Scholars@Duke
Rajendra A. Morey

Rajendra A. Morey

Professor of Psychiatry and Behavioral Sciences
Psychiatry, Child & Family Mental Health & Community Psychiatry
rajendra.morey@duke.edu
Box 3918 Med Ctr, Durham, NC 27710
Brain Imaging Analy Ctr, Hock Plaza, Room 5158, Durham, NC 27710

Selected Publications

A potential target for noninvasive neuromodulation of PTSD symptoms derived from focal brain lesions in veterans.

Journal Article Nat Neurosci · November 2024 Neuromodulation trials for the treatment of posttraumatic stress disorder (PTSD) have yielded mixed results, and the optimal neuroanatomical target remains unclear. Here we analyzed three datasets to study brain circuitry causally linked to PTSD in militar ... Full text Link to item Cite

Black Americans With Sickle Cell Disease (SCD) Demonstrate Accelerated Epigenetic Pace of Aging Compared to Black Americans Without SCD.

Journal Article J Gerontol A Biol Sci Med Sci · November 1, 2024 BACKGROUND: Sickle cell disease (SCD) is a chronic medical condition characterized by red blood cell sickling, vaso-occlusion, hemolytic anemia, and subsequently, end-organ damage and reduced survival. Because of this significant pathophysiology and early ... Full text Link to item Cite

Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture.

Journal Article Transl Psychiatry · October 24, 2024 Genetic contributions to human cortical structure manifest pervasive pleiotropy. This pleiotropy may be harnessed to identify unique genetically-informed parcellations of the cortex that are neurobiologically distinct from functional, cytoarchitectural, or ... Full text Link to item Cite

Bridging big data in the ENIGMA consortium to combine non-equivalent cognitive measures.

Journal Article Scientific reports · October 2024 Investigators in neuroscience have turned to Big Data to address replication and reliability issues by increasing sample size. These efforts unveil new questions about how to integrate data across distinct sources and instruments. The goal of this study wa ... Full text Cite

Effects of mTBI with loss of consciousness on neurobehavioral symptoms, depression, and insomnia in former collegiate and NFL football athletes.

Journal Article Brain Inj · September 18, 2024 OBJECTIVE: Considering that diagnostic decisions about mTBI are often predicated on clinical symptom criteria, it is imperative to determine which initial presentation features of mTBI have prognostic significance for identifying those at high risk for lon ... Full text Link to item Cite

Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis.

Journal Article Brain Sci · June 29, 2024 Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by evaluating how memo ... Full text Link to item Cite

Influence of affective instability on suicidal ideation beyond traumatic brain injury and posttraumatic stress disorder in veterans.

Journal Article J Psychiatr Res · April 2024 OBJECTIVE: Mild traumatic brain injury (TBI) is associated with long-term consequences, including greater risk for posttraumatic stress disorder (PTSD) and suicidal ideation. Affective instability is also independently related to PTSD and suicidality, whic ... Full text Link to item Cite

Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods.

Journal Article Neuropsychopharmacology · February 2024 Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insular cortices in diverse trauma-affected samples. However, some studies have failed to detect differences between PTSD patients and healt ... Full text Link to item Cite

Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans.

Journal Article Transl Psychiatry · January 6, 2024 People who experience trauma and develop posttraumatic stress disorder (PTSD) are at increased risk for poor health. One mechanism that could explain this risk is accelerated biological aging, which is associated with the accumulation of chronic diseases, ... Full text Open Access Link to item Cite

The Genetic Architecture of Amygdala Nuclei.

Journal Article Biol Psychiatry · January 1, 2024 BACKGROUND: Whereas genetic variants influencing total amygdala volume have been identified, the genetic architecture of its distinct nuclei has yet to be explored. We aimed to investigate whether increased phenotypic specificity through nuclei segmentatio ... Full text Link to item Cite

Intrusive Traumatic Re-Experiencing Domain: Functional Connectivity Feature Classification by the ENIGMA PTSD Consortium.

Journal Article Biol Psychiatry Glob Open Sci · January 2024 BACKGROUND: Intrusive traumatic re-experiencing domain (ITRED) was recently introduced as a novel perspective on posttraumatic psychopathology, proposing to focus research of posttraumatic stress disorder (PTSD) on the unique symptoms of intrusive and invo ... Full text Link to item Cite

Intermittent theta burst stimulation and functional connectivity in people living with HIV/AIDS who smoke tobacco cigarettes: a preliminary pilot study.

Journal Article Front Psychiatry · 2024 BACKGROUND: People living with HIV (PLWHA) smoke at three times the rate of the general population and respond poorly to cessation strategies. Previous studies examined repetitive transcranial magnetic stimulation (rTMS) over left dorsolateral prefrontal c ... Full text Link to item Cite

ENIGMA's simple seven: Recommendations to enhance the reproducibility of resting-state fMRI in traumatic brain injury.

Journal Article Neuroimage Clin · 2024 Resting state functional magnetic resonance imaging (rsfMRI) provides researchers and clinicians with a powerful tool to examine functional connectivity across large-scale brain networks, with ever-increasing applications to the study of neurological disor ... Full text Link to item Cite

Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium.

Journal Article Neuroimage · December 1, 2023 BACKGROUND: Recent advances in data-driven computational approaches have been helpful in devising tools to objectively diagnose psychiatric disorders. However, current machine learning studies limited to small homogeneous samples, different methodologies, ... Full text Open Access Link to item Cite

Precision functional MRI mapping reveals distinct connectivity patterns for depression associated with traumatic brain injury.

Journal Article Sci Transl Med · July 5, 2023 Depression associated with traumatic brain injury (TBI) is believed to be clinically distinct from primary major depressive disorder (MDD) and may be less responsive to conventional treatments. Brain connectivity differences between the dorsal attention ne ... Full text Link to item Cite

Harmonizing PTSD severity scales across instruments and sites.

Journal Article Neuropsychology · May 2023 OBJECTIVE: The variety of instruments used to assess posttraumatic stress disorder (PTSD) allows for flexibility, but also creates challenges for data synthesis. The objective of this work was to use a multisite mega analysis to derive quantitative recomme ... Full text Link to item Cite

Network Centrality and Modularity of Structural Covariance Networks in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study.

Journal Article Brain Connect · May 2023 Introduction: Cortical thickness (CT) and surface area (SA) are established biomarkers of brain pathology in posttraumatic stress disorder (PTSD). Structural covariance networks (SCNs) are represented as graphs with brain regions as nodes and correlations ... Full text Link to item Cite

Bridging Big Data: Procedures for Combining Non-equivalent Cognitive Measures from the ENIGMA Consortium.

Journal Article bioRxiv · April 7, 2023 Investigators in neuroscience have turned to Big Data to address replication and reliability issues by increasing sample sizes, statistical power, and representativeness of data. These efforts unveil new questions about integrating data arising from distin ... Full text Link to item Cite

Altered lateralization of the cingulum in deployment-related traumatic brain injury: An ENIGMA military-relevant brain injury study.

Journal Article Hum Brain Mapp · April 1, 2023 Traumatic brain injury (TBI) in military populations can cause disruptions in brain structure and function, along with cognitive and psychological dysfunction. Diffusion magnetic resonance imaging (dMRI) can detect alterations in white matter (WM) microstr ... Full text Link to item Cite

Concurrent validity and reliability of suicide risk assessment instruments: A meta-analysis of 20 instruments across 27 international cohorts.

Journal Article Neuropsychology · March 2023 OBJECTIVE: A major limitation of current suicide research is the lack of power to identify robust correlates of suicidal thoughts or behavior. Variation in suicide risk assessment instruments used across cohorts may represent a limitation to pooling data i ... Full text Link to item Cite

The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study.

Journal Article Biol Psychiatry · February 15, 2023 BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) and posttraumatic stress disorder (PTSD) are associated, but it is unclear if this is a causal relationship or confounding. We used genetic analyses and sibling comparisons to clarify the directio ... Full text Open Access Link to item Cite

Adolescent alcohol use is linked to disruptions in age-appropriate cortical thinning: an unsupervised machine learning approach.

Journal Article Neuropsychopharmacology · January 2023 Cortical thickness changes dramatically during development and is associated with adolescent drinking. However, previous findings have been inconsistent and limited by region-of-interest approaches that are underpowered because they do not conform to the u ... Full text Link to item Cite

Probable trauma associated sleep disorder in post-9/11 US Veterans.

Journal Article Sleep Adv · 2023 STUDY OBJECTIVES: The purpose of this study was to (1) estimate trauma associated sleep disorder (TASD) prevalence among post-9/11 era veterans and to describe differences in service and comorbid mental health clinical characteristics among individuals wit ... Full text Open Access Link to item Cite

Trauma history in veterans with bipolar disorder and its impact on suicidality

Journal Article Journal of Psychiatric Research · January 1, 2023 Objectives: Veterans are at increased risk for exposure to trauma, developing serious mental illnesses, and death by suicide. History of trauma correlates with worsening outcomes in patients with bipolar disorder. This study investigated associations betwe ... Full text Cite

A comparison of methods to harmonize cortical thickness measurements across scanners and sites.

Journal Article Neuroimage · November 1, 2022 Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants' demographic and clinical characteristics, as well as MRI acquisition protocols and scanning platforms. We compared the impact of four d ... Full text Link to item Cite

Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium.

Journal Article Biol Psychiatry Cogn Neurosci Neuroimaging · September 2022 BACKGROUND: Posttraumatic stress disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical th ... Full text Link to item Cite

Investigating the relationship between mild traumatic brain injury and Alzheimer's disease and related dementias: a systematic review.

Journal Article J Neurol · September 2022 The objective of this systematic review is to synthesize the relevant literature published after 2016 to ascertain the current landscape of science that relates mild traumatic brain injury (mTBI) to the onset of Alzheimer's disease and related dementias (A ... Full text Link to item Cite

ENIGMA HALFpipe: Interactive, reproducible, and efficient analysis for resting-state and task-based fMRI data.

Journal Article Hum Brain Mapp · June 15, 2022 The reproducibility crisis in neuroimaging has led to an increased demand for standardized data processing workflows. Within the ENIGMA consortium, we developed HALFpipe (Harmonized Analysis of Functional MRI pipeline), an open-source, containerized, user- ... Full text Link to item Cite

Age-dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury.

Journal Article Hum Brain Mapp · June 1, 2022 Mild Traumatic brain injury (mTBI) is a signature wound in military personnel, and repetitive mTBI has been linked to age-related neurogenerative disorders that affect white matter (WM) in the brain. However, findings of injury to specific WM tracts have b ... Full text Open Access Link to item Cite

Alcohol use and alcohol use disorder differ in their genetic relationships with PTSD: A genomic structural equation modelling approach.

Journal Article Drug Alcohol Depend · May 1, 2022 PURPOSE: Posttraumatic Stress Disorder (PTSD) is associated with increased alcohol use and alcohol use disorder (AUD), which are all moderately heritable. Studies suggest the genetic association between PTSD and alcohol use differs from that of PTSD and AU ... Full text Link to item Cite

Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information.

Journal Article Biol Psychiatry · April 1, 2022 BACKGROUND: Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) info ... Full text Link to item Cite

The impact of climate change on the prevalence of mental illness symptoms.

Journal Article J Affect Disord · March 1, 2022 BACKGROUND: The repercussions of climate change threaten the population with an increased prevalence of extreme climate events. We explored the impact of climate change induced sea level rise (SLR) and tropical cyclone (TC) exposure on mental illness sympt ... Full text Link to item Cite

ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research.

Journal Article Hum Brain Mapp · January 2022 The ENIGMA-DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and developmental disorders on the white matter pathways of the human brain, as well as the effects of normal variation and its gen ... Full text Link to item Cite

FreeSurfer-based segmentation of hippocampal subfields: A review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts.

Journal Article Hum Brain Mapp · January 2022 Structural hippocampal abnormalities are common in many neurological and psychiatric disorders, and variation in hippocampal measures is related to cognitive performance and other complex phenotypes such as stress sensitivity. Hippocampal subregions are in ... Full text Link to item Cite

Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups.

Journal Article Brain Behav · January 2022 BACKGROUND: Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobio ... Full text Link to item Cite

The role of trauma, social support, and demography on veteran resilience.

Journal Article Eur J Psychotraumatol · 2022 BACKGROUND: Historically, resilience has often been conceptualized as the sustained lack of symptoms following trauma exposure. In line with a novel conceptualization of resilience as being dynamic over lifespan, determined by interacting biological and en ... Full text Link to item Cite

Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume.

Journal Article Transl Psychiatry · December 16, 2021 The volume of subcortical structures represents a reliable, quantitative, and objective phenotype that captures genetic effects, environmental effects such as trauma, and disease effects such as posttraumatic stress disorder (PTSD). Trauma and PTSD represe ... Full text Link to item Cite

Warzone experiences and subsequent clinician suicide risk assessment in veterans

Journal Article Suicide and Life-Threatening Behavior · December 1, 2021 Objective: To determine in veterans whether severity of combat exposure was predictive of subsequently receiving a suicide risk assessment (SRA), and whether this relationship was meditated by depression symptomatology. Method: We conducted an electronic m ... Full text Cite

The neurobiology of human fear generalization: meta-analysis and working neural model.

Journal Article Neurosci Biobehav Rev · September 2021 Fear generalization to stimuli resembling a conditioned danger-cue (CS+) is a fundamental dynamic of classical fear-conditioning. Despite the ubiquity of fear generalization in human experience and its known pathogenic contribution to clinical anxiety, neu ... Full text Link to item Cite

Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.

Journal Article Mol Psychiatry · August 2021 A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be partially due to relatively small sample sizes a ... Full text Open Access Link to item Cite

Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis.

Journal Article Mol Psychiatry · August 2021 Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple regions of the cerebral cortex. However, findings for many regions, particularly regions outside commonly studied emotion-related prefrontal, insular, and limbic region ... Full text Link to item Cite

A network analysis of risk factors for suicide in Iraq/Afghanistan-era veterans.

Journal Article J Psychiatr Res · June 2021 Suicidal ideation (SI) is a prevalent issue in the veteran population. A number of factors have been identified as risk factors for suicidal ideation (SI) in veterans, including suicide attempts, depression, posttraumatic stress disorder (PTSD), and drug u ... Full text Link to item Cite

Cannabis use disorder, anger, and violence in Iraq/Afghanistan-era veterans.

Journal Article J Psychiatr Res · June 2021 An association has been found between cannabis use disorder (CUD) and violence in several clinical populations, including veterans with posttraumatic stress disorder (PTSD), and there is evidence that CUD has been increasing among veterans since September ... Full text Link to item Cite

Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Opportunities, Challenges, and Harmonization Guidelines.

Journal Article Brain Imaging Behav · April 2021 Traumatic brain injury (TBI) is common among military personnel and the civilian population and is often followed by a heterogeneous array of clinical, cognitive, behavioral, mood, and neuroimaging changes. Unlike many neurological disorders that have a ch ... Full text Link to item Cite

Volumetric trajectories of hippocampal subfields and amygdala nuclei influenced by adolescent alcohol use and lifetime trauma.

Journal Article Transl Psychiatry · March 2, 2021 Alcohol use and exposure to psychological trauma frequently co-occur in adolescence and share many risk factors. Both exposures have deleterious effects on the brain during this sensitive developmental period, particularly on the hippocampus and amygdala. ... Full text Link to item Cite

Screening for moral injury and comparatively evaluating moral injury measures in relation to mental illness symptomatology and diagnosis.

Journal Article Clin Psychol Psychother · January 2021 Moral injury merits further study to clarify its identification, prevalence, assessment and intersection with psychosocial and psychiatric problems. The present study investigated the screening potential of the Brief Moral Injury Screen (BMIS) in a sample ... Full text Link to item Cite

Assessment of Neuropsychological Function in Veterans With Blast-Related Mild Traumatic Brain Injury and Subconcussive Blast Exposure.

Journal Article Front Psychol · 2021 Objective: The majority of combat-related head injuries are associated with blast exposure. While Veterans with mild traumatic brain injury (mTBI) report cognitive complaints and exhibit poorer neuropsychological performance, there is little evidence exami ... Full text Link to item Cite

Gene Expression Analysis in Three Posttraumatic Stress Disorder Cohorts Implicates Inflammation and Innate Immunity Pathways and Uncovers Shared Genetic Risk With Major Depressive Disorder.

Journal Article Front Neurosci · 2021 Posttraumatic stress disorder (PTSD) is a complex psychiatric disorder that can develop following exposure to traumatic events. The Psychiatric Genomics Consortium PTSD group (PGC-PTSD) has collected over 20,000 multi-ethnic PTSD cases and controls and has ... Full text Open Access Link to item Cite

Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR.

Journal Article Nat Commun · November 24, 2020 Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed controls. Here, we describe the results of the largest DNA methylation meta-analysis of PTSD to date. Ten cohorts, military and civilian, contribute blood-derived DNA meth ... Full text Link to item Cite

Genetic predictors of hippocampal subfield volume in PTSD cases and trauma-exposed controls.

Journal Article Eur J Psychotraumatol · July 29, 2020 Behavioural, structural, and functional neuroimaging have implicated the hippocampus as a critical brain region in posttraumatic stress disorder (PTSD) pathogenesis. Recent work in a normative, primarily European, sample identified 15 unique genetic loci c ... Full text Link to item Cite

Proximal threats promote enhanced acquisition and persistence of reactive fear-learning circuits.

Journal Article Proc Natl Acad Sci U S A · July 14, 2020 Physical proximity to a traumatic event increases the severity of accompanying stress symptoms, an effect that is reminiscent of evolutionarily configured fear responses based on threat imminence. Despite being widely adopted as a model system for stress a ... Full text Link to item Cite

Serum Neurosteroid Levels Are Associated With Cortical Thickness in Individuals Diagnosed With Posttraumatic Stress Disorder and History of Mild Traumatic Brain Injury.

Journal Article Clin EEG Neurosci · July 2020 Posttraumatic stress disorder (PTSD) co-occurring with mild traumatic brain injury (mTBI) is common in veterans. Worse clinical outcome in those with PTSD has been associated with decreased serum neurosteroid levels. Furthermore, decreased cortical thickne ... Full text Link to item Cite

Neural correlates of conceptual-level fear generalization in posttraumatic stress disorder.

Journal Article Neuropsychopharmacology · July 2020 Posttraumatic stress disorder (PTSD) may develop when mechanisms for making accurate distinctions about threat relevance have gone awry. Generalization across conceptually related objects has been hypothesized based on clinical observation in PTSD, but the ... Full text Link to item Cite

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.

Journal Article Transl Psychiatry · March 20, 2020 This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on larg ... Full text Open Access Link to item Cite

The genetic architecture of the human cerebral cortex.

Journal Article Science · March 20, 2020 The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide associati ... Full text Open Access Link to item Cite

Amygdala Nuclei Volume and Shape in Military Veterans With Posttraumatic Stress Disorder.

Journal Article Biol Psychiatry Cogn Neurosci Neuroimaging · March 2020 BACKGROUND: The amygdala is a subcortical structure involved in socioemotional and associative fear learning processes relevant for understanding the mechanisms of posttraumatic stress disorder (PTSD). Research in animals indicates that the amygdala is a h ... Full text Link to item Cite

Threat-induced anxiety during goal pursuit disrupts amygdala-prefrontal cortex connectivity in posttraumatic stress disorder.

Journal Article Transl Psychiatry · February 10, 2020 To investigate how unpredictable threat during goal pursuit impacts fronto-limbic activity and functional connectivity in posttraumatic stress disorder (PTSD), we compared military veterans with PTSD (n = 25) vs. trauma-exposed control (n = 25). Participan ... Full text Link to item Cite

Combat exposure, posttraumatic stress disorder, and head injuries differentially relate to alterations in cortical thickness in military Veterans.

Journal Article Neuropsychopharmacology · February 2020 Combat-exposed Veterans are at increased risk for developing psychological distress, mood disorders, and trauma and stressor-related disorders. Trauma and mood disorders have been linked to alterations in brain volume, function, and connectivity. However, ... Full text Link to item Cite

Classification of PTSD and Non-PTSD Using Cortical Structural Measures in Machine Learning Analyses—Preliminary Study of ENIGMA-Psychiatric Genomics Consortium PTSD Workgroup

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2020 Classification and prediction of posttraumatic stress disorder (PTSD) based on brain imaging measures is important because it could aid in PTSD diagnosis and clinical management of PTSD. The goal of the present study was to test the effectiveness of using ... Full text Cite

A Pilot Study of Neurocognitive Function and Brain Structures in Adolescents With Alcohol Use Disorders: Does Maltreatment History Matter?

Journal Article Child Maltreat · November 2019 Neurocognitive and brain structural differences are associated with adolescent onset alcohol use disorders (AUDs). Maltreatment histories may contribute to current results. To examine these issues, healthy adolescents (n = 31), adolescents without maltreat ... Full text Open Access Link to item Cite

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.

Journal Article Nat Commun · October 8, 2019 The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study ... Full text Open Access Link to item Cite

Resilience as a translational endpoint in the treatment of PTSD.

Journal Article Mol Psychiatry · September 2019 Resilience is a neurobiological entity that shapes an individual's response to trauma. Resilience has been implicated as the principal mediator in the development of mental illness following exposure to trauma. Although animal models have traditionally def ... Full text Link to item Cite

Pain Intensity and Pain Interference in Male and Female Iraq/Afghanistan-era Veterans.

Journal Article Womens Health Issues · June 25, 2019 BACKGROUND: Chronic pain conditions are common among both male and female Iraq/Afghanistan-era veterans and can have substantial negative impacts on quality of life and function. Although in general women tend to report higher levels of pain intensity than ... Full text Link to item Cite

Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder: A Mendelian Randomization Study.

Journal Article JAMA Netw Open · May 3, 2019 IMPORTANCE: There is a well-established negative association of educational attainment (EA) and other traits related to cognitive ability with posttraumatic stress disorder (PTSD), but the underlying mechanisms are poorly understood. OBJECTIVES: To investi ... Full text Link to item Cite

Brain structural covariance network centrality in maltreated youth with PTSD and in maltreated youth resilient to PTSD.

Journal Article Dev Psychopathol · May 2019 Child maltreatment is a major cause of pediatric posttraumatic stress disorder (PTSD). Previous studies have not investigated potential differences in network architecture in maltreated youth with PTSD and those resilient to PTSD. High-resolution magnetic ... Full text Link to item Cite

Resting-state brain fluctuation and functional connectivity dissociate moral injury from posttraumatic stress disorder.

Journal Article Depress Anxiety · May 2019 Moral injury is closely associated with posttraumatic stress disorder (PTSD) and characterized by disturbances in social and moral cognition. Little is known about the neural underpinnings of moral injury, and whether the neural correlates are different be ... Full text Link to item Cite

Adaptive Identification of Cortical and Subcortical Imaging Markers of Early Life Stress and Posttraumatic Stress Disorder.

Journal Article J Neuroimaging · May 2019 BACKGROUND AND PURPOSE: Posttraumatic stress disorder (PTSD) is a heterogeneous condition associated with a range of brain imaging abnormalities. Early life stress (ELS) contributes to this heterogeneity, but we do not know how a history of ELS influences ... Full text Link to item Cite

Relationship between traumatic brain injury history and recent suicidal ideation in Iraq/Afghanistan-era veterans.

Journal Article Psychol Serv · May 2019 This study evaluated whether a history of traumatic brain injury (TBI) was associated with increased risk for recent suicidal ideation (SI) after accounting for demographics, depression, posttraumatic stress disorder (PTSD), and sleep quality. In terms of ... Full text Link to item Cite

Posttraumatic stress disorder and traumatic brain Injury: Sex differences in veterans.

Journal Article Psychiatry Res · April 2019 Around half of Iraq and Afghanistan war veterans with traumatic brain injury (TBI) have co-occurring posttraumatic stress disorder (PTSD). Research on the differences between male and female veterans with co-occurring PTSD/TBI is sparse. This study evaluat ... Full text Link to item Cite

Cigarette smoking rates among veterans: Association with rurality and psychiatric disorders.

Journal Article Addict Behav · March 2019 AIMS: Compared to the general U.S. population, military veterans and those living in rural areas disproportionately smoke cigarettes at higher rates, leading to increased health consequences. In the current study, prevalence and severity of cigarette smoki ... Full text Link to item Cite

Concordance of genetic variation that increases risk for anxiety disorders and posttraumatic stress disorders and that influences their underlying neurocircuitry.

Journal Article J Affect Disord · February 15, 2019 BACKGROUND: There have been considerable recent advances in understanding the genetic architecture of anxiety disorders and posttraumatic stress disorder (PTSD), as well as the underlying neurocircuitry of these disorders. However, there is little work on ... Full text Link to item Cite

The association of resilience on psychiatric, substance use, and physical health outcomes in combat trauma-exposed military service members and veterans.

Journal Article Eur J Psychotraumatol · 2019 Objective: Although Combat exposure is associated with a range of psychiatric outcomes, many veterans do not develop psychopathology. Resilience is a multifaceted construct associated with reduced risk of distress and psychopathology; however, few studies ... Full text Open Access Link to item Cite

Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels.

Journal Article Front Neurosci · 2019 BACKGROUND: Neuroactive steroids are endogenous molecules with regenerative and neuroprotective actions. Both cortical thickness and many neuroactive steroid levels decline with age and are decreased in several neuropsychiatric disorders. However, a system ... Full text Open Access Link to item Cite

Current progress and future direction in the genetics of PTSD: Focus on the development and contributions of the PGC-PTSD working group

Chapter · January 1, 2019 An increasing body of research has focused on elucidating the genetic etiology of posttraumatic stress disorder (PTSD). This chapter first reviews the developments and existing knowledge in the rapidly growing field of PTSD genomics. Next, we describe the ... Full text Cite

Behavioral and Health Outcomes Associated With Deployment and Nondeployment Acquisition of Traumatic Brain Injury in Iraq and Afghanistan Veterans.

Journal Article Arch Phys Med Rehabil · December 2018 OBJECTIVE: To characterize behavioral and health outcomes in veterans with traumatic brain injury (TBI) acquired in nondeployment and deployment settings. DESIGN: Cross-sectional assessment evaluating TBI acquired during and outside of deployment, mental a ... Full text Link to item Cite

Smaller hippocampal CA1 subfield volume in posttraumatic stress disorder.

Journal Article Depress Anxiety · November 2018 BACKGROUND: Smaller hippocampal volume in patients with posttraumatic stress disorder (PTSD) represents the most consistently reported structural alteration in the brain. Subfields of the hippocampus play distinct roles in encoding and processing of memori ... Full text Link to item Cite

Psychosocial Risk Factors and Other Than Honorable Military Discharge: Providing Healthcare to Previously Ineligible Veterans.

Journal Article Mil Med · September 1, 2018 INTRODUCTION: In response to a strong focus on suicide prevention for all veterans, the Department of Veterans Affairs (VA) recently revised policy to provide emergency mental healthcare for veterans who received Other Than Honorable (OTH) discharges from ... Full text Link to item Cite

Informing Federal Policy on Firearm Restrictions for Veterans with Fiduciaries: Risk Indicators in the Post-Deployment Mental Health Study.

Journal Article Adm Policy Ment Health · July 2018 This article examines the public safety rationale for a federal policy of prohibiting gun sales to veterans with psychiatric disabilities who are assigned a fiduciary to manage their benefits from the Department of Veterans Affairs. The policy was evaluate ... Full text Link to item Cite

The Association Between Alcohol Consumption, Lifetime Alcohol Use Disorder, and Psychiatric Distress Among Male and Female Veterans.

Journal Article J Stud Alcohol Drugs · July 2018 OBJECTIVE: This study aimed to examine among veterans (a) whether alcohol consumption patterns are associated with probability of psychiatric symptoms and (b) whether an alcohol use disorder (AUD) history explains psychiatric symptoms among nondrinkers. ME ... Full text Link to item Cite

White matter abnormalities in mild traumatic brain injury with and without post-traumatic stress disorder: a subject-specific diffusion tensor imaging study.

Journal Article Brain Imaging Behav · June 2018 Mild traumatic brain injuries (mTBIs) are often associated with posttraumatic stress disorder (PTSD). In cases of chronic mTBI, accurate diagnosis can be challenging due to the overlapping symptoms this condition shares with PTSD. Furthermore, mTBIs are he ... Full text Link to item Cite

ENIGMA military brain injury: A coordinated meta-analysis of diffusion MRI from multiple cohorts

Conference Proceedings - International Symposium on Biomedical Imaging · May 23, 2018 Traumatic brain injury (TBI) is a significant cause of morbidity in military Veterans and Service Members. While most individuals recover fully from mild injuries within weeks, some continue to experience symptoms including headaches, disrupted sleep, and ... Full text Cite

Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative.

Journal Article Biol Psychiatry · May 15, 2018 Posttraumatic stress disorder (PTSD) after exposure to a traumatic event is a highly prevalent psychiatric disorder. Heritability estimates from twin studies as well as from recent molecular data (single nucleotide polymorphism-based heritability) indicate ... Full text Link to item Cite

Risk factors for concurrent suicidal ideation and violent impulses in military veterans.

Journal Article Psychol Assess · April 2018 Suicide and violence are significant problems in a subset of Iraq/Afghanistan-era veterans. This study investigates how posttraumatic stress disorder (PTSD) and resilience in veterans are associated with suicidal ideation and violent impulses while control ... Full text Link to item Cite

Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.

Journal Article Mol Psychiatry · March 2018 The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-PTSD) combined genome-wide case-control molecular genetic data across 11 multiethnic studies to quantify PTSD heritability, to examine potential shared genetic risk with schizophr ... Full text Open Access Link to item Cite

Structural covariance network centrality in maltreated youth with posttraumatic stress disorder.

Journal Article J Psychiatr Res · March 2018 Childhood maltreatment is associated with posttraumatic stress disorder (PTSD) and elevated rates of adolescent and adult psychopathology including major depression, bipolar disorder, substance use disorders, and other medical comorbidities. Gray matter vo ... Full text Link to item Cite

Multi-site harmonization of diffusion MRI data in a registration framework.

Journal Article Brain imaging and behavior · February 2018 Diffusion MRI (dMRI) data acquired on different scanners varies significantly in its content throughout the brain even if the acquisition parameters are nearly identical. Thus, proper harmonization of such data sets is necessary to increase the sample size ... Full text Cite

Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia.

Journal Article Biol Psychiatry · February 1, 2018 BACKGROUND: Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by ... Full text Link to item Cite

White Matter Changes Related to Subconcussive Impact Frequency during a Single Season of High School Football.

Journal Article AJNR Am J Neuroradiol · February 2018 BACKGROUND AND PURPOSE: The effect of exposing the developing brain of a high school football player to subconcussive impacts during a single season is unknown. The purpose of this pilot study was to use diffusion tensor imaging to assess white matter chan ... Full text Open Access Link to item Cite

Brain Structural Covariance Network Topology in Remitted Posttraumatic Stress Disorder.

Journal Article Front Psychiatry · 2018 Posttraumatic stress disorder (PTSD) is a prevalent, chronic disorder with high psychiatric morbidity; however, a substantial portion of affected individuals experience remission after onset. Alterations in brain network topology derived from cortical thic ... Full text Link to item Cite

Posttraumatic Stress Disorder Symptom Network Analysis in U.S. Military Veterans: Examining the Impact of Combat Exposure.

Journal Article Front Psychiatry · 2018 Recent work inspired by graph theory has begun to conceptualize mental disorders as networks of interacting symptoms. Posttraumatic stress disorder (PTSD) symptom networks have been investigated in clinical samples meeting full diagnostic criteria, includi ... Full text Open Access Link to item Cite

Exploring resilience models in a sample of combat-exposed military service members and veterans: a comparison and commentary.

Journal Article Eur J Psychotraumatol · 2018 Background: The term resilience is applied in numerous ways in the mental health field, leading to different perspectives of what constitutes a resilient response and disparate findings regarding its prevalence following trauma. Objective: illustrate the i ... Full text Link to item Cite

Genome-wide association study of subcortical brain volume in PTSD cases and trauma-exposed controls.

Journal Article Transl Psychiatry · November 30, 2017 Depending on the traumatic event, a significant fraction of trauma survivors subsequently develop PTSD. The additional variability in PTSD risk is expected to arise from genetic susceptibility. Unfortunately, several genome-wide association studies (GWAS) ... Full text Link to item Cite

A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder.

Journal Article Genome Med · November 27, 2017 BACKGROUND: The nature and underlying mechanisms of the observed increased vulnerability to posttraumatic stress disorder (PTSD) in women are unclear. METHODS: We investigated the genetic overlap of PTSD with anthropometric traits and reproductive behavior ... Full text Link to item Cite

Sleep quality in returning veterans: The influence of mild traumatic brain injury.

Journal Article Rehabil Psychol · November 2017 OBJECTIVE: Sleep disturbance is a key behavioral health concern among Iraq and Afghanistan era veterans and is a frequent complaint among veterans with a history of mild traumatic brain injury (mTBI). Currently, it is unclear whether sleep disturbance is a ... Full text Link to item Cite

Self-Reported Pain in Male and Female Iraq/Afghanistan-Era Veterans: Associations with Psychiatric Symptoms and Functioning.

Journal Article Pain Med · September 1, 2017 OBJECTIVE: To examine pain symptoms and co-occurring psychiatric and functional indices in male and female Iraq/Afghanistan-era veterans. DESIGN: Self-reported data collection and interviews of Iraq/Afghanistan-era veterans who participated in a multisite ... Full text Link to item Cite

The Post-Deployment Mental Health (PDMH) study and repository: A multi-site study of US Afghanistan and Iraq era veterans.

Journal Article Int J Methods Psychiatr Res · September 2017 The United States (US) Department of Veterans Affairs (VA) Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC) Post-Deployment Mental Health (PDMH) multi-site study examines post-deployment mental health in US military Afghanistan ... Full text Link to item Cite

Practices and outcomes of self-treatment with helminths based on physicians' observations.

Journal Article J Helminthol · May 2017 The successful use of helminths as therapeutic agents to resolve inflammatory disease was first recorded 40 years ago. Subsequent work in animal models and in humans has demonstrated that the organisms might effectively treat a wide range of inflammatory d ... Full text Open Access Link to item Cite

ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide.

Journal Article Neuroimage · January 15, 2017 In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu) - a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. Initiall ... Full text Open Access Link to item Cite

Inter-site and inter-scanner diffusion MRI data harmonization.

Journal Article Neuroimage · July 15, 2016 We propose a novel method to harmonize diffusion MRI data acquired from multiple sites and scanners, which is imperative for joint analysis of the data to significantly increase sample size and statistical power of neuroimaging studies. Our method incorpor ... Full text Open Access Link to item Cite

Sexual revictimization among Iraq and Afghanistan war era veterans.

Journal Article Psychiatry Res · June 30, 2016 Research in both civilian and military populations has demonstrated that females who experience childhood sexual abuse (CSA) are more likely to experience sexual assault in adulthood than females who did not experience CSA. Among veteran samples, however, ... Full text Link to item Cite

Amygdala, Hippocampus, and Ventral Medial Prefrontal Cortex Volumes Differ in Maltreated Youth with and without Chronic Posttraumatic Stress Disorder.

Journal Article Neuropsychopharmacology · February 2016 Posttraumatic stress disorder (PTSD) is considered a disorder of recovery where individuals fail to learn and retain extinction of the traumatic fear response. In maltreated youth, PTSD is common, chronic, and associated with comorbidity. Studies of extinc ... Full text Open Access Link to item Cite

Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics.

Journal Article Pain Med · January 2016 BACKGROUND AND OBJECTIVES: Pain symptoms are common among Iraq/Afghanistan-era veterans, many of whom continue to experience persistent pain symptoms despite multiple pharmacological interventions. Preclinical data suggest that neurosteroids such as allopr ... Full text Open Access Link to item Cite

Fear learning circuitry is biased toward generalization of fear associations in posttraumatic stress disorder.

Journal Article Transl Psychiatry · December 15, 2015 Fear conditioning is an established model for investigating posttraumatic stress disorder (PTSD). However, symptom triggers may vaguely resemble the initial traumatic event, differing on a variety of sensory and affective dimensions. We extended the fear-c ... Full text Open Access Link to item Cite

Functional correlates of military sexual assault in male veterans.

Journal Article Psychol Serv · November 2015 Despite research findings that similar numbers of male and female veterans are affected by military sexual trauma (MST), there has been considerably less research on the effects of MST specific to male veterans. The aim of the present study was to provide ... Full text Link to item Cite

Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder.

Journal Article Psychiatry Res · September 30, 2015 The present study examined the association between genetic variation in the nicotinic receptor gene family (CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA9, CHRNA10, CHRNB2, CHRNB3, CHRNB4) and the occurrence of posttraumatic stress disorder (PTSD). ... Full text Link to item Cite

The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration.

Journal Article Neuropsychopharmacology · September 2015 The development of posttraumatic stress disorder (PTSD) is influenced by genetic factors. Although there have been some replicated candidates, the identification of risk variants for PTSD has lagged behind genetic research of other psychiatric disorders su ... Full text Open Access Link to item Cite

Drug use and childhood-, military- and post-military trauma exposure among women and men veterans.

Journal Article Drug Alcohol Depend · July 1, 2015 BACKGROUND: The current study was undertaken to examine whether posttraumatic stress symptoms (PTSS) and depressive symptoms mediated the association between trauma exposure (combat-related trauma and non-combat traumas occurring before, during, and after ... Full text Link to item Cite

Amygdala-prefrontal cortex functional connectivity during threat-induced anxiety and goal distraction.

Journal Article Biol Psychiatry · February 15, 2015 BACKGROUND: Anxiety produced by environmental threats can impair goal-directed processing and is associated with a range of psychiatric disorders, particularly when aversive events occur unpredictably. The prefrontal cortex (PFC) is thought to implement co ... Full text Open Access Link to item Cite

White matter compromise in veterans exposed to primary blast forces.

Journal Article J Head Trauma Rehabil · 2015 OBJECTIVE: Use diffusion tensor imaging to investigate white matter alterations associated with blast exposure with or without acute symptoms of traumatic brain injury (TBI). PARTICIPANTS: Forty-five veterans of the recent military conflicts included 23 ex ... Full text Open Access Link to item Cite

Neuroimaging assessment of early and late neurobiological sequelae of traumatic brain injury: implications for CTE.

Journal Article Front Neurosci · 2015 Traumatic brain injury (TBI) has been increasingly accepted as a major external risk factor for neurodegenerative morbidity and mortality. Recent evidence indicates that the resultant chronic neurobiological sequelae following head trauma may, at least in ... Full text Open Access Link to item Cite

The factor structure of psychiatric comorbidity among Iraq/Afghanistan-era veterans and its relationship to violence, incarceration, suicide attempts, and suicidality.

Journal Article Psychiatry Res · December 15, 2014 The present research examined how incarceration, suicide attempts, suicidality, and difficulty controlling violence relate to the underlying factor structure of psychiatric comorbidity among a large sample of Iraq/Afghanistan-era veterans (N=1897). Diagnos ... Full text Link to item Cite

DSM-5 posttraumatic stress disorder: factor structure and rates of diagnosis.

Journal Article J Psychiatr Res · December 2014 Posttraumatic stress disorder (PTSD) is a significant problem among Iraq/Afghanistan-era veterans. To date, however, there has been only limited research on how the recent changes in DSM-5 influence the prevalence and factor structure of PTSD. To address t ... Full text Link to item Cite

Examining the factor structure of the Connor-Davidson Resilience Scale (CD-RISC) in a post-9/11 U.S. military veteran sample.

Journal Article Assessment · August 2014 The present study examined the structural validity of the 25-item Connor-Davidson Resilience Scale (CD-RISC) in a large sample of U.S. veterans with military service since September 11, 2001. Participants (N = 1,981) completed the 25-item CD-RISC, a struct ... Full text Open Access Link to item Cite

The impact of social support on psychological distress for U.S. Afghanistan/Iraq era veterans with PTSD and other psychiatric diagnoses.

Journal Article Psychiatry Res · June 30, 2014 This study aimed to examine the degree to which posttraumatic stress disorder (PTSD) affects the relationship between social support and psychological distress for U.S. Afghanistan/Iraq era veterans with and without co-occurring psychiatric disorders. Vete ... Full text Link to item Cite

Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.

Journal Article Hum Brain Mapp · June 2014 As indicated by several recent studies, magnetic susceptibility of the brain is influenced mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination and iron deposition in the brain evolve both spatially and temporally. This ... Full text Open Access Link to item Cite

Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling.

Journal Article Mil Med · May 2014 Veteran populations are exposed to multiple stressful events, and suicidality among veterans is a serious problem. Identifying biomarkers of suicidality may enhance detection, prevention, and treatment. Multiple neurotransmitter systems are implicated in t ... Full text Link to item Cite

Acute effects of trauma-focused research procedures on participant safety and distress.

Journal Article Psychiatry Res · January 30, 2014 The ethical conduct of research on posttraumatic stress disorder (PTSD) requires assessing the risks to study participants. Some previous findings suggest that patients with PTSD report higher distress compared to non-PTSD participants after trauma-focused ... Full text Open Access Link to item Cite

Altered resting-state functional connectivity of basolateral and centromedial amygdala complexes in posttraumatic stress disorder.

Journal Article Neuropsychopharmacology · January 2014 The amygdala is a major structure that orchestrates defensive reactions to environmental threats and is implicated in hypervigilance and symptoms of heightened arousal in posttraumatic stress disorder (PTSD). The basolateral and centromedial amygdala (CMA) ... Full text Open Access Link to item Cite

Effects of chronic mild traumatic brain injury on white matter integrity in Iraq and Afghanistan war veterans.

Journal Article Hum Brain Mapp · November 2013 Mild traumatic brain injury (TBI) is a common source of morbidity from the wars in Iraq and Afghanistan. With no overt lesions on structural MRI, diagnosis of chronic mild TBI in military veterans relies on obtaining an accurate history and assessment of b ... Full text Open Access Link to item Cite

The Association of Sleep Duration, Mental Health, and Health Risk Behaviors among U.S. Afghanistan/Iraq Era Veterans.

Journal Article Sleep · July 1, 2013 STUDY OBJECTIVES: Short and long sleep duration have been linked with higher rates of comorbid medical and mental health issues, as well as increased mortality. The current study examined the association between sleep duration, mental health problems, and ... Full text Link to item Cite

Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group.

Journal Article Arch Gen Psychiatry · November 2012 CONTEXT: Smaller hippocampal volumes are well established in posttraumatic stress disorder (PTSD), but the relatively few studies of amygdala volume in PTSD have produced equivocal results. OBJECTIVE: To assess a large cohort of recent military veterans wi ... Full text Open Access Link to item Cite

A case of frontal neuropsychological and neuroimaging signs following multiple primary-blast exposure.

Journal Article Neurocase · June 2012 Blast-related traumatic brain injury (TBI) from the Afghanistan and Iraq wars represents a significant medical concern for troops and veterans. To better understand the consequences of primary-blast injury in humans, we present a case of a Marine exposed t ... Full text Open Access Link to item Cite

Neural systems for guilt from actions affecting self versus others.

Journal Article Neuroimage · March 2012 Guilt is a core emotion governing social behavior by promoting compliance with social norms or self-imposed standards. The goal of this study was to contrast guilty responses to actions that affect self versus others, since actions with social consequences ... Full text Open Access Link to item Cite

Brain imaging investigation of the impairing effect of emotion on cognition.

Journal Article J Vis Exp · February 1, 2012 Emotions can impact cognition by exerting both enhancing (e.g., better memory for emotional events) and impairing (e.g., increased emotional distractibility) effects (reviewed in (1)). Complementing our recent protocol (2) describing a method that allows i ... Full text Link to item Cite

Neural systems for cognitive and emotional processing in posttraumatic stress disorder.

Journal Article Front Psychol · 2012 Individuals with posttraumatic stress disorder (PTSD) show altered cognition when trauma-related material is present. PTSD may lead to enhanced processing of trauma-related material, or it may cause impaired processing of trauma-unrelated information. Howe ... Full text Open Access Link to item Cite

Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder.

Journal Article BMC Psychiatry · May 5, 2011 BACKGROUND: Serotonergic system dysfunction has been implicated in posttraumatic stress disorder (PTSD). Genetic polymorphisms associated with serotonin signaling may predict differences in brain circuitry involved in emotion processing and deficits associ ... Full text Open Access Link to item Cite

Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD.

Journal Article J Psychiatr Res · May 2011 Neurobiological models of posttraumatic stress disorder (PTSD) suggest that altered activity in the medial temporal lobes (MTL) during encoding of traumatic memories contribute to the development and maintenance of the disorder. However, there is little di ... Full text Open Access Link to item Cite

Scan-rescan reliability of subcortical brain volumes derived from automated segmentation.

Journal Article Hum Brain Mapp · November 2010 Large-scale longitudinal studies of regional brain volume require reliable quantification using automated segmentation and labeling. However, repeated MR scanning of the same subject, even if using the same scanner and acquisition parameters, does not resu ... Full text Open Access Link to item Cite

Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001.

Journal Article Pain Med · October 2010 OBJECTIVE: Nearly half of Operation Enduring Freedom/Operation Iraqi Freedom veterans experience continued pain post-deployment. Several investigations report analgesic effects of allopregnanolone and other neurosteroids in animal models, but few data are ... Full text Link to item Cite

Correlates of anger and hostility in Iraq and Afghanistan war veterans.

Journal Article Am J Psychiatry · September 2010 OBJECTIVE: As troops return from Iraq and Afghanistan to civilian life, clinicians are starting to grapple with how best to detect those at risk of postdeployment adjustment problems. Data reveal the presence of mental health problems in these soldiers, in ... Full text Link to item Cite

Staying cool when things get hot: emotion regulation modulates neural mechanisms of memory encoding.

Journal Article Front Hum Neurosci · 2010 During times of emotional stress, individuals often engage in emotion regulation to reduce the experiential and physiological impact of negative emotions. Interestingly, emotion regulation strategies also influence memory encoding of the event. Cognitive r ... Full text Open Access Link to item Cite

Rebuttal to Hasan and Pedraza in comments and controversies: "Improving the reliability of manual and automated methods for hippocampal and amygdala volume measurements".

Journal Article Neuroimage · November 15, 2009 Here we address the critiques offered by Hasan and Pedraza to our recently published manuscript comparing the performance of two automated segmentation programs, FSL/FIRST and FreeSurfer (Morey R, Petty C, Xu Y, Pannu Hayes J, Wagner H, Lewis D, LaBar K, S ... Full text Link to item Cite

Association of trauma exposure with psychiatric morbidity in military veterans who have served since September 11, 2001.

Journal Article J Psychiatr Res · June 2009 OBJECTIVE: This study examined the association of lifetime traumatic stress with psychiatric diagnostic status and symptom severity in veterans serving in the US military after 9/11/01. METHOD: Data from 356 US military veterans were analyzed. Measures inc ... Full text Link to item Cite

The role of trauma-related distractors on neural systems for working memory and emotion processing in posttraumatic stress disorder.

Journal Article J Psychiatr Res · May 2009 The relevance of emotional stimuli to threat and survival confers a privileged role in their processing. In PTSD, the ability of trauma-related information to divert attention is especially pronounced. Information unrelated to the trauma may also be highly ... Full text Link to item Cite

Alterations in the neural circuitry for emotion and attention associated with posttraumatic stress symptomatology.

Journal Article Psychiatry Res · April 30, 2009 Information processing models of posttraumatic stress disorder (PTSD) suggest that PTSD is characterized by preferential allocation of attentional resources to potentially threatening stimuli. However, few studies have examined the neural pattern underlyin ... Full text Link to item Cite

A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes.

Journal Article Neuroimage · April 15, 2009 Large databases of high-resolution structural MR images are being assembled to quantitatively examine the relationships between brain anatomy, disease progression, treatment regimens, and genetic influences upon brain structure. Quantifying brain structure ... Full text Link to item Cite

The validity and diagnostic efficiency of the Davidson Trauma Scale in military veterans who have served since September 11th, 2001.

Journal Article J Anxiety Disord · March 2009 The present study examined the psychometric properties and diagnostic efficiency of the Davidson Trauma Scale (DTS), a self-report measure of posttraumatic stress disorder (PTSD) symptoms. Participants included 158 U.S. military veterans who have served si ... Full text Link to item Cite

Factorial invariance of posttraumatic stress disorder symptoms across three veteran samples.

Journal Article J Trauma Stress · June 2008 Research generally supports a 4-factor structure of posttraumatic stress disorder (PTSD) symptoms. However, few studies have established factor invariance by comparing multiple groups. This study examined PTSD symptom structure using the Davidson Trauma Sc ... Full text Link to item Cite

Alcohol use among OEF-OIF veterans with and without posttraumatic stress disorder

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · June 1, 2008 Link to item Cite

Neural systems for executive and emotional processing are modulated by symptoms of posttraumatic stress disorder in Iraq War veterans.

Journal Article Psychiatry Res · January 15, 2008 The symptom-provocation paradigms generally used in neuroimaging studies of posttraumatic stress disorder (PTSD) have placed high demands on emotion processing but lacked cognitive processing, thereby limiting the ability to assess alterations in neural sy ... Full text Link to item Cite

Neural correlates of automatic and controlled auditory processing in schizophrenia.

Journal Article J Neuropsychiatry Clin Neurosci · 2008 Individuals with schizophrenia demonstrate impairments in selective attention and sensory processing. The authors assessed differences in brain function between 26 participants with schizophrenia and 17 comparison subjects engaged in automatic (unattended) ... Full text Link to item Cite

Functional magnetic resonance imaging measure of automatic and controlled auditory processing.

Journal Article Neuroreport · April 4, 2005 Activity within fronto-striato-temporal regions during processing of unattended auditory deviant tones and an auditory target detection task was investigated using event-related functional magnetic resonance imaging. Activation within the middle frontal gy ... Full text Link to item Cite

Imaging frontostriatal function in ultra-high-risk, early, and chronic schizophrenia during executive processing.

Journal Article Arch Gen Psychiatry · March 2005 CONTEXT: Individuals experiencing prodromal symptoms of schizophrenia (ultra-high-risk group) demonstrate impaired performance on tasks of executive function, attention, and working memory. The neurobiological underpinnings of such executive deficits in ul ... Full text Link to item Cite