Scholars@Duke
Paul C. Kuo

Paul C. Kuo

Adjunct Professor in the Department of Surgery
Surgery
kuo00004@mc.duke.edu
Box 3522 Med Ctr, Durham, NC 27710
110 Bell Bldg, Durham, NC 27710

Selected Publications

Big data: More than big data sets.

Journal Article Surgery · October 2018 The term big data has been popularized over the past decade and is often used to refer to data sets that are too large or complex to be analyzed by traditional means. Although the term has been utilized for some time in business and engineering, the concep ... Full text Link to item Cite

Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis.

Journal Article PLoS One · 2016 Osteopontin (OPN) promotes hepatic fibrosis, and developing therapies targeting OPN expression in settings of hepatic injury holds promise. The polyphenol epigallocatechin-3-gallate (EGCG), found in high concentrations in green tea, downregulates OPN expre ... Full text Link to item Cite

Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication.

Journal Article Clin Sci (Lond) · June 2014 OPN (osteopontin)) is a Hh (Hedgehog)-regulated cytokine that is up-regulated during chronic liver injury and directly promotes fibrosis. We have reported that Hh signalling enhances viral permissiveness and replication in HCV (hepatitis C virus)-infected ... Full text Link to item Cite

Liver transplantation

Chapter · January 1, 2013 Full text Cite

An analytic decision support tool for resident allocation.

Journal Article J Surg Educ · 2013 BACKGROUND: Moving residents through an academic residency program is complicated by a number of factors. Across all residency programs the percentage of residents that leave for any reason is between 3.4% and 3.8%.(1) There are a number of residents that ... Full text Link to item Cite

Impact of business infrastructure on financial metrics in departments of surgery.

Journal Article Surgery · October 2012 BACKGROUND: In the current environment, pressure is ever increasing to maximize financial performance in surgery departments. Factors such as physician extenders, billing and collection, payor mix, contracting, incentives from the Centers for Medicare and ... Full text Link to item Cite

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease.

Journal Article Gut · September 2012 OBJECTIVE: Immune responses are important in dictating non-alcoholic steatohepatitis (NASH) outcome. We previously reported that upregulation of hedgehog (Hh) and osteopontin (OPN) occurs in NASH, that Hh-regulated accumulation of natural killer T (NKT) ce ... Full text Link to item Cite

Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers.

Journal Article Surgery · September 2012 BACKGROUND: The microenvironments of neoplasms influence both mesenchymal stem cell differentiation into cancer-associated fibroblasts (CAF) and tumor cell line differentiation to mesenchymal phenotypes via epithelial-to-mesenchymal transition (EMT). Using ... Full text Link to item Cite

The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity.

Journal Article J Surg Res · July 2012 BACKGROUND: Scarring is believed to be caused by both persistent inflammation and overexuberant fibroblast activation. Osteopontin (OPN) is a cytokine that promotes cell activation. The absence of OPN in vivo reduces dermal scarring. This suggests that OPN ... Full text Link to item Cite

Osteopontin regulates epithelial mesenchymal transition-associated growth of hepatocellular cancer in a mouse xenograft model.

Journal Article Ann Surg · February 2012 OBJECTIVE: To determine the efficacy of osteopontin (OPN) targeting in hepatocellular cancer (HCC). SUMMARY/BACKGROUND: OPN is associated with HCC growth and metastasis and represents a unique therapeutic target. METHODS: OPN and epithelial-mesenchymal tra ... Full text Link to item Cite

Stress and coping in caregivers of patients awaiting solid organ transplantation.

Journal Article Clin Transplant · 2012 Caregivers for patients undergoing solid organ transplantation play an essential role in the process of transplantation. However, little is known about stress and coping among these caregivers. Six hundred and twenty-one primary caregivers of potential can ... Full text Link to item Cite

Imaging appearance of surgical sponges at 1.5 T MRI: an in vitro study.

Journal Article Eur J Radiol · November 2011 OBJECTIVE: To predict the MR appearance of retained surgical textiles in the acute setting by using an in vitro phantom and body MR imaging protocols. METHODS: Three surgical sponges were embedded in clear gelatin. One of these sponges was soaked in fresh ... Full text Link to item Cite

Pharmacokinetic characterization of an RNA aptamer against osteopontin and demonstration of in vivo efficacy in reversing growth of human breast cancer cells.

Journal Article Surgery · August 2011 BACKGROUND: We report pharmacokinetic (PK) data, evaluation of modifications for increased stability, evaluation for cellular uptake, and mediation of regression of breast cancer for the aptamer OPN-R3. METHODS: The OPN-R3 aptamer was assessed for PK data ... Full text Link to item Cite

Does protected research time during general surgery training contribute to graduates' career choice?

Journal Article Am Surg · July 2011 A number of general surgery training programs offer a dedicated research experience during the training period. There is much debate over the importance of these experiences with the added constraints placed on training surgeons including length of trainin ... Link to item Cite

Nitric oxide and redox regulation in the liver: part II. Redox biology in pathologic hepatocytes and implications for intervention.

Journal Article J Surg Res · May 1, 2011 Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are created in normal hepatocytes and are critical for normal physiologic processes, including oxidative respiration, growth, regeneration, apoptosis, and microsomal defense. When the levels ... Full text Link to item Cite

Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis.

Journal Article Carcinogenesis · April 2011 The interaction between cancer and its local microenvironment can determine properties of growth and metastasis. A critical component of the tumor microenvironment in this context is the cancer-associated fibroblast (CAF), which can promote tumor growth, a ... Full text Link to item Cite

NF-κB- and AP-1-mediated DNA looping regulates osteopontin transcription in endotoxin-stimulated murine macrophages.

Journal Article J Immunol · March 1, 2011 Osteopontin (OPN) is expressed by various immune cells and modulates both innate and adaptive immune responses. However, the molecular mechanisms that control opn gene expression, especially at the chromatin level, remain largely unknown. We have previousl ... Full text Link to item Cite

Peroxisome proliferator-activated receptor gamma negatively regulates IFN-beta production in Toll-like receptor (TLR) 3- and TLR4-stimulated macrophages by preventing interferon regulatory factor 3 binding to the IFN-beta promoter.

Journal Article J Biol Chem · February 18, 2011 Toll-like receptors 3 and 4 utilize adaptor TRIF to activate interferon regulatory factor 3 (IRF3), resulting in IFN-β production to mediate anti-viral and bacterial infection. Peroxisome proliferator-activated receptor (PPAR)-γ is a ligand-activated trans ... Full text Link to item Cite

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.

Journal Article Hepatology · January 2011 UNLABELLED: Nonalcoholic steatohepatitis (NASH) is a leading cause of cirrhosis. Recently, we showed that NASH-related cirrhosis is associated with Hedgehog (Hh) pathway activation. The gene encoding osteopontin (OPN), a profibrogenic extracellular matrix ... Full text Link to item Cite

Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages.

Journal Article J Biol Chem · November 26, 2010 The molecular pathways regulating signal transducer and activator of transcription 1 (STAT1) levels in states of inflammation are incompletely understood. The suppressor of cytokine signaling, protein inhibitor of STAT, and SHP-1/2 tyrosine phosphatases ul ... Full text Link to item Cite

Micro-RNA-181a regulates osteopontin-dependent metastatic function in hepatocellular cancer cell lines.

Journal Article Surgery · August 2010 BACKGROUND: Osteopontin (OPN) is a variably expressed, secreted glycophosphoprotein that mediates the growth and metastases of hepatocellular cancer (HCC). MicroRNAs (miRNAs) may be responsible for variant OPN expression, interrupting translation by bindin ... Full text Link to item Cite

Personality differences between surgery residents, nonsurgery residents, and medical students.

Journal Article Surgery · August 2010 BACKGROUND: The Five-Factor Model (FFM) of personality may provide a useful framework to understand performance-related issues in academic medical settings. We examined the distribution of FFM personality traits among surgery residents compared with medici ... Full text Link to item Cite

Differential expression of intracellular and secreted osteopontin isoforms by murine macrophages in response to toll-like receptor agonists.

Journal Article J Biol Chem · July 2, 2010 Osteopontin (OPN), expressed by various immune cells, modulates both innate and adaptive immune responses. Different immune cells have shown differential expression of the two isoforms of OPN: secreted form of OPN (sOPN) and intracellular form of OPN (iOPN ... Full text Link to item Cite

Nitric oxide and redox regulation in the liver: Part I. General considerations and redox biology in hepatitis.

Journal Article J Surg Res · July 2010 Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are created in normal hepatocytes and are critical for normal physiologic processes, including oxidative respiration, growth, regeneration, apoptosis, and microsomal defense. When the levels ... Full text Link to item Cite

Trends in the utilization of high-volume hospitals by minority and underinsured surgical patients.

Journal Article Am Surg · May 2010 Race- and insurance-based disparities exist in the utilization of high-volume hospitals for complex surgery. Retrospective analysis of the Nationwide Inpatient Sample from 1988 through 2005 was performed to examine hospital volume trends for eight procedur ... Link to item Cite

Transjugular biopsy results in the transplanted liver: comparison of two surgical hepatic venous anastomotic configurations in 269 consecutive biopsies over a 14-year period.

Journal Article J Vasc Interv Radiol · April 2010 PURPOSE: To compare the results of transjugular liver biopsy in patients who have undergone liver transplantation via an inline versus a "piggyback" hepatic venous surgical anastomosis. MATERIALS AND METHODS: From October 1994 to July 2008 (165 months), 26 ... Full text Link to item Cite

Temporal trends in lung transplant center volume and outcomes in the United States.

Journal Article Transplantation · March 27, 2010 Publicly available program-specific data from the scientific registry of transplant recipients were used to determine the association between adult lung transplant center volume and 1-year recipient mortality from 2000 to 2007. We found a significant inver ... Full text Link to item Cite

Low volume is associated with worse patient outcomes for pediatric liver transplant centers.

Journal Article J Pediatr Surg · January 2010 BACKGROUND: An inverse association between hospital procedure volume and postoperative mortality has been demonstrated for a variety of pediatric surgical procedures. The objective of our study was to determine whether such an association exists for pediat ... Full text Link to item Cite

Innate pathways of immune activation in transplantation.

Journal Article J Transplant · 2010 Studies of the immune mechanisms of allograft rejection have predominantly focused on the adaptive immune system that includes T cells and B cells. Recent investigations into the innate immune system, which recognizes foreign antigens through more evolutio ... Full text Link to item Cite

A prospective, randomized, multicenter study evaluating early corticosteroid withdrawal with Thymoglobulin in living-donor kidney transplantation.

Journal Article Clin Transplant · 2010 BACKGROUND: This study compared the safety and efficacy of early corticosteroid withdrawal (ECSWD) with rabbit anti-thymocyte globulin (rATG) induction to chronic corticosteroid therapy (CCST) without antibody induction in primary, living-donor renal trans ... Full text Link to item Cite

Will the clinicians support the researchers and teachers? Results of a salary satisfaction survey of 947 academic surgeons.

Journal Article Ann Surg · September 2009 OBJECTIVE: To determine whether academic surgeons are satisfied with their salaries, and if they are willing to forego some compensation to support departmental academic endeavors. BACKGROUND: Increasing financial constraints have led many academic surgery ... Full text Link to item Cite

Temporal trends in liver transplant centre volume in the USA.

Journal Article HPB (Oxford) · August 2009 BACKGROUND: Although prior studies have suggested an inverse association between liver transplant centre volume and postoperative patient mortality, more recent analyses have failed to confirm this association. To date, all studies of the relationship betw ... Full text Link to item Cite

Identification of osteopontin-dependent signaling pathways in a mouse model of human breast cancer.

Journal Article BMC Res Notes · July 1, 2009 BACKGROUND: Osteopontin (OPN) is a secreted phosphoprotein which functions as a cell attachment protein and cytokine that signals through two cell adhesion molecules, alphavbeta3-integrin and CD44, to regulate cancer growth and metastasis. However, the sig ... Full text Link to item Cite

EF1A1-actin interactions alter mRNA stability to determine differential osteopontin expression in HepG2 and Hep3B cells.

Journal Article Exp Cell Res · January 15, 2009 Cancer progression depends on an accumulation of metastasis-supporting physiological changes which are regulated by cell signaling molecules. One such molecule, osteopontin (OPN), is a secreted phosphoprotein which mediates increased cellular migratory and ... Full text Link to item Cite

RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells.

Journal Article Mol Ther · January 2009 Osteopontin (OPN) is a secreted phosphoprotein which mediates tumorigenesis, local growth, and metastasis in a variety of cancers. It is a potential therapeutic target for the regulation of cancer metastasis. RNA aptamer technology targeting OPN may repres ... Full text Link to item Cite

Humoral Rejection after Liver Transplantation.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · January 1, 2009 Link to item Cite

Regionalization of hepatic resections is associated with increasing disparities among some patient populations in use of high-volume providers.

Journal Article J Am Coll Surg · December 2008 BACKGROUND: The goal of our study was to determine the temporal trends in provider volume for liver resection procedures. STUDY DESIGN: The Nationwide Inpatient Sample database for 1988 through 2003 was used to determine temporal trends in hospital and sur ... Full text Link to item Cite

"Ghost" publications among applicants to a general surgery residency program.

Journal Article J Am Coll Surg · October 2008 OBJECTIVE: To determine the incidence of potentially fraudulent (or "ghost") publications in applications to a general surgery residency program. METHODS: Electronic Residency Application Services applications submitted in 2005 to the general surgery resid ... Full text Link to item Cite

Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene.

Journal Article J Biol Chem · September 12, 2008 The local structural properties and spatial conformations of chromosomes are intimately associated with gene expression. The spatial associations of critical genomic elements in inducible nitric-oxide synthase (iNOS) transcription have not been previously ... Full text Link to item Cite

Relationship between provider volume and outcomes for orthotopic liver transplantation.

Journal Article J Gastrointest Surg · September 2008 INTRODUCTION: Recent data suggests that the previously demonstrable relationship between hospital volume and outcomes for liver transplant procedures may no longer exist. Furthermore, to our knowledge, no study has been published examining whether individu ... Full text Link to item Cite

Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis.

Journal Article Surgery · August 2008 BACKGROUND: Osteopontin (OPN) represses inducible nitric oxide synthase (iNOS) expression by increasing ubiquitin (Ub)-proteasome degradation of Stat1, a critical transcription factor for iNOS expression. We investigated the in vivo relevance of our findin ... Full text Link to item Cite

RNA stability regulates differential expression of the metastasis protein, osteopontin, in hepatocellular cancer.

Journal Article Surgery · June 2008 BACKGROUND: Osteopontin (OPN) is a potential therapeutic target in hepatocellular carcinoma (HCC), because it is a critical mediator of metastatic function. The molecular mechanisms that determine expression of OPN in HCC, however, are unknown. In this stu ... Full text Link to item Cite

Influence of long chain polyunsaturated fatty acids and ornithine concentrations on complications after renal transplant.

Journal Article Exp Clin Transplant · June 2008 OBJECTIVES: The present study, registered at clinicaltrials.gov with the unique registration number NCT00560014, sought to evaluate the relations between fatty acid concentrations in red blood cells or plasma and amino acid concentrations in plasma on reje ... Link to item Cite

Functional analysis of tumor metastasis: Modeling colon cancer

Journal Article Oncology Reviews · April 1, 2008 The primary cause of death from colon cancer results from metastases that withstand conventional therapy and escape locoregional control. The molecular regulation of the tumor cell's acquired ability for invasion and metastasis is still not completely unde ... Full text Cite

Workforce projections for hepato-pancreato-biliary surgery.

Journal Article J Am Coll Surg · April 2008 BACKGROUND: We wanted to determine whether current levels of fellowship training in hepato-pancreato-biliary (HPB) surgery will be sufficient to meet demand for HPB procedures in 2020. STUDY DESIGN: The Nationwide Inpatient Sample database for 1988 through ... Full text Link to item Cite

Osteopontin: regulation in tumor metastasis.

Journal Article Cancer Metastasis Rev · March 2008 Osteopontin is a secreted phosphoprotein that has been implicated as an important mediator of tumor metastasis and has been investigated for use as a biomarker for advanced disease and as a potential therapeutic target in the regulation of cancer metastasi ... Full text Link to item Cite

The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer.

Journal Article Dig Dis Sci · February 2008 Rho family GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. To evaluate the role of these GTPases in colorectal cancer, the protein expression levels and activities of the ... Full text Link to item Cite

Supply and demand for liver transplant surgery: are we training enough surgeons?

Journal Article HPB (Oxford) · 2008 The purpose of our study is to determine whether the current level of transplant fellow training is sufficient to meet the future demand for liver transplantation in the United States. Historical data from the Nationwide Inpatient Samples (NIS) for the yea ... Full text Link to item Cite

Little science, big science: strategies for research portfolio selection in academic surgery departments.

Journal Article Ann Surg · December 2007 OBJECTIVE: To evaluate National Institutes of Health (NIH) funding for academic surgery departments and to determine whether optimal portfolio strategies exist to maximize this funding. SUMMARY BACKGROUND DATA: The NIH budget is expected to be relatively s ... Full text Link to item Cite

Extended hepatic resection for gallbladder cancer.

Journal Article Am J Surg · September 2007 BACKGROUND: Although radical cholecystectomy is the standard of care for gallbladder cancers that invade perimuscular connective tissue or perforate visceral peritoneum, the role of extended right hepatectomy in achieving negative resection margins is not ... Full text Link to item Cite

Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells.

Journal Article Neoplasia · September 2007 BACKGROUND: Osteopontin (OPN) is a secreted glycoprotein that mediates cell-matrix interactions and cellular signaling by binding with integrin (primarily alpha(v)beta(3)) and CD44 receptors. OPN regulates cell adhesion, chemotaxis, macrophage-directed IL- ... Full text Link to item Cite

Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells.

Journal Article Surgery · August 2007 BACKGROUND: Osteopontin (OPN) mediates cancer metastasis. Mechanisms regulating OPN expression in human colorectal cancer are unknown. Using SW480 colon adenocarcinoma cells, we hypothesized that transcription determines OPN expression. METHODS: SW480 cons ... Full text Link to item Cite

Stat1 acetylation inhibits inducible nitric oxide synthase expression in interferon-gamma-treated RAW264.7 murine macrophages.

Journal Article Surgery · August 2007 BACKGROUND: We hypothesized that acetylation of the Stat1 regulates interferon-gamma (IFN-gamma) mediated macrophage expression of inducible nitric oxide synthase (iNOS). METHODS: RAW 264.7 iNOS expression was induced with IFN-gamma. Deacetylase inhibitors ... Full text Link to item Cite

Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cells.

Journal Article Cancer Res · May 1, 2007 Osteopontin is a glycoprotein that has been linked to metastatic function in breast, lung, and prostate cancers. However, the mechanism by which osteopontin acts to induce metastatic properties is largely unknown. One intriguing feature of osteopontin is t ... Full text Link to item Cite

Characterization of the PC4 binding domain and its interactions with HNF4alpha.

Journal Article J Biochem · May 2007 In the presence of oxidative stress, the hepatocellular inflammatory-redox (IR) state upregulates inducible nitric oxide synthase (iNOS) expression as an anti-oxidant function. In IL-1beta and peroxide treated hepatocytes, we have identified hepatocyte nuc ... Full text Link to item Cite

Intra-operative aprotinin in liver transplant and renal dysfunction.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 1, 2007 Link to item Cite

Resection of noncolorectal nonneuroendocrine liver metastases: a comparative analysis.

Journal Article J Am Coll Surg · March 2007 BACKGROUND: Although established for metastatic colorectal (CR) and neuroendocrine (NE) malignancies, the role of partial hepatectomy in management of metastases from other primaries (NCRNE) is not well-defined. STUDY DESIGN: The objective of this retrospe ... Full text Link to item Cite

Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages.

Journal Article J Immunol · February 1, 2007 In systemic inflammation induced by endotoxin (LPS), the macrophage produces the majority of the circulating NO metabolites. However, while the molecular pathways which up-regulate iNOS expression have been extensively studied in the macrophage, little is ... Full text Link to item Cite

Financial Considerations

Journal Article · January 1, 2007 Full text Cite

Temporal trends in early clinical outcomes and health care resource utilization for liver transplantation in the United States.

Journal Article J Gastrointest Surg · January 2007 INTRODUCTION: Procedures such as liver transplantation, which entail large costs while benefiting only a small percentage of the population, are being increasingly scrutinized by third-party payors. The purpose of our study was to conduct a longitudinal an ... Full text Link to item Cite

Renal function with cyclosporine C2 monitoring, enteric-coated mycophenolate sodium and basiliximab: a 12-month randomized trial in renal transplant recipients.

Journal Article Clin Transplant · 2007 BACKGROUND: Cyclosporine exposure, as estimated by the area under the curve (AUC), predicts outcomes in renal transplantation. Cyclosporine concentration at two h post-dose (C(2)) has been shown to be the most reliable, single-point surrogate marker for AU ... Full text Link to item Cite

Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation.

Journal Article Surgery · August 2006 BACKGROUND: Interactions between tumor cells and their host environment can play a major role in regulating survival programs required for tumor progression. Osteopontin (OPN) is a glycophosphoprotein overexpressed by tumors, and is a key molecule for tumo ... Full text Link to item Cite

Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells.

Journal Article J Biol Chem · July 14, 2006 Osteopontin (OPN) is a sialic acid-rich phosphoprotein secreted by a wide variety of cancers. We have shown previously that OPN is necessary for mediating hepatic metastasis in CT26 colorectal cancer cells. Although a variety of stimuli can induce OPN, the ... Full text Link to item Cite

Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells.

Journal Article Carcinogenesis · June 2006 Metastasis-supporting physiological alterations are regulated by cell signaling molecules, which target signal transduction pathways and gene expression. Osteopontin (OPN) overexpression may represent a key molecular event in cancer metastasis. In this stu ... Full text Link to item Cite

Productivity measures associated with a patient access initiative.

Journal Article Ann Surg · May 2006 OBJECTIVE: To assess financial performance associated with a patient 7-day access initiative. BACKGROUND DATA: Patient access to clinical services is frequently an obstacle at academic medical centers. Conflicting surgeon priorities among academic, clinica ... Full text Link to item Cite

Insertion, reduction, and carbon-carbon coupling induced by monomeric aluminum hydride compounds bearing substituted pyrrolyl ligands.

Journal Article Chemistry (Weinheim an der Bergstrasse, Germany) · April 2006 A monomeric aluminum hydride complex bearing substituted pyrrolyl ligands, AlH[C(4)H(3)N(CH(2)NMe(2))-2](2) (1), was synthesized and structurally characterized. To further confirm the presence of Al--H bonds, the compound AlD[C(4)H(3)N(CH(2)NMe(2))-2](2) ( ... Cite

Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity.

Journal Article Biochem J · March 1, 2006 In IL-1beta (interleukin 1beta)-stimulated rat hepatocytes exposed to superoxide, we have previously identified an IRX (inflammatory redox)-sensitive DR1 [direct repeat of RG(G/T)TCA with one base spacing] cis-acting activator element (nt -1327 to -1315) i ... Full text Link to item Cite

Predictive indices of morbidity and mortality after liver resection.

Journal Article Ann Surg · March 2006 OBJECTIVE: To determine if use of Model for End-Stage Liver Disease (MELD) scores to elective resections accurately predicts short-term morbidity or mortality. SUMMARY BACKGROUND DATA: MELD scores have been validated in the setting of end-stage liver disea ... Full text Link to item Cite

Scheduling the resident 80-hour work week: an operations research algorithm.

Journal Article Curr Surg · 2006 OBJECTIVE: The resident 80-hour work week requires that programs now schedule duty hours. Typically, scheduling is performed in an empirical "trial-and-error" fashion. However, this is a classic "scheduling" problem from the field of operations research (O ... Full text Link to item Cite

Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation.

Journal Article Clin Transplant · 2006 BACKGROUND: Although innate immunity is crucial to host defense against pathogens, the extent to which innate immune mechanisms participate in the rejection of allogenic tissues in humans is unknown. We hypothesize that activation of innate immunity throug ... Full text Link to item Cite

Perioperative management of special populations: immunocompromised host (cancer, HIV, transplantation).

Journal Article Surg Clin North Am · December 2005 Optimal perioperative care of the immunocompromised patient requires an understanding of the consequences of disease-specific pharmacologic therapies. The toxicity profile of these therapies can strongly influence the decision algorithms for delivering car ... Full text Link to item Cite

Case 23-2005: a man with a mass in the liver.

Journal Article N Engl J Med · November 17, 2005 Link to item Cite

Obesity predicts increased overall complications following pancreas transplantation.

Journal Article Transplant Proc · October 2005 PURPOSE: We sought to evaluate the role of recipient body mass index (BMI) on postoperative complications in patients receiving pancreas transplants. METHODS: A single-institution retrospective study of 145 consecutive patients undergoing either simultaneo ... Full text Link to item Cite

Half-life analysis of pancreas and kidney transplants.

Journal Article Transplantation · July 27, 2005 Although graft and patient survival data are available for pancreas and kidney transplants, they are rarely reported in terms of half-life. Our aim was to determine whether a more relevant measure of outcome is patient and allograft half-life. Using the da ... Full text Link to item Cite

Phenanthroindolizidine alkaloids from the stems of Ficus septica.

Journal Article Journal of natural products · July 2005 In addition to six known phenanthroindolizidine alkaloids, eight new alkaloids, namely, ficuseptines B-D (1-3), 10R,13aR-tylophorine N-oxide (4), 10R,13aR-tylocrebrine N-oxide (5), 10S,13aR-tylocrebrine N-oxide (6), 10S,13aR-isotylocrebrine N-oxide (7), an ... Cite

Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4.

Journal Article Surgery · July 2005 BACKGROUND: Redox-mediated upregulation of transcription of hepatocyte inducible nitric oxide synthase (iNOS) requires hepatocyte nuclear factor IV-alpha (HNF-4alpha). In this setting, PC4 is often isolated with HNF-4alpha in DNA-protein pull-down studies. ... Full text Link to item Cite

Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-U and -A/B in endotoxin-mediated macrophage expression of osteopontin.

Journal Article J Immunol · July 1, 2005 Osteopontin (OPN) is a highly hydrophilic and negatively charged sialoprotein of approximately 298 amino acids with diverse regulatory functions, including cell adhesion and migration, tumor growth and metastasis, atherosclerosis, aortic valve calcificatio ... Full text Link to item Cite

Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells.

Journal Article Dig Dis Sci · July 2005 Our objective was to delineate the role of nitric oxide (NO) in osteopontin (OPN)-associated metastatic properties in HepG2 cells. OPN is the major phosphoprotein secreted by malignant cells in patients with advanced metastatic cancer, is frequently overex ... Full text Link to item Cite

Isolation of a natural antioxidant, dehydrozingerone from Zingiber officinale and synthesis of its analogues for recognition of effective antioxidant and antityrosinase agents.

Journal Article Archives of pharmacal research, Korea (South) · May 2005 In the present study, the antioxidative and inhibitory activity of Zingiber officinale Rosc. rhizomes-derived materials (on mushroom tyrosinase) were evaluated. The bioactive components of Z. officinale rhizomes were characterized by spectroscopic analysis ... Cite

Gastrointestinal hemorrhage due to complicated gastroduodenal ulcer disease in liver transplant patients taking sirolimus.

Journal Article Clin Transplant · April 2005 Sirolimus is emerging as a popular immunosuppressive agent for patients undergoing solid organ and pancreatic cell transplantation. Here, we report the clinical courses of three patients receiving sirolimus who developed aggressive gastroduodenal ulcer dis ... Full text Link to item Cite

Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis.

Journal Article Carcinogenesis · April 2005 Hepatic metastasis is a primary cause for failure of locoregional therapy in colorectal cancer. Increased expression of osteopontin (OPN), a ligand for alpha(v)beta3 integrin and CD44 receptors, is associated with metastasis in several types of cancer. How ... Full text Link to item Cite

Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages.

Journal Article Nitric Oxide · March 2005 Nitric oxide (NO) is an omnipresent regulator of cell function in a variety of physiologic and pathophysiologic states. In part, NO exerts its actions by S-nitrosylation of target thiols, primarily in cysteine residues. Delineating the functional correlate ... Full text Link to item Cite

The current status of living donor liver transplantation.

Journal Article Curr Probl Surg · March 2005 In response to the critical organ shortage, transplant professionals have utilized living donors in an attempt to decrease the mortality rate associated with waiting on the liver transplant list. Although the surgical techniques were first utilized clinica ... Full text Link to item Cite

Acute kidney transplant failure following transurethral bladder polyp fulguration.

Journal Article J Natl Med Assoc · March 2005 Ureteral obstruction and anastomotic leak represent the most common urologic complications of kidney transplantation. Delay in diagnosis or treatment can lead to allograft loss. Obstruction of the ureter occurs in 2% of kidney transplant recipients. Althou ... Link to item Cite

Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells.

Journal Article The Journal of biological chemistry · December 2004 Quercetin, a ubiquitous bioactive plant flavonoid, has been shown to inhibit the proliferation of cancer cells. However, the regulation of survivin and p53 on the quercetin-induced cell growth inhibition and apoptosis in cancer cells remains unclear. In th ... Cite

Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior.

Journal Article J Biol Chem · November 5, 2004 Cancer progression depends on an accumulation of metastasis-supporting cell signaling molecules, which target signal transduction pathways and, ultimately, gene expression. One such molecule, osteopontin (OPN), represents a key molecular signaling event in ... Full text Link to item Cite

Terpenoids of Aristolochia and their biological activities.

Journal Article Natural product reports · October 2004 Aristolochia is an important genus widely used in traditional medicine. During the past two decades, this genus has attracted much interest and has been the subject of numerous chemical and pharmacological studies. It is a rich source of aristolochic acids ... Cite

New neolignans from Spiraea formosana.

Journal Article Chemical & pharmaceutical bulletin · October 2004 Phytochemical investigation on the ethanol extract from the stems of Spiraea formosana has resulted in the isolation of four new neolignans, named spiraformin-A, -B, -C and -D (1-4), together with thirty five known compounds. Their structures were establis ... Cite

The role of Osteopontin in tumor metastasis.

Journal Article J Surg Res · October 2004 Osteopontin (OPN) is a glyco-phosphoprotein that is expressed and secreted by numerous human cancers. OPN functions in cell adhesion, chemotaxis, macrophage-directed interleukin-10 (IL-10) suppression, stress-dependent angiogenesis, prevention of apoptosis ... Full text Link to item Cite

A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line.

Journal Article Biochem Biophys Res Commun · September 3, 2004 Osteopontin (OPN) is a highly hydrophilic and negatively charged sialoprotein of approximately 298 amino acids which is an important mediator of tumor metastatic behavior. We have previously demonstrated that endotoxin-dependent OPN gene transcription is r ... Full text Link to item Cite

An overview of genomic data analysis.

Journal Article Surgery · September 2004 Full text Link to item Cite

Osteopontin increases CD44 expression and cell adhesion in RAW 264.7 murine leukemia cells.

Journal Article Immunol Lett · August 15, 2004 BACKGROUND: Osteopontin (OPN) is an inducible cell attachment protein which binds alphavbeta3-integrin and CD44 receptors to promote tumor metastasis. We hypothesized that OPN alters expression of its CD44 receptor to promote neoplastic cell migration. MET ... Full text Link to item Cite

The parkinsonian phenotype of spinocerebellar ataxia type 3 in a Taiwanese family.

Journal Article Parkinsonism & related disorders · August 2004 We report a parkinsonian phenotype of spinocerebellar ataxia type 3 (SCA3) in three female sibs from one Taiwanese family, found in a genetic analysis of 60 patients from 49 families with familial parkinsonism. Initially, all three patients presented with ... Cite

Intraoperative fluid management during orthotopic liver transplantation.

Journal Article J Cardiothorac Vasc Anesth · August 2004 OBJECTIVE: To assess clinical safety of a low central venous pressure (CVP) fluid management strategy in patients undergoing liver transplantation. DESIGN: Retrospective record review comparing 2 transplant centers, one using the low CVP method and the oth ... Full text Link to item Cite

Determining benchmarks for evaluation and management coding in an academic division of general surgery.

Journal Article J Am Coll Surg · July 2004 BACKGROUND: Academic divisions of general surgery are facing ever-increasing financial pressures. Cost-cutting is a common approach to maintaining profitability, but strategies to increase revenue should not be ignored. One specific avenue for enhanced rev ... Full text Link to item Cite

Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells.

Journal Article The Journal of biological chemistry · May 2004 Survivin is expressed in most tumor cells and has been associated with both anti-apoptosis and mitotic progression. However, the mechanism of regulation of the survivin expression remains unclear. In this study we investigated the expression and regulation ... Cite

The role of recombinant lysine-plasminogen and recombinant urokinase and sulfur hexafluoride combination in inducing posterior vitreous detachment.

Journal Article Retina (Philadelphia, Pa.) · April 2004 PURPOSE: To determine the optimal method of generating plasmin in vitreous using recombinant lysine-plasminogen and recombinant urokinase and to determine its efficacy in inducing posterior vitreous detachment when combined with sulfur hexafluoride. METHOD ... Cite

S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages.

Journal Article J Biol Chem · March 19, 2004 Osteopontin (OPN) is a highly hydrophilic and negatively charged sialoprotein of approximately 298 amino acids that contains a Gly-Arg-Gly-Asp-Ser sequence. It is a secreted protein with diverse regulatory functions, including cell adhesion and migration, ... Full text Link to item Cite

Flavonoids and coumarins from Leaves of Phellodendron chinense.

Journal Article Planta medica · February 2004 Three new compounds, phellodensin G, phellodenols D and E have been isolated from the leaves of Phellodendron chinense Schneid (Rutaceae), together with thirteen known compounds. Their structures were established by means of spectroscopic analysis, includi ... Cite

Peroxide-mediated chromatin remodelling of a nuclear factor kappa B site in the mouse inducible nitric oxide synthase promoter.

Journal Article Biochem J · February 1, 2004 Hepatocyte expression of iNOS (inducible nitric oxide synthase) and synthesis of nitric oxide convey protective antioxidant functions in models of sepsis, shock and reperfusion. However, the underlying redox-sensitive mechanisms that regulate hepatocyte ex ... Full text Link to item Cite

Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia.

Journal Article Bioorganic & medicinal chemistry · February 2004 Sixty-five compounds were isolated from the roots of Eurycoma longifolia and characterized by comprehensive analyses of their 1D and 2D NMR, and mass spectral data. Among these isolates, four quassinoid diterpenoids were reported from natural sources for t ... Cite

The parkinsonian phenotype of spinocerebellar ataxia type 2.

Journal Article Archives of neurology · January 2004 BACKGROUND: We recently reported that spinocerebellar ataxia type 2 (SCA2) caused familial parkinsonism in 2 brothers with predominant symptoms of resting tremor, rigidity, and bradykinesia that responded to levodopa. OBJECTIVE: To investigate SCA2 as the ... Cite

The effect of indocyanine green pretreatment on the parameters of transscleral diode laser thermotherapy-induced threshold coagulation of the ciliary body.

Journal Article Lasers in surgery and medicine · 2004 BACKGROUND AND OBJECTIVE: To study the effect of indocyanine green (ICG) pretreatment on threshold parameters of transscleral diode laser thermotherapy-induced threshold coagulation of the ciliary body. The procedure was termed 'cyclothermotherapy' based o ... Cite

The alkaloids and other constituents from the root and stem of Aristolochia elegans.

Journal Article Bioorganic & medicinal chemistry · January 2004 Two new aristolactams, aristolactam E (1) and aristolactam-AIIIa-6-O-beta-D-glucoside (2), three novel benzoyl benzyltetrahydroisoquinoline ether N-oxide alkaloids, aristoquinoline A (3), aristoquinoline B (4), and aristoquinoline C (5), and a new biphenyl ... Cite

Flavonoids from Andrographis viscosula.

Journal Article Chemical & pharmaceutical bulletin · December 2003 Phytochemical investigation of the whole plant of Andrographis viscosula has led to the isolation of three new 2'-oxygenated flavonoids, (2R)-5-hydroxy-7,2',3'-trimethoxyflavanone (1), 7,2',5'-trimethoxyflavone (2), 5,7,2',3'-tetramethoxyflavone (3), and e ... Cite

Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells.

Journal Article Carcinogenesis · December 2003 The interaction of osteopontin (OPN) with CD44 and alphavbeta3-integrin has been implicated in numerous signal transduction pathways that may promote cancer metastasis. CD44v6 is a splice variant of CD44 which has been identified as a marker of cancer prog ... Full text Link to item Cite

Optimization of operating room allocation using linear programming techniques.

Journal Article J Am Coll Surg · December 2003 BACKGROUND: New and innovative approaches must be used to rationally allocate scarce resources such as operating room time while simultaneously optimizing the associated financial return. In this article we use the technique of linear programming to optimi ... Full text Link to item Cite

Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia.

Journal Article Journal of natural products · October 2003 Three new [n-pentyl beta-carboline-1-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known beta-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were de ... Cite

Osteopontin inhibits expression of cytochrome c oxidase in RAW 264.7 murine macrophages.

Journal Article Biochem Biophys Res Commun · September 12, 2003 Osteopontin (OPN) functions as both a cell attachment protein and a cytokine that signals through two CAM molecules: alpha(v)beta(3)-integrin and CD44. OPN initiates a number of signal transduction pathways that control cell survival, proliferation, and mi ... Full text Link to item Cite

Constituents from the leaves of Phellodendron amurense var. wilsonii and their bioactivity.

Journal Article Journal of natural products · September 2003 Two new dihydroflavonols, phellodensin-A (1) and phellodensin-C (2); three new coumarins, phellodenol-A (3), phellodenol-B (4), and phellodenol-C (5); one new chlorophyll, phellophyll-a (6); and one new phenyllactate, (2R)-sodium 3-phenyllactate (7), in ad ... Cite

The effect of intraoperative retinal manipulation on the underlying retinal pigment epithelium: an experimental study.

Journal Article Retina (Philadelphia, Pa.) · August 2003 PURPOSE: Retinal pigment epithelial changes described after vitreoretinal surgery may result from localized compression injury caused by intentional or inadvertent contact with vitreoretinal instruments. The authors evaluated these changes resulting from m ... Cite

Cytotoxic anthraquinones from the stems of Rubia wallichiana Decne.

Journal Article Chemical & pharmaceutical bulletin · August 2003 From the stems of Rubia wallichiana DECNE, thirty-four structurally related compounds were isolated and identified. Three of them, namely rubiawallin-A (1), -B (2), and -C (3), constitute the first report of their occurrence from the natural source. Their ... Cite

Acetophenone derivatives from Acronychia pedunculata.

Journal Article Journal of natural products · July 2003 Chemical investigation on the stem and root bark of Acronychia pedunculata has resulted in the isolation of five new acetophenones, namely, acronyculatins A (1), B (2), C (3), D (4), and E (5). The structures of these metabolites were established on the ba ... Cite

Transpupillary thermotherapy threshold parameters: effect of indocyanine green pretreatment.

Journal Article Retina (Philadelphia, Pa.) · June 2003 PURPOSE: To evaluate the effect of combined treatment with systemic indocyanine green (ICG) on threshold fluence levels of transpupillary thermotherapy (TTT) in rabbits. METHODS: Four pigmented rabbits and 13 nonpigmented rabbits were studied. TTT was perf ... Cite

Transpupillary thermotherapy threshold parameters: funduscopic, angiographic, and histologic findings in pigmented and nonpigmented rabbits.

Journal Article Retina (Philadelphia, Pa.) · June 2003 PURPOSE: To evaluate the effect of pigmentation on threshold fluence levels, needed to produce visible and angiographic lesions, of transpupillary thermotherapy (TTT) in rabbits. METHODS: Six pigmented and nine nonpigmented rabbits underwent TTT with an 81 ... Cite

Beneficial effect of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection.

Journal Article Transplantation · May 15, 2003 BACKGROUND: Acute humoral rejection (AHR) has been associated with enhanced graft loss. Our study compared the renal allograft survival of patients with AHR treated with plasmapheresis (PP) and intravenous immunoglobulin (IVIG) with allograft survival in p ... Full text Link to item Cite

Tolerance and the "Holy Grail" of transplantation.

Journal Article J Surg Res · May 1, 2003 Advances in transplantation biology have greatly improved patient outcomes following transplant surgery. However, generalized immunosuppression remains the Achilles heel of modern transplantation surgery with its associated infectious and neoplastic morbid ... Full text Link to item Cite

De-novo cholangiocarcinoma in the setting of recurrent primary sclerosing cholangitis following liver transplant.

Journal Article Am J Transplant · May 2003 Orthotopic liver transplantation is the only definitive therapeutic option in patients with primary sclerosing cholangitis (PSC) and end-stage liver disease. However, PSC recurs in up to 20% of patients transplanted for this indication. To date, no patient ... Full text Link to item Cite

The role of scleral buckle in experimental posterior penetrating eye injury.

Journal Article Retina (Philadelphia, Pa.) · April 2003 PURPOSE: Although episcleral buckles are frequently placed as an additional procedure to vitreoretinal surgery, little is known about their independent effect after ocular trauma. The authors created a posterior penetrating ocular injury model to evaluate ... Cite

Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes.

Journal Article Am J Physiol Cell Physiol · April 2003 Featured Publication Nitric oxide (NO), endogenously synthesized by inducible NO synthase (iNOS), serves antioxidant and antiapoptotic functions in settings characterized by oxidative stress and proinflammatory cytokines such as sepsis and shock. However, the redox-sensitive m ... Full text Link to item Cite

Emergencies after liver transplantation.

Journal Article Semin Gastrointest Dis · April 2003 Liver transplantation has become the procedure of choice for a wide variety of patients with end-stage liver disease. Perioperative morbidity and mortality have decreased dramatically over the past two decades, and superior graft and patient survival rates ... Link to item Cite

Constituents from the root and stem of Aristolochia elegans.

Journal Article J Nat Prod · November 2002 Featured Publication Four new tetralones, aristelegone-A (1), aristelegone-B (2), aristelegone-C (3), and aristelegone-D (4); one new isoquinoline, pericampylinone-A (5); four new biphenyl ethers, aristogin-A (6), aristogin-B (7), aristogin-D (8), and aristogin-E (9); three ne ... Full text Link to item Cite

An examination of factors predicting prioritization for liver transplantation.

Journal Article Liver Transpl · October 2002 Featured Publication With the recent transition of the liver transplant allocation system to the Model for End-Stage Liver Disease, a major change is its reliance entirely on objective criteria. In previous reports, potential donor families and members of the transplant commun ... Full text Link to item Cite

Surgical techniques in right laparoscopic donor nephrectomy.

Journal Article J Am Coll Surg · July 2002 Featured Publication Full text Link to item Cite

MR angiography and preoperative evaluation for laparoscopic donor nephrectomy.

Journal Article AJR Am J Roentgenol · June 2002 Featured Publication OBJECTIVE: The purpose of our study was to evaluate the effectiveness of gadolinium-enhanced MR imaging in imaging arterial, venous, and ureteric anatomy in a group of potential laparoscopic renal donors and to compare our findings with those established a ... Full text Link to item Cite

Endotoxin-stimulated nitric oxide production inhibits expression of cytochrome c oxidase in ANA-1 murine macrophages.

Journal Article J Immunol · May 1, 2002 Featured Publication In endotoxin (LPS)-mediated states of sepsis, inducible NO synthase expression and NO production are associated with molecular regulatory functions that determine the host inflammatory response. NO inhibits cellular respiration and mitochondrial electron t ... Full text Link to item Cite

Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription.

Journal Article J Biol Chem · February 15, 2002 Featured Publication The underlying redox-sensitive mechanisms that regulate hepatocyte expression of inducible nitric-oxide synthase (iNOS) and its antioxidant functions are largely unknown. We have demonstrated previously that oxidative stress induced by benzenetriol-mediate ... Full text Link to item Cite

Pharmacokinetics and biochemical effects of hepapoietin in patients with chronic liver disease.

Journal Article Alimentary pharmacology & therapeutics · February 2002 Featured Publication BackgroundHepapoietin is a naturally occurring cytokine that promotes hepatocyte growth. Animal studies have suggested that hepapoietin and hepatocyte growth factor have a potential role in the prevention and management of liver diseases. However, ... Full text Cite

Nitric oxide is necessary for CC-class chemokine expression in endotoxin-stimulated ANA-1 murine macrophages.

Journal Article Immunol Lett · January 1, 2002 Featured Publication The production of nitric oxide (NO) in response to endotoxin (LPS)-stimulation is associated with a myriad of NO-dependent regulatory functions. The study of NO-dependent genetic programs in the setting of endotoxin stimulation can be aided by determinatio ... Full text Link to item Cite

Nitric oxide inhibits expression of cytochrome B in endotoxin-stimulated murine macrophages.

Journal Article Biochem Biophys Res Commun · December 21, 2001 Featured Publication In LPS-mediated states of sepsis, inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production inhibit cellular respiration and mitochondrial electron transport. NO has been demonstrated to inhibit mitochondrial respiration by nitrosy ... Full text Link to item Cite

Transplantation of hepatitis C-positive livers in hepatitis C-positive patients is equivalent to transplanting hepatitis C-negative livers.

Journal Article Liver Transpl · September 2001 Featured Publication A significant number of patients with end-stage liver disease secondary to hepatitis C die of disease-related complications. Liver transplantation offers the only effective alternative. Unfortunately, organ demand exceeds supply. Consequently, some transpl ... Full text Link to item Cite

Expanded criteria donors/high risk recipients is not always cheaper than hemodialysis.

Journal Article Transplantation · August 15, 2001 Featured Publication Full text Link to item Cite

Candida fasciitis following renal transplantation.

Journal Article Transplantation · August 15, 2001 Featured Publication BACKGROUND: We describe a rare case of necrotizing fasciitis involving Candida albicans, an organism that has been reported to have a minimal potential for invasive soft tissue infection. In this case, immunosuppression, chronic renal failure, and a histor ... Full text Link to item Cite

Outcome of extra-anatomic vascular reconstruction in orthotopic liver transplantation.

Journal Article Am J Surg · August 2001 Featured Publication BACKGROUND: Portal venous and hepatic arterial reconstruction are critical to successful outcomes in orthotopic liver transplantation (OLT). With portal vein thrombosis or inadequate hepatic arterial inflow, extra-anatomic vascular reconstruction is requir ... Full text Link to item Cite

Reconsideration of HIV as a contraindication to transplantation.

Journal Article Transplantation · June 15, 2001 Featured Publication Full text Link to item Cite

Transplantation in the HIV+ patient.

Journal Article Am J Transplant · May 2001 Featured Publication The historical exclusion from transplantation of HIV-infected people was based on the logical premise that immunosuppression required for organ transplantation would exacerbate an immunocompromised state. However, the prognosis for people with HIV infectio ... Full text Link to item Cite

Dobutamine stress echocardiography for orthotopic liver transplant evaluation.

Journal Article Transplantation · March 27, 2001 Featured Publication Full text Link to item Cite

Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages.

Journal Article J Immunol · January 15, 2001 Featured Publication In a system of endotoxin (LPS)-mediated NO production in ANA-1 murine macrophages, suppression subtractive hybridization was used to identify genes up-regulated by NO. Osteopontin (OPN), a secreted acidic phosphoprotein that binds to a cell surface RGD int ... Full text Link to item Cite

Pulmonary expression of iNOS and HO-1 protein is upregulated in a rat model of prehepatic portal hypertension.

Journal Article Dig Dis Sci · December 2000 Portal hypertension is associated with a wide range of pulmonary pathophysiologies, ranging from portopulmonary hypertension to hepatopulmonary syndrome. Although the clinical and pathological features of pulmonary dysfunction in this setting have been ext ... Full text Link to item Cite

Laparoscopic donor nephrectomy: pro.

Journal Article Transplantation · November 27, 2000 Full text Link to item Cite

Endotoxin and NO induce MIP-1gamma gene transcription in ANA-1 murine macrophages.

Journal Article Biochem Biophys Res Commun · November 2, 2000 The host response to gram-negative endotoxin is characterized by an influx of inflammatory cells into host tissues, mediated in part by localized production of chemokines. In this study, using subtractive suppression hybridization analysis, we demonstrate ... Full text Link to item Cite

Nitric oxide-dependent ribosomal RNA cleavage is associated with inhibition of ribosomal peptidyl transferase activity in ANA-1 murine macrophages.

Journal Article J Immunol · October 1, 2000 NO can regulate specific cellular functions by altering transcriptional programs and protein reactivity. With respect to global cellular processes, NO has also been demonstrated to inhibit total protein synthesis and cell proliferation. The underlying mech ... Full text Link to item Cite

Use of aerosolized inhaled epoprostenol in the treatment of portopulmonary hypertension.

Journal Article Transplantation · August 15, 2000 BACKGROUND: Portopulmonary hypertension is a known complication in the liver transplant candidate. Intravenous epoprostenol has been demonstrated to decrease pulmonary artery pressures and possibly remodel right ventricle geometry. METHODS: In this report, ... Full text Link to item Cite

Intraoperative use of inhaled PGI(2) for acute pulmonary hypertension and right ventricular failure.

Journal Article Anesth Analg · August 2000 Inhaled prostacyclin (PGI(2)) can be used as an effective pulmonary vasodilator intraoperatively to treat pulmonary hypertension and impending right ventricular failure. ... Full text Link to item Cite

Laparoscopic donor nephrectomy increases the supply of living donor kidneys: a center-specific microeconomic analysis.

Journal Article Transplantation · May 27, 2000 BACKGROUND: A tenet of microeconomics is that new technology will shift the supply curve to the right. Laparoscopic donor nephrectomy (LDN) is a new technique for removal of living donor kidneys. Centers performing this procedure have noted an increased nu ... Full text Link to item Cite

Laparoscopic donor nephrectomy with a 23-hour stay: a new standard for transplantation surgery.

Journal Article Ann Surg · May 2000 OBJECTIVE: To determine the outcomes associated with laparoscopic donor nephrectomy (LDN) performed as a 23-hour day surgery protocol. SUMMARY BACKGROUND DATA: Living donor renal transplantation is associated with immediate graft function and prolonged gra ... Full text Link to item Cite

Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene.

Journal Article Gastroenterology · March 2000 BACKGROUND & AIMS: Exposure to oxidative stress, as in states of shock, ischemia-reperfusion injury, or sepsis, commonly initiates a complex cellular cascade of interlocking redox modulatory systems that detoxify electrophiles. In interleukin 1beta (IL-1be ... Full text Link to item Cite

Outcome in recipients of dual kidney transplants: an analysis of the dual registry patients.

Journal Article Transplantation · January 27, 2000 BACKGROUND: A novel but controversial method to increase the utilization of aged donor kidneys is the transplantation of both kidneys as a dual transplant. Initial single-center reports demonstrated outcomes similar to single kidneys from younger donors. I ... Full text Link to item Cite

Outcomes of laparoscopic donor nephrectomy in obese patients.

Journal Article Transplantation · January 15, 2000 The applicability of laparoscopic donor nephrectomy (LDN) has not been assessed in the obese donor. We hypothesized that obesity is not a technical contraindication to LDN. From May 1998 to February 1999, 40 patients underwent LDN at the Georgetown Transpl ... Full text Link to item Cite

Retroperitoneal compartment syndrome after renal transplantation.

Journal Article Am Surg · January 2000 We report the case of a 21-year-old man with end-stage renal disease secondary to systemic lupus erythematosus who underwent living related renal transplantation and developed an extraperitoneal compartment syndrome postoperatively. ... Link to item Cite

Transverse hepatectomy for symptomatic polycystic liver disease.

Journal Article Liver · December 1999 Polycystic liver disease can result in massive enlargement of the liver with resultant debilitating symptoms of abdominal pain, chronic fatigue, and severely compromised functional status. Fenestration of hepatic cysts has been advocated as a treatment for ... Full text Link to item Cite

Is living donor nephrectomy a "23-hr stay" procedure?

Journal Article Transplantation · October 15, 1999 Full text Link to item Cite

Endotoxin-mediated nitric oxide synthesis inhibits IL-1beta gene transcription in ANA-1 murine macrophages.

Journal Article Am J Physiol · September 1999 On the basis of previous work demonstrating nitric oxide (NO)-mediated inhibition of nuclear factor-kappaB (NF-kappaB) DNA binding, we hypothesized that NO downregulates NF-kappaB-dependent interleukin-1beta (IL-1beta) production in an ANA-1 macrophage mod ... Full text Link to item Cite

Laparoscopic versus open donor nephrectomy: comparing ureteral complications in the recipients and improving the laparoscopic technique.

Journal Article Transplantation · August 27, 1999 BACKGROUND: Laparoscopic live donor nephrectomy (LDN) is a recently developed procedure, the performance of which needs to be studied. Given the reported advantages in the donors, this study looks at graft outcome and ureteral complications in recipients o ... Full text Link to item Cite

Redox regulation of the rat hepatocyte iNOS promoter.

Journal Article Surgery · August 1999 BACKGROUND: The purpose of this study was to define the redox sensitive cis-acting transcriptional mechanisms that regulate inducible nitric oxide synthase (iNOS) promoter function in the hepatocyte. METHODS: Clonal deletion constructs of the rat hepatocyt ... Link to item Cite

Portopulmonary hypertension and the liver transplant candidate.

Journal Article Transplantation · April 27, 1999 The management of the liver transplant (OLT) candidate with portopulmonary hypertension (PPHTN) has dramatically changed in the past 3 years. Careful preoperative evaluation with functional characterization of right ventricular function plays a critical ro ... Full text Link to item Cite

Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages.

Journal Article J Immunol · April 1, 1999 Nitric oxide (NO) regulates cellular function, in part, by S-nitrosylating active site thiol groups of proteins. Ex vivo S-nitrosylation of NF-kappa B p50 significantly decreases its capacity for DNA binding. To determine the cellular relevance of this obs ... Link to item Cite

Reduced transfusion requirements during major hepatic resection with use of intraoperative isovolemic hemodilution.

Journal Article Am J Surg · December 1998 BACKGROUND: Allogeneic blood transfusion during liver resection for malignancies has been associated with an increased incidence of tumor recurrence and decreased survival in some series. Isovolemic hemodilution (IH) has been utilized in cardiac, orthopedi ... Full text Link to item Cite

Laparoscopic living donor nephrectomy and multiple renal arteries.

Journal Article Am J Surg · December 1998 BACKGROUND: Laparoscopic donor nephrectomy (LDN) is a new technique. While the short-term recipient renal function is equivalent to that of the traditional open nephrectomy (ODN), long-term function and potential exclusion criteria, such as the presence of ... Full text Link to item Cite

Acute pancreatitis and fulminant hepatic failure.

Journal Article J Am Coll Surg · November 1998 BACKGROUND: The association of acute pancreatitis with fulminant hepatic failure (FHF) was first recognized in 1973. Since then, few studies have described the clinical profile of the FHF patient with acute pancreatitis. Identification of the distinguishin ... Full text Link to item Cite

Differential effects of nitric oxide-mediated S-nitrosylation on p50 and c-jun DNA binding.

Journal Article Surgery · August 1998 BACKGROUND: Nitric oxide (NO) regulates a variety of cellular functions. One mechanism by which NO may exert its influence is through formation of S-nitrosothiols at critical thiol residues in protein-active sites, including those of nuclear protein transc ... Link to item Cite

Dobutamine stress echocardiography for preoperative cardiac risk stratification in patients undergoing orthotopic liver transplantation.

Journal Article Liver Transpl Surg · July 1998 This study attempts to evaluate the efficacy of dobutamine stress echocardiography for preoperative cardiac risk stratification in patients undergoing orthotopic liver transplantation. Two hundred twenty consecutively submitted patients were evaluated in p ... Full text Link to item Cite

The clinical implications of hypophosphatemia following major hepatic resection or cryosurgery.

Journal Article Arch Surg · July 1998 OBJECTIVES: To determine the incidence and predisposing factors leading to postoperative hypophosphatemia after major hepatic surgery and the consequences of this electrolyte abnormality. DESIGN: A retrospective study. SETTING: A university tertiary care r ... Full text Link to item Cite

Epstein-Barr virus-related posttransplantation lymphoproliferative disorder involving pancreas allografts: histological differential diagnosis from acute allograft rejection.

Journal Article Hum Pathol · June 1998 The clinical and pathological features of acute pancreas allograft rejection and involvement of the graft by posttransplantation lymphoproliferative disorders (PTLD) overlap. Because the treatment is diametrically opposite in these two types of lesions, an ... Full text Link to item Cite

Apoptosis and hepatic allograft reperfusion injury.

Journal Article Clin Transplant · June 1998 Necrosis and apoptosis are distinct, but nonexclusive mechanisms of cell death. Until recently, investigators have focused upon necrosis as the sine qua non of lethal cell injury. Specifically, within the realm of liver transplantation, preservation strate ... Link to item Cite

Interleukin 1beta-stimulated production of nitric oxide in rat hepatocytes is mediated through endogenous synthesis of interferon gamma.

Journal Article Hepatology · March 1998 The multiple interlocking regulatory mechanisms that underlie induction of hepatocyte inducible nitric oxide synthase (iNOS) expression are largely unknown. Although previous work has indicated the requirement for multiple proinflammatory cytokines to indu ... Full text Link to item Cite

Successful use of chronic epoprostenol as a bridge to liver transplantation in severe portopulmonary hypertension.

Journal Article Transplantation · February 27, 1998 BACKGROUND: Portopulmonary hypertension, defined as mean pulmonary artery pressure >25 mmHg in the presence of a normal pulmonary capillary wedge pressure and portal hypertension, is a known complication of end-stage liver disease that has been associated ... Full text Link to item Cite

Mycophenolate mofetil reduces the risk of acute rejection less in African-American than in Caucasian kidney recipients.

Journal Article Transplantation · January 27, 1998 BACKGROUND: Multicenter clinical trials have shown that mycophenolate mofetil (MMF) reduces the risk of acute rejection, but it is unknown whether African-Americans constitute a subgroup of recipients less likely to benefit from MMF. METHODS: This study co ... Full text Link to item Cite

Community medical care monitoring system for chronic patient.

Journal Article Stud Health Technol Inform · 1998 The chronic disease usually can not be cured well but controlling by the daily care activity, regular diagnosis and dosage under the physician's instructions. In this research, we propose a community medical care monitoring model for monitoring and managin ... Link to item Cite

A novel approach to the treatment of chronic allograft nephropathy.

Journal Article Transplantation · December 27, 1997 BACKGROUND: Progressive deterioration of renal function in kidney transplant recipients is the leading cause of graft failure. Both nonimmunologic and immunologic mechanisms contribute to this deterioration. METHODS: Twenty-eight cyclosporine (CsA)-treated ... Full text Link to item Cite

Use of renal allografts from donors positive for hepatitis B core antibody confers minimal risk for subsequent development of clinical hepatitis B virus disease.

Journal Article Transplantation · December 27, 1997 BACKGROUND: The risk associated with transplantation of renal allografts from hepatitis B virus core antibody-positive (HBcAb(+)), hepatitis B virus surface antigen-negative (HBsAg(-)) donors is not well defined. METHODS: Over 4 years, we performed 45 kidn ... Full text Link to item Cite

Selective bowel decontamination in hospitalized patients awaiting liver transplantation.

Journal Article Am J Surg · December 1997 BACKGROUND: Infection remains a major contributor to morbidity and mortality following orthotopic liver transplantation (OLT). Selective bowel decontamination (SBD) in hospitalized patients is one strategy for prophylaxis. METHODS: A retrospective case-con ... Full text Link to item Cite

Cytoablative therapy with combined resection and cryosurgery for limited bilobar hepatic colorectal metastases.

Journal Article Am J Surg · December 1997 BACKGROUND: Cryosurgery can be employed in patients with unresectable hepatic metastases when the tumor size and the number of metastases are limited. However, local recurrence can result from incomplete ablation. We proposed a trial of complete cytoablati ... Full text Link to item Cite

Distinctive clinical features of portopulmonary hypertension.

Journal Article Chest · October 1997 STUDY OBJECTIVE: To differentiate the cardiopulmonary profile of portopulmonary hypertension (PPHTN) from that of primary pulmonary hypertension and chronic liver disease. DESIGN: Retrospective survey. SETTING: Tertiary care center. PATIENTS: Thirty patien ... Full text Link to item Cite

Alteration of NF-kappa B p50 DNA binding kinetics by S-nitrosylation.

Journal Article Biochem Biophys Res Commun · September 29, 1997 Nitric oxide (NO) regulates a wide variety of cellular functions, in part, by formation of S-NO bonds at critical active site thiol groups within proteins, including transcription factors. Previous studies have qualitatively demonstrated that S-nitrosothio ... Full text Link to item Cite

Outcome after splenic vein thrombosis in the pancreas allograft.

Journal Article Transplantation · September 27, 1997 The outcome and management of isolated splenic vein thrombosis in the pancreas transplant is unknown. We retrospectively reviewed the records of 76 simultaneous pancreas-kidney transplantations (SPK) and 56 solitary pancreas transplantations (SPT) performe ... Full text Link to item Cite

CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages.

Journal Article Am J Physiol · September 1997 Endotoxin-mediated macrophage synthesis of nitric oxide (NO) is associated with immune effector function, intercellular communication, leukocyte adhesion, vascular integrity, and neurotransmission. However, little is known of the cellular receptor and sign ... Full text Link to item Cite

Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction.

Journal Article Surgery · August 1997 BACKGROUND: Nitric oxide (NO) is a ubiquitous multifunctional free radical produced during sepsis, shock, reperfusion injury, and allograft rejection. Many studies are presently evaluating the functional roles of NO production in these settings. However, t ... Full text Link to item Cite

Nitric oxide and acetaminophen-mediated oxidative injury: modulation of interleukin-1-induced nitric oxide synthesis in cultured rat hepatocytes.

Journal Article J Pharmacol Exp Ther · August 1997 The role of endogenous hepatocyte synthesis of nitric oxide (NO) in states of oxidative stress is largely unknown. In a model of rat hepatocytes in primary culture, NO production was induced by exposure to interleukin-1beta (IL-1beta, 50 ng/ml). Acetaminop ... Link to item Cite

The evolution of a successful liver transplant program in 1996: the clinical and administrative role of the anesthesiologist.

Journal Article Liver Transpl Surg · July 1997 The establishment of a new liver transplant program requires enormous planning and resources. Extensive negotiations must take place to ensure institutional and departmental commitments to obtain the proper equipment, personnel, and other resources. The fo ... Full text Link to item Cite

Evaluation of pancreas transplant needle biopsy: reproducibility and revision of histologic grading system.

Journal Article Transplantation · June 15, 1997 BACKGROUND: Tissue samples for the diagnosis of pancreatic allograft rejection are now obtained routinely through the application of the percutaneous needle biopsy technique. The availability of biopsy material (89% adequate for diagnosis in our setting) p ... Full text Link to item Cite

Oxidative stress increases hepatocyte iNOS gene transcription and promoter activity.

Journal Article Biochem Biophys Res Commun · May 19, 1997 Hepatocyte expression of inducible nitric oxide synthase (iNOS) is initiated by the presence of pro-inflammatory cytokines, such as interleukin-1beta (IL-1). In the presence of oxidative stress, IL-1beta mediated hepatocyte iNOS expression and NO synthesis ... Full text Link to item Cite

Safe pancreas transplantation in patients with coronary artery disease.

Journal Article Transplantation · May 15, 1997 BACKGROUND: This study was conducted to determine the risk of clinically significant posttransplant cardiac events (PCEs) in a cohort of diabetic patients referred for pancreas transplantation. METHODS: Between April 1991 and December 1995, 316 insulin-dep ... Full text Link to item Cite

Increased living donor volunteer rates with a formal recipient family education program.

Journal Article Am J Kidney Dis · May 1997 We have generally encouraged living donation among our kidney recipients. However, an examination of our clinical practice revealed inconsistencies in the depth and content of information transmitted to kidney recipient families regarding living donation. ... Full text Link to item Cite

Successful emergency transplantation of a liver allograft from a donor maintained on extracorporeal membrane oxygenation.

Journal Article Transplantation · March 27, 1997 The critical shortage of cadaveric donors for organ transplantation has led many transplant centers to accept life-saving organs from donors who would have previously been refused for transplantation. We report a novel case of the use of a liver allograft ... Full text Link to item Cite

Methemoglobinemia associated with dapsone treatment in solid organ transplant recipients: a two-case report and review.

Journal Article Liver Transpl Surg · March 1997 Dapsone, a sulfone antibiotic, has been increasingly used in solid-organ transplant recipients for the primary prevention of Pneumocystis carinii pneumonia, especially in patients with documented sulfa allergy. A known side effect of dapsone therapy, howev ... Full text Link to item Cite

Continuous intravenous infusion of epoprostenol for the treatment of portopulmonary hypertension.

Journal Article Transplantation · February 27, 1997 The association of pulmonary hypertension with portal hypertension, also called portopulmonary hypertension (PPHTN), is a known complication of chronic liver disease. Previously, the presence of PPHTN was considered to be a contraindication to orthotopic l ... Full text Link to item Cite

Prevention of autoimmune islet allograft destruction by engraftment of donor T cells.

Journal Article Transplantation · January 27, 1997 The results of clinical islet transplantation have remained poor when compared with the consistent success of pancreas transplantation. Autoimmunity has usually been discounted as a cause of islet transplant failure. Previously, we demonstrated that pancre ... Full text Link to item Cite

Simultaneous pancreas/kidney transplantation--a comparison of enteric and bladder drainage of exocrine pancreatic secretions.

Journal Article Transplantation · January 27, 1997 Simultaneous pancreas/kidney transplantation (SPK) has evolved to become a therapeutic option for patients with renal failure resulting from type 1 diabetes mellitus. However, the appropriate route for drainage of the exocrine secretions of the pancreas al ... Full text Link to item Cite

Solitary pancreas allografts. The role of percutaneous biopsy and standardized histologic grading of rejection.

Journal Article Arch Surg · January 1997 OBJECTIVE: To determine the potential impact of ultrasound-guided percutaneous pancreas allograft biopsy and standardized histologic grading on graft and patient survival in a solitary pancreas transplant program. DESIGN: Retrospective case series survey. ... Full text Link to item Cite

Portopulmonary hypertension: Evolving concepts and therapy

Journal Article Transplantation Reviews · January 1, 1997 Full text Cite

Double renal allografts successfully increase utilization of kidneys from older donors within a single organ procurement organization.

Journal Article Transplantation · December 15, 1996 BACKGROUND: In 1994, a policy of double renal allografting (DUAL) was used at two centers within our local organ procurement organization to increase utilization of kidneys from older donors that would otherwise be discarded. Both kidneys from an older don ... Full text Link to item Cite

Volume-mediated pulmonary responses in liver transplant candidates.

Journal Article Clin Transplant · December 1996 Pulmonary hypertension, defined as mean pulmonary artery pressure (mPAP) greater than or equal to 25 mmHg, is a recognized complication of hepatic dysfunction with portal hypertension and is considered a relative contraindication to liver transplantation. ... Link to item Cite

Utilization of the older donor for renal transplantation.

Journal Article Am J Surg · November 1996 BACKGROUND: The persistent shortage of ideal donor organs has resulted in increased transplantation of kidneys from older donors (age > 60 years). The overall experience with this donor subgroup indicates decreased graft survival. METHODS: The records of 4 ... Full text Link to item Cite

Equivalent success of simultaneous pancreas kidney and solitary pancreas transplantation. A prospective trial of tacrolimus immunosuppression with percutaneous biopsy.

Journal Article Ann Surg · October 1996 OBJECTIVE: This study was designed to evaluate the results of solitary pancreas transplantation in a protocol that uses the new immunosuppressant tacrolimus (FK) and liberally applies ultrasound-guided percutaneous pancreas biopsy to diagnose rejection. SU ... Full text Link to item Cite

Significance of the Banff borderline biopsy.

Journal Article Am J Kidney Dis · October 1996 In the Banff classification of kidney transplant pathology the "borderline changes" category falls short of a diagnosis of mild acute rejection, with the recommendation that no treatment is a possible clinical approach. We reviewed the clinical course of p ... Full text Link to item Cite

Interleukin-1-induced nitric oxide production modulates glutathione synthesis in cultured rat hepatocytes.

Journal Article Am J Physiol · September 1996 In cultured rat hepatocytes, we have previously demonstrated that inhibition of interleukin-1 (IL-1)-mediated nitric oxide (NO) synthesis is associated with depletion of intracellular reduced glutathione (GSH) in toxin-mediated oxidative injury. To further ... Full text Link to item Cite

Nitric oxide-associated regulation of hepatocyte glutathione synthesis is a guanylyl cyclase-independent event.

Journal Article Surgery · August 1996 BACKGROUND: In a system of rat hepatocytes in primary culture, inhibition of cytokine-mediated nitric oxide (NO) production has been shown to be protective in states of oxidative stress. In the absence of oxidative injury, inhibition of NO synthesis has be ... Full text Link to item Cite

Long-term pancreatic function: potential benefits.

Journal Article Transplant Proc · August 1996 Link to item Cite

Human syngeneic intestinal transplantation: evaluation of enterocyte viability with serum levels of intestinal fatty acid binding protein.

Journal Article Clin Transplant · June 1996 In a case of human syngeneic intestinal transplantation, the post-operative course was complicated by the Systemic Inflammatory Response System (SIRS). This syndrome was characterized by negative cultures and elevated levels of the pro-inflammatory cytokin ... Link to item Cite

The use of bilateral adult renal allografts - a method to optimize function from donor kidneys with suboptimal nephron mass.

Journal Article Transplantation · April 27, 1996 Alternatives to traditional organ donor usage has allowed expansion of the organ donor pool to help compensate for the increasing disparity between recipients and donors. The use of bilateral adult renal transplants is a novel idea to salvage older donor k ... Full text Link to item Cite

Differential localization of allograft nitric oxide synthesis: comparison of liver and heart transplantation in the rat model.

Journal Article Immunology · April 1996 Nitric oxide (NO) is a free radical with a diversity of cellular origins and potential functions. Within the realm of solid organ transplantation, NO has been the focus of much attention. Discordant reports have documented both suppression and potentiation ... Full text Link to item Cite

CO2 angiography--a technique for vascular imaging in renal allograft dysfunction.

Journal Article Transplantation · February 1996 Use of iodinated contrast for vascular imaging can be associated with nephrotoxicity and hypersensitivity reactions. Renal injury following conventional angiography is more likely to manifest in the setting of preexisting renal dysfunction. In the setting ... Full text Cite

Cellular localization and effect of nitric oxide synthesis in a rat model of orthotopic liver transplantation.

Journal Article Transplantation · January 27, 1996 Nitric oxide (NO) is a multifunctional free radical with a variety of described biochemical and physiological roles. The immunologic relationships between organ transplantation and NO synthesis are unknown. While a number of in vitro and in vivo models hav ... Full text Link to item Cite

Pancreas transplantation at the University of Maryland.

Journal Article Clin Transpl · 1996 1. The University of Maryland pancreas transplant program was initiated in July 1991. Through December 1996, 230 pancreas transplants were performed (145 SPK, 64 PAK, 21 PTA). Overall one-year patient and graft survival rates were 95.5% and 78.9%, respecti ... Link to item Cite

The utility of retroperitoneal kidney placement in simultaneous kidney pancreas transplantation.

Journal Article Clin Transplant · December 1995 Simultaneous kidney-pancreas (SPK) transplantation has become an accepted therapeutic modality for patients with Type I diabetes mellitus-mediated end-stage renal disease (ESRD). However, the intraperitoneal placement of the renal allograft may pose techni ... Link to item Cite

Orthotopic liver transplantation with selective use of venovenous bypass.

Journal Article Am J Surg · December 1995 BACKGROUND: To determine the utility of selective use of venovenous bypass (VVB), an algorithm based upon hemodynamic criteria was instituted at Stanford University Medical Center: the bypass was used if the systolic blood pressure decreased below 100 mm H ... Full text Link to item Cite

Nitric oxide: physiology and pharmacology.

Journal Article Anesth Analg · November 1995 Full text Link to item Cite

Magnetic resonance imaging-derived parameter of portal flow predicts volume-mediated pulmonary hypertension in liver transplantation candidates.

Journal Article Surgery · October 1995 BACKGROUND: Pulmonary hypertension is a source of perioperative mortality after orthotopic liver transplantation (OLT). The purpose of this study is to (1) characterize the pulmonary hemodynamic response in OLT candidates, and (2) determine whether portal ... Full text Link to item Cite

Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide.

Journal Article Surgery · August 1995 BACKGROUND: Although nitric oxide synthase (NOS) is a cytochrome P450-like hemoprotein with additional sequence homology to cytochrome P450 reductase, the role of the cytochrome P450 system in cytokine-mediated NO synthesis is unknown. METHODS: To characte ... Full text Link to item Cite

Interleukin 1-induced production of nitric oxide inhibits benzenetriol-mediated oxidative injury in rat hepatocytes.

Journal Article Gastroenterology · July 1995 BACKGROUND & AIMS: Nitric oxide modifies free radical-mediated cell processes in multiple in vivo and in vitro systems. The aim of this study was to determine the role of hepatocyte production of NO in oxidative injury. METHODS: Rat hepatocytes in primary ... Full text Link to item Cite

Assessment of living renal donors with spiral CT.

Journal Article Radiology · May 1995 PURPOSE: To determine whether spiral computed tomography (CT) can be used to evaluate potential living renal donors. MATERIALS AND METHODS: Twelve potential living renal donors underwent spiral CT and conventional arteriography. CT angiography was performe ... Full text Link to item Cite

Clinical outcome of interval cadaveric renal transplantation in cardiac allograft recipients.

Journal Article Clin Transplant · April 1995 The introduction of cyclosporine into widespread clinical use has resulted in improved patient survival following cardiac transplantation. As a result of increased numbers of cardiac transplants, the inherent nephrotoxicity of cyclosporine, and prolonged p ... Link to item Cite

Magnetic resonance imaging and hepatic hemodynamics: correlation with metabolic function in liver transplantation candidates.

Journal Article Surgery · April 1995 BACKGROUND: Preoperative assessment of orthotopic liver transplantation candidates requires definition of both the anatomy and metabolic function of the native liver. Current evaluation techniques combine computed tomographic scanning, duplex ultrasonograp ... Full text Link to item Cite

The emerging multifaceted roles of nitric oxide.

Journal Article Ann Surg · March 1995 Nitric oxide (NO) is a highly reactive free radical with a multitude of organ specific regulatory functions. Since 1985, NO has been the subject of numerous research efforts and as a result, has been found to play a major role in the cardiovascular, pulmon ... Full text Link to item Cite

Cytokine-mediated production of nitric oxide in isolated rat hepatocytes is dependent on cytochrome P-450III activity.

Journal Article FEBS Lett · February 20, 1995 To investigate the role of the cytochrome P-450 system in NO synthesis, cytochrome P-450IIIA, IIE and IA activities were specifically inhibited by cimetidine (IIIA), clotrimazole (IIIA), benzoflavone (IA) and disulfiram (IIE) in a model of cultured rat hep ... Full text Link to item Cite

A comparison of operation, endoscopic retrograde cholangiopancreatography, and percutaneous transhepatic cholangiography in biliary complications after hepatic transplantation.

Journal Article J Am Coll Surg · August 1994 BACKGROUND: Biliary complications (BC) remain a significant cause of morbidity and mortality after orthotopic liver transplantation (OLT). STUDY DESIGN: In an effort to determine the incidence of BC after OLT and the success of management options, 157 hepa ... Link to item Cite

Nitric oxide decreases oxidant-mediated hepatocyte injury.

Journal Article J Surg Res · June 1994 Nitric oxide (NO) is a readily diffusible, short-lived free radical with a multitude of organ-specific regulatory functions. Within the hepatocyte, NO production is associated with inhibition of mitochondrial electron transport enzyme activity, activation ... Full text Link to item Cite

Treatment of giant hemangiomas of the liver by enucleation.

Journal Article J Am Coll Surg · January 1994 Cavernous hemangiomas are the most common benign tumors of the liver. The results of natural history studies have demonstrated that asymptomatic hemangiomas can be observed without deleterious results. The appropriate treatment for symptomatic cavernous he ... Link to item Cite

Diagnosis and treatment of retrobulbar hemorrhage.

Journal Article J Oral Maxillofac Surg · July 1993 Complete loss of light perception in an eye is one of the most severe complications of maxillofacial surgery. Although irreversible in many cases, early recognition and prompt intervention may improve the final outcome. The purpose of this article is to re ... Full text Link to item Cite

Toxic epidermal necrolysis: report of a case.

Journal Article J Oral Maxillofac Surg · June 1992 Full text Link to item Cite

HLA histocompatibility affects cardiac transplant rejection and may provide one basis for organ allocation.

Journal Article Ann Thorac Surg · February 1990 Prospective human lymphocyte antigen (HLA) typing is not performed for heart transplantation, and the relation between HLA matching and cardiac graft rejection is unclear. Recipient and donor HLA matching were analyzed retrospectively in 51 patients underg ... Full text Link to item Cite

Lovastatin therapy for hypercholesterolemia in cardiac transplant recipients.

Journal Article Am J Cardiol · September 15, 1989 Hypercholesterolemia (type II hyperlipidemia) after cardiac transplantation is common and may play a role in the accelerated rate of coronary atherosclerosis seen following the procedure. However, conventional cholesterol-lowering drugs are either ineffect ... Full text Link to item Cite

Rhabdomyosarcoma of the parapharyngeal space in an adult patient: an immunohistochemical study.

Journal Article J Oral Maxillofac Surg · April 1989 Rhabdomyogenic malignancies occasionally challenge the diagnostic acumen of many pathologists. The diverse histologic patterns of RMS can range from the somewhat undifferentiated primitive to the bizarre, pleomorphic varieties. These neoplasms can be highl ... Full text Link to item Cite

Effect of dietary fat saturation and cholesterol on low density lipoprotein degradation by mononuclear cells of Cebus monkeys.

Journal Article Arteriosclerosis · 1989 The mechanism by which dietary unsaturated fatty acids lower low density lipoprotein (LDL) cholesterol is unknown. Unsaturated fatty acids incorporated into the cell membrane can increase membrane fluidity and, as a result, dramatically alter membrane-depe ... Full text Link to item Cite

Ground-state photoneutron reactions in sup18O.

Journal Article Phys Rev C Nucl Phys · October 1987 Full text Link to item Cite

Proliferative periostitis (Garré's osteomyelitis).

Journal Article Oral Surg Oral Med Oral Pathol · February 1987 Full text Link to item Cite

Ground-state photoneutron reactions in 14C.

Journal Article Phys Rev C Nucl Phys · February 1985 Full text Link to item Cite

Maxillo-facial surgical approach: an introduction and review of mandibular advancement.

Journal Article Bull Eur Physiopathol Respir · 1983 Patients afflicted with obstructive hypersomnia sleep apnea (HSA) have been treated traditionally with permanent tracheostomy. More recently, an association between HSA and mandibular retrognathism has been noted. Several centers have reported rapid revers ... Link to item Cite

Huntington disease and Tourette syndrome. I. Electron spin resonance of bed ghosts.

Journal Article Am J Hum Genet · March 1981 Abnormalities in the electron spin resonance (ESR) of nitroxide-labeled red blood cell membranes have been reported in Huntington disease (HD). Because of the importance of verifying a general membrane defect in this disease, we have examined 13 unmedicate ... Link to item Cite

The effect of mandibular osteotomy in three patients with hypersomnia sleep apnea.

Journal Article Oral Surg Oral Med Oral Pathol · November 1979 Hypersomnia sleep apnea (HSA) is characterized by apneic episodes during sleep and daytime hypersomnolence. Patients afflicted as a result of upper airway obstruction have been treated traditionally with permanent tracheostomy. Three patients with HSA and ... Full text Link to item Cite