Scholars@Duke
Shelby Derene Reed

Shelby Derene Reed

Professor in Population Health Sciences
Population Health Sciences
shelby.reed@duke.edu
Duke Box 17969, #6044 North Pavilion, Durham, NC 27715
300 N Mangum Street, Durham, NC 27701

Selected Publications

The impact of violations of expected utility theory on choices in the face of multiple risks

Journal Article Journal of Choice Modelling · December 1, 2024 Use of preference information to infer risk tolerance has increased in recent years as a way to inform benefit-risk evaluations in regulatory and medical decision making. However, a framework for the measurement of tolerance for multiple uncertain outcomes ... Full text Cite

Quantifying patients' preferences on tradeoffs between mortality risk and reduced need for target vessel revascularization for claudication.

Journal Article Vasc Med · December 2024 BACKGROUND: In 2019, the US Food and Drug Administration issued a warning that symptomatic relief from claudication using paclitaxel-coated devices might be associated with an increase in mortality over 5 years. We designed a discrete-choice experiment (DC ... Full text Link to item Cite

Participant Engagement and Preference Study for Clinical Outcomes Associated With Atrial Fibrillation: The PEARL-AF Study.

Journal Article JACC Adv · December 2024 BACKGROUND: Quantifying patients' preferences for health outcomes associated with atrial fibrillation (AF) and its treatments offers a replicable approach to considering the patient perspective in regulatory decision-making. OBJECTIVE: The authors conducte ... Full text Link to item Cite

Patient Preferences for Features Associated With Leadless Versus Conventional Transvenous Cardiac Pacemakers.

Journal Article Circ Cardiovasc Qual Outcomes · November 21, 2024 BACKGROUND: Regulatory approval of the first dual-chamber leadless pacemaker system provides patients an alternative to conventional transvenous pacemakers. The study objective was to quantify the preferences of patients for pacemaker features. METHODS: Pa ... Full text Link to item Cite

Using Separate Single-Outcome Risk Presentations Instead of Integrated Multioutcome Formats Improves Comprehension in Discrete Choice Experiments.

Journal Article Med Decis Making · August 2024 INTRODUCTION: Despite decades of research on risk-communication approaches, questions remain about the optimal methods for conveying risks for different outcomes across multiple time points, which can be necessary in applications such as discrete choice ex ... Full text Link to item Cite

Patient Risk-Benefit Preferences for Transcatheter Versus Surgical Mitral Valve Repair.

Journal Article J Am Heart Assoc · March 19, 2024 BACKGROUND: Transcatheter edge-to-edge repair (TEER) of mitral regurgitation is less invasive than surgery but has greater 5-year mortality and reintervention risks, and leads to smaller improvements in physical functioning. The study objective was to quan ... Full text Link to item Cite

Development and testing of patient-centered education about hormone replacement therapy for women at high genetic risk of breast and ovarian cancer.

Journal Article Gynecol Oncol · February 2024 OBJECTIVE: In this study, we aimed to develop education to assist BRCA mutation carriers in making informed decisions about HRT in the context of risk-reducing surgery, while simultaneously clarifying their treatment-specific values and reducing decisional ... Full text Link to item Cite

Stated-Preference Survey Design and Testing in Health Applications.

Journal Article Patient · January 31, 2024 Following the conceptualization of a well-formulated and relevant research question, selection of an appropriate stated-preference method, and related methodological issues, researchers are tasked with developing a survey instrument. A major goal of design ... Full text Link to item Cite

Preferences for potential benefits and risks for gene therapy in the treatment of sickle cell disease.

Journal Article Blood Adv · December 12, 2023 Objective of this study is to quantify benefit-risk tradeoffs pertaining to potential gene therapies among adults and parents/caregivers of children with sickle cell disease (SCD). A discrete-choice experiment survey was developed in which respondents sele ... Full text Link to item Cite

Patient Preferences for Postmastectomy Breast Reconstruction.

Journal Article JAMA Surg · December 1, 2023 IMPORTANCE: Up to 40% of women experience dissatisfaction after breast reconstruction due to unexpected outcomes that are poorly aligned with personal preferences. Identifying what attributes patients value when considering surgery could improve shared dec ... Full text Link to item Cite

Meaning-centered pain coping skills training for patients with metastatic cancer: Protocol for a randomized controlled efficacy trial.

Journal Article Contemp Clin Trials · December 2023 BACKGROUND: Many patients with advanced cancer describe pain as a debilitating symptom that greatly interferes with daily activities and enjoyment of life. Psychosocial interventions can improve cancer-related pain but rarely address spiritual concerns (e. ... Full text Link to item Cite

Relationship of Race With Functional and Clinical Outcomes With the REHAB-HF Multidomain Physical Rehabilitation Intervention for Older Patients With Acute Heart Failure.

Journal Article J Am Heart Assoc · November 7, 2023 Background The REHAB-HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) randomized trial demonstrated that a 3-month transitional, tailored, progressive, multidomain physical rehabilitation intervention improves physical function, frailty, d ... Full text Link to item Cite

Behavioral cancer pain intervention dosing: results of a Sequential Multiple Assignment Randomized Trial.

Journal Article Pain · September 1, 2023 Behavioral pain management interventions are efficacious for reducing pain in patients with cancer. However, optimal dosing of behavioral pain interventions for pain reduction is unknown, and this hinders routine clinical use. A Sequential Multiple Assignm ... Full text Link to item Cite

Cost-Effectiveness Analysis Evaluating Delivery Strategies for Pain Coping Skills Training in Women With Breast Cancer.

Journal Article J Pain · September 2023 Pain coping skills training (PCST) is efficacious in patients with cancer, but clinical access is limited. To inform implementation, as a secondary outcome, we estimated the cost-effectiveness of 8 dosing strategies of PCST evaluated in a sequential multip ... Full text Link to item Cite

Development and Validation of a Tool to Identify Patients Diagnosed With Castration-Resistant Prostate Cancer.

Journal Article JCO Clin Cancer Inform · September 2023 PURPOSE: Several novel therapies for castration-resistant prostate cancer (CRPC) have been approved with randomized phase III studies with continuing observational research either planned or ongoing. Accurately identifying patients with CRPC in electronic ... Full text Link to item Cite

How Much Better is Faster? Value Adjustments for Health-Improvement Sequences.

Journal Article Pharmacoeconomics · August 2023 While the quality-adjusted life-year construct has advantages of simplicity and consistency, simplicity requires strong assumptions. In particular, standard assumptions result in health-state utility functions that are unrealistically linear and separable ... Full text Link to item Cite

Mapping Factors That Affect the Uptake of Digital Therapeutics Within Health Systems: Scoping Review.

Journal Article J Med Internet Res · July 25, 2023 BACKGROUND: Digital therapeutics are patient-facing digital health interventions that can significantly alter the health care landscape. Despite digital therapeutics being used to successfully treat a range of conditions, their uptake in health systems rem ... Full text Link to item Cite

Patient-Centered Clinical Trial Design for Heart Failure Devices via Bayesian Decision Analysis.

Journal Article Patient · July 2023 BACKGROUND: The statistical significance of clinical trial outcomes is generally interpreted quantitatively according to the same threshold of 2.5% (in one-sided tests) to control the false-positive rate or type I error, regardless of the burden of disease ... Full text Link to item Cite

Patient-Preference Diagnostics: Adapting Stated-Preference Methods to Inform Effective Shared Decision Making.

Journal Article Med Decis Making · February 2023 BACKGROUND: While clinical practice guidelines underscore the need to incorporate patient preferences in clinical decision making, incorporating meaningful assessment of patient preferences in clinical encounters is challenging. Structured approaches that ... Full text Open Access Link to item Cite

Method for Calculating the Simultaneous Maximum Acceptable Risk Threshold (SMART) from Discrete-Choice Experiment Benefit-Risk Studies.

Journal Article Med Decis Making · February 2023 BACKGROUND: Medical decisions require weighing expected benefits of treatment against multiple adverse outcomes under uncertainty (i.e., risks) that must be accepted as a bundle. However, conventional maximum acceptable risk (MAR) estimates derived from di ... Full text Link to item Cite

The Impact of Hearing Loss and Its Treatment on Health-Related Quality of Life Utility: a Systematic Review with Meta-analysis.

Journal Article J Gen Intern Med · February 2023 BACKGROUND: Hearing loss significantly impacts health-related quality of life (QoL), yet the effects of current treatments on QoL utility remain uncertain. Our objective was to describe the impact of untreated and treated hearing loss on QoL utility to inf ... Full text Link to item Cite

Leveraging Patient Preference Information in Medical Device Clinical Trial Design.

Journal Article Ther Innov Regul Sci · January 2023 Use of robust, quantitative tools to measure patient perspectives within product development and regulatory review processes offers the opportunity for medical device researchers, regulators, and other stakeholders to evaluate what matters most to patients ... Full text Link to item Cite

Use of Patient Preferences Data Regarding Multiple Risks to Inform Regulatory Decisions.

Journal Article MDM Policy Pract · 2023 UNLABELLED: Background and Objectives. Risk-tolerance measures from patient-preference studies typically focus on individual adverse events. We recently introduced an approach that extends maximum acceptable risk (MAR) calculations to simultaneous maximum ... Full text Link to item Cite

Tumor testing and treatment patterns in veterans with metastatic castration-resistant prostate cancer.

Journal Article Semin Oncol · 2023 INTRODUCTION: In 2016, the Department of Veterans Affairs (VA) and Prostate Cancer Foundation (PCF) began a partnership to improve access to testing. The primary objective of this analysis was to describe the use of tumor testing and treatment patterns in ... Full text Link to item Cite

Quality of Life Trajectory and Its Mediators in Older Patients With Acute Decompensated Heart Failure Receiving a Multi-Domain Rehabilitation Intervention: Results From the Rehabilitation Therapy in Older Acute Heart Failure Patients Trial.

Journal Article Circ Heart Fail · December 2022 BACKGROUND: As patients with heart failure experience worsening of their condition, including acute decompensated heart failure, quality of life deteriorates. However, the trajectory of quality of life changes and their determinants in the context of the R ... Full text Link to item Cite

Improving well-being for individuals with persistent pain after surgery for breast cancer, lobular carcinoma in situ, or ductal carcinoma in situ: A randomized clinical trial.

Journal Article Contemp Clin Trials · November 2022 >276,000 Americans will be diagnosed with invasive breast cancer, lobular carcinoma in situ, or ductal carcinoma in situ this year and most will undergo breast surgery as part of their care. Although prognosis is excellent, many patients experience persist ... Full text Link to item Cite

Understanding the needs and perspectives of ovarian cancer patients when considering PARP inhibitor maintenance therapy: Findings from two online community events.

Journal Article Gynecol Oncol Rep · October 2022 OBJECTIVE: The online environment is an ideal setting to understand how many women seek, receive, and understand information about cancer treatment. The purpose of this study was to understand women's needs and information-seeking around Poly ADP ribose po ... Full text Link to item Cite

Association of Transcatheter Aortic Valve Replacement Reimbursement, New Technology Add-on Payment, and Procedure Volumes With Embolic Protection Device Use.

Journal Article JAMA Cardiol · September 1, 2022 IMPORTANCE: In the setting of uncertain efficacy and additional, unreimbursed cost, use of an embolic protection device (EPD) during transcatheter aortic valve replacement (TAVR) has had variable uptake. The Centers for Medicare & Medicaid Services (CMS) i ... Full text Link to item Cite

Cost-Effectiveness of Tumor Genomic Profiling to Guide First-Line Targeted Therapy Selection in Patients With Metastatic Lung Adenocarcinoma.

Journal Article Value Health · April 2022 OBJECTIVES: A cost-effectiveness analysis comparing comprehensive genomic profiling (CGP) of 10 oncogenes, targeted gene panel testing (TGPT) of 4 oncogenes, and no tumor profiling over the lifetime for patients with metastatic lung adenocarcinoma from the ... Full text Link to item Cite

Factors associated with gene mutation testing in United States veterans with metastatic castration-resistant prostate cancer.

Conference Journal of Clinical Oncology · February 20, 2022 47 Background: Practice guidelines have been modified to recommend hereditary and tumor gene mutation testing in patients with metastatic castration-resistant prostate cancer (mCRPC) to identify patients for molecularly targeted ... Full text Cite

Economic Outcomes of Rehabilitation Therapy in Older Patients With Acute Heart Failure in the REHAB-HF Trial: A Secondary Analysis of a Randomized Clinical Trial.

Journal Article JAMA Cardiol · February 1, 2022 IMPORTANCE: In the Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial, a novel 12-week rehabilitation intervention demonstrated significant improvements in validated measures of physical function, quality of life, and depression, ... Full text Link to item Cite

Patient preferences pertaining to treatment options for drug-resistant focal epilepsy.

Journal Article Epilepsy Behav · February 2022 OBJECTIVE: To determine patient acceptability of benefit-risk trade-offs in selecting treatment options for drug-resistant mesial temporal lobe epilepsy, including open brain surgery, laser ablation (laser interstitial thermal therapy [LITT]), and continue ... Full text Link to item Cite

Lifetime cost-effectiveness simulation of once-weekly exenatide in type 2 diabetes: A cost-utility analysis based on the EXSCEL trial.

Journal Article Diabetes Res Clin Pract · January 2022 AIMS: The Exenatide Study of Cardiovascular Event Lowering (EXSCEL) trial assessed once-weekly exenatide (EQW) vs. placebo, added to usual care in 14,752 patients with type 2 diabetes mellitus (Clinicaltrials.gov: NCT01144338). We assessed the lifetime cos ... Full text Link to item Cite

Quantifying Benefit-Risk Preferences for Heart Failure Devices: A Stated-Preference Study.

Journal Article Circ Heart Fail · January 2022 BACKGROUND: Regulatory and clinical decisions involving health technologies require judgements about relative importance of their expected benefits and risks. We sought to quantify heart-failure patients' acceptance of therapeutic risks in exchange for imp ... Full text Link to item Cite

Patient Preferences for Outcomes Following DCIS Management Strategies: A Discrete Choice Experiment.

Journal Article JCO Oncol Pract · November 2021 PURPOSE: Ductal carcinoma in situ (DCIS), a nonobligate precursor of breast cancer, is often aggressively managed with multimodal therapy. However, there is limited research on patients' preferences for trade-offs among treatment-related outcomes such as b ... Full text Link to item Cite

Factors Influential in the Selection of Radiology Residents in the Post-Step 1 World: A Discrete Choice Experiment.

Journal Article J Am Coll Radiol · November 2021 OBJECTIVES: Reporting of United States Medical Licensing Examination Step 1 results will transition from a numerical score to a pass or fail result. We sought an objective analysis to determine changes in the relative importance of resident application att ... Full text Link to item Cite

Rehabilitation Intervention in Older Patients With Acute Heart Failure With Preserved Versus Reduced Ejection Fraction.

Journal Article JACC Heart Fail · October 2021 OBJECTIVES: This study assessed for treatment interactions by ejection fraction (EF) subgroup (≥45% [heart failure with preserved ejection fraction (HFpEF); vs <45% [heart failure with reduced ejection fraction (HFrEF)]). BACKGROUND: The REHAB-HF trial sho ... Full text Open Access Link to item Cite

Quantifying Value of Hope.

Journal Article Value Health · October 2021 BACKGROUND: 'Hope' is a construct in patient-centered value frameworks, but few studies have attempted to measure the value of hope separately from treatment-related gains in quality of life and survival to support its application in economic evaluation. O ... Full text Link to item Cite

The preferences of women with ovarian cancer for oral versus intravenous recurrence regimens.

Journal Article Gynecol Oncol · August 2021 OBJECTIVE: To assess preferences of women with ovarian cancer regarding features of available anti-cancer regimens for platinum-resistant, biomarker-positive disease, with an emphasis on oral PARP inhibitor and standard intravenous (IV) chemotherapy regime ... Full text Link to item Cite

Chemoradiation treatment patterns among United States Veteran Health Administration patients with unresectable stage III non-small cell lung cancer.

Journal Article BMC Cancer · July 16, 2021 BACKGROUND: The Veterans Health Administration (VHA) is the largest integrated health care system in the United States (US). Among VHA patients, the rate of use of concurrent chemoradiation therapy (CCRT) among those with unresectable, stage III non-small ... Full text Link to item Cite

Physical Rehabilitation for Older Patients Hospitalized for Heart Failure.

Journal Article The New England journal of medicine · July 2021 BackgroundOlder patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poor quality of life, delayed recovery, and frequent rehospitalizations. Interventions to address physical frailty in this pop ... Full text Cite

Impact of financial medication assistance on medication adherence: a systematic review.

Journal Article J Manag Care Spec Pharm · July 2021 BACKGROUND: The prevalence of financial medication assistance (FMA), including patient assistance programs, coupons/copayment cards, vouchers, discount cards, and programs/pharmacy services that help patients apply for such programs, has increased. The imp ... Full text Open Access Link to item Cite

A randomized feasibility pilot trial of a financial incentives intervention for dietary self-monitoring and weight loss in adults with obesity.

Journal Article Transl Behav Med · April 26, 2021 Financial incentives could be used to improve adherence to behavioral weight loss interventions, increasing their effectiveness. This Phase IIb randomized pilot study evaluated the feasibility and acceptability of a study protocol for providing financial i ... Full text Link to item Cite

Behavioral cancer pain intervention using videoconferencing and a mobile application for medically underserved patients: Rationale, design, and methods of a prospective multisite randomized controlled trial.

Journal Article Contemp Clin Trials · March 2021 BACKGROUND: Women with breast cancer in medically underserved areas are particularly vulnerable to persistent pain and disability. Behavioral pain interventions reduce pain and improve outcomes. Cancer patients in medically underserved areas receive limite ... Full text Link to item Cite

Is Easier Better Than Harder? An Experiment on Choice Experiments for Benefit-Risk Tradeoff Preferences.

Journal Article Med Decis Making · February 2021 OBJECTIVES: To test the convergent validity of simple and more complex study designs in a discrete-choice experiment (DCE) of multiple sclerosis (MS) treatment preferences. METHODS: Five hundred US adults with MS completed an online DCE survey. Respondents ... Full text Link to item Cite

EGFR mutation testing and TKI treatment patterns among veterans with stage III and IV non-small cell lung cancer.

Journal Article Cancer Treat Res Commun · 2021 BACKGROUND: Epidermal growth factor receptor (EGFR) mutation testing is recommended in metastatic non-small cell lung cancer (NSCLC). The objective of this study was to assess changes in EGFR mutation testing patterns and tyrosine kinase inhibitor (TKI) us ... Full text Link to item Cite

Health Baselines and Stated Preferences: Quantifying the Evolution of Preferences Using LCA

Conference PATIENT-PATIENT CENTERED OUTCOMES RESEARCH · 2021 Cite

Patient Preferences for Surgical Treatment of Knee Osteoarthritis: A Discrete-Choice Experiment Evaluating Total and Unicompartmental Knee Arthroplasty.

Journal Article J Bone Joint Surg Am · December 2, 2020 BACKGROUND: Total knee arthroplasty (TKA) is a common treatment for end-stage knee osteoarthritis but is associated with increased complication rates compared with unicompartmental knee arthroplasty (UKA). UKA offers better functional outcomes but is assoc ... Full text Link to item Cite

Association of 21-Gene Assay (OncotypeDX) Testing and Receipt of Chemotherapy in the Medicare Breast Cancer Patient Population Following Initial Adoption.

Journal Article Clin Breast Cancer · December 2020 BACKGROUND: Our objective was to investigate why early studies regarding adoption of the 21-gene recurrence score (RS) assay did not show an initial reduction in the number of patients with breast cancer receiving real-world chemotherapy. MATERIALS AND MET ... Full text Link to item Cite

Surgeon Applications of Patient Preferences in Treatment Decision Making for First-Time Anterior Shoulder Dislocation.

Journal Article Orthop J Sports Med · December 2020 BACKGROUND: Treatment of a first-time anterior shoulder dislocation (FTASD) is sensitive to patient preferences. The operative or nonoperative management debate provides an excellent opportunity to learn how surgeons apply patient preferences in treatment ... Full text Open Access Link to item Cite

Willingness to Accept Trade-Offs Among COVID-19 Cases, Social-Distancing Restrictions, and Economic Impact: A Nationwide US Study.

Journal Article Value Health · November 2020 OBJECTIVE: To conduct a discrete-choice experiment to quantify Americans' acceptance of severe acute respiratory syndrome coronavirus 2 infection risks for earlier lifting of social-distancing restrictions and diminishing the pandemic's economic impact. ME ... Full text Link to item Cite

Benchmarking the Cost-Effectiveness of Interventions Delaying Diabetes: A Simulation Study Based on NAVIGATOR Data.

Journal Article Diabetes Care · October 2020 OBJECTIVE: To estimate using the UK Prospective Diabetes Study Outcomes Model Version 2 (UKPDS-OM2) the impact of delaying type 2 diabetes onset on costs and quality-adjusted life expectancy using trial participants who developed diabetes in the NAVIGATOR ... Full text Link to item Cite

Patient preferences for ketamine-based antidepressant treatments in treatment-resistant depression: Results from a clinical trial and panel

Journal Article Neurology Psychiatry and Brain Research · September 1, 2020 Background: Novel ketamine-based pharmacotherapies can reduce depressive symptoms among patients with treatment-resistant depression (TRD), but associated short-term symptoms and potential adverse events raise complex benefit-risk questions. Methods: A web ... Full text Cite

Are Videos or Text Better for Describing Attributes in Stated-Preference Surveys?

Journal Article Patient · August 2020 OBJECTIVE: In stated-preference research, the conventional approach to describing study attributes is through text, often with easy-to-understand graphics. More recently, researchers have begun to present attribute descriptions and content in videos. Some ... Full text Link to item Cite

Patient Preferences Around Extent of Surgery in Low-Risk Thyroid Cancer: A Discrete Choice Experiment.

Journal Article Thyroid · July 2020 Background: Patient preferences pertaining to surgical options for thyroid cancer management are not well studied. Our aim was to conduct a discrete choice experiment (DCE) to characterize participants' views on the relative importance of various risks and ... Full text Link to item Cite

The burden of non-cardiac comorbidities and association with clinical outcomes in an acute heart failure trial - insights from ASCEND-HF.

Journal Article Eur J Heart Fail · June 2020 AIMS: Non-cardiac comorbidities are highly prevalent in patients with heart failure (HF). Our objective was to define the association between non-cardiac comorbidity burden and clinical outcomes, costs of care, and length of stay within a large randomized ... Full text Link to item Cite

Cost-Effectiveness of Alirocumab in Patients With Acute Coronary Syndromes: The ODYSSEY OUTCOMES Trial.

Journal Article J Am Coll Cardiol · May 12, 2020 BACKGROUND: Cholesterol reduction with proprotein convertase subtilisin-kexin type 9 inhibitors reduces ischemic events; however, the cost-effectiveness in statin-treated patients with recent acute coronary syndrome remains uncertain. OBJECTIVES: This stud ... Full text Link to item Cite

Cytomegalovirus in Allogeneic Hematopoietic Transplantation: Impact on Costs and Clinical Outcomes Using a Preemptive Strategy.

Journal Article Biol Blood Marrow Transplant · March 2020 Cytomegalovirus (CMV) results in significant morbidity and mortality following hematopoietic cell transplantation (HCT). Establishing the cost and clinical impact is imperative to the selection of appropriate CMV preventative strategies. This is a retrospe ... Full text Link to item Cite

Patient preferences for maintenance PARP inhibitor therapy in ovarian cancer treatment.

Journal Article Gynecol Oncol · March 2020 OBJECTIVE: To measure preferences of women with ovarian cancer regarding risks, side effects, costs and benefits afforded by maintenance therapy (MT) with a poly ADP ribose polymerase (PARP) inhibitor. METHODS: A discrete-choice experiment elicited prefere ... Full text Link to item Cite

Variation Among Patients With Crohn's Disease in Benefit vs Risk Preferences and Remission Time Equivalents.

Journal Article Clin Gastroenterol Hepatol · February 2020 BACKGROUND & AIMS: Patients with Crohn's disease (CD) must make decisions about their treatment. We aimed to quantify patients' preferences for different treatment outcomes and adverse events. We also evaluated the effects of latent class heterogeneity on ... Full text Open Access Link to item Cite

Within-Trial Evaluation of Medical Resources, Costs, and Quality of Life Among Patients With Type 2 Diabetes Participating in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL).

Journal Article Diabetes Care · February 2020 OBJECTIVE: To compare medical resource use, costs, and health utilities for 14,752 patients with type 2 diabetes who were randomized to once-weekly exenatide (EQW) or placebo in addition to usual diabetes care in the Exenatide Study of Cardiovascular Event ... Full text Link to item Cite

Patient preferences for attributes of primary surgical debulking versus neoadjuvant chemotherapy for treatment of newly diagnosed ovarian cancer.

Journal Article Cancer · December 15, 2019 BACKGROUND: Randomized trials have reported conflicting findings on survival for advanced-stage ovarian cancer treated with primary debulking surgery (PDS) versus neoadjuvant chemotherapy with interval debulking; surgical complications and mortality are hi ... Full text Link to item Cite

Patients' Willingness to Accept Mitral Valve Procedure-Associated Risks Varies Across Severity of Heart Failure Symptoms.

Journal Article Circ Cardiovasc Interv · December 2019 BACKGROUND: The Food and Drug Administration's Center for Drugs and Radiological Health issued Guidance in 2016 on generating patient preference information to aid evaluation of medical devices. Consistent with this guidance, we aimed to provide quantitati ... Full text Link to item Cite

Ninety-day and one-year healthcare utilization and costs after knee arthroplasty.

Journal Article Osteoarthritis Cartilage · October 2019 OBJECTIVES: This study examined ninety-day and one-year postoperative healthcare utilization and costs following total knee arthroplasty (TKA) from the health sector and patient perspectives. DESIGN: This study relied on: 1) patient-reported medical resour ... Full text Link to item Cite

An NLP tool to identify molecular diagnostic testing in veterans with stage IV NSCLC.

Conference Journal of Clinical Oncology · September 20, 2019 318 Background: ASCO Quality Oncology Practice Initiative (QOPI) encourages hospitals to determine if patients (pts) with stage IV NSCLC adenocarcinoma have activating EGFR mutations. Guidelines recommend tumor testing to identif ... Full text Cite

Something Is Better Than Nothing: The Value of Active Intervention in Stated Preferences for Treatments to Delay Onset of Alzheimer's Disease Symptoms.

Journal Article Value Health · September 2019 BACKGROUND: The objective of the study was to understand respondents' willingness to accept hypothetical treatment-related risks in return for the benefit of additional time with normal memory from potential Alzheimer's disease interception therapies. METH ... Full text Link to item Cite

Changes in Serum Calcitonin Concentrations, Incidence of Medullary Thyroid Carcinoma, and Impact of Routine Calcitonin Concentration Monitoring in the EXenatide Study of Cardiovascular Event Lowering (EXSCEL).

Journal Article Diabetes Care · June 2019 OBJECTIVE: Increases in serum calcitonin, a tumor marker for medullary thyroid carcinoma (MTC), have been associated with glucagon-like peptide 1 receptor agonist use in some preclinical studies. We report calcitonin changes in exenatide-treated and placeb ... Full text Link to item Cite

Comparing the Noncomparable: The Need for Equivalence Measures That Make Sense in Health-Economic Evaluations.

Journal Article Value Health · June 2019 BACKGROUND: The popularity of quality-adjusted life years (QALYs) has been resistant to concerns about validity and reliability. Utility-theoretic outcome equivalents are widely used in other areas of applied economics. Equivalence values can be derived fo ... Full text Link to item Cite

Patient preferences for maintenance PARP therapy in ovarian cancer treatment.

Conference Journal of Clinical Oncology · May 20, 2019 5558 Background: Maintenance therapy with PARP inhibitors has become prevalent in treating ovarian cancer. However, the preferences of women with ovarian cancer regarding the risks, side effects and benefits afforded by maintenan ... Full text Cite

Improved Quality of Life With Anti-TNF Therapy Compared With Continued Corticosteroid Utilization in Crohn's Disease.

Journal Article Inflamm Bowel Dis · April 11, 2019 BACKGROUND: Corticosteroids (CS) and anti-TNF drugs are used to treat Crohn's disease (CD). In this study, we assessed the net health benefit of initiating anti-TNF therapy relative to additional CS use in CD using a novel combination of a retrospective co ... Full text Link to item Cite

Chemotherapy Costs and 21-Gene Recurrence Score Genomic Testing Among Medicare Beneficiaries With Early-Stage Breast Cancer, 2005 to 2011.

Journal Article J Natl Compr Canc Netw · March 1, 2019 BACKGROUND: This study examined whether associations between 21-gene recurrence score (RS) genomic testing and lower costs among patients with early-stage, estrogen receptor-positive breast cancer are observable in real-world data from the Medicare populat ... Full text Link to item Cite

Log2Lose: Development and Lessons Learned From a Mobile Technology Weight Loss Intervention.

Journal Article JMIR Mhealth Uhealth · February 13, 2019 BACKGROUND: Providing financial incentives has gained popularity as a strategy to promote weight loss, but questions remain about how best to utilize them. A promising mobile health strategy provides users with near-real-time financial incentives based on ... Full text Link to item Cite

Pain Coping Skills Training for Patients Who Catastrophize About Pain Prior to Knee Arthroplasty: A Multisite Randomized Clinical Trial.

Journal Article J Bone Joint Surg Am · February 6, 2019 BACKGROUND: Pain catastrophizing has been identified as a prognostic indicator of poor outcome following knee arthroplasty. Interventions to address pain catastrophizing, to our knowledge, have not been tested in patients undergoing knee arthroplasty. The ... Full text Link to item Cite

The Internal Validity of Discrete Choice Experiment Data: A Testing Tool for Quantitative Assessments.

Journal Article Value Health · February 2019 OBJECTIVES: To develop a tool for testing internal validity of discrete choice experiment (DCE) data, deploy the program, and collect summary test results from a sample of active health researchers to demonstrate the practical utility of the tool in a wide ... Full text Link to item Cite

Relationship between changing patient-reported outcomes and subsequent clinical events in patients with chronic heart failure: insights from HF-ACTION.

Journal Article Eur J Heart Fail · January 2019 AIMS: A 5-point change in the Kansas City Cardiomyopathy Questionnaire (KCCQ) is commonly considered to be a clinically significant difference in health status in patients with heart failure. We evaluated how the magnitude of change relates to subsequent c ... Full text Link to item Cite

INITIAL ADOPTION OF RECOMBINANT HUMAN THYROID-STIMULATING HORMONE FOLLOWING THYROIDECTOMY IN THE MEDICARE THYROID CANCER PATIENT POPULATION.

Journal Article Endocr Pract · January 2019 OBJECTIVE: Recombinant human thyroid-stimulating hormone (rhTSH) has been approved for diagnostic (1998) and therapeutic (2008) indications in conjunction with radioactive iodine (RAI) administration post-thyroidectomy. Potential benefits of rhTSH, includi ... Full text Link to item Cite

Testing a behavioral intervention to improve adherence to adjuvant endocrine therapy (AET).

Journal Article Contemp Clin Trials · January 2019 Adjuvant endocrine therapy (AET) is used to prevent recurrence and reduce mortality for women with hormone receptor positive breast cancer. Poor adherence to AET is a significant problem and contributes to increased medical costs and mortality. A variety o ... Full text Open Access Link to item Cite

Preferences of women with epithelial ovarian cancer for aspects of genetic testing.

Journal Article Gynecol Oncol Res Pract · 2019 BACKGROUND: Although genetic testing is recommended for women with epithelial ovarian cancer (EOC), little is known about patient preferences for various testing options. We measured relative preferences for attributes of testing in women with EOC referred ... Full text Link to item Cite

Use of clinical algorithms and rapid influenza testing to manage influenza-like illness: a cost-effectiveness analysis in Sri Lanka.

Journal Article BMJ Glob Health · 2019 BACKGROUND: Acute respiratory infections are a common reason for antibiotic overuse. We previously showed that providing Sri Lankan clinicians with positive rapid influenza test results was associated with a reduction in antibiotic prescriptions. The econo ... Full text Link to item Cite

Sex differences in management and outcomes of patients with type 2 diabetes and cardiovascular disease: A report from TECOS.

Journal Article Diabetes Obes Metab · October 2018 AIM: To examine sex differences in baseline characteristics and outcomes in patients with type 2 diabetes and atherosclerotic vascular disease. MATERIALS AND METHODS: Cox models were used to analyse the association between sex and outcomes in the Trial Eva ... Full text Link to item Cite

Effective Partnering in Conducting Benefit-Risk Patient Preference Studies: Perspectives From a Patient Advocacy Organization, a Pharmaceutical Company, and Academic Stated-Preference Researchers.

Journal Article Ther Innov Regul Sci · July 2018 BACKGROUND: Formal incorporation of patients' perspectives is becoming increasingly important in medical product development and decision making. This article shares practical advice regarding how patient advocacy organizations, the pharmaceutical industry ... Full text Link to item Cite

Longitudinal medical resources and costs among type 2 diabetes patients participating in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS).

Journal Article Diabetes Obes Metab · July 2018 AIMS: TECOS, a cardiovascular safety trial (ClinicalTrials.gov identifier: NCT00790205) involving 14 671 patients with type 2 diabetes and cardiovascular disease, demonstrated that sitagliptin was non-inferior to placebo for the primary composite cardiovas ... Full text Link to item Cite

EXSCEL—Once-Weekly Exenatide Reduces Medical Resource Utilization in Patients with Type 2 Diabetes Mellitus

Conference Diabetes · July 1, 2018 Objectives: To evaluate the effect of exenatide 2mg once-weekly vs. placebo in addition to usual care on medical resource use among 14,572 patients with type 2 diabetes enrolled in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL), whic ... Full text Cite

Study protocol for Log2Lose: A feasibility randomized controlled trial to evaluate financial incentives for dietary self-monitoring and interim weight loss in adults with obesity.

Journal Article Contemp Clin Trials · February 2018 The obesity epidemic has negative physical, psychological, and financial consequences. Despite the existence of effective behavioral weight loss interventions, many individuals do not achieve adequate weight loss, and most regain lost weight in the year fo ... Full text Link to item Cite

What is clearance worth? Patients' stated risk tolerance for psoriasis treatments.

Journal Article J Dermatolog Treat · December 2017 PURPOSE: The purpose of this study was to provide quantitative evidence of patients' tolerance for therapeutic risks associated with psoriasis treatments that could offer psoriasis improvements beyond the PASI 75 benchmark. MATERIALS AND METHODS: We used a ... Full text Link to item Cite

Depression, quality of life, and medical resource utilization in sickle cell disease.

Journal Article Blood Adv · October 24, 2017 Sickle cell disease (SCD) is a chronic, debilitating disorder. Chronically ill patients are at risk for depression, which can affect health-related quality of life (HRQoL), health care utilization, and cost. We performed an analytic epidemiologic prospecti ... Full text Open Access Link to item Cite

The economics of PCSK-9 inhibitors.

Journal Article Am Heart J · July 2017 Full text Link to item Cite

Optimizing delivery of a behavioral pain intervention in cancer patients using a sequential multiple assignment randomized trial SMART.

Journal Article Contemp Clin Trials · June 2017 BACKGROUND/AIMS: Pain is common in cancer patients and results in lower quality of life, depression, poor physical functioning, financial difficulty, and decreased survival time. Behavioral pain interventions are effective and nonpharmacologic. Traditional ... Full text Link to item Cite

Testing a behavioral intervention to improve adherence to adjuvant endocrine therapy (AET).

Conference Journal of Clinical Oncology · May 20, 2017 TPS10128 Background: Adjuvant endocrine therapy (AET) is a crucial component of treatment used to prevent recurrence and reduce mortality for women with hormone receptor positive breast cancer. Poor adherence to AET is a signific ... Full text Cite

Increased Costs Associated with Bloodstream Infections Caused by Multidrug-Resistant Gram-Negative Bacteria Are Due Primarily to Patients with Hospital-Acquired Infections.

Journal Article Antimicrob Agents Chemother · March 2017 The clinical and economic impacts of bloodstream infections (BSI) due to multidrug-resistant (MDR) Gram-negative bacteria are incompletely understood. From 2009 to 2015, all adult inpatients with Gram-negative BSI at our institution were prospectively enro ... Full text Open Access Link to item Cite

Does the Implantable Cardioverter-Defibrillator Benefit Vary With the Estimated Proportional Risk of Sudden Death in Heart Failure Patients?

Journal Article JACC Clin Electrophysiol · March 2017 BACKGROUND: Prediction of which heart failure patients are most likely to die of sudden death vs. non-sudden death is an important factor in determining who will benefit the most from an ICD. OBJECTIVE: We developed the Seattle Proportional Risk Model (SPR ... Full text Link to item Cite

Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial: Design and rationale.

Journal Article Am Heart J · March 2017 BACKGROUND: Acute decompensated heart failure (ADHF) is a leading cause of hospitalization in older persons in the United States. Reduced physical function and frailty are major determinants of adverse outcomes in older patients with hospitalized ADHF. How ... Full text Link to item Cite

Understanding Preferences for Treatment After Hypothetical First-Time Anterior Shoulder Dislocation: Surveying an Online Panel Utilizing a Novel Shared Decision-Making Tool.

Journal Article Orthop J Sports Med · March 2017 BACKGROUND: Although surgical management of a first-time anterior shoulder dislocation (FTASD) can reduce the risk of recurrent dislocation, other treatment characteristics, costs, and outcomes are important to patients considering treatment options. While ... Full text Open Access Link to item Cite

Is There a Minimum Number of Thyroidectomies a Surgeon Should Perform to Optimize Patient Outcomes?

Journal Article Ann Surg · February 2017 OBJECTIVE: To determine the number of total thyroidectomies per surgeon per year associated with the lowest risk of complications. BACKGROUND: The surgeon volume-outcome association has been established for thyroidectomy; however, a threshold number of cas ... Full text Link to item Cite

Cost Comparison of Genetic Testing Strategies in Women With Epithelial Ovarian Cancer.

Journal Article J Oncol Pract · February 2017 PURPOSE: The advent of multigene panels has increased genetic testing options for women with epithelial ovarian cancer (EOC). We designed a decision model to compare costs and probabilities of identifying a deleterious mutation or variant of uncertain sign ... Full text Link to item Cite

Developing the Value Proposition for Personalized Medicine

Chapter · January 1, 2017 Standard methodological approaches have successfully been applied to evaluate the cost-effectiveness of numerous personalized medicine tests, particularly for companion diagnostics developed in the context of a clinical trial. However, disagreement has eme ... Full text Cite

Patient Preferences for Features of Health Care Delivery Systems: A Discrete Choice Experiment.

Journal Article Health Serv Res · April 2016 OBJECTIVE: To estimate the relative importance of organizational-, procedural-, and interpersonal-level features of health care delivery systems from the patient perspective. DATA SOURCES/STUDY SETTING: We designed four discrete choice experiments (DCEs) t ... Full text Link to item Cite

Relation of Elevated Heart Rate in Patients With Heart Failure With Reduced Ejection Fraction to One-Year Outcomes and Costs.

Journal Article Am J Cardiol · March 15, 2016 There are limited data describing outcomes associated with an elevated heart rate in patients with heart failure with reduced ejection fraction (HFrEF) in routine clinical practice. We identified patients with HFrEF at Duke University Hospital undergoing e ... Full text Link to item Cite

Is There a Minimum Number of Thyroidectomies a Surgeon Should Perform to Optimize Patient Outcomes?

Journal Article Ann Surg · March 8, 2016 : Supplemental Digital Content is available in the text OBJECTIVE:: To determine the number of total thyroidectomies per surgeon per year associated with the lowest risk of complications. BACKGROUND: The surgeon volume-outcome association has been establis ... Full text Link to item Cite

The clinical course of health status and association with outcomes in patients hospitalized for heart failure: insights from ASCEND-HF.

Journal Article Eur J Heart Fail · March 2016 AIMS: A longitudinal and comprehensive analysis of health-related quality of life (HRQOL) was performed during hospitalization for heart failure (HF) or soon after discharge. METHODS AND RESULTS: A post-hoc analysis was performed of the ASCEND-HF trial. Th ... Full text Link to item Cite

Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients.

Journal Article Ann Am Thorac Soc · March 2016 RATIONALE: Limitations in methods for the rapid diagnosis of hospital-acquired infections often delay initiation of effective antimicrobial therapy. New diagnostic approaches offer potential clinical and cost-related improvements in the management of these ... Full text Open Access Link to item Cite

Chemotherapy costs associated with receipt of the adoption of oncotype DX in early-stage breast cancer within the SEER-Medicare population.

Conference Journal of Clinical Oncology · March 1, 2016 32 Background: The Oncotype DX (ODX) multigene assay has been previously suggested to result in an overall reduction in the use of adjuvant chemotherapy and associated costs for women with early stage, estrogen receptor (ER)-posi ... Full text Cite

Resource Use in the Last Year of Life Among Patients Who Died With Versus of Prostate Cancer.

Journal Article Clin Genitourin Cancer · February 2016 UNLABELLED: We conducted a retrospective analysis of Surveillance, Epidemiology, and End Results-Medicare data of men with prostate cancer. Among 34,727 patients, those who died of their prostate cancer had more hospice and outpatient use, less inpatient a ... Full text Link to item Cite

Out-of-Pocket Spending for Ambulatory Physical Therapy Services From 2008 to 2012: National Panel Survey.

Journal Article Phys Ther · December 2015 BACKGROUND: Out-of-pocket (OOP) expenditures are incurred as insurers and employers shift some of the burden of health care costs onto consumers. As cost-sharing increases, OOP expenditures could be a barrier to physical therapy care. OBJECTIVE: The purpos ... Full text Link to item Cite

A Bedside Risk Calculator to Preoperatively Distinguish Follicular Thyroid Carcinoma from Follicular Variant of Papillary Thyroid Carcinoma.

Journal Article World J Surg · December 2015 BACKGROUND: Follicular thyroid carcinoma (FTC) and follicular variant of papillary thyroid carcinoma (FV-PTC) are difficult entities to distinguish based on cytology prior to pathologic evaluation of surgical specimens but may have different treatment algo ... Full text Link to item Cite

Longitudinal Trends in Costs of Palliative Radiation for Metastatic Prostate Cancer.

Conference J Palliat Med · November 2015 BACKGROUND: In recent years, palliative treatment of prostate cancer metastases has been characterized by the use of more complex radiation treatment, despite a lack of evidence demonstrating a clinical benefit of these technologies in the palliative setti ... Full text Link to item Cite

Association Between Use of the 21-Gene Recurrence Score Assay and Receipt of Chemotherapy Among Medicare Beneficiaries With Early-Stage Breast Cancer, 2005-2009.

Journal Article JAMA Oncol · November 2015 IMPORTANCE: Guidelines recommend consideration of chemotherapy for most patients with early-stage, estrogen receptor-positive, invasive breast cancer in the absence of additional prognostic information. The 21-gene recurrence score (RS) assay has been show ... Full text Link to item Cite

Tools for Economic Analysis of Patient Management Interventions in Heart Failure Cost-Effectiveness Model: A Web-based program designed to evaluate the cost-effectiveness of disease management programs in heart failure.

Journal Article Am Heart J · November 2015 Featured Publication BACKGROUND: Heart failure disease management programs can influence medical resource use and quality-adjusted survival. Because projecting long-term costs and survival is challenging, a consistent and valid approach to extrapolating short-term outcomes wou ... Full text Link to item Cite

Minimally Invasive Distal Pancreatectomy for Cancer: Short-Term Oncologic Outcomes in 1,733 Patients.

Journal Article World J Surg · October 2015 BACKGROUND: Data from high-volume institutions suggest that minimally invasive distal pancreatectomy (MIDP) provides favorable perioperative outcomes and adequate oncologic resection for pancreatic cancer; however, these outcomes may not be generalizable. ... Full text Link to item Cite

Incremental and independent value of cardiopulmonary exercise test measures and the Seattle Heart Failure Model for prediction of risk in patients with heart failure.

Journal Article J Heart Lung Transplant · August 2015 BACKGROUND: Multivariable risk scores and exercise measures are well-validated risk prediction methods. Combining information from a functional evaluation and a risk model may improve accuracy of risk predictions. We analyzed whether adding exercise measur ... Full text Link to item Cite

Minimally Invasive Versus Open Pancreaticoduodenectomy for Cancer: Practice Patterns and Short-term Outcomes Among 7061 Patients.

Journal Article Ann Surg · August 2015 OBJECTIVES: To describe national practice patterns regarding utilization of minimally invasive pancreaticoduodenectomy (MIPD) and compare short-term outcomes with those following open pancreaticoduodenectomy for cancer. BACKGROUND: There is increasing inte ... Full text Link to item Cite

Presence and Number of Lymph Node Metastases Are Associated With Compromised Survival for Patients Younger Than Age 45 Years With Papillary Thyroid Cancer.

Journal Article J Clin Oncol · July 20, 2015 PURPOSE: Cervical lymph node metastases are recognized as a prognostic indicator only in patients age 45 years or older with papillary thyroid cancer (PTC); patients younger than age 45 years are perceived to have low-risk disease. The current American Joi ... Full text Link to item Cite

Initial Trends in the Use of the 21-Gene Recurrence Score Assay for Patients With Breast Cancer in the Medicare Population, 2005-2009.

Journal Article JAMA Oncol · May 2015 IMPORTANCE: In 2006, the Centers for Medicare & Medicaid Services approved coverage for the use of the 21-gene recurrence score (RS) assay in women with early-stage, estrogen receptor-positive, node-negative breast cancers to help guide recommendations for ... Full text Link to item Cite

Cost-effectiveness analysis alongside clinical trials II-An ISPOR Good Research Practices Task Force report.

Journal Article Value Health · March 2015 Clinical trials evaluating medicines, medical devices, and procedures now commonly assess the economic value of these interventions. The growing number of prospective clinical/economic trials reflects both widespread interest in economic information for ne ... Full text Link to item Cite

Impact of extent of surgery on survival for papillary thyroid cancer patients younger than 45 years.

Journal Article J Clin Endocrinol Metab · January 2015 CONTEXT: Papillary thyroid cancer (PTC) patients <45 years old are considered to have an excellent prognosis; however, current guidelines recommend total thyroidectomy for PTC tumors >1.0 cm, regardless of age. OBJECTIVE: Our objective was to examine the i ... Full text Link to item Cite

Implementing Lung Cancer Screening Using Low-Dose Computed Tomography: Recommendations From an Expert Panel.

Journal Article J Oncol Pract · January 2015 PURPOSE: In December 2013, the US Preventive Services Task Force issued a final B-level recommendation indicating that individuals between the ages of 55 and 80 years who have a 30-pack-year smoking history and have smoked within the past 15 years should r ... Full text Link to item Cite

Staphylococcus aureus infections following knee and hip prosthesis insertion procedures.

Journal Article Antimicrob Resist Infect Control · 2015 BACKGROUND: Staphylococcus aureus is the most common and most important pathogen following knee and hip arthroplasty procedures. Understanding the epidemiology of invasive S. aureus infections is important to quantify this serious complication. METHODS: Th ... Full text Link to item Cite

Impact of extent of surgery on survival for papillary thyroid cancer patients younger than 45 years

Journal Article Journal of Clinical Endocrinology and Metabolism · 2015 © 2015 by the Endocrine Society.Context: Papillary thyroid cancer (PTC) patients <45 years old are considered to have an excellent prognosis; however, current guidelines recommend total thyroidectomy for PTC tumors 1.0 cm, regardless of age. Objective: ... Full text Cite

Patient preferences in advanced or recurrent ovarian cancer.

Journal Article Cancer · December 1, 2014 BACKGROUND: The objective of this study was to elucidate relative preferences of women with ovarian cancer for symptoms, treatment-related side effects, and progression-free survival (PFS) relevant to choosing a treatment regimen. METHODS: Women with advan ... Full text Link to item Cite

Robotic thyroidectomy for cancer in the US: patterns of use and short-term outcomes.

Journal Article Ann Surg Oncol · November 2014 BACKGROUND: We describe nationally representative patterns of utilization and short-term outcomes from robotic versus open thyroidectomy for thyroid cancer. METHODS: Descriptive statistics and multivariable analysis were used to analyze patterns of use of ... Full text Link to item Cite

Impact of extent of surgery on survival in patients with small nonfunctional pancreatic neuroendocrine tumors in the United States.

Journal Article Ann Surg Oncol · October 2014 BACKGROUND: Nonfunctional pancreatic neuroendocrine tumors (PNETs) ≤2 cm have uncertain malignant potential, and optimal treatment remains unclear. Objectives of this study were to better understand their malignant potential, determine whether extent of su ... Full text Link to item Cite

Treatment patterns and outcomes for patients with adrenocortical carcinoma associated with hospital case volume in the United States.

Journal Article Ann Surg Oncol · October 2014 BACKGROUND: Adrenocortical carcinoma (ACC) is a rare, aggressive disease with no apparent change in treatment or survival in the United States over the past two decades. Our objective was to determine whether treatment patterns or clinical outcomes vary by ... Full text Link to item Cite

Extent of surgery for papillary thyroid cancer is not associated with survival: an analysis of 61,775 patients.

Journal Article Ann Surg · October 2014 OBJECTIVE: To examine the association between the extent of surgery and overall survival in a large contemporary cohort of patients with papillary thyroid cancer (PTC). BACKGROUND: Guidelines recommend total thyroidectomy for PTC tumors >1 cm, based on old ... Full text Link to item Cite

Nurse practitioners can effectively deliver pain coping skills training to osteoarthritis patients with chronic pain: A randomized, controlled trial.

Journal Article Pain · September 2014 A multisite, randomized, controlled clinical effectiveness trial was conducted for osteoarthritis patients with chronic pain of the knee or hip. Adult health nurse practitioners provided a 10-session intervention, pain coping skills training (PCST), in pat ... Full text Link to item Cite

Pilot study of pharmacist-assisted delivery of pharmacogenetic testing in a primary care setting.

Journal Article Pharmacogenomics · September 2014 AIM: To describe the rationale and design of a pilot program to implement and evaluate pharmacogenetic (PGx) testing in a primary care setting. STUDY RATIONALE: Several factors have impeded the uptake of PGx testing, including lack of provider knowledge an ... Full text Link to item Cite

Can delaying the onset of type 2 diabetes be cost-effective?

Journal Article DIABETOLOGIA · September 1, 2014 Link to item Cite

Associations between seattle heart failure model scores and medical resource use and costs: findings from HF-ACTION.

Journal Article J Card Fail · August 2014 BACKGROUND: Prognostic models, such as the Seattle Heart Failure Model (SHFM), have been developed to predict patient survival. The extent to which they predict medical resource use and costs has not been explored. In this study, we evaluated relationships ... Full text Link to item Cite

Statistical considerations in economic evaluations: a guide for cardiologists.

Journal Article Eur Heart J · July 1, 2014 The author reviews statistical methods commonly applied in economic evaluations that rely on individual patient-level data. The paper includes a review of foundational concepts, unique characteristics of health economic data, and methods developed to addre ... Full text Link to item Cite

A framework to evaluate the cost-effectiveness of the NADiA ProsVue slope to guide adjuvant radiotherapy among men with high-risk characteristics following prostatectomy for prostate cancer.

Journal Article Value Health · July 2014 OBJECTIVES: The NADiA ProsVue is a prognostic system that measures prostate-specific antigen slope to identify men at lower risk of clinical recurrence of prostate cancer after radical prostatectomy. We developed a decision-modeling framework to evaluate i ... Full text Link to item Cite

Impact of cardiovascular events on change in quality of life and utilities in patients after myocardial infarction: a VALIANT study (valsartan in acute myocardial infarction).

Journal Article JACC Heart Fail · April 2014 OBJECTIVES: The objective of this study was to determine the impact of nonfatal cardiovascular (CV) events on changes in health-related quality of life (HRQL). BACKGROUND: There is limited understanding of the impact of nonfatal CV events on long-term chan ... Full text Link to item Cite

Differences in treatment, outcomes, and quality of life among patients with heart failure in Canada and the United States.

Journal Article JACC Heart Fail · December 2013 OBJECTIVES: The aim of this study was to compare clinical outcomes, resource utilization, and health-related quality of life between Canadian and U.S. patients enrolled in ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Hear ... Full text Link to item Cite

Medical resource use, costs, and quality of life in patients with acute decompensated heart failure: findings from ASCEND-HF.

Journal Article J Card Fail · September 2013 BACKGROUND: The Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF) randomly assigned 7,141 participants to nesiritide or placebo. Dyspnea improvement was more often reported in the nesiritide group, but there wer ... Full text Link to item Cite

Do countries or hospitals with longer hospital stays for acute heart failure have lower readmission rates?: Findings from ASCEND-HF.

Journal Article Circ Heart Fail · July 2013 BACKGROUND: Hospital readmission is an important clinical outcome of patients with heart failure. Its relation to length of stay for the initial hospitalization is not clear. METHODS AND RESULTS: We used hierarchical modeling of data from a clinical trial ... Full text Link to item Cite

Oncology comparative effectiveness research: a multistakeholder perspective on principles for conduct and reporting.

Journal Article Oncologist · June 2013 Comparative effectiveness research (CER) can assist patients, clinicians, purchasers, and policy makers in making more informed decisions that will improve cancer care and outcomes. Despite its promise, the factors that distinguish CER from other types of ... Full text Link to item Cite

Defining a clinically meaningful effect for the design and interpretation of randomized controlled trials

Journal Article Innovations in Clinical Neuroscience · May 1, 2013 Objective: This article captures the proceedings of a meeting aimed at defining clinically meaningful effects for use in randomized controlled trials for psychopharmacological agents. Design: Experts from a variety of disciplines defined clinically meaning ... Cite

Associations between Seattle Heart Failure Model scores and health utilities: findings from HF-ACTION.

Journal Article J Card Fail · May 2013 BACKGROUND: The Seattle Heart Failure Model (SHFM) is a well validated prediction model of all-cause mortality in patients with heart failure, but its relationship with generic health status measures has not been evaluated. We sought to investigate relatio ... Full text Link to item Cite

Defining a clinically meaningful effect for the design and interpretation of randomized controlled trials.

Journal Article Innov Clin Neurosci · May 2013 OBJECTIVE: This article captures the proceedings of a meeting aimed at defining clinically meaningful effects for use in randomized controlled trials for psychopharmacological agents. DESIGN: Experts from a variety of disciplines defined clinically meaning ... Link to item Cite

Cost-effectiveness of the 21-gene recurrence score assay in the context of multifactorial decision making to guide chemotherapy for early-stage breast cancer.

Journal Article Genet Med · March 2013 PURPOSE: New evidence is available regarding the utility of the 21-gene recurrence score assay in guiding chemotherapy use for node-negative, estrogen receptor-positive breast cancer. We applied this evidence in a decision-analytic model to re-evaluate the ... Full text Link to item Cite

Update on the role of epothilones in metastatic breast cancer

Journal Article Current Breast Cancer Reports · March 1, 2013 The role of epothilones in the treatment of locally advanced and metastatic breast cancer remains unclear. While the pivotal studies for ixabepilone were published between 2005 and 2010, and the agent received approval in 2007 from the U.S. Food and Drug A ... Full text Cite

Comparative effectiveness of nonbiologic versus biologic disease-modifying antirheumatic drugs for rheumatoid arthritis.

Journal Article J Rheumatol · February 2013 OBJECTIVE: To evaluate the comparative effectiveness of nonbiologic disease-modifying antirheumatic drugs (DMARD) versus biologic DMARD (bDMARD) for treatment of rheumatoid arthritis (RA), using 2 common analytic approaches. METHODS: We analyzed change in ... Full text Link to item Cite

Patient time costs associated with sensor-augmented insulin pump therapy for type 1 diabetes: results from the STAR 3 randomized trial.

Journal Article Med Decis Making · February 2013 BACKGROUND: Sensor-augmented pump therapy (SAPT) leads to lower glycated hemoglobin levels than multiple daily injections of insulin (MDI) in patients with type 1 diabetes. Patient time and costs associated with SAPT are not known. OBJECTIVE: We compared t ... Full text Link to item Cite

Does variation in either age at start of therapy or duration of therapy make chemoprevention with finasteride cost-effective?

Journal Article Prostate Cancer Prostatic Dis · December 2012 BACKGROUND: Incremental cost-effectiveness ratios (ICERs) of finasteride for prostate cancer prevention are consistent with estimates beyond $100 000 per quality-adjusted life-year (QALY). The majority of these analyses are based on chemoprevention startin ... Full text Link to item Cite

Proposed 'grant-and-access' program with price caps could stimulate development of drugs for very rare diseases.

Journal Article Health Aff (Millwood) · November 2012 The 1983 Orphan Drug Act created incentives for the development of orphan drugs. Despite its successes, including a substantial increase in new drugs, approved orphan drugs still treat fewer than 5 percent of registered rare diseases. In addition, concerns ... Full text Link to item Cite

In-hospital resource use and medical costs in the last year of life by mode of death (from the HF-ACTION randomized controlled trial).

Journal Article Am J Cardiol · October 15, 2012 Patterns of medical resource use near the end of life may differ across modes of death. The aim of this study was to characterize patterns of inpatient resource use and direct costs for patients with heart failure (HF) who died of sudden cardiac death (SCD ... Full text Link to item Cite

Associations between hemoglobin level, resource use, and medical costs in patients with heart failure: findings from HF-ACTION.

Journal Article J Card Fail · October 2012 BACKGROUND: Reports that patients with heart failure and anemia incur greater costs and medical resource use have relied largely on data with limited clinical detail. METHODS: HF-ACTION, a large trial of exercise training in heart failure, recorded hemoglo ... Full text Link to item Cite

A phase III randomized three-arm trial of physical therapist delivered pain coping skills training for patients with total knee arthroplasty: the KASTPain protocol.

Journal Article BMC Musculoskelet Disord · August 20, 2012 BACKGROUND: Approximately 20% of patients report persistent and disabling pain following total knee arthroplasty (TKA) despite an apparently normally functioning prosthesis. One potential risk factor for unexplained persistent pain is high levels of pain c ... Full text Link to item Cite

Changes in initial treatment for prostate cancer among Medicare beneficiaries, 1999-2007.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 PURPOSE: In the absence of evidence from large clinical trials, optimal therapy for localized prostate cancer remains unclear; however, treatment patterns continue to change. We examined changes in the management of patients with prostate cancer in the Med ... Full text Link to item Cite

Pharmacoeconomics: Economic Evaluation of Pharmaceuticals

Journal Article · January 3, 2012 Ongoing concerns about the costs of medical care have led both purchasers and producers of pharmaceuticals to realize that the cost of drugs is not limited to their purchase price. Accompanying costs of preparation, administration, monitoring for and treat ... Full text Cite

Resource use, costs, and utility estimates for patients with cystic fibrosis with mild impairment in lung function: analysis of data collected alongside a 48-week multicenter clinical trial.

Journal Article Value Health · 2012 Featured Publication OBJECTIVES: Transport of ions to generate epithelial rehydration (TIGER)-1 was a randomized trial conducted to evaluate the safety and efficacy of denufosol versus placebo in patients with cystic fibrosis with mild impairment in lung function. The trial me ... Full text Link to item Cite

Cost-effectiveness of truncated therapy for hepatitis C based on rapid virologic response.

Journal Article Value Health · 2012 BACKGROUND: Shortened courses of treatment with pegylated interferon alfa and ribavirin for patients with hepatitis C virus infection who experience rapid virologic response can be effective in appropriately selected patients. The cost-effectiveness of tru ... Full text Link to item Cite

Introduction of the Tools for Economic Analysis of Patient Management Interventions in Heart Failure Costing Tool: a user-friendly spreadsheet program to estimate costs of providing patient-centered interventions.

Journal Article Circ Cardiovasc Qual Outcomes · January 2012 Featured Publication BACKGROUND: Patient-centered health care interventions, such as heart failure disease management programs, are under increasing pressure to demonstrate good value. Variability in costing methods and assumptions in economic evaluations of such interventions ... Full text Link to item Cite

Economic evaluation of direct-acting antiviral therapy in chronic hepatitis C.

Journal Article Antivir Ther · 2012 In 2011, the protease inhibitors boceprevir and telaprevir were approved in the United States and European Union for the treatment of hepatitis C infection. While remarkably effective, the newly approved therapies are also accompanied by additional side ef ... Full text Link to item Cite

Cost-effectiveness of sensor-augmented pump therapy in adults with type 1 diabetes in the United States.

Journal Article Value Health · 2012 OBJECTIVES: A recent randomized trial demonstrated significant reductions in hemoglobin A(1c) levels with sensor-augmented pump therapy (SAPT) compared with multiple daily injections of insulin (MDI) in type 1 diabetes. We analyzed resource use in the tria ... Full text Link to item Cite

End point selection in acute decompensated heart failure clinical trials: economic end points.

Journal Article Heart Fail Clin · October 2011 Featured Publication The selection of economic end points in acute decompensated heart failure (ADHF) clinical trials requires prospectively planned evaluations that are developed in tandem with clinical end points. Integrating economic end points with concrete clinical outcom ... Full text Link to item Cite

Comparative effectiveness research in lung diseases and sleep disorders: recommendations from the National Heart, Lung, and Blood Institute workshop.

Journal Article Am J Respir Crit Care Med · October 1, 2011 The Division of Lung Diseases of the National Heart, Lung, and Blood Institute (NHLBI) held a workshop to develop recommendations on topics, methodologies, and resources for comparative effectiveness research (CER) that will guide clinical decision making ... Full text Link to item Cite

Resource Use and Medical Costs by Cause of Death in HF-ACTION

Journal Article Journal of Cardiac Failure · August 2011 Full text Cite

Financial implications of changes in the initial treatment of prostate cancer among Medicare beneficiaries.

Journal Article J Clin Oncol · May 20, 2011 6115 Background: The traditional treament approaches for localized prostate cancer have included androgen suppression, watchful waiting, open radical prostatectomy, external beam radiation therapy and interstitial brachytherapy. In the last decade a number ... Link to item Cite

Do heart failure disease management programs make financial sense under a bundled payment system?

Journal Article Am Heart J · May 2011 BACKGROUND: Policy makers have proposed bundling payments for all heart failure (HF) care within 30 days of an HF hospitalization in an effort to reduce costs. Disease management (DM) programs can reduce costly HF readmissions but have not been economicall ... Full text Link to item Cite

Effects of family history and genetic polymorphism on the cost-effectiveness of chemoprevention with finasteride for prostate cancer.

Journal Article J Urol · March 2011 Featured Publication PURPOSE: Improvement in the cost-effectiveness of chemoprevention for prostate cancer could be realized through the identification of patients at higher risk. We estimated the cost-effectiveness of prostate cancer chemoprevention across risk groups defined ... Full text Link to item Cite

What do international pharmacoeconomic guidelines say about economic data transferability?

Journal Article Value Health · December 2010 Featured Publication OBJECTIVES: The objectives of this article were to assess the positions of the various national pharmacoeconomic guidelines on the transferability (or lack of transferability) of clinical and economic data and to review the methods suggested in the guideli ... Full text Link to item Cite

Costs of vasospasm in patients with aneurysmal subarachnoid hemorrhage.

Journal Article Neurosurgery · August 2010 Featured Publication OBJECTIVE: To assess the impact of vasospasm on costs, length of stay, and mortality among inpatients with aneurysmal subarachnoid hemorrhage. METHODS: We combined hospital accounting and physician billing data for a consecutive cohort of 198 patients who ... Full text Link to item Cite

Variation in the type and frequency of postoperative invasive Staphylococcus aureus infections according to type of surgical procedure.

Journal Article Infect Control Hosp Epidemiol · July 2010 OBJECTIVE: To determine the epidemiological characteristics of postoperative invasive Staphylococcus aureus infection following 4 types of major surgical procedures.design. Retrospective cohort study. SETTING: Eleven hospitals (9 community hospitals and 2 ... Full text Open Access Link to item Cite

Economic evaluation of the HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) randomized controlled trial: an exercise training study of patients with chronic heart failure.

Journal Article Circ Cardiovasc Qual Outcomes · July 2010 Featured Publication BACKGROUND: Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) assigned 2331 outpatients with medically stable heart failure to exercise training or usual care. We compared medical resource use and costs incurred by t ... Full text Link to item Cite

Can we close the income and wealth gap between specialists and primary care physicians?

Journal Article Health Aff (Millwood) · May 2010 Over their lifetimes, primary care physicians earn lower incomes--and accumulate considerably less wealth--than their specialist counterparts. This gap influences medical students, who are choosing careers in primary care in declining numbers. We estimated ... Full text Link to item Cite

Comparison of costs, length of stay, and mortality associated with Candida glabrata and Candida albicans bloodstream infections.

Journal Article Am J Infect Control · February 2010 Featured Publication We compared costs, length of stay, and mortality between adults with Candida albicans and Candida glabrata bloodstream infections. Early evidence of C glabrata, as defined by a positive culture within 2 days of admission, was associated with higher costs ( ... Full text Link to item Cite

Economic evaluation of home blood pressure monitoring with or without telephonic behavioral self-management in patients with hypertension.

Journal Article Am J Hypertens · February 2010 Featured Publication BACKGROUND: The Take Control of Your Blood Pressure trial evaluated the effect of a multicomponent telephonic behavioral lifestyle intervention, patient self-monitoring, and both interventions combined compared with usual care on reducing systolic blood pr ... Full text Link to item Cite

Costs and length of stay for patients with and without sickle cell disease after hysterectomy, appendectomy, or knee replacement.

Journal Article Am J Hematol · January 2010 Featured Publication Patients with sickle cell disease (SCD) who undergo surgical procedures experience greater risk for preoperative and postoperative complications than patients without SCD; however, the impact of SCD on inpatient resource use and costs had not been reported ... Full text Link to item Cite

Resource use and costs of treatment with anticoagulation and antiplatelet agents: results of the WATCH trial economic evaluation.

Journal Article J Card Fail · December 2009 Featured Publication BACKGROUND: The Warfarin and Antiplatelet Therapy in Chronic Heart Failure (WATCH) trial revealed no significant differences among 1587 symptomatic heart failure patients randomized to warfarin, clopidogrel, or aspirin in time to all-cause death, nonfatal ... Full text Link to item Cite

Two self-management interventions to improve hypertension control: a randomized trial.

Journal Article Ann Intern Med · November 17, 2009 BACKGROUND: Fewer than 40% of persons with hypertension in the United States have adequate blood pressure (BP) control. OBJECTIVE: To compare 2 self-management interventions for improving BP control among hypertensive patients. DESIGN: A 2 x 2 randomized t ... Full text Link to item Cite

Outcomes of inpatients with and without sickle cell disease after high-volume surgical procedures.

Journal Article Am J Hematol · November 2009 Featured Publication In this study, we examined differences in inpatient costs, length of stay, and in-hospital mortality between hospitalizations for patients with and without sickle cell disease (SCD) undergoing high-volume surgical procedures. We used Clinical Classificatio ... Full text Link to item Cite

Pattern and predictors of the initiation of biologic agents for the treatment of rheumatoid arthritis in the United States: an analysis using a large observational data bank.

Journal Article Clin Ther · August 2009 Featured Publication OBJECTIVE: The aim of this study was to identify factors associated with the initiation of biologic agents for the treatment of rheumatoid arthritis (RA) in a large US observational cohort. METHODS: Semiannual patient-reported data in the ARAMIS (Arthritis ... Full text Link to item Cite

Transferability of economic evaluations across jurisdictions: ISPOR Good Research Practices Task Force report.

Journal Article Value Health · June 2009 Featured Publication ABSTRACT A growing number of jurisdictions now request economic data in support of their decision-making procedures for the pricing and/or reimbursement of health technologies. Because more jurisdictions request economic data, the burden on study sponsors ... Full text Link to item Cite

Candida albicans and non-albicans bloodstream infections in adult and pediatric patients: comparison of mortality and costs.

Journal Article Pediatr Infect Dis J · May 2009 Featured Publication We compared length of stay, inpatient costs, and mortality associated with Candida albicans and non-albicans bloodstream infections in adults and children. Compared with adults, children with Candida bloodstream infections had longer lengths of stay (36.7 ... Full text Link to item Cite

Cost effectiveness of ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment.

Journal Article J Clin Oncol · May 1, 2009 Featured Publication PURPOSE: Using data from a recent randomized trial, we evaluated the cost effectiveness of ixabepilone plus capecitabine versus capecitabine alone in patients with predominantly metastatic breast cancer considered to be taxane-resistant and previously trea ... Full text Link to item Cite

Outcomes of Staphylococcus aureus infection in hemodialysis-dependent patients.

Journal Article Clin J Am Soc Nephrol · February 2009 Featured Publication BACKGROUND AND OBJECTIVES: Staphylococcus aureus is a leading cause of infection in patients with ESRD. Clinical and economic outcomes associated with S. aureus bacteremia and other S. aureus infections in patients with ESRD were examined. DESIGN, SETTING, ... Full text Link to item Cite

Cost-effectiveness of the oral adsorbent AST-120 versus placebo for chronic kidney disease.

Journal Article Nephrology (Carlton) · October 2008 AIM: This study was designed to evaluate the cost-effectiveness of AST-120, an oral adsorbent that attenuates the progression of chronic kidney disease. METHODS: We developed a Markov model with six health states, including four levels of serum creatinine, ... Full text Link to item Cite

Clinical outcomes and costs among patients with Staphylococcus aureus bacteremia and orthopedic device infections.

Journal Article Scandinavian journal of infectious diseases · July 2008 We evaluated costs and outcomes of patients with S. aureus bacteremia and orthopedic device infections (ODI). Patients with ODI had higher relapse of S. aureus infection, compared to bacteremic patients without ODI. Costs and outcomes were similar among OD ... Cite

A financial analysis of operative facial fracture management.

Journal Article Plast Reconstr Surg · April 2008 BACKGROUND: The financial impact of operative facial fracture management has not been systematically investigated. This study aims to provide a descriptive financial analysis of patients undergoing operative facial fracture management at a single academic ... Full text Link to item Cite

Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation.

Journal Article Crit Care Med · March 2008 OBJECTIVE: The economic implications of sedative choice in the management of patients receiving mechanical ventilation are unclear because of differences in costs and clinical outcomes associated with specific sedatives. Therefore, we aimed to determine th ... Full text Link to item Cite

Economic implications of potential changes to regulatory and reimbursement policies for medical devices.

Journal Article J Gen Intern Med · January 2008 Featured Publication OBJECTIVE: To evaluate the impact of regulatory scenarios on the financial viability of medical device companies. DESIGN: We developed a model to calculate the expected net present value of a hypothetical product throughout preclinical development, clinica ... Full text Link to item Cite

Updated estimates of survival and cost effectiveness for imatinib versus interferon-alpha plus low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukaemia.

Journal Article Pharmacoeconomics · 2008 Featured Publication BACKGROUND: For trials in which participants are followed beyond the main study period to assess long-term outcomes, economic evaluations conducted using short-term data should be systematically updated to reflect new information. METHODS: We used 60-month ... Full text Link to item Cite

Use of larger versus smaller drug-safety databases before regulatory approval: the trade-offs.

Journal Article Health Aff (Millwood) · 2008 Featured Publication Although efforts to revamp the drug-safety system have been directed at strengthening postmarketing surveillance, strategies for the preapproval stage may be useful. One strategy would be to require larger sample sizes in preapproval safety databases. To e ... Full text Link to item Cite

Clinical outcomes and costs among patients with Staphylococcus aureus bacteremia and orthopedic device infections.

Journal Article Scand J Infect Dis · 2008 We evaluated costs and outcomes of patients with S. aureus bacteremia and orthopedic device infections (ODI). Patients with ODI had higher relapse of S. aureus infection, compared to bacteremic patients without ODI. Costs and outcomes were similar among OD ... Full text Link to item Cite

Characteristics of nontraumatic subarachnoid hemorrhage in the United States in 2003.

Journal Article Neurosurgery · December 2007 OBJECTIVE: Substantial progress has been made in the diagnosis and treatment of subarachnoid hemorrhage (SAH). However, studies of SAH in the United States do not include information more recent than 2001, precluding analysis of shifts in treatment methods ... Full text Link to item Cite

Financial implications of a model heart failure disease management program for providers, hospital, healthcare systems, and payer perspectives.

Journal Article Am J Cardiol · January 15, 2007 Although heart failure disease management (HFDM) programs improve patient outcomes, the implementation of these programs has been limited because of financial barriers. We undertook the present study to understand the economic incentives and disincentives ... Full text Link to item Cite

Is there a price to pay for short-term savings in the clinical development of new pharmaceutical products?

Journal Article Drug Information Journal · January 1, 2007 Clinical development of new pharmaceutical compounds has historically been geared toward meeting the information demands of regulatory agencies while minimizing the cost and duration of the drug development process. One strategy for meeting these objective ... Full text Cite

Patterns of antibiotic use for patients with mild cystic fibrosis

Journal Article PEDIATRIC PULMONOLOGY · January 1, 2007 Link to item Cite

Updated Cost-Effectiveness Analysis of First-Line Imatinib Compared to Interferon-α in Patients with Newly Diagnosed Chronic Myeloid Leukemia in the Chronic Phase Using 60-Month Data from IRIS.

Conference Blood · November 16, 2006 AbstractBackground: Our previous cost-effectiveness analysis of first-line imatinib versus interferon- plus low-dose cytarabine in newly diagnosed patients with CML in the chronic phase was based on a median ... Full text Cite

Geographic variation in the treatment of acute myocardial infarction in the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial.

Journal Article Am Heart J · September 2006 Featured Publication BACKGROUND: The VALIANT trial compared the efficacy and safety of captopril, valsartan, and their combination in patients with left ventricular systolic dysfunction, heart failure, or both after acute myocardial infarction (MI). By examining this internati ... Full text Link to item Cite

Relationship between clinical outcomes and vascular access type among hemodialysis patients with Staphylococcus aureus bacteremia.

Journal Article Clin J Am Soc Nephrol · May 2006 The association between hemodialysis vascular access type, costs, and outcome of Staphylococcus aureus bacteremia (SAB) among patients with ESRD remains incompletely characterized. This study was undertaken to compare resource utilization, costs, and clini ... Full text Link to item Cite

Cost savings with implementation of PNA FISH testing for identification of Candida albicans in blood cultures.

Journal Article Diagn Microbiol Infect Dis · April 2006 Antifungal expenditures are substantial for many hospitals. Using caspofungin for the treatment of candidemia accounts for a sizable proportion of the costs. A cost minimization study that used a decision analytic model was done to compare in-hospital diag ... Full text Link to item Cite

The effect of valsartan, captopril, or both on atherosclerotic events after acute myocardial infarction: an analysis of the Valsartan in Acute Myocardial Infarction Trial (VALIANT).

Journal Article J Am Coll Cardiol · February 21, 2006 OBJECTIVES: We attempted to compare the effect of an angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) on atherosclerotic events. BACKGROUND: Angiotensin-converting enzyme inhibitors and ARBs interrupt the renin-angiotens ... Full text Link to item Cite

Analytic considerations in economic evaluations of multinational cardiovascular clinical trials.

Journal Article Value Health · 2006 Featured Publication OBJECTIVES: The growing number of economic evaluations that use data collected in multinational clinical trials raises numerous questions regarding their execution and interpretation. Although recommendations for conducting economic evaluations have been w ... Full text Link to item Cite

How changes in drug-safety regulations affect the way drug and biotech companies invest in innovation.

Journal Article Health Aff (Millwood) · 2006 Featured Publication Changes in the economics of product development resulting from heightened safety regulations could have a sizable negative impact on drug and biotechnology companies' decisions about investing in innovation. We developed a model to compare the potential ec ... Full text Link to item Cite

Economic evaluation of weekly epoetin alfa versus biweekly darbepoetin alfa for chemotherapy-induced anaemia: evidence from a 16-week randomised trial.

Journal Article Pharmacoeconomics · 2006 Featured Publication INTRODUCTION: A 16-week, open-label, multicentre, randomised trial of weekly epoetin alfa 40 000 units versus biweekly darbepoetin alfa 200microg among 358 patients with solid-tumour cancers and chemotherapy-induced anaemia demonstrated superior haematolog ... Full text Link to item Cite

Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes.

Journal Article Am J Med · December 2005 PURPOSE: Although Staphylococcus aureus is a leading cause of nosocomial infection, little is known about the impact of S. aureus bacteremia on patients with prosthetic devices. This investigation sought to define the clinical outcome, health care resource ... Full text Link to item Cite

Early hemoglobin response and alternative metrics of efficacy with erythropoietic agents for chemotherapy-related anemia.

Journal Article Curr Med Res Opin · October 2005 Featured Publication OBJECTIVE: To examine associations between early hemoglobin response and alternative measures of efficacy following treatment with an erythropoietic agent for chemotherapy-related anemia. RESEARCH DESIGN AND METHODS: Preliminary data from an ongoing random ... Full text Link to item Cite

Impact of disease severity and gastrointestinal side effects on the health state preferences of patients with osteoarthritis.

Journal Article Arthritis Rheum · August 2005 OBJECTIVE: To describe the health state preferences of patients with osteoarthritis (OA) according to the level of pain and disability and the extent of gastrointestinal side effects from nonsteroidal antiinflammatory drugs (NSAIDs). METHODS: Using combina ... Full text Link to item Cite

Resource use, costs, and quality of life among patients in the multinational Valsartan in Acute Myocardial Infarction Trial (VALIANT).

Journal Article Am Heart J · August 2005 Featured Publication BACKGROUND: In a multinational clinical trial, valsartan was statistically not inferior to captopril in reducing mortality and cardiovascular morbidity after myocardial infarction (MI) in patients with signs of heart failure and/or left ventricular dysfunc ... Full text Link to item Cite

Clinical outcomes and costs due to Staphylococcus aureus bacteremia among patients receiving long-term hemodialysis.

Journal Article Infect Control Hosp Epidemiol · June 2005 OBJECTIVE: To examine the clinical outcomes and costs associated with Staphylococcus aureus bacteremia among hemodialysis-dependent patients. DESIGN: Prospectively identified cohort study. SETTING: A tertiary-care university medical center in North Carolin ... Full text Link to item Cite

Conducting economic evaluations alongside multinational clinical trials: toward a research consensus.

Journal Article Am Heart J · March 2005 Featured Publication Demand for economic evaluations in multinational clinical trials is increasing, but there is little consensus about how such studies should be conducted and reported. At a workshop in Durham, North Carolina, we sought to identify areas of agreement about h ... Full text Link to item Cite

Economic evaluation of everolimus vs. azathioprine at one year after de novo heart transplantation.

Journal Article Clin Transplant · February 2005 BACKGROUND: Everolimus decreases acute rejection and cardiac allograft vasculopathy after heart transplantation. We compared within-trial costs and resource use over 1 yr of follow-up in de novo heart transplant patients randomized to everolimus 1.5 mg/d ( ... Full text Link to item Cite

Economic evaluation of zoledronic acid versus pamidronate for the prevention of skeletal-related events in metastatic breast cancer and multiple myeloma.

Journal Article Am J Clin Oncol · February 2005 Skeletal complications of cancer decrease health-related quality of life. Bisphosphonates can prevent skeletal-related events. We collected resource use data prospectively for 930 patients alongside a multinational trial of zoledronic acid versus pamidrona ... Full text Link to item Cite

Costs and outcomes among hemodialysis-dependent patients with methicillin-resistant or methicillin-susceptible Staphylococcus aureus bacteremia.

Journal Article Infect Control Hosp Epidemiol · February 2005 Featured Publication OBJECTIVE: Comorbid conditions have complicated previous analyses of the consequences of methicillin resistance for costs and outcomes of Staphylococcus aureus bacteremia. We compared costs and outcomes of methicillin resistance in patients with S. aureus ... Full text Link to item Cite

Good research practices for cost-effectiveness analysis alongside clinical trials: the ISPOR RCT-CEA Task Force report.

Journal Article Value Health · 2005 OBJECTIVES: A growing number of prospective clinical trials include economic end points. Recognizing the variation in methodology and reporting of these studies, the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) chartered the Ta ... Full text Link to item Cite

Pharmacy-based assessment of adherence to HAART predicts virologic and immunologic treatment response and clinical progression to AIDS and death.

Journal Article Int J STD AIDS · December 2004 Although adherence to HAART at a level above 95% has been associated with optimal viral suppression, the impact of different levels of adherence on long-term clinical outcomes has not been determined. We used an objective pharmacy-based measure to examine ... Full text Link to item Cite

Cost-effectiveness of imatinib versus interferon-alpha plus low-dose cytarabine for patients with newly diagnosed chronic-phase chronic myeloid leukemia.

Journal Article Cancer · December 1, 2004 Featured Publication BACKGROUND: Despite a lack of long-term data, imatinib has become standard therapy for patients with newly diagnosed chronic-phase chronic myeloid leukemia (CML) who are not candidates for allogeneic stem cell transplantation. In the current study, the aut ... Full text Link to item Cite

Long-term survival estimates for imatinib versus interferon-alpha plus low-dose cytarabine for patients with newly diagnosed chronic-phase chronic myeloid leukemia.

Journal Article Cancer · December 1, 2004 Featured Publication BACKGROUND: The authors estimated survival among patients with chronic myeloid leukemia for a cost-effectiveness analysis of imatinib versus interferon-alpha plus low-dose cytarabine (IFN+LDAC). METHODS: Two-year survival and cytogenetic response were dete ... Full text Link to item Cite

Parents' reported preference scores for childhood atopic dermatitis disease states.

Journal Article BMC Pediatr · October 18, 2004 BACKGROUND: We sought to elicit preference weights from parents for health states corresponding to children with various levels of severity of atopic dermatitis. We also evaluated the hypothesis that parents with children who had been diagnosed with atopic ... Full text Link to item Cite

Multinational economic evaluation of valsartan in patients with chronic heart failure: results from the Valsartan Heart Failure Trial (Val-HeFT).

Journal Article Am Heart J · July 2004 BACKGROUND: The Valsartan Heart Failure Trial (Val-HeFT) compared valsartan versus placebo in 5010 patients taking prescribed background therapy for New York Heart Association class II to IV heart failure. Valsartan reduced the risk of heart failure hospit ... Full text Link to item Cite

Cost-effectiveness of zoledronic acid for the prevention of skeletal complications in patients with prostate cancer.

Journal Article J Urol · April 2004 PURPOSE: We estimated the cost-effectiveness of zoledronic acid vs placebo for decreasing skeletal complications in men with prostate cancer. MATERIALS AND METHODS: We performed a cost-effectiveness analysis alongside a multinational clinical trial of zole ... Full text Link to item Cite

The economic burden of allergic rhinitis: a critical evaluation of the literature.

Journal Article Pharmacoeconomics · 2004 Although a large number of economic analyses of allergic rhinitis have been published, there are relatively few empirically based studies, particularly outside the US. The majority of these analyses can be classified as burden-of-illness studies. Most esti ... Full text Link to item Cite

A multinational review of recent trends and reports in dementia caregiver burden.

Journal Article Alzheimer Dis Assoc Disord · 2004 This systematic review of the literature focuses on the influence of ethnic, cultural, and geographic factors on the caregivers of patients with dementia. In particular, we explore the impact of cultural expectations on five important questions: 1) Do the ... Full text Link to item Cite

Economic analysis of conventional-dose chemotherapy compared with high-dose chemotherapy plus autologous hematopoietic stem-cell transplantation for metastatic breast cancer.

Journal Article Bone Marrow Transplant · February 2003 We performed an economic analysis of data from 180 women in a clinical trial of conventional-dose chemotherapy vs high-dose chemotherapy plus stem-cell transplantation for metastatic breast cancer responding to first-line chemotherapy. Data on resource use ... Full text Link to item Cite

Direct costs of allergic rhinitis in the United States: estimates from the 1996 Medical Expenditure Panel Survey.

Journal Article J Allergy Clin Immunol · February 2003 BACKGROUND: Previous estimates of the cost of allergic rhinitis predate the substantial increase in the use of second-generation antihistamines and intranasal corticosteroids. OBJECTIVE: We sought to update estimates of the direct costs of allergic rhiniti ... Full text Link to item Cite

A Bayesian approach to aid in formulary decision making: incorporating institution-specific cost-effectiveness data with clinical trial results.

Journal Article Med Decis Making · 2003 Featured Publication Pharmacy and therapeutics committees commonly cite a lack of generalizability as a reason for not incorporating cost-effectiveness information into decision making. To address this concern, many committees undertake site-specific economic evaluations, whic ... Full text Link to item Cite

The cost of inefficiency in US hospitals, 1985-1997.

Journal Article J Health Care Finance · 2003 We conducted a descriptive analysis of data from the Hospital Cost Report Information System from 1985 through 1997 on nonfederal, short-stay hospitals in the United States with 12-month reporting periods and valid data for the primary outcomes. The main o ... Link to item Cite

Comparison of hospital costing methods in an economic evaluation of a multinational clinical trial.

Journal Article Int J Technol Assess Health Care · 2003 Featured Publication OBJECTIVES: To develop and evaluate strategies for estimating hospitalization costs in multinational clinical trials. METHODS: Hospital cost estimates for eleven diagnoses were collected from twelve countries participating in a trial of therapies for conge ... Full text Link to item Cite

Management of allergic rhinitis in the working-age population.

Journal Article Evid Rep Technol Assess (Summ) · January 2003 Link to item Cite

Treatment patterns and costs associated with sessile colorectal polyps.

Journal Article Am J Gastroenterol · November 2002 OBJECTIVES: Because of the paucity of existing literature on treatment and costs associated with sessile lesions, the objectives of this study were to perform a retrospective analysis on patients with sessile polyps to identify patient and polyp characteri ... Full text Link to item Cite

Economic issues and antibiotic resistance in the community.

Journal Article Ann Pharmacother · January 2002 BACKGROUND: Inappropriate antibiotic use is generally considered to be the primary cause of antibiotic resistance in the community. Multiple economic factors, at the level of physicians, patients, healthcare organizations, and pharmaceutical companies, fos ... Full text Link to item Cite

Treatment with tissue plasminogen activator and inpatient mortality rates for patients with ischemic stroke treated in community hospitals.

Journal Article Stroke · August 2001 BACKGROUND AND PURPOSE: Most analyses of intravenous tissue plasminogen activator (IV tPA) use for acute stroke in routine practice have been limited by sample size and generally restricted to patients treated in large academic medical facilities. In the p ... Full text Link to item Cite

Inpatient costs, length of stay, and mortality for cerebrovascular events in community hospitals.

Journal Article Neurology · July 24, 2001 BACKGROUND: Accurate estimates of inpatient cost, length of stay (LOS), and mortality are necessary for the development of economic models to estimate the cost-effectiveness of stroke-related treatments. Estimates based on data from academic institutions m ... Full text Link to item Cite

Cost effectiveness of abciximab during routine medical practice.

Journal Article Pharmacoeconomics · September 2000 OBJECTIVE: To estimate the cost per ischaemic event (death, nonfatal myocardial infarction, subsequent revascularisation procedure) avoided at 6 months in high risk patients undergoing coronary revascularisation treated with abciximab during routine medica ... Full text Link to item Cite