Scholars@Duke
Eun-Sil Shelley Hwang

Eun-Sil Shelley Hwang

Mary and Deryl Hart Distinguished Professor of Surgery, in the School of Medicine
Surgical Oncology
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Selected Publications

Trajectory of Subsequent Breast Cancer Diagnoses in a Diverse Patient Cohort with Breast Atypia.

Journal Article Ann Surg Oncol · July 21, 2024 BACKGROUND: Proliferative breast atypical lesions, including atypical ductal hyperplasia (ADH) and lobular intraepithelial neoplasms (LIN), represent benign entities that confer an elevated risk of ductal carcinoma in situ (DCIS) and invasive breast cancer ... Full text Link to item Cite

Microcalcification crystallography as a potential marker of DCIS recurrence.

Journal Article Sci Rep · June 8, 2023 Ductal carcinoma in-situ (DCIS) accounts for 20-25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. T ... Full text Link to item Cite

Modifiable patient-reported factors associated with cancer-screening knowledge and participation in a community-based health assessment.

Journal Article Am J Surg · April 2023 BACKGROUND: We sought to identify modifiable factors associated with cancer screening in a community-based health assessment. METHODS: 24 organizations at 47 community events in central North Carolina distributed a 91-item survey from April-December 2017. ... Full text Link to item Cite

Surveillance Imaging after Primary Diagnosis of Ductal Carcinoma in Situ.

Journal Article Radiology · April 2023 Background Guidelines recommend annual surveillance imaging after diagnosis of ductal carcinoma in situ (DCIS). Guideline adherence has not been characterized in a contemporary cohort. Purpose To identify uptake and determinants of surveillance imaging in ... Full text Link to item Cite

Survival Benefit of Chemotherapy According to 21-Gene Recurrence Score in Young Women with Breast Cancer.

Journal Article Ann Surg Oncol · April 2023 BACKGROUND: Initial trials evaluating Oncotype DX, reported as a recurrence score (RS) from 0 to 100, were not powered to evaluate overall survival, and premenopausal women were underrepresented. The purpose of this study was to explore the benefit of chem ... Full text Link to item Cite

Modifiable Barriers and Facilitators for Breast Cancer Care: A Thematic Analysis of Patient and Provider Perspectives.

Journal Article J Surg Res · April 2023 INTRODUCTION: We sought to examine patient and provider perspectives regarding modifiable contributors to breast cancer treatment and to assess perceptual alignment between these two groups. MATERIALS: Participants were women≥18 y with stage 0-IV breast ca ... Full text Link to item Cite

Racial-ethnic variations in phyllodes tumors among a multicenter United States cohort.

Journal Article J Surg Oncol · March 2023 BACKGROUND AND OBJECTIVES: Previous studies have identified racial-ethnic differences in the diagnostic patterns and recurrence outcomes of women with phyllodes tumors (PT). However, these studies are generally limited in size and generalizability. We ther ... Full text Link to item Cite

De-escalation in DCIS Care

Journal Article Current Breast Cancer Reports · March 1, 2023 Purpose of Review: Standard DCIS management consists of surgery with consideration of adjuvant radiation and endocrine therapy. However, widespread recognition of the overdiagnosis and overtreatment burden in DCIS has led to a reevaluation of this standard ... Full text Cite

The role of tumor phenotype in the surgical treatment of early-stage breast cancer.

Conference Am J Surg · January 2023 BACKGROUND: We investigated whether tumor phenotype influences surgical decision-making, and how that may impact overall survival (OS) for early-stage breast cancer. METHODS: Women aged 18-69 with cT0-2/cN0/cM0 breast cancer in the National Cancer Database ... Full text Link to item Cite

Implications of missing data on reported breast cancer mortality.

Journal Article Breast Cancer Res Treat · January 2023 BACKGROUND: National cancer registries are valuable tools to analyze patterns of care and clinical outcomes; yet, missing data may impact the accuracy and generalizability of these data. We sought to evaluate the association between missing data and overal ... Full text Open Access Link to item Cite

Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts.

Journal Article Cancer Cell · December 12, 2022 Ductal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We perform multiscale, integrated molecular profiling of DCIS with clinical outcomes by analyzing 774 DCIS samples from ... Full text Link to item Cite

Learning to distinguish progressive and non-progressive ductal carcinoma in situ.

Journal Article Nat Rev Cancer · December 2022 Ductal carcinoma in situ (DCIS) is a non-invasive breast neoplasia that accounts for 25% of all screen-detected breast cancers diagnosed annually. Neoplastic cells in DCIS are confined to the ductal system of the breast, although they can escape and progre ... Full text Link to item Cite

Identifying Good Candidates for Active Surveillance of Ductal Carcinoma In Situ: Insights from a Large Neoadjuvant Endocrine Therapy Cohort.

Journal Article Cancer Res Commun · December 2022 UNLABELLED: Ductal carcinoma in situ (DCIS) is a biologically heterogenous entity with uncertain risk for invasive ductal carcinoma (IDC) development. Standard treatment is surgical resection often followed by radiation. New approaches are needed to reduce ... Full text Link to item Cite

The Influence of Body Mass Index on the Histopathology and Outcomes of Patients Diagnosed with Atypical Breast Lesions.

Conference Ann Surg Oncol · October 2022 BACKGROUND: Multiple studies have demonstrated a link between obesity and breast cancer; however, the potential association between obesity and atypical high-risk breast lesions has not been well characterized. We sought to evaluate the characteristics and ... Full text Link to item Cite

Spatial interplay of tissue hypoxia and T-cell regulation in ductal carcinoma in situ.

Journal Article NPJ Breast Cancer · September 15, 2022 Hypoxia promotes aggressive tumor phenotypes and mediates the recruitment of suppressive T cells in invasive breast carcinomas. We investigated the role of hypoxia in relation to T-cell regulation in ductal carcinoma in situ (DCIS). We designed a deep lear ... Full text Link to item Cite

Trajectory of Subsequent Breast Cancer Diagnoses in a Diverse Patient Cohort with Breast Atypia.

Journal Article Ann Surg Oncol · July 21, 2024 BACKGROUND: Proliferative breast atypical lesions, including atypical ductal hyperplasia (ADH) and lobular intraepithelial neoplasms (LIN), represent benign entities that confer an elevated risk of ductal carcinoma in situ (DCIS) and invasive breast cancer ... Full text Link to item Cite

Microcalcification crystallography as a potential marker of DCIS recurrence.

Journal Article Sci Rep · June 8, 2023 Ductal carcinoma in-situ (DCIS) accounts for 20-25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. T ... Full text Link to item Cite

Modifiable patient-reported factors associated with cancer-screening knowledge and participation in a community-based health assessment.

Journal Article Am J Surg · April 2023 BACKGROUND: We sought to identify modifiable factors associated with cancer screening in a community-based health assessment. METHODS: 24 organizations at 47 community events in central North Carolina distributed a 91-item survey from April-December 2017. ... Full text Link to item Cite

Surveillance Imaging after Primary Diagnosis of Ductal Carcinoma in Situ.

Journal Article Radiology · April 2023 Background Guidelines recommend annual surveillance imaging after diagnosis of ductal carcinoma in situ (DCIS). Guideline adherence has not been characterized in a contemporary cohort. Purpose To identify uptake and determinants of surveillance imaging in ... Full text Link to item Cite

Survival Benefit of Chemotherapy According to 21-Gene Recurrence Score in Young Women with Breast Cancer.

Journal Article Ann Surg Oncol · April 2023 BACKGROUND: Initial trials evaluating Oncotype DX, reported as a recurrence score (RS) from 0 to 100, were not powered to evaluate overall survival, and premenopausal women were underrepresented. The purpose of this study was to explore the benefit of chem ... Full text Link to item Cite

Modifiable Barriers and Facilitators for Breast Cancer Care: A Thematic Analysis of Patient and Provider Perspectives.

Journal Article J Surg Res · April 2023 INTRODUCTION: We sought to examine patient and provider perspectives regarding modifiable contributors to breast cancer treatment and to assess perceptual alignment between these two groups. MATERIALS: Participants were women≥18 y with stage 0-IV breast ca ... Full text Link to item Cite

Racial-ethnic variations in phyllodes tumors among a multicenter United States cohort.

Journal Article J Surg Oncol · March 2023 BACKGROUND AND OBJECTIVES: Previous studies have identified racial-ethnic differences in the diagnostic patterns and recurrence outcomes of women with phyllodes tumors (PT). However, these studies are generally limited in size and generalizability. We ther ... Full text Link to item Cite

De-escalation in DCIS Care

Journal Article Current Breast Cancer Reports · March 1, 2023 Purpose of Review: Standard DCIS management consists of surgery with consideration of adjuvant radiation and endocrine therapy. However, widespread recognition of the overdiagnosis and overtreatment burden in DCIS has led to a reevaluation of this standard ... Full text Cite

The role of tumor phenotype in the surgical treatment of early-stage breast cancer.

Conference Am J Surg · January 2023 BACKGROUND: We investigated whether tumor phenotype influences surgical decision-making, and how that may impact overall survival (OS) for early-stage breast cancer. METHODS: Women aged 18-69 with cT0-2/cN0/cM0 breast cancer in the National Cancer Database ... Full text Link to item Cite

Implications of missing data on reported breast cancer mortality.

Journal Article Breast Cancer Res Treat · January 2023 BACKGROUND: National cancer registries are valuable tools to analyze patterns of care and clinical outcomes; yet, missing data may impact the accuracy and generalizability of these data. We sought to evaluate the association between missing data and overal ... Full text Open Access Link to item Cite

Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts.

Journal Article Cancer Cell · December 12, 2022 Ductal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We perform multiscale, integrated molecular profiling of DCIS with clinical outcomes by analyzing 774 DCIS samples from ... Full text Link to item Cite

Learning to distinguish progressive and non-progressive ductal carcinoma in situ.

Journal Article Nat Rev Cancer · December 2022 Ductal carcinoma in situ (DCIS) is a non-invasive breast neoplasia that accounts for 25% of all screen-detected breast cancers diagnosed annually. Neoplastic cells in DCIS are confined to the ductal system of the breast, although they can escape and progre ... Full text Link to item Cite

Identifying Good Candidates for Active Surveillance of Ductal Carcinoma In Situ: Insights from a Large Neoadjuvant Endocrine Therapy Cohort.

Journal Article Cancer Res Commun · December 2022 UNLABELLED: Ductal carcinoma in situ (DCIS) is a biologically heterogenous entity with uncertain risk for invasive ductal carcinoma (IDC) development. Standard treatment is surgical resection often followed by radiation. New approaches are needed to reduce ... Full text Link to item Cite

The Influence of Body Mass Index on the Histopathology and Outcomes of Patients Diagnosed with Atypical Breast Lesions.

Conference Ann Surg Oncol · October 2022 BACKGROUND: Multiple studies have demonstrated a link between obesity and breast cancer; however, the potential association between obesity and atypical high-risk breast lesions has not been well characterized. We sought to evaluate the characteristics and ... Full text Link to item Cite

Spatial interplay of tissue hypoxia and T-cell regulation in ductal carcinoma in situ.

Journal Article NPJ Breast Cancer · September 15, 2022 Hypoxia promotes aggressive tumor phenotypes and mediates the recruitment of suppressive T cells in invasive breast carcinomas. We investigated the role of hypoxia in relation to T-cell regulation in ductal carcinoma in situ (DCIS). We designed a deep lear ... Full text Link to item Cite

Prediction Models and Decision Aids for Women with Ductal Carcinoma In Situ: A Systematic Literature Review.

Journal Article Cancers (Basel) · July 2, 2022 Even though Ductal Carcinoma in Situ (DCIS) can potentially be an invasive breast cancer (IBC) precursor, most DCIS lesions never will progress to IBC if left untreated. Because we cannot predict yet which DCIS lesions will and which will not progress, alm ... Full text Link to item Cite

Clinical Impact of Intraoperative Margin Assessment in Breast-Conserving Surgery With a Novel Pegulicianine Fluorescence-Guided System: A Nonrandomized Controlled Trial.

Journal Article JAMA Surg · July 1, 2022 IMPORTANCE: Positive margins following breast-conserving surgery (BCS) are often identified on standard pathology evaluation. Intraoperative assessment of the lumpectomy cavity has the potential to reduce residual disease or reexcision rate following stand ... Full text Link to item Cite

Adaptive stress response genes associated with breast cancer subtypes and survival outcomes reveal race-related differences.

Journal Article NPJ Breast Cancer · June 13, 2022 Aggressive breast cancer variants, like triple negative and inflammatory breast cancer, contribute to disparities in survival and clinical outcomes among African American (AA) patients compared to White (W) patients. We previously identified the dominant r ... Full text Open Access Link to item Cite

A Multidimensional Bioinformatic Platform for the Study of Human Response to Surgery.

Journal Article Ann Surg · June 1, 2022 OBJECTIVE: To design and establish a prospective biospecimen repository that integrates multi-omics assays with clinical data to study mechanisms of controlled injury and healing. BACKGROUND: Elective surgery is an opportunity to understand both the system ... Full text Link to item Cite

Immunosuppressive glycoproteins associate with breast tumor fibrosis and aggression.

Journal Article Matrix Biol Plus · June 2022 Tumors feature elevated sialoglycoprotein content. Sialoglycoproteins promote tumor progression and are linked to immune suppression via the sialic acid-Siglec axis. Understanding factors that increase sialoglycoprotein biosynthesis in tumors could identif ... Full text Link to item Cite

Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer.

Journal Article Nat Genet · June 2022 Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5-10%) of DCIS patients develop subsequent invasive disease. A fundamental biologic question is whether the invasive disease aris ... Full text Link to item Cite

Disparities at the Intersection of Race and Ethnicity: Examining Trends and Outcomes in Hispanic Women With Breast Cancer.

Journal Article JCO Oncol Pract · May 2022 PURPOSE: We sought to examine tumor subtype, stage at diagnosis, time to surgery (TTS), and overall survival (OS) among Hispanic patients of different races and among Hispanic and non-Hispanic (NH) women of the same race. METHODS: Women 18 years of age or ... Full text Link to item Cite

Malignant phyllodes tumor and primary breast sarcoma; distinct rare tumors of the breast.

Conference J Surg Oncol · May 2022 BACKGROUND: Malignant phyllodes (MP) and primary breast sarcomas (PBS) are rare neoplasms with overlapping histopathologic features. We compared overall survival (OS) and estimated the association of surgery and therapies with OS. METHODS: We utilized the ... Full text Link to item Cite

Anomaly Detection of Calcifications in Mammography Based on 11,000 Negative Cases.

Journal Article IEEE Trans Biomed Eng · May 2022 In mammography, calcifications are one of the most common signs of breast cancer. Detection of such lesions is an active area of research for computer-aided diagnosis and machine learning algorithms. Due to limited numbers of positive cases, many supervise ... Full text Link to item Cite

Racial and Ethnic Disparities in Surgical Outcomes after Postmastectomy Breast Reconstruction.

Journal Article J Am Coll Surg · May 1, 2022 BACKGROUND: Women of color with breast cancer are less likely to undergo post-mastectomy reconstruction compared with White women, but it is unclear whether their perioperative outcomes are worse. The goal of this study was to investigate differences in pr ... Full text Link to item Cite

"Is it cancer or not?" A qualitative exploration of survivor concerns surrounding the diagnosis and treatment of ductal carcinoma in situ.

Journal Article Cancer · April 15, 2022 BACKGROUND: Of the nearly 50,000 women in the United States who undergo treatment for ductal carcinoma in situ (DCIS) annually, many may not benefit from treatment. To better understand the impact of a DCIS diagnosis, patients self-identified as having had ... Full text Link to item Cite

A multi-modal exploration of heterogeneous physico-chemical properties of DCIS breast microcalcifications.

Journal Article Analyst · April 11, 2022 Ductal carcinoma in situ (DCIS) is frequently associated with breast calcification. This study combines multiple analytical techniques to investigate the heterogeneity of these calcifications at the micrometre scale. X-ray diffraction, scanning electron mi ... Full text Link to item Cite

Development of a new adapted QuinteT Recruitment Intervention (QRI-Two) for rapid application to RCTs underway with enrolment shortfalls-to identify previously hidden barriers and improve recruitment.

Journal Article Trials · April 4, 2022 BACKGROUND: Many randomised controlled trials (RCTs) struggle to recruit, despite valiant efforts. The QRI (QuinteT Recruitment Intervention) uses innovative research methods to optimise recruitment by revealing previously hidden barriers related to the pe ... Full text Link to item Cite

A Novel Staging System for De Novo Metastatic Breast Cancer Refines Prognostic Estimates.

Journal Article Ann Surg · April 1, 2022 OBJECTIVE: We aim to identify prognostic groups within a de novo metastatic cohort, incorporating both anatomic and biologic factors. BACKGROUND: Staging for breast cancer now includes anatomic and biologic factors, although the guidelines for stage IV dis ... Full text Link to item Cite

A web-based personalized decision support tool for patients diagnosed with ductal carcinoma in situ: development, content evaluation, and usability testing.

Conference Breast Cancer Res Treat · April 2022 PURPOSE: Patients diagnosed with ductal carcinoma in situ (DCIS) face trade-offs when deciding among different treatments, including surgery, radiation, and endocrine therapy. A less chosen option is active monitoring. While evidence from clinical trials i ... Full text Link to item Cite

Prediction of Upstaging in Ductal Carcinoma in Situ Based on Mammographic Radiomic Features.

Journal Article Radiology · April 2022 Background Improving diagnosis of ductal carcinoma in situ (DCIS) before surgery is important in choosing optimal patient management strategies. However, patients may harbor occult invasive disease not detected until definitive surgery. Purpose To assess t ... Full text Link to item Cite

Estimation of Breast Cancer Overdiagnosis in a U.S. Breast Screening Cohort.

Journal Article Ann Intern Med · April 2022 BACKGROUND: Mammography screening can lead to overdiagnosis-that is, screen-detected breast cancer that would not have caused symptoms or signs in the remaining lifetime. There is no consensus about the frequency of breast cancer overdiagnosis. OBJECTIVE: ... Full text Link to item Cite

Disease characteristics and mortality among Asian women with breast cancer.

Conference Cancer · March 1, 2022 BACKGROUND: Asian women with breast cancer are often studied in aggregate, belying significant intragroup diversity. The authors sought to examine differences in breast cancer characteristics and outcomes among Asian women. METHODS: Asian, non-Hispanic Bla ... Full text Link to item Cite

MITI minimum information guidelines for highly multiplexed tissue images.

Journal Article Nat Methods · March 2022 The imminent release of tissue atlases combining multi-channel microscopy with single cell sequencing and other omics data from normal and diseased specimens creates an urgent need for data and metadata standards that guide data deposition, curation and re ... Full text Link to item Cite

Mouse-INtraDuctal (MIND): an in vivo model for studying the underlying mechanisms of DCIS malignancy.

Journal Article J Pathol · February 2022 Due to widespread adoption of screening mammography, there has been a significant increase in new diagnoses of ductal carcinoma in situ (DCIS). However, DCIS prognosis remains unclear. To address this gap, we developed an in vivo model, Mouse-INtraDuctal ( ... Full text Link to item Cite

Utilization of neoadjuvant chemotherapy in high-risk, node-negative early breast cancer.

Journal Article Cancer Med · February 2022 BACKGROUND: Controversy exists regarding the optimal sequence of chemotherapy among women with operable node-negative breast cancers with high-risk tumor biology. We evaluated national patterns of neoadjuvant chemotherapy (NACT) use among women with early- ... Full text Link to item Cite

Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma.

Journal Article Cell · January 20, 2022 Ductal carcinoma in situ (DCIS) is a pre-invasive lesion that is thought to be a precursor to invasive breast cancer (IBC). To understand the changes in the tumor microenvironment (TME) accompanying transition to IBC, we used multiplexed ion beam imaging b ... Full text Link to item Cite

Metastatic breast cancer: Who benefits from surgery?

Journal Article Am J Surg · January 2022 BACKGROUND: We sought to identify characteristics of metastatic breast cancer (MBC) patients who may benefit most from primary tumor resection. METHODS: Recursive partitioning analysis (RPA) was used to categorize non-surgical patients with de novo MBC in ... Full text Link to item Cite

Automated Dcis Identification From Multiplex Immunohistochemistry Using Generative Adversarial Networks

Conference Proceedings - International Symposium on Biomedical Imaging · January 1, 2022 Ductal Carcinoma In Situ (DCIS) is a non-obligatory precursor of Invasive Breast Cancer. It is the most common mammographically detected breast cancer. Predicting DCIS progression to invasive ductal carcinoma is a major clinical challenge due to the lack o ... Full text Cite

DCIS AI-TIL: Ductal Carcinoma In Situ Tumour Infiltrating Lymphocyte Scoring Using Artificial Intelligence

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2022 Tumour infiltrating lymphocytes (TIL) influence the prognosis of Ductal carcinoma in situ (DCIS). Currently, manual assessment of TIL by expert pathologists is considered a gold standard. However, there are issues with a shortage of expert pathologists and ... Full text Cite

Genomic predictor can discriminate between high- and low-risk DCIS

Conference CANCER PREVENTION RESEARCH · 2022 Cite

Reprogramming of fibrotic macrophages to control DCIS progression

Conference CANCER PREVENTION RESEARCH · 2022 Cite

Reprogramming of fibrotic macrophages to control DCIS progression

Conference CANCER PREVENTION RESEARCH · 2022 Cite

Genomic predictor can discriminate between high- and low-risk DCIS

Conference CANCER PREVENTION RESEARCH · 2022 Cite

Unmasking the immune microecology of ductal carcinoma in situ with deep learning

Conference npj Breast Cancer · December 1, 2021 Despite increasing evidence supporting the clinical relevance of tumour infiltrating lymphocytes (TILs) in invasive breast cancer, TIL spatial variability within ductal carcinoma in situ (DCIS) samples and its association with progression are not well unde ... Full text Cite

Breast cancer-derived DAMPs enhance cell invasion and metastasis, while nucleic acid scavengers mitigate these effects.

Journal Article Molecular therapy. Nucleic acids · December 2021 Breast cancer (BC) is the most common malignancy in women. Particular subtypes with aggressive behavior are major contributors to poor outcomes. Triple-negative breast cancer (TNBC) is difficult to treat, pro-inflammatory, and highly metastatic. We demonst ... Full text Cite

Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score.

Journal Article Br J Surg · November 11, 2021 To support the global restart of elective surgery, data from an international prospective cohort study of 8492 patients (69 countries) was analysed using artificial intelligence (machine learning techniques) to develop a predictive score for mortality in s ... Full text Open Access Link to item Cite

Impact of Bacillus Calmette-Guérin (BCG) vaccination on postoperative mortality in patients with perioperative SARS-CoV-2 infection.

Journal Article BJS Open · November 9, 2021 There is little evidence around the potentially protective role of previous Bacillus Calmette-Guerin (BCG) vaccination on postoperative mortality in patients with perioperative SARS-CoV-2 vaccination. Prior BCG vaccination did not protect SARS-CoV-2 infect ... Full text Open Access Link to item Cite

A new method to accurately identify single nucleotide variants using small FFPE breast samples.

Journal Article Brief Bioinform · November 5, 2021 Most tissue collections of neoplasms are composed of formalin-fixed and paraffin-embedded (FFPE) excised tumor samples used for routine diagnostics. DNA sequencing is becoming increasingly important in cancer research and clinical management; however it is ... Full text Link to item Cite

Patient Preferences for Outcomes Following DCIS Management Strategies: A Discrete Choice Experiment.

Journal Article JCO Oncol Pract · November 2021 PURPOSE: Ductal carcinoma in situ (DCIS), a nonobligate precursor of breast cancer, is often aggressively managed with multimodal therapy. However, there is limited research on patients' preferences for trade-offs among treatment-related outcomes such as b ... Full text Link to item Cite

Survival Outcomes Among Patients with Metastatic Breast Cancer: Review of 47,000 Patients.

Conference Ann Surg Oncol · November 2021 BACKGROUND: Although metastatic breast cancer (MBC) remains incurable, advances in therapies have improved survival. Using a contemporary dataset of de novo MBC patients, we explore how overall (OS) and cancer-specific survival (CSS) changed over time. MET ... Full text Link to item Cite

Long-term risk of subsequent ipsilateral lesions after surgery with or without radiotherapy for ductal carcinoma in situ of the breast.

Journal Article Br J Cancer · November 2021 BACKGROUND: Radiotherapy (RT) following breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) reduces ipsilateral breast event rates in clinical trials. This study assessed the impact of DCIS treatment on a 20-year risk of ipsilateral DCIS (i ... Full text Link to item Cite

Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.

Journal Article Lancet Oncol · November 2021 BACKGROUND: Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during ... Full text Link to item Cite

Factors Associated with Nodal Pathologic Complete Response Among Breast Cancer Patients Treated with Neoadjuvant Chemotherapy: Results of CALGB 40601 (HER2+) and 40603 (Triple-Negative) (Alliance).

Conference Ann Surg Oncol · October 2021 BACKGROUND: De-escalation of axillary surgery after neoadjuvant chemotherapy (NAC) requires careful patient selection. We seek to determine predictors of nodal pathologic complete response (ypN0) among patients treated on CALGB 40601 or 40603, which tested ... Full text Link to item Cite

Mortality in Older Patients with Breast Cancer Undergoing Breast Surgery: How Low is "Low Risk"?

Conference Ann Surg Oncol · October 2021 BACKGROUND: Breast surgery carries a low risk of postoperative mortality. For older patients with multiple comorbidities, even low-risk procedures can confer some increased perioperative risk. We sought to identify factors associated with postoperative mor ... Full text Link to item Cite

Contralateral Axillary Nodal Metastases: Stage IV Disease or a Manifestation of Progressive Locally Advanced Breast Cancer?

Conference Ann Surg Oncol · October 2021 BACKGROUND: Contralateral axillary nodal metastases (CAM) is classified as stage IV disease, although many centers treat CAM with curative intent. We hypothesized that patients with CAM, treated with multimodality therapy, would have improved overall survi ... Full text Link to item Cite

Best Practices for Spatial Profiling for Breast Cancer Research with the GeoMx® Digital Spatial Profiler.

Journal Article Cancers (Basel) · September 4, 2021 Breast cancer is a heterogenous disease with variability in tumor cells and in the surrounding tumor microenvironment (TME). Understanding the molecular diversity in breast cancer is critical for improving prediction of therapeutic response and prognostica ... Full text Link to item Cite

Mobile Health Application for Patients Undergoing Breast Cancer Surgery: Feasibility Study.

Journal Article JCO Oncol Pract · September 2021 PURPOSE: Contemporary breast cancer surgery often requires hospital stays of 1 day or less, presenting challenges to delivery of high-quality care. Without sufficient time for proper education and guidance, patients may delay seeking care, experience anxie ... Full text Link to item Cite

Updated Standardized Definitions for Efficacy End Points (STEEP) in Adjuvant Breast Cancer Clinical Trials: STEEP Version 2.0.

Journal Article J Clin Oncol · August 20, 2021 PURPOSE: The Standardized Definitions for Efficacy End Points (STEEP) criteria, established in 2007, provide standardized definitions of adjuvant breast cancer clinical trial end points. Given the evolution of breast cancer clinical trials and improvements ... Full text Link to item Cite

Characterizing participants in the North Carolina Breast and Cervical Cancer Control Program: A retrospective review of 90,000 women.

Conference Cancer · July 15, 2021 BACKGROUND: The North Carolina Breast and Cervical Cancer Control Program (NC BCCCP) provides breast cancer screening services to underserved women to mitigate disparities in access to care. The authors sought to characterize this understudied population. ... Full text Link to item Cite

Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates.

Journal Article NPJ Breast Cancer · July 2, 2021 Management of breast cancer in limited-resource settings is hindered by a lack of low-cost, logistically sustainable approaches toward molecular and cellular diagnostic pathology services that are needed to guide therapy. To address these limitations, we h ... Full text Link to item Cite

Association of Smartphone Ownership and Internet Use With Markers of Health Literacy and Access: Cross-sectional Survey Study of Perspectives From Project PLACE (Population Level Approaches to Cancer Elimination).

Journal Article J Med Internet Res · June 9, 2021 BACKGROUND: Telehealth is an increasingly important component of health care delivery in response to the COVID-19 pandemic. However, well-documented disparities persist in the use of digital technologies. OBJECTIVE: This study aims to describe smartphone a ... Full text Link to item Cite

Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer.

Journal Article J Exp Med · May 3, 2021 Triple-negative breast cancers (TNBCs) are associated with poor survival mediated by treatment resistance. TNBCs are fibrotic, yet little is known regarding how the extracellular matrix (ECM) evolves following therapy and whether it impacts treatment respo ... Full text Link to item Cite

Neoadjuvant Chemotherapy, Endocrine Therapy, and Targeted Therapy for Breast Cancer: ASCO Guideline.

Journal Article J Clin Oncol · May 1, 2021 PURPOSE: To develop guideline recommendations concerning optimal neoadjuvant therapy for breast cancer. METHODS: ASCO convened an Expert Panel to conduct a systematic review of the literature on neoadjuvant therapy for breast cancer and provide recommended ... Full text Link to item Cite

Outcomes and Costs for Women After Breast Cancer: Preparing for Improved Survivorship of Medicare Beneficiaries.

Journal Article JCO Oncol Pract · April 2021 PURPOSE: Increasing health care costs, longer life expectancy, improved breast cancer (BC) survival, and higher levels of complex comorbidities have important implications for future Medicare expenditures. METHODS: Data from the SEER program linked to Medi ... Full text Link to item Cite

Mixed-Methods Study to Predict Upstaging of DCIS to Invasive Disease on Mammography.

Journal Article AJR Am J Roentgenol · April 2021 BACKGROUND. The incidence of ductal carcinoma in situ (DCIS) has steadily increased, as have concerns regarding overtreatment. Active surveillance is a novel treatment strategy that avoids surgical excision, but identifying patients with occult invasive di ... Full text Link to item Cite

Treatment Patterns and Outcomes of Women with Breast Cancer and Supraclavicular Nodal Metastases.

Journal Article Ann Surg Oncol · April 2021 BACKGROUND: In 2002, breast cancer patients with supraclavicular nodal metastases (cN3c) were downstaged from AJCC stage IV to IIIc, prompting management with locoregional treatment. We sought to estimate the impact of multimodal therapy on overall surviva ... Full text Link to item Cite

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.

Journal Article Nat Mater · April 2021 Stromal stiffening accompanies malignancy, compromises treatment and promotes tumour aggression. Clarifying the molecular nature and the factors that regulate stromal stiffening in tumours should identify biomarkers to stratify patients for therapy and int ... Full text Link to item Cite

Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling.

Journal Article Nat Commun · March 25, 2021 Activating intra-tumor innate immunity might enhance tumor immune surveillance. Virotherapy is proposed to achieve tumor cell killing, while indirectly activating innate immunity. Here, we report that recombinant poliovirus therapy primarily mediates antit ... Full text Link to item Cite

Patient-reported causes of distress predict disparities in time to evaluation and time to treatment after breast cancer diagnosis.

Journal Article Cancer · March 1, 2021 BACKGROUND: We examined whether the National Comprehensive Cancer Network distress thermometer (DT), a patient-reported outcome measure, could be used to identify levels and causes of distress associated with racial/ethnic disparities in time to care among ... Full text Link to item Cite

Unmasking the immune microecology of ductal carcinoma in situ with deep learning.

Journal Article NPJ Breast Cancer · March 1, 2021 Despite increasing evidence supporting the clinical relevance of tumour infiltrating lymphocytes (TILs) in invasive breast cancer, TIL spatial variability within ductal carcinoma in situ (DCIS) samples and its association with progression are not well unde ... Full text Open Access Link to item Cite

Electronic Health Record Use by Sex Among Physicians in an Academic Health Care System.

Journal Article JAMA Intern Med · February 1, 2021 This cohort study examines the association of sex with electronic health record use among physicians and patient satisfaction. ... Full text Link to item Cite

Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic.

Journal Article The British journal of surgery · January 2021 BackgroundSurgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective can ... Full text Open Access Cite

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

Journal Article J Clin Oncol · January 1, 2021 PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with ... Full text Link to item Cite

A stiff stroma stimulates inflammation to promote breast tumor progression

Conference INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY · 2021 Cite

Impact of adjuvant trastuzumab on locoregional failure rates in a randomized clinical trial: North Central Cancer Treatment Group N9831 (alliance) study.

Journal Article Cancer · December 15, 2020 BACKGROUND: The goal of this study was to assess the impact of trastuzumab on locoregional failure. METHODS: The analysis included 2763 patients with HER2-positive (HER2+) breast cancer who were randomly assigned to adjuvant doxorubicin (A), cyclophosphami ... Full text Link to item Cite

Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.

Journal Article J Clin Invest · November 2, 2020 Women with dense breasts have an increased lifetime risk of malignancy that has been attributed to a higher epithelial density. Quantitative proteomics, collagen analysis, and mechanical measurements in normal tissue revealed that stroma in the high-densit ... Full text Link to item Cite

Predicting Upstaging of DCIS to Invasive Disease: Radiologists's Predictive Performance.

Journal Article Acad Radiol · November 2020 RATIONALE AND OBJECTIVES: The purpose of this study is to quantify breast radiologists' performance at predicting occult invasive disease when ductal carcinoma in situ (DCIS) presents as calcifications on mammography and to identify imaging and histopathol ... Full text Link to item Cite

Do Histopathology and Clinical Outcomes of Breast Atypia Vary by Race/Ethnicity?

Journal Article J Surg Res · November 2020 BACKGROUND: The clinical behavior of breast cancer varies by racial and ethnic makeup (REM), but the impact of REM on the clinical outcomes of breast atypia remains understudied. We examined the impact of REM on risk of underlying or subsequent carcinoma f ... Full text Link to item Cite

Surgery for Men with Breast Cancer: Do the Same Data Still Apply?

Journal Article Ann Surg Oncol · November 2020 BACKGROUND: Men represent a small proportion of breast cancer diagnoses, and they are often excluded from clinical trials. Current treatments are largely extrapolated from evidence in women. We compare practice patterns between men and women with breast ca ... Full text Link to item Cite

It's not you, It's me: The influence of patient and surgeon gender on patient satisfaction scores.

Journal Article Am J Surg · November 2020 BACKGROUND: Surgeons face the unique challenge of being responsible for both clinical encounters and surgical outcomes. We aim to explore how patient evaluations of surgeons may be influenced by patient and provider factors. METHODS: Patient responses from ... Full text Link to item Cite

A medicare-based comparative mortality analysis of active surveillance in older women with DCIS.

Journal Article NPJ Breast Cancer · October 30, 2020 Over 97% of individuals diagnosed with ductal carcinoma in situ (DCIS) will choose to receive guideline concordant care (GCC), which was originally designed to treat invasive cancers and is associated with treatment related morbidity. An alternative to GCC ... Full text Link to item Cite

Association of Smartphone Ownership and Internet Use With Markers of Health Literacy and Access: Cross-sectional Survey Study of Perspectives From Project PLACE (Population Level Approaches to Cancer Elimination) (Preprint)

Journal Article · October 11, 2020 BACKGROUNDTelehealth is an increasingly important component of health care delivery in response to the COVID-19 pandemic. However, well-documented disparities persist in the use of digita ... Full text Cite

Surgical Management of the Axilla in Elderly Women With Node-Positive Breast Cancer.

Journal Article J Surg Res · October 2020 BACKGROUND: Elderly women with clinically node-positive (cN+) breast cancer (BC) often have comorbidities that limit life expectancy and complicate treatment. We sought to determine whether the number of lymph nodes (LNs) retrieved among older women with n ... Full text Link to item Cite

Surgeons, plague, and leadership: A historical mantle to carry forward.

Journal Article Am J Surg · August 2020 • Surgeons have a long tradition of leading research into pandemics. • Examples include Guy de Chauliac, James Lind, John Snow, John Hunter, Walter Reed. • We should leverage this history to lead efforts fighting COVID-19. ... Full text Link to item Cite

Surgical Oncologists and the COVID-19 Pandemic: Guiding Cancer Patients Effectively through Turbulence and Change.

Journal Article Ann Surg Oncol · August 2020 BACKGROUND: The COVID-19 pandemic has posed extraordinary demands from patients, providers, and health care systems. Despite this, surgical oncologists must maintain focus on providing high-quality, empathetic care for the almost 2 million patients nationa ... Full text Link to item Cite

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study.

Journal Article Lancet · July 4, 2020 BACKGROUND: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmo ... Full text Link to item Cite

Overall health at diagnosis predicts the risk of complications within the first year after breast cancer diagnosis.

Journal Article Breast Cancer Res Treat · July 2020 PURPOSE: Breast cancer patients with overall poor health are at a greater risk of both complications during treatment and mortality from competing causes. We sought to determine the association of pre-existing comorbidities on treatment-related complicatio ... Full text Link to item Cite

Prediction of Upstaged Ductal Carcinoma In Situ Using Forced Labeling and Domain Adaptation.

Journal Article IEEE Trans Biomed Eng · June 2020 OBJECTIVE: The goal of this study is to use adjunctive classes to improve a predictive model whose performance is limited by the common problems of small numbers of primary cases, high feature dimensionality, and poor class separability. Specifically, our ... Full text Link to item Cite

Phase II Single-Arm Study of Preoperative Letrozole for Estrogen Receptor-Positive Postmenopausal Ductal Carcinoma In Situ: CALGB 40903 (Alliance).

Journal Article J Clin Oncol · April 20, 2020 PURPOSE: Primary endocrine therapy for ductal carcinoma in situ (DCIS) as a potential alternative to surgery has been understudied. This trial explored the feasibility of a short-term course of letrozole and sought to determine whether treatment results in ... Full text Link to item Cite

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.

Journal Article Cell · April 16, 2020 Crucial transitions in cancer-including tumor initiation, local expansion, metastasis, and therapeutic resistance-involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial mu ... Full text Open Access Link to item Cite

Pain Control in Breast Surgery: Survey of Current Practice and Recommendations for Optimizing Management-American Society of Breast Surgeons Opioid/Pain Control Workgroup.

Journal Article Ann Surg Oncol · April 2020 INTRODUCTION: The opioid epidemic in the United States is a public health crisis. Breast surgeons are obligated to provide good pain control for their patients after surgery but also must minimize administration of narcotics to prevent a surgical episode o ... Full text Link to item Cite

A Case-Control Study Examining Disparities in Clinical Trial Participation Among Breast Surgical Oncology Patients.

Journal Article JNCI Cancer Spectr · April 2020 BACKGROUND: Clinical trial participation among racial and ethnic minorities remains low despite national efforts. We sought to determine how participation in clinical trials by breast surgical oncology patients has changed over time and what characteristic ... Full text Link to item Cite

Minimal barriers to invasion during human colorectal tumor growth.

Journal Article Nat Commun · March 9, 2020 Intra-tumoral heterogeneity (ITH) could represent clonal evolution where subclones with greater fitness confer more malignant phenotypes and invasion constitutes an evolutionary bottleneck. Alternatively, ITH could represent branching evolution with invasi ... Full text Link to item Cite

Preanalytical Variables for the Genomic Assessment of the Cellular and Acellular Fractions of the Liquid Biopsy in a Cohort of Breast Cancer Patients.

Journal Article J Mol Diagn · March 2020 Liquid biopsy allows assessment of multiple analytes, providing temporal information with potential for improving understanding of cancer evolution and clinical management of patients. Although liquid biopsies are intensely investigated for prediction and ... Full text Link to item Cite

The Evolution of Breast Satisfaction and Well-Being after Breast Cancer: A Propensity-Matched Comparison to the Norm.

Journal Article Plast Reconstr Surg · March 2020 BACKGROUND: Breast cancer survival continues to improve, with women living longer after treatment. It is not well understood how long-term satisfaction and well-being differ following treatment or how types of reconstruction differ when compared to the nor ... Full text Link to item Cite

Abstract P3-08-10: Characterization of oncotype DX recurrence score and chemotherapy utilization patterns in young women (≤40) with early stage ER+/HER-, lymph node negative breast cancer

Conference Cancer Research · February 15, 2020 AbstractBackground: Meta-analyses have demonstrated that young women ≤40 (YW) derive the most benefit from chemotherapy (EBCTCG, Lancet. 1998). Oncotype DX was designed to determine the benefit of chemothera ... Full text Cite

Abstract P5-14-17: Musculoskeletal side effects over time and association with adherence in women taking neoadjuvant letrozole for estrogen receptor positive DCIS: CALGB 40903 (Alliance)

Conference Cancer Research · February 15, 2020 AbstractBackground: Side effects of and adherence to aromatase inhibitors in women with ductal carcinoma in situ are not well described. Methods: Postmenopausal women in a prospective phase II study of neoad ... Full text Cite

Abstract P1-21-07: The Patient-reported Outcomes after Routine Treatment of Atypical Lesions (PORTAL) study: Pain, psychosocial wellbeing, and quality of life among women undergoing guideline concordant care for DCIS vs. active surveillance for in situ and atypical lesions

Conference Cancer Research · February 15, 2020 AbstractBackground: Guideline-concordant care (GCC) for DCIS includes surgery, radiation, and endocrine treatment. Active surveillance (AS) is a strategy under study for management of low risk DCIS. The PORT ... Full text Cite

Axillary lymph node dissection in node-positive breast cancer: are ten nodes adequate and when is enough, enough?

Conference Breast Cancer Res Treat · February 2020 PURPOSE: National guidelines define adequate axillary lymph node dissections as those yielding ≥ 10 lymph nodes (LNs). We aimed to identify the optimal LN yield among node-positive patients. METHODS: Using the National Cancer Data Base (2010-2015), we cate ... Full text Link to item Cite

Breast cancer tumor histopathology, stage at presentation, and treatment in the extremes of age.

Conference Breast Cancer Res Treat · February 2020 BACKGROUND: Given presumed differences in disease severity between young (≤ 45 years) and elderly (≥ 75 years) women with breast cancer, we sought to compare tumor histopathology, stage at presentation, patterns of care, and survival at the extremes of age ... Full text Link to item Cite

Response to Habel and Buist.

Journal Article J Natl Cancer Inst · February 1, 2020 Full text Link to item Cite

Nodal Response to Neoadjuvant Chemotherapy Predicts Receipt of Radiation Therapy After Breast Cancer Diagnosis.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2020 BACKGROUND: Pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT) is associated with improved overall survival (OS) in patients with breast cancer, but it is unclear how post-NACT response influences radiation therapy administration in p ... Full text Open Access Link to item Cite

Extent of axillary surgery in inflammatory breast cancer: a survival analysis of 3500 patients.

Journal Article Breast Cancer Res Treat · February 2020 PURPOSE: Inflammatory breast cancer (IBC) is an aggressive variant for which axillary lymph node (LN) dissection following neoadjuvant chemotherapy (NACT) remains standard of care. But with increasingly effective systemic therapy, it is unclear whether mor ... Full text Link to item Cite

Implications for Breast Cancer Restaging Based on the 8th Edition AJCC Staging Manual.

Journal Article Ann Surg · January 2020 OBJECTIVE: We assessed the changes that have resulted from the latest breast cancer staging guidelines and the potential impact on prognosis. BACKGROUND: Contemporary data suggest that combining anatomic staging and tumor biology yields a predictive synerg ... Full text Link to item Cite

Microcalcification localization and cluster detection using unsupervised convolutional autoencoders and structural similarity index

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 Detecting microcalcification clusters in mammograms is important to the diagnosis of breast diseases. Previous studies which mainly focused on supervised methods require abundant annotated training data but these data are usually hard to acquire. In this w ... Full text Cite

A multitask deep learning method in simultaneously predicting occult invasive disease in ductal carcinoma in-situ and segmenting microcalcifications in mammography

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 We proposed a two-branch multitask learning convolutional neural network to solve two different but related tasks at the same time. Our main task is to predict occult invasive disease in biopsy proven Ductal Carcinoma in-situ (DCIS), with an auxiliary task ... Full text Cite

A medicare-based comparative mortality analysis of active surveillance in older women with DCIS.

Journal Article NPJ Breast Cancer · 2020 Over 97% of individuals diagnosed with ductal carcinoma in situ (DCIS) will choose to receive guideline concordant care (GCC), which was originally designed to treat invasive cancers and is associated with treatment related morbidity. An alternative to GCC ... Full text Link to item Cite

Derivation of a nuclear heterogeneity image index to grade DCIS.

Journal Article Comput Struct Biotechnol J · 2020 Abnormalities in cell nuclear morphology are a hallmark of cancer. Histological assessment of cell nuclear morphology is frequently used by pathologists to grade ductal carcinoma in situ (DCIS). Objective methods that allow standardization and reproducibil ... Full text Link to item Cite

Deep learning analysis of breast MRIs for prediction of occult invasive disease in ductal carcinoma in situ.

Journal Article Comput Biol Med · December 2019 PURPOSE: To determine whether deep learning-based algorithms applied to breast MR images can aid in the prediction of occult invasive disease following the diagnosis of ductal carcinoma in situ (DCIS) by core needle biopsy. MATERIALS AND METHODS: Our study ... Full text Link to item Cite

Estimating the magnitude of clinical benefit of local therapy in patients with DCIS.

Journal Article Breast · November 2019 DCIS represents a heterogeneous disease with a wide range of outcomes according to biology. Without treatment, it is estimated that only 20-30% of DCIS will progress to invasive cancer. Long-term outcomes following treatment are at least as favorable as th ... Full text Link to item Cite

Decreasing rates of axillary lymph node dissections over time: Implications for surgical resident exposure and operative skills development.

Conference Am J Surg · October 2019 BACKGROUND: Sentinel lymph node biopsy has supplanted axillary lymph node dissection (ALND) in clinically node-negative breast cancer and select node-positive disease. We hypothesized a decreasing rate of both ALND and resident exposure over time. METHODS: ... Full text Link to item Cite

DCIS with Microinvasion: Is It In Situ or Invasive Disease?

Conference Ann Surg Oncol · October 2019 BACKGROUND: Ductal carcinoma in situ (DCIS) with microinvasion (DCISM) can be challenging in balancing the risks of overtreatment versus undertreatment. We compared DCISM, pure DCIS, and small volume (T1a) invasive ductal carcinoma (IDC) as related to hist ... Full text Link to item Cite

Neoadjuvant Endocrine Therapy Versus Neoadjuvant Chemotherapy in Node-Positive Invasive Lobular Carcinoma.

Conference Ann Surg Oncol · October 2019 BACKGROUND: Neoadjuvant chemotherapy (NACT) is often recommended for patients with node-positive invasive lobular carcinoma (ILC) despite unclear benefit in this largely hormone receptor-positive (HR+) group. We sought to compare overall survival (OS) betw ... Full text Link to item Cite

Perspectives on the Costs of Cancer Care: A Survey of the American Society of Breast Surgeons.

Conference Ann Surg Oncol · October 2019 BACKGROUND: Cancer treatment costs are not routinely addressed in shared decisions for breast cancer surgery. Thus, we sought to characterize cost awareness and communication among surgeons treating breast cancer. METHODS: We conducted a self-administered, ... Full text Link to item Cite

Clinical and pathological stage discordance among 433,514 breast cancer patients.

Journal Article Am J Surg · October 2019 BACKGROUND: We aim to determine clinical and pathological stage discordance rates and to evaluate factors associated with discordance. METHODS: Adults with clinical stages I-III breast cancer were identified from the National Cancer Data Base. Concordance ... Full text Open Access Link to item Cite

Ductal Carcinoma In Situ Management: All or Nothing, or Something in between?

Journal Article Current Breast Cancer Reports · September 15, 2019 Purpose of Review: Standard treatment for ductal carcinoma in situ (DCIS) is similar to that of invasive carcinoma. However, there is significant controversy regarding the true clinical implications of DCIS, and thus, the best management strategy. The aim ... Full text Cite

Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ.

Journal Article Nat Commun · September 13, 2019 Myoepithelial cells play key roles in normal mammary gland development and in limiting pre-invasive to invasive breast tumor progression, yet their differentiation and perturbation in ductal carcinoma in situ (DCIS) are poorly understood. Here, we investig ... Full text Link to item Cite

Variability in diagnostic threshold for comedo necrosis among breast pathologists: implications for patient eligibility for active surveillance trials of ductal carcinoma in situ.

Conference Mod Pathol · September 2019 Active surveillance trials for low-risk ductal carcinoma in situ (DCIS) are in progress in the United States and Europe. In some of these trials, the presence of comedo necrosis in the DCIS has been an exclusion criterion for trial entry. However, the mini ... Full text Link to item Cite

Cancer Outcomes in DCIS Patients Without Locoregional Treatment.

Journal Article J Natl Cancer Inst · September 1, 2019 BACKGROUND: The vast majority of women diagnosed with ductal carcinoma in situ (DCIS) undergo treatment. Therefore, the risks of invasive progression and competing death in the absence of locoregional therapy are uncertain. METHODS: We performed survival a ... Full text Link to item Cite

The Influence of Age on the Histopathology and Prognosis of Atypical Breast Lesions.

Journal Article J Surg Res · September 2019 BACKGROUND: Although several prognostic variables and risk factors for breast cancer are age-related, the association between age and risk of cancer with breast atypia is controversial. This study aimed to compare the type of breast atypia and risk of unde ... Full text Open Access Link to item Cite

The effect of treatment on patient-reported distress after breast cancer diagnosis.

Journal Article Cancer · September 1, 2019 BACKGROUND: The National Comprehensive Cancer Network (NCCN) Distress Thermometer (DT) uses a 10-point scale (in which 0 indicates no distress and 10 indicates extreme distress) to measure patient-reported distress. In the current study, the authors sought ... Full text Link to item Cite

Synchronous Detection of Circulating Tumor Cells in Blood and Disseminated Tumor Cells in Bone Marrow Predicts Adverse Outcome in Early Breast Cancer.

Journal Article Clin Cancer Res · September 1, 2019 PURPOSE: We examined the prognostic impact of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) detected at the time of surgery in 742 untreated patients with early breast cancer. EXPERIMENTAL DESIGN: DTCs in bone marrow were enumerated us ... Full text Link to item Cite

Impact of Adjuvant Trastuzumab on Locoregional Failure Rates in the NCCTG N9831 (Alliance) Study

Conference International Journal of Radiation Oncology*Biology*Physics · September 2019 Full text Cite

The impact of chemotherapy sequence on survival in node-positive invasive lobular carcinoma.

Journal Article J Surg Oncol · August 2019 BACKGROUND AND OBJECTIVES: We sought to evaluate the impact of chemotherapy sequence on survival by comparing node-positive invasive lobular carcinoma (ILC) patients who received neoadjuvant (NACT) and adjuvant (ACT) chemotherapy. METHODS: cT1-4c, cN1-3 IL ... Full text Open Access Link to item Cite

Incidence of Ductal Carcinoma In Situ in the United States, 2000-2014.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2019 BACKGROUND: In absence of definitive molecular risk markers, clinical management of patients diagnosed with ductal carcinoma in situ (DCIS) remains largely guided by patient and tumor characteristics. In this study, we analyzed recent trends in DCIS incide ... Full text Link to item Cite

Ductal carcinoma in situ: to treat or not to treat, that is the question.

Journal Article Br J Cancer · August 2019 Ductal carcinoma in situ (DCIS) now represents 20-25% of all 'breast cancers' consequent upon detection by population-based breast cancer screening programmes. Currently, all DCIS lesions are treated, and treatment comprises either mastectomy or breast-con ... Full text Link to item Cite

Financial Costs and Burden Related to Decisions for Breast Cancer Surgery.

Journal Article J Oncol Pract · August 2019 PURPOSE: Financial toxicity is a well-recognized adverse effect of cancer care, yet little is known about how women consider treatment costs when facing preference-sensitive decisions for breast cancer surgery or how surgical treatment choice affects finan ... Full text Link to item Cite

Growth Dynamics of Mammographic Calcifications: Differentiating Ductal Carcinoma in Situ from Benign Breast Disease.

Journal Article Radiology · July 2019 Background Most ductal carcinoma in situ (DCIS) lesions are first detected on screening mammograms as calcifications. However, false-positive biopsy rates for calcifications range from 30% to 87%. Improved methods to differentiate benign from malignant cal ... Full text Link to item Cite

Abstract CT220: Expansion into multiple institutions for training in the use of the LUM Imaging System for intraoperative detection of residual cancer in the tumor bed of female subjects with breast cancer

Conference Cancer Research · July 1, 2019 AbstractBackground: Obtaining tumor-free margins is critical for local control in breast conserving surgery. Currently, 20-40% of lumpectomy patients have positive margins that require surgical re-excision; ... Full text Cite

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets.

Journal Article Cancer Cell · April 15, 2019 The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human cancer are poorly understood. Here, we show that monocyte subpopulation distribution and transcriptomes are significantly altered by the presence of endometrial and breast ... Full text Link to item Cite

The COMET (Comparison of Operative versus Monitoring and Endocrine Therapy) trial: a phase III randomised controlled clinical trial for low-risk ductal carcinoma in situ (DCIS).

Journal Article BMJ Open · March 12, 2019 INTRODUCTION: Ductal carcinoma in situ (DCIS) is a non-invasive non-obligate precursor of invasive breast cancer. With guideline concordant care (GCC), DCIS outcomes are at least as favourable as some other early stage cancer types such as prostate cancer, ... Full text Link to item Cite

Surgical Resection of the Primary Tumor in Women With De Novo Stage IV Breast Cancer: Contemporary Practice Patterns and Survival Analysis.

Journal Article Ann Surg · March 2019 OBJECTIVE: We evaluated patterns of surgical care and their association with overall survival among a contemporary cohort of women with stage IV breast cancer. BACKGROUND: Surgical resection of the primary tumor remains controversial among women with stage ... Full text Link to item Cite

A National Snapshot of Patient-Reported Outcomes Comparing Types of Abdominal Flaps for Breast Reconstruction.

Journal Article Plast Reconstr Surg · March 2019 BACKGROUND: This study aimed to identify differences in patient-reported abdominal well-being, satisfaction, and quality of life in women with muscle-preserving free abdominal versus pedicle transverse rectus abdominis musculocutaneous (TRAM) flap for brea ... Full text Link to item Cite

Abstract PD6-08: Medicare costs for women after breast cancer: Preparing for survivorship

Conference Cancer Research · February 15, 2019 AbstractBACKGROUNDImprovements in breast cancer survival and increasing population life expectancy have resulted in a growing number of women receiving subsequent health care ... Full text Cite

Reframing the conversation about contralateral prophylactic mastectomy: Preparing women for postsurgical realities.

Conference Psychooncology · February 2019 OBJECTIVE: Women with unilateral, early-stage breast cancer and low genetic risk are increasingly opting for contralateral prophylactic mastectomy (CPM), a concerning trend because CPM offers few clinical benefits while increasing risks of surgical complic ... Full text Link to item Cite

Risk factors for severe acute pain and persistent pain after surgery for breast cancer: a prospective observational study.

Journal Article Reg Anesth Pain Med · February 2019 BACKGROUND AND OBJECTIVES: There are few prospective studies providing comprehensive assessment of risk factors for acute and persistent pain after breast surgery. This prospective observational study assessed patient-related, perioperative, and genetic ri ... Full text Link to item Cite

Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA.

Journal Article Circulation · January 15, 2019 BACKGROUND: Individuals with type 2 diabetes mellitus are at increased risk for heart failure (HF), particularly those with coexisting atherosclerotic cardiovascular disease and/or kidney disease. Some but not all dipeptidyl peptidase-4 inhibitors have bee ... Full text Link to item Cite

Identification of the Fraction of Indolent Tumors and Associated Overdiagnosis in Breast Cancer Screening Trials.

Journal Article Am J Epidemiol · January 1, 2019 It is generally accepted that some screen-detected breast cancers are overdiagnosed and would not progress to symptomatic cancer if left untreated. However, precise estimates of the fraction of nonprogressive cancers remain elusive. In recognition of the w ... Full text Link to item Cite

Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial.

Journal Article JAMA · January 1, 2019 IMPORTANCE: Type 2 diabetes is associated with increased cardiovascular (CV) risk. Prior trials have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included limited numbers of patients with high CV risk and chronic kidney di ... Full text Link to item Cite

Perspectives on Inflammatory Breast Cancer (IBC) Research, Clinical Management and Community Engagement from the Duke IBC Consortium.

Journal Article J Cancer · 2019 Inflammatory breast cancer (IBC) is an understudied and aggressive form of breast cancer with a poor prognosis, accounting for 2-6% of new breast cancer diagnoses but 10% of all breast cancer-related deaths in the United States. Currently there are no ther ... Full text Open Access Link to item Cite

Malignant microcalcification clusters detection using unsupervised deep autoencoders

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2019 Detection and localization of microcalcification (MC) clusters are very important in mammography diagnosis. Supervised MC detectors require learning from extracted individual MCs and MC clusters. However, they are limited by number of datasets given that M ... Full text Cite

Examining Peripheral and Tumor Cellular Immunome in Patients With Cancer.

Journal Article Front Immunol · 2019 Immunotherapies are rapidly being integrated into standard of care (SOC) therapy in conjunction with surgery, chemotherapy, and radiotherapy for many cancers and a large number of clinical studies continue to explore immunotherapy alone and as part of comb ... Full text Link to item Cite

Simulation Modeling of Cancer Clinical Trials: Application to Omitting Radiotherapy in Low-risk Breast Cancer.

Journal Article J Natl Cancer Inst · December 1, 2018 BACKGROUND: We used two models to simulate a proposed noninferiority trial of radiotherapy (RT) omission in low-risk invasive breast cancer to illustrate how modeling could be used to predict the trial's outcomes, inform trial design, and contribute to pra ... Full text Link to item Cite

Association of Low Nodal Positivity Rate Among Patients With ERBB2-Positive or Triple-Negative Breast Cancer and Breast Pathologic Complete Response to Neoadjuvant Chemotherapy.

Journal Article JAMA Surg · December 1, 2018 IMPORTANCE: A recent publication reported that of 527 patients with clinically node-negative (cN0) cT1/cT2 triple-negative breast cancer (TNBC) or ERBB2-positive disease treated with neoadjuvant chemotherapy (NAC), 100% of those who achieved a breast patho ... Full text Link to item Cite

Intra-tumor molecular heterogeneity in breast cancer: definitions of measures and association with distant recurrence-free survival.

Journal Article Breast Cancer Res Treat · November 2018 PURPOSE: The purpose of the study was to define quantitative measures of intra-tumor heterogeneity in breast cancer based on histopathology data gathered from multiple samples on individual patients and determine their association with distant recurrence-f ... Full text Link to item Cite

Financial Burden Related to Decisions for Breast Cancer Surgery

Conference JOURNAL OF WOMENS HEALTH · November 1, 2018 Link to item Cite

Axillary Nodal Evaluation in Elderly Breast Cancer Patients: Potential Effects on Treatment Decisions and Survival.

Conference Ann Surg Oncol · October 2018 BACKGROUND: Recent studies suggest that surgical lymph node (LN) evaluation may be omitted in select elderly breast cancer patients as it may not influence adjuvant therapy decisions. To evaluate differences in adjuvant therapy receipt and overall survival ... Full text Link to item Cite

The Association of Extent of Axillary Surgery and Survival in Women with N2-3 Invasive Breast Cancer.

Journal Article Ann Surg Oncol · October 2018 BACKGROUND: Although surgical management of the axilla for breast cancer continues to evolve, axillary lymphadenectomy remains the standard of care for women with advanced nodal disease. We sought to evaluate national patterns of care in axillary surgery, ... Full text Link to item Cite

The Changing Paradigms for Breast Cancer Surgery: Performing Fewer and Less-Invasive Operations.

Journal Article Ann Surg Oncol · October 2018 Historically, through the conduct of prospective clinical trials, breast cancer surgeons have performed less radical breast and axillary surgeries with no survival decrement to our patients. Currently, other opportunities exist for the treating breast surg ... Full text Link to item Cite

The Clinical Significance of Breast-only and Node-only Pathologic Complete Response (pCR) After Neoadjuvant Chemotherapy (NACT): A Review of 20,000 Breast Cancer Patients in the National Cancer Data Base (NCDB).

Journal Article Ann Surg · October 2018 OBJECTIVE: To determine whether the association between overall survival (OS) and response to neoadjuvant chemotherapy (NACT) in breast cancer patients varies with tumor subtype and anatomic extent of pathologic complete response (pCR). BACKGROUND: pCR aft ... Full text Link to item Cite

Metaplastic Breast Cancer Treatment and Outcomes in 2500 Patients: A Retrospective Analysis of a National Oncology Database.

Journal Article Ann Surg Oncol · August 2018 BACKGROUND: Metaplastic breast cancer (MBC) is characterized by chemoresistance and hematogenous spread. We sought to identify factors associated with improved MBC outcomes and increased likelihood of MBC diagnosis. METHODS: Women ≥ 18 years of age with st ... Full text Link to item Cite

Pediatric phyllodes tumors: A review of the National Cancer Data Base and adherence to NCCN guidelines for phyllodes tumor treatment.

Journal Article J Pediatr Surg · June 2018 BACKGROUND: Phyllodes tumors are fibroepithelial breast lesions that are uncommon in women and rare among children. Due to scarcity, few large pediatric phyllodes tumor series exist. Current guidelines do not differentiate treatment recommendations between ... Full text Link to item Cite

Extent of axillary surgery in women with Stage IV breast cancer

Conference ANNALS OF SURGICAL ONCOLOGY · June 1, 2018 Link to item Cite

Prediction of Occult Invasive Disease in Ductal Carcinoma in Situ Using Deep Learning Features.

Journal Article J Am Coll Radiol · March 2018 PURPOSE: The aim of this study was to determine whether deep features extracted from digital mammograms using a pretrained deep convolutional neural network are prognostic of occult invasive disease for patients with ductal carcinoma in situ (DCIS) on core ... Full text Link to item Cite

The Effect of Hospital Volume on Breast Cancer Mortality.

Journal Article Ann Surg · February 2018 OBJECTIVE: The aim of this study was to determine whether hospital volume was associated with mortality in breast cancer, and what thresholds of case volume impacted survival. BACKGROUND: Prior literature has demonstrated improved survival with treatment a ... Full text Link to item Cite

Trends and variations in postmastectomy radiation therapy for breast cancer in patients with 1 to 3 positive lymph nodes: A National Cancer Data Base analysis.

Journal Article Cancer · February 1, 2018 BACKGROUND: High-level evidence is lacking to guide treatment decisions about postmastectomy radiation therapy (PMRT) in patients who have breast cancer with 1 to 3 positive lymph nodes who receive contemporary systemic therapies, leading to potential vari ... Full text Link to item Cite

Anatomy and Breast Cancer Staging: Is It Still Relevant?

Journal Article Surg Oncol Clin N Am · January 2018 Breast cancer staging concisely summarizes disease status, creating a framework for assessing and relaying prognostic information. The fundamental concepts and components of breast cancer staging are reviewed. The AJCC Cancer Staging Manual, which includes ... Full text Link to item Cite

Molecular determinants of post-mastectomy breast cancer recurrence.

Conference NPJ Breast Cancer · 2018 Breast cancer (BC) adjuvant therapy after mastectomy in the setting of 1-3 positive lymph nodes has been controversial. This retrospective Translational Breast Cancer Research Consortium study evaluated molecular aberrations in primary cancers associated w ... Full text Link to item Cite

Learning better deep features for the prediction of occult invasive disease in ductal carcinoma in situ through transfer learning

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 Purpose: To determine whether domain transfer learning can improve the performance of deep features extracted from digital mammograms using a pre-trained deep convolutional neural network (CNN) in the prediction of occult invasive disease for patients with ... Full text Cite

Deep learning-based features of breast MRI for prediction of occult invasive disease following a diagnosis of ductal carcinoma in situ: Preliminary data

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 Approximately 25% of patients with ductal carcinoma in situ (DCIS) diagnosed from core needle biopsy are subsequently upstaged to invasive cancer at surgical excision. Identifying patients with occult invasive disease is important as it changes treatment a ... Full text Cite

Improving classification with forced labeling of other related classes: Application to prediction of upstaged ductal carcinoma in situ using mammographic features

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 Predicting whether ductal carcinoma in situ (DCIS) identified at core biopsy contains occult invasive disease is an import task since these "upstaged" cases will affect further treatment planning. Therefore, a prediction model that better classifies pure D ... Full text Cite

Indications and techniques for biopsy

Chapter · January 1, 2018 Several breast biopsy techniques are available for patients presenting with palpable and nonpalpable lesions. Current consensus guidelines recommend percutaneous biopsy as the initial tissue acquisition modality. Image guidance (ultrasound, mammogram, or m ... Full text Cite

The Impact of Autologous Breast Reconstruction on Body Mass Index Patterns in Breast Cancer Patients: A Propensity-Matched Analysis.

Journal Article Plast Reconstr Surg · December 2017 BACKGROUND: Weight gain is common in breast cancer patients and increases the risk of recurrence and mortality. The authors assessed the impact of autologous breast reconstruction on body mass index patterns after diagnosis in mastectomy patients. METHODS: ... Full text Link to item Cite

Can algorithmically assessed MRI features predict which patients with a preoperative diagnosis of ductal carcinoma in situ are upstaged to invasive breast cancer?

Journal Article J Magn Reson Imaging · November 2017 PURPOSE: To assess the ability of algorithmically assessed magnetic resonance imaging (MRI) features to predict the likelihood of upstaging to invasive cancer in newly diagnosed ductal carcinoma in situ (DCIS). MATERIALS AND METHODS: We identified 131 pati ... Full text Link to item Cite

Imaging Features of Patients Undergoing Active Surveillance for Ductal Carcinoma in Situ.

Journal Article Acad Radiol · November 2017 RATIONALE AND OBJECTIVES: The aim of this study was to describe the imaging appearance of patients undergoing active surveillance for ductal carcinoma in situ (DCIS). MATERIALS AND METHODS: We retrospectively identified 29 patients undergoing active survei ... Full text Link to item Cite

Surgical Upstaging Rates for Vacuum Assisted Biopsy Proven DCIS: Implications for Active Surveillance Trials.

Journal Article Ann Surg Oncol · November 2017 PURPOSE: This study was designed to determine invasive cancer upstaging rates at surgical excision following vacuum-assisted biopsy of ductal carcinoma in situ (DCIS) among women meeting eligibility for active surveillance trials. METHODS: Patients with va ... Full text Link to item Cite

Patient Age and Tumor Subtype Predict the Extent of Axillary Surgery Among Breast Cancer Patients Eligible for the American College of Surgeons Oncology Group Trial Z0011.

Journal Article Ann Surg Oncol · November 2017 BACKGROUND: The American College of Surgeons Oncology Group (ACOSOG) Z0011 trial established the safety of omitting axillary lymph node dissection (ALND) for early-stage breast cancer patients with limited nodal disease undergoing lumpectomy. We examined t ... Full text Link to item Cite

Fat Grafting-More Than Just the Hype.

Journal Article JAMA Surg · October 1, 2017 Full text Link to item Cite

Cost Effectiveness of Risk-Reducing Mastectomy versus Surveillance in BRCA Mutation Carriers with a History of Ovarian Cancer.

Journal Article Ann Surg Oncol · October 2017 BACKGROUND: The appropriate management of breast cancer risk in BRCA mutation carriers following ovarian cancer diagnosis remains unclear. We sought to determine the survival benefit and cost effectiveness of risk-reducing mastectomy (RRM) among women with ... Full text Link to item Cite

Classifying the evolutionary and ecological features of neoplasms.

Journal Article Nat Rev Cancer · October 2017 Neoplasms change over time through a process of cell-level evolution, driven by genetic and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic cell determines which changes provide adaptive benefits. There is widespread re ... Full text Link to item Cite

Can Occult Invasive Disease in Ductal Carcinoma In Situ Be Predicted Using Computer-extracted Mammographic Features?

Journal Article Acad Radiol · September 2017 RATIONALE AND OBJECTIVES: This study aimed to determine whether mammographic features assessed by radiologists and using computer algorithms are prognostic of occult invasive disease for patients showing ductal carcinoma in situ (DCIS) only in core biopsy. ... Full text Link to item Cite

The Financial Burden of Breast Cancer Treatment

Conference JOURNAL OF WOMENS HEALTH · September 1, 2017 Link to item Cite

Reporting and Guidelines in Propensity Score Analysis: A Systematic Review of Cancer and Cancer Surgical Studies.

Journal Article J Natl Cancer Inst · August 1, 2017 BACKGROUND: : Propensity score (PS) analysis is increasingly being used in observational studies, especially in some cancer studies where random assignment is not feasible. This systematic review evaluates the use and reporting quality of PS analysis in on ... Full text Link to item Cite

Suspicious breast calcifications undergoing stereotactic biopsy in women ages 70 and over: Breast cancer incidence by BI-RADS descriptors.

Journal Article Eur Radiol · June 2017 OBJECTIVES: To determine the malignancy rate overall and for specific BI-RADS descriptors in women ≥70 years who undergo stereotactic biopsy for calcifications. METHODS: We retrospectively reviewed 14,577 consecutive mammogram reports in 6839 women ≥70 yea ... Full text Link to item Cite

Breast Cancer after Augmentation: Oncologic and Reconstructive Considerations among Women Undergoing Mastectomy.

Journal Article Plast Reconstr Surg · June 2017 BACKGROUND: Breast augmentation with subglandular versus subpectoral implants may differentially impact the early detection of breast cancer and treatment recommendations. The authors assessed the impact of prior augmentation on the diagnosis and managemen ... Full text Link to item Cite

Reply to L.B. Marks et al.

Journal Article J Clin Oncol · April 10, 2017 Full text Link to item Cite

Cost Implications of an Evidence-Based Approach to Radiation Treatment After Lumpectomy for Early-Stage Breast Cancer.

Journal Article J Oncol Pract · April 2017 INTRODUCTION: Breast cancer treatment costs are rising, and identification of high-value oncology treatment strategies is increasingly needed. We sought to determine the potential cost savings associated with an evidence-based radiation treatment (RT) appr ... Full text Link to item Cite

Clinical Utility of the 12-Gene DCIS Score Assay: Impact on Radiotherapy Recommendations for Patients with Ductal Carcinoma In Situ.

Journal Article Ann Surg Oncol · March 2017 OBJECTIVE: The aim of this study was to determine the impact of the results of the 12-gene DCIS Score assay on (i) radiotherapy recommendations for patients with pure ductal carcinoma in situ (DCIS) following breast-conserving surgery (BCS), and (ii) patie ... Full text Link to item Cite

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.

Journal Article Cell · February 23, 2017 Investigating therapeutic "outliers" that show exceptional responses to anti-cancer treatment can uncover biomarkers of drug sensitivity. We performed preclinical trials investigating primary murine acute myeloid leukemias (AMLs) generated by retroviral in ... Full text Link to item Cite

Abstract P1-06-06: Evidence for tumor heterogeneity and clonal evolution during invasive progression of breast cancer

Conference Cancer Research · February 15, 2017 AbstractPurpose: Intratumoral heterogeneity is well recognized to be an important driver of treatment resistance and metastasis. We undertook this N of one study to measure the degree of heterogeneity in a s ... Full text Cite

H3K27me3 Expression and X Chromosome Inactivation in Breast Carcinoma

Conference LABORATORY INVESTIGATION · February 1, 2017 Link to item Cite

Postmastectomy Radiotherapy: An American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Focused Guideline Update.

Journal Article Ann Surg Oncol · January 2017 PURPOSE: A joint American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology panel convened to develop a focused update of the American Society of Clinical Oncology guideline concerning use of postmastec ... Full text Link to item Cite

Prediction of occult invasive disease in ductal carcinoma in situ using computer-extracted mammographic features

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2017 Predicting the risk of occult invasive disease in ductal carcinoma in situ (DCIS) is an important task to help address the overdiagnosis and overtreatment problems associated with breast cancer. In this work, we investigated the feasibility of using comput ... Full text Cite

Can upstaging of ductal carcinoma in situ be predicted at biopsy by histologic and mammographic features?

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2017 Reducing the overdiagnosis and overtreatment associated with ductal carcinoma in situ (DCIS) requires accurate prediction of the invasive potential at cancer screening. In this work, we investigated the utility of pre-operative histologic and mammographic ... Full text Cite

Postmastectomy Radiotherapy: An American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Focused Guideline Update.

Journal Article J Clin Oncol · December 20, 2016 Purpose A joint American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology panel convened to develop a focused update of the American Society of Clinical Oncology guideline concerning use of postmastect ... Full text Link to item Cite

Reply to J. Heil et al.

Journal Article J Clin Oncol · December 2016 Full text Link to item Cite

Comparing Coordinated Versus Sequential Salpingo-Oophorectomy for BRCA1 and BRCA2 Mutation Carriers With Breast Cancer.

Journal Article Clin Breast Cancer · December 2016 BACKGROUND: Women with breast cancer who carry BRCA1 or BRCA2 mutations must also consider risk-reducing salpingo-oophorectomy (RRSO) and how to coordinate this procedure with their breast surgery. We report the factors associated with coordinated versus s ... Full text Link to item Cite

DCIS-Conservative Nonsurgical Management- The Problem of Over-diagnosis: What is the Path Forward?

Conference MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY · December 1, 2016 Link to item Cite

Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma In Situ.

Journal Article J Clin Oncol · November 20, 2016 Background Controversy exists regarding the optimal negative margin width for ductal carcinoma in situ (DCIS) treated with breast-conserving surgery and whole-breast irradiation (WBRT). Methods A multidisciplinary consensus panel used a meta-analysis of ma ... Full text Link to item Cite

Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery with Whole-Breast Irradiation in Ductal Carcinoma In Situ.

Journal Article Ann Surg Oncol · November 2016 PURPOSE: Controversy exists regarding the optimal negative margin width for ductal carcinoma in situ (DCIS) treated with breast-conserving surgery and whole-breast irradiation. METHODS: A multidisciplinary consensus panel used a meta-analysis of margin wid ... Full text Link to item Cite

The Impact of the Affordable Care Act on North Carolinian Breast Cancer Patients Seeking Financial Support for Treatment.

Journal Article Ann Surg Oncol · October 2016 BACKGROUND: The Affordable Care Act (ACA) was instated on 23 March 2010 to improve healthcare quality, reduce costs, and increase access. The Pretty in Pink Foundation (PIPF), a non-profit 501(C)(3) organization in North Carolina, provides financial assist ... Full text Link to item Cite

Current Trends in the Management of Ductal Carcinoma In Situ.

Journal Article Oncology (Williston Park) · September 15, 2016 Ductal carcinoma in situ (DCIS), once a rare entity, now comprises up to 30% of newly diagnosed breast cancers detected on mammography. It is now appreciated as a widely heterogeneous disease, with indolent lesions of minimal clinical significance on one e ... Link to item Cite

Current Trends in the Management of Ductal Carcinoma In Situ

Journal Article Oncology (Williston Park, N.Y.) · September 15, 2016 Ductal carcinoma in situ (DCIS), once a rare entity, now comprises up to 30% of newly diagnosed breast cancers detected on mammography. It is now appreciated as a widely heterogeneous disease, with indolent lesions of minimal clinical significance on one e ... Cite

Current Trends in the Management of Ductal Carcinoma In Situ

Journal Article Oncology (Williston Park, N.Y.) · September 15, 2016 Ductal carcinoma in situ (DCIS), once a rare entity, now comprises up to 30% of newly diagnosed breast cancers detected on mammography. It is now appreciated as a widely heterogeneous disease, with indolent lesions of minimal clinical significance on one e ... Cite

Can Vascular Patterns on Preoperative Magnetic Resonance Imaging Help Predict Skin Necrosis after Nipple-Sparing Mastectomy?

Journal Article J Am Coll Surg · August 2016 BACKGROUND: Nipple-areola complex (NAC) and skin flap ischemia and necrosis can occur after nipple-sparing mastectomy (NSM). The purpose of this study was to correlate vascular findings on MRI with outcomes in patients who underwent NSM. STUDY DESIGN: Fema ... Full text Link to item Cite

Prognostic Impact of 21-Gene Recurrence Score in Patients With Stage IV Breast Cancer: TBCRC 013.

Journal Article J Clin Oncol · July 10, 2016 PURPOSE: The objective of this study was to determine whether the 21-gene Recurrence Score (RS) provides clinically meaningful information in patients with de novo stage IV breast cancer enrolled in the Translational Breast Cancer Research Consortium (TBCR ... Full text Link to item Cite

Contemporary management of ductal carcinoma in situ and lobular carcinoma in situ.

Journal Article Chin Clin Oncol · June 2016 The management of in situ lesions ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS) continues to evolve. These diagnoses now comprise a large burden of mammographically diagnosed cancers, and with a global trend towards more population-b ... Full text Link to item Cite

Patient-Reported Outcomes After Choice for Contralateral Prophylactic Mastectomy.

Conference J Clin Oncol · May 1, 2016 PURPOSE: The rate of contralateral prophylactic mastectomies (CPMs) continues to rise, although there is little evidence to support improvement in quality of life (QOL) with CPM. We sought to ascertain whether patient-reported outcomes and, more specifical ... Full text Link to item Cite

Outcomes of Active Surveillance for Ductal Carcinoma in Situ: A Computational Risk Analysis.

Journal Article J Natl Cancer Inst · May 2016 BACKGROUND: Ductal carcinoma in situ (DCIS) is a noninvasive breast lesion with uncertain risk for invasive progression. Usual care (UC) for DCIS consists of treatment upon diagnosis, thus potentially overtreating patients with low propensity for progressi ... Full text Link to item Cite

Imaging-Guided Core-Needle Breast Biopsy: Impact of Meditation and Music Interventions on Patient Anxiety, Pain, and Fatigue.

Journal Article J Am Coll Radiol · May 2016 PURPOSE: To evaluate the impact of guided meditation and music interventions on patient anxiety, pain, and fatigue during imaging-guided breast biopsy. METHODS: After giving informed consent, 121 women needing percutaneous imaging-guided breast biopsy were ... Full text Link to item Cite

Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In-situ in Patients with Lobular Neoplasia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 020).

Journal Article Ann Surg Oncol · March 2016 BACKGROUND: Lobular neoplasia (LN) represents a spectrum of atypical proliferative lesions, including atypical lobular hyperplasia and lobular carcinoma-in-situ. The need for excision for LN found on core biopsy (CB) is controversial. We conducted a prospe ... Full text Link to item Cite

Abstract P5-17-03: The 12-gene DCIS score assay: Impact on radiation treatment (XRT) recommendations and clinical utility

Conference Cancer Research · February 15, 2016 AbstractBackground: In the management of DCIS clinicians and patients (pts) must choose between the various options for breast conservation treatment based on an assessment of local recurrence (LR) risk. Tra ... Full text Cite

Abstract ES8-3: Endocrine management of premalignant lesions and DCIS

Conference Cancer Research · February 15, 2016 AbstractIt has been recognized for many years that there exist pathological entities associated with an increased risk of invasive breast cancer. The most frequently encountered are atypical hyperplasia (AH) ... Full text Cite

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.

Journal Article Sci Transl Med · January 6, 2016 Local recurrence is a common cause of treatment failure for patients with solid tumors. Intraoperative detection of microscopic residual cancer in the tumor bed could be used to decrease the risk of a positive surgical margin, reduce rates of reexcision, a ... Full text Link to item Cite

Postmastectomy Radiotherapy: An American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Focused Guideline Update.

Journal Article Pract Radiat Oncol · 2016 UNLABELLED: A joint American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology panel convened to develop a focused update of the American Society of Clinical Oncology guideline concerning use of postmas ... Full text Link to item Cite

Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma in Situ.

Journal Article Pract Radiat Oncol · 2016 PURPOSE: Controversy exists regarding the optimal negative margin width for ductal carcinoma in situ (DCIS) treated with breast-conserving surgery and whole-breast irradiation. METHODS AND MATERIALS: A multidisciplinary consensus panel used a meta-analysis ... Full text Link to item Cite

DNA defects, epigenetics, and gene expression in cancer-adjacent breast: a study from The Cancer Genome Atlas.

Journal Article NPJ Breast Cancer · 2016 Recurrence rates after breast-conserving therapy may depend on genomic characteristics of cancer-adjacent, benign-appearing tissue. Studies have not evaluated recurrence in association with multiple genomic characteristics of cancer-adjacent breast tissue. ... Full text Link to item Cite

Trends in Treatment Patterns and Outcomes for Ductal Carcinoma In Situ.

Journal Article J Natl Cancer Inst · December 2015 BACKGROUND: Impact of contemporary treatment of pre-invasive breast cancer (ductal carcinoma in situ [DCIS]) on long-term outcomes remains poorly defined. We aimed to evaluate national treatment trends for DCIS and to determine their impact on disease-spec ... Full text Link to item Cite

Preoperative Partial Breast Radiation Therapy: Short-term Imaging Outcomes With Two Unique Treatment Regimens

Conference International Journal of Radiation Oncology*Biology*Physics · November 2015 Full text Cite

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.

Journal Article Cell · October 8, 2015 Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best kn ... Full text Link to item Cite

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration.

Journal Article Integr Biol (Camb) · October 2015 Tumors are stiff and data suggest that the extracellular matrix stiffening that correlates with experimental mammary malignancy drives tumor invasion and metastasis. Nevertheless, the relationship between tissue and extracellular matrix stiffness and human ... Full text Link to item Cite

Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2015 PURPOSE: Women with biologically favorable early-stage breast cancer are increasingly treated with accelerated partial breast radiation (PBI). However, treatment-related morbidities have been linked to the large postoperative treatment volumes required for ... Full text Link to item Cite

Lobular breast cancer series: imaging.

Journal Article Breast Cancer Res · July 11, 2015 The limitations of mammography in the detection and evaluation of invasive lobular carcinoma (ILC) have long been recognized, presenting real clinical challenges in treatment planning for these tumors. However, advances in mammography, ultrasound, and magn ... Full text Link to item Cite

Impact of delayed lymphoscintigraphy for sentinel lymphnode biopsy for breast cancer.

Journal Article J Surg Oncol · June 2015 BACKGROUND: Despite universal adoption of sentinel lymph node biopsy (SLNB) for breast cancer, there remains no standardized protocol for preoperative lymphoscintographic assessment of sentinel nodes. Both immediate and delayed lymphoscintigraphy are curre ... Full text Link to item Cite

Abstract P1-10-02: Adjuvant radiation after lumpectomy: A cost comparison of treatment patterns in 43,247 women from the National Cancer Data Base

Conference Cancer Research · May 1, 2015 AbstractBACKGROUND: Breast cancer treatment contributes the greatest proportion of cancer-related health care spending in the United States. Locoregional therapy comprises a significant share of these costs. ... Full text Cite

Abstract P3-07-22: Predictors of neoadjuvant chemotherapy use in women with breast cancer: A review of 169,329 patients from the American College of Surgeons' National Cancer Database

Conference Cancer Research · May 1, 2015 AbstractBackground: Randomized controlled trials have demonstrated that neoadjuvant chemotherapy (NAC) offers equivalent long-term outcomes when compared to adjuvant chemotherapy while improving rates of bre ... Full text Cite

Practice patterns in the delivery of radiation therapy after mastectomy among the University of California Athena Breast Health Network.

Journal Article Clin Breast Cancer · February 2015 BACKGROUND: Practice patterns vary with the planning and delivery of PMRT. In our investigation we examined practice patterns in the use of chest wall bolus and a boost among the Athena Breast Health Network (Athena). MATERIALS AND METHODS: Athena is a col ... Full text Link to item Cite

Monitoring and surveillance following DCIS treatment

Journal Article · January 1, 2015 Currently, more than 20% of breast cancers diagnosed in the USA are ductal carcinoma in situ (DCIS; Brinton et al., J Natl Cancer Inst 100:1643-1648, 2008; DeSantis et al., CA Cancer J Clin 64:52-62, 2014; Ernster et al., J Natl Cancer Inst 94:1546-1554, 2 ... Full text Cite

Preclinical efficacy of MEK inhibition in Nras-mutant AML.

Journal Article Blood · December 18, 2014 Oncogenic NRAS mutations are highly prevalent in acute myeloid leukemia (AML). Genetic analysis supports the hypothesis that NRAS mutations cooperate with antecedent molecular lesions in leukemogenesis, but have limited independent prognostic significance. ... Full text Link to item Cite

Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells.

Journal Article Cancer Cell · November 10, 2014 Blockade of colony-stimulating factor-1 (CSF-1) limits macrophage infiltration and improves response of mammary carcinomas to chemotherapy. Herein we identify interleukin (IL)-10 expression by macrophages as the critical mediator of this phenotype. Infiltr ... Full text Link to item Cite

Should ductal carcinoma in situ be treated?

Other Oncology Report · November 1, 2014 Cite

Breast conservation: is the survival better for mastectomy?

Journal Article J Surg Oncol · July 2014 Breast conserving therapy with radiation is now firmly established as an effective treatment option for early stage disease, and has been thought for decades to yield equivalent survival outcomes to mastectomy. However, recently published observational stu ... Full text Link to item Cite

Patient-reported outcomes and satisfaction after total skin-sparing mastectomy and immediate expander-implant reconstruction.

Journal Article Ann Plast Surg · May 2014 BACKGROUND: Total skin-sparing mastectomy (TSSM) with preservation of the nipple-areolar complex skin has become more widely accepted. Few studies looking at outcomes after TSSM and immediate reconstruction have focused on patient-reported outcomes and tre ... Full text Link to item Cite

Addressing overdiagnosis and overtreatment in cancer: a prescription for change.

Journal Article Lancet Oncol · May 2014 A vast range of disorders--from indolent to fast-growing lesions--are labelled as cancer. Therefore, we believe that several changes should be made to the approach to cancer screening and care, such as use of new terminology for indolent and precancerous d ... Full text Link to item Cite

The current clinical value of the DCIS Score.

Conference Oncology (Williston Park) · May 2014 The management of ductal carcinoma in situ (DCIS) can be controversial. Widespread adoption of mammographic screening has made DCIS a more frequent diagnosis, and increasingly smaller, lower-grade lesions are being detected. DCIS is commonly treated with b ... Link to item Cite

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.

Journal Article Nat Med · April 2014 Tissue mechanics regulate development and homeostasis and are consistently modified in tumor progression. Nevertheless, the fundamental molecular mechanisms through which altered mechanics regulate tissue behavior and the clinical relevance of these change ... Full text Link to item Cite

Incidence Patterns of Breast Cancer among Women 35 and Younger at Diagnosis

Conference ANNALS OF SURGICAL ONCOLOGY · February 1, 2014 Link to item Cite

Risk of positive nonsentinel nodes in women with 1-2 positive sentinel nodes related to age and molecular subtype approximated by receptor status.

Journal Article Breast J · 2014 We examine risk of positive nonsentinel axillary nodes (NSN) and ≥4 positive nodes in patients with 1-2 positive sentinel nodes (SN) by age and tumor subtype approximated by ER, PR, and Her2 receptor status. Review of two institutional databases demonstrat ... Full text Link to item Cite

New therapeutic approaches for invasive lobular carcinoma

Journal Article Current Breast Cancer Reports · January 1, 2014 Invasive lobular carcinoma (ILC) is the second most common histological subtype among newly diagnosed breast cancers. The clinical features of ILC are related to the underlying biology of this disease, which is distinguished by loss of the cell adhesion pr ... Full text Cite

Abstract P5-14-04: Preoperative single-fraction partial breast radiotherapy – Initial results from a novel phase I dose-escalation protocol with exploration of radiation response biomarkers

Conference Cancer Research · December 15, 2013 AbstractPurpose/Objectives(s): Women with biologically favorable early stage breast cancer are increasingly treated with accelerated partial breast techniques. However, many alternative techniques require co ... Full text Cite

Ductal carcinoma in situ: knowledge of associated risks and prognosis among Latina and non-Latina white women.

Journal Article Breast Cancer Res Treat · September 2013 While not itself life-threatening, ductal carcinoma in situ (DCIS) can progress to invasive disease if untreated, and confers an increased risk of future breast cancer. We investigated knowledge of DCIS among a cohort of English- and Spanish-speaking Latin ... Full text Link to item Cite

Ductal carcinoma in situ (DCIS): posttreatment follow-up care among Latina and non-Latina White women.

Journal Article J Cancer Surviv · June 2013 BACKGROUND: There is a lack of information about posttreatment care among patients with ductal carcinoma in situ (DCIS). This study compares posttreatment care by ethnicity-language and physician specialty among Latina and White women with DCIS. METHODS: L ... Full text Link to item Cite

New treatment paradigms for patients with ductal carcinoma in situ

Journal Article Current Breast Cancer Reports · June 1, 2013 One of the most poorly understood clinical diagnoses in breast cancer is ductal carcinoma in situ (DCIS), which now accounts for almost one third of all mammographically detected malignancies. Detection and diagnosis of DCIS have improved, and mature data ... Full text Cite

FOXP3-positive regulatory T lymphocytes and epithelial FOXP3 expression in synchronous normal, ductal carcinoma in situ, and invasive cancer of the breast.

Journal Article Breast Cancer Res Treat · June 2013 FOXP3-expressing T regulatory lymphocytes (Tregs) have been described as putative mediators of immune tolerance, and thus facilitators of tumor growth. When found in association with various malignancies, Tregs are generally markers of poor clinical outcom ... Full text Link to item Cite

Survival after lumpectomy and mastectomy for early stage invasive breast cancer: the effect of age and hormone receptor status.

Journal Article Cancer · April 1, 2013 BACKGROUND: Randomized clinical trials (RCT) have demonstrated equivalent survival for breast-conserving therapy with radiation (BCT) and mastectomy for early-stage breast cancer. A large, population-based series of women who underwent BCT or mastectomy wa ... Full text Link to item Cite

Multidisciplinary care of patients with early-stage breast cancer.

Journal Article Surg Oncol Clin N Am · April 2013 There is a compelling need for close coordination and integration of multiple specialties in the management of patients with early-stage breast cancer. Optimal patient care and outcomes depend on the sequential and often simultaneous participation and dial ... Full text Link to item Cite

Features of occult invasion in biopsy-proven DCIS at breast MRI.

Journal Article Breast J · 2013 The purpose of this study is to determine if MRI BI-RADS criteria or radiologist perception correlate with presence of invasive cancer after initial core biopsy of ductal carcinoma in situ (DCIS). Retrospective search spanning 2000-2007 identified all core ... Full text Link to item Cite

Abstract P4-14-04: Total skin-sparing mastectomy in BRCA mutation carriers

Journal Article Cancer Research · December 15, 2012 AbstractBACKGROUND: Total skin-sparing mastectomy (TSSM) with preservation of the nipple-areolar complex skin has become increasingly accepted as an oncologically safe procedure for both prophylactic and the ... Full text Cite

Abstract P4-16-07: Selective use of post-mastectomy radiation therapy in the neoadjuvant setting

Journal Article Cancer Research · December 15, 2012 AbstractBackground: Neoadjuvant chemotherapy, once reserved for locally advanced breast cancer, has become more common in Stage II disease. While one of its proven benefits is an increase in the frequency of ... Full text Cite

Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes.

Journal Article Breast Cancer Res · December 7, 2012 INTRODUCTION: Tumors are characterized by alterations in the epithelial and stromal compartments, which both contribute to tumor promotion. However, where, when, and how the tumor stroma develops is still poorly understood. We previously demonstrated that ... Full text Link to item Cite

Paget's disease of the breast masquerading as squamous cell carcinoma on cytology: a case report.

Journal Article Diagn Cytopathol · November 2012 Paget's disease is an uncommon manifestation of breast carcinoma occurring in 1-2% of female patients with breast cancer. Here, we present a case of Paget's disease of the breast, which was initially interpreted as squamous cell carcinoma on cytology. This ... Full text Link to item Cite

Lobular histology and response to neoadjuvant chemotherapy in invasive breast cancer.

Journal Article Breast Cancer Res Treat · November 2012 Invasive lobular carcinoma (ILC) has been reported to be less responsive to neoadjuvant chemotherapy (NAC) than invasive ductal carcinoma (IDC). We sought to determine whether ILC histology indeed predicts poor response to NAC by analyzing tumor characteri ... Full text Link to item Cite

Outcomes after total skin-sparing mastectomy and immediate reconstruction in 657 breasts.

Journal Article Ann Surg Oncol · October 2012 BACKGROUND: Total skin-sparing mastectomy (TSSM), a technique comprising removal of all breast and nipple tissue while preserving the entire skin envelope, is increasingly offered to women for therapeutic and prophylactic indications. However, standard use ... Full text Link to item Cite

Increasing the time to expander-implant exchange after postmastectomy radiation therapy reduces expander-implant failure.

Journal Article Plast Reconstr Surg · September 2012 BACKGROUND: Increased rates of complications can occur when postmastectomy radiation therapy is required after immediate expander-implant breast reconstruction. The sequence and timing of tissue expansion and implant exchange with regard to postmastectomy ... Full text Link to item Cite

Evaluating the feasibility of extended partial mastectomy and immediate reduction mammoplasty reconstruction as an alternative to mastectomy.

Journal Article Ann Surg · June 2012 OBJECTIVES: To assess the efficacy of using concurrent partial mastectomy and reduction mammoplasty for resection of a wide range of tumor sizes and compare oncologic outcomes and postoperative complications on the basis of tumor size. BACKGROUND: Although ... Full text Link to item Cite

The effects of acellular dermal matrix in expander-implant breast reconstruction after total skin-sparing mastectomy: results of a prospective practice improvement study.

Journal Article Plast Reconstr Surg · June 2012 BACKGROUND: Neither outcome after total skin-sparing mastectomy and expander-implant reconstruction using acellular dermal matrix nor a strategy for optimal acellular dermal matrix selection criteria has been well described. METHODS: Prospective review of ... Full text Link to item Cite

Role of postmastectomy radiation after neoadjuvant chemotherapy in stage II-III breast cancer.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2012 PURPOSE: To identify a cohort of women treated with neoadjuvant chemotherapy and mastectomy for whom postmastectomy radiation therapy (PMRT) may be omitted according to the projected risk of local-regional failure (LRF). METHODS AND MATERIALS: Seven breast ... Full text Link to item Cite

Long-term reconstructive outcomes after expander-implant breast reconstruction with serious infectious or wound-healing complications.

Journal Article Ann Plast Surg · April 2012 INTRODUCTION: Immediate expander-implant breast reconstruction has been associated with postoperative complications, including infection and wound-healing problems. In extreme cases, these issues can lead to expander-implant loss. Little is known about the ... Full text Link to item Cite

Leukocyte composition of human breast cancer.

Journal Article Proc Natl Acad Sci U S A · February 21, 2012 Retrospective clinical studies have used immune-based biomarkers, alone or in combination, to predict survival outcomes for women with breast cancer (BC); however, the limitations inherent to immunohistochemical analyses prevent comprehensive descriptions ... Full text Link to item Cite

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras.

Journal Article Blood · January 26, 2012 The palmitoylation/depalmitoylation cycle of posttranslational processing is a potential therapeutic target for selectively inhibiting the growth of hematologic cancers with somatic NRAS mutations. To investigate this question at the single-cell level, we ... Full text Link to item Cite

Adjuvant hormonal therapy use among women with ductal carcinoma in situ.

Journal Article J Womens Health (Larchmt) · January 2012 OBJECTIVE: In the absence of consistent guidelines for the use of adjuvant hormonal therapy (HT) in treating ductal carcinoma in situ (DCIS), our purpose was to explore a variety of factors associated with discussion, use, and discontinuation of this thera ... Full text Link to item Cite

Neoadjuvant endocrine therapy in the treatment of early-stage breast cancer

Chapter · December 1, 2011 Endocrine therapy is the first targeted biologic therapy to be used in breast cancer treatment and was initially conceived in 1895. Based on the observation that lactation led to a cancer-like ductal epithelial proliferation in cattle and that castration o ... Full text Cite

Outcome of long term active surveillance for estrogen receptor-positive ductal carcinoma in situ.

Journal Article Breast · December 2011 INTRODUCTION: An option for active surveillance is not currently offered to patients with ductal carcinoma in situ (DCIS); however a small number of women decline standard surgical treatment for noninvasive cancer. The purpose of this study was to assess o ... Full text Link to item Cite

Genomic alterations and phenotype of large compared to small high-grade ductal carcinoma in situ.

Journal Article Hum Pathol · October 2011 A clinically distinct subgroup of pure ductal carcinoma in situ presents as an extensive, high-grade lesion, which nevertheless lacks invasion. We sought to evaluate differences between those ductal carcinomas in situ presenting as large versus small lesio ... Full text Link to item Cite

The effect of system-level access factors on receipt of reconstruction among Latina and white women with DCIS.

Journal Article Breast Cancer Res Treat · October 2011 Treatment decisions associated with ductal carcinoma in situ (DCIS), including the decision to undergo breast reconstruction, may be more problematic for Latinas due to access and language issues. To help understand the factors that influence patients' rec ... Full text Link to item Cite

Characterizing the impact of 25 years of DCIS treatment.

Journal Article Breast Cancer Res Treat · August 2011 The significant increase in the detection and treatment of ductal carcinoma in situ (DCIS) since the introduction of screening mammography has not been accompanied by the anticipated reduction in invasive breast cancer (IBC) incidence. The prevalence of DC ... Full text Link to item Cite

Language barriers and patient-centered breast cancer care.

Journal Article Patient Educ Couns · August 2011 OBJECTIVE: Provision of high quality patient-centered care is fundamental to eliminating healthcare disparities in breast cancer. We investigated physicians' experiences communicating with limited English proficient (LEP) breast cancer patients. METHODS: S ... Full text Link to item Cite

Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.

Journal Article Cancer Discov · June 2011 UNLABELLED: Immune-regulated pathways influence multiple aspects of cancer development. In this article we demonstrate that both macrophage abundance and T-cell abundance in breast cancer represent prognostic indicators for recurrence-free and overall surv ... Full text Link to item Cite

Is radiation indicated in patients with ductal carcinoma in situ and close or positive mastectomy margins?

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2011 PURPOSE: Resection margin status is one of the most significant factors for local recurrence in patients with ductal carcinoma in situ (DCIS) treated with breast-conserving surgery with or without radiation. However, its impact on chest wall recurrence in ... Full text Link to item Cite

The impact of lobular histology on breast cancer treatment.

Journal Article Oncology (Williston Park) · April 15, 2011 Lobular neoplasias are a distinct clinical entity with subtle differences in locoregional treatment considerations when compared with ductal cancers. Although overall surgical recommendations do not differ significantly between breast cancers of lobular ve ... Link to item Cite

The impact of preoperative magnetic resonance imaging on surgical treatment and outcomes for ductal carcinoma in situ

Journal Article Clinical Breast Cancer · March 1, 2011 Background: Although magnetic resonance imaging (MRI) is a useful imaging modality for invasive cancer, its role in preoperative surgical planning for ductal carcinoma in situ (DCIS) has not been established. We sought to determine whether preoperative MRI ... Full text Cite

Selection of treatment among Latina and non-Latina white women with ductal carcinoma in situ.

Journal Article J Womens Health (Larchmt) · February 2011 BACKGROUND: The growing rates of ductal carcinoma in situ (DCIS) and evidence that Latinas may underuse breast-conserving surgery (BCS) compared with white women highlight the need to better understand how treatment decisions are made in this understudied ... Full text Link to item Cite

Intraoperative frozen section analysis of sentinel lymph nodes in breast cancer patients: a meta-analysis and single-institution experience.

Journal Article Cancer · January 15, 2011 BACKGROUND: Accurate intraoperative pathologic examination of sentinel lymph nodes (SLNs) has been an important tool that can reduce the need for reoperations in patients with SLN-positive breast cancer. The objective of the current study was to determine ... Full text Link to item Cite

Spontaneous resolution of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis.

Journal Article Pediatr Blood Cancer · October 2010 Secondary hemophagocytic lymphohistiocytosis (sHLH) is a reactive, proliferative disorder of the immune system resulting in lymphohistiocytic proliferation, hemophagocytosis, and cytokine dysregulation. The most common infectious trigger in sHLH is Epstein ... Full text Link to item Cite

Impact of chemotherapy on postoperative complications after mastectomy and immediate breast reconstruction.

Journal Article Arch Surg · September 2010 OBJECTIVES: To determine the impact of chemotherapy and the timing of chemotherapy on postoperative outcomes after mastectomy and immediate breast reconstruction. DESIGN: Retrospective review. SETTING: University tertiary care institution. PATIENTS: One hu ... Full text Link to item Cite

Status of intraductal therapy for ductal carcinoma in Situ

Journal Article Current Breast Cancer Reports · June 1, 2010 The intraductal approach is particularly appealing in the setting of ductal carcinoma in situ (DCIS), a preinvasive breast neoplasm that is thought to be entirely intraductal in its extent. Based on an emerging understanding of the anatomy of the ductal sy ... Full text Cite

The impact of surgery on ductal carcinoma in situ outcomes: the use of mastectomy.

Journal Article J Natl Cancer Inst Monogr · 2010 Mastectomy has been the historical mainstay of treatment for ductal carcinoma in situ (DCIS), but over time, there have been significant changes in its use for preinvasive breast cancer. Although there was an early reduction in mastectomy rates for DCIS wi ... Full text Link to item Cite

Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer.

Journal Article Breast Cancer Res Treat · January 2010 The purpose of this study is to determine the biologic impact of short-term lipophilic statin exposure on in situ and invasive breast cancer through paired tissue, blood and imaging-based biomarkers. A perioperative window trial of fluvastatin was conducte ... Full text Link to item Cite

Genetic and phenotypic characteristics of pleomorphic lobular carcinoma in situ of the breast.

Journal Article Am J Surg Pathol · November 2009 The clinical, pathologic, and molecular features of pleomorphic lobular carcinoma in situ (PLCIS) and the relationship of PLCIS to classic LCIS (CLCIS) are poorly defined. In this study, we analyzed 31 cases of PLCIS (13 apocrine and 18 nonapocrine subtype ... Full text Link to item Cite

Bacteriologic features of surgical site infections following breast surgery.

Journal Article Am J Surg · October 2009 BACKGROUND: Perioperative antibiotic prophylaxis to prevent surgical site infections (SSIs) after breast surgery is common practice. Breast SSIs were investigated to determine bacterial isolates, resistance patterns, and the appropriateness of cefazolin, t ... Full text Link to item Cite

Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situ.

Journal Article BMC Cancer · August 18, 2009 BACKGROUND: Endocrine therapy is commonly recommended in the adjuvant setting for patients as treatment for ductal carcinoma in situ (DCIS). However, it is unknown whether a neoadjuvant (preoperative) anti-estrogen approach to DCIS results in any biologica ... Full text Link to item Cite

Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression.

Journal Article Clin Cancer Res · May 1, 2009 PURPOSE: Excess histone deacetylase (HDAC) activity can induce hypoacetylation of histone and nonhistone protein substrates, altering gene expression patterns and cell behavior potentially associated with malignant transformation. However, HDAC expression ... Full text Link to item Cite

Total skin-sparing mastectomy: complications and local recurrence rates in 2 cohorts of patients.

Journal Article Ann Surg · January 2009 PURPOSE: Dissemination of the total skin-sparing mastectomy (TSSM) technique is limited by concerns of nipple viability, flap necrosis, local recurrence risk, and the technical challenge of this procedure. We sought to define the impact of surgical and rec ... Full text Link to item Cite

Prognostic implications of positive nonsentinel lymph nodes removed during selective sentinel lymphadenectomy for breast cancer.

Journal Article Breast J · 2009 Nonsentinel lymph nodes (SLNs) are commonly removed at the time of selective sentinel lymphadenectomy (SSL). Their predictive value for the rest of the nodal basin is unknown. A retrospective review of 436 breast cancer patients who underwent SSL between 1 ... Full text Link to item Cite

Is it necessary to harvest additional lymph nodes after resection of the most radioactive sentinel lymph node in breast cancer?

Journal Article J Am Coll Surg · December 2008 BACKGROUND: No consensus exists about the number of sentinel lymph nodes (SLNs) that should be removed based on radioactivity counts in breast cancer, although the "10% rule" is often used. We hypothesized that the node with the highest radioactivity would ... Full text Link to item Cite

Association between breast density and subsequent breast cancer following treatment for ductal carcinoma in situ.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2007 BACKGROUND: Risk of invasive cancer following treatment for ductal carcinoma in situ (DCIS) is associated with both treatment- and tumor-related factors. However, it is unknown whether stromal factors such as breast density may also influence subsequent in ... Full text Link to item Cite

Response [5]

Other Breast Journal · September 1, 2007 Full text Cite

Identification of a robust gene signature that predicts breast cancer outcome in independent data sets.

Journal Article BMC Cancer · April 11, 2007 BACKGROUND: Breast cancer is a heterogeneous disease, presenting with a wide range of histologic, clinical, and genetic features. Microarray technology has shown promise in predicting outcome in these patients. METHODS: We profiled 162 breast tumors using ... Full text Link to item Cite

Ductal carcinoma in situ in BRCA mutation carriers.

Journal Article J Clin Oncol · February 20, 2007 PURPOSE: The current literature suggests that ductal carcinoma in situ (DCIS) of the breast is infrequently diagnosed in patients with BRCA germline mutations. We studied women at high risk of hereditary breast cancer syndromes who underwent testing for BR ... Full text Link to item Cite

Type and duration of exogenous hormone use affects breast cancer histology.

Journal Article Ann Surg Oncol · February 2007 BACKGROUND: It is unclear whether hormone replacement therapy (HRT), in addition to increasing risk for breast cancer, affects the type of breast cancer diagnosed. We conducted this investigation to assess whether the type of hormone used (none, estrogen, ... Full text Link to item Cite

Information exchange and decision making in the treatment of Latina and white women with ductal carcinoma in situ.

Journal Article J Psychosoc Oncol · 2007 The natural history of ductal carcinoma in situ (DCIS) is largely unknown, and its optimal treatment remains controversial. Using semi-structured interviews, this study compared 18 White and 16 Latina women's understanding of their DCIS diagnosis, treatmen ... Full text Link to item Cite

Magnetic resonance imaging captures the biology of ductal carcinoma in situ.

Journal Article J Clin Oncol · October 1, 2006 PURPOSE: Magnetic resonance imaging (MRI) is an important tool for characterizing invasive breast cancer but has proven to be more challenging in the setting of ductal carcinoma in situ (DCIS). We investigated whether MRI features of DCIS reflect differenc ... Full text Link to item Cite

The effect of sentinel node tumor burden on non-sentinel node status and recurrence rates in breast cancer.

Journal Article Ann Surg Oncol · September 2005 BACKGROUND: Routine axillary lymph node dissection (ALND) after selective sentinel lymphadenectomy (SSL) in the treatment of breast cancer remains controversial. We sought to determine the need for routine ALND by exploring the relationship between sentine ... Full text Link to item Cite

Innovations in breast cancer care

Chapter · June 1, 2005 PURPOSE: To examine the treatment of breast cancer from a historic perspective and explore current therapies and innovations in diagnosis and treatment. EPIDEMIOLOGY: In 2003, 212 600 new cases of breast cancer were diagnosed, and it is estimated that more ... Cite

MRI measurements of breast tumor volume predict response to neoadjuvant chemotherapy and recurrence-free survival.

Journal Article AJR Am J Roentgenol · June 2005 OBJECTIVE: The purpose of this study was to assess the value of MRI measurements of breast tumor size for predicting recurrence-free survival (RFS) in patients undergoing neoadjuvant (preoperative) chemotherapy and to compare the predictive value of MRI wi ... Full text Link to item Cite

Clinical application of array-based comparative genomic hybridization to define the relationship between multiple synchronous tumors.

Journal Article Mod Pathol · April 2005 Array-based comparative genomic hybridization (CGH) is a technique that allows genome wide screening of gains and losses in DNA copy number. In cases where multiple tumors are encountered, this genetic technique may prove useful in differentiating new prim ... Full text Link to item Cite

Development of a novel method for measuring in vivo breast epithelial cell proliferation in humans.

Journal Article Breast Cancer Res Treat · February 2005 Cell proliferation plays an important role in all stages of carcinogenesis. Currently, no safe, direct, in vivo method of measuring breast epithelial cell (BEC) proliferation rates in humans exists. Static immunohistochemical markers of cell proliferation, ... Full text Link to item Cite

Array-based comparative genomic hybridization from formalin-fixed, paraffin-embedded breast tumors.

Journal Article J Mol Diagn · February 2005 Identification of prognostic and predictive genomic markers requires long-term clinical follow-up of patients. Extraction of high-quality DNA from archived formalin-fixed, paraffin-embedded material is essential for such studies. Of particular importance i ... Full text Link to item Cite

Safety of immediate transverse rectus abdominis myocutaneous breast reconstruction for patients with locally advanced disease.

Journal Article Arch Surg · February 2005 HYPOTHESIS: Immediate transverse rectus abdominis myocutaneous breast reconstruction combined with postoperative radiation therapy after mastectomy is safe and effective. DESIGN: Retrospective case series. SETTING: University-based teaching hospital. PATIE ... Full text Link to item Cite

Primary tumor characteristics predict sentinel lymph node macrometastasis in breast cancer.

Journal Article Breast J · 2005 Selective sentinel lymphadenectomy (SSL) is rapidly becoming the standard of care in the surgical management of patients with early breast cancer. Sentinel lymph node macrometastasis has been well documented in the literature to have a higher risk of nonse ... Full text Link to item Cite

Ratio of positive to total number of sentinel nodes predicts nonsentinel node status in breast cancer patients.

Journal Article Breast J · 2005 Selective sentinel lymphadenectomy (SSL) has replaced axillary lymph node dissection (ALND) for many patients with early breast cancer and negative sentinel lymph nodes (SLNs). Yet many patients with a positive SLN are undergoing unnecessary ALND, as no fu ... Full text Link to item Cite

Internal mammary sentinel lymph node mapping for invasive breast cancer: implications for staging and treatment.

Journal Article Breast J · 2005 The optimal staging and treatment of the internal mammary nodes (IMNs) among patients with invasive breast cancer (IBC) is controversial. Although medial tumors have been reported to more commonly drain to IMNs, other variables predictive for IMN drainage ... Full text Link to item Cite

Risk factors for estrogen receptor-positive breast cancer.

Journal Article Arch Surg · January 2005 HYPOTHESIS: Some risk factors associated with breast cancer may be more predictive of estrogen receptor (ER)- positive than ER-negative tumors. DESIGN: Survey of patients enrolled in a study of breast cancer risk factors. SETTING: Community population in a ... Full text Link to item Cite

[18F]fluorodeoxyglucose-positron emission tomography in patients with medulloblastoma.

Journal Article Neurosurgery · December 2004 OBJECTIVE: We evaluated the [(18)F]fluorodeoxyglucose (FDG) accumulation during positron emission tomography (PET) in patients with medulloblastoma and examined the relationship of intensity of uptake with patient outcome after the initial scan. METHODS: M ... Full text Link to item Cite

Accuracy of selective sentinel lymphadenectomy after neoadjuvant chemotherapy: effect of clinical node status at presentation.

Journal Article J Am Coll Surg · December 2004 BACKGROUND: Both neoadjuvant chemotherapy and selective sentinel lymphadenectomy (SSL) are increasingly being used in treating primary breast cancer. It is important to determine whether SSL can be used after neoadjuvant chemotherapy and whether clinical n ... Full text Link to item Cite

Patterns of chromosomal alterations in breast ductal carcinoma in situ.

Journal Article Clin Cancer Res · August 1, 2004 PURPOSE: Ductal carcinoma in situ (DCIS) is thought to be a nonobligate precursor of invasive cancer. Genomic changes specific to pure DCIS versus invasive cancer, as well as alterations unique to individual DCIS subtypes, have not been fully defined. EXPE ... Full text Link to item Cite

Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma.

Journal Article Cancer · June 15, 2004 BACKGROUND: Lobular carcinoma in situ (LCIS) of the breast is considered a marker for an increased risk of carcinoma in both breasts. However, the frequent association of LCIS with invasive lobular carcinoma (ILC) suggests a precursor-product relation. The ... Full text Link to item Cite

Array-based comparative genomic hybridization of ductal carcinoma in situ and synchronous invasive lobular cancer.

Journal Article Hum Pathol · June 2004 It has been increasingly recognized that ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive cancer of the breast are often closely associated with one another. However, the genomic relationship between these histologically disti ... Full text Link to item Cite

Applying the neoadjuvant paradigm to ductal carcinoma in situ.

Journal Article Ann Surg Oncol · January 2004 Local treatment options for ductal carcinoma in situ (DCIS) are virtually identical to those for early invasive breast cancer, despite the fact that the survival from this condition is much higher. Our ability to more appropriately tailor therapy for DCIS ... Full text Link to item Cite

Neoadjuvant hormonal therapy for ductal carcinoma in situ: trial design and preliminary results.

Journal Article Ann Surg Oncol · January 2004 For some women, the treatment for ductal carcinoma in situ (DCIS) may be even more aggressive than treatments undertaken for early-stage invasive disease. Expectant management is not a tenable alternative, given that in a significant percentage of patients ... Full text Link to item Cite

Breast conservation surgery using nipple-areolar resection for central breast cancers.

Journal Article Arch Surg · January 2004 HYPOTHESIS: Resection of the nipple-areolar complex (NAC) for central breast cancers that involve the nipple or areola, with postoperative radiation therapy, adheres to the oncologic principles established for breast conservation surgery of other breast ca ... Full text Link to item Cite

Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis.

Journal Article Cancer Res · November 1, 2003 Invasive lobular and ductal breast tumors have distinct histologies and clinical presentation. Other than altered expression of E-cadherin, little is known about the underlying biology that distinguishes the tumor subtypes. We used cDNA microarrays to iden ... Link to item Cite

Magnetic resonance imaging in patients diagnosed with ductal carcinoma-in-situ: value in the diagnosis of residual disease, occult invasion, and multicentricity.

Journal Article Ann Surg Oncol · May 2003 BACKGROUND: Although magnetic resonance imaging (MRI) has been shown to be a sensitive imaging tool for invasive breast cancers, its utility in ductal carcinoma-in-situ (DCIS) of the breast remains controversial. We studied the performance of MRI in patien ... Full text Link to item Cite

Failure to harvest sentinel lymph nodes identified by preoperative lymphoscintigraphy in breast cancer patients.

Journal Article Breast J · 2003 Selective sentinel lymphadenectomy dissection has been demonstrated to have high predictive value for axillary staging in breast cancer patients. Preoperative lymphoscintigraphy can localize and facilitate the harvesting of sentinel lymph nodes (SNLs) with ... Full text Link to item Cite

Skin-sparing mastectomy and immediate breast reconstruction: a prospective cohort study for the treatment of advanced stages of breast carcinoma.

Journal Article Ann Surg Oncol · June 2002 BACKGROUND: Recent published series demonstrate the safety and effectiveness of skin-sparing mastectomy (SSM) with immediate reconstruction for the treatment of early-stage breast carcinoma. Although several reports have retrospectively evaluated outcomes ... Full text Link to item Cite

MRI phenotype is associated with response to doxorubicin and cyclophosphamide neoadjuvant chemotherapy in stage III breast cancer.

Journal Article Ann Surg Oncol · July 2001 BACKGROUND: The preferred management for women with stage II or locally advanced breast cancer (LABC) is neoadjuvant chemotherapy. Pathologic response to chemotherapy has been shown to be an excellent predictor of outcome. Surrogates that can predict patho ... Full text Link to item Cite

Analysis of bone marrow micrometastasis in primary breast cancer: Automated cellular imaging analysis in relation to quantitative RT-PCR and tumor clinicopathologic features

Journal Article Breast Cancer Research and Treatment · January 1, 2001 The presence of bone marrow micrometastasis (MM) has been reported to be an adverse prognostic indicator in primary breast cancer, and may be of value in adjuvant therapy decision-making. To date, MM detection has been pursued by a variety of cell-based an ... Cite

Genomic alterations in tubular breast carcinomas

Journal Article Human Pathology · January 1, 2001 Tubular carcinoma of the breast is a well-differentiated variant of invasive ductal carcinoma and has been shown to have an exceptionally favorable prognosis, as manifested by a low incidence of lymph node metastases and an excellent overall survival. It i ... Full text Cite

Reply.

Other J Cogn Neurosci · September 2000 Full text Link to item Cite

Current national health insurance coverage policies for breast and ovarian cancer prophylactic surgery.

Journal Article Ann Surg Oncol · June 2000 BACKGROUND: The efficacy of prophylactic mastectomy and oophorectomy in reducing breast and ovarian carcinoma has recently been reported in high-risk women. Because cost has become central to medical decision-making, this study was designed to evaluate cur ... Full text Link to item Cite

Management of ductal carcinoma in situ.

Journal Article Surg Clin North Am · October 1999 The dramatic increase in the incidence of ductal carcinoma in situ (DCIS) of the breast has made it imperative for all clinicians to develop a better understanding of this disease. Although this preinvasive form of breast cancer is not life-threatening, tr ... Full text Link to item Cite

Volume of resection in patients treated with breast conservation for ductal carcinoma in situ.

Journal Article Ann Surg Oncol · December 1998 BACKGROUND: The optimal treatment of ductal carcinoma in situ (DCIS) is one of the most controversial issues in the management of breast cancer. Identification of factors that affect the risk of local recurrence is very important as the incidence of DCIS i ... Full text Link to item Cite

Does the proven benefit of mammography extend to breast cancer patients over age 70?

Journal Article South Med J · June 1998 BACKGROUND: Prospective randomized studies show reduced breast cancer mortality among women offered mammographic screening; yet, few women 70 or older were represented in these trials. We examine the impact of mammography on stage at diagnosis of breast ca ... Full text Link to item Cite

Surgical pancreatic complications induced by L-asparaginase.

Journal Article J Pediatr Surg · June 1997 Pancreatitis has been noted to be a potential complication in 2% to 16% of patients undergoing treatment with L-asparaginase for a variety of pediatric neoplasms, but rarely has surgical intervention been necessary. The authors present two fulminant cases ... Full text Link to item Cite

Leiomyosarcoma in childhood and adolescence.

Journal Article Ann Surg Oncol · 1997 BACKGROUND: Few series of leiomyosarcoma in patients < 21 years of age have been reported. We reviewed our institutional experience with this neoplasm to learn disease characteristics, patterns of relapse, and outcome. METHODS: The records of 21 patients w ... Full text Link to item Cite

Distribution of the SGLT1 Na+/glucose cotransporter and mRNA along the crypt-villus axis of rabbit small intestine.

Journal Article Biochem Biophys Res Commun · December 31, 1991 The expression of the Na+/glucose cotransporter (SGLT1) mRNA and protein along the crypt-villus axis of the rabbit small intestine was examined using in situ hybridization and immunocytochemical techniques. We detected mRNA in the cells on the villus, but ... Full text Link to item Cite

Characterization of a Na+/glucose cotransporter cloned from rabbit small intestine.

Journal Article J Membr Biol · August 1989 The Na+/glucose cotransporter from rabbit intestinal brush border membranes has been cloned, sequenced, and expressed in Xenopus oocytes. Injection of cloned RNA into oocytes increased Na+/sugar cotransport by three orders of magnitude. In this study, we h ... Full text Link to item Cite