Scholars@Duke
Nicholas Turner

Nicholas Turner

Assistant Professor of Medicine
Medicine, Infectious Diseases

Selected Publications

Long-term trends in the incidence of hospital-acquired carbapenem-resistant Enterobacterales and antimicrobial utilization in a network of community hospitals in the Southeastern United States from 2013 to 2023.

Journal Article Infect Control Hosp Epidemiol · December 3, 2024 BACKGROUND: Carbapenem-resistant Enterobacterales (CRE) are an urgent threat to healthcare, but the epidemiology of these antimicrobial-resistant organisms may be evolving in some settings since the COVID-19 pandemic. An updated analysis of hospital-acquir ... Full text Link to item Cite

Beyond Infection: Mortality and End-of-Life Care Associated With Infectious Disease Consultation in an Academic Health System.

Journal Article Clin Infect Dis · October 15, 2024 BACKGROUND: Infectious diseases (ID) physicians are increasingly faced with the challenge of caring for patients with terminal illnesses or incurable infections. METHODS: This was a retrospective cohort of all patients with an ID consult within an academic ... Full text Link to item Cite

Measuring the efficacy of standard and novel disinfection methods on frequently used physical therapy equipment: a 2-phase prospective randomized controlled trial.

Journal Article Infect Control Hosp Epidemiol · July 26, 2024 BACKGROUND: Frequently used physical therapy (PT) equipment is difficult to disinfect due to equipment material and shape. The efficacy of standard disinfection of PT equipment is poorly understood. METHODS: We completed a 2-phase prospective microbiologic ... Full text Link to item Cite

Clinical outcomes in patients with piperacillin/tazobactam-non-susceptible but ceftriaxone-susceptible E. coli or K. pneumoniae bloodstream infection.

Journal Article J Antimicrob Chemother · June 3, 2024 BACKGROUND: A small proportion of Escherichia coli and Klebsiella pneumoniae demonstrate in vitro non-susceptibility to piperacillin/tazobactam but retain susceptibility to ceftriaxone. Uncertainty remains regarding how best to treat these isolates. OBJECT ... Full text Link to item Cite

The devil's in the defaults: An interrupted time-series analysis of the impact of default duration elimination on exposure to fluoroquinolone therapy.

Journal Article Infect Control Hosp Epidemiol · June 2024 OBJECTIVE: To determine whether removal of default duration, embedded in electronic prescription (e-script), influenced antibiotic days of therapy. DESIGN: Interrupted time-series analysis. SETTING: The study was conducted across 2 community hospitals, 1 a ... Full text Link to item Cite

Proposing the "Continuum of UTI" for a Nuanced Approach to Diagnosis and Management of Urinary Tract Infections.

Journal Article J Urol · May 2024 PURPOSE: Patients with suspected UTIs are categorized into 3 clinical phenotypes based on current guidelines: no UTI, asymptomatic bacteriuria (ASB), or UTI. However, all patients may not fit neatly into these groups. Our objective was to characterize clin ... Full text Link to item Cite

Racial disparities in Clostridioides difficile testing in three southeastern US hospitals.

Journal Article Infect Control Hosp Epidemiol · April 2024 OBJECTIVE: To analyze Clostridioides difficile testing in 3 hospitals in central North Carolina to validate previous racial health-disparity findings. METHODS: We completed a retrospective analysis of inpatient C. difficile tests from 2015 to 2021 at 3 uni ... Full text Link to item Cite

CDC's Hospital-Onset Clostridioides difficile Prevention Framework in a Regional Hospital Network.

Journal Article JAMA Netw Open · March 4, 2024 IMPORTANCE: Despite modest reductions in the incidence of hospital-onset Clostridioides difficile infection (HO-CDI), CDI remains a leading cause of health care-associated infection. As no single intervention has proven highly effective on its own, a multi ... Full text Link to item Cite

Racial and Ethnic Disparities in Patient Restraint in Emergency Departments by Police Transport Status.

Journal Article JAMA Netw Open · February 5, 2024 IMPORTANCE: Black patients are more likely than White patients to be restrained during behavioral crises in emergency departments (EDs). Although the perils of policing mental health for Black individuals are recognized, it is unclear whether or to what ex ... Full text Link to item Cite

Racial Inequities in Police Transport for Patients to the Emergency Department: A Multicenter Analysis.

Journal Article Am J Prev Med · January 2024 INTRODUCTION: Police involvement in patient transport to emergency medical care has increased over time, yet studies assessing racial inequities in transport are limited. This study evaluated the relationship between race and police transport to the emerge ... Full text Link to item Cite

Effect of automated identification of antimicrobial stewardship opportunities for suspected urinary tract infections.

Journal Article Antimicrob Steward Healthc Epidemiol · 2024 OBJECTIVE: We aimed to determine whether automated identification of antibiotic targeting suspected urinary tract infection (UTI) shortened the time to antimicrobial stewardship (AS) intervention. DESIGN: Retrospective before-and-after study. SETTING: Tert ... Full text Link to item Cite

Scoping review of percutaneous mechanical aspiration for valvular and cardiac implantable electronic device infective endocarditis.

Journal Article Clin Microbiol Infect · December 2023 BACKGROUND: Percutaneous mechanical aspiration (PMA) of intravascular vegetations is a novel strategy for management of patients with infective endocarditis (IE) who are at high risk of poor outcomes with conventional cardiac surgery. However, clear indica ... Full text Link to item Cite

Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review.

Journal Article Clin Infect Dis · October 16, 2023 The Antibacterial Resistance Leadership Group (ARLG) has prioritized infections caused by gram-positive bacteria as one of its core areas of emphasis. The ARLG Gram-positive Committee has focused on studies responding to 3 main identified research prioriti ... Full text Link to item Cite

Ceftobiprole for Treatment of Complicated Staphylococcus aureus Bacteremia.

Journal Article N Engl J Med · October 12, 2023 BACKGROUND: Ceftobiprole is a cephalosporin that may be effective for treating complicated Staphylococcus aureus bacteremia, including methicillin-resistant S. aureus. METHODS: In this phase 3, double-blind, double-dummy, noninferiority trial, adults with ... Full text Link to item Cite

Assessing the Impact of 2-Step Clostridioides difficile Testing at the Healthcare Facility Level.

Journal Article Clin Infect Dis · October 5, 2023 BACKGROUND: Two-step testing for Clostridioides difficile infection (CDI) aims to improve diagnostic specificity but may also influence reported epidemiology and patterns of treatment. Some providers fear that 2-step testing may result in adverse outcomes ... Full text Link to item Cite

Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial.

Journal Article JAMA Intern Med · September 1, 2023 IMPORTANCE: Fewer than 5% of patients labeled with a penicillin allergy are truly allergic. The standard of care to remove the penicillin allergy label in adults is specialized testing involving prick and intradermal skin testing followed by an oral challe ... Full text Open Access Link to item Cite

Use of Interferon-Gamma Release Assays in Children <2 Years Old.

Journal Article J Pediatric Infect Dis Soc · August 31, 2023 While interferon-gamma release assays (IGRAs) are widely used for detecting tuberculosis (TB) infection, tuberculin skin tests (TSTs) remain preferred for children under the age of 2 years. The preference for TST stems from concern over IGRA sensitivity in ... Full text Link to item Cite

Optimizing reflex urine cultures: Using a population-specific approach to diagnostic stewardship.

Journal Article Infect Control Hosp Epidemiol · February 2023 BACKGROUND: Clinicians and laboratories routinely use urinalysis (UA) parameters to determine whether antimicrobial treatment and/or urine cultures are needed. Yet the performance of individual UA parameters and common thresholds for action are not well de ... Full text Link to item Cite

Using the COM-B model to identify barriers to and facilitators of evidence-based nurse urine-culture practices.

Journal Article Antimicrob Steward Healthc Epidemiol · 2023 Our surveys of nurses modeled after the Capability, Opportunity, and Motivation Model of Behavior (COM-B model) revealed that opportunity and motivation factors heavily influence urine-culture practices (behavior), in addition to knowledge (capability). Un ... Full text Open Access Link to item Cite

Impact of the COVID-19 pandemic on adult mental health-related admissions at a large university health system in North Carolina - one year into the pandemic.

Journal Article PLoS One · 2023 OBJECTIVE: Pandemic-associated stress may have exacerbated preexisting mental health and substance use disorders (MH/SUD) and caused new MH/SUD diagnoses which would be expected to lead to an increase in visits to emergency departments and hospital admissi ... Full text Open Access Link to item Cite

Comparison of metrics used to track central-line-associated bloodstream infections (CLABSIs) and catheter-associated urinary tract infections (CAUTIs) across a regional network.

Journal Article Infect Control Hosp Epidemiol · November 2022 The paradoxical relationship between standardized infection ratio and standardized utilization ratio for catheter-associated urinary tract infections (CAUTIs) in contrast to central-line-associated bloodstream infections (CLABSIs), in addition to CAUTI def ... Full text Link to item Cite

An Enhanced Strategy for Daily Disinfection in Acute Care Hospital Rooms: A Randomized Clinical Trial.

Journal Article JAMA Netw Open · November 1, 2022 IMPORTANCE: Environmental contamination is a source of transmission between patients, health care practitioners, and other stakeholders in the acute care setting. OBJECTIVE: To compare the efficacy of an enhanced daily disinfection strategy vs standard dis ... Full text Link to item Cite

Antibiotic Prophylaxis for Megaprosthetic Reconstructions: Drug and Dosing May Matter More than Duration.

Journal Article Antimicrob Agents Chemother · October 18, 2022 In orthopedic oncology, the implant of a megaprosthetic device is standard of care after large-scale tumor resection involving segmental removal of bone. Infection remains the leading cause of implant failure, often resulting in major morbidity. Perioperat ... Full text Link to item Cite

Landscape of coronavirus disease 2019 clinical trials: New frontiers and challenges.

Journal Article Clin Trials · October 2022 BACKGROUND/AIM: The number of coronavirus disease 2019 deaths and cases continues to increase globally. Novel therapies are urgently needed to treat patients with coronavirus disease 2019. We sought to provide a critical review of trials designed during th ... Full text Link to item Cite

Impact of Education and Data Feedback on Antibiotic Prescribing for Urinary Tract Infections in the Emergency Department: An Interrupted Time-Series Analysis.

Journal Article Clin Infect Dis · September 30, 2022 BACKGROUND: Urinary tract infections (UTIs) are often misdiagnosed or treated with exceedingly broad-spectrum antibiotics, leading to negative downstream effects. We aimed to implement antimicrobial stewardship (AS) strategies targeting UTI prescribing in ... Full text Link to item Cite

Age-Related Changes in the Nasopharyngeal Microbiome Are Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Symptoms Among Children, Adolescents, and Young Adults.

Journal Article Clin Infect Dis · August 24, 2022 BACKGROUND: Children are less susceptible to SARS-CoV-2 infection and typically have milder illness courses than adults, but the factors underlying these age-associated differences are not well understood. The upper respiratory microbiome undergoes substan ... Full text Open Access Link to item Cite

Use of a penicillin allergy clinical decision rule to enable direct oral penicillin provocation: an international multicentre randomised control trial in an adult population (PALACE): study protocol.

Journal Article BMJ Open · August 8, 2022 INTRODUCTION: Penicillin allergies are highly prevalent in the healthcare setting and associated with the prescription of second-line inferior antibiotics. More than 85% of all penicillin allergy labels can be removed by skin testing and 96%-99% of low-ris ... Full text Link to item Cite

Impact of COVID-19 pandemic on pharmacist-led allergy assessments and penicillin skin testing.

Journal Article J Pharm Pract Res · August 2022 Allergy assessments and penicillin skin testing are associated with reductions in high-Clostridioides difficile infection (CDI)-risk antibiotic use and lower hospital-acquired CDI rates; however, these activities require substantial personnel and resource ... Full text Link to item Cite

Clinical Features and Treatment Outcomes of Pulmonary Mycobacterium avium-intracellulare Complex With and Without Coinfections.

Journal Article Open Forum Infect Dis · August 2022 Coinfections are more common in patients with cystic fibrosis and bronchiectasis. Infiltrates on imaging studies are seen more commonly in patients with coinfections, but coinfections did not affect treatment outcomes of pulmonary Mycobacterium avium compl ... Full text Open Access Link to item Cite

Sustained reduction in catheter-associated urinary tract infections using multi-faceted strategies led by champions: A quality improvement initiative.

Journal Article Infect Control Hosp Epidemiol · July 2022 We reviewed the sustainability of a multifaceted intervention on catheter-associated urinary tract infection (CAUTI) in 3 intensive care units. During the 4-year postintervention period, we observed reductions in urine culture rates (from 80.9 to 47.5 per ... Full text Open Access Link to item Cite

In pursuit of the holy grail: Improving C. difficile testing appropriateness with iterative electronic health record clinical decision support and targeted test restriction.

Journal Article Infect Control Hosp Epidemiol · July 2022 OBJECTIVE: To determine the impact of electronic health record (EHR)-based interventions and test restriction on Clostridioides difficile tests (CDTs) and hospital-onset C. difficile infection (HO-CDI). DESIGN: Quasi-experimental study in 3 hospitals. SETT ... Full text Link to item Cite

Association of Black Race With Physical and Chemical Restraint Use Among Patients Undergoing Emergency Psychiatric Evaluation.

Journal Article Psychiatr Serv · July 2022 OBJECTIVE: Few studies have examined the disproportionate use of restraints for Black adults receiving emergency psychiatric care. This study sought to determine whether the odds of physical and chemical restraint use were higher for Black patients undergo ... Full text Link to item Cite

Determination of plasma protein binding of dalbavancin.

Journal Article J Antimicrob Chemother · June 29, 2022 OBJECTIVES: Dalbavancin is a lipoglycopeptide with a long half-life, making it a promising treatment for infections requiring prolonged therapy, such as complicated Staphylococcus aureus bacteraemia. Free drug concentration is a critical consideration with ... Full text Open Access Link to item Cite

Antiplatelet Therapy in Staphylococcus aureus Bacteremia: No Time Like the Past?

Journal Article Antimicrob Agents Chemother · June 21, 2022 In this invited commentary, we reflect on the accompanying study by A. R. Caffrey, H. J. Appaneal, K. L. LaPlante, V. V. Lopes, et al. (Antimicrob Agents Chemother 66:e02117-21, 2022, https://doi.org/10.1128/aac.02117-21), which analyzed the impact of clop ... Full text Open Access Link to item Cite

Impact of Antibiotic Stewardship Rounds in the Intensive Care Setting: A Prospective Cluster-Randomized Crossover Study.

Journal Article Clin Infect Dis · June 10, 2022 BACKGROUND: Few groups have formally studied the effect of dedicated antibiotic stewardship rounds (ASRs) on antibiotic use (AU) in intensive care units (ICUs). METHODS: We implemented weekly ASRs using a 2-arm, cluster-randomized, crossover study in 5 ICU ... Full text Link to item Cite

Dalbavancin as an option for treatment of S. aureus bacteremia (DOTS): study protocol for a phase 2b, multicenter, randomized, open-label clinical trial.

Journal Article Trials · May 16, 2022 BACKGROUND: Staphylococcus aureus bacteremia is a life-threatening infection and leading cause of infective endocarditis, with mortality rates of 15-50%. Treatment typically requires prolonged administration of parenteral therapy, itself associated with hi ... Full text Open Access Link to item Cite

The Impact of Infection Versus Colonization on Clostridioides difficile Environmental Contamination in Hospitalized Patients With Diarrhea.

Journal Article Open Forum Infect Dis · April 2022 BACKGROUND: Patients with Clostridioides difficile infections (CDIs) contaminate the healthcare environment; however, the relative contribution of contamination by colonized individuals is unknown. Current guidelines do not recommend the use of contact pre ... Full text Link to item Cite

COVID-19 Trials: Who Participates and Who Benefits?

Journal Article South Med J · April 2022 OBJECTIVES: The coronavirus disease 2019 (COVID-19) pandemic has disproportionately afflicted vulnerable populations. Older adults, particularly residents of nursing facilities, represent a small percentage of the population but account for 40% of mortalit ... Full text Open Access Link to item Cite

Impact of Oral Metronidazole, Vancomycin, and Fidaxomicin on Host Shedding and Environmental Contamination With Clostridioides difficile.

Journal Article Clin Infect Dis · March 1, 2022 BACKGROUND: Shedding of Clostridioides difficile spores from infected individuals contaminates the hospital environment and contributes to infection transmission. We assessed whether antibiotic selection affects C. difficile shedding and contamination of t ... Full text Link to item Cite

Investigating Risk Factors for Urine Culture Contamination in Outpatient Clinics: A New Avenue for Diagnostic Stewardship.

Journal Article Antimicrob Steward Healthc Epidemiol · 2022 Mixed flora in urine cultures usually occur due to pre-analytic contamination. In our outpatient urology clinic, we found a high prevalence of mixed flora (46.2%), which was associated with female sex and older age. Patient education did not impact the rat ... Full text Link to item Cite

Risk factors for mortality and progression to severe COVID-19 disease in the Southeast region in the United States: A report from the SEUS Study Group.

Journal Article Infect Control Hosp Epidemiol · December 2021 OBJECTIVE: Identify risk factors that could increase progression to severe disease and mortality in hospitalized SARS-CoV-2 patients in the Southeast region of the United States. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, retrospective cohort includin ... Full text Link to item Cite

Severe Acute Respiratory Syndrome Coronavirus 2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study.

Journal Article Clin Infect Dis · November 2, 2021 BACKGROUND: Child with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection typically have mild symptoms that do not require medical attention, leaving a gap in our understanding of the spectrum of SARS-CoV-2-related illnesses that the vi ... Full text Open Access Link to item Cite

Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents.

Journal Article JCI Insight · September 8, 2021 As SARS-CoV-2 continues to spread globally, questions have emerged regarding the strength and durability of immune responses in specific populations. In this study, we evaluated humoral immune responses in 69 children and adolescents with asymptomatic or m ... Full text Link to item Cite

A Cluster of Nontuberculous Mycobacterial Tenosynovitis Following Hurricane Relief Efforts.

Journal Article Clin Infect Dis · June 15, 2021 BACKGROUND: Nontuberculous mycobacteria (NTM) are a rare cause of infectious tenosynovitis of the upper extremity. Using molecular methods, clinical microbiology laboratories are increasingly reporting identification down to the species level. Improved met ... Full text Open Access Link to item Cite

Social Disadvantage, Politics, and Severe Acute Respiratory Syndrome Coronavirus 2 Trends: A County-level Analysis of United States Data.

Journal Article Clin Infect Dis · May 18, 2021 BACKGROUND: Understanding the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for public health control efforts. Social, demographic, and political characteristics at the United States (US) county level might be as ... Full text Open Access Link to item Cite

Evaluation of a Pharmacist-Led Penicillin Allergy Assessment Program and Allergy Delabeling in a Tertiary Care Hospital.

Journal Article JAMA Netw Open · May 3, 2021 IMPORTANCE: Penicillin allergies are frequently mislabeled, which may contribute to use of less-preferred alternative antibiotics. OBJECTIVE: To evaluate a pharmacist-led allergy assessment program's association with antimicrobial use and clinical outcomes ... Full text Link to item Cite

Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents.

Journal Article medRxiv · April 20, 2021 As SARS-CoV-2 continues to spread globally, questions have emerged regarding the strength and durability of immune responses in specific populations. In this study, we evaluated humoral immune responses in 69 children and adolescents with asymptomatic or m ... Full text Link to item Cite

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.

Journal Article Nat Commun · April 15, 2021 Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate the effects of hydroxychloroquine a ... Full text Open Access Link to item Cite

Variability in the Management of Adults With Pulmonary Nontuberculous Mycobacterial Disease.

Journal Article Clin Infect Dis · April 8, 2021 BACKGROUND: The increasing global prevalence of pulmonary nontuberculous mycobacteria (NTM) disease has called attention to challenges in NTM diagnosis and management. This study was conducted to understand management and outcomes of patients with pulmonar ... Full text Link to item Cite

Uncovering the Harms of Treating Clostridioides difficile Colonization.

Journal Article mSphere · January 13, 2021 Patients with toxin-negative Clostridioides difficile-positive diarrhea are often treated with oral vancomycin with the assumption that treatment is more beneficial than harmful. However, this hypothesis has never been formally tested, and recent studies s ... Full text Open Access Link to item Cite

Racial, Ethnic, and Geographic Disparities in Novel Coronavirus (Severe Acute Respiratory Syndrome Coronavirus 2) Test Positivity in North Carolina.

Journal Article Open Forum Infect Dis · January 2021 BACKGROUND: Emerging evidence suggests that black and Hispanic communities in the United States are disproportionately affected by coronavirus disease 2019 (COVID-19). A complex interplay of socioeconomic and healthcare disparities likely contribute to dis ... Full text Open Access Link to item Cite

Rapidly Growing Mycobacterial Infections in Transplant: Evolving Epidemiology and Treatment Options

Chapter · January 1, 2021 Rapidly growing mycobacteria (RGM) are environmental microorganisms that thrive in water-associated biofilms and grow more quickly in the laboratory than slow-growing nontuberculous mycobacteria. Prevalence of RGM infection appears to be increasing, and pa ... Full text Cite

Measuring the impact of continuous disinfection strategies on environmental burden in outpatient settings: A prospective randomized controlled trial

Journal Article Open Forum Infectious Diseases · October 1, 2020 Background. Our primary objective was to determine the effectiveness of 2 enhanced disinfection strategies compared with standard disinfection: “near-UV” light (Arm 1) and a persistent organosilane quaternary ammonium disinfectant (Arm 2) using a triple-bl ... Full text Cite

Efficacy of UV-C Disinfection in Hyperbaric Chambers

Conference Infection Control & Hospital Epidemiology · October 2020 Background: UV-C light reduces contamination of high-touch clinical surfaces. Few studies have tested the relative efficacy of UV-C devices in real-world clinical environments. Methods: We assessed the ... Full text Cite

Efficacy of UV-C disinfection in hyperbaric chambers.

Journal Article Infect Control Hosp Epidemiol · September 2020 Ultraviolet C (UV-C) light reduces contamination on high-touch clinical surfaces. We assessed the efficacy of 2 UV-C devices at eradicating important clinical pathogens in hyperbaric chambers. Both devices were similarly efficacious against MRSA but differ ... Full text Open Access Link to item Cite

Healthcare associated diarrhea, not Clostridioides difficile.

Journal Article Curr Opin Infect Dis · August 2020 PURPOSE OF REVIEW: The aim of this article is to review the epidemiology, cause, diagnostic evaluation, and management of healthcare-associated diarrhea (HCAD) with particular attention to current epidemiology and recent developments in diagnostics. RECENT ... Full text Link to item Cite

Positive follow-up blood cultures identify high mortality risk among patients with Gram-negative bacteraemia.

Journal Article Clin Microbiol Infect · July 2020 OBJECTIVES: The role of follow-up blood cultures (FUBCs) in the management of Gram-negative bacteraemia (GNB) is poorly understood. We aimed to determine the utility of FUBCs in identifying patients with increased mortality risk. METHODS: An observational ... Full text Open Access Link to item Cite

Optimizing the Design of Latent Tuberculosis Treatment Trials: Insights from Mathematical Modeling.

Journal Article Am J Respir Crit Care Med · March 1, 2020 Rationale: Noninferiority trials of treatment for latent tuberculosis infection (LTBI) are challenging because of imperfect LTBI diagnostic tests.Objectives: To assess the effect on study outcomes of different enrollment strategies for a noninferiority tri ... Full text Link to item Cite

Hospital Infection Control: Clostridioides difficile.

Journal Article Clin Colon Rectal Surg · March 2020 Clostridioides difficile remains a leading cause of healthcare-associated infection. Efforts at C. difficile prevention have been hampered by an increasingly complex understanding of transmission patterns and a high degree of heterogeneity among existing s ... Full text Open Access Link to item Cite

Addressing the Menace of Enterococcal Endocarditis.

Journal Article J Am Coll Cardiol · February 11, 2020 Full text Open Access Link to item Cite

Social Disadvantage, Politics, and SARS-CoV-2 Trends: A County-Level Analysis of United States Data

Journal Article · 2020 Background Understanding the epidemiology of SARS-CoV-2 is essential for public health control efforts. Social, demographic, and political characteristics at the US county level might be associated with the trajectories of SARS-CoV-2 case incidenc ... Full text Cite

Epidemiologic Trends in Clostridioides difficile Infections in a Regional Community Hospital Network.

Journal Article JAMA Netw Open · October 2, 2019 IMPORTANCE: Clostridioides difficile infection (CDI) remains a leading cause of health care facility-associated infection. A greater understanding of the regional epidemiologic profile of CDI could inform targeted prevention strategies. OBJECTIVES: To asse ... Full text Open Access Link to item Cite

Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.

Journal Article Nat Rev Microbiol · April 2019 Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, endocarditi ... Full text Open Access Link to item Cite

Use of Letermovir as Salvage Therapy for Drug-Resistant Cytomegalovirus Retinitis.

Journal Article Antimicrob Agents Chemother · March 2019 Treatment options for drug-resistant cytomegalovirus (CMV) are limited. Letermovir is a novel antiviral recently approved for CMV prophylaxis following hematopoietic cell transplantation, but its efficacy in other settings is unknown. We recently used lete ... Full text Open Access Link to item Cite

Influence of Reported Penicillin Allergy on Mortality in MSSA Bacteremia.

Journal Article Open Forum Infect Dis · March 2018 BACKGROUND: Penicillin allergy frequently impacts antibiotic choice. As beta-lactams are superior to vancomycin in treating methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, we examined the effect of reported penicillin allergy on clinical o ... Full text Open Access Link to item Cite

Improving adherence to hepatitis C screening guidelines.

Journal Article BMJ Open Qual · 2018 BACKGROUND: Hepatitis C (HCV) is a viral liver disease that can result in cirrhosis, hepatocellular carcinoma, liver transplantation or death. The Centers for Disease Control (CDC) estimates that 2.7-3.9 million Americans are living with HCV, yet the major ... Full text Open Access Link to item Cite

Mating pair formation homologue TraG is a variable membrane protein essential for contact-independent type IV secretion of chromosomal DNA by Neisseria gonorrhoeae.

Journal Article J Bacteriol · April 2013 Neisseria gonorrhoeae uses a type IV secretion system (T4SS) to secrete chromosomal DNA into the surrounding milieu. The DNA is effective in transforming gonococci in the population, and this mechanism of DNA donation may contribute to the high degree of g ... Full text Link to item Cite

WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4.

Journal Article Blood · July 5, 2012 WHIM syndrome is a rare, autosomal dominant, immunodeficiency disorder so-named because it is characterized by warts, hypogammaglobulinemia, infections, and myelokathexis (defective neutrophil egress from the BM). Gain-of-function mutations that truncate t ... Full text Link to item Cite

A novel relaxase homologue is involved in chromosomal DNA processing for type IV secretion in Neisseria gonorrhoeae.

Journal Article Mol Microbiol · November 2007 The Neisseria gonorrhoeae type IV secretion system secretes chromosomal DNA that acts in natural transformation. To examine the mechanism of DNA processing for secretion, we made mutations in the putative relaxase gene traI and used nucleases to characteri ... Full text Link to item Cite

Antihyperalgesic effects of vanilloid-1 and bradykinin-1 receptor antagonists following spinal cord injury in rats.

Journal Article J Neurosurg Spine · May 2007 OBJECT: The authors previously discovered that genes for the bradykinin-1 (B1) receptor and the transient receptor potential vanilloid subtype 1 (TRPV1) were overexpressed in animals exhibiting thermal hyperalgesia (TH) following spinal cord injury (SCI). ... Full text Link to item Cite

B1 and TRPV-1 receptor genes and their relationship to hyperalgesia following spinal cord injury.

Journal Article Spine (Phila Pa 1976) · November 15, 2006 STUDY DESIGN: Laboratory investigation of pain behavior following spinal cord injury. OBJECTIVE: To explore changes in the spinal cord expression of nociceptive genes following spinal cord injury (SCI) as they relate to the manifestation of pain behavior i ... Full text Link to item Cite

Confirming dioecy in Isoëtes butleri

Journal Article American Fern Journal · January 1, 2005 Full text Cite