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Michael Lucas James

Michael Lucas James

Professor of Anesthesiology
Anesthesiology, Neuroanesthesia
michael.james@duke.edu
Box 3094 Med Ctr, Durham, NC 27710
5619D Hafs Building, Durham, NC 27710

Selected Publications

Fostering Global Research Collaborations: An Update on Duke-NUS Medical School, the Duke University and National University of Singapore Partnership.

Journal Article Acad Med · February 26, 2025 PROBLEM: Navigating the complexities of international research collaborations is a challenge. This article provides a detailed examination of the international collaboration between Duke University and the National University of Singapore to establish the ... Full text Link to item Cite

Neurocognitive Dysfunction After Short (<20 Minutes) Duration Hypothermic Circulatory Arrest.

Journal Article Ann Thorac Surg · February 2025 BACKGROUND: It has long been held that the safe duration of hypothermic circulatory arrest (HCA) is at least 25 to 30 minutes. However, this belief is based primarily on clinical outcomes research and has not been systematically investigated using more sen ... Full text Link to item Cite

Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Outcomes and  Endpoints.

Journal Article Neurocrit Care · October 2024 BACKGROUND: Clinical management of persons with disorders of consciousness (DoC) is dedicated largely to optimizing recovery. However, selecting a measure to evaluate the extent of recovery is challenging because few measures are designed to precisely asse ... Full text Link to item Cite

Early Beta-Blocker Utilization in Critically Ill Patients With Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study.

Journal Article J Intensive Care Med · September 2024 BACKGROUND: There is limited evidence that beta-blockers may provide benefit for patients with moderate-severe traumatic brain injury (TBI) during the acute injury period. Larger studies on utilization patterns and impact on outcomes in clinical practice a ... Full text Link to item Cite

Association of Early Dexmedetomidine Utilization With Clinical Outcomes After Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study.

Journal Article Anesth Analg · August 1, 2024 BACKGROUND: Traumatic brain injury (TBI) is an expensive and common public health problem. Management of TBI oftentimes includes sedation to facilitate mechanical ventilation (MV) for airway protection. Dexmedetomidine has emerged as a potential candidate ... Full text Link to item Cite

Association of early dexmedetomidine exposure with brain injury biomarker levels following moderate - Severe traumatic brain injury: A TRACK-TBI study.

Journal Article J Clin Neurosci · August 2024 BACKGROUND: Traumatic brain injury (TBI) triggers autonomic dysfunction and inflammatory response that can result in secondary brain injuries. Dexmedetomidine is an alpha-2 agonist that may modulate autonomic function and inflammation and has been increasi ... Full text Link to item Cite

Association of Early Dexmedetomidine Utilization With Clinical and Functional Outcomes Following Moderate-Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study.

Journal Article Crit Care Med · April 1, 2024 OBJECTIVE: To examine early sedation patterns, as well as the association of dexmedetomidine exposure, with clinical and functional outcomes among mechanically ventilated patients with moderate-severe traumatic brain injury (msTBI). DESIGN: Retrospective c ... Full text Link to item Cite

Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest Trial (GOT ICE): A Randomized Clinical Trial Comparing Outcomes After Aortic Arch Surgery.

Journal Article Circulation · February 27, 2024 BACKGROUND: Deep hypothermia has been the standard for hypothermic circulatory arrest (HCA) during aortic arch surgery. However, centers worldwide have shifted toward lesser hypothermia with antegrade cerebral perfusion. This has been supported by retrospe ... Full text Link to item Cite

The impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement.

Journal Article J Thorac Cardiovasc Surg · February 2024 OBJECTIVE: The effects of stroke and delirium on postdischarge cognition and patient-centered health outcomes after surgical aortic valve replacement (SAVR) are not well characterized. Here, we assess the impact of postoperative stroke and delirium on thes ... Full text Link to item Cite

Deep Resequencing of the 1q22 Locus in Non-Lobar Intracerebral Hemorrhage.

Journal Article Ann Neurol · February 2024 OBJECTIVE: Genome-wide association studies have identified 1q22 as a susceptibility locus for cerebral small vessel diseases, including non-lobar intracerebral hemorrhage (ICH) and lacunar stroke. In the present study, we performed targeted high-depth sequ ... Full text Link to item Cite

Association Between Body Mass Index and Functional Outcomes in Patients With Intracerebral Hemorrhage.

Journal Article Neurology · January 23, 2024 BACKGROUND AND OBJECTIVES: Evidence of the so-called "obesity paradox," which refers to the protective effect and survival benefit of obesity in patients with spontaneous intracerebral hemorrhage (ICH), remains controversial. This study aims to determine t ... Full text Link to item Cite

Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Hospital Course, Confounders, and Medications.

Journal Article Neurocrit Care · December 2023 The convergence of an interdisciplinary team of neurocritical care specialists to organize the Curing Coma Campaign is the first effort of its kind to coordinate national and international research efforts aimed at a deeper understanding of disorders of co ... Full text Link to item Cite

Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Neuroimaging.

Journal Article Neurocrit Care · December 2023 BACKGROUND: Over the past 5 decades, advances in neuroimaging have yielded insights into the pathophysiologic mechanisms that cause disorders of consciousness (DoC) in patients with severe brain injuries. Structural, functional, metabolic, and perfusion im ... Full text Link to item Cite

PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior.

Journal Article Neuron · September 6, 2023 Programmed death protein 1 (PD-1) and its ligand PD-L1 constitute an immune checkpoint pathway. We report that neuronal PD-1 signaling regulates learning/memory in health and disease. Mice lacking PD-1 (encoded by Pdcd1) exhibit enhanced long-term potentia ... Full text Link to item Cite

Association of Early Beta-Blocker Exposure and Functional Outcomes in Critically Ill Patients With Moderate to Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study.

Journal Article Crit Care Explor · September 2023 OBJECTIVES: We aimed to 1) describe patterns of beta-blocker utilization among critically ill patients following moderate-severe traumatic brain injury (TBI) and 2) examine the association of early beta-blocker exposure with functional and clinical outcome ... Full text Open Access Link to item Cite

Hyperglycemia, Ischemic Lesions, and Functional Outcomes After Intracerebral Hemorrhage.

Journal Article J Am Heart Assoc · July 4, 2023 Background Ischemic lesions observed on diffusion-weighted imaging (DWI) magnetic resonance imaging are associated with poor outcomes after intracerebral hemorrhage (ICH). We evaluated the association between hyperglycemia, ischemic lesions, and functional ... Full text Link to item Cite

Association of Brain Injury Biomarkers and Circulatory Shock Following Moderate-Severe Traumatic Brain Injury: A TRACK-TBI Study.

Journal Article J Neurosurg Anesthesiol · July 1, 2023 INTRODUCTION: Early circulatory shock following traumatic brain injury (TBI) is a multifactorial process; however, the impact of brain injury biomarkers on the risk of shock has not been evaluated. We examined the association between neuronal injury biomar ... Full text Open Access Link to item Cite

Utilization and Outcomes of Extracorporeal Membrane Oxygenation Following Traumatic Brain Injury in the United States.

Journal Article J Intensive Care Med · May 2023 Objectives: Describe contemporary ECMO utilization patterns among patients with traumatic brain injury (TBI) and examine clinical outcomes among TBI patients requiring ECMO. Design: Retrospective cohort study. Setting: Premier Healthcare Database (PHD) bet ... Full text Link to item Cite

Deep resequencing of the 1q22 locus in non-lobar intracerebral hemorrhage.

Journal Article medRxiv · April 24, 2023 OBJECTIVE: Genome-wide association studies have identified 1q22 as a susceptibility locus for cerebral small vessel diseases (CSVDs), including non-lobar intracerebral hemorrhage (ICH) and lacunar stroke. In the present study we performed targeted high-dep ... Full text Link to item Cite

Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling.

Journal Article JCI Insight · December 8, 2022 High endothelial venule protein/SPARC-like 1 (hevin/Sparcl1) is an astrocyte-secreted protein that regulates synapse formation in the brain. Here we show that astrocytic hevin signaling plays a critical role in maintaining chronic pain. Compared with WT mi ... Full text Open Access Link to item Cite

Early Vasopressor Utilization Strategies and Outcomes in Critically Ill Patients With Severe Traumatic Brain Injury.

Journal Article Anesth Analg · December 1, 2022 BACKGROUND: Early hypotension after severe traumatic brain injury (sTBI) is associated with increased mortality and poor long-term outcomes. Current guidelines suggest the use of intravenous vasopressors, commonly norepinephrine and phenylephrine, to suppo ... Full text Link to item Cite

Initial antihypertensive agent effects on acute blood pressure after intracerebral haemorrhage.

Journal Article Stroke Vasc Neurol · October 2022 INTRODUCTION: Current guidelines recommend blood pressure (BP) lowering in patients after acute intracerebral haemorrhage (ICH) without guidance on initial choice of antihypertensive class. This study sought to determine if initial antihypertensive class d ... Full text Link to item Cite

In vivo single microglial cell isolation after intracerebral hemorrhage in mice.

Journal Article Neurosci Lett · September 14, 2022 Failure to translate promising potential therapeutics for intracerebral hemorrhage (ICH) partially results from limited understanding of cellular mechanisms underlying brain injury and repair. Understanding neural repair mechanisms after brain injury requi ... Full text Link to item Cite

Risk Factors and Neurological Outcomes Associated With Circulatory Shock After Moderate-Severe Traumatic Brain Injury: A TRACK-TBI Study.

Journal Article Neurosurgery · September 1, 2022 BACKGROUND: Extracranial multisystem organ failure is a common sequela of severe traumatic brain injury (TBI). Risk factors for developing circulatory shock and long-term functional outcomes of this patient subset are poorly understood. OBJECTIVE: To ident ... Full text Link to item Cite

An Exploratory Analysis of Biomarkers of Perihematomal Edema in the CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial.

Journal Article J Stroke Cerebrovasc Dis · August 2022 OBJECTIVE: To identify biomarkers with potential to indicate severity of perihematomal edema and secondary tissue injury after intracerebral hemorrhage (ICH), and which could be used as surrogate markers in future clinical trials for novel ICH therapeutics ... Full text Link to item Cite

Mechanical thrombectomy for perioperative ischemic stroke following elective inpatient surgery in the United States.

Journal Article J Clin Neurosci · July 2022 Perioperative ischemic stroke significantly increases morbidity and mortality in patients undergoing elective surgery. Mechanical thrombectomy can improve ischemic stroke outcomes, but frequency and trend of its utilization for treatment of perioperative i ... Full text Open Access Link to item Cite

Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation: The SETPOINT2 Randomized Clinical Trial.

Journal Article JAMA · May 17, 2022 IMPORTANCE: Many patients with severe stroke have impaired airway protective reflexes, resulting in prolonged invasive mechanical ventilation. OBJECTIVE: To test whether early vs standard tracheostomy improved functional outcome among patients with stroke ... Full text Link to item Cite

Coupling Hematoma Evacuation with Immune Profiling for Analysis of Neuroinflammation After Primary Intracerebral Hemorrhage: A Pilot Study.

Journal Article World Neurosurg · May 2022 OBJECTIVE: We sought to explore the use and feasibility of an integrated hematoma evacuation/tissue preservation system coupled with immune profiling to assess human ex vivo immune cell populations from brain hematoma samples after intracerebral hemorrhage ... Full text Link to item Cite

Incidence and Clinical Impact of Myocardial Injury Following Traumatic Brain Injury: A Pilot TRACK-TBI Study.

Journal Article J Neurosurg Anesthesiol · April 1, 2022 BACKGROUND: Traumatic brain injury (TBI) is a major global health problem. Little research has addressed extracranial organ dysfunction following TBI, particularly myocardial injury. Using a sensitive marker of myocardial injury-high sensitivity troponin ( ... Full text Link to item Cite

Utilization of Brain Tissue Oxygenation Monitoring and Association with Mortality Following Severe Traumatic Brain Injury.

Journal Article Neurocrit Care · April 2022 BACKGROUND: The aim of this study was to describe the utilization patterns of brain tissue oxygen (PbtO2) monitoring following severe traumatic brain injury (TBI) and determine associations with mortality, health care use, and pulmonary toxicity. METHODS: ... Full text Open Access Link to item Cite

Risk Factors Associated With Mortality and Neurologic Disability After Intracerebral Hemorrhage in a Racially and Ethnically Diverse Cohort.

Journal Article JAMA Netw Open · March 1, 2022 INTRODUCTION: Intracerebral hemorrhage (ICH) is the most severe subtype of stroke. Its mortality rate is high, and most survivors experience significant disability. OBJECTIVE: To assess primary patient risk factors associated with mortality and neurologic ... Full text Link to item Cite

Association of Vasopressor Choice with Clinical and Functional Outcomes Following Moderate to Severe Traumatic Brain Injury: A TRACK-TBI Study.

Journal Article Neurocrit Care · February 2022 BACKGROUND: Early hypotension following moderate to severe traumatic brain injury (TBI) is associated with increased mortality and poor long-term outcomes. Current guidelines suggest the use of intravenous vasopressors to support blood pressure following T ... Full text Link to item Cite

CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial.

Journal Article Neurocrit Care · February 2022 BACKGROUND: Endogenous apolipoprotein (apo) E mediates neuroinflammatory responses and recovery after brain injury. Exogenously administered apoE-mimetic peptides effectively penetrate the central nervous system compartment and downregulate acute inflammat ... Full text Open Access Link to item Cite

Identifying risk factors of intracerebral hemorrhage stability using explainable attention model.

Journal Article Med Biol Eng Comput · February 2022 Segmentation of intracerebral hemorrhage (ICH) helps improve the quality of diagnosis, draft the desired treatment methods, and clinically observe the variations with healthy patients. The clinical utilization of various ICH progression scoring systems has ... Full text Link to item Cite

Abstract TP133: Diabetes/hyperglycemia Is Associated With Poor Six-month Functional Outcomes, But Is Not Associated With The Development Of Microvascular Ischemic Lesions After Intracerebral Hemorrhage

Conference Stroke · February 2022 Introduction: Ischemic lesions seen on diffusion weighted imaging (DWI) are associated with worsened outcomes after intracerebral hemorrhage (ICH) and are thought to arise due to microvascular damage. ... Full text Cite

Epidemiology and Outcomes of Acute Respiratory Distress Syndrome Following Isolated Severe Traumatic Brain Injury.

Journal Article J Intensive Care Med · January 2022 Patients with traumatic brain injury (TBI) are at risk for extra-cranial complications, such as the acute respiratory distress syndrome (ARDS). We conducted an analysis of risk factors, mortality, and healthcare utilization associated with ARDS following i ... Full text Open Access Link to item Cite

Andexanet alfa and four-factor prothrombin complex concentrate for reversal of apixaban and rivaroxaban in patients diagnosed with intracranial hemorrhage.

Journal Article J Thromb Thrombolysis · January 2022 Limited data exists regarding the clinical outcomes of andexanet alfa and four factor prothrombin complex concentrate (4F-PCC) for reversal of apixaban or rivaroxaban in the setting of intracranial hemorrhage (ICH). The objective of this study was to evalu ... Full text Link to item Cite

Association of Severe Acute Kidney Injury with Mortality and Healthcare Utilization Following Isolated Traumatic Brain Injury.

Journal Article Neurocrit Care · October 2021 BACKGROUND/OBJECTIVE: Traumatic brain injury (TBI) is a leading cause of morbidity, mortality, and disability in the USA. While cardiopulmonary dysfunction can result in poor outcomes following severe TBI, the impact of acute kidney injury (AKI) is poorly ... Full text Open Access Link to item Cite

Neuroprotective Pentapeptide, CN-105, Improves Outcomes in Translational Models of Intracerebral Hemorrhage.

Journal Article Neurocrit Care · October 2021 BACKGROUND: Intracerebral hemorrhage (ICH) is a devastating form of cerebrovascular disease for which there are no approved pharmacological interventions that improve outcomes. Apolipoprotein E (apoE) has emerged as a promising therapeutic target given its ... Full text Link to item Cite

Association of Early Multiple Organ Dysfunction With Clinical and Functional Outcomes Over the Year Following Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study.

Journal Article Crit Care Med · October 1, 2021 OBJECTIVES: Traumatic brain injury is a leading cause of death and disability in the United States. While the impact of early multiple organ dysfunction syndrome has been studied in many critical care paradigms, the clinical impact of early multiple organ ... Full text Link to item Cite

Anticoagulation after Spontaneous Intraparenchymal Hemorrhage in Patients with Mechanical Heart Valves and Concomitant Atrial Fibrillation

Journal Article Journal of Neuroanaesthesiology and Critical Care · September 1, 2021 Aim Patients with mechanical heart valves and coexisting atrial fibrillation (AFib-MHV) who suffer an intraparenchymal hemorrhage (IPH, defined as bleeding solely within the brain parenchyma and/or ventricle) are at a high risk of thromboembolism without a ... Full text Cite

Ethnic and Racial Variation in Intracerebral Hemorrhage Risk Factors and Risk Factor Burden.

Journal Article JAMA Netw Open · August 2, 2021 IMPORTANCE: Black and Hispanic individuals have an increased risk of intracerebral hemorrhage (ICH) compared with their White counterparts, but no large studies of ICH have been conducted in these disproportionately affected populations. OBJECTIVE: To exam ... Full text Link to item Cite

Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.

Journal Article Neurocrit Care · July 2021 Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to or ... Full text Link to item Cite

Echocardiogram Utilization Patterns and Association With Mortality Following Severe Traumatic Brain Injury.

Journal Article Anesth Analg · April 1, 2021 BACKGROUND: Severe traumatic brain injury (TBI) can result in left ventricular dysfunction, which can lead to hypotension and secondary brain injuries. Although echocardiography is often used to examine cardiovascular function in multiple clinical settings ... Full text Open Access Link to item Cite

A Triage Model for Interhospital Transfers of Low Risk Intracerebral Hemorrhage Patients.

Journal Article J Stroke Cerebrovasc Dis · April 2021 OBJECTIVES: Intracerebral hemorrhage comprises a large proportion of inter-hospital transfers to comprehensive stroke centers from centers without comprehensive stroke center resources despite lack of mortality benefit and low comprehensive stroke center r ... Full text Link to item Cite

Associations between Features of External Ventricular Drain Management, Disposition, and Shunt Dependence

Journal Article Journal of Neuroanaesthesiology and Critical Care · March 1, 2021 Background In the United States, nearly 25,000 patients annually undergo percutaneous ventriculostomy for the management of increased intracranial pressure with little consensus on extraventricular drain management. To characterize relationships between ex ... Full text Open Access Cite

Abstract P527: Temporal Trend of Mechanical Thrombectomy Utilization in Treatment of Perioperative Ischemic Stroke Following Elective Inpatient Surgery in the United States

Conference Stroke · March 2021 Background: Perioperative ischemic stroke (PIS) significantly increases morbidity and mortality in patients undergoing elective surgery. Mechanical thrombectomy (MT) can improve outcomes of ischemic s ... Full text Cite

Neurosurgery

Chapter · February 2021 Written and edited by recognized authorities in anesthesiology and surgical critical care, this fully updated edition helps you think critically about complex, long-term issues surrounding the care of the surgical patient, providing ... ... Cite

Carotid and Intracranial Surgery

Chapter · January 1, 2021 Carotid surgeries that are performed to prevent strokes are carotid endarterectomy (CEA), carotid angioplasty/stenting, and transcarotid artery revascularization. CEA is the most frequently performed surgical procedure to prevent stroke in the United State ... Full text Cite

The Magnitude of Blood Pressure Reduction Predicts Poor In-Hospital Outcome in Acute Intracerebral Hemorrhage.

Journal Article Neurocrit Care · October 2020 BACKGROUND: Early systolic blood pressure (SBP) reduction is believed to improve outcome after spontaneous intracerebral hemorrhage (ICH), but there has been a limited assessment of SBP trajectories in individual patients. We aimed to determine the prognos ... Full text Link to item Cite

Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage.

Journal Article Stroke · July 2020 BACKGROUND AND PURPOSE: For survivors of oral anticoagulation therapy (OAT)-associated intracerebral hemorrhage (OAT-ICH) who are at high risk for thromboembolism, the benefits of OAT resumption must be weighed against increased risk of recurrent hemorrhag ... Full text Link to item Cite

Author Correction: Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage.

Journal Article Sci Rep · April 20, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

Selective Serotonin Reuptake Inhibitors and Intracerebral Hemorrhage Risk and Outcome.

Journal Article Stroke · April 2020 Background and Purpose- Selective serotonin reuptake inhibitors (SSRIs) have a well-established association with bleeding complications and conflicting reports on outcome after stroke. We sought to evaluate whether pre-intracerebral hemorrhage (ICH) SSRI u ... Full text Link to item Cite

Therapeutic Development of Apolipoprotein E Mimetics for Acute Brain Injury: Augmenting Endogenous Responses to Reduce Secondary Injury.

Journal Article Neurotherapeutics · April 2020 Over the last few decades, increasing evidence demonstrates that the neuroinflammatory response is a double-edged sword. Although overly robust inflammatory responses may exacerbate secondary tissue injury, inflammatory processes are ultimately necessary f ... Full text Open Access Link to item Cite

Neuroprotective pentapeptide, CN-105, improves outcomes in translational models of intracerebral hemorrhage

Journal Article · 2020 Background Intracerebral hemorrhage (ICH) is a devastating form of cerebrovascular disease for which there are no approved pharmacological interventions that improve outcomes. Apolipoprotein E (apoE) has emerged as a promising therapeutic target g ... Full text Cite

Impact of Cerebral Small Vessel Disease on Functional Recovery After Intracerebral Hemorrhage.

Journal Article Stroke · October 2019 Background and Purpose- In this study, we aim to investigate the association of computed tomography-based markers of cerebral small vessel disease with functional outcome and recovery after intracerebral hemorrhage. Methods- Computed tomographic scans of p ... Full text Link to item Cite

Paradox of age: older patients receive higher age-adjusted minimum alveolar concentration fractions of volatile anaesthetics yet display higher bispectral index values.

Journal Article Br J Anaesth · September 2019 BACKGROUND: Minimum alveolar concentration (MAC) and MAC-awake decrease with age. We hypothesised that, in clinical practice, (i) end-tidal MAC fraction in older patients would decline by less than the predicted age-dependent MAC decrease (i.e. older patie ... Full text Link to item Cite

Blood Pressure Variability Predicts Poor In-Hospital Outcome in Spontaneous Intracerebral Hemorrhage.

Journal Article Stroke · August 2019 Background and Purpose- There is increasing evidence that higher systolic blood pressure variability (SBPV) may be associated with poor outcome in patients with intracerebral hemorrhage (ICH). We explored the association between SBPV and in-hospital ICH ou ... Full text Link to item Cite

Venous Thromboembolism in Patients With Spontaneous Intracerebral Hemorrhage: A Multicenter Study.

Journal Article Neurosurgery · June 1, 2019 BACKGROUND: Patients with spontaneous intracerebral hemorrhage (ICH) are predisposed to venous thromboembolic (VTE) complications, such as deep vein thrombosis and pulmonary embolism. OBJECTIVE: To evaluate, in a multicenter, retrospective cohort study, th ... Full text Link to item Cite

Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure.

Journal Article Neurosurgery · June 1, 2019 BACKGROUND: Minimally invasive surgery procedures, including stereotactic catheter aspiration and clearance of intracerebral hemorrhage (ICH) with recombinant tissue plasminogen activator hold a promise to improve outcome of supratentorial brain hemorrhage ... Full text Link to item Cite

Cerebral Venous Thrombosis: Reviewing Pathophysiology, Diagnosis, and Treatment Strategies

Journal Article Journal of Neuroanaesthesiology and Critical Care · June 2019 AbstractThis review discusses cerebral venous thrombosis (CVT), including diagnosis and treatment strategies, a rare class of stroke that, if unrecognized or untreated, can have devastating effects. Thrombosis of one or man ... Full text Cite

Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial.

Journal Article Lancet Neurol · May 2019 BACKGROUND: Iron from haemolysed blood is implicated in secondary injury after intracerebral haemorrhage. We aimed to assess the safety of the iron chelator deferoxamine mesylate in patients with intracerebral haemorrhage and to establish whether the drug ... Full text Link to item Cite

Sex Differences in Gene and Protein Expression After Intracerebral Hemorrhage in Mice.

Journal Article Transl Stroke Res · April 2019 Sex dimorphism has been demonstrated after experimental intracerebral hemorrhage (ICH). Decreased mortality and improved neurobehavioral outcomes occur in female compared to male mice after intrastriatal autologous blood or collagenase injection. Sex-speci ... Full text Link to item Cite

External Validation of Hematoma Expansion Scores in Spontaneous Intracerebral Hemorrhage in an Asian Patient Cohort.

Journal Article Neurocrit Care · April 2019 BACKGROUND: Hematoma expansion (HE) occurs in approximately one-third of patients with intracerebral hemorrhage (ICH) and is known to be a strong predictor of neurological deterioration as well as poor functional outcome. This study aims to externally vali ... Full text Link to item Cite

Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis.

Journal Article JAMA Neurol · April 1, 2019 IMPORTANCE: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify t ... Full text Link to item Cite

Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial.

Journal Article Lancet · March 9, 2019 BACKGROUND: Acute stroke due to supratentorial intracerebral haemorrhage is associated with high morbidity and mortality. Open craniotomy haematoma evacuation has not been found to have any benefit in large randomised trials. We assessed whether minimally ... Full text Link to item Cite

Renal Angina Is a Sensitive, but Nonspecific Identifier of Postcardiac Surgery Acute Kidney Injury.

Journal Article J Cardiothorac Vasc Anesth · February 2019 OBJECTIVES: Acute kidney injury (AKI) is a common complication of cardiac surgery, and early detection is difficult. This study was performed to determine the sensitivity, specificity, positive predictive value, negative predictive value, and statistical p ... Full text Link to item Cite

Spinal cord injury pharmacotherapy: Current research & development and competitive commercial landscape as of 2015.

Journal Article J Spinal Cord Med · January 2019 CONTEXT: Current treatment of spinal cord injury (SCI) focuses on cord stabilization to prevent further injury, rehabilitation, management of non-motor symptoms, and prevention of complications. Currently, no approved treatments are available, and limited ... Full text Link to item Cite

Longitudinal Changes in Regional Cerebral Perfusion and Cognition After Cardiac Operation.

Journal Article Ann Thorac Surg · January 2019 BACKGROUND: Cardiac operation has been associated with increased risk of postoperative cognitive decline, as well as dementia risk in the general population. Few studies, however, have examined the impact of coronary revascularization or valve replacement ... Full text Open Access Link to item Cite

ICHNet: Intracerebral hemorrhage (ICH) segmentation using deep learning

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2019 We develop a deep learning approach for automated intracerebral hemorrhage (ICH) segmentation from 3D computed tomography (CT) scans. Our model, ICHNet, evolves by integrating dilated convolution neural network (CNN) with hypercolumn features where a modes ... Full text Cite

Minority Patients are Less Likely to Undergo Withdrawal of Care After Spontaneous Intracerebral Hemorrhage.

Journal Article Neurocrit Care · December 2018 BACKGROUND: Prior studies of patients in the intensive care unit have suggested racial/ethnic variation in end-of-life decision making. We sought to evaluate whether race/ethnicity modifies the implementation of comfort measures only status (CMOs) in patie ... Full text Link to item Cite

Long-term recovery profile of patients with severe disability or in vegetative states following severe primary intracerebral hemorrhage.

Journal Article J Crit Care · December 2018 PURPOSE: We conducted a single-center retrospective review to investigate the long-term recovery of patients who were severely disabled or vegetative secondary to primary intracerebral hemorrhage upon discharge from hospital from January 2009 to November 2 ... Full text Link to item Cite

Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage.

Journal Article Stroke · November 2018 Background and Purpose- Whether to resume oral anticoagulation treatment after intracerebral hemorrhage (ICH) remains an unresolved question. Previous studies focused primarily on recurrent stroke after ICH. We sought to investigate the association between ... Full text Link to item Cite

Associations between Patient Characteristics and a New, Early Do-Not-Attempt Resuscitation Order after Intracerebral Hemorrhage.

Journal Article J Palliat Med · August 2018 BACKGROUND: Decisions to limit care, including use of a do-not-resuscitate (DNR) order, are associated with increased risk of death after intracerebral hemorrhage (ICH). Given the value that patient surrogates place on the physician's perception of prognos ... Full text Link to item Cite

Hypertension and intracerebral hemorrhage recurrence among white, black, and Hispanic individuals.

Journal Article Neurology · July 3, 2018 OBJECTIVE: To clarify whether recurrence risk for intracerebral hemorrhage (ICH) is higher among black and Hispanic individuals and whether this disparity is attributable to differences in blood pressure (BP) measurements and their variability. METHODS: We ... Full text Link to item Cite

Emerging electromagnetic technologies for brain diseases diagnostics, monitoring and therapy

Book · March 10, 2018 This timely book presents innovative technologies for use in the diagnosis, monitoring, and treatment of brain disease. These technologies offer exciting possibilities in the medical field owing to their low-cost, portability and safety. The authors addres ... Full text Cite

Systemic inflammatory response syndrome, infection, and outcome in intracerebral hemorrhage.

Journal Article Neurol Neuroimmunol Neuroinflamm · March 2018 OBJECTIVE: Systemic inflammatory response syndrome (SIRS) may be related to poor outcomes after intracerebral hemorrhage (ICH). METHODS: The Ethnic/Racial Variations of Intracerebral Hemorrhage study is an observational study of ICH in whites, blacks, and ... Full text Link to item Cite

Association of IL6ST (gp130) Polymorphism with Functional Outcome Following Spontaneous Intracerebral Hemorrhage.

Journal Article J Stroke Cerebrovasc Dis · January 2018 BACKGROUND AND PURPOSE: Genes associated with the inflammatory response and cytostructural integrity may influence recovery following a brain injury. To examine this in the setting of spontaneous intracerebral hemorrhage (ICH), selected single nucleotide p ... Full text Link to item Cite

Comparison of Genetic and Self-Identified Ancestry in Modeling Intracerebral Hemorrhage Risk.

Journal Article Front Neurol · 2018 Background: We sought to determine whether a small pool of ancestry-informative DNA markers (AIMs) improves modeling of intracerebral hemorrhage (ICH) risk in heterogeneous populations, compared with self-identified race/ethnicity (SIRE) alone. Methods: We ... Full text Link to item Cite

Brain Microdialysis

Chapter · January 1, 2018 Cerebral microdialysis is an emerging monitoring technique that is currently being studied for treatment of neurologic diseases such as subarachnoid hemorrhage and traumatic brain injury. Its ability to sample the molecules of the extracellular environment ... Full text Cite

Factors Considered by Clinicians when Prognosticating Intracerebral Hemorrhage Outcomes.

Journal Article Neurocrit Care · December 2017 BACKGROUND: The early subjective clinical judgment of clinicians outperforms formal prognostic scales for accurate determination of outcome after intracerebral hemorrhage (ICH), with the judgment of physicians and nurses having equivalent accuracy. This st ... Full text Link to item Cite

Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage.

Journal Article Neurology · September 5, 2017 OBJECTIVE: Because age affects hormonal production differently in women compared with men, we sought to define sex and age interactions across a multiracial/ethnic population after intracerebral hemorrhage (ICH) to uncover evidence that loss of gonadal hor ... Full text Link to item Cite

Gonadal hormone regulation as therapeutic strategy after acute intracerebral hemorrhage

Journal Article Proceedings of Singapore Healthcare · September 1, 2017 Full text Cite

Aggressiveness of care following intracerebral hemorrhage in women and men.

Journal Article Neurology · July 25, 2017 OBJECTIVE: To compare comorbidities and use of surgery and palliative care between men and women with intracerebral hemorrhage (ICH). METHODS: The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a prospective, multicenter, case-contro ... Full text Link to item Cite

Early predictors of rapidly evolving multiple sclerosis: A case report.

Journal Article J Neuroimmunol · June 15, 2017 UNLABELLED: Objective The aim of this case report is to highlight some important features of rapidly evolving Multiple Sclerosis. BACKGROUND: In a small proportion of patients, Multiple Sclerosis (MS) can present as a fulminant disease characterised by sev ... Full text Link to item Cite

Female gonadal hormone effects on microglial activation and functional outcomes in a mouse model of moderate traumatic brain injury.

Journal Article World J Crit Care Med · May 4, 2017 AIM: To address the hypothesis that young, gonad-intact female mice have improved long-term recovery associated with decreased neuroinflammation compared to male mice. METHODS: Eight to ten week-old male, female, and ovariectomized (OVX) mice underwent clo ... Full text Open Access Link to item Cite

Sex and Age Interactions and Differences in Outcomes After Intracerebral Hemorrhage.

Journal Article J Womens Health (Larchmt) · April 2017 Featured Publication BACKGROUND: Compared to ischemic stroke, sex differences in response to intracerebral hemorrhage (ICH) are largely unexplored, and their potential interactions with patient age have not been examined. This study hypothesized that risk for poor outcome is g ... Full text Link to item Cite

Flow Arrest in Cerebrovascular Surgery

Chapter · March 28, 2017 Certain neurovascular lesions like complex aneurysms are difficult to treat using conventional neurosurgical techniques due to their size, vascular connections, morphology, or inaccessible location. In these cases, the ability to stop or reduce blood flow ... Full text Cite

Analgesia and Sedation Requirements in Mechanically Ventilated Trauma Patients With Acute, Preinjury Use of Cocaine and/or Amphetamines.

Journal Article Anesth Analg · March 2017 BACKGROUND: The purpose of this study was to determine whether mechanically ventilated trauma patients with a positive urine drug screen (UDS) for cocaine and/or amphetamines have different opioid analgesic and sedative requirements compared with similar p ... Full text Link to item Cite

Ischemic lesions, blood pressure dysregulation, and poor outcomes in intracerebral hemorrhage.

Journal Article Neurology · February 21, 2017 OBJECTIVE: To evaluate the associations among diffusion-weighted imaging (DWI) lesions, blood pressure (BP) dysregulation, MRI markers of small vessel disease, and poor outcome in a large, prospective study of primary intracerebral hemorrhage (ICH). METHOD ... Full text Link to item Cite

Peri-Hemorrhagic Edema and Secondary Hematoma Expansion after Intracerebral Hemorrhage: From Benchwork to Practical Aspects.

Journal Article Front Neurol · 2017 Spontaneous intracerebral hemorrhage (SICH) is the most lethal type of stroke. Half of these deaths occur within the acute phase. Frequently observed deterioration during the acute phase is often due to rebleeding or peri-hematomal expansion. The exact pat ... Full text Link to item Cite

The Effect of Propofol vs. Isoflurane Anesthesia on Postoperative Changes in Cerebrospinal Fluid Cytokine Levels: Results from a Randomized Trial.

Journal Article Front Immunol · 2017 INTRODUCTION: Aside from direct effects on neurotransmission, inhaled and intravenous anesthetics have immunomodulatory properties. In vitro and mouse model studies suggest that propofol inhibits, while isoflurane increases, neuroinflammation. If these fin ... Full text Link to item Cite

The State of Neurocritical Care Fellowship Training and Attitudes toward Accreditation and Certification: A Survey of Neurocritical Care Fellowship Program Directors.

Journal Article Front Neurol · 2017 Neurocritical care as a recognized and distinct subspecialty of critical care has grown remarkably since its inception in the 1980s. As of 2016, there were 61 fellowship training programs accredited by the United Council for Neurologic Subspecialties (UCNS ... Full text Link to item Cite

Cerebral venous sinus thrombosis

Chapter · January 1, 2017 Cerebral venous thrombosis (CVT) is an important etiology of stroke. Cerebral and dural vein thromboses are less common than other stroke subtypes and manifest with myriad neurological symptoms, making CVT a challenging diagnosis. This chapter reviews epid ... Full text Cite

Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage.

Journal Article Sci Rep · October 7, 2016 Presently, no pharmacological treatments have been demonstrated to improve long-term functional outcomes following intracerebral hemorrhage (ICH). Clinical evidence associates apolipoprotein E (apoE) genotype with ICH incidence and outcome. While apoE modi ... Full text Open Access Link to item Cite

Neuromuscular Disease in the Neurointensive Care Unit.

Journal Article Anesthesiol Clin · September 2016 Neuromuscular diseases are syndromic disorders that affect nerve, muscle, and/or neuromuscular junction. Knowledge about the management of these diseases is required for anesthesiologists, because these may frequently be encountered in the intensive care u ... Full text Link to item Cite

Racial-ethnic disparities in acute blood pressure after intracerebral hemorrhage.

Journal Article Neurology · August 23, 2016 OBJECTIVE: To assess race-ethnic differences in acute blood pressure (BP) following intracerebral hemorrhage (ICH) and the contribution to disparities in ICH outcome. METHODS: BPs in the field (emergency medical services [EMS]), emergency department (ED), ... Full text Link to item Cite

The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial.

Journal Article J Alzheimers Dis · April 15, 2016 BACKGROUND: Preclinical studies have found differential effects of isoflurane and propofol on the Alzheimer's disease (AD)-associated markers tau, phosphorylated tau (p-tau) and amyloid-β (Aβ). OBJECTIVE: We asked whether isoflurane and propofol have diffe ... Full text Open Access Link to item Cite

Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage.

Journal Article Neurology · March 8, 2016 OBJECTIVE: We tested the hypothesis that intraventricular hemorrhage (IVH) is associated with incontinence and gait disturbance among survivors of intracerebral hemorrhage (ICH) at 3-month follow-ups. METHODS: The Genetic and Environmental Risk Factors for ... Full text Open Access Link to item Cite

Clinician judgment vs formal scales for predicting intracerebral hemorrhage outcomes.

Journal Article Neurology · January 12, 2016 OBJECTIVE: To compare the performance of formal prognostic instruments vs subjective clinical judgment with regards to predicting functional outcome in patients with spontaneous intracerebral hemorrhage (ICH). METHODS: This prospective observational study ... Full text Open Access Link to item Cite

Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.

Journal Article Neurology · January 12, 2016 OBJECTIVE: For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 Genomes reference dataset to prov ... Full text Open Access Link to item Cite

Progesterone Improves Neurobehavioral Outcome in Models of Intracerebral Hemorrhage.

Conference Neuroendocrinology · 2016 In models of acute brain injury, progesterone improves recovery through several mechanisms including modulation of neuroinflammation. Secondary injury from neuroinflammation is a potential therapeutic target after intracerebral hemorrhage (ICH). For potent ... Full text Link to item Cite

Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage.

Journal Article Neuroendocrinology · 2016 BACKGROUND: Preclinical evidence suggests that progesterone improves recovery after intracerebral hemorrhage (ICH); however, gonadal hormones have sex-specific effects. Therefore, an experimental model of ICH was used to assess recovery after progesterone ... Full text Open Access Link to item Cite

Monocyte Count and 30-Day Case Fatality in Intracerebral Hemorrhage.

Journal Article Stroke · August 2015 BACKGROUND AND PURPOSE: Monocytes may contribute to secondary injury after intracerebral hemorrhage (ICH). We tested the association of absolute monocyte count with 30-day ICH case fatality in a multiethnic cohort. METHODS: Ethnic/Racial Variations of Intr ... Full text Link to item Cite

Falls After Intracerebral Hemorrhage

Conference STROKE · February 1, 2015 Link to item Cite

Anesthesia for interventional neuroradiology.

Journal Article Int Anesthesiol Clin · 2015 Full text Link to item Cite

Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage.

Journal Article Springerplus · 2015 BACKGROUND: Intraoperative intravascular volume expansion with hydroxyethyl starch-based colloids is thought to be associated with an increased risk of post-craniotomy hemorrhage. Evidence for this association is limited. Associations between resuscitation ... Full text Open Access Link to item Cite

Translational research in acute central nervous system injury: lessons learned and the future.

Journal Article JAMA Neurol · October 2014 IMPORTANCE: Research to improve outcomes from acute central nervous system (CNS) injury has progressed little, although limited examples (eg, induced hypothermia for out-of-hospital ventricular fibrillation cardiac arrest and birth asphyxia and tissue plas ... Full text Link to item Cite

Exploring the impact of augmenting sedation assessment with physiologic monitors.

Journal Article Aust Crit Care · August 2014 BACKGROUND: Pharmacological sedation is a necessary tool in the management of critically ill, mechanically ventilated patients. The intensive care unit (ICU) sedation strategy is to use the least amount of medication to meet safety and comfort goals. Titra ... Full text Link to item Cite

Intrastriatal injection of autologous blood or clostridial collagenase as murine models of intracerebral hemorrhage.

Journal Article J Vis Exp · July 3, 2014 Intracerebral hemorrhage (ICH) is a common form of cerebrovascular disease and is associated with significant morbidity and mortality. Lack of effective treatment and failure of large clinical trials aimed at hemostasis and clot removal demonstrate the nee ... Full text Open Access Link to item Cite

Predictors of electrocerebral inactivity with deep hypothermia.

Journal Article J Thorac Cardiovasc Surg · March 2014 OBJECTIVE: Cooling to electrocerebral inactivity (ECI) by electroencephalography (EEG) remains the gold standard to maximize cerebral and systemic organ protection during deep hypothermic circulatory arrest (DHCA). We sought to determine predictors of ECI ... Full text Link to item Cite

pH-sensitive NMDA inhibitors improve outcome in a murine model of SAH.

Journal Article Neurocrit Care · February 2014 BACKGROUND: Despite intensive research, neurological morbidity from delayed cerebral ischemia remains common after aneurysmal subarachnoid hemorrhage (SAH). In the current study, we evaluate the neuroprotective effects of a pH-dependent GluN2B subunit-sele ... Full text Link to item Cite

Insurance status and outcome after intracerebral hemorrhage: findings from Get With The Guidelines-stroke.

Journal Article J Stroke Cerebrovasc Dis · February 2014 BACKGROUND: [corrected] Few studies have examined associations among insurance status, treatment, and outcomes in patients hospitalized for intracerebral hemorrhage (ICH). METHODS: Through retrospective analyses of the Get With The Guidelines (GWTG)-Stroke ... Full text Link to item Cite

Predictors of extraventricular drain-associated bacterial ventriculitis.

Journal Article J Crit Care · February 2014 PURPOSE: Bacterial ventriculitis (BV) may develop in patients requiring external ventricular drains (EVDs). The purpose of this study was to determine predictors of EVD-associated BV onset. MATERIALS AND METHODS: A retrospective review of Duke University H ... Full text Link to item Cite

A novel application for bolus remifentanil: blunting the hemodynamic response to Mayfield skull clamp placement.

Journal Article Curr Med Res Opin · February 2014 OBJECTIVE: Neurosurgery often requires skull immobilization with a Mayfield clamp, which often causes brief intense nociceptive stimulation, hypertension and tachycardia. Blunting this response may help prevent increased intracranial pressure, cerebral ane ... Full text Link to item Cite

Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia.

Journal Article PLoS One · 2014 Female sex is associated with improved outcome in experimental brain injury models, such as traumatic brain injury, ischemic stroke, and intracerebral hemorrhage. This implies female gonadal steroids may be neuroprotective. A mechanism for this may involve ... Full text Open Access Link to item Cite

Survey of anesthesiologists practicing in American neurointensive care units as neurointensivists.

Journal Article J Neurosurg Anesthesiol · January 2014 BACKGROUND: A group of anesthesiologists practice as intensivists in neurointensive care units (NeuroICU). The current nature and implications of the role of anesthesiology-based neurointensivist remain unclear. The purpose of this survey was to assess tod ... Full text Link to item Cite

Effect of 6% hydroxyethyl starch 130/0.4 in 0.9% sodium chloride (Voluven®) on complications after subarachnoid hemorrhage: a retrospective analysis.

Journal Article Springerplus · December 2013 BACKGROUND: 6% Hydroxyethyl Starch 130/0.4 in 0.9% Sodium Chloride (Voluven®; 6% HES 130/0.4) is a colloid often used for fluid resuscitation in patients with subarachnoid hemorrhage (SAH), despite a lack of safety data for this use. The purpose of our stu ... Full text Open Access Link to item Cite

Predictors of late neurological deterioration after spontaneous intracerebral hemorrhage.

Journal Article Neurocrit Care · December 2013 BACKGROUND: Although intracerebral hemorrhage (ICH) is a common form of cerebrovascular disease, little is known about factors leading to neurological deterioration occurring beyond 48 h after hematoma formation. The purpose of this study was to characteri ... Full text Link to item Cite

Gender and age interact to affect early outcome after intracerebral hemorrhage

Journal Article PLoS ONE · November 27, 2013 Background: Intracerebral hemorrhage (ICH) is a common and devastating form of cerebrovascular disease. In ICH, gender differences in outcomes remain relatively understudied but have been examined in other neurological emergencies. Further, a potential eff ... Full text Cite

The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study protocol.

Journal Article Stroke · October 2013 BACKGROUND AND PURPOSE: Epidemiological studies of intracerebral hemorrhage (ICH) have consistently demonstrated variation in incidence, location, age at presentation, and outcomes among non-Hispanic white, black, and Hispanic populations. We report here t ... Full text Link to item Cite

Comparison of postoperative nausea between benign and malignant brain tumor patients undergoing awake craniotomy: a retrospective analysis.

Journal Article Curr Med Res Opin · September 2013 BACKGROUND: Benign and malignant brain tumors have different histopathological characteristics, including different degrees of tissue infiltration and inflammatory response. The aim of this retrospective study was to compare the incidence of postoperative ... Full text Link to item Cite

Does midline shift predict postoperative nausea in brain tumor patients undergoing awake craniotomy? A retrospective analysis.

Journal Article Curr Med Res Opin · September 2013 BACKGROUND: The presence of midline shift on neuroradiologic studies in brain tumor patients represents mass effect from the tumor and surrounding edema. We hypothesized that baseline cerebral edema as measured by midline shift would increase postoperative ... Full text Link to item Cite

Tumor necrosis factor α antagonism improves neurological recovery in murine intracerebral hemorrhage.

Journal Article J Neuroinflammation · August 20, 2013 BACKGROUND: Intracerebral hemorrhage (ICH) is a devastating stroke subtype characterized by a prominent neuroinflammatory response. Antagonism of pro-inflammatory cytokines by specific antibodies represents a compelling therapeutic strategy to improve neur ... Full text Open Access Link to item Cite

Effect of surgical clipping versus endovascular coiling on recovery from oculomotor nerve palsy in patients with posterior communicating artery aneurysms: A retrospective comparative study and meta-analysis.

Journal Article Asian J Neurosurg · July 2013 BACKGROUND: Oculomotor nerve palsy (OMNP) is a well-recognized complication of posterior communicating artery (PCOM) aneurysms. Only a few comparative studies have assessed the effect of clipping versus coiling on recovery from OMNP in PCOM aneurysms. A re ... Full text Link to item Cite

Intracerebral Hemorrhage

Journal Article · March 31, 2013 Full text Cite

ApolipoproteinE mimetic peptides improve outcome after focal ischemia.

Journal Article Exp Neurol · March 2013 Featured Publication Growing clinical evidence implicates isoform-specific effects of apolipoprotein E (apoE) in reducing neuroinflammation and mediating adaptive responses following ischemic and traumatic brain injury. However, the intact apoE holoprotein does not cross the b ... Full text Link to item Cite

Gender and age interact to affect early outcome after intracerebral hemorrhage.

Journal Article PLoS One · 2013 BACKGROUND: Intracerebral hemorrhage (ICH) is a common and devastating form of cerebrovascular disease. In ICH, gender differences in outcomes remain relatively understudied but have been examined in other neurological emergencies. Further, a potential eff ... Full text Open Access Link to item Cite

Interrater reliability of the bedside shivering assessment scale.

Journal Article Am J Crit Care · January 2013 BACKGROUND: Since its early development, the Bedside Shivering Assessment Scale (BSAS) has had only initial psychometric testing. Before this instrument is incorporated into routine practice, its interrater reliability should be explored in a diverse group ... Full text Link to item Cite

Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.

Journal Article Anesthesiology · December 2012 Featured Publication BACKGROUND: Xenon has been proven to be neuroprotective in experimental brain injury. The authors hypothesized that xenon would improve outcome from focal cerebral ischemia with a delayed treatment onset and prolonged recovery interval. METHODS: Rats were ... Full text Open Access Link to item Cite

A pilot study of cerebral and haemodynamic physiological changes during sedation with dexmedetomidine or propofol in patients with acute brain injury.

Journal Article Anaesth Intensive Care · November 2012 Sedation for the mechanically-ventilated, brain-injured patient remains challenging. The purpose of this pilot study was to compare the cerebral physiologic effects of sedation with propofol versus dexmedetomidine in mechanically-ventilated, brain-injured ... Full text Link to item Cite

Correlation of leukocytosis with early neurological deterioration following supratentorial intracerebral hemorrhage.

Journal Article J Clin Neurosci · August 2012 Featured Publication Intracerebral hemorrhage (ICH) is a devastating and common admitting diagnosis to intensive care units in the USA. Despite advances in critical care, patients with ICH often experience early neurological deterioration (END) in the first 72 hours after admi ... Full text Link to item Cite

Guilty by association?*.

Journal Article Crit Care Med · July 2012 Full text Link to item Cite

TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice.

Journal Article Anesthesiology · June 2012 Featured Publication BACKGROUND: Microglial inhibition may reduce secondary tissue injury and improve functional outcome following acute brain injury. Utilizing clinically relevant murine models of traumatic brain injury and intracerebral hemorrhage, neuroinflammatory response ... Full text Link to item Cite

Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: a translational approach.

Journal Article J Neurotrauma · May 1, 2012 Featured Publication Traumatic brain injury (TBI) and intracerebral hemorrhage (ICH) are leading causes of neurological mortality and disability in the U.S. However, therapeutic options are limited and clinical management remains largely supportive. HMG-CoA reductase inhibitor ... Full text Link to item Cite

The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage.

Journal Article Neurocrit Care · April 2012 Featured Publication BACKGROUND: Apolipoprotein E has previously been demonstrated to modulate acute brain injury responses, and administration of COG1410, an apoE-mimetic peptide derived from the receptor-binding region of apoE, improves outcome in preclinical models of acute ... Full text Link to item Cite

Interaction between sex and apolipoprotein e genetic background in a murine model of intracerebral hemorrhage.

Journal Article Transl Stroke Res · March 2012 Emerging evidence suggests sex and apolipoprotein E (APOE) genotype separately modify outcomes after intracerebral hemorrhage (ICH). We test the hypothesis that an interaction exists between sex and APOE polymorphism in modifying outcomes after ICH and is ... Full text Link to item Cite

Corrigendum

Journal Article Nursing in Critical Care · January 2012 Full text Cite

Continuous and intermittent CSF diversion after subarachnoid hemorrhage: a pilot study.

Journal Article Neurocrit Care · February 2011 BACKGROUND: We examine two accepted methods of managing cerebrospinal fluid (CSF) drainage in patients following subarachnoid hemorrhage (SAH). The first is intermittent CSF drainage when intracranial pressure (ICP) reaches a pre-defined threshold (monitor ... Full text Link to item Cite

Preface

Chapter · 2011 Cite

An observational pilot study of CSF diversion in subarachnoid haemorrhage.

Journal Article Nurs Crit Care · 2011 BACKGROUND: A primary focus of hospital treatment following admission for subarachnoid haemorrhage (SAH) is a prevention of cerebral artery vasospasm, which may result in ischaemic stroke. Intraventricular catheter (IVC) insertion to facilitate cerebral sp ... Full text Link to item Cite

Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice.

Journal Article J Neurotrauma · January 2010 Featured Publication There is emerging evidence to suggest that brain natriuretic peptide (BNP) is elevated after acute brain injury, and that it may play an adaptive role in recovery through augmentation of cerebral blood flow (CBF). Through a series of experiments, we tested ... Full text Open Access Link to item Cite

VENTRICULOSTOMY AND CSF DRAINAGE IN SAH

Conference CRITICAL CARE MEDICINE · December 1, 2009 Link to item Cite

S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage.

Journal Article Biomarkers · September 2009 Featured Publication OBJECTIVE: To determine the predictive value of S100b and brain natriuretic peptide (BNP) in order to determine accurately and quickly a discharge prognosis after primary supratentorial intracerebral haemorrhage (ICH). METHODS: After IRB approval and infor ... Full text Link to item Cite

Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage.

Journal Article Stroke · February 2009 Featured Publication BACKGROUND AND PURPOSE: The purpose of the study was to evaluate the effect of APOE genotype and the feasibility of administering an apolipoprotein E-mimetic therapeutic to modify outcomes in a murine model of intracerebral hemorrhage. METHODS: Intracerebr ... Full text Link to item Cite

Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans.

Journal Article J Stroke Cerebrovasc Dis · 2009 Featured Publication INTRODUCTION: To address the mechanisms by which apoE polymorphism affects functional outcome after intracerebral hemorrhage in humans, we tested the hypothesis that the presence of the APOE4 allele results in amplified inflammatory responses and increased ... Full text Link to item Cite

Preclinical models of intracerebral hemorrhage: a translational perspective.

Journal Article Neurocrit Care · 2008 Featured Publication Intracerebral hemorrhage (ICH) is a devastating and relatively common disease affecting as many as 50,000 people annually in the United States alone. ICH remains associated with poor outcome, and approximately 40-50% of afflicted patients will die within 3 ... Full text Link to item Cite

Use of high frequency oscillatory ventilation (HFOV) in neurocritical care patients.

Journal Article Neurocrit Care · 2007 INTRODUCTION: Adult respiratory distress syndrome (ARDS) can be a common problem associated with the treatment of acute brain injury. High frequency oscillatory ventilation (HFOV) is a developing therapy for the treatment of ARDS in adult patients that can ... Full text Link to item Cite

Brainstem auditory evoked potential monitoring: when is change in wave V significant?

Journal Article Neurology · November 22, 2005 BACKGROUND: The probability of hearing loss during cerebellopontine angle (CPA) surgery can be reduced by using brainstem auditory evoked potential (BAEP) intraoperative monitoring (IOM). A wave V latency prolongation of 1.0 milliseconds or amplitude decre ... Full text Link to item Cite