography within six weeks was examined. The data indicated that a combination of exercise parameters is both diagnostically and prognostically important. Almost all patien ... Full text Link to item Cite

The natural history of coronary artery disease: an update on surgical and medical management.

Journal Article Trans Am Clin Climatol Assoc · 1978 The current series represents the total experience of one institution that has treated concurrently a large number of patients with medical or surgical therapy. As previously reported, surgery offers a greater chance for pain relief but no obvious protecti ... Link to item Cite

Statistical methods for evaluating responses in HLA-D typing.

Journal Article Transplant Proc · March 1977 Link to item Cite

Cardiac arrest complicating acute myocardial infarction: predictability and prognosis.

Journal Article Am J Cardiol · January 1977 Eleven percent of 905 consecutive patients with acute myocardial infarction admitted to the coronary care unit at Duke University Medical Center experienced cardiac arrest. Subgroups of patients at high and low risk for cardiac arrest were identified. Card ... Full text Link to item Cite

Does coronary surgery prolong life in comparison with medical management?

Journal Article Postgrad Med J · December 1976 This analysis attempts to utilize natural history controls to answer the question as to whether coronary surgery prolongs life in comparison to medical management. Selected natural history studies are compared and contrasted in an effort to obtain an avera ... Full text Link to item Cite

A mathematical approach to medical decisions: application of Bayes' rule to a mixture of continuous and discrete clinical variables.

Journal Article Comput Biomed Res · December 1976 Full text Link to item Cite