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Neha Pagidipati CV

Associate Professor of Medicine
Medicine, Cardiology
CV

Selected Publications


Relationship between body mass index and cardiometabolic health in a multi-ethnic population: A project baseline health study.

Journal Article Am J Prev Cardiol · June 2024 OBJECTIVE: Obesity is associated with a higher risk of cardiovascular disease. Understanding the associations between comprehensive health parameters and body mass index (BMI) may lead to targeted prevention efforts. METHODS: Project Baseline Health Study ... Full text Link to item Cite

Drug development for major chronic health conditions-aligning with growing public health needs: Proceedings from a multistakeholder think tank.

Journal Article Am Heart J · April 2024 The global pharmaceutical industry portfolio is skewed towards cancer and rare diseases due to more predictable development pathways and financial incentives. In contrast, drug development for major chronic health conditions that are responsible for a larg ... Full text Link to item Cite

Longitudinal Management of Cardiovascular Risk Factors Among Postpartum Women.

Journal Article J Womens Health (Larchmt) · March 27, 2024 Background: Pregnancy-related cardiovascular (CV) conditions, including hypertensive disorders of pregnancy (HDP) and gestational diabetes (GDM), are associated with increased long-term CV risk. Methods: This retrospective cohort study defined the prevalen ... Full text Link to item Cite

Worth Their Weight? An Update on New and Emerging Pharmacologic Agents for Obesity and Their Potential Role for Persons with Cardiac Conditions.

Journal Article Curr Cardiol Rep · March 2024 PURPOSE OF REVIEW: Obesity is associated with cardiovascular (CV) conditions, including but not limited to atherosclerotic disease, heart failure, and atrial fibrillation. Despite this, the impact of intentional weight loss on CV outcomes for persons with ... Full text Link to item Cite

Regional variation in cause of death in patients with type 2 diabetes: Insights from EXSCEL.

Journal Article Am Heart J · February 22, 2024 AIMS: Type 2 diabetes (T2D) is a risk factor for cardiovascular and non-cardiovascular mortality. However, global distribution of cause-specific deaths in T2D is poorly understood. We characterized cause-specific deaths by geographic region among individua ... Full text Link to item Cite

Improving Guideline-Directed Medical Therapy for Patients With Heart Failure With Reduced Ejection Fraction: A Review of Implementation Strategies.

Journal Article J Card Fail · February 2024 Despite recent advances in the use of guideline-directed medical therapy (GDMT) for patients with heart failure with reduced ejection fraction (HFrEF), achievement of target GDMT use and up-titration to goal dosages continue to be modest. In recent years, ... Full text Open Access Link to item Cite

Improving medication adherence in cardiovascular disease.

Journal Article Nat Rev Cardiol · January 3, 2024 Non-adherence to medication is a global health problem with far-reaching individual-level and population-level consequences but remains unappreciated and under-addressed in the clinical setting. With increasing comorbidity and polypharmacy as well as an ag ... Full text Open Access Link to item Cite

Short-term cardiovascular events after bariatric surgery in patients with metabolic syndrome.

Journal Article Surg Obes Relat Dis · January 2024 BACKGROUND: Patients with metabolic syndrome (MetS) are at increased risk of developing cardiovascular disease along with other adverse events after bariatric surgery. OBJECTIVES: The incidence of short-term major adverse cardiovascular events (MACE) in pa ... Full text Link to item Cite

Managing Obesity in Heart Failure: A Chance to Tip the Scales?

Journal Article JACC Heart Fail · January 2024 Obesity is associated with incident heart failure (HF), independent of other cardiovascular risk factors. Despite rising rates of both obesity and incident HF, the associations remain poorly understood between: 1) obesity and HF outcomes; and 2) weight los ... Full text Link to item Cite

Safety and Efficacy of Renal Denervation in Patients Taking Antihypertensive Medications.

Journal Article J Am Coll Cardiol · November 7, 2023 BACKGROUND: Renal denervation (RDN) reduces blood pressure (BP) in patients with uncontrolled hypertension in the absence of antihypertensive medications. OBJECTIVES: This trial assessed the safety and efficacy of RDN in the presence of antihypertensive me ... Full text Link to item Cite

Should We "RESPECT EPA" More Now? EPA and DHA for Cardiovascular Risk Reduction.

Journal Article Curr Cardiol Rep · November 2023 PURPOSE OF REVIEW: There has been much debate surrounding the use of omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for cardiovascular (CV) risk reduction. RECENT FINDINGS: Recent trials of EPA and DHA have offered conflic ... Full text Link to item Cite

Prognostic value of CT-derived coronary artery disease characteristics varies by ASCVD risk: insights from the PROMISE trial.

Journal Article Eur Radiol · July 2023 OBJECTIVES: To compare the prognostic value of individual CT-derived coronary artery disease (CAD) characteristics across categories of clinical cardiovascular risk. METHODS: The central core laboratory assessed coronary artery calcium (CAC), obstructive C ... Full text Link to item Cite

Branched-Chain Amino Acids in Computed Tomography-Defined Adipose Depots and Coronary Artery Disease: A PROMISE Trial Biomarker Substudy.

Journal Article J Am Heart Assoc · June 6, 2023 Background The interplay between branched-chain amino acid (BCAA) metabolism, an important pathway in adiposity and cardiometabolic disease, and visceral adipose depots such as hepatic steatosis (HS) and epicardial adipose tissue is unknown. We leveraged t ... Full text Link to item Cite

Contemporary patterns of lipoprotein(a) testing and associated clinical care and outcomes.

Conference Am J Prev Cardiol · June 2023 OBJECTIVE: Elevated lipoprotein(a) [Lp(a)] is associated with atherosclerotic cardiovascular disease, yet little is known about Lp(a) testing patterns in real-world practice. The objective of this analysis was to determine how Lp(a) testing is used in clin ... Full text Link to item Cite

Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy.

Journal Article Circ Genom Precis Med · June 2023 BACKGROUND: Epigenetic clocks estimate chronologic age using methylation levels at specific loci. We tested the hypothesis that accelerated epigenetic aging is associated with abnormal values in a range of clinical, imaging, and laboratory characteristics. ... Full text Link to item Cite

Evaluation of weight change and cardiometabolic risk factors in a real-world population of US adults with overweight or obesity.

Journal Article Prev Med · May 2023 Whether individuals in real-world settings are able to lose weight and improve cardiometabolic risk factors over time is unclear. We aimed to determine the management of and degree of body weight change over 2 years among individuals with overweight or obe ... Full text Link to item Cite

Coordinated Care to Optimize Cardiovascular Preventive Therapies in Type 2 Diabetes: A Randomized Clinical Trial.

Journal Article JAMA · April 18, 2023 IMPORTANCE: Evidence-based therapies to reduce atherosclerotic cardiovascular disease risk in adults with type 2 diabetes are underused in clinical practice. OBJECTIVE: To assess the effect of a coordinated, multifaceted intervention of assessment, educati ... Full text Link to item Cite

Lipid-lowering treatment among older patients with atherosclerotic cardiovascular disease.

Journal Article J Am Geriatr Soc · April 2023 BACKGROUND: The contemporary uptake of lipid-lowering therapies (LLT), including more intensive treatment with high-intensity statins and non-statin LLT, among U.S. older adults (≥75 years old) with ASCVD is unknown. METHODS: In this multicenter retrospect ... Full text Link to item Cite

Relationship between body mass index and cardiometabolic health in a multi-ethnic population: A project baseline health study.

Journal Article Am J Prev Cardiol · June 2024 OBJECTIVE: Obesity is associated with a higher risk of cardiovascular disease. Understanding the associations between comprehensive health parameters and body mass index (BMI) may lead to targeted prevention efforts. METHODS: Project Baseline Health Study ... Full text Link to item Cite

Drug development for major chronic health conditions-aligning with growing public health needs: Proceedings from a multistakeholder think tank.

Journal Article Am Heart J · April 2024 The global pharmaceutical industry portfolio is skewed towards cancer and rare diseases due to more predictable development pathways and financial incentives. In contrast, drug development for major chronic health conditions that are responsible for a larg ... Full text Link to item Cite

Longitudinal Management of Cardiovascular Risk Factors Among Postpartum Women.

Journal Article J Womens Health (Larchmt) · March 27, 2024 Background: Pregnancy-related cardiovascular (CV) conditions, including hypertensive disorders of pregnancy (HDP) and gestational diabetes (GDM), are associated with increased long-term CV risk. Methods: This retrospective cohort study defined the prevalen ... Full text Link to item Cite

Worth Their Weight? An Update on New and Emerging Pharmacologic Agents for Obesity and Their Potential Role for Persons with Cardiac Conditions.

Journal Article Curr Cardiol Rep · March 2024 PURPOSE OF REVIEW: Obesity is associated with cardiovascular (CV) conditions, including but not limited to atherosclerotic disease, heart failure, and atrial fibrillation. Despite this, the impact of intentional weight loss on CV outcomes for persons with ... Full text Link to item Cite

Regional variation in cause of death in patients with type 2 diabetes: Insights from EXSCEL.

Journal Article Am Heart J · February 22, 2024 AIMS: Type 2 diabetes (T2D) is a risk factor for cardiovascular and non-cardiovascular mortality. However, global distribution of cause-specific deaths in T2D is poorly understood. We characterized cause-specific deaths by geographic region among individua ... Full text Link to item Cite

Improving Guideline-Directed Medical Therapy for Patients With Heart Failure With Reduced Ejection Fraction: A Review of Implementation Strategies.

Journal Article J Card Fail · February 2024 Despite recent advances in the use of guideline-directed medical therapy (GDMT) for patients with heart failure with reduced ejection fraction (HFrEF), achievement of target GDMT use and up-titration to goal dosages continue to be modest. In recent years, ... Full text Open Access Link to item Cite

Improving medication adherence in cardiovascular disease.

Journal Article Nat Rev Cardiol · January 3, 2024 Non-adherence to medication is a global health problem with far-reaching individual-level and population-level consequences but remains unappreciated and under-addressed in the clinical setting. With increasing comorbidity and polypharmacy as well as an ag ... Full text Open Access Link to item Cite

Short-term cardiovascular events after bariatric surgery in patients with metabolic syndrome.

Journal Article Surg Obes Relat Dis · January 2024 BACKGROUND: Patients with metabolic syndrome (MetS) are at increased risk of developing cardiovascular disease along with other adverse events after bariatric surgery. OBJECTIVES: The incidence of short-term major adverse cardiovascular events (MACE) in pa ... Full text Link to item Cite

Managing Obesity in Heart Failure: A Chance to Tip the Scales?

Journal Article JACC Heart Fail · January 2024 Obesity is associated with incident heart failure (HF), independent of other cardiovascular risk factors. Despite rising rates of both obesity and incident HF, the associations remain poorly understood between: 1) obesity and HF outcomes; and 2) weight los ... Full text Link to item Cite

Safety and Efficacy of Renal Denervation in Patients Taking Antihypertensive Medications.

Journal Article J Am Coll Cardiol · November 7, 2023 BACKGROUND: Renal denervation (RDN) reduces blood pressure (BP) in patients with uncontrolled hypertension in the absence of antihypertensive medications. OBJECTIVES: This trial assessed the safety and efficacy of RDN in the presence of antihypertensive me ... Full text Link to item Cite

Should We "RESPECT EPA" More Now? EPA and DHA for Cardiovascular Risk Reduction.

Journal Article Curr Cardiol Rep · November 2023 PURPOSE OF REVIEW: There has been much debate surrounding the use of omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for cardiovascular (CV) risk reduction. RECENT FINDINGS: Recent trials of EPA and DHA have offered conflic ... Full text Link to item Cite

Prognostic value of CT-derived coronary artery disease characteristics varies by ASCVD risk: insights from the PROMISE trial.

Journal Article Eur Radiol · July 2023 OBJECTIVES: To compare the prognostic value of individual CT-derived coronary artery disease (CAD) characteristics across categories of clinical cardiovascular risk. METHODS: The central core laboratory assessed coronary artery calcium (CAC), obstructive C ... Full text Link to item Cite

Branched-Chain Amino Acids in Computed Tomography-Defined Adipose Depots and Coronary Artery Disease: A PROMISE Trial Biomarker Substudy.

Journal Article J Am Heart Assoc · June 6, 2023 Background The interplay between branched-chain amino acid (BCAA) metabolism, an important pathway in adiposity and cardiometabolic disease, and visceral adipose depots such as hepatic steatosis (HS) and epicardial adipose tissue is unknown. We leveraged t ... Full text Link to item Cite

Contemporary patterns of lipoprotein(a) testing and associated clinical care and outcomes.

Conference Am J Prev Cardiol · June 2023 OBJECTIVE: Elevated lipoprotein(a) [Lp(a)] is associated with atherosclerotic cardiovascular disease, yet little is known about Lp(a) testing patterns in real-world practice. The objective of this analysis was to determine how Lp(a) testing is used in clin ... Full text Link to item Cite

Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy.

Journal Article Circ Genom Precis Med · June 2023 BACKGROUND: Epigenetic clocks estimate chronologic age using methylation levels at specific loci. We tested the hypothesis that accelerated epigenetic aging is associated with abnormal values in a range of clinical, imaging, and laboratory characteristics. ... Full text Link to item Cite

Evaluation of weight change and cardiometabolic risk factors in a real-world population of US adults with overweight or obesity.

Journal Article Prev Med · May 2023 Whether individuals in real-world settings are able to lose weight and improve cardiometabolic risk factors over time is unclear. We aimed to determine the management of and degree of body weight change over 2 years among individuals with overweight or obe ... Full text Link to item Cite

Coordinated Care to Optimize Cardiovascular Preventive Therapies in Type 2 Diabetes: A Randomized Clinical Trial.

Journal Article JAMA · April 18, 2023 IMPORTANCE: Evidence-based therapies to reduce atherosclerotic cardiovascular disease risk in adults with type 2 diabetes are underused in clinical practice. OBJECTIVE: To assess the effect of a coordinated, multifaceted intervention of assessment, educati ... Full text Link to item Cite

Lipid-lowering treatment among older patients with atherosclerotic cardiovascular disease.

Journal Article J Am Geriatr Soc · April 2023 BACKGROUND: The contemporary uptake of lipid-lowering therapies (LLT), including more intensive treatment with high-intensity statins and non-statin LLT, among U.S. older adults (≥75 years old) with ASCVD is unknown. METHODS: In this multicenter retrospect ... Full text Link to item Cite

Call to action: Understanding the differences in the use of SGLT-2 inhibitors and GLP-1 receptor agonists.

Journal Article American journal of preventive cardiology · March 2023 Cardiovascular disease remains one of the most prominent global health problems and has been demonstrated to disproportionally affect certain communities. Despite an increasing collective effort to improve health inequalities, a multitude of disparities co ... Full text Open Access Cite

Coordinating Cardiology clinics randomized trial of interventions to improve outcomes (COORDINATE) - Diabetes: rationale and design.

Journal Article Am Heart J · February 2023 Several medications that are proven to reduce cardiovascular events exist for individuals with type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease, however they are substantially underused in clinical practice. Clinician, patient, an ... Full text Link to item Cite

Bending the Cardiovascular Event Curve by Evaluating the Potential Impact of Achieving Low-Density Lipoprotein Cholesterol Goal Across a Large Health System Among Secondary Prevention Patients.

Journal Article Am J Cardiol · January 1, 2023 Guidelines recommend aggressive low-density lipoprotein cholesterol (LDL-C) lowering in patients with atherosclerotic cardiovascular disease (ASCVD). However, the recommended threshold of LDL-C ≤70 mg/dL is often not achieved. We used data from the Duke Un ... Full text Link to item Cite

Lipid-Lowering Therapy in Women of Childbearing Age: a Review and Stepwise Clinical Approach.

Journal Article Curr Cardiol Rep · October 2022 PURPOSE OF REVIEW: Women are less often recognized to have cardiovascular disease (CVD) risk and are underrepresented in randomized trials of lipid-lowering therapy. Here, we summarize non-pharmacologic and pharmacologic strategies for lipid-lowering in wo ... Full text Link to item Cite

Eradicating Atherosclerosis: Should We Start Statins at Younger Ages and at Lower LDL-Cs.

Journal Article Curr Cardiol Rep · October 2022 PURPOSE OF REVIEW: Given the increasing burden of cardiovascular disease, we review the literature for earlier initiation of statin therapy at younger ages and lower low-density lipoprotein cholesterol (LDL-C) levels, with the goal of preventing the develo ... Full text Link to item Cite

Sodium-Glucose Cotransporter-2 Inhibitors: Impact on Atherosclerosis and Atherosclerotic Cardiovascular Disease Events.

Journal Article Heart Fail Clin · October 2022 Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) improve the risk for heart and kidney failure. However, their effects on major atherosclerotic cardiovascular events (MACE) are less clear. Although outcomes trials of drugs for diabetes were not powered ... Full text Link to item Cite

Management of cardiovascular risk factors during pregnancy.

Journal Article Heart · August 25, 2022 Cardiovascular (CV) risk factors are rising among women of reproductive age. Obesity, hyperlipidaemia, diabetes, and hypertension are associated with adverse pregnancy outcomes and increased CV disease (CVD) risk following pregnancy. Pre-conception counsel ... Full text Link to item Cite

Multi-dimensional characterization of prediabetes in the Project Baseline Health Study.

Journal Article Cardiovasc Diabetol · July 18, 2022 BACKGROUND: We examined multi-dimensional clinical and laboratory data in participants with normoglycemia, prediabetes, and diabetes to identify characteristics of prediabetes and predictors of progression from prediabetes to diabetes or reversion to no di ... Full text Link to item Cite

Hypertensive Disorders of Pregnancy and Heart Failure Risk.

Journal Article Curr Hypertens Rep · July 2022 PURPOSE OF REVIEW: To review the data on hypertensive disorders of pregnancy (HDP) and heart failure (HF) risk. RECENT FINDINGS: Hypertensive disorders are the most common medical condition affecting women during pregnancy and are associated with future HF ... Full text Link to item Cite

Guidelines for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes: JACC Guideline Comparison.

Journal Article J Am Coll Cardiol · May 10, 2022 Cardiovascular disease is a leading cause of morbidity and mortality in individuals with type 2 diabetes mellitus. These high-risk patients benefit from aggressive risk factor management, with blood pressure and low-density lipoprotein-cholesterol treatmen ... Full text Link to item Cite

High-Intensity Statin Use Among Patients With Atherosclerosis in the U.S.

Journal Article J Am Coll Cardiol · May 10, 2022 BACKGROUND: Preventive therapy among patients with established atherosclerotic cardiovascular disease (ASCVD) is generally underused. Whether new guideline recommendations and a focus on implementation have improved the use of high-intensity statins is unk ... Full text Link to item Cite

Presenting Symptoms in Patients Undergoing Coronary Artery Disease Evaluation: Association With Noninvasive Test Results and Clinical Outcomes in the PROMISE Trial.

Journal Article Circ Cardiovasc Qual Outcomes · May 2022 BACKGROUND: Patients evaluated for coronary artery disease have a range of symptoms and underlying risk. The relationships between patient-described symptoms, clinician conclusions, and subsequent clinical management and outcomes remain incompletely descri ... Full text Link to item Cite

Alirocumab after acute coronary syndrome in patients with a history of heart failure.

Journal Article Eur Heart J · April 19, 2022 AIMS: Patients with heart failure (HF) have not been shown to benefit from statins. In a post hoc analysis, we evaluated outcomes in ODYSSEY OUTCOMES in patients with vs. without a history of HF randomized to the proprotein convertase subtilisin/kexin type ... Full text Link to item Cite

Use of Lipid-, Blood Pressure-, and Glucose-Lowering Pharmacotherapy in Patients With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease.

Journal Article JAMA Netw Open · February 1, 2022 IMPORTANCE: Based on contemporary estimates in the US, evidence-based therapies for cardiovascular risk reduction are generally underused among patients with type 2 diabetes and atherosclerotic cardiovascular disease (ASCVD). OBJECTIVE: To determine the us ... Full text Link to item Cite

Are risk factors necessary for pretest probability assessment of coronary artery disease? A patient similarity network analysis of the PROMISE trial.

Journal Article J Cardiovasc Comput Tomogr · 2022 BACKGROUND: Pretest probability (PTP) calculators utilize epidemiological-level findings to provide patient-level risk assessment of obstructive coronary artery disease (CAD). However, their limited accuracies question whether dissimilarities in risk facto ... Full text Link to item Cite

The importance of weight stabilization amongst those with overweight or obesity: Results from a large health care system.

Journal Article Prev Med Rep · December 2021 Data on patterns of weight change among adults with overweight or obesity are minimal. We aimed to examine patterns of weight change and associated hospitalizations in a large health system, and to develop a model to predict 2-year significant weight gain. ... Full text Link to item Cite

Polyvascular disease and increased risk of cardiovascular events in patients with type 2 diabetes: Insights from the EXSCEL trial.

Journal Article Atherosclerosis · December 2021 BACKGROUND AND AIMS: Polyvascular disease is an independent predictor of major adverse cardiovascular events (MACE). The relationship between the number of diseased arterial beds and MACE is unknown. How MACE risk changes in individuals with type 2 diabete ... Full text Link to item Cite

In-Hospital Initiation of Sodium-Glucose Cotransporter-2 Inhibitors for Heart Failure With Reduced Ejection Fraction.

Journal Article J Am Coll Cardiol · November 16, 2021 Sodium-glucose cotransporter-2 inhibitor therapy is well suited for initiation during the heart failure hospitalization, owing to clinical benefits that accrue rapidly within days to weeks, a strong safety and tolerability profile, minimal to no effects on ... Full text Link to item Cite

Risk Stratification With the Use of Coronary Computed Tomographic Angiography in Patients With Nonobstructive Coronary Artery Disease.

Journal Article JACC Cardiovasc Imaging · November 2021 OBJECTIVES: The purpose of this study was to develop a risk prediction model for patients with nonobstructive CAD. BACKGROUND: Among stable chest pain patients, most cardiovascular (CV) events occur in those with nonobstructive coronary artery disease (CAD ... Full text Link to item Cite

Predicting major adverse limb events in individuals with type 2 diabetes: Insights from the EXSCEL trial.

Journal Article Diabet Med · October 2021 AIMS: Although models exist to predict amputation among people with type 2 diabetes with foot ulceration or infection, we aimed to develop a prediction model for a broader range of major adverse limb events (MALE)-including gangrene, revascularization and ... Full text Link to item Cite

Should Cardiovascular Preventive Therapy Be Over-the-Counter?

Journal Article J Am Coll Cardiol · September 14, 2021 Full text Link to item Cite

Effect of once-weekly exenatide on hospitalization for acute coronary syndrome or coronary revascularization in patients with type 2 diabetes mellitus.

Journal Article Am Heart J · September 2021 Cardiovascular (CV) outcome studies of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shifted the paradigm of type 2 diabetes management given their benefits regarding a reduction in major adverse CV events. However, the relationship between GL ... Full text Link to item Cite

A Comprehensive Cardiovascular-Renal-Metabolic Risk Reduction Approach to Patients with Type 2 Diabetes Mellitus.

Journal Article Am J Med · September 2021 Despite decades of research into risk-reduction strategies, cardiovascular disease and renal disease remain leading causes of morbidity and mortality among patients with type 2 diabetes mellitus. Given the tight clustering of cardiovascular and renal disea ... Full text Link to item Cite

Lipoprotein(a) Testing Patterns in a Large Health System.

Journal Article Am J Cardiol · August 15, 2021 Lipoprotein (a) [Lp(a)] is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD). As directed therapy for Lp(a) emerges, it is important to understand patterns of Lp(a) testing in routine clinical practice. We set out to characte ... Full text Link to item Cite

Incorporating SGLT2i and GLP-1RA for Cardiovascular and Kidney Disease Risk Reduction: Call for Action to the Cardiology Community.

Journal Article Circulation · July 6, 2021 Multiple sodium glucose cotransporter-2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) have been shown to impart significant cardiovascular and kidney benefits, but are underused in clinical practice. Both SGLT-2i and GLP-1RA ... Full text Link to item Cite

Time for a Renewed Focus on the DASH-Low Sodium Diet.

Journal Article J Am Coll Cardiol · June 1, 2021 Full text Link to item Cite

The SAMSON trial: using a placebo to improve medication tolerability.

Journal Article Eur Heart J Cardiovasc Pharmacother · May 23, 2021 Full text Link to item Cite

Association of Metabolic Phenotypes With Coronary Artery Disease and Cardiovascular Events in Patients With Stable Chest Pain.

Journal Article Diabetes Care · April 2021 OBJECTIVE: Obesity and metabolic syndrome are associated with major adverse cardiovascular events (MACE). However, whether distinct metabolic phenotypes differ in risk for coronary artery disease (CAD) and MACE is unknown. We sought to determine the associ ... Full text Link to item Cite

Gaps in Evidence-Based Therapy Use in Insured Patients in the United States With Type 2 Diabetes Mellitus and Atherosclerotic Cardiovascular Disease.

Journal Article J Am Heart Assoc · January 19, 2021 Background Evidence-based therapies are generally underused for cardiovascular risk reduction; however, less is known about contemporary patients with type 2 diabetes mellitus and atherosclerotic cardiovascular disease. Methods and Results Pharmacy and med ... Full text Link to item Cite

Impact of the COVID-19 pandemic on patterns of outpatient cardiovascular care.

Journal Article Am Heart J · January 2021 BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic brought about abrupt changes in the way health care is delivered, and the impact of transitioning outpatient clinic visits to telehealth visits on processes of care and outcomes is unclear. METHO ... Full text Link to item Cite

Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.

Journal Article PLoS One · 2021 Obesity is an epidemic internationally. While weight loss interventions are efficacious, they are compounded by heterogeneity with regards to clinically relevant metabolic responses. Thus, we sought to identify metabolic biomarkers that are associated with ... Full text Link to item Cite

Risk Factor Burden and Long-Term Prognosis of Patients With Premature Coronary Artery Disease.

Journal Article J Am Heart Assoc · December 15, 2020 Background Coronary artery disease (CAD) is increasing among young adults. We aimed to describe the cardiovascular risk factors and long-term prognosis of premature CAD. Methods and Results Using the Duke Databank for Cardiovascular Disease, we evaluated 3 ... Full text Link to item Cite

Novel plasma biomarkers improve discrimination of metabolic health independent of weight.

Journal Article Sci Rep · December 7, 2020 We sought to determine if novel plasma biomarkers improve traditionally defined metabolic health (MH) in predicting risk of cardiovascular disease (CVD) events irrespective of weight. Poor MH was defined in CATHGEN biorepository participants (n > 9300), a ... Full text Link to item Cite

Association Between Triglycerides and Residual Cardiovascular Risk in Patients With Type 2 Diabetes Mellitus and Established Cardiovascular Disease (From the Bypass Angioplasty Revascularization Investigation 2 Diabetes [BARI 2D] Trial).

Journal Article Am J Cardiol · October 1, 2020 Triglyceride (TG) levels encompass several lipoproteins that have been implicated in atherogenic pathways. Whether TG levels independently associate with cardiovascular disease both overall and, in particular among patients with established coronary artery ... Full text Link to item Cite

Comparison of Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction With Versus Without Hyperuricemia or Gout.

Journal Article Am J Cardiol · July 15, 2020 Hyperuricemia and gout are common in patients with heart failure (HF) and are associated with poor outcomes. Data describing hyperuricemia and gout in patients with HF with preserved ejection fraction (HFpEF) are limited. We used data from the Duke Univers ... Full text Link to item Cite

Park Quality and Road Walkability in Greater Noida, India: A Case Study Demonstrating GIS for Assessing Barriers to Being Physically Active in Urban Areas

Journal Article International Journal of Applied Geospatial Research · July 1, 2020 In urbanizing India, walkability and outdoor physical activities are essential for a healthy lifestyle. Urban roads need to be assessed for walkability, and public parks need to be assessed as spaces for physical activities. Not many studies have looked at ... Full text Cite

Rationale and design of "Hearts & Parks": study protocol for a pragmatic randomized clinical trial of an integrated clinic-community intervention to treat pediatric obesity.

Journal Article BMC Pediatr · June 26, 2020 BACKGROUND: The prevalence of child and adolescent obesity and severe obesity continues to increase despite decades of policy and research aimed at prevention. Obesity strongly predicts cardiovascular and metabolic disease risk; both begin in childhood. Ch ... Full text Link to item Cite

Prevalence and Management of Adult Obesity in a Large U.S. Academic Health System.

Journal Article Am J Prev Med · June 2020 INTRODUCTION: Both medication and surgical interventions can be used to treat obesity, yet their use and effectiveness in routine clinical practice are not clear. This study sought to characterize the prevalence and management of patients with obesity with ... Full text Link to item Cite

Barriers to prescribing glucose-lowering therapies with cardiometabolic benefits.

Journal Article Am Heart J · June 2020 BACKGROUND: The adoption of 2 classes of new diabetes medications, glucagon-like peptide 1 receptor agonists (GLP1RA) and sodium-glucose co-transporter-2 inhibitors (SGLT2i), has been slow in the United States despite their cardiovascular benefits in addit ... Full text Link to item Cite

Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial.

Journal Article Lancet · May 2, 2020 BACKGROUND: Catheter-based renal denervation has significantly reduced blood pressure in previous studies. Following a positive pilot trial, the SPYRAL HTN-OFF MED (SPYRAL Pivotal) trial was designed to assess the efficacy of renal denervation in the absen ... Full text Link to item Cite

Sex Differences in Quality of Life and Clinical Outcomes in Patients With Advanced Heart Failure: Insights From the PAL-HF Trial.

Journal Article Circ Heart Fail · April 2020 BACKGROUND: Palliative care improves quality of life in patients with heart failure. Whether men and women with heart failure derive similar benefit from palliative care interventions remains unknown. METHODS: In a secondary analysis of the PAL-HF trial (P ... Full text Link to item Cite

Clinical and Economic Implications of Inconclusive Noninvasive Test Results in Stable Patients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial.

Journal Article Circ Cardiovasc Imaging · April 2020 BACKGROUND: Inconclusive noninvasive tests complicate the care of patients with suspected coronary artery disease, but their prevalence and impact on management, outcomes, and costs are not well described. METHODS: PROMISE (Prospective Multicenter Imaging ... Full text Link to item Cite

Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus: Lessons Learned and Future Directions.

Journal Article Circulation · March 10, 2020 Responding to concerns about the potential for increased risk of adverse cardiovascular outcomes, specifically myocardial infarction, associated with certain glucose-lowering therapies, the US Food and Drug Administration and the Committee for Medicinal Pr ... Full text Link to item Cite

Racial Differences in Elevated C-Reactive Protein Among US Older Adults.

Journal Article J Am Geriatr Soc · February 2020 OBJECTIVES: To investigate racial differences in elevated C-reactive protein (CRP) and the potential factors contributing to these differences in US older men and women. DESIGN: Nationally representative cohort study. SETTING: Health and Retirement Study, ... Full text Link to item Cite

Discordances between predicted and actual risk in obese patients with suspected cardiac ischaemia.

Journal Article Heart · February 2020 OBJECTIVES: To test the relationship between increasing severity of obesity, calculated risk and observed outcomes. METHODS: Patients with symptoms suggestive of coronary artery disease (CAD) (n=10 003) were stratified according to body mass index (BMI). W ... Full text Link to item Cite

Within-Trial Evaluation of Medical Resources, Costs, and Quality of Life Among Patients With Type 2 Diabetes Participating in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL).

Journal Article Diabetes Care · February 2020 OBJECTIVE: To compare medical resource use, costs, and health utilities for 14,752 patients with type 2 diabetes who were randomized to once-weekly exenatide (EQW) or placebo in addition to usual diabetes care in the Exenatide Study of Cardiovascular Event ... Full text Link to item Cite

Association of obesity with cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease: Insights from TECOS.

Journal Article Am Heart J · January 2020 BACKGROUND: Obesity is a risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). Whether obesity affects outcomes among those with T2D and atherosclerotic CVD (ASCVD) remains uncertain. Our objective was to investigate the relationship betw ... Full text Link to item Cite

The association between triglycerides and incident cardiovascular disease: What is "optimal"?

Journal Article J Clin Lipidol · 2020 BACKGROUND: Elevated triglycerides (TGs) are associated with increased risk of cardiovascular disease (CVD), but the best way to both measure TGs and assess TG-related risk remains unknown. OBJECTIVE: The objective of the study was to evaluate the associat ... Full text Link to item Cite

How and when informative visit processes can bias inference when using electronic health records data for clinical research.

Journal Article J Am Med Inform Assoc · December 1, 2019 OBJECTIVE: Electronic health records (EHR) data have become a central data source for clinical research. One concern for using EHR data is that the process through which individuals engage with the health system, and find themselves within EHR data, can be ... Full text Link to item Cite

International variation in characteristics and clinical outcomes of patients with type 2 diabetes and heart failure: Insights from TECOS.

Journal Article Am Heart J · December 2019 International differences in management/outcomes among patients with type 2 diabetes and heart failure (HF) are not well characterized. We sought to evaluate geographic variation in treatment and outcomes among these patients. METHODS AND RESULTS: Among 14 ... Full text Link to item Cite

Clinical Outcomes in Patients With Type 2 Diabetes Mellitus and Peripheral Artery Disease: Results From the EXSCEL Trial.

Journal Article Circ Cardiovasc Interv · December 2019 BACKGROUND: Recent trials have identified anti-diabetes mellitus agents that lower major adverse cardiovascular event (MACE) rates, although some increase rates of lower-extremity amputation (LEA). Patients with peripheral artery disease (PAD) have greater ... Full text Link to item Cite

Effect of Once-Weekly Exenatide in Patients With Type 2 Diabetes Mellitus With and Without Heart Failure and Heart Failure-Related Outcomes: Insights From the EXSCEL Trial.

Journal Article Circulation · November 12, 2019 BACKGROUND: Once-weekly exenatide (EQW) had a neutral effect on hospitalization for heart failure (HHF) in the EXSCEL study (Exenatide Study of Cardiovascular Event Lowering), with no differential treatment effect on major adverse cardiac events by baselin ... Full text Link to item Cite

Opportunities for improving use of evidence-based therapy in patients with type 2 diabetes and cardiovascular disease.

Journal Article Clin Cardiol · November 2019 Evidence-based therapy that target hyperlipidemia, hypertension, smoking cessation, and weight loss have demonstrated significant benefits in reducing cardiovascular risks and related events. Although the benefit of intensively lowering blood glucose is un ... Full text Link to item Cite

Risk of Total Events With Icosapent Ethyl: Can We Reduce It?

Journal Article Journal of the American College of Cardiology · June 2019 Full text Cite

DIFFERENCES IN ACHIEVING HBA1C GOALS AMONG PATIENTS SEEN BY ENDOCRINOLOGISTS AND PRIMARY CARE PROVIDERS.

Journal Article Endocr Pract · May 2019 Objective: This study evaluated whether there is a difference in the proportion of patients with type 2 diabetes who achieve a hemoglobin A1c (HbA1c) <7% within one year following treatment by an endocrinologist or primary care physician (PCP). Methods: We ... Full text Link to item Cite

An outcome model approach to transporting a randomized controlled trial results to a target population.

Journal Article J Am Med Inform Assoc · May 1, 2019 OBJECTIVE: Participants enrolled into randomized controlled trials (RCTs) often do not reflect real-world populations. Previous research in how best to transport RCT results to target populations has focused on weighting RCT data to look like the target da ... Full text Link to item Cite

Stress Testing Versus CT Angiography in Patients With Diabetes and Suspected Coronary Artery Disease.

Journal Article J Am Coll Cardiol · March 5, 2019 BACKGROUND: The optimal noninvasive test (NIT) for patients with diabetes and stable symptoms of coronary artery disease (CAD) is unknown. OBJECTIVES: The purpose of this study was to assess whether a diagnostic strategy based on coronary computed tomograp ... Full text Link to item Cite

Clinical Updates in Women's Health Care Summary: Evaluation and Management of Lipid Disorders: Primary and Preventive Care Review.

Journal Article Obstet Gynecol · March 2019 Cardiovascular disease (CVD) remains the leading cause of mortality for women, and only a small percentage of women have optimally managed risk factors. One of the strongest risk factors for CVD is an increased lipid level. Many women seek primary care fro ... Full text Link to item Cite

Sex differences in management and outcomes of patients with stable symptoms suggestive of coronary artery disease: Insights from the PROMISE trial.

Journal Article Am Heart J · February 2019 BACKGROUND: Although sex differences exist in the management of acute coronary syndromes, less is known about the management and outcomes of women and men with suspected coronary artery disease being evaluated with noninvasive testing (NIT). METHODS: We in ... Full text Link to item Cite

Effects of obesity on noninvasive test results in patients with suspected cardiac ischemia: Insights from the PROMISE trial.

Journal Article J Cardiovasc Comput Tomogr · 2019 BACKGROUND: Obesity is a risk factor for coronary artery disease (CAD), but adiposity may mimic symptoms of CAD and reduce the accuracy of diagnostic testing. METHODS: Patients from the PROMISE trial (n = 8889) were classified according to body mass index ... Full text Link to item Cite

Atherosclerotic cardiovascular disease and heart failure: Determinants of risk and outcomes in patients with diabetes.

Journal Article Prog Cardiovasc Dis · 2019 Cardiovascular disease (CVD) is the most common cause of morbidity and mortality for patients with diabetes mellitus (DM). Although the burden of atherosclerotic CVD (ASCVD) is well documented, heart failure (HF) has been an under-appreciated CVD complicat ... Full text Link to item Cite

Sex differences in long-term outcomes of patients across the spectrum of coronary artery disease.

Journal Article Am Heart J · December 2018 BACKGROUND: Patients with nonobstructive coronary artery disease (CAD) have worse outcomes compared with those without CAD; however, few studies have compared the intermediate- and long-term impact of CAD severity as a function of patient sex. METHODS: We ... Full text Link to item Cite

Effect of Once-Weekly Exenatide on Clinical Outcomes According to Baseline Risk in Patients With Type 2 Diabetes Mellitus: Insights From the EXSCEL Trial.

Journal Article J Am Heart Assoc · October 2, 2018 Background In the EXSCEL (Exenatide Study of Cardiovascular Event Lowering), exenatide once-weekly resulted in a nonsignificant reduction in major adverse cardiovascular events ( MACEs ) and a nominal 14% reduction in all-cause mortality in 14 752 patients ... Full text Open Access Link to item Cite

High-sensitivity C-reactive protein elevation in patients with prior myocardial infarction in the United States.

Journal Article Am Heart J · October 2018 IMPORTANCE: The extent to which levels of high-sensitivity C-reactive protein (hs-CRP), a known marker of increased cardiovascular risk, are elevated and are associated with standard cardiovascular risk factors in patients with a history of myocardial infa ... Full text Link to item Cite

Value of Neighborhood Socioeconomic Status in Predicting Risk of Outcomes in Studies That Use Electronic Health Record Data.

Journal Article JAMA Netw Open · September 7, 2018 IMPORTANCE: Data from electronic health records (EHRs) are increasingly used for risk prediction. However, EHRs do not reliably collect sociodemographic and neighborhood information, which has been shown to be associated with health. The added contribution ... Full text Link to item Cite

Association of Gout With Long-Term Cardiovascular Outcomes Among Patients With Obstructive Coronary Artery Disease.

Journal Article J Am Heart Assoc · August 21, 2018 Background Epidemiological studies demonstrating a relationship between gout and cardiovascular disease are older and predate modern cardiovascular preventive therapy. We assessed the contemporary association between gout and cardiovascular disease in pati ... Full text Link to item Cite

Cardiovascular Diseases in India Compared With the United States.

Journal Article J Am Coll Cardiol · July 3, 2018 This review describes trends in the burden of cardiovascular diseases (CVDs) and risk factors in India compared with the United States; provides potential explanations for these differences; and describes strategies to improve cardiovascular health behavio ... Full text Link to item Cite

Long-Term Mortality of Older Patients With Acute Myocardial Infarction Treated in US Clinical Practice.

Journal Article J Am Heart Assoc · June 30, 2018 BACKGROUND: There is limited information about the long-term survival of older patients after myocardial infarction (MI). METHODS AND RESULTS: CRUSADE (Can rapid risk stratification of unstable angina patients suppress adverse outcomes with early implement ... Full text Link to item Cite

Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis.

Journal Article Lancet Diabetes Endocrinol · February 2018 BACKGROUND: Glucagon-like peptide-1 (GLP-1) receptor agonists are effective glucose-lowering drugs. Findings from cardiovascular outcome trials showed cardiovascular safety of GLP-1 receptor agonists, but results for cardiovascular efficacy were varied. We ... Full text Link to item Cite

Impact of Diabetes Mellitus on the Evaluation of Stable Chest Pain Patients: Insights From the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) Trial.

Journal Article J Am Heart Assoc · October 31, 2017 BACKGROUND: The impact of diabetes mellitus on the clinical presentation and noninvasive test (NIT) results among stable outpatients presenting with symptoms suggestive of coronary artery disease (CAD) has not been well described. METHODS AND RESULTS: The ... Full text Link to item Cite

Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.

Journal Article N Engl J Med · September 28, 2017 BACKGROUND: The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. METHODS: We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, ... Full text Open Access Link to item Cite

Secondary Prevention of Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus: International Insights From the TECOS Trial (Trial Evaluating Cardiovascular Outcomes With Sitagliptin).

Journal Article Circulation · September 26, 2017 BACKGROUND: Intensive risk factor modification significantly improves outcomes for patients with diabetes mellitus and cardiovascular disease. However, the degree to which secondary prevention treatment goals are achieved in international clinical practice ... Full text Link to item Cite

Use of Prescription Smoking Cessation Medications After Myocardial Infarction Among Older Patients in Community Practice.

Journal Article JAMA Cardiol · September 1, 2017 This population-based study uses the Acute Coronary Treatment and Intervention Outcomes Network Registry to evaluate the prevalence of smoking cessation medication use among patients following myocardial infarction. ... Full text Link to item Cite

Baseline characteristics of patients enrolled in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL).

Journal Article Am Heart J · May 2017 BACKGROUND: EXSCEL is a randomized, double-blind, placebo-controlled trial examining the effect of exenatide once-weekly (EQW) versus placebo on time to the primary composite outcome (cardiovascular death, nonfatal myocardial infarction or nonfatal stroke) ... Full text Link to item Cite

An examination of the relationship between serum uric acid level, a clinical history of gout, and cardiovascular outcomes among patients with acute coronary syndrome.

Journal Article Am Heart J · May 2017 BACKGROUND: Studies have suggested a relationship between higher baseline serum uric acid (sUA) levels and an elevated risk of subsequent ischemic cardiovascular outcomes among acute coronary syndrome (ACS) patients; this relationship may be modified by a ... Full text Link to item Cite

Comparison of Recommended Eligibility for Primary Prevention Statin Therapy Based on the US Preventive Services Task Force Recommendations vs the ACC/AHA Guidelines.

Journal Article JAMA · April 18, 2017 IMPORTANCE: There are important differences among guideline recommendations for using statin therapy in primary prevention. New recommendations from the US Preventive Services Task Force (USPSTF) emphasize therapy based on the presence of 1 or more cardiov ... Full text Link to item Cite

Acute coronary syndromes in women and men.

Journal Article Nat Rev Cardiol · August 2016 Evidence of sex-related disparities in the care and outcomes of patients with acute coronary syndrome (ACS) emerged >30 years ago, and yet the mechanisms behind these sex-specific differences remain unclear. In this Review, we discuss the current literatur ... Full text Link to item Cite

Sex Differences in Functional and CT Angiography Testing in Patients With Suspected Coronary Artery Disease.

Journal Article J Am Coll Cardiol · June 7, 2016 BACKGROUND: Although risk stratification is an important goal of cardiac noninvasive tests (NITs), few contemporary data exist on the prognostic value of different NITs according to patient sex. OBJECTIVES: The goal of this study was to compare the results ... Full text Link to item Cite

The Enigma of Glucose and Lipid Metabolism.

Journal Article JAMA Cardiol · May 1, 2016 Full text Link to item Cite

Sex Differences in Demographics, Risk Factors, Presentation, and Noninvasive Testing in Stable Outpatients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial.

Journal Article JACC Cardiovasc Imaging · April 2016 OBJECTIVES: The aim of this study was to determine whether presentation, risk assessment, testing choices, and results differ by sex in stable symptomatic outpatients with suspected coronary artery disease (CAD). BACKGROUND: Although established CAD presen ... Full text Link to item Cite

Association between gender, process of care measures, and outcomes in ACS in India: results from the detection and management of coronary heart disease (DEMAT) registry.

Journal Article PLoS One · 2013 BACKGROUND: Studies from high-income countries have shown that women receive less aggressive diagnostics and treatment than men in acute coronary syndromes (ACS), though their short-term mortality does not appear to differ from men. Data on gender differen ... Full text Link to item Cite

Scaling up chronic disease prevention interventions in lower- and middle-income countries.

Book · 2013 Chronic diseases are increasingly becoming a health burden in lower- and middle-income countries, putting pressure on public health efforts to scale up interventions. This article reviews current efforts in interventions on a population and individual leve ... Full text Link to item Cite

Global cardiovascular therapy

Chapter · January 1, 2012 Full text Cite