Scholars@Duke
Steven L Young

Selected Publications

Spaceflight induces changes in gene expression profiles linked to insulin and estrogen.

Journal Article Commun Biol · June 11, 2024 Organismal adaptations to spaceflight have been characterized at the molecular level in model organisms, including Drosophila and C. elegans. Here, we extend molecular work to energy metabolism and sex hormone signaling in mice and humans. We found spacefl ... Full text Link to item Cite

Transcriptomic changes in eutopic endometrium and ectopic lesions during endometriosis progression in a mouse model.

Journal Article F S Sci · May 2024 OBJECTIVE: To identify the transcriptomic changes of ectopic lesions and eutopic endometrial tissues during the progression of endometriosis, we performed transcriptomic analysis in the eutopic endometrium and ectopic lesions. DESIGN: Laboratory study. SET ... Full text Link to item Cite

Uterine Uptake of Estrogen and Progestogen-Based Radiotracers in Rhesus Macaques with Endometriosis.

Journal Article Mol Imaging Biol · April 2024 PURPOSE: Endometriosis is an estrogen-dependent disorder of menstruating primates where tissues similar to the inner lining of the uterus exist "ectopically" outside of the uterus. The ectopic endometrium, like the endometrium within the uterus, expresses ... Full text Link to item Cite

Society of Radiologists in Ultrasound Consensus on Routine Pelvic US for Endometriosis.

Journal Article Radiology · April 2024 Endometriosis is a prevalent and potentially debilitating condition that mostly affects individuals of reproductive age, and often has a substantial diagnostic delay. US is usually the first-line imaging modality used when patients report chronic pelvic pa ... Full text Link to item Cite

Nonsurgical approaches to the diagnosis and evaluation of endometriosis.

Journal Article Fertil Steril · February 2024 An inability to make the diagnosis of endometriosis or evaluate lesion response to treatment without surgery is a clear impediment to understanding the disease and to developing new therapies. The need is particularly strong for rASRM Stage 1 or 2 disease, ... Full text Link to item Cite

Meeting the demand for fertility services: the present and future of reproductive endocrinology and infertility in the United States.

Journal Article Fertil Steril · October 2023 The field of reproductive endocrinology and infertility (REI) is at a crossroads; there is a mismatch between demand for reproductive endocrinology, infertility and assisted reproductive technology (ART) services, and availability of care. This document's ... Full text Link to item Cite

Uterine uptake of estrogen and progestogen-based radiotracers in rhesus macaques with endometriosis.

Journal Article Res Sq · September 8, 2023 PURPOSE: Few investigations have examined the uptake of radiotracers that target the prominent sex-steroid receptors in the uterus across the menstrual cycle and with disease state. We aimed to determine if uptake of the radiotracers that target estrogen a ... Full text Link to item Cite

IMPACT OF SPERM SEPARATION DEVICES ON EMBRYOLOGY OUTCOMES.

Conference FERTILITY AND STERILITY · 2023 Cite

Effects of acute estradiol and progesterone on perimenstrual exacerbation of suicidal ideation and related symptoms: a crossover randomized controlled trial.

Journal Article Transl Psychiatry · December 30, 2022 Female suicide attempts peak peri-menstrually-around the onset of menses-when the ovarian steroids estradiol (E2) and progesterone (P4) fall rapidly. Given preclinical evidence that withdrawal from either E2 or P4 can provoke behaviors consistent with elev ... Full text Open Access Link to item Cite

The Estrogen Receptor α Cistrome in Human Endometrium and Epithelial Organoids.

Journal Article Endocrinology · September 1, 2022 Endometrial health is affected by molecular processes that underlie estrogen responses. We assessed estrogen regulation of endometrial function by integrating the estrogen receptor α (ESR1) cistromes and transcriptomes of endometrial biopsies taken from th ... Full text Link to item Cite

Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial.

Journal Article BMJ Open · June 17, 2022 INTRODUCTION: Infertility is a common complication of endometriosis. While in vitro fertilisation-embryo transfer (IVF) successfully treats endometriosis-associated infertility, there is some evidence that pregnancy rates may be diminished in women seeing ... Full text Open Access Link to item Cite

SIRT1 plays an important role in implantation and decidualization during mouse early pregnancy.

Journal Article Biol Reprod · June 13, 2022 Sirtuin 1 (SIRT1) is a member of the sirtuin family that functions to deacetylate both histones and non-histone proteins. Previous studies have identified significant SIRT1 upregulation in eutopic endometrium from infertile women with endometriosis. Howeve ... Full text Link to item Cite

Evaluation of endometrial receptivity and implantation failure.

Journal Article Curr Opin Obstet Gynecol · June 1, 2022 PURPOSE OF REVIEW: To succinctly review the basic mechanisms of implantation and luteal phase endometrial differentiation, the etiologies of impaired endometrial function and receptivity, and the current methods that exist to evaluate and treat impaired en ... Full text Link to item Cite

Progesterone Signaling in Endometrial Epithelial Organoids.

Journal Article Cells · May 27, 2022 For pregnancy to be established, uterine cells respond to the ovarian hormones, estrogen, and progesterone, via their nuclear receptors, the estrogen receptor (ESR1) and progesterone receptor (PGR). ESR1 and PGR regulate genes by binding chromatin at genes ... Full text Open Access Link to item Cite

Loss of MIG-6 results in endometrial progesterone resistance via ERBB2.

Journal Article Nat Commun · March 1, 2022 Female subfertility is highly associated with endometriosis. Endometrial progesterone resistance is suggested as a crucial element in the development of endometrial diseases. We report that MIG-6 is downregulated in the endometrium of infertile women with ... Full text Open Access Link to item Cite

Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium.

Journal Article J Clin Endocrinol Metab · February 17, 2022 CONTEXT: Progesterone resistance, a known pathologic condition associated with a reduced cellular response to progesterone and heightened estrogen responses, appears to have a normal physiologic role in mammalian reproduction. The molecular mechanism respo ... Full text Link to item Cite

Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation.

Journal Article Reprod Sci · February 2022 The Pre-IVF Treatment with a GnRH Antagonist in Women with Endometriosis (PREGnant) Trial (clinicaltrials.gov no. NCT04173169) was designed to test the hypothesis that 60-day pre-treatment with an oral GnRH antagonist in women with documented endometriosis ... Full text Open Access Link to item Cite

Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology.

Journal Article Front Immunol · 2022 Endometriosis is an estrogen dependent, chronic inflammatory disease characterized by the growth of endometrial lining outside of the uterus. Mast cells have emerged as key players in regulating not only allergic responses but also other mechanisms such as ... Full text Open Access Link to item Cite

RACIAL DISPARITIES IN ENDOMETRIOSIS SURGERY

Conference FERTILITY AND STERILITY · 2022 Cite

RACIAL DISPARITIES IN ABDOMINAL AND LAPAROSCOPIC MYOMECTOMIES

Conference FERTILITY AND STERILITY · 2022 Cite

IL-33 activates group 2 innate lymphoid cell expansion and modulates endometriosis.

Journal Article JCI Insight · December 8, 2021 Chronic inflammation and localized alterations in immune cell function are suspected to contribute to the progression of endometriosis and its associated symptoms. In particular, the alarmin IL-33 is elevated in the plasma, peritoneal fluid, and endometrio ... Full text Link to item Cite

Defining recurrent implantation failure: a profusion of confusion or simply an illusion?

Journal Article Fertil Steril · December 2021 Recurrent implantation failure (RIF) is a poorly defined clinical scenario marked by failure to achieve pregnancy after multiple embryo transfers. The causes and definitions of implantation failure are heterogeneous, posing limitations on study design as w ... Full text Link to item Cite

Poor Endometrial Proliferation After Clomiphene is Associated With Altered Estrogen Action.

Journal Article J Clin Endocrinol Metab · August 18, 2021 CONTEXT: Suboptimal endometrial thickening is associated with lower pregnancy rates and occurs in some infertile women treated with clomiphene. OBJECTIVE: To examine cellular and molecular differences in the endometrium of women with suboptimal vs optimal ... Full text Link to item Cite

Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis.

Journal Article Nat Commun · June 7, 2021 During early pregnancy in the mouse, nidatory estrogen (E2) stimulates endometrial receptivity by activating a network of signaling pathways that is not yet fully characterized. Here, we report that bone morphogenetic proteins (BMPs) control endometrial re ... Full text Link to item Cite

Diagnosis and treatment of luteal phase deficiency: a committee opinion.

Journal Article Fertil Steril · June 2021 Luteal phase deficiency (LPD) is a clinical diagnosis associated with an abnormal luteal phase length of ≤10 days. Potential etiologies of LPD include inadequate progesterone duration, inadequate progesterone levels, or endometrial progesterone resistance. ... Full text Link to item Cite

Genetic and epigenetic changes in the eutopic endometrium of women with endometriosis: association with decreased endometrial αvβ3 integrin expression.

Journal Article Mol Hum Reprod · May 29, 2021 About 40% of women with infertility and 70% of women with pelvic pain suffer from endometriosis. The pregnancy rate in women undergoing IVF with low endometrial integrin αvβ3 (LEI) expression is significantly lower compared to the women with high endometri ... Full text Link to item Cite

ARID1A and PGR proteins interact in the endometrium and reveal a positive correlation in endometriosis.

Journal Article Biochem Biophys Res Commun · April 23, 2021 Endometriosis is a disorder in which endometrial cells normally limited to the lining of the uterus proliferate outside the uterine cavity and can cause pelvic pain and infertility. ARID1A levels are significantly reduced in the eutopic endometrium from wo ... Full text Link to item Cite

Podocalyxin is a key negative regulator of human endometrial epithelial receptivity for embryo implantation.

Journal Article Hum Reprod · April 20, 2021 STUDY QUESTION: How is endometrial epithelial receptivity, particularly adhesiveness, regulated at the luminal epithelial surface for embryo implantation in the human? SUMMARY ANSWER: Podocalyxin (PCX), a transmembrane protein, was identified as a key nega ... Full text Link to item Cite

Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment.

Journal Article FASEB J · February 2021 Though endometriosis and infertility are clearly associated, the pathophysiological mechanism remains unclear. Previous work has linked endometrial ARID1A loss to endometriosis-related endometrial non-receptivity. Here, we show in mice that ARID1A binds an ... Full text Link to item Cite

IL-33 activates ILC2 expansion and modulates endometriosis

Conference JOURNAL OF IMMUNOLOGY · 2021 Cite

WNK1 regulates uterine homeostasis and its ability to support pregnancy.

Journal Article JCI Insight · November 19, 2020 WNK1 (with no lysine [K] kinase 1) is an atypical kinase protein ubiquitously expressed in humans and mice. A mutation in its encoding gene causes hypertension in humans, which is associated with abnormal ion homeostasis. WNK1 is critical for in vitro deci ... Full text Link to item Cite

Human Endometrial Transcriptome and Progesterone Receptor Cistrome Reveal Important Pathways and Epithelial Regulators.

Journal Article J Clin Endocrinol Metab · April 1, 2020 CONTEXT: Poor uterine receptivity is one major factor leading to pregnancy loss and infertility. Understanding the molecular events governing successful implantation is hence critical in combating infertility. OBJECTIVE: To define Progesterone Receptor (PG ... Full text Link to item Cite

Large, Non-Cavity Distorting Intramural Leiomyomas Decrease Leukemia Inhibitory Factor in the Secretory Phase Endometrium.

Journal Article Reprod Sci · February 2020 Despite mounting evidence that large intramural leiomyomas decrease fecundity during in vitro fertilization cycles, few studies have demonstrated a mechanism for this impact. We hypothesize that large intramural leiomyomas (IM) decrease the expression of e ... Full text Link to item Cite

Neutrophil recruitment and function in endometriosis patients and a syngeneic murine model.

Journal Article FASEB J · January 2020 Endometriosis is a chronic inflammatory, gynecological disease characterized by the presence of endometrial-like tissue lesions outside of the uterus. Neutrophils are elevated in the systemic circulation and peritoneal fluid of endometriosis patients; howe ... Full text Link to item Cite

Endocrinology of Implantation

Chapter · January 1, 2020 Embryo implantation is dependent on the actions of estradiol and progesterone. Induced cellular changes through the menstrual cycle create a receptive microenvironment to allow apposition, attachment, and invasion of embryo. A complex communication between ... Full text Cite

Diagnostic and therapeutic options in recurrent implantation failure.

Journal Article F1000Res · 2020 Recurrent implantation failure (RIF) is an uncommon, imprecisely defined clinical disorder characterized by failure to achieve pregnancy after repeated embryo transfers. The diverse etiologies and incomplete understanding of RIF provide significant diagnos ... Full text Link to item Cite

Differential Expression of KRAS and SIRT1 in Ovarian Cancers with and Without Endometriosis.

Journal Article Reprod Sci · January 2020 Accumulating research shows that ovarian cancer progression can be influenced by both gene mutations and endometriosis. However, the exact mechanism at hand is poorly understood. In the current study, we explored the expression of KRAS and SIRT1, two genes ... Full text Link to item Cite

Unexplained recurrent pregnancy loss and unexplained infertility: twins in disguise.

Journal Article Hum Reprod Open · 2020 STUDY QUESTION: Is B-cell CLL/lymphoma 6 (BCL6) endometrial expression, a surrogate biomarker of endometriosis, elevated in women with unexplained recurrent pregnancy loss (uRPL) and unexplained infertility (UI) compared to fertile subjects? SUMMARY ANSWER ... Full text Link to item Cite

Endocrinology of Implantation

Chapter · October 9, 2019 Embryo implantation is dependent on the actions of estradiol and progesterone. Induced cellular changes through the menstrual cycle create a receptive microenvironment to allow apposition, attachment, and invasion of embryo. A complex communication between ... Full text Cite

Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature.

Journal Article JCI Insight · September 19, 2019 With multifactorial etiologies, combined with disease heterogeneity and a lack of suitable diagnostic markers and therapy, endometriosis remains a major reproductive health challenge. Extracellular vesicles (EVs) have emerged as major contributors of disea ... Full text Link to item Cite

Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium.

Journal Article FASEB J · July 2019 The pioneer forkhead box (FOX)A2 transcription factor is specifically expressed in the glands of the uterus, which are central to endometrial function and fertility. In mice, FOXA2 is a critical regulator of uterine gland development in the neonate and gla ... Full text Link to item Cite

Msx Homeobox Genes Act Downstream of BMP2 to Regulate Endometrial Decidualization in Mice and in Humans.

Journal Article Endocrinology · July 1, 2019 Endometrial stromal cells differentiate to form decidual cells in a process known as decidualization, which is critical for embryo implantation and successful establishment of pregnancy. We previously reported that bone morphogenetic protein 2 (BMP2) media ... Full text Link to item Cite

What exactly is endometrial receptivity?

Journal Article Fertil Steril · April 2019 Endometrial receptivity is a complex process that provides the embryo with the opportunity to attach, invade, and develop, culminating in a new individual and continuation of the species. The window of implantation extends 3-6 days within the secretory pha ... Full text Link to item Cite

Loss of HDAC3 results in nonreceptive endometrium and female infertility.

Journal Article Sci Transl Med · January 9, 2019 Endometriosis is a disease in which tissue that normally grows inside the uterus grows outside the uterus and causes chronic pelvic pain and infertility. However, the exact mechanisms of the pathogenesis of endometriosis-associated infertility are unknown. ... Full text Link to item Cite

Structure, Function, and Evaluation of the Female Reproductive Tract

Chapter · January 1, 2019 The endometrium develops within the uterus, originating from the urogenital ridge early in development. This mucosal lining consists of epithelial and stromal cells invested with a specialized vasculature that matures at puberty and orchestrates cyclic men ... Full text Cite

FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation.

Journal Article PLoS Genet · November 2018 Successful embryo implantation requires a receptive endometrium. Poor uterine receptivity can account for implantation failure in women who experience recurrent pregnancy loss or multiple rounds of unsuccessful in vitro fertilization cycles. Here, we demon ... Full text Link to item Cite

SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh.

Journal Article Nat Commun · October 24, 2018 Mammalian pregnancy depends on the ability of the uterus to support embryo implantation. Previous studies reveal the Sox17 gene as a downstream target of the Pgr-Gata2-dependent transcription network that directs genomic actions in the uterine endometrium ... Full text Link to item Cite

Effects of histone methyltransferase inhibition in endometriosis.

Journal Article Biol Reprod · August 1, 2018 Although the histone methyltransferase EZH2 and its product H3K27me3 are well studied in cancer, little is known about their role and potential as therapeutic targets in endometriosis. We have previously reported that endometriotic lesions are characterize ... Full text Link to item Cite

Elevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis.

Journal Article Fertil Steril · June 2018 OBJECTIVE: To test adrenomedullin (Adm, ADM) as a downstream target of signal transducer and activator of transcription 3 (STAT3) in endometrial cells and to test midregional proadrenomedullin (MR-proADM) as a biomarker of endometriosis. DESIGN: Cross-sect ... Full text Link to item Cite

RBPJ mediates uterine repair in the mouse and is reduced in women with recurrent pregnancy loss.

Journal Article FASEB J · May 2018 Unexplained recurrent pregnancy loss (uRPL) is associated with repeated embryo loss and endometrial repair with elevated endometrial expression of inflammatory cytokines, including IFN-γ. Notch signaling through its transcription factor recombination signa ... Full text Link to item Cite

Evaluation, validation and refinement of noninvasive diagnostic biomarkers for endometriosis (ENDOmarker): A protocol to phenotype bio-specimens for discovery and validation.

Journal Article Contemp Clin Trials · May 2018 OBJECTIVE: Endometriosis is a chronic, estrogen dependent condition that affects 5-10% of reproductive aged women and is associated with pelvic pain and infertility. As the approach to therapy shifts from surgical ablation to pharmacological control, a non ... Full text Link to item Cite

Overexpression of Four Joint Box-1 Protein (FJX1) in Eutopic Endometrium From Women With Endometriosis.

Journal Article Reprod Sci · February 2018 The four jointed box 1 (FJX1) is a regulator of angiogenesis, and the levels of FJX1 are increased in several types of cancer. Angiogenesis plays a critical role in endometrial growth as well as in several gynecologic disorders including endometriosis. How ... Full text Link to item Cite

The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid secretory phase.

Journal Article J Reprod Immunol · February 2018 The control of complement activation within embryo-endometrium environment is critical for embryo survival. Cell evasion from complement attack requires interaction of complement regulatory proteins (CRPs) with cell adhesion αvβ3 integrin. We aim to compar ... Full text Link to item Cite

Steroid hormones and endometriosis

Journal Article Current Women's Health Reviews · January 1, 2018 Background: The complexity of endometriosis pathophysiology, the diversity of disease phenotypes, and the fact that the disease only occurs in menstruating primates have limited the pace of progress in our understanding of this very common and sometimes de ... Full text Cite

Early Endometriosis in Females Is Directed by Immune-Mediated Estrogen Receptor α and IL-6 Cross-Talk.

Journal Article Endocrinology · January 1, 2018 Endometriosis is a gynecological disease that negatively affects the health of 1 in 10 women. Although more information is known about late stage disease, the early initiation of endometriosis and lesion development is poorly understood. Herein, we use a u ... Full text Link to item Cite

Interleukin-33 Modulates Inflammation in Endometriosis.

Conference REPRODUCTIVE SCIENCES · 2018 Cite

Interleukin-33 modulates inflammation in endometriosis.

Journal Article Sci Rep · December 20, 2017 Endometriosis is a debilitating condition that is categorized by the abnormal growth of endometrial tissue outside the uterus. Although the pathogenesis of this disease remains unknown, it is well established that endometriosis patients exhibit immune dysf ... Full text Link to item Cite

Adrenomedullin improves fertility and promotes pinopodes and cell junctions in the peri-implantation endometrium.

Journal Article Biol Reprod · September 1, 2017 Implantation is a complex event demanding contributions from both embryo and endometrium. Despite advances in assisted reproduction, endometrial receptivity defects persist as a barrier to successful implantation in women with infertility. We previously de ... Full text Link to item Cite

Effect of randomized serum progesterone concentration on secretory endometrial histologic development and gene expression.

Journal Article Hum Reprod · September 1, 2017 STUDY QUESTION: What doses of secretory phase progesterone (P) in women are associated with altered endometrial structure and/or function? SUMMARY ANSWER: Consistently delayed histological maturation was seen at the lowest tested daily P dose (2.5 mg), whe ... Full text Link to item Cite

KRAS Activation and over-expression of SIRT1/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance.

Journal Article Sci Rep · July 28, 2017 Endometriosis is an inflammatory condition that is associated with progesterone resistance and cell proliferation, resulting in pain, infertility and pregnancy loss. We previously demonstrated phosphorylation of STAT3 in eutopic endometrium of infertile wo ... Full text Link to item Cite

A balancing act: RNA binding protein HuR/TTP axis in endometriosis patients.

Journal Article Sci Rep · July 19, 2017 Endometriosis, a major reproductive pathology affecting 8-10% of women is characterized by chronic inflammation and immune dysfunction. Human antigen R (HuR) and Tristetraprolin (TTP) are RNA binding proteins that competitively bind to cytokines involved i ... Full text Link to item Cite

Endometrial receptivity: lessons from systems biology and candidate gene studies of endometriosis.

Journal Article Minerva Ginecol · February 2017 Endometrial receptivity is essential for embryo implantation and ongoing successful pregnancy. The temporal "window" during which the endometrium allows implantation, known as window of implantation (WOI), which is, characterized alteration of many genes. ... Full text Link to item Cite

Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4.

Journal Article J Clin Endocrinol Metab · January 1, 2017 CONTEXT: Endometriosis results in aberrant gene expression in the eutopic endometrium (EuE) and subsequent progesterone resistance. MicroRNA (miR) microarray data in a baboon model of endometriosis showed an increased expression of miR-29c. OBJECTIVES: To ... Full text Link to item Cite

Distribution of the FMR1 gene in females by race/ethnicity: women with diminished ovarian reserve versus women with normal fertility (SWAN study).

Journal Article Fertil Steril · January 2017 OBJECTIVE: To study whether reported, but inconsistent, associations between the FMR1 CGG repeat lengths in the intermediate, high normal, or low normal range differentiate women diagnosed with diminished ovarian reserve (DOR) from population controls and ... Full text Link to item Cite

Pro-Inflammatory Effects of IL-33 In Endometriosis.

Conference REPRODUCTIVE SCIENCES · 2017 Cite

RNA Binding Protein, HuR/TTP Axis in Endometriosis.

Conference REPRODUCTIVE SCIENCES · 2017 Cite

Immune-inflammation gene signatures in endometriosis patients.

Journal Article Fertil Steril · November 2016 OBJECTIVE: To determine if the molecular profiles of endometriotic lesions contain informative measures of inflammation and immune dysfunction that may contribute to better understanding of the interplay between immune dysfunction and inflammation and thei ... Full text Link to item Cite

Introduction: Reproductive immunology: checkered past and bright future.

Journal Article Fertil Steril · September 1, 2016 The immune system plays a critical role in pregnancy establishment and maintenance, but application of immunological principles to the treatment of infertility and pregnancy loss has had a checkered past. Improving knowledge in this area holds great promis ... Full text Link to item Cite

Endometrial BCL6 Overexpression in Eutopic Endometrium of Women With Endometriosis.

Journal Article Reprod Sci · September 2016 The objective of this study was to examine B-cell CLL/lymphoma 6 (BCL6) expression in human eutopic endometrium across the menstrual cycle in women with and without endometriosis and to establish a cutoff for future studies. This design was a series of cas ... Full text Link to item Cite

Protein Inhibitor of Activated STAT3 (PIAS3) Is Down-Regulated in Eutopic Endometrium of Women with Endometriosis.

Journal Article Biol Reprod · July 2016 Endometriosis is a major cause of chronic pelvic pain and infertility. Activation of STAT3 appears central to the inflammatory phenotype of eutopic endometrium in women with endometriosis. However, the molecular mechanism by which this occurs remains unkno ... Full text Link to item Cite

Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients.

Journal Article Fertil Steril · April 2016 OBJECTIVE: To determine the impact of endometriotic lesion removal on local and systemic inflammation. DESIGN: Multiplex cytokine analysis on samples from endometriosis patients before surgery, 2 weeks after surgery, and 3 months after surgery. SETTING: Ac ... Full text Link to item Cite

cAMP-Response Element-Binding 3-Like Protein 1 (CREB3L1) is Required for Decidualization and its Expression is Decreased in Women with Endometriosis.

Journal Article Curr Mol Med · 2016 Endometriosis is a major cause of infertility and pelvic pain, affecting more than 10% of reproductive-aged women. Progesterone resistance has been observed in the endometrium of women with this disease, as evidenced by alterations in progesterone-responsi ... Full text Link to item Cite

Evaluation of IL-33 in the Pathogenesis of Endometriosis.

Conference REPRODUCTIVE SCIENCES · 2016 Cite

Altered expression of microRNA-451 in eutopic endometrium of baboons (Papio anubis) with endometriosis.

Journal Article Hum Reprod · December 2015 STUDY QUESTION: Are microRNAs (miRs) altered in the eutopic endometrium (EuE) of baboons following the induction of endometriosis? SUMMARY ANSWER: Induction of endometriosis causes significant changes in the expression of eight miRs, including miR-451, in ... Full text Link to item Cite

IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors.

Journal Article J Immunol · September 15, 2015 Endometriosis is a chronic, inflammatory disease characterized by the growth of endometrial tissue in aberrant locations outside the uterus. Neoangiogenesis or establishment of new blood supply is one of the fundamental requirements of endometriotic lesion ... Full text Link to item Cite

ARID1A Is Essential for Endometrial Function during Early Pregnancy.

Journal Article PLoS Genet · September 2015 AT-rich interactive domain 1A gene (ARID1A) loss is a frequent event in endometriosis-associated ovarian carcinomas. Endometriosis is a disease in which tissue that normally grows inside the uterus grows outside the uterus, and 50% of women with endometrio ... Full text Link to item Cite

Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis.

Journal Article Hum Reprod · May 2015 STUDY QUESTION: Are STAT3 signaling molecules differentially expressed in endometriosis? SUMMARY ANSWER: Levels of phospho-STAT3 and HIF1A, its downstream signaling molecule, are significantly higher in eutopic endometrium from women with endometriosis whe ... Full text Link to item Cite

Endometrial CXCL13 expression is cycle regulated in humans and aberrantly expressed in humans and Rhesus macaques with endometriosis.

Journal Article Reprod Sci · April 2015 C-X-C ligand 13 (CXCL13), a regulator of mucosal immunity, is secreted by human endometrial epithelium and may be involved in embryo implantation. However, cyclic expression of human endometrial CXCL13 in health and disease is not well studied. This study ... Full text Link to item Cite

Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women.

Journal Article J Acquir Immune Defic Syndr · April 1, 2015 : A comparative analysis of cellular and soluble markers of immune activation in HIV-infected women on combination antiretroviral therapy showed that the upper genital tract (UGT) compared to the lower female genital tract was characterized by higher frequ ... Full text Link to item Cite

Decreased Notch pathway signaling in the endometrium of women with endometriosis impairs decidualization.

Journal Article J Clin Endocrinol Metab · March 2015 CONTEXT: Endometriosis is a common gynecological disease affecting one in 10 women of reproductive age and is a major cause of pelvic pain and impaired fertility. Endometrial stromal cells of women with endometriosis exhibit a reduced response to in vitro ... Full text Link to item Cite

Progesterone and the luteal phase: a requisite to reproduction.

Journal Article Obstet Gynecol Clin North Am · March 2015 Progesterone production from the corpus luteum is critical for natural reproduction. Progesterone supplementation seems to be an important aspect of any assisted reproductive technology treatment. Luteal phase deficiency in natural cycles is a plausible ca ... Full text Link to item Cite

Ancient transposable elements transformed the uterine regulatory landscape and transcriptome during the evolution of mammalian pregnancy.

Journal Article Cell Rep · February 3, 2015 A major challenge in biology is determining how evolutionarily novel characters originate; however, mechanistic explanations for the origin of new characters are almost completely unknown. The evolution of pregnancy is an excellent system in which to study ... Full text Link to item Cite

Endocannabinoid regulation in human endometrium across the menstrual cycle.

Journal Article Reprod Sci · January 2015 Humans produce endogenous cannabinoids (endocannabinoids), a group of molecules that activate the same receptors as tetrahydrocannabinol. Endocannabinoids play important roles in reproduction in multiple species, but data in human endometrium are limited. ... Full text Link to item Cite

Characterization of GAB1 expression over the menstrual cycle in women with and without polycystic ovarian syndrome provides a new insight into its pathophysiology.

Journal Article J Clin Endocrinol Metab · November 2014 CONTEXT: In a previous microarray analysis, GRB2-associated binding protein 1 (GAB1), a docking protein closely related to the insulin receptor substrate, was down-regulated in endometrium of women with polycystic ovary syndrome (PCOS). OBJECTIVE: The obje ... Full text Link to item Cite

Resveratrol and endometrium: a closer look at an active ingredient of red wine using in vivo and in vitro models.

Journal Article Reprod Sci · November 2014 Resveratrol is a natural phytoestrogen with antiproliferative properties present in red wine, grapes, and berries. Published reports on the effects of resveratrol in human endometrial function are limited. The objective of this study was to investigate the ... Full text Link to item Cite

AMH in women with diminished ovarian reserve: potential differences by FMR1 CGG repeat level.

Journal Article J Assist Reprod Genet · October 2014 PURPOSE: We explored whether AMH, as a surrogate for oocyte supply, varies by FMR1 genotype in women diagnosed with diminished ovarian reserve (DOR), a subset of the Primary Ovarian Insufficiency phenotype. Research is inconsistent on the relationship betw ... Full text Link to item Cite

Characterization of uterine NK cells in women with infertility or recurrent pregnancy loss and associated endometriosis.

Journal Article Am J Reprod Immunol · September 2014 PROBLEM: Uterine natural killer cells (uNK) have been thought to play a key role in endometriosis and infertility. We investigated the expression of CD56, CD16, and NKp46 in endometrial tissues from 61 women with unexplained recurrent pregnancy loss (uRPL) ... Full text Link to item Cite

Homeostasis imbalance in the endometrium of women with implantation defects: the role of estrogen and progesterone.

Journal Article Semin Reprod Med · September 2014 Embryo implantation is regulated by an inflammatory process in response to sequential exposure to estrogen and progesterone, followed by resolution and repair. The actions of estrogen and progesterone on these inflammatory processes are tightly and recipro ... Full text Link to item Cite

Endometrial receptivity and intrauterine adhesive disease.

Journal Article Semin Reprod Med · September 2014 Intrauterine adhesions (IUA) can occur after mechanical or infectious injury to the endometrium. Normal endometrial repair occurs without scar formation; however, in some women, these normal repair mechanisms are aberrant, resulting in IUA formation. The e ... Full text Link to item Cite

A review of endometrium and implantation.

Journal Article Semin Reprod Med · September 2014 Full text Link to item Cite

Does the endometrium synthesize progesterone?

Conference Fertility and Sterility · September 2014 Full text Cite

The impact of FMR1 carrier testing in reproductive decision-making

Conference Fertility and Sterility · September 2014 Full text Cite

A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF.

Journal Article J Clin Invest · August 2014 A 30-year-old primigravid (G1P000) female with infertility secondary to her partner's oligospermia and her chronic anovulation presented 13 days after an oocyte retrieval for in vitro fertilization (IVF) with a positive home pregnancy test, abdominal diste ... Full text Link to item Cite

Expression of the transmembrane mucins, MUC1, MUC4 and MUC16, in normal endometrium and in endometriosis.

Journal Article Hum Reprod · August 2014 STUDY QUESTION: Are the transmembrane mucins, MUC1, MUC4 and MUC16, differentially expressed in endometriosis compared with normal endometrium? SUMMARY ANSWER: This study revealed that transmembrane mucin expression does not vary significantly in normal en ... Full text Link to item Cite

Peri-implantation intercourse lowers fecundability.

Journal Article Fertil Steril · July 2014 OBJECTIVE: To determine the impact of sexual intercourse around the time of implantation on the probability of achieving a pregnancy. DESIGN: Time-to-pregnancy cohort using day-specific probability of pregnancy modeling to account for intercourse during th ... Full text Link to item Cite

Prospective assessment of midsecretory endometrial leukemia inhibitor factor expression versus ανβ3 testing in women with unexplained infertility.

Journal Article Fertil Steril · June 2014 OBJECTIVE: To evaluate endometrial leukemia inhibitor factor (LIF) expression as a marker of endometrial receptivity in women with unexplained infertility (UI). DESIGN: Prospective case-control study. SETTING: University-associated infertility clinics. PAT ... Full text Link to item Cite

CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis.

Journal Article PLoS One · 2014 Endometriosis, defined as the presence of endometrial cells outside of the uterine cavity, is a major cause of infertility and pelvic pain, afflicting more than 10% of reproductive age women. Endometriosis is a chronic inflammatory disease and lipopolysacc ... Full text Link to item Cite

Bisphenol A exposure alters developmental gene expression in the fetal rhesus macaque uterus.

Journal Article PLoS One · 2014 Bisphenol A (BPA) exposure results in numerous developmental and functional abnormalities in reproductive organs in rodent models, but limited data are available regarding BPA effects in the primate uterus. To determine if maternal oral BPA exposure affect ... Full text Link to item Cite

COUP-TFII regulates human endometrial stromal genes involved in inflammation.

Journal Article Mol Endocrinol · December 2013 Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII; NR2F2) is an orphan nuclear receptor involved in cell-fate specification, organogenesis, angiogenesis, and metabolism. Ablation of COUP-TFII in the mouse uterus causes infertility due ... Full text Link to item Cite

Oestrogen and progesterone action on endometrium: a translational approach to understanding endometrial receptivity.

Journal Article Reprod Biomed Online · November 2013 Embryo attachment and implantation is critical to successful reproduction of all eutherian mammals, including humans; a better understanding of these processes could lead to improved infertility treatments and novel contraceptive methods. Experience with a ... Full text Link to item Cite

WNT4 acts downstream of BMP2 and functions via β-catenin signaling pathway to regulate human endometrial stromal cell differentiation.

Journal Article Endocrinology · January 2013 Differentiation of endometrial stromal cells into decidual cells is a prerequisite for successful embryo implantation. Our previous studies in the mouse have shown that bone morphogenetic protein 2 (BMP2), a morphogen belonging to the TGFβ superfamily, is ... Full text Link to item Cite

Elevated prevalence of 35-44 FMR1 trinucleotide repeats in women with diminished ovarian reserve.

Journal Article Reprod Sci · November 2012 INTRODUCTION: Fragile X premutations are associated with primary ovarian insufficiency when the patient presents with amenorrhea, but the fragile X mental retardation 1 (FMR1) CGG repeat count among cycling women with low ovarian reserve (diminished ovaria ... Full text Link to item Cite

Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation.

Journal Article J Biol Chem · October 5, 2012 Progesterone acting through the progesterone receptor (PR) and its coregulators prepares the human endometrium for receptivity to embryo implantation and maintains pregnancy. The menstrual cycle-dependent expression of melanoma antigen-A11 (MAGE-11) in the ... Full text Link to item Cite

Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model.

Journal Article Endocrinology · August 2012 Endometriosis results from ectopic invasion of endometrial tissue within the peritoneal cavity. Aberrant levels of the estrogen receptor (ER), ERα and ERβ, and higher incidence of autoimmune disorders are observed in women with endometriosis. An immunocomp ... Full text Link to item Cite

G protein-coupled estrogen receptor (GPER) expression in normal and abnormal endometrium.

Journal Article Reprod Sci · July 2012 Rapid estrogen effects are mediated by membrane receptors, and evidence suggests a role for both a membrane-associated form of estrogen receptor alpha (ESR1; ERα) and G-protein coupled receptor 30 (GPER; GPR30). Considering estrogen's importance in endomet ... Full text Link to item Cite

Pathophysiology of Infertility in Endometriosis

Chapter · January 25, 2012 Endometriosis is a disease affecting up to 10% of reproductive-aged women, but contributing to the majority of cases of pelvic pain and infertility. The association between infertility and mild endometriosis remains controversial, despite multiple lines of ... Full text Cite

Longitudinal anti-müllerian hormone in women with polycystic ovary syndrome: an acupuncture randomized clinical trial.

Journal Article Evid Based Complement Alternat Med · 2012 Others have studied acupuncture treatment for polycystic ovary syndrome (PCOS). Anti-müllerian hormone (AMH) is positively correlated with the ovarian follicle pool, thus making it a useful ovarian reserve measure. AMH is elevated in women with PCOS and ha ... Full text Link to item Cite

Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.

Journal Article J Clin Endocrinol Metab · June 2011 CONTEXT: Polycystic ovary syndrome (PCOS), the most common endocrinopathy of reproductive-aged women, is characterized by ovulatory dysfunction and hyperandrogenism. OBJECTIVE: The aim was to compare gene expression between endometrial samples of normal fe ... Full text Link to item Cite

Abstract 362: Comparison of Mig-6 and hormone receptor expression to BMI as predictors of responsiveness to progestin therapy for endometrial hyperplasia and cancer

Conference Cancer Research · April 15, 2011 AbstractObjectives: Mitogen-inducible gene 6 (Mig-6) is an immediate early response gene that can be induced by stressful stimuli and mitogens, including hormones and growth factors. Ablation of Mig-6 leads ... Full text Cite

Inter-laboratory validation of the measurement of follicle stimulating hormone (FSH) after various lengths of frozen storage.

Journal Article Reprod Biol Endocrinol · November 29, 2010 BACKGROUND: Serum follicle stimulating hormone (FSH) levels are used clinically to evaluate infertility, pituitary and gonadal disorders. With increased frequency of research collaborations across institutions, it is essential that inter-laboratory validat ... Full text Link to item Cite

Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis.

Journal Article Mol Hum Reprod · April 2010 Pregnancy is dependent upon the endometrium acquiring a receptive phenotype that facilitates apposition, adhesion and invasion of a developmentally competent embryo. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry of mid-secre ... Full text Link to item Cite

Progesterone function in human endometrium: clinical perspectives.

Journal Article Semin Reprod Med · January 2010 Progesterone is essential for endometrial receptivity and successful establishment of pregnancy. Either an insufficient progesterone concentration or an insufficient response to progesterone, therefore can lead to infertility and pregnancy loss. Assessment ... Full text Link to item Cite

Effects of variations in serum estradiol concentrations on secretory endometrial development and function in experimentally induced cycles in normal women.

Journal Article Fertil Steril · December 2009 Eighteen normal women underwent pituitary down-regulation with leuprolide, followed by a 10-day treatment with 0.2 mg/d transdermal estradiol (E(2)) with subsequent allocation to one of two 10-day estradiol regimens plus 40 mg daily intramuscular P: suprap ... Full text Link to item Cite

Proteomic analysis of the luteal endometrial secretome.

Journal Article Reprod Sci · September 2009 Endometrium attains a secretory architecture in preparation for embryo implantation, but the identity of most endometrial secretory products remains unknown. Our objective was to characterize the endometrial secretome and compare protein expression between ... Full text Link to item Cite

The ''toll'' of labor.

Journal Article Reprod Sci · September 2009 Full text Link to item Cite

Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease.

Journal Article Proc Natl Acad Sci U S A · May 26, 2009 Normal endometrial function requires a balance of progesterone (P4) and estrogen (E2) effects. An imbalance caused by increased E2 action and/or decreased P4 action can result in abnormal endometrial proliferation and, ultimately, endometrial adenocarcinom ... Full text Link to item Cite

Cyclic regulation of transcription factor C/EBP beta in human endometrium.

Journal Article Reprod Biol Endocrinol · February 17, 2009 BACKGROUND: The transcription factor CCAAT/enhancer-binding protein (C/EBP) beta is a critical mediator of murine endometrial function during embryo implantation. Our objective is to characterize changes in C/EBP beta mRNA abundance and protein localizatio ... Full text Link to item Cite

17beta-Estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia.

Journal Article J Clin Invest · December 2008 Normal airways homeostatically regulate the volume of airway surface liquid (ASL) through both cAMP- and Ca2+-dependent regulation of ion and water transport. In cystic fibrosis (CF), a genetic defect causes a lack of cAMP-regulated CFTR activity, leading ... Full text Link to item Cite

Endometrial development and function in experimentally induced luteal phase deficiency.

Journal Article J Clin Endocrinol Metab · October 2008 CONTEXT: It is generally assumed that delayed endometrial development observed in luteal phase deficiency (LPD) is the result of abnormally low progesterone (P) levels. This hypothesis has never been tested by direct experiment. OBJECTIVE: Our objective wa ... Full text Link to item Cite

Nuclear pore complex proteins mark the implantation window in human endometrium.

Journal Article J Cell Sci · June 15, 2008 Nucleolar channel systems (NCSs) are membranous organelles appearing transiently in the epithelial cell nuclei of postovulatory human endometrium. Their characterization and use as markers for a healthy receptive endometrium have been limited because they ... Full text Link to item Cite

Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation.

Journal Article Mol Hum Reprod · February 2008 The androgen receptor (AR) is a ligand-activated transcription factor of the male and female reproductive tracts whose activity is modulated by coregulator binding. We recently identified melanoma antigen gene protein-11 (MAGE-11) of the MAGEA gene family ... Full text Link to item Cite

Cyclic regulation of T-Bet and GATA-3 in human endometrium.

Journal Article Reprod Sci · January 2008 Endometrial cytokine expression is poorly understood. T-Bet and GATA-3 regulate cytokine expression in T-lymphocytes. Previous work has demonstrated expression of T-Bet in human endometrium. Changes in human endometrial T-Bet and GATA-3 mRNA and protein ex ... Full text Link to item Cite

Endometrial complement: Physiology and pathophysiology

Chapter · January 1, 2008 The complement system is an evolutionarily ancient facet of the human immune system that plays a profound and pleiotropic role in the immune response. Complement was among the first immune system components described by the first experimental immunologists ... Cite

Endocannabinoid regulation in human endometrium

Conference REPRODUCTIVE SCIENCES · 2008 Cite

Cyclic regulation of transcription factor C/EBPβ in human endometrium

Conference Fertility and Sterility · September 2007 Full text Cite

P-395

Conference Fertility and Sterility · September 2006 Full text Cite

O-90

Conference Fertility and Sterility · September 2006 Full text Cite

O-56

Conference Fertility and Sterility · September 2006 Full text Cite

Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women.

Journal Article Reprod Biol Endocrinol · 2006 Endometriosis is a disorder that affects 5% of the normal population but is present in up to 40% of women with pelvic pain and/or infertility. Recent evidence suggests that the endometrium of women with endometriosis exhibits progesterone insensitivity. On ... Full text Link to item Cite

Cyclic regulation of epithelial T-Bet expression in human endometrium

Conference JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION · 2006 Cite

17Beta-estradiol suppresses TLR3-induced cytokine and chemokine production in endometrial epithelial cells.

Journal Article Reprod Biol Endocrinol · December 29, 2005 BACKGROUND: The human endometrium is an important site for contact between the host and pathogens ascending the reproductive tract, and thus plays an important role in female reproductive tract immunity. Previous work in our laboratory has suggested that T ... Full text Link to item Cite

Adhesion Molecule Expression in Human Fallopian Tube

Conference Fertility and Sterility · September 2005 Full text Cite

Identification, characterization, and evolution of a primate beta-defensin gene cluster.

Journal Article Genes Immun · May 2005 Defensins are members of a large diverse family of cationic antimicrobial peptides that share a signature pattern consisting of six conserved cysteine residues. Defensins have a wide variety of functions and their disruption has been implicated in various ... Full text Link to item Cite

Human endometrial epithelial cells cyclically express Toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA.

Journal Article Hum Immunol · May 2005 Toll-like receptor 3 (TLR3) responds to dsRNA, a product of most viral life cycles, and initiates production of proinflammatory and antiviral cytokines. The role of TLR3 in human mucosal immunity of the endometrium has not been examined. The effects of TLR ... Full text Link to item Cite

Hormonal regulation of TLR3-induced responses

Conference FASEB JOURNAL · 2005 Cite

U1 RNA induces innate immunity signaling.

Journal Article Arthritis Rheum · September 2004 OBJECTIVE: The U1-70-kd RNP is a prominent target of autoimmunity in connective tissue diseases. In this study, we explored whether its endogenous ligand, U1 RNA, mediates a proimmune signal and may be immunogenic. METHODS: We assayed the proliferation of ... Full text Link to item Cite

Expression of Toll-like receptors in human endometrial epithelial cells and cell lines.

Journal Article Am J Reprod Immunol · July 2004 PROBLEM: Are toll-like receptors (TLRs) expressed by human endometrium and endometrial cell lines? METHODS OF STUDY: Expression of each TLR mRNA species was determined by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of proliferative-ph ... Full text Link to item Cite

Potential nonhormonal therapeutics for medical treatment of leiomyomas.

Journal Article Semin Reprod Med · May 2004 Uterine leiomyomas are a common disorder resulting in significant morbidity for women and substantial economic impact on the health care system. Current therapies include conservative surgery, hysterectomy, and hormonal therapy. Conservative surgical thera ... Full text Link to item Cite

Understanding endometriosis is the key to successful therapeutic management.

Journal Article Fertil Steril · May 2004 Understanding endometriosis on a molecular, biochemical, and genetic level will lead to better methods for the diagnosis and therapeutic management of this enigmatic disease. ... Full text Link to item Cite

Epithelial invasion by Escherichia coli bearing Dr fimbriae is controlled by nitric oxide-regulated expression of CD55.

Journal Article Infect Immun · May 2004 We previously reported that inhibition of nitric oxide (NO) increases the rate of bacteremia and maternal mortality in pregnant rats with uterine infection by Escherichia coli expressing the Dr fimbria (Dr(+)). Epithelial binding and invasion by Dr(+) E. c ... Full text Link to item Cite

Human endometrial TLR3 expression is cycle-dependent and localized to the epithelium.

Conference JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION · 2004 Cite

Efficacy of second versus third generation oral contraceptives in the treatment of hirsutism.

Journal Article Contraception · May 2003 OBJECTIVE: To compare second versus third generation combination oral contraceptives (OCs) in the treatment of hirsutism. METHODS: Women with hirsutism, as defined by a minimum Ferriman-Gallwey score of 10, were randomized in a double-blind fashion to rece ... Full text Link to item Cite

Regulated expression of heparin-binding EGF-like growth factor (HB-EGF) in the human endometrium: a potential paracrine role during implantation.

Journal Article Mol Reprod Dev · August 2002 Heparin-binding epidermal growth factor (HB-EGF) is a recently identified member of the EGF growth factor family found to be expressed in the uterus of both mouse and human at the time of implantation. In the present study, we investigated the expression p ... Full text Link to item Cite

In vivo and in vitro evidence suggest that HB-EGF regulates endometrial expression of human decay-accelerating factor.

Journal Article J Clin Endocrinol Metab · March 2002 Human endometrium expresses the critical complement component C3 in a cyclic fashion, with the highest expression in the secretory phase. As activated complement can kill cells, self or foreign, the secretory endometrial epithelium protects itself by conco ... Full text Link to item Cite

Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells.

Journal Article Mol Endocrinol · March 2002 Estrogen and progesterone regulate HOXA10 expression in the endometrium, where HOXA10 is necessary for implantation. The integrins are also involved in early embryo-endometrial interactions. Here we show that HOXA10 directly regulates beta3-integrin subuni ... Full text Link to item Cite

Serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate therapy in anovulatory infertile women.

Journal Article Fertil Steril · April 1999 OBJECTIVE: To determine the serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate treatment in anovulatory infertile women. DESIGN: Prospective cohort. SETTING: Tertiary institutional infertility clinic. PATI ... Full text Link to item Cite

Instilled SP-A is not recycled by rat lung Clara Cells.

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 1999 Cite

Integrins and other cell adhesion molecules in endometrium and endometriosis.

Journal Article Semin Reprod Endocrinol · 1997 Endometriosis is a disease that affects about 5% of women of reproductive age, but is found much more frequently in those with pelvic pain and/or infertility. In affected individuals, shed endometrium is thought to attach and spread within the pelvis throu ... Full text Link to item Cite

PULMONARY SURFACTANT - BASIC BIOLOGY AND CLINICAL USE - PREFACE

Journal Article SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE · 1995 Cite

SURFACTANT TREATMENT OF PRIMATE LUNG OXYGEN-TOXICITY

Conference LUNG SURFACTANT: BASIC RESEARCH IN THE PATHOGENESIS OF LUNG DISORDERS · January 1, 1994 Link to item Cite

A nonradioactive assay for transfected chloramphenicol acetyltransferase activity using fluorescent substrates.

Journal Article Anal Biochem · September 2, 1991 Studies of the transcriptional activity of gene promoters have been greatly assisted by the widespread use of the chloramphenicol acetyltransferase (CAT) gene as a reporter gene. Previous techniques for assaying CAT enzymatic activity have utilized radioac ... Full text Link to item Cite

Specific inhibition of protein kinase A in granulosa cells abolishes gonadotropin regulation of the proopiomelanocortin promoter.

Journal Article J Biol Chem · August 25, 1991 Gonadotropins (follicle-stimulating hormone (FSH), luteinizing hormone, and human chorionic gonadotropin) and beta-adrenergic agonists have been shown to stimulate expression of the proopiomelanocortin (POMC) gene in ovarian granulosa cells. The current st ... Link to item Cite

Intracellular mechanisms of gonadotropin-stimulated gene expression in granulosa cells.

Journal Article Steroids · May 1991 Previous studies have shown that the gonadotropins follicle-stimulating hormone and luteinizing hormone stimulate proopiomelanocortin (POMC) promoter activity and mRNA levels in ovarian granulosa cells. The objective of these studies was to determine the r ... Full text Link to item Cite

The regulation of proenkephalin expression in a distinct population of glial cells.

Journal Article EMBO J · March 1990 The expression of opioid genes was examined in isolated populations of glial cells in primary culture. Northern blot analysis of purified type I astrocytes, oligodendrocytes and mixed oligodendrocyte-type-2-astrocyte lineage cells derived from cerebral cor ... Full text Link to item Cite

THE ALVEOLAR EPITHELIUM - INVIVO COMPOSITION, DIFFERENTIATION, AND RESPONSE TO HORMONES

Conference BIOLOGY, TOXICOLOGY, AND CARCINOGENESIS OF RESPIRATORY EPITHELIUM · 1990 Cite

Androgens amplify beta-adrenergic and FSH stimulation of granulosa cells.

Journal Article Steroids · December 1989 The effects of androgens on granulosa cell stimulation by isoproterenol and follicle-stimulating hormone (FSH) were determined. Two functional parameters of granulosa cell stimulation were monitored: (a) activity of a transfected proopiomelanocortin (POMC) ... Full text Link to item Cite

Gonadotropin regulation of the rat proopiomelanocortin promoter: characterization by transfection of primary ovarian granulosa cells.

Journal Article Mol Endocrinol · January 1989 To characterize the transcriptional effects of human (h)FSH and hCG on the POMC gene, primary rat granulosa cells were transiently transfected with a chloramphenicol acetyltransferase (CAT) reporter plasmid under the control of the POMC promoter and 5' reg ... Full text Link to item Cite

The regulation of granulosa cell proopiomelanocortin messenger ribonucleic acid by androgens and gonadotropins.

Journal Article Endocrinology · November 1986 We have previously demonstrated the presence of proopiomelanocortin (POMC) messenger RNA (mRNA) in rat granulosa cells. This study examines the unique, tissue-specific regulation of granulosa cell POMC mRNA levels by hormones with established regulatory ef ... Full text Link to item Cite

Detection of chloramphenicol acetyl transferase activity in transfected cells: a rapid and sensitive HPLC-based method.

Journal Article DNA · December 1985 An assay based on high-performance liquid chromatography (HPLC) has been developed for determining the expression of the acetyl coenzyme A: chloramphenicol 3-O-acetyltransferase gene in transfected cells. The assay is based on the separation of extracted, ... Full text Link to item Cite