Scholars@Duke
Laura Pope Hale

Laura Pope Hale

Professor of Pathology
Pathology
laura.hale@duke.edu
Duke Box 3712, Durham, NC 27710
214C Davison Bldg, Durham, NC 27710
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Selected Publications

Age-related epithelial defects limit thymic function and regeneration.

Journal Article Nat Immunol · September 2024 The thymus is essential for establishing adaptive immunity yet undergoes age-related involution that leads to compromised immune responsiveness. The thymus is also extremely sensitive to acute insult and although capable of regeneration, this capacity decl ... Full text Link to item Cite

Comprehensive Flow Cytometric, Immunohistologic, and Molecular Assessment of Thymus Function in Rhesus Macaques.

Journal Article Immunohorizons · July 1, 2024 The critical importance of the thymus for generating new naive T cells that protect against novel infections and are tolerant to self-antigens has led to a recent revival of interest in monitoring thymic function in species other than humans and mice. Nonh ... Full text Link to item Cite

Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres.

Journal Article Nat Biomed Eng · May 2024 Inflammatory bowel disease lacks a long-lasting and broadly effective therapy. Here, by taking advantage of the anti-infection and anti-inflammatory properties of natural antibodies against the small-molecule epitope phosphorylcholine (PC), we show in mult ... Full text Link to item Cite

CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance.

Journal Article Elife · June 2, 2023 Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their T-cell receptors (TCRs) for autoreactivi ... Full text Link to item Cite

Irgm1 regulates metabolism and function in T cell subsets.

Journal Article Sci Rep · January 17, 2022 Immunity Related GTPases (IRG) are a family of proteins produced during infection that regulate membrane remodeling events in cells, particularly autophagy and mitophagy. The human IRGM gene has been strongly associated with Crohn's disease and other infla ... Full text Link to item Cite

T cell-depleted cultured pediatric thymus tissue as a model for some aspects of human age-related thymus involution.

Journal Article Geroscience · June 2021 Human age-related thymus involution is characterized by loss of developing thymocytes and the thymic epithelial network that supports them, with replacement by adipose tissue. The mechanisms that drive these changes are difficult to study in vivo due to co ... Full text Open Access Link to item Cite

Data and Code from: T Cell-Depleted Cultured Pediatric Thymus Tissue as a Model for Some Aspects of Human Age-Related Thymus Involution

Dataset · January 4, 2021 Human age-related thymus involution is characterized by loss of developing thymocytes and the thymic epithelial network that supports them, with replacement by adipose tissue. The mechanisms that drive these changes are difficult to study in vivo due to co ... Full text Cite

Age-Related Changes in Thymic Central Tolerance.

Journal Article Front Immunol · 2021 Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the thymus microenvironment provide essential signals to self-reactive thymocytes that induce either negative selection or generation of regulatory T cells (Treg), both of ... Full text Link to item Cite

Targeting T-cell oxidative metabolism to improve influenza survival in a mouse model of obesity.

Journal Article Int J Obes (Lond) · December 2020 BACKGROUND: Obesity is associated with impaired primary and secondary immune responses to influenza infection, with T cells playing a critical role. T-cell function is highly influenced by the cellular metabolic state; however, it remains unknown how alter ... Full text Link to item Cite

A mosaic analysis system with Cre or Tomato expression in the mouse.

Journal Article Proc Natl Acad Sci U S A · November 10, 2020 Somatic mutations are major genetic contributors to cancers and many other age-related diseases. Many disease-causing somatic mutations can initiate clonal growth prior to the appearance of any disease symptoms, yet experimental models that can be used to ... Full text Link to item Cite

Histopathologic assessment of cultured human thymus.

Journal Article PLoS One · 2020 The maintenance and propagation of complex mixtures of cells in vitro in the form of native organs or engineered organoids has contributed to understanding mechanisms of cell and organ development and function which can be translated into therapeutic benef ... Full text Open Access Link to item Cite

Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis.

Journal Article PLoS One · 2020 Patients with inflammatory bowel disease (IBD) have an increased risk of colorectal cancer, particularly in ulcerative colitis (UC) when the majority of colon epithelial cells may be exposed to inflammation-associated mutagenesis. In addition to mutagenesi ... Full text Link to item Cite

Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques.

Journal Article PLoS One · 2019 While exposure to radiation can be lifesaving in certain settings, it can also potentially result in long-lasting adverse effects, particularly to hematopoietic and immune cells. This study investigated hematopoietic recovery and immune function in rhesus ... Full text Link to item Cite

Microbial nitrogen limitation in the mammalian large intestine.

Journal Article Nat Microbiol · December 2018 Resource limitation is a fundamental factor governing the composition and function of ecological communities. However, the role of resource supply in structuring the intestinal microbiome has not been established and represents a challenge for mammals that ... Full text Link to item Cite

Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort.

Conference Vaccine · October 29, 2018 The objective of this study was to evaluate effects of whole body radiation exposure early in life on influenza vaccination immune responses much later in life. A total of 292 volunteers recruited from the cohort members of ongoing Adult Health Study (AHS) ... Full text Link to item Cite

Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function.

Journal Article Radiat Res · May 2017 The thymus is essential for proper development and maintenance of a T-cell repertoire that can respond to newly encountered antigens, but its function can be adversely affected by internal factors such as pregnancy and normal aging or by external stimuli s ... Full text Link to item Cite

Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88.

Journal Article Cell Rep · October 25, 2016 Normal dynamics between microbiota and dendritic cells (DCs) support modest numbers of T cells, yet these do not cause inflammation. The DCs that induce inflammatory T cells and the signals that drive this process remain unclear. Here, we demonstrate that ... Full text Open Access Link to item Cite

Age-related epithelial defects limit thymic function and regeneration.

Journal Article Nat Immunol · September 2024 The thymus is essential for establishing adaptive immunity yet undergoes age-related involution that leads to compromised immune responsiveness. The thymus is also extremely sensitive to acute insult and although capable of regeneration, this capacity decl ... Full text Link to item Cite

Comprehensive Flow Cytometric, Immunohistologic, and Molecular Assessment of Thymus Function in Rhesus Macaques.

Journal Article Immunohorizons · July 1, 2024 The critical importance of the thymus for generating new naive T cells that protect against novel infections and are tolerant to self-antigens has led to a recent revival of interest in monitoring thymic function in species other than humans and mice. Nonh ... Full text Link to item Cite

Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres.

Journal Article Nat Biomed Eng · May 2024 Inflammatory bowel disease lacks a long-lasting and broadly effective therapy. Here, by taking advantage of the anti-infection and anti-inflammatory properties of natural antibodies against the small-molecule epitope phosphorylcholine (PC), we show in mult ... Full text Link to item Cite

CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance.

Journal Article Elife · June 2, 2023 Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their T-cell receptors (TCRs) for autoreactivi ... Full text Link to item Cite

Irgm1 regulates metabolism and function in T cell subsets.

Journal Article Sci Rep · January 17, 2022 Immunity Related GTPases (IRG) are a family of proteins produced during infection that regulate membrane remodeling events in cells, particularly autophagy and mitophagy. The human IRGM gene has been strongly associated with Crohn's disease and other infla ... Full text Link to item Cite

T cell-depleted cultured pediatric thymus tissue as a model for some aspects of human age-related thymus involution.

Journal Article Geroscience · June 2021 Human age-related thymus involution is characterized by loss of developing thymocytes and the thymic epithelial network that supports them, with replacement by adipose tissue. The mechanisms that drive these changes are difficult to study in vivo due to co ... Full text Open Access Link to item Cite

Data and Code from: T Cell-Depleted Cultured Pediatric Thymus Tissue as a Model for Some Aspects of Human Age-Related Thymus Involution

Dataset · January 4, 2021 Human age-related thymus involution is characterized by loss of developing thymocytes and the thymic epithelial network that supports them, with replacement by adipose tissue. The mechanisms that drive these changes are difficult to study in vivo due to co ... Full text Cite

Age-Related Changes in Thymic Central Tolerance.

Journal Article Front Immunol · 2021 Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the thymus microenvironment provide essential signals to self-reactive thymocytes that induce either negative selection or generation of regulatory T cells (Treg), both of ... Full text Link to item Cite

Targeting T-cell oxidative metabolism to improve influenza survival in a mouse model of obesity.

Journal Article Int J Obes (Lond) · December 2020 BACKGROUND: Obesity is associated with impaired primary and secondary immune responses to influenza infection, with T cells playing a critical role. T-cell function is highly influenced by the cellular metabolic state; however, it remains unknown how alter ... Full text Link to item Cite

A mosaic analysis system with Cre or Tomato expression in the mouse.

Journal Article Proc Natl Acad Sci U S A · November 10, 2020 Somatic mutations are major genetic contributors to cancers and many other age-related diseases. Many disease-causing somatic mutations can initiate clonal growth prior to the appearance of any disease symptoms, yet experimental models that can be used to ... Full text Link to item Cite

Histopathologic assessment of cultured human thymus.

Journal Article PLoS One · 2020 The maintenance and propagation of complex mixtures of cells in vitro in the form of native organs or engineered organoids has contributed to understanding mechanisms of cell and organ development and function which can be translated into therapeutic benef ... Full text Open Access Link to item Cite

Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis.

Journal Article PLoS One · 2020 Patients with inflammatory bowel disease (IBD) have an increased risk of colorectal cancer, particularly in ulcerative colitis (UC) when the majority of colon epithelial cells may be exposed to inflammation-associated mutagenesis. In addition to mutagenesi ... Full text Link to item Cite

Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques.

Journal Article PLoS One · 2019 While exposure to radiation can be lifesaving in certain settings, it can also potentially result in long-lasting adverse effects, particularly to hematopoietic and immune cells. This study investigated hematopoietic recovery and immune function in rhesus ... Full text Link to item Cite

Microbial nitrogen limitation in the mammalian large intestine.

Journal Article Nat Microbiol · December 2018 Resource limitation is a fundamental factor governing the composition and function of ecological communities. However, the role of resource supply in structuring the intestinal microbiome has not been established and represents a challenge for mammals that ... Full text Link to item Cite

Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort.

Conference Vaccine · October 29, 2018 The objective of this study was to evaluate effects of whole body radiation exposure early in life on influenza vaccination immune responses much later in life. A total of 292 volunteers recruited from the cohort members of ongoing Adult Health Study (AHS) ... Full text Link to item Cite

Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function.

Journal Article Radiat Res · May 2017 The thymus is essential for proper development and maintenance of a T-cell repertoire that can respond to newly encountered antigens, but its function can be adversely affected by internal factors such as pregnancy and normal aging or by external stimuli s ... Full text Link to item Cite

Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88.

Journal Article Cell Rep · October 25, 2016 Normal dynamics between microbiota and dendritic cells (DCs) support modest numbers of T cells, yet these do not cause inflammation. The DCs that induce inflammatory T cells and the signals that drive this process remain unclear. Here, we demonstrate that ... Full text Open Access Link to item Cite

Optimization of Single- and Dual-Color Immunofluorescence Protocols for Formalin-Fixed, Paraffin-Embedded Archival Tissues.

Journal Article J Histochem Cytochem · February 2016 Performance of immunofluorescence staining on archival formalin-fixed paraffin-embedded human tissues is generally not considered to be feasible, primarily due to problems with tissue quality and autofluorescence. We report the development and application ... Full text Link to item Cite

Reproduction and Growth in a Murine Model of Early Life-Onset Inflammatory Bowel Disease.

Journal Article PLoS One · 2016 Studies in transgenic murine models have provided insight into the complexity underlying inflammatory bowel disease (IBD), a disease hypothesized to result from an injurious immune response against intestinal microbiota. We recently developed a mouse model ... Full text Open Access Link to item Cite

Immunogenicity and protection conferred by a recombinant Mycobacterium marinum vaccine against Buruli ulcer

Journal Article Trials in Vaccinology · January 1, 2016 Mycobacterium ulcerans (MU) infection causes the disfiguring necrotic skin disease, Buruli ulcer (BU). While vaccination with Mycobacterium bovis BCG provides nominal antigenic cross-reactivity for induction of immunity against experimental MU infection, a ... Full text Cite

Recombinant BCG Expressing Mycobacterium ulcerans Ag85A Imparts Enhanced Protection against Experimental Buruli ulcer.

Journal Article PLoS Negl Trop Dis · September 2015 Buruli ulcer, an emerging tropical disease caused by Mycobacterium ulcerans (MU), is characterized by disfiguring skin necrosis and high morbidity. Relatively little is understood about the mode of transmission, pathogenesis, or host immune responses to MU ... Full text Link to item Cite

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.

Journal Article J Clin Invest · January 2015 Activation of CD4+ T cells results in rapid proliferation and differentiation into effector and regulatory subsets. CD4+ effector T cell (Teff) (Th1 and Th17) and Treg subsets are metabolically distinct, yet the specific metabolic differences that modify T ... Full text Open Access Link to item Cite

The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.

Journal Article Cell Metab · July 1, 2014 CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While each subset prefers distinct glycolytic or oxidative metabolic programs in vitro, requirements and mech ... Full text Link to item Cite

Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest.

Journal Article Crit Care Med · September 2013 OBJECTIVE: Cardiac surgery, especially when employing cardiopulmonary bypass and deep hypothermic circulatory arrest, is associated with systemic inflammatory responses that significantly affect morbidity and mortality. Intestinal perfusion abnormalities h ... Full text Link to item Cite

Effect of pain management on immunization efficacy in mice.

Journal Article J Am Assoc Lab Anim Sci · July 2012 Immunization with complete Freund adjuvant (CFA) or incomplete Freund adjuvant (IFA) is commonly viewed as painful, yet rodents may not receive analgesics due to concerns that these drugs affect the desired immune responses. Here we tested the hypothesis t ... Link to item Cite

Iron supplementation decreases severity of allergic inflammation in murine lung.

Journal Article PLoS One · 2012 The incidence and severity of allergic asthma have increased over the last century, particularly in the United States and other developed countries. This time frame was characterized by marked environmental changes, including enhanced hygiene, decreased pa ... Full text Link to item Cite

A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features.

Journal Article PLoS One · 2012 Mutations that increase susceptibility to inflammatory bowel disease (IBD) have been identified in a number of genes in both humans and mice, but the factors that govern how these mutations contribute to IBD pathogenesis and result in phenotypic presentati ... Full text Link to item Cite

Effect of Pain Management on Immunization Efficacy in Mice

Journal Article JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE · September 1, 2011 Link to item Cite

Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam.

Journal Article PLoS One · 2011 Many commonly used non-steroidal anti-inflammatory drugs (NSAIDs) also cause gastrointestinal toxicity, including the development of life-threatening peptic ulcers. We report that mast cell-deficient mice have an extremely high incidence of severe peptic u ... Full text Link to item Cite

Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis.

Journal Article Inflamm Bowel Dis · December 2010 BACKGROUND: Bromelain, a mixture of proteolytic enzymes typically derived from pineapple stem, decreases production of proinflammatory cytokines and leukocyte homing to sites of inflammation. We previously showed that short-term oral treatment with bromela ... Full text Link to item Cite

Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids.

Journal Article Metabolism · September 2010 Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man. Serum levels of ZAG correlated with serum leve ... Full text Link to item Cite

Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice.

Journal Article PLoS One · August 17, 2010 BACKGROUND: Inflammatory bowel disease (IBD) is hypothesized to result from stimulation of immune responses against resident intestinal bacteria within a genetically susceptible host. Mast cells may play a critical role in IBD pathogenesis, since they are ... Full text Open Access Link to item Cite

Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency.

Journal Article Exp Dermatol · June 2010 Hair loss (alopecia) can result from a variety of metabolic, endocrine, immunologic, and environmental causes. This investigation was undertaken to determine the mechanisms underlying the sporadic development of alopecia in litters from C57BL/6 interleukin ... Full text Link to item Cite

The mast cell activator compound 48/80 is safe and effective when used as an adjuvant for intradermal immunization with Bacillus anthracis protective antigen.

Journal Article Vaccine · June 2, 2009 We evaluated the safety and efficacy of the mast cell activator compound 48/80 (C48/80) when used as an adjuvant delivered intradermally (ID) with recombinant anthrax protective antigen (rPA) in comparison with two well-known adjuvants. Mice were vaccinate ... Full text Link to item Cite

Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma.

Journal Article Proc Natl Acad Sci U S A · May 26, 2009 Kaposi's sarcoma (KS) is the major AIDS-associated malignancy. It is characterized by the proliferation of spindle cells, inflammatory infiltrate, and aberrant angiogenesis caused by Kaposi's sarcoma herpesvirus (KSHV) infection. Small GTPase Rac1, an infl ... Full text Link to item Cite

Effects of Helicobacter infection on research: the case for eradication of Helicobacter from rodent research colonies.

Journal Article Comp Med · February 2009 Featured Publication Infection of mouse colonies with Helicobacter spp. has become an increasing concern for the research community. Although Helicobacter infection may cause clinical disease, investigators may be unaware that their laboratory mice are infected because the pat ... Link to item Cite

Characterization of cultured thymus tissue used for transplantation with emphasis on promiscuous expression of thyroid tissue-specific genes.

Journal Article Immunol Res · 2009 Autoimmune thyroid disease occurs in some complete DiGeorge anomaly patients after thymus transplantation. This study was designed to assess the effect of culture of thymus tissue on the expression of genes involved in the development of autoimmunity. The ... Full text Link to item Cite

Thymus transplantation

Journal Article · December 1, 2008 Thymus transplantation was first attempted in the 1960s and 1970s using fetal thymus tissue [1, 2]. The results overall were disappointing [3-6]. In part the poor outcomes related to the lack of reagents needed to characterize and identify the patients int ... Full text Cite

Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice.

Journal Article Comp Med · December 2008 Featured Publication Infection with Helicobacter species is endemic in many animal facilities and may alter the penetrance of inflammatory bowel disease (IBD) phenotypes. However, little is known about the relative pathogenicity of H. typhlonius, H. rodentium, and combined inf ... Link to item Cite

Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad.

Journal Article Am J Physiol Gastrointest Liver Physiol · December 2008 Featured Publication The complex interaction of genetic, microbial, and environmental factors may result in continuous activation of the mucosal immune system leading to inflammatory bowel disease (IBD). Most present treatments for IBD involve altering or suppressing the aberr ... Full text Link to item Cite

Helicobacter infection decreases reproductive performance of IL10-deficient mice.

Journal Article Comp Med · October 2008 Featured Publication Infections with a variety of Helicobacter species have been documented in rodent research facilities, with variable effects on rodent health. Helicobacter typhlonius has been reported to cause enteric disease in immunodeficient and IL10(-/-) mice, whereas ... Link to item Cite

Bromelain treatment decreases neutrophil migration to sites of inflammation.

Journal Article Clin Immunol · July 2008 Featured Publication Bromelain, a mixture of proteases derived from pineapple stem, has been reported to have therapeutic benefits in a variety of inflammatory diseases, including murine inflammatory bowel disease. The purpose of this work was to understand potential mechanism ... Full text Link to item Cite

Use of allograft biopsies to assess thymopoiesis after thymus transplantation.

Journal Article J Immunol · May 1, 2008 Thymus allograft biopsies were performed in athymic infants with complete DiGeorge anomaly after thymus transplantation to assess whether the thymus allograft tissue was able to support thymopoiesis. Forty-four consecutive infants were treated with postnat ... Full text Link to item Cite

Treatment of experimental colitis in mice with LMP-420, an inhibitor of TNF transcription.

Journal Article J Inflamm (Lond) · March 10, 2008 Featured Publication BACKGROUND: LMP-420 is a boronic acid-containing purine nucleoside analogue that transcriptionally inhibits TNF production but is non-cytotoxic to TNF-producing cells. METHODS: This study investigated the efficacy of LMP-420 as an anti-inflammatory agent i ... Full text Link to item Cite

Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro.

Journal Article Clin Immunol · March 2008 Featured Publication Oral bromelain has been anecdotally reported to decrease inflammation in ulcerative colitis (UC). Proteolytically active bromelain is known to decrease expression of mRNAs encoding pro-inflammatory cytokines by human leukocytes in vitro. To assess the effe ... Full text Link to item Cite

Neonatal co-infection with helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-) mice.

Journal Article Helicobacter · December 2007 Featured Publication BACKGROUND: Inflammatory bowel disease (IBD) is hypothesized to represent an aberrant immune response against enteric bacteria that occurs in a genetically susceptible host. Humans and mice with IBD are at markedly increased risk for colonic neoplasia. How ... Full text Link to item Cite

Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants.

Journal Article Blood · May 15, 2007 The purpose of this study was to characterize a large group of infants with complete DiGeorge anomaly and to evaluate the ability of thymus transplantation to reconstitute immune function in these infants. DiGeorge anomaly is characterized by varying defec ... Full text Link to item Cite

Spatial organisation of microbiota in quiescent adenoiditis and tonsillitis.

Journal Article J Clin Pathol · March 2007 BACKGROUND: The reasons for recurrent adenotonsillitis are poorly understood. METHODS: The in situ composition of microbiota of nasal (5 children, 25 adults) and of hypertrophied adenoid and tonsillar tissue (50 children, 20 adults) was investigated using ... Full text Link to item Cite

Oral immunogenicity of the plant proteinase bromelain.

Journal Article Int Immunopharmacol · December 20, 2006 Featured Publication Bromelain is a natural mixture of proteolytic enzymes derived from pineapple stem that has been shown to have anti-inflammatory activity when administered orally. Although most proteins given orally without adjuvant (e.g., food) result in tolerance, we pre ... Full text Link to item Cite

Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations.

Journal Article Mamm Genome · February 2006 Cerebral cavernous malformations are vascular defects of the central nervous system consisting of clusters of dilated vessels that are subject to frequent hemorrhaging. The genes mutated in three forms of autosomal dominant cerebral cavernous malformations ... Full text Link to item Cite

Bacteria associated with bacterial vaginosis.

Journal Article N Engl J Med · January 12, 2006 Full text Link to item Cite

Piroxicam treatment of IL-10-deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteria.

Journal Article Inflamm Bowel Dis · December 2005 Featured Publication Treatment with the nonsteroidal anti-inflammatory drugs piroxicam or sulindac was recently shown to accelerate the development of colitis in interleukin (IL)-10-deficient (IL-10) mice. Although NSAIDs have been hypothesized to decrease the barrier function ... Full text Link to item Cite

Adherent biofilms in bacterial vaginosis.

Journal Article Obstet Gynecol · November 2005 OBJECTIVE: Bacterial vaginosis is a common infectious disorder. Although known since ancient times, little progress has occurred in identifying causal factors. Our aims were to study the bacterial community structure and the spatial organization of microbi ... Full text Link to item Cite

Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus function.

Journal Article J Clin Immunol · September 2005 A key determinant of T cell dynamics in HIV-1 infection is the status of thymic function. To date, most studies of the impact of HIV-1 on the thymus during early HIV-1 infection have been done in samples collected in the interval of 3-12 months after infec ... Full text Link to item Cite

Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.

Journal Article Clin Immunol · August 2005 Featured Publication Bromelain is a mixture of proteinases derived from pineapple stem that is marketed in health food stores as a "digestive aid". Orally administered bromelain was anecdotally reported to induce clinical and endoscopic remission of ulcerative colitis in two p ... Full text Link to item Cite

Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease.

Journal Article J Clin Microbiol · July 2005 Featured Publication The composition and spatial organization of the mucosal flora in biopsy specimens from patients with inflammatory bowel disease (IBD; either Crohn's disease or ulcerative colitis), self-limiting colitis, irritable-bowel syndrome (IBS), and healthy controls ... Full text Link to item Cite

Proteinase activity and stability of natural bromelain preparations.

Journal Article Int Immunopharmacol · April 2005 Bromelain is a complex mixture of proteinases typically derived from pineapple stem. Similar proteinases are also present in pineapple fruit. Beneficial therapeutic effects of bromelain have been suggested or proven in several human inflammatory diseases a ... Full text Link to item Cite

Bacterial biofilm within diseased pancreatic and biliary tracts.

Journal Article Gut · March 2005 BACKGROUND: Bacterial community structures in human pancreatic and biliary tracts were evaluated. METHODS: Gall bladder stones from 153 patients, 20 gall bladder walls, six common duct stones, 52 biliary stents, 21 duodenal biopsies, nine pancreatic duct b ... Full text Link to item Cite

Spatial organization of bacterial flora in normal and inflamed intestine: a fluorescence in situ hybridization study in mice.

Journal Article World J Gastroenterol · February 28, 2005 Featured Publication AIM: To study the role of intestinal flora in inflammatory bowel disease (IBD). METHODS: The spatial organization of intestinal flora was investigated in normal mice and in two models of murine colitis using fluorescence in situ hybridization. RESULTS: The ... Full text Link to item Cite

Adherent biofilms in bacterial vaginosis

Journal Article Obstetrics and Gynecology · 2005 OBJECTIVE: Bacterial vaginosis is a common infectious disorder. Although known since ancient times, little progress has occurred in identifying causal factors. Our aims were to study the bacterial community structure and the spatial organization of microbi ... Cite

Thymic transplantation for complete DiGeorge syndrome: medical and surgical considerations.

Journal Article J Pediatr Surg · November 2004 BACKGROUND/PURPOSE: Complete DiGeorge syndrome results in the absence of functional T cells. Our program supports the transplantation of allogeneic thymic tissue in infants with DiGeorge syndrome to reconstitute immune function. This study reviews the mult ... Full text Link to item Cite

Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome.

Journal Article Blood · October 15, 2004 Complete DiGeorge syndrome is a fatal congenital disorder characterized by athymia, hypoparathyroidism, and heart defects. Less than half of patients are 22q11 hemizygous. The goal of this study was to assess if immune suppression followed by postnatal thy ... Full text Link to item Cite

Pathology of parainfluenza virus infection in patients with congenital immunodeficiency syndromes.

Journal Article Hum Pathol · May 2004 Infection with parainfluenza virus typically produces a mild, self-limited upper respiratory infection. However, parainfluenza infections have become increasingly recognized as a source of severe morbidity and mortality in immunocompromised patients. In th ... Full text Link to item Cite

Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases.

Journal Article J Allergy Clin Immunol · April 2004 BACKGROUND: Five patients with DiGeorge syndrome presented with infections, skin rashes, and lymphadenopathy after the newborn period. T-cell counts and function varied greatly in each patient. Initial laboratory testing did not suggest athymia in these pa ... Full text Link to item Cite

Bromelain treatment of inflammatory bowel disease

Conference GASTROENTEROLOGY · April 1, 2004 Link to item Cite

Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice.

Journal Article Int Immunopharmacol · February 2004 Bromelain is a mixture of proteinases derived from pineapple stem that is marketed by health food stores as a "digestive aid". A number of studies suggest that bromelain may also have anti-inflammatory activity in vivo, including an anecdotal report descri ... Full text Link to item Cite

Histologic and molecular assessment of human thymus.

Journal Article Ann Diagn Pathol · February 2004 Most work describing the histopathology of normal human thymus has focused on pediatric thymus because of tissue availability and high thymopoietic activity. However, pathologic examination of the thymus can provide information about immune status that is ... Full text Link to item Cite

Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus.

Journal Article J Immunol · January 1, 2004 The presence of characteristic epithelial swirls called Hassall bodies within the human thymic medulla has been used as an indicator of ongoing or recent thymopoiesis. We present a case where Hassall bodies were present in the absence of current or past th ... Full text Link to item Cite

Abnormal development of thymic dendritic and epithelial cells in human X-linked severe combined immunodeficiency.

Journal Article Clin Immunol · January 2004 The X-linked form of severe combined immunodeficiency (X-SCID) is caused by mutations in the common cytokine receptor gamma chain and results in lack of T and NK cells and defective B cells. Without immune reconstitution, X-SCID patients typically die from ... Full text Link to item Cite

Fatal disseminated adenovirus infections in immunocompromised patients.

Conference Am J Clin Pathol · October 2003 Adenovirus has emerged as an important pathogen in immunocompromised patients, in whom disseminated disease occurs frequently and is associated with a high mortality rate. In a retrospective review of 1,847 consecutive autopsies, we identified 84 cases whe ... Full text Link to item Cite

Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients.

Journal Article Blood · August 1, 2003 Complete DiGeorge syndrome is a fatal condition in which infants have no detectable thymus function. The optimal treatment for the immune deficiency of complete DiGeorge syndrome has not been determined. Safety and efficacy of thymus transplantation were e ... Full text Link to item Cite

A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2.

Journal Article Hum Mol Genet · March 1, 2003 Hereditary hemorrhagic telangiectasia (HHT) is an autosomal-dominant disorder characterized by the age-dependent development of focal arteriovenous malformations and telangiectases. HHT type 2 is caused by loss of function mutations in activin receptor-lik ... Full text Link to item Cite

Idiopathic hyperammonemia following an unrelated cord blood transplant for mucopolysaccharidosis I.

Journal Article Pediatr Dev Pathol · 2003 Bone marrow transplantation (BMT) has been shown to reverse or stabilize some manifestations of mucopolysaccharidosis I (Hurler syndrome). Idiopathic hyperammonemia (IHA) is a rare complication of solid organ and BMT that is characterized by elevated serum ... Full text Link to item Cite

Thymic model for examining BRCA2 expression and function.

Journal Article Mol Carcinog · November 2002 Mutations in the human BRCA2 breast cancer susceptibility gene are associated with increased risks of breast, ovarian, and other cancers. BRCA2 has been hypothesized to function in processes of DNA damage/breakage repair, cell proliferation, and apoptosis. ... Full text Link to item Cite

A murine model for hereditary hemorrhagic telangiectasia type 2.

Conference AMERICAN JOURNAL OF HUMAN GENETICS · October 1, 2002 Link to item Cite

2C9 anti-BRCA2

Journal Article HYBRIDOMA AND HYBRIDOMICS · October 1, 2002 Link to item Cite

Zinc alpha-2-glycoprotein regulates melanin production by normal and malignant melanocytes.

Journal Article J Invest Dermatol · August 2002 Zinc alpha-2-glycoprotein is secreted by a variety of normal and malignant epithelial cells and overexpression by tumors has been implicated in cancer cachexia. To investigate biologic properties of zinc alpha-2-glycoprotein further, stable transfectants o ... Full text Link to item Cite

BRCA2 monoclonal antibodies react with differentiating epithelium.

Journal Article Hybrid Hybridomics · August 2002 The BRCA2 gene has previously been suggested to play a role in proliferation and DNA repair. Germline mutations in the BRCA2 gene predispose individuals to early onset, hereditary breast cancer. To better understand the expression pattern and function of t ... Full text Link to item Cite

Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation.

Journal Article Clin Immunol · August 2002 Featured Publication Bromelain is a natural proteinase preparation derived from pineapple stem that is marketed for oral use as a digestive aid and as an antiinflammatory agent. Bromelain treatment in vitro has been previously shown to selectively remove certain cell surface m ... Full text Link to item Cite

Thymic transplantation in complete DiGeorge syndrome.

Journal Article CLINICAL IMMUNOLOGY · June 1, 2002 Link to item Cite

An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus.

Journal Article J Immunol · April 15, 2002 The importance of E2A transcription factors in T cell development has been demonstrated in studies of E2A-deficient mice, which display abnormal T cell development and a high frequency of T cell lymphomas. Because E2A expression is not restricted to the T ... Full text Link to item Cite

Hypoxia in the thymus: role of oxygen tension in thymocyte survival.

Journal Article Am J Physiol Heart Circ Physiol · April 2002 Our previous studies using oxygen microelectrodes showed that the thymus is grossly hypoxic under normal physiological conditions. We now have investigated how oxygen tension affects the thymus at the cellular and molecular level. Adducts of the hypoxia ma ... Full text Link to item Cite

Fatal disseminated adenovirus infection in immunocompromised patients

Journal Article LABORATORY INVESTIGATION · January 1, 2002 Link to item Cite

Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy.

Journal Article AIDS Res Hum Retroviruses · November 20, 2001 The thymus of HIV-seropositive patients can enlarge as CD4+ T cell counts increase on highly active anti-retroviral therapy (HAART). This may indicate development of new T cells or represent mature peripheral T cells recirculating to the thymus. To define ... Full text Link to item Cite

B cells in epithelial and perivascular compartments of human adult thymus.

Journal Article Hum Pathol · September 2001 The thymus is the site of T-cell differentiation. However, the relatively recent observation that B cells are also present in the human thymus has prompted studies to determine the origin and function of these B cells. Our studies show that phenotypically ... Full text Link to item Cite

Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer.

Journal Article Clin Cancer Res · April 2001 Zinc alpha-2-glycoprotein (ZAG) is a M(r) 41,000 glycoprotein secreted by a variety of normal epithelia. ZAG was recently shown to stimulate lipolysis in adipocytes, leading to the development of cachexia in animals with ZAG-producing tumors. To understand ... Link to item Cite

Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis.

Journal Article J Immunol · February 15, 2001 The human thymus is required for establishment of the T cell pool in fetal life, but postnatal thymectomy does not lead to immunodeficiency in humans. Because thymectomy in humans is performed for treatment of myasthenia gravis (MG), we have studied patien ... Full text Link to item Cite

Age-related thymic atrophy in the guinea pig.

Journal Article Dev Comp Immunol · 2001 We have characterized age-related thymic atrophy in the guinea pig, including identification of antibodies that allow immunohistochemical assessment of thymopoiesis. Age-related thymic atrophy in guinea pigs more closely resembles what occurs in humans his ... Full text Link to item Cite

Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors.

Journal Article Proc Natl Acad Sci U S A · June 20, 2000 The epidermal growth factor receptor (EGFR) is often amplified and rearranged structurally in tumors of the brain, breast, lung, and ovary. The most common mutation, EGFRvIII, is characterized by an in-frame deletion of 801 base pairs, resulting in the gen ... Full text Link to item Cite

Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection.

Journal Article AIDS Res Hum Retroviruses · March 20, 2000 The purpose of this study was to determine whether thymic transplantation in addition to highly active antiretroviral therapy (HAART) will restore T cell function in HIV infection. Eight treatment-naive HIV-infected patients with CD4+ T cell counts of 200- ... Full text Link to item Cite

Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy.

Journal Article J Immunol · February 15, 2000 The roles that thymus cytokines might play in regulating thymic atrophy are not known. Reversing thymic atrophy is important for immune reconstitution in adults. We have studied cytokine mRNA steady-state levels in 45 normal human (aged 3 days to 78 years) ... Full text Link to item Cite

The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection.

Journal Article Annu Rev Immunol · 2000 The human thymus is a complex chimeric organ comprised of central (thymic epithelial space) and peripheral (perivascular space) components that functions well into adult life to produce naive T lymphocytes. Recent advances in identifying thymic emigrants a ... Full text Link to item Cite

The human thymus during aging.

Journal Article Immunol Res · 2000 The human thymus is required for establishment of a normal T cell repertoire in fetal development, as children born without a thymus (DiGeorge Syndrome) lack thymus-derived (T) and T cell immunity. While the function of the thymus in children for productio ... Full text Link to item Cite

Transplantation of thymus tissue in complete DiGeorge syndrome.

Journal Article N Engl J Med · October 14, 1999 BACKGROUND: The DiGeorge syndrome is a congenital disorder that affects the heart, parathyroid glands, and thymus. In complete DiGeorge syndrome, patients have severely reduced T-cell function. METHODS: We treated five infants (age, one to four months) wit ... Full text Link to item Cite

Analysis of the human thymic perivascular space during aging.

Journal Article J Clin Invest · October 1999 The perivascular space (PVS) of human thymus increases in volume during aging as thymopoiesis declines. Understanding the composition of the PVS is therefore vital to understanding mechanisms of thymic atrophy. We have analyzed 87 normal and 31 myasthenia ... Full text Link to item Cite

Possible extrathymic development of nonfunctional T cells in a patient with complete DiGeorge syndrome.

Journal Article Clin Immunol · May 1999 Complete DiGeorge syndrome is characterized by the clinical triad of cardiac malformation, hypocalcemia, and T cell immunodeficiency due to congenital athymia. We describe an infant with complete DiGeorge syndrome who at presentation had no circulating T c ... Full text Link to item Cite

Thymic function, aging, and AIDS.

Journal Article Hosp Pract (1995) · March 15, 1999 For the first time, physicians are challenged by clinical states in which the T-cell pool is destroyed postnatally in large numbers of patients. One such state is AIDS; another is the immune damage of cancer chemotherapy. Accordingly, study of postnatal th ... Full text Link to item Cite

Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection.

Journal Article J Clin Invest · February 1999 A key question in understanding the status of the immune system in HIV-1 infection is whether the adult thymus contributes to reconstitution of peripheral T lymphocytes. We analyzed the thymus in adult patients who died of HIV-1 infection. In addition, we ... Full text Link to item Cite

Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.

Journal Article Proc Natl Acad Sci U S A · July 21, 1998 Angiogenesis is required for tumor growth and metastasis, and inhibition of angiogenesis is a promising approach for anticancer therapy. Tie2 (a.k.a Tek) is an endothelium-specific receptor tyrosine kinase known to play a role in tumor angiogenesis. To exp ... Full text Link to item Cite

Local production of TGF beta1 inhibits cerebral edema, enhances TNF-alpha induced apoptosis and improves survival in a murine glioma model.

Journal Article J Neuroimmunol · June 1, 1998 We have previously reported that local secretion of either TNF-alpha or TGF beta1 by intracerebral SMA-560 malignant glioma tumor cells can reduce or eliminate tumor growth in mice. However, the use of TNF-alpha, while improving the overall survival of tum ... Full text Link to item Cite

Analysis of DNA mismatch repair proteins in human medulloblastoma.

Journal Article Clin Cancer Res · June 1998 During replication, the primary function of the eukaryotic DNA mismatch repair (MMR) system is to recognize and correct mismatched base pairs within the DNA helix. Deficiencies in MMR have been reported previously in cases of hereditary nonpolyposis colore ... Link to item Cite

Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms.

Journal Article Genomics · February 1, 1998 The investigation of a DNase-hypersensitive site upstream of the CD7 gene on chromosome 17q25 has led to the discovery of a novel human gene designated K12 (SECTM1, the HGMW assignment). This gene spans approximately 14 kb and encodes a 1.8-kb mRNA detecte ... Full text Link to item Cite

Endogenous expression of transforming growth factor beta1 inhibits growth and tumorigenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model.

Journal Article Cancer Res · January 15, 1998 It has been hypothesized that transforming growth factor beta (TGF-beta) may prevent immune-mediated glioma cell elimination; however, previous work has also indicated that increased TGF-beta may lead to reduced proliferation, induction of apoptosis, and e ... Link to item Cite

The human thymus. A chimeric organ comprised of central and peripheral lymphoid components.

Journal Article Immunol Res · 1998 The human thymus is a lymphoepithelial organ in which T cells develop during fetal life. After maturation and selection in the fetal thymic microenvironment, T cells emigrate to peripheral lymphoid tissues such as the spleen, gut, and lymph nodes, and esta ... Full text Link to item Cite

The human thymus. A chimeric organ comprised of central and peripheral lymphoid components.

Journal Article Immunol Res · 1998 The human thymus is a lymphoepithelial organ in which T cells develop during fetal life. After maturation and selection in the fetal thymic microenvironment, T cells emigrate to peripheral lymphoid tissues such as the spleen, gut, and lymph nodes, and esta ... Full text Link to item Cite

Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion.

Journal Article Neurosurgery · December 1997 OBJECTIVE: The promise of immunotherapies developed against brain tumors in animal models has not been realized in human clinical trials. This may be because of the routine use of rodent tumors artificially induced by chemicals or viruses that do not accur ... Full text Link to item Cite

Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors.

Journal Article J Exp Med · October 6, 1997 Recent studies have shown that the brain is not a barrier to successful active immunotherapy that uses gene-modified autologous tumor cell vaccines. In this study, we compared the efficacy of two types of vaccines for the treatment of tumors within the cen ... Full text Link to item Cite

A genetically modified allogeneic cellular vaccine generates MHC class I-restricted cytotoxic responses against tumor-associated antigens and protects against CNS tumors in vivo.

Journal Article J Neuroimmunol · September 1997 An active immunotherapeutic strategy using transfected allogeneic cells for targeting the mutant epidermal growth factor receptor (EGFRvIII) on intracranial tumors was examined. Immunization with allogeneic 300.19/EGFRvIII cells induced CD8+ cytotoxic T-ly ... Full text Link to item Cite

Expression of CD44 and variant isoforms in cultured human retinal pigment epithelial cells.

Journal Article Invest Ophthalmol Vis Sci · September 1997 PURPOSE: CD44 is a major hyaluronic acid receptor that exists as a number of isoforms, generated by alternative splicing of 9 "variant" exons in humans (v2 to v10) and 10 exons in rodents. Little is known about the expression and function of CD44 in human ... Link to item Cite

Not a "bee-zoar," but a wasp.

Journal Article N Engl J Med · August 21, 1997 Full text Link to item Cite

L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice.

Journal Article J Immunol · June 1, 1997 Adhesion of leukocytes to vascular endothelium is crucial for leukocyte migration into tissues. The contributions of L-selectin, P-selectin, and ICAM-1 to interactions between lymphocytes and endothelium was examined using allogeneic skin graft rejection a ... Link to item Cite

Normalization of the peripheral blood T cell receptor V beta repertoire after cultured postnatal human thymic transplantation in DiGeorge syndrome.

Journal Article J Clin Immunol · March 1997 Complete DiGeorge syndrome is an immunodeficiency disease characterized by thymic aplasia and the absence of functioning peripheral T cells. A patient with this syndrome was transplanted with cultured postnatal human thymic tissue. Within 5 weeks of transp ... Full text Link to item Cite

Successful formation of a chimeric human thymus allograft following transplantation of cultured postnatal human thymus.

Journal Article J Immunol · January 15, 1997 Transplantation of cultured postnatal human thymus was performed in a patient with complete DiGeorge syndrome. Biopsy of the graft 3 mo after implantation revealed normal CD1+ thymocytes in thymic cortical epithelial regions and CD1- thymocytes in thymic m ... Link to item Cite

The human thymic microenvironment during organ culture.

Journal Article Clin Immunol Immunopathol · January 1997 Cultured human thymic tissue has been transplanted into many patients with T cell dysfunction; however, little is known about the effect of in vitro culture on thymic tissue. Human postnatal thymic organ cultures were established in vitro to study the grow ... Full text Link to item Cite

Role of L-selectin in lymphocyte migration to cutaneous sites of inflammation.

Journal Article JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY · January 1, 1997 Link to item Cite

Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system.

Journal Article Proc Natl Acad Sci U S A · September 17, 1996 Vaccination with cytokine-producing tumor cells generates potent immune responses against tumors outside the central nervous system (CNS). The CNS, however, is a barrier to allograft and xenograft rejection, and established tumors within the CNS have faile ... Full text Link to item Cite

Thymic transplantation for digeorge syndrome.

Journal Article FASEB JOURNAL · April 30, 1996 Link to item Cite

Distribution of CD44 variant isoforms in human skin: differential expression in components of benign and malignant epithelia.

Journal Article J Cutan Pathol · December 1995 Expression of cell adhesion molecules regulates epithelial cell differentiation and organization of complex tissues such as skin. The CD44 family of adhesion molecules is generated by alternative splicing of up to 10 variant exons encoding inserts into the ... Full text Link to item Cite

DEVELOPMENT OF T-CELL FUNCTION AFTER POSTNATAL THYMIC TRANSPLANTATION FOR DIGEORGE-SYNDROME

Journal Article AMERICAN JOURNAL OF HUMAN GENETICS · October 1, 1995 Link to item Cite

Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas.

Journal Article Cancer Res · July 15, 1995 Despite molecular biological advances in understanding human cancers, translation into therapy has been less forthcoming; targeting neoplastic cells still requires that tumor-specific markers, preferably those on the cell surface, be identified. The epider ... Link to item Cite

In vitro induction of primary, antigen-specific CTL from human peripheral blood mononuclear cells stimulated with synthetic peptides.

Journal Article Mol Immunol · June 1995 A protocol for in vitro induction of primary, antigen-specific CTL from human peripheral blood mononuclear cells (PBMCs) was developed. Antigen presenting cells (APCs) consisted of Staphylococcus aureus Cowan-I (SAC-I) activated PBMCs treated with a citrat ... Full text Link to item Cite

Expression of CD44 molecules and CD44 ligands during human thymic fetal development: expression of CD44 isoforms is developmentally regulated.

Journal Article Int Immunol · February 1995 It has recently been recognized that CD44 comprises a large family of alternatively spliced forms. In the thymus, CD44 has been postulated to play an important role in immature T cell migration and maturation. In this paper, we have studied the expression ... Full text Link to item Cite

Infantile sialic acid storage disease: a rare cause of cytoplasmic vacuolation in pediatric patients.

Journal Article Pediatr Pathol Lab Med · 1995 We report a case of infantile sialic acid storage disease (ISSD) in a black infant presenting in utero with nonimmune hydrops, ascites, and anemia requiring intrauterine transfusion. Upon birth, the patient had prominent edema, large anterior fontanelle, p ... Full text Link to item Cite

Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation.

Journal Article J Immunol · December 15, 1992 Treatment of T cells with the cysteine protease bromelain has been widely used to enhance the binding of human T cells to human E (autologous E rosettes) and has been shown to remove surface T cell CD44 molecules. Ligand binding to CD44 has been shown to m ... Link to item Cite

Measurement of an adhesion molecule as an indicator of inflammatory disease activity. Up-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis.

Journal Article Arthritis Rheum · November 1991 The hyaluronate receptor (CD44) molecule is a multifunctional cell surface protein involved in T cell activation, monocyte cytokine release, fibroblast locomotion, and lymphocyte binding to high endothelial venules. To study the roles CD44 molecules play i ... Full text Link to item Cite

CD44 antibody against In(Lu)-related p80, lymphocyte-homing receptor molecule inhibits the binding of human erythrocytes to T cells.

Journal Article J Immunol · December 15, 1989 The cluster of differentiation 44 (CD44) Ag system, originally described in brain and mature T cells, has been subsequently shown to be identical with the human lymphocyte homing-receptor defined by the Hermes-1 antibody and to be involved in T cell/endoth ... Link to item Cite

CD44--a molecule involved in leukocyte adherence and T-cell activation.

Journal Article Immunol Today · December 1989 The study of cell surface molecules that are involved in interactions between immune and non-hematopoietic cells in various microenvironments is currently an area of great interest. One molecule that appears to be involved in multiple steps of normal immun ... Full text Link to item Cite

Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment.

Journal Article Arthritis Rheum · January 1989 Antigen-independent binding of T lymphocytes to a variety of cell types has been shown to be mediated by receptor-ligand pairs of adhesion molecules. In forms of inflammatory synovitis (including rheumatoid arthritis), T cells home to synovium, become acti ... Full text Link to item Cite

Synovial microenvironment-T cell interactions. Human T cells bind to fibroblast-like synovial cells in vitro.

Journal Article Arthritis Rheum · August 1988 Synovitis in rheumatoid arthritis is characterized by infiltration of the synovium by T and B lymphocytes and monocytes, as well as by the proliferation of synovial lining cells, fibroblasts, and endothelial cells. To study synovial cell-T cell interaction ... Full text Link to item Cite