Scholars@Duke
Thomas Anthony D'Amico

Thomas Anthony D'Amico

Gary Hock Distinguished Professor of Surgery
Surgery, Cardiovascular and Thoracic Surgery
thomas.damico@duke.edu
Box 3496 Med Ctr, Durham, NC 27710
Duke South - 3589 White Zone, Durham, NC 27710

Selected Publications

The Role of Sleep Apnea in Postoperative Neurocognitive Disorders Among Older Noncardiac Surgery Patients: A Prospective Cohort Study.

Journal Article Anesth Analg · January 1, 2025 BACKGROUND: Obstructive sleep apnea is associated with increased dementia risk, yet its role in postoperative neurocognitive disorders is unclear. Here, we studied whether the severity of untreated obstructive sleep apnea is associated with the severity of ... Full text Link to item Cite

Roles, Responsibilities, and Expectations of Medical Students on Surgical Subinternships: A Modified Delphi Consensus Study.

Journal Article Acad Med · August 1, 2024 PURPOSE: Surgical subinternships are important rotations for students preparing for a career in general surgery; however, these rotations often vary by institution and service. This modified Delphi study was conducted to reach a consensus set of roles, res ... Full text Link to item Cite

Impact of lymphadenectomy extent on immunotherapy efficacy in postresectional recurred non-small cell lung cancer: a multi-institutional retrospective cohort study.

Journal Article Int J Surg · January 1, 2024 BACKGROUND: Lymph node (LN) dissection is a common procedure for non-small cell lung cancer (NSCLC) to ascertain disease severity and treatment options. However, murine studies have indicated that excising tumor-draining LNs diminished immunotherapy effect ... Full text Link to item Cite

The American Association for Thoracic Surgery (AATS) 2023 Expert Consensus Document: Staging and multidisciplinary management of patients with early-stage non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · September 2023 Novel targeted therapy and immunotherapy drugs have recently been approved for use in patients with surgically resectable lung cancer. Accurate staging, early molecular testing, and knowledge of recent trials are critical to optimize oncologic outcomes in ... Full text Link to item Cite

The Effect of Center Esophagectomy Volume on Outcomes in Clinical Stage I to III Esophageal Cancer.

Journal Article Ann Surg · July 1, 2023 OBJECTIVE: To determine the threshold annualized esophagectomy volume that is associated with improved survival, oncologic resection, and postoperative outcomes. BACKGROUND: Esophagectomy at high-volume centers is associated with improved outcomes; however ... Full text Link to item Cite

China's Opaque Wall of Secrecy.

Journal Article Ann Thorac Surg · April 2023 Full text Link to item Cite

Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · April 2023 Cancers originating in the esophagus or esophagogastric junction constitute a major global health problem. Esophageal cancers are histologically classified as squamous cell carcinoma (SCC) or adenocarcinoma, which differ in their etiology, pathology, tumor ... Full text Link to item Cite

The Impact of Adjuvant Hemithoracic Radiation on Outcomes in Patients With Stage I-III Malignant Pleural Mesothelioma: A Dual Registry Analysis.

Journal Article Ann Surg · March 1, 2023 BACKGROUND: The outcomes associated with receipt of adjuvant radiation in patients after surgery for MPM are poorly understood. OBJECTIVE: The objective of this study was to use 2 registries to compare the outcomes of patients receiving adjuvant radiation ... Full text Link to item Cite

Japanese Oncology Group 0802: Another giant leap.

Journal Article J Thorac Cardiovasc Surg · March 2023 Full text Link to item Cite

Multi-institutional Care in Clinical Stage II and III Esophageal Cancer.

Journal Article Ann Thorac Surg · February 2023 BACKGROUND: Management of clinical stage II or III esophageal cancer requires multidisciplinary care. Multi-institutional care has been associated with worse survival in other malignant diseases. This study aimed to determine the impact of multi-institutio ... Full text Link to item Cite

Utilization Trends and Volume-outcomes Relationship of Endoscopic Resection for Early Stage Esophageal Cancer.

Conference Ann Surg · January 1, 2023 OBJECTIVES: We describe utilization trends and center volume-outcomes relationship of ER of early stage esophageal cancer using a large hospitalbased registry. SUMMARY OF BACKGROUND DATA: ER is increasingly accepted as the preferred treatment for early sta ... Full text Link to item Cite

Tumor Size, Histology, and Survival After Stereotactic Ablative Radiotherapy and Sublobar Resection in Node-negative Non-small Cell Lung Cancer.

Journal Article Ann Surg · December 1, 2022 BACKGROUND: Although SABR is increasingly emerging as an alternative to surgery for node-negative non-small cell lung cancer, there is poor understanding of patients who may most benefit SABR compared to surgery. OBJECTIVE: This study examined the relation ... Full text Link to item Cite

Video-Assisted Thoracic Surgery Technique for Chest Wall Resection

Journal Article Operative Techniques in Thoracic and Cardiovascular Surgery · September 1, 2022 Chest wall resection is indicated in the management of operable primary chest wall tumors and lung cancers with chest wall invasion in carefully selected patients. Traditionally, chest wall resection has been performed via open thoracotomy, which is associ ... Full text Cite

Perioperative Outcomes and Survival After Preoperative Immunotherapy for Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · June 2022 BACKGROUND: Although preoperative immunotherapy is increasingly utilized for non-small cell lung cancer, there remains a paucity of robust clinical data on its safety and long-term survival. Our objective was to evaluate the perioperative outcomes and surv ... Full text Link to item Cite

The Impact of Extended Delayed Surgery for Indolent Lung Cancer or Part-Solid Ground Glass Nodules.

Journal Article Ann Thorac Surg · June 2022 BACKGROUND: During the COVID-19 pandemic, patients with lung cancer may experience treatment delays. The objective of this study was to evaluate the impact of extended treatment delays on survival among patients with stage I typical bronchopulmonary carcin ... Full text Link to item Cite

Non-Small Cell Lung Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · May 2022 NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Non-Small Cell Lung Cancer (NSCLC) provide recommended management for patients with NSCLC, including diagnosis, primary treatment, surveillance for relapse, and subsequent treatment. Patie ... Full text Link to item Cite

The Relationship Between Lymph Node Ratio and Survival Benefit With Adjuvant Chemotherapy in Node-positive Esophageal Adenocarcinoma.

Journal Article Ann Surg · March 1, 2022 BACKGROUND: We hypothesized that the ratio of positive lymph nodes to total assessed lymph nodes (LNR) is an indicator of cancer burden in esophageal adenocarcinoma and may identify patients who may most benefit from AC. OBJECTIVE: The aim of this study wa ... Full text Link to item Cite

Impact of Time to Endoscopic Resection on Outcomes for Stage I Esophageal Adenocarcinoma.

Journal Article Ann Thorac Surg · March 2022 BACKGROUND: Endoscopic resection (ER) is the preferred treatment for superficial esophageal cancer; however, a safe time frame for performing ER has not been established. This study evaluated the period in which ER can be performed for patients with stage ... Full text Link to item Cite

Radical Minimally Invasive Surgery After Immuno-chemotherapy in Initially-unresectable Stage IIIB Non-small cell Lung Cancer.

Journal Article Ann Surg · March 1, 2022 INTRODUCTION: Use of neoadjuvant immunotherapy agent in advanced stage NSCLC is controversial. Herein, we aim to report on a case series of successful conversion from initial unresectable stage cIIIB NSCLC to radical minimally invasive surgery through immu ... Full text Link to item Cite

The Impact of Adjuvant Therapy on Survival After Esophagectomy for Node-negative Esophageal Adenocarcinoma.

Journal Article Ann Surg · February 1, 2022 OBJECTIVE: Determine whether adjuvant chemotherapy is associated with a survival benefit in high risk T2-4a, pathologically node-negative distal esophageal adenocarcinoma. SUMMARY OF BACKGROUND DATA: There is minimal literature to substantiate the NCCN gui ... Full text Link to item Cite

Perioperative outcomes of pulmonary resection after neoadjuvant pembrolizumab in patients with non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · February 2022 OBJECTIVES: Pembrolizumab is a programmed death receptor-1 masking antibody approved for metastatic non-small cell lung cancer. This Phase 2 study (NCT02818920) of neoadjuvant pembrolizumab in non-small cell lung cancer had a primary end point of safety an ... Full text Link to item Cite

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

Journal Article Ann Clin Transl Neurol · February 2022 OBJECTIVE: Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cereb ... Full text Open Access Link to item Cite

Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · February 2022 Gastric cancer is the third leading cause of cancer-related deaths worldwide. Over 95% of gastric cancers are adenocarcinomas, which are typically classified based on anatomic location and histologic type. Gastric cancer generally carries a poor prognosis ... Full text Link to item Cite

REPLY FROM AUTHORS: THE BOAT, THE SWORD, AND THE OPACITY OF CHINESE TRANSPLANT DATA

Journal Article JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY · 2022 Cite

Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.

Journal Article Br J Anaesth · December 2021 BACKGROUND: Cognitive dysfunction after surgery is a major issue in older adults. Here, we determined the effect of APOE4 on perioperative neurocognitive function in older patients. METHODS: We enrolled 140 English-speaking patients ≥60 yr old scheduled fo ... Full text Open Access Link to item Cite

Small Cell Lung Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · December 2021 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Small Cell Lung Cancer (SCLC) provide recommended management for patients with SCLC, including diagnosis, primary treatment, surveillance for relapse, and subsequent treatment. This se ... Full text Link to item Cite

Commentary: Inside out.

Journal Article JTCVS Open · September 2021 Full text Link to item Cite

A National Analysis of Minimally Invasive Vs Open Segmentectomy for Stage IA Non-Small-Cell Lung Cancer.

Journal Article Seminars in thoracic and cardiovascular surgery · June 2021 The objective of this study was to compare long-term outcomes of open vs minimally invasive (MIS) segmentectomy for early stage non-small-cell lung cancer (NSCLC), which has not been previouslyevaluated using national studies. Outcomes of open vs MIS segme ... Full text Cite

Estimating the Impact of Extended Delay to Surgery for Stage I Non-small-cell Lung Cancer on Survival.

Journal Article Ann Surg · May 1, 2021 OBJECTIVE: The purpose of this study is to evaluate the impact of extended delay to surgery for stage I NSCLC. SUMMARY OF BACKGROUND DATA: During the COVID-19 pandemic, patients with NSCLC may experience delays in care, and some national guidelines recomme ... Full text Link to item Cite

The effect of extent of resection on outcomes in patients with limited stage small cell lung cancer.

Conference J Thorac Cardiovasc Surg · April 2021 BACKGROUND: There is poor understanding of the comparative effectiveness of lobar and sublobar resections for limited-stage small cell lung cancer (SCLC). We analyzed the National Cancer Database to examine the outcomes of patients undergoing wedge resecti ... Full text Link to item Cite

NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 2.2021.

Journal Article J Natl Compr Canc Netw · March 2, 2021 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Non-Small Cell Lung Cancer (NSCLC) address all aspects of management for NSCLC. These NCCN Guidelines Insights focus on recent updates to the NCCN Guidelines regarding targeted therapi ... Full text Link to item Cite

A National Analysis of Short-term Outcomes and Long-term Survival Following Thoracoscopic Versus Open Lobectomy for Clinical Stage II Non-Small-Cell Lung Cancer.

Journal Article Ann Surg · March 1, 2021 OBJECTIVE: To compare outcomes after open versus thoracoscopic (VATS) lobectomy for clinical stage II (cN1) non-small-cell lung cancer (NSCLC). BACKGROUND: There have been no published studies evaluating the impact of a VATS approach to lobectomy for N1 NS ... Full text Link to item Cite

Impact of Age on Surgical Outcomes for Locally Advanced Esophageal Cancer.

Journal Article Ann Thorac Surg · March 2021 BACKGROUND: Older patients are often considered high-risk surgical candidates for locally advanced esophageal cancer, and the benefit of surgery in this population is unclear. This national analysis examines the effect of age on esophagectomy outcomes and ... Full text Link to item Cite

Discussion.

Journal Article J Thorac Cardiovasc Surg · March 2021 Full text Link to item Cite

Patterns of Use of Induction Therapy for T2N0 Esophageal Cancer.

Journal Article Ann Thorac Surg · February 2021 BACKGROUND: Induction therapy for patients with cT2N0M0 esophageal cancer is controversial. We performed a retrospective cohort analysis of the National Cancer Database to examine the patterns of use of induction therapy for this population. METHODS: The N ... Full text Link to item Cite

The Effect of Tumor Size and Histologic Findings on Outcomes After Segmentectomy vs Lobectomy for Clinically Node-Negative Non-Small Cell Lung Cancer.

Journal Article Chest · January 2021 BACKGROUND: The interaction between tumor size and the comparative prognosis of lobar and sublobar resection has been defined poorly. RESEARCH QUESTION: The purpose of this study was to characterize the relationship between tumor size and the receipt of se ... Full text Link to item Cite

Response.

Journal Article Chest · January 2021 Full text Link to item Cite

National Comprehensive Cancer Network Guidelines: Who Makes Them? What Are They? Why Are They Important?

Journal Article The Annals of thoracic surgery · December 2020 The National Comprehensive Cancer Network (NCCN) is a not-for-profit alliance of 28 leading cancer centers dedicated to improving and facilitating quality, effective, efficient, and accessible cancer care so that patients can live better lives. The NCCN of ... Full text Cite

Effect of Lymph Node Assessment on Outcomes in Surgery for Limited Stage Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · December 2020 BACKGROUND: The National Comprehensive Cancer Network guidelines recommend surgery for limited stage small cell lung cancer (SCLC). However, there is no literature on minimum acceptable lymph node retrieval in surgery for SCLC. METHODS: The National Cancer ... Full text Link to item Cite

Patterns of Care in Neoadjuvant Chemoradiotherapy for Node-Positive Esophageal Adenocarcinoma.

Journal Article Ann Thorac Surg · December 2020 BACKGROUND: The aims of this study were to examine the factors associated with use of neoadjuvant chemoradiotherapy (NCR) for patients with locally advanced esophageal cancer and to evaluate the effect of NCR on survival. METHODS: The 2004 to 2015 National ... Full text Link to item Cite

Stereotactic Body Radiotherapy Versus Delayed Surgery for Early-stage Non-small-cell Lung Cancer.

Journal Article Ann Surg · December 2020 OBJECTIVE: To evaluate the overall survival of patients with operable stage IA non-small-cell lung cancer (NSCLC) who undergo "early" SBRT (within 0-30 days after diagnosis) versus "delayed" surgery (90-120 days after diagnosis). SUMMARY OF BACKGROUND DATA ... Full text Link to item Cite

The Role of Neoadjuvant Chemotherapy in Patients With Resectable Malignant Pleural Mesothelioma-An Institutional and National Analysis.

Journal Article J Natl Cancer Inst · November 1, 2020 BACKGROUND: There is no standard of care with respect to the use of neoadjuvant chemotherapy (NAC) in resectable malignant pleural mesothelioma (MPM). We performed an intention-to-treat analysis with data from a single institution and the National Cancer D ... Full text Link to item Cite

Resection of the irradiated esophagus: the impact of lymph node yield on survival.

Journal Article Dis Esophagus · October 12, 2020 There is debate surrounding the appropriate threshold for lymph node harvest during esophagectomy in patients with esophageal cancer, specifically for those receiving preoperative radiation. The purpose of this study was to determine the impact of lymph no ... Full text Link to item Cite

Commentary: Scientists still behaving badly.

Journal Article J Thorac Cardiovasc Surg · September 2020 Full text Link to item Cite

The Effect of Timing of Adjuvant Therapy on Survival After Esophagectomy.

Journal Article Ann Thorac Surg · September 2020 BACKGROUND: Adjuvant chemotherapy (AC) after esophagectomy improves survival in esophageal cancer when induction therapy is not given; however, the optimal timing for initiation of AC is poorly characterized. We aimed to determine the impact of timing of A ... Full text Link to item Cite

Impact of Surveillance After Lobectomy for Lung Cancer on Disease Detection and Survival.

Journal Article Clin Lung Cancer · September 2020 INTRODUCTION: Existing guidelines for surveillance after non-small-cell lung cancer (NSCLC) treatment are inconsistent and have relatively sparse supporting literature. This study characterizes detection rates of metachronous and recurrent disease during s ... Full text Link to item Cite

A national analysis of open versus minimally invasive thymectomy for stage I to III thymoma.

Journal Article J Thorac Cardiovasc Surg · August 2020 OBJECTIVE: The oncologic efficacy of minimally invasive thymectomy for thymoma is not well characterized. We compared short-term outcomes and overall survival between open and minimally invasive (video-assisted thoracoscopic and robotic) approaches using t ... Full text Link to item Cite

Cardiothoracic surgeons in pandemics: Ethical considerations.

Journal Article J Thorac Cardiovasc Surg · August 2020 Full text Link to item Cite

Disparities in guideline-concordant treatment for node-positive, non-small cell lung cancer following surgery.

Conference J Thorac Cardiovasc Surg · July 2020 OBJECTIVES: To examine guideline concordance across a national sample and determine the relationship between socioeconomic factors, use of recommended postoperative adjuvant therapy, and outcomes for patients with resected pN1 or pN2 non-small cell lung ca ... Full text Link to item Cite

The effect of age on survival after endoscopic resection versus surgery for T1a esophageal cancer.

Conference J Thorac Cardiovasc Surg · July 2020 BACKGROUND: Endoscopic resection has emerged as a treatment option for T1a esophageal cancer, but the impact of age on patient selection for surgery versus endoscopic resection has not been well studied. We hypothesized that endoscopic resection would be a ... Full text Link to item Cite

Commentary: Are we home yet?

Journal Article J Thorac Cardiovasc Surg · July 2020 Full text Link to item Cite

Discussion.

Journal Article J Thorac Cardiovasc Surg · July 2020 Full text Link to item Cite

Commentary: Trust but verify-How do we keep the faith?

Journal Article J Thorac Cardiovasc Surg · June 2020 Full text Link to item Cite

The influence of adjuvant therapy on survival in patients with indeterminate margins following surgery for non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · May 2020 BACKGROUND: The significance of indeterminate margins following surgery for non-small cell lung cancer (NSCLC) is unknown. We evaluated the influence of adjuvant therapy on survival in patients whose cancer showed indeterminate margins. METHODS: Patients w ... Full text Link to item Cite

A Minimally Invasive Approach to Lobectomy After Induction Therapy Does Not Compromise Survival.

Journal Article Ann Thorac Surg · May 2020 BACKGROUND: The objective of this study was to evaluate the impact of a video-assisted thoracoscopic (VATS) approach on outcomes in patients who underwent lobectomy after induction therapy. METHODS: Outcomes of patients with T2-T4, N0, M0 and T1-T4, N1-N2, ... Full text Link to item Cite

The Role of Adjuvant Therapy in Patients With Margin-Positive (R1) Esophagectomy: A National Analysis.

Journal Article J Surg Res · May 2020 BACKGROUND: We performed a nationwide analysis to assess the impact of adjuvant therapy on survival after a microscopically margin-positive (R1) resection for esophageal cancer. METHODS: The National Cancer Database was used to identify patients with R1 re ... Full text Link to item Cite

Impact of Positive Margins and Radiation After Tracheal Adenoid Cystic Carcinoma Resection on Survival.

Journal Article Ann Thorac Surg · April 2020 BACKGROUND: Achieving negative margins for adenoid cystic carcinoma (ACC) of the trachea can be technically difficult. This study evaluated the impact of positive margins on prognosis and tested the hypothesis that radiation improves survival in the settin ... Full text Link to item Cite

Effect of time to surgery on outcomes in stage I esophageal adenocarcinoma.

Journal Article J Thorac Cardiovasc Surg · April 2020 BACKGROUND: There are limited data on the safe interval from diagnosis to surgery in patients with stage I esophageal adenocarcinoma. We hypothesized that increased time to surgery would be associated with worse survival and increased nodal upstaging. METH ... Full text Link to item Cite

The immunotherapeutic landscape in non-small cell lung cancer and its surgical horizons.

Journal Article J Thorac Cardiovasc Surg · April 2020 Lung cancer continues to be a leading cause of cancer-related death worldwide. Despite tremendous advances in surgical technique, chemotherapy regimens, radiation, and targeted therapies, survival is <50% at 5 years. Immunotherapy, specifically immune chec ... Full text Link to item Cite

Commentary: Seeking the grail? Choose wisely.

Journal Article J Thorac Cardiovasc Surg · March 2020 Full text Link to item Cite

Quality Measurement in Cancer Care: A Review and Endorsement of High-Impact Measures and Concepts.

Journal Article J Natl Compr Canc Netw · March 2020 Although oncology care has evolved, outcome assessment remains a key challenge. Outcome measurement requires identification and adoption of a succinct list of metrics indicative of high-quality cancer care for use within and across healthcare systems. NCCN ... Full text Link to item Cite

The Oldest Old: A National Analysis of Outcomes for Patients 90 Years or Older With Lung Cancer.

Journal Article Ann Thorac Surg · February 2020 BACKGROUND: Most clinicians will encounter patients 90 years or older with non-small cell lung cancer (NSCLC), but evidence that informs treatment decisions for this extremely elderly population is lacking. This study evaluated outcomes associated with tre ... Full text Link to item Cite

Surgery Is Associated With Survival Benefit in T4a Esophageal Adenocarcinoma: A National Analysis.

Journal Article Ann Thorac Surg · December 2019 BACKGROUND: The National Comprehensive Cancer Network guidelines recommend consideration of surgery for clinical T4a esophageal adenocarcinoma. There are limited data on the outcomes of patients with T4a adenocarcinoma treated with surgery vs definitive ch ... Full text Link to item Cite

Outcomes for Surgery in Large Cell Lung Neuroendocrine Cancer.

Journal Article J Thorac Oncol · December 2019 INTRODUCTION: There are limited small, single-institution observational studies examining the role of surgery in large cell neuroendocrine cancer (LCNEC). We investigated the outcomes of surgery for stage I to IIIA LCNEC by using the National Cancer Databa ... Full text Link to item Cite

Outcomes of surgery versus chemoradiotherapy in patients with clinical or pathologic stage N3 non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · December 2019 BACKGROUND: Because surgery is rarely recommended, there is minimal literature comparing the outcomes of surgery and chemoradiation in stage N3 non-small cell lung cancer (NSCLC). We examined the outcomes of definitive chemoradiation versus multimodality t ... Full text Link to item Cite

NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 1.2020.

Journal Article J Natl Compr Canc Netw · December 2019 The NCCN Guidelines for Non-Small Cell Lung Cancer (NSCLC) address all aspects of management for NSCLC. These NCCN Guidelines Insights focus on recent updates in immunotherapy. For the 2020 update, all of the systemic therapy regimens have been categorized ... Full text Link to item Cite

Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.

Journal Article Anesth Analg · November 2019 Animal models suggest postoperative cognitive dysfunction may be caused by brain monocyte influx. To study this in humans, we developed a flow cytometry panel to profile cerebrospinal fluid (CSF) samples collected before and after major noncardiac surgery ... Full text Open Access Link to item Cite

Adjuvant Therapy for Patients With Early Large Cell Lung Neuroendocrine Cancer: A National Analysis.

Journal Article Ann Thorac Surg · August 2019 BACKGROUND: Current guidelines do not routinely recommend adjuvant therapy for resected stage I large cell lung neuroendocrine cancer (LCNEC). However, data regarding the role of adjuvant therapy in early LCNEC are limited. This National Cancer Database (N ... Full text Link to item Cite

Challenging 30-day mortality as a site-specific quality metric in non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · August 2019 OBJECTIVE: The objective of this project was to assess the best measure for postoperative outcomes by comparing 30-day and 90-day mortality rates after surgery for non-small cell lung cancer using the National Cancer Database. Secondarily, hospital perform ... Full text Link to item Cite

The role of thoracoscopic pneumonectomy in the management of non-small cell lung cancer: A multicenter study.

Journal Article J Thorac Cardiovasc Surg · July 2019 OBJECTIVE: The objective of this study was to evaluate the impact of the video-assisted thoracoscopic (VATS) approach on the outcomes of patients who underwent pneumonectomy. METHODS: The effect of the surgical approach on perioperative complications and s ... Full text Link to item Cite

A Nomogram for Predicting Cancer-Specific Survival of TNM 8th Edition Stage I Non-small-cell Lung Cancer.

Journal Article Ann Surg Oncol · July 2019 BACKGROUND: Models for predicting the survival outcomes of stage I non-small-cell lung cancer (NSCLC) defined by the newly released 8th edition TNM staging system are scarce. This study aimed to develop a nomogram for predicting the cancer-specific surviva ... Full text Link to item Cite

Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · July 1, 2019 Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide. Squamous cell carcinoma is the most common histology in Eastern Europe and Asia, and adenocarcinoma is most common in North America and Western Europe. Surgery is a major comp ... Full text Link to item Cite

The Optimal Treatment for Stage IIIA-N2 Non-Small Cell Lung Cancer: A Network Meta-Analysis.

Journal Article Ann Thorac Surg · June 2019 BACKGROUND: The optimal treatment for stage IIIA-N2 non-small cell lung cancer (NSCLC) is controversial. We aimed to address this important issue through a Bayesian network meta-analysis. METHODS: We performed a search of electronic databases for randomize ... Full text Link to item Cite

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.

Journal Article Anesthesiology · June 2019 BACKGROUND: Cognitive decline after cardiac surgery occurs frequently and persists in a significant proportion of patients. Preclinical studies and human trials suggest that intravenous lidocaine may confer protection in the setting of neurologic injury. I ... Full text Open Access Link to item Cite

Right-Sided Versus Left-Sided Pneumonectomy After Induction Therapy for Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · April 2019 BACKGROUND: A right-sided pneumonectomy after induction therapy for non-small cell lung cancer (NSCLC) has been shown to be associated with significant perioperative risk. We examined the effect of laterality on long-term survival after induction therapy a ... Full text Link to item Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal Article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

Predictors of staging accuracy, pathologic nodal involvement, and overall survival for cT2N0 carcinoma of the esophagus.

Journal Article The Journal of thoracic and cardiovascular surgery · March 2019 ObjectiveClinical T2N0 esophageal carcinoma is a heterogenous disease frequently complicated by inaccurate staging. Incorrect staging may lead to suboptimal treatment for patients with unidentified local-regionally advanced disease. Therapeutic op ... Full text Cite

A National Analysis of Long-term Survival Following Thoracoscopic Versus Open Lobectomy for Stage I Non-small-cell Lung Cancer.

Journal Article Annals of surgery · January 2019 ObjectiveThe objective of this study was to compare the long-term survival of open versus thoracoscopic (VATS) lobectomy for early stage non-small-cell lung cancer (NSCLC).BackgroundData from national studies on long-term survival for VAT ... Full text Cite

Minimally Invasive Approaches Do Not Compromise Outcomes for Pneumonectomy: A Comparison Using the National Cancer Database.

Journal Article J Thorac Oncol · January 2019 INTRODUCTION: Minimally invasive approaches are increasingly being used for the conduct of complex surgical procedures. Whether the benefits of minimally invasive approaches compared to thoracotomy for sublobar and lobar lung resection for NSCLC are realiz ... Full text Link to item Cite

Long-term Survival After Surgery Compared With Concurrent Chemoradiation for Node-negative Small Cell Lung Cancer.

Journal Article Ann Surg · December 2018 OBJECTIVE: To determine whether surgery with adjuvant chemotherapy offers a survival advantage over concurrent chemoradiation for patients with cT1-2N0M0 small cell lung cancer (SCLC). BACKGROUND: Although surgery with adjuvant chemotherapy is the recommen ... Full text Link to item Cite

Higher Use of Surgery Confers Superior Survival in Stage I Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · November 2018 BACKGROUND: Lobar resection is the gold standard therapy for medically fit patients with stage I non-small cell lung cancer (NSCLC). However, considerable variability exists in the use of surgical therapy. This study tested the hypothesis that center-based ... Full text Link to item Cite

Stereotactic body radiation therapy versus sublobar resection for stage I NSCLC.

Journal Article Lung Cancer · November 2018 PURPOSE: To compare sublobar resection and stereotactic body radiation therapy (SBRT) in patients with stage I non-small cell lung cancer (NSCLC). METHODS: Patients undergoing sublobar resection or SBRT for stage I NSCLC from 2007 to 2014 at Duke Universit ... Full text Link to item Cite

Oncologic Equivalence of Minimally Invasive Lobectomy: The Scientific and Practical Arguments.

Journal Article Ann Thorac Surg · August 2018 BACKGROUND: Despite the slow adoption of minimally invasive lobectomy (MIL), it is now a preferred approach for early lung cancer. Nevertheless, ongoing concerns about MIL oncologic effectiveness has led to calls for prospective, randomized trials. METHODS ... Full text Link to item Cite

Learning curve for uniportal video-assisted thoracoscopic surgery lobectomy-results from 120 consecutive patients.

Journal Article J Thorac Dis · August 2018 BACKGROUND: Uniportal video-assisted thoracoscopic surgery (VATS) is considered a technically demanding procedure. The learning curve, which directly influences the adoption of uniportal VATS, has not been described. In this study, we aimed to describe the ... Full text Link to item Cite

NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 5.2018.

Journal Article J Natl Compr Canc Netw · July 2018 The NCCN Guidelines for Non-Small Cell Lung Cancer (NSCLC) address all aspects of management for NSCLC. These NCCN Guidelines Insights focus on recent updates to the targeted therapy and immunotherapy sections in the NCCN Guidelines. For the 2018 update, a ... Full text Link to item Cite

Milestones in thoracic surgery.

Journal Article J Thorac Cardiovasc Surg · June 2018 OBJECTIVE: To highlight some of the legendary figures in the medical field who have paved the path of thoracic surgery today. METHODS: We reviewed historical articles and landmark studies published in anesthesiology, pulmonology, and thoracic surgery, and ... Full text Link to item Cite

Less is sometimes less.

Journal Article J Thorac Cardiovasc Surg · June 2018 Full text Link to item Cite

18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.

Journal Article Anesthesiology · April 2018 BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patie ... Full text Link to item Cite

Surgical treatment for early stage non-small cell lung cancer.

Journal Article J Thorac Dis · April 2018 Surgery is the standard of care for early stage non-small cell lung cancer. There is significant debate about the type of operation most effective for lung cancer. Minimally invasive techniques like video-assisted (VATS) and robot-assisted thoracoscopic su ... Full text Link to item Cite

Video assisted thoracic surgery with chest wall resection

Journal Article Video-Assisted Thoracic Surgery · April 2018 Full text Cite

Undoing the gaps in quality, cost, and value.

Journal Article J Thorac Cardiovasc Surg · March 2018 Full text Link to item Cite

Survival after radiation for stage I and II non-small cell lung cancer with positive margins.

Journal Article J Surg Res · March 2018 BACKGROUND: There is limited data guiding treatment for positive margins following lobectomy for early-stage non-small cell lung cancer (NSCLC). Using data from the National Cancer Data Base, we sought to determine whether radiation therapy following lobec ... Full text Link to item Cite

Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · March 2018 BACKGROUND: The objective of this study was to evaluate the safety and feasibility of using neoadjuvant chemotherapy plus ipilimumab followed by surgery as a treatment strategy for stage II-IIIA non-small cell lung cancer. METHODS: From 2013 to 2017, posto ... Full text Link to item Cite

Long-term outcomes of surgical resection for stage IV non-small-cell lung cancer: A national analysis.

Journal Article Lung Cancer · January 2018 OBJECTIVE: Treatment guidelines recommend surgical resection in select cases of stage IV non-small-cell lung cancer (NSCLC) but are based on limited evidence. This study evaluated outcomes associated with surgery in stage IV disease. METHODS: Factors assoc ... Full text Link to item Cite

Esophageal cancer in elderly patients: a population-based study.

Journal Article J Thorac Dis · January 2018 BACKGROUND: As the aging issue and increased elderly esophageal cancer (EC) patients, we sought to study the clinical characteristics, treatment modality and outcomes of EC patients 70 years or older compared with those younger than 70 years old. METHODS: ... Full text Link to item Cite

Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab.

Journal Article Clin Cancer Res · December 15, 2017 Purpose: To determine the immunologic effects of neoadjuvant chemotherapy plus ipilimumab in early-stage non-small cell lung cancer (NSCLC) patients.Experimental Design: This is a single-arm chemotherapy plus phased ipilimumab phase II study of 24 treatmen ... Full text Link to item Cite

Impact of Timing of Lobectomy on Survival for Clinical Stage IA Lung Squamous Cell Carcinoma.

Journal Article Chest · December 2017 BackgroundBecause the relationship between the timing of surgery following diagnosis of lung cancer and survival has not been precisely described, guidelines on what constitutes a clinically meaningful delay of resection of early-stage lung cancer ... Full text Cite

Patterns of Treatment and Outcomes for Definitive Therapy of Early Stage Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · December 2017 BACKGROUND: Definitive surgical and radiation therapy (RT) treatments are evolving rapidly for stage I non-small cell lung cancer (NSCLC). We hypothesized that utilization of definitive therapies increased between 2000 and 2010 and that survival improved f ... Full text Link to item Cite

Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.

Journal Article Anesth Analg · October 2017 BACKGROUND: Declining platelet counts may reveal platelet activation and aggregation in a postoperative prothrombotic state. Therefore, we hypothesized that nadir platelet counts after on-pump coronary artery bypass grafting (CABG) surgery are associated w ... Full text Open Access Link to item Cite

Adjuvant Chemotherapy Does Not Confer Superior Survival in Patients With Atypical Carcinoid Tumors.

Journal Article Ann Thorac Surg · October 2017 BACKGROUND: Although the use of adjuvant chemotherapy in patients with pathologically node-positive (pN+) atypical carcinoid tumor of the lung is an accepted practice, controversy exists about its use in pathologically node-negative (pN0) patients. Our aim ... Full text Link to item Cite

Design of interventional studies in thoracic surgery.

Journal Article J Thorac Dis · October 2017 Interventional studies differ from observational studies in that one or more specific interventions are evaluated. Randomized controlled trials remain the gold standard for interventional studies and can take different forms. In surgical studies, the three ... Full text Link to item Cite

Surgical resection after neoadjuvant chemoradiation for oesophageal adenocarcinoma: what is the optimal timing?

Journal Article Eur J Cardiothorac Surg · September 1, 2017 OBJECTIVES: The purpose of this study was to determine the optimal timing of surgical resection of oesophageal adenocarcinoma following neoadjuvant chemoradiotherapy (nCRT). METHODS: nCRT before resection of oesophageal adenocarcinoma yields improved overa ... Full text Link to item Cite

Induction chemotherapy for T3N0M0 non-small-cell lung cancer increases the rate of complete resection but does not confer improved survival.

Journal Article Eur J Cardiothorac Surg · August 1, 2017 OBJECTIVES: The objective of this study was to evaluate outcomes of induction therapy prior to an operation in patients with cT3 non-small-cell lung cancer (NSCLC). METHODS: Patients diagnosed with cT3N0M0 NSCLC from 2006 to 2011 in the National Cancer Dat ... Full text Link to item Cite

Get it right the first time.

Journal Article J Thorac Cardiovasc Surg · August 2017 Full text Link to item Cite

A national analysis of wedge resection versus stereotactic body radiation therapy for stage IA non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · August 2017 OBJECTIVE: Lobectomy is considered optimal therapy for early-stage non-small cell lung cancer, but sublobar wedge resection and stereotactic body radiation therapy are alternative treatments. This study compared outcomes between wedge resection and stereot ... Full text Link to item Cite

Patterns of Failure After Surgery for Non-Small-cell Lung Cancer Invading the Chest Wall.

Journal Article Clin Lung Cancer · July 2017 INTRODUCTION: The patterns of failure after resection of non-small-cell lung cancer (NSCLC) invading the chest wall are not well documented, and the role of adjuvant radiation therapy (RT) is unclear, prompting the present analysis. MATERIALS AND METHODS: ... Full text Link to item Cite

Keep moving forward.

Journal Article J Thorac Cardiovasc Surg · June 2017 Full text Link to item Cite

Surgery Versus Optimal Medical Management for N1 Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · June 2017 BACKGROUND: Adjuvant chemotherapy has been demonstrated to improve the outcomes of patients with N1 non-small cell lung cancer. It is unknown whether patients previously thought to have unresectable small cell lung cancer (SCLC) may have tumors amenable to ... Full text Link to item Cite

Impact of Examined Lymph Node Count on Precise Staging and Long-Term Survival of Resected Non-Small-Cell Lung Cancer: A Population Study of the US SEER Database and a Chinese Multi-Institutional Registry.

Journal Article J Clin Oncol · April 10, 2017 Purpose We investigated the correlation between the number of examined lymph nodes (ELNs) and correct staging and long-term survival in non-small-cell lung cancer (NSCLC) by using large databases and determined the minimal threshold for the ELN count. Meth ... Full text Link to item Cite

The Role of Extent of Surgical Resection and Lymph Node Assessment for Clinical Stage I Pulmonary Lepidic Adenocarcinoma: An Analysis of 1991 Patients.

Journal Article J Thorac Oncol · April 2017 BACKGROUND: This study examined the association of extent of lung resection, pathologic nodal evaluation, and survival for patients with clinical stage I (cT1-2N0M0) adenocarcinoma with lepidic histologic features in the National Cancer Data Base. METHODS: ... Full text Link to item Cite

Traveling to a High-volume Center is Associated With Improved Survival for Patients With Esophageal Cancer.

Journal Article Ann Surg · April 2017 BACKGROUND: An association between volume and outcomes has been observed for esophagectomy, though little is known about why or how patients choose low- or high-volume centers. The purpose of this study was to evaluate how travel burden and hospital volume ... Full text Link to item Cite

Non-Small Cell Lung Cancer, Version 5.2017, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · April 2017 This selection from the NCCN Guidelines for Non-Small Cell Lung Cancer (NSCLC) focuses on targeted therapies and immunotherapies for metastatic NSCLC, because therapeutic recommendations are rapidly changing for metastatic disease. For example, new recomme ... Full text Link to item Cite

Don't look back.

Journal Article J Thorac Cardiovasc Surg · March 2017 Full text Link to item Cite

Recommendations from the European Society of Thoracic Surgeons (ESTS) regarding computed tomography screening for lung cancer in Europe.

Journal Article Eur J Cardiothorac Surg · March 1, 2017 In order to provide recommendations regarding implementation of computed tomography (CT) screening in Europe the ESTS established a working group with eight experts in the field. On a background of the current situation regarding CT screening in Europe and ... Full text Link to item Cite

Immune profiling of circulating T cells and TILs following neoadjuvant ipilimumab and chemotherapy in non-small cell lung cancer (NSCLC).

Conference Journal of Clinical Oncology · March 1, 2017 26 Background: Ipilimumab (Ipi) is a humanized CTLA-4 antibody that blocks binding of CTLA-4 to B7, permitting T cell activation through CD28. Phased in Ipi added to chemotherapy (C) may enhance efficacy in NSCLC. Methods: Patien ... Full text Cite

Reply to D.A. Palma.

Journal Article J Clin Oncol · February 10, 2017 Full text Link to item Cite

Invited Commentary.

Journal Article Ann Thorac Surg · February 2017 Full text Link to item Cite

Reply to Perna et al.

Journal Article Eur J Cardiothorac Surg · February 1, 2017 Full text Link to item Cite

Reply to T.-H. Wang et al.

Journal Article J Clin Oncol · January 2017 Full text Link to item Cite

Anatomic thoracoscopic segmentectomy for early-stage lung cancer.

Journal Article J Vis Surg · 2017 Over the past 20 years, there have been significant advancements in thoracoscopic surgical techniques as well as in lung cancer screening protocols, which have identified greater numbers of smaller lung tumors (<2 cm) that are more frequently operable and ... Full text Link to item Cite

Uniportal lobectomy and segmentectomy-is it for all?

Journal Article J Vis Surg · 2017 Technological advances have markedly transformed the philosophy of thoracic surgery in the current era, with notable improvements in patient outcomes with video-assisted thoracoscopic surgery (VATS). More recently, innovations in uniportal VATS approaches ... Full text Link to item Cite

Thoracoscopic lobectomy after induction therapy-a paradigm shift?

Journal Article J Vis Surg · 2017 Video-assisted thoracoscopic approaches (or VATS) have gained significant momentum in the management of locally advanced NSCLC in the current era. Accrual of experiences and concurrent improvements in instrumentation and video technology have further enhan ... Full text Link to item Cite

A Risk Score to Assist Selecting Lobectomy Versus Sublobar Resection for Early Stage Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · December 2016 BACKGROUND: The long-term survival benefit of lobectomy over sublobar resection for early-stage non-small cell lung cancer must be weighed against a potentially increased risk of perioperative mortality. The objective of the current study was to create a r ... Full text Link to item Cite

Patient Preferences in Treatment Choices for Early-Stage Lung Cancer.

Journal Article Ann Thorac Surg · December 2016 BACKGROUND: Decision-making for lung cancer treatment can be complex because it involves both provider recommendations based on the patient's clinical condition and patient preferences. This study describes the relative importance of several considerations ... Full text Link to item Cite

Preface to the book This is life: the journey of uniportal VATS

Journal Article Video-Assisted Thoracic Surgery · November 2016 Full text Cite

Personalized and targeted therapy of esophageal squamous cell carcinoma: an update.

Journal Article Ann N Y Acad Sci · October 2016 Esophageal squamous cell carcinoma (ESCC) is a deadly disease that requires extensive research. In this review, we update recent progress in the research area of targeted therapy for ESCC. SOX2 and its associated proteins (e.g., ΔNP63α), which regulate lin ... Full text Link to item Cite

Gastric Cancer, Version 3.2016, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · October 2016 Gastric cancer is the fifth most frequently diagnosed cancer and the third leading cause of death from cancer in the world. Several advances have been made in the staging procedures, imaging techniques, and treatment approaches. The NCCN Clinical Practice ... Full text Link to item Cite

Outcomes of Major Lung Resection After Induction Therapy for Non-Small Cell Lung Cancer in Elderly Patients.

Journal Article Ann Thorac Surg · September 2016 BACKGROUND: This study analyzes the impact of age on perioperative outcomes and long-term survival of patients undergoing surgery after induction chemotherapy for non-small cell lung cancer. METHODS: Short- and long-term outcomes of patients with non-small ... Full text Link to item Cite

Impact of Age on Long-Term Outcomes of Surgery for Malignant Pleural Mesothelioma.

Journal Article Clin Lung Cancer · September 2016 BACKGROUND: Although malignant pleural mesothelioma (MPM) is generally a disease associated with more advanced age, the association of age, treatment, and outcomes has not been well-characterized. We evaluated the impact of age on outcomes in patients with ... Full text Link to item Cite

Induction Chemotherapy is Not Superior to a Surgery-First Strategy for Clinical N1 Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · September 2016 BACKGROUND: Guidelines recommend primary surgical resection for non-small cell lung cancer (NSCLC) patients with clinical N1 disease and adjuvant chemotherapy if nodal disease is confirmed after resection. We tested the hypothesis that induction chemothera ... Full text Link to item Cite

Reply to Perna et al.

Journal Article Eur J Cardiothorac Surg · August 29, 2016 Full text Link to item Cite

Multidisciplinary approach to treatment of radiation-induced chest wall sarcoma.

Journal Article Gen Thorac Cardiovasc Surg · August 2016 Radiation-induced sarcoma (RIS) is a rare complication following therapeutic external irradiation for lung cancer patients. Patients with RIS may develop recurrence or metastasis of the previous disease and also at high risk for early chest wall complicati ... Full text Link to item Cite

Minimally Invasive Versus Open Esophagectomy for Esophageal Cancer: A Population-Based Analysis.

Journal Article Ann Thorac Surg · August 2016 BACKGROUND: The objective of this study was to evaluate outcomes of minimally invasive approaches to esophagectomy using population-level data. METHODS: Multivariable regression modeling was used to determine predictors associated with the use of minimally ... Full text Link to item Cite

Thoracoscopic Lobectomy for Non-small Cell Lung Cancer.

Journal Article Surg Oncol Clin N Am · July 2016 Lobectomy is the gold standard treatment in operable patients with surgically resectable non-small cell lung cancer. Thoracoscopic lobectomy has emerged as an option for surgeons facile with the technique. Video-assisted thoracoscopic surgery (VATS) is use ... Full text Link to item Cite

NCCN Guidelines Insights: Malignant Pleural Mesothelioma, Version 3.2016.

Journal Article J Natl Compr Canc Netw · July 2016 These NCCN Guidelines Insights focus on recent updates to the NCCN Guidelines for Malignant Pleural Mesothelioma (MPM). These NCCN Guidelines Insights discuss systemic therapy regimens and surgical controversies for MPM. The NCCN panel recommends cisplatin ... Full text Link to item Cite

Comparative effectiveness of stereotactic radiosurgery versus whole-brain radiation therapy for patients with brain metastases from breast or non-small cell lung cancer.

Journal Article Cancer · July 1, 2016 BACKGROUND: The optimal treatment for patients with brain metastases remains controversial as the use of stereotactic radiosurgery (SRS) alone, replacing whole-brain radiation therapy (WBRT), has increased. This study determined the patterns of care at mul ... Full text Link to item Cite

Long-term survival following open versus thoracoscopic lobectomy after preoperative chemotherapy for non-small cell lung cancer.

Journal Article Eur J Cardiothorac Surg · June 2016 OBJECTIVES: Video-assisted thoracoscopic (VATS) lobectomy is increasingly accepted for the management of early-stage non-small cell lung cancer (NSCLC), but its role for locally advanced cancers has not been as well characterized. We compared outcomes of p ... Full text Link to item Cite

Impact of patient selection and treatment strategies on outcomes after lobectomy for biopsy-proven stage IIIA pN2 non-small cell lung cancer.

Journal Article Eur J Cardiothorac Surg · June 2016 OBJECTIVES: We evaluated the impact of patient selection and treatment strategies on long-term outcomes of patients who had lobectomy after induction therapy for stage IIIA pN2 non-small cell lung cancer (NSCLC). METHODS: The impact of various patient sele ... Full text Link to item Cite

Long-term outcomes after lobectomy for non-small cell lung cancer when unsuspected pN2 disease is found: A National Cancer Data Base analysis.

Journal Article J Thorac Cardiovasc Surg · May 2016 OBJECTIVE: There are few studies evaluating whether to proceed with planned resection when a patient with non-small cell lung cancer (NSCLC) unexpectedly is found to have N2 disease at the time of thoracoscopy or thoracotomy. To help guide management of th ... Full text Link to item Cite

Role of Adjuvant Therapy in a Population-Based Cohort of Patients With Early-Stage Small-Cell Lung Cancer.

Journal Article J Clin Oncol · April 1, 2016 PURPOSE: Data on optimal adjuvant therapy after complete resection of small-cell lung cancer (SCLC) are limited, and in particular, there have been no studies evaluating the role of adjuvant chemotherapy, with or without prophylactic cranial irradiation, r ... Full text Link to item Cite

Traveling to a High-volume Center is Associated With Improved Survival for Patients With Esophageal Cancer.

Journal Article Ann Surg · March 15, 2016 BACKGROUND: An association between volume and outcomes has been observed for esophagectomy, though little is known about why or how patients choose low- or high-volume centers. The purpose of this study was to evaluate how travel burden and hospital volume ... Full text Link to item Cite

Impact of Positive Margins on Survival in Patients Undergoing Esophagogastrectomy for Esophageal Cancer.

Journal Article Ann Thorac Surg · March 2016 BACKGROUND: Multimodality treatment that includes esophagogastrectomy may represent the best option for curing accurately staged patients with esophageal cancer. We analyzed the impact of incomplete resection on outcomes after esophagogastrectomy for esoph ... Full text Link to item Cite

Use and Outcomes of Minimally Invasive Lobectomy for Stage I Non-Small Cell Lung Cancer in the National Cancer Data Base.

Journal Article Ann Thorac Surg · March 2016 BACKGROUND: Previous studies have raised concerns that video-assisted thoracoscopic (VATS) lobectomy may compromise nodal evaluation. The advantages or limitations of robotic lobectomy have not been thoroughly evaluated. METHODS: Perioperative outcomes and ... Full text Link to item Cite

NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 4.2016.

Journal Article J Natl Compr Canc Netw · March 2016 These NCCN Guidelines Insights focus on recent updates in the 2016 NCCN Guidelines for Non-Small Cell Lung Cancer (NSCLC; Versions 1-4). These NCCN Guidelines Insights will discuss new immunotherapeutic agents, such as nivolumab and pembrolizumab, for pati ... Full text Link to item Cite

Modified uniportal video-assisted thoracoscopic surgery (VATS).

Journal Article Ann Cardiothorac Surg · March 2016 Video-assisted thoracoscopic surgery (VATS) for resectable lung cancer patients has been frequently used in the past decades. The potential beneficial advantages and safety of VATS has been shown in large patient series and meta-analyses. The strategy of l ... Full text Link to item Cite

Variation in Definitive Therapy for Localized Non-Small Cell Lung Cancer Among National Comprehensive Cancer Network Institutions.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2016 PURPOSE: This study determined practice patterns in the staging and treatment of patients with stage I non-small cell lung cancer (NSCLC) among National Comprehensive Cancer Network (NCCN) member institutions. Secondary aims were to determine trends in the ... Full text Link to item Cite

Sublobar Resection for Clinical Stage IA Non-small-cell Lung Cancer in the United States.

Journal Article Clin Lung Cancer · January 2016 BACKGROUND: This study evaluated the use of lobectomy and sublobar resection for clinical stage IA non-small-cell lung cancer (NSCLC) in the National Cancer Data Base (NCDB). METHODS: The NCDB from 2003 to 2011 was analyzed to determine factors associated ... Full text Link to item Cite

Recent randomized trials on stage III lung cancer treatment

Journal Article Translational Cancer Research · January 1, 2016 Full text Cite

Management of pulmonary arterial bleeding in the post induction setting.

Journal Article J Vis Surg · 2016 BACKGROUND: A minimally invasive approach to lung cancer resection offers many benefits over traditional open surgery. Pulmonary arterial injury is a widely cited reason for conversion to open surgery. METHODS: We present a case of pulmonary arterial injur ... Full text Link to item Cite

Division of the bronchus: an approach to the intraoperative management of difficult lymphadenopathy.

Journal Article J Vis Surg · 2016 BACKGROUND: A minimally invasive approach to lung cancer resection offers many benefits over traditional open surgery. Reasons for increased difficulty and conversion from thoracoscopic to open surgery have been studied and include abnormal hilar or interl ... Full text Link to item Cite

Troubleshooting hilar and interlobar lymphadenopathy during thoracoscopic lobectomy for benign disease-case report.

Journal Article J Vis Surg · 2016 The completion of thoracoscopic lobectomy can be more difficult in the setting of clinically positive lymph nodes, which may be found in the setting of a proximal tumor causing bronchial obstruction or a larger tumor which may create an inflammatory state, ... Full text Link to item Cite

Adding radiation to induction chemotherapy does not improve survival of patients with operable clinical N2 non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · December 2015 OBJECTIVE: Radiotherapy is commonly used in induction regimens for patients with non-small cell lung cancer with operable mediastinal nodal disease, although evidence has not shown a benefit over induction chemotherapy alone. We compared outcomes between i ... Full text Link to item Cite

The impact of tumor size on the association of the extent of lymph node resection and survival in clinical stage I non-small cell lung cancer.

Journal Article Lung Cancer · December 2015 INTRODUCTION: Lymph node evaluation for node-negative non-small cell lung cancer (NSCLC) is associated with long-term survival but it is not clear if smaller tumors require as extensive a pathologic nodal assessment as larger tumors. This study evaluated t ... Full text Link to item Cite

Invited Commentary.

Other Ann Thorac Surg · December 2015 Full text Link to item Cite

Invited Commentary.

Other Ann Thorac Surg · November 2015 Full text Link to item Cite

Thoracoscopic diaphragm plication.

Journal Article Ann Cardiothorac Surg · November 2015 Full text Link to item Cite

Troubleshooting thoracoscopic anterior mediastinal surgery: lessons learned from thoracoscopic lobectomy.

Journal Article Ann Cardiothorac Surg · November 2015 Video-assisted thoracoscopic surgery (VATS) lobectomy is safe, oncologically effective, and increasingly utilized for lung cancer resection. Lessons from VATS lobectomy experience can guide the use of a VATS approach to resect mediastinal masses. Exposure ... Full text Link to item Cite

An e-score is born.

Other J Thorac Cardiovasc Surg · October 2015 Full text Link to item Cite

Wedge Resection vs Segmentectomy for Patients with T1A N0 Non-Small Cell Lung Cancer

Journal Article JOURNAL OF THORACIC ONCOLOGY · September 1, 2015 Link to item Cite

Growth and Change at NCCN.

Journal Article J Natl Compr Canc Netw · August 2015 Full text Link to item Cite

Improving lung cancer outcomes by improving the quality of surgical care.

Journal Article Transl Lung Cancer Res · August 2015 Surgical resection remains the most important curative treatment modality for non-small cell lung cancer, but variations in short- and long-term surgical outcomes jeopardize the benefit of surgery for certain patients, operated on by certain types of surge ... Full text Link to item Cite

Personalized targeted therapy for esophageal squamous cell carcinoma.

Journal Article World J Gastroenterol · July 7, 2015 Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pres ... Full text Link to item Cite

Impact of Pulmonary Function Measurements on Long-Term Survival After Lobectomy for Stage I Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · July 2015 BACKGROUND: Pulmonary function tests predict respiratory complications after lobectomy. We evaluated the impact of pulmonary function measurements on long-term survival after lobectomy for stage I non-small cell lung cancer. METHODS: The relationship betwe ... Full text Link to item Cite

Long-Term Outcomes of Lobectomy for Non-Small Cell Lung Cancer After Definitive Radiation Treatment.

Journal Article Ann Thorac Surg · June 2015 BACKGROUND: Salvage surgical resection for non-small cell lung cancer (NSCLC) patients initially treated with definitive chemotherapy and radiotherapy can be performed safely, but the long-term benefits are not well characterized. METHODS: Perioperative co ... Full text Link to item Cite

Adjuvant Chemotherapy After Lobectomy for T1-2N0 Non-Small Cell Lung Cancer: Are the Guidelines Supported?

Journal Article J Natl Compr Canc Netw · June 2015 BACKGROUND: Evidence guiding adjuvant chemotherapy (AC) use after lobectomy for stage I non-small cell lung cancer (NSCLC) is limited. This study evaluated the impact of AC use and tumor size on outcomes using a large, nationwide cancer database. METHODS: ... Full text Link to item Cite

Outcomes after treatment of 17,378 patients with locally advanced (T3N0-2) non-small-cell lung cancer.

Journal Article Eur J Cardiothorac Surg · April 2015 OBJECTIVES: Treatment patterns and outcomes in a population-based database were examined to identify patients likely to benefit from surgical resection of locally advanced (T3N0-2) non-small-cell lung cancer (NSCLC). METHODS: Factors predicting the use of ... Full text Link to item Cite

Adjuvant chemotherapy after resection of N1 non-small cell lung cancer: differential impact of new evidence on physician and patient decisions.

Journal Article J Thorac Dis · March 2015 BACKGROUND: Adjuvant cisplatin-based chemotherapy (ACT) after resection of stages II-IIIA non-small cell lung cancer (NSCLC) modestly increased survival in several clinical trials. This study evaluated the subsequent impact of those trials on ACT use in cl ... Full text Link to item Cite

Smoking history predicts for increased risk of second primary lung cancer: a comprehensive analysis.

Journal Article Cancer · February 15, 2015 BACKGROUND: Tobacco use is the most important risk factor for the development of lung cancer. The objective of the current study was to determine the effect of smoking on the development of second primary lung cancers (SPLCs) and other clinical outcomes af ... Full text Link to item Cite

Benefit of adjuvant chemotherapy after resection of stage II (T1-2N1M0) non-small cell lung cancer in elderly patients.

Journal Article Ann Surg Oncol · February 2015 BACKGROUND: We evaluated the use and efficacy of adjuvant chemotherapy after resection of T1-2N1M0 non-small cell lung cancer (NSCLC) in elderly patients. METHODS: Factors associated with the use of adjuvant chemotherapy in patients older than 65 years of ... Full text Open Access Link to item Cite

Esophageal and esophagogastric junction cancers, version 1.2015.

Journal Article J Natl Compr Canc Netw · February 2015 Esophageal cancer is the sixth most common cause of cancer deaths worldwide. Adenocarcinoma is more common in North America and Western European countries, originating mostly in the lower third of the esophagus, which often involves the esophagogastric jun ... Full text Link to item Cite

VATS versus open surgery for lung cancer resection: moving toward a minimally invasive approach.

Journal Article J Natl Compr Canc Netw · February 2015 The use of video-assisted thoracoscopic surgery (VATS) has become the standard approach for the surgical resection of early-stage lung cancer. Although no large prospective, randomized, controlled trial has compared VATS lobectomy with thoracotomy, well-de ... Full text Link to item Cite

Induction chemoradiation therapy prior to esophagectomy is associated with superior long-term survival for esophageal cancer.

Journal Article Dis Esophagus · 2015 The purpose of this study was to examine the role of induction chemoradiation in the treatment of potentially resectable locally advanced (T2-3N0 and T1-3N+) esophageal cancer utilizing a large national database. The National Cancer Data Base (NCDB) was qu ... Full text Link to item Cite

Spontaneous herniation of the lung and diaphragm treated with surgical repair.

Journal Article Ann Thorac Surg · 2015 Lung herniation is rare and is usually caused by blunt trauma, congenital abnormalities of the ribs, or previous thoracic operations. We report a rare case of spontaneous lung herniation in a 72-year-old woman and describe the operative repair. ... Full text Link to item Cite

The prognostic importance of the number of dissected lymph nodes after induction chemoradiotherapy for esophageal cancer.

Journal Article Ann Thorac Surg · January 2015 BACKGROUND: Analyses of adequacy of lymph node dissection during resection of esophageal cancer are based on patients who have not undergone induction chemoradiotherapy. We sought to determine the minimum number of dissected lymph nodes necessary to ensure ... Full text Link to item Cite

Esophageal cancer

Chapter · January 1, 2015 Introduction The incidence of esophageal carcinoma is increasing, with the incidence of esophageal adenocarcinoma increasing faster than any other malignancy in the United States (1). Estimates for 2013 predict 17990 new cases of esophageal carcinoma, acco ... Full text Cite

The History of Duke Thoracic Surgery.

Journal Article Semin Thorac Cardiovasc Surg · 2015 Since 1931, Duke Thoracic Surgery has been defined by excellence in patient care, research, and the education of leaders in surgery. In this work, the history, contributions, historic figures, and current structure of the program are reviewed. The program ... Full text Link to item Cite

Foreword

Journal Article Law & Contemporary Problems · 2015 Open Access Link to item Cite

Modified uniportal video-assisted thoracoscopic lobectomy: Duke approach.

Journal Article Ann Thorac Surg · December 2014 Traditional thoracoscopic strategies using two to four ports has been demonstrated to be oncologically successful for patients with resectable lung cancer, with numerous advantageous over thoracotomy. A single-incision approach has been described, but it i ... Full text Link to item Cite

Defining and improving postoperative care.

Journal Article J Thorac Cardiovasc Surg · November 2014 Although much is known regarding the importance of postoperative care, the surveillance of patients after 30 days from the surgical procedure can be improved. It must be recognized that mortality between 30 and 90 days exceeds what is commonly considered " ... Full text Link to item Cite

Thoracoscopic pneumonectomy in management of histoplasmosis and fibrosing mediastinitis.

Journal Article Ann Thorac Surg · October 2014 Pulmonary histoplasmosis is generally a self-limited respiratory illness in endemic areas. Fibrosing mediastinitis is a severe chronic complication of pulmonary histoplasmosis in which pulmonary vessels and airways can be compressed with the potential for ... Full text Link to item Cite

Challenging cases: thoracoscopic lobectomy with chest wall resection and sleeve lobectomy-Duke experience.

Journal Article J Thorac Dis · October 2014 Video-assisted thoracoscopic surgery (VATS) had recent advances in both equipment and technique so has been applied to more complex conditions in some thoracic surgery centers. We have adopted our VATS lobectomy experience for patients with chest wall inva ... Full text Link to item Cite

Modern impact of video assisted thoracic surgery.

Journal Article J Thorac Dis · October 2014 With advancement in technology, experience and training over the last two decades, video assisted thoracic surgery (VATS) has become widely accepted and utilized all over the world. VATS started as a diagnostic tool in the early 1990s, technique of VATS lo ... Full text Link to item Cite

Surgical excision for mediastinal synovial sarcoma with limited response to chemoradiotherapy.

Journal Article Ann Thorac Surg · September 2014 Primary synovial sarcoma of the mediastinum is an exceedingly rare neoplasm. We describe a 31-year-old woman who had an incidental diagnosis of mediastinal mass. Histopathology and immunohistochemistry analysis confirmed the diagnosis of primary mediastina ... Full text Link to item Cite

Induction therapy does not improve survival for clinical stage T2N0 esophageal cancer.

Journal Article J Thorac Oncol · August 2014 INTRODUCTION: This study compared survival after initial treatment with esophagectomy as primary therapy to induction therapy followed by esophagectomy for patients with clinical T2N0 (cT2N0) esophageal cancer in the National Cancer Database (NCDB). METHOD ... Full text Link to item Cite

Tumor acquisition for biomarker research in lung cancer.

Journal Article Cancer Invest · July 2014 The biopsy collection data from two lung cancer trials that required fresh tumor samples be obtained for microarray analysis were reviewed. In the trial for advanced disease, microarray data were obtained on 50 patient samples, giving an overall success ra ... Full text Link to item Cite

Interinstitutional variation in management decisions for treatment of 4 common types of cancer: A multi-institutional cohort study.

Journal Article Ann Intern Med · July 1, 2014 BACKGROUND: When clinical practice is governed by evidence-based guidelines and there is consensus about their validity, practice variation should be minimal. For areas in which evidence gaps exist, greater variation is expected. OBJECTIVE: To systematical ... Full text Link to item Cite

Surgical Aspects of Thoracic Malignancies

Chapter · June 20, 2014 This chapter presents a series of case studies related to surgical aspects of thoracic malignancies. The first case study is about a 65-year-old smoker with a spiculated, peripheral 2.5 cm right upper lobe mass. Other case studies include a 72-year-old smo ... Full text Cite

The impact of pulmonary hypertension on morbidity and mortality following major lung resection.

Journal Article Eur J Cardiothorac Surg · June 2014 OBJECTIVES: Pulmonary hypertension is considered a poor prognostic factor for or even a contraindication to major lung resection, but evidence for this claim is lacking. This study evaluates the impact of pulmonary hypertension on morbidity and mortality f ... Full text Link to item Cite

Thoracoscopic versus robotic approaches: advantages and disadvantages.

Journal Article Thorac Surg Clin · May 2014 The overall advantages of thoracoscopy over thoracotomy in terms of patient recovery have been fairly well established. The use of robotics, however, is a newer and less proven modality in the realm of thoracic surgery. Robotics offers distinct advantages ... Full text Link to item Cite

The biomolecular era for thoracic surgeons: the example of the ESTS Biology Club.

Journal Article J Thorac Dis · May 2014 Understanding basic mechanisms of lung disease may help to move forward the management of our patients. Molecular biology has affected our diagnostic and therapeutic pathways in the direction of personalized medicine not only for thoracic malignancies. Acc ... Full text Link to item Cite

Mckeown esophagogastrectomy.

Journal Article J Thorac Dis · May 2014 Esophageal cancer is increasing in incidence faster than other cancers in the US. Outcomes after esophagectomy may be related to many factors, including the age of the patient, the stage of the tumor, the operative approach, and the incidence of postoperat ... Full text Link to item Cite

European guidelines on structure and qualification of general thoracic surgery.

Journal Article Eur J Cardiothorac Surg · May 2014 OBJECTIVE: To update the recommendations for the structural characteristics of general thoracic surgery (GTS) in Europe in order to provide a document that can be used as a guide for harmonizing the general thoracic surgical practice in Europe. METHODS: A ... Full text Link to item Cite

Video-assisted thoracoscopic surgery lobectomy at 20 years: a consensus statement.

Journal Article Eur J Cardiothorac Surg · April 2014 OBJECTIVE: Video-assisted thoracoscopic surgery (VATS) lobectomy has been gradually accepted as an alternative surgical approach to open thoracotomy for selected patients with non-small-cell lung cancer (NSCLC) over the past 20 years. The aim of this proje ... Full text Link to item Cite

Survival in the elderly after pneumonectomy for early-stage non-small cell lung cancer: a comparison with nonoperative management.

Journal Article J Am Coll Surg · March 2014 BACKGROUND: Short-term outcomes of morbidity, mortality, and quality of life after pneumonectomy worsen with increasing age. The impact of age on long-term outcomes has not been well described. The purpose of this study was to quantify the impact of patien ... Full text Link to item Cite

Open, thoracoscopic and robotic segmentectomy for lung cancer.

Journal Article Ann Cardiothorac Surg · March 2014 While lobectomy is the standard procedure for early stage lung cancer, the role of sublobar resection is currently under investigation for selected patients with small tumors. In this review, studies reporting outcomes on open, thoracoscopic and robotic se ... Full text Link to item Cite

Reply: To PMID 23545195.

Other Ann Thorac Surg · January 2014 Full text Link to item Cite

Issues with implementing a high-quality lung cancer screening program.

Journal Article CA Cancer J Clin · 2014 After a comprehensive review of the evidence, the United States Preventive Services Task Force recently endorsed screening with low-dose computed tomography as an early detection approach that has the potential to significantly reduce deaths due to lung ca ... Full text Link to item Cite

Discussion

Journal Article Journal of Thoracic and Cardiovascular Surgery · January 1, 2014 Full text Cite

Preface

Other Journal of Thoracic Disease · January 1, 2014 Full text Cite

Surgical techniques and results of the pulmonary artery reconstruction for patients with central non-small cell lung cancer.

Journal Article J Cardiothorac Surg · December 1, 2013 BACKGROUND: It is difficult to achieve a margin-negative resection (R0) for non-small cell lung cancer (NSCLC) patients with infiltration of the pulmonary artery. We report our experience of the pulmonary artery reconstruction with regard to long-term surv ... Full text Link to item Cite

Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery.

Journal Article Stroke · December 2013 BACKGROUND AND PURPOSE: Neurocognitive decline occurs frequently after cardiac surgery and persists in a significant number of patients. Magnesium is thought to provide neuroprotection by preservation of cellular energy metabolism, blockade of the N-methyl ... Full text Link to item Cite

Management of T2N0 Esophageal Cancer Reply

Other ANNALS OF THORACIC SURGERY · November 1, 2013 Link to item Cite

Reply: To PMID 23063200.

Other Ann Thorac Surg · November 2013 Full text Link to item Cite

Extensive invasion of the left atrium by lung cancer.

Journal Article Ann Thorac Surg · August 2013 A 52-year-old man complained of cough and hemoptysis for 1 month. Chest computed tomography scan revealed a 9 cm × 7 cm right lung mass invading the right inferior pulmonary vein and left atrium extensively, and the inferior pulmonary vein was completely o ... Full text Link to item Cite

Contraindications of video-assisted thoracoscopic surgical lobectomy and determinants of conversion to open.

Journal Article J Thorac Dis · August 2013 Since the introduction of anatomic lung resection by video-assisted thoracoscopic surgery (VATS) was introduced 20 years ago, VATS has experienced major advances in both equipment and technique, introducing a technical challenge in the surgical treatment o ... Full text Link to item Cite

Prospective phase II trial of preresection thoracoscopic mediastinal restaging after neoadjuvant therapy for IIIA (N2) non-small cell lung cancer: results of CALGB Protocol 39803.

Journal Article J Thorac Cardiovasc Surg · July 2013 OBJECTIVE: Accurate pathologic restaging of N2 stations after neoadjuvant therapy in stage IIIA (N2) non-small cell lung cancer is needed. METHODS: A prospective multi-institutional trial was designed to judge the feasibility of videothoracoscopy to restag ... Full text Link to item Cite

Treatment modalities for T1N0 esophageal cancers: a comparative analysis of local therapy versus surgical resection.

Journal Article J Thorac Oncol · June 2013 BACKGROUND: To investigate the role of nonsurgical treatment for early-stage esophageal cancer, we compared the outcomes of local therapy to esophagectomy, using a large, national database. METHODS: Five-year cancer-specific and overall survival (OS) of pa ... Full text Link to item Cite

Non-small cell lung cancer, version 2.2013.

Journal Article J Natl Compr Canc Netw · June 1, 2013 These NCCN Guidelines Insights focus on the diagnostic evaluation of suspected lung cancer. This topic was the subject of a major update in the 2013 NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Non-Small Cell Lung Cancer. The NCCN Gu ... Full text Link to item Cite

Diabetes mellitus: A significant co-morbidity in the setting of lung cancer?

Journal Article Thorac Cancer · May 2013 BACKGROUND: To evaluate the effect of diabetes mellitus (DM) on clinical outcomes in patients managed surgically for non-small cell lung cancer (NSCLC). METHODS: Patients who underwent surgery for pathological I-IIIA NSCLC at Duke University from 1995-2005 ... Full text Link to item Cite

Thymomas and thymic carcinomas: Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · May 1, 2013 Masses in the anterior mediastinum can be neoplasms (eg, thymomas, thymic carcinomas, or lung metastases) or non-neoplastic conditions (eg, intrathoracic goiter). Thymomas are the most common primary tumor in the anterior mediastinum, although they are rar ... Full text Link to item Cite

Abstract LB-296: FDG-PET avidity negatively impacts survival in pStage I NSCLC in the ACOSOG Z4031 trial.

Conference Cancer Research · April 15, 2013 AbstractBackground: Fluoro-deoxyglucose positron emission tomography (FDG-PET) scans are used for diagnosis and staging of known or suspected non-small cell lung cancer (NSCLC). Single institution studies ex ... Full text Cite

The best that surgery has to offer.

Journal Article J Thorac Cardiovasc Surg · March 2013 Full text Link to item Cite

The role of radiation therapy in resected T2 N0 esophageal cancer: a population-based analysis.

Journal Article Ann Thorac Surg · February 2013 BACKGROUND: The prognosis of even early-stage esophageal cancer is poor. Because there is not a consensus on how to manage T2 N0 disease, we examined survival after resection of T2 N0 esophageal cancer, with or without radiation therapy. METHODS: Patients ... Full text Link to item Cite

Impact of the 7th Edition AJCC staging classification on the NCCN clinical practice guidelines in oncology for gastric and esophageal cancers.

Journal Article J Natl Compr Canc Netw · January 1, 2013 The 7th edition of the AJCC Cancer Staging Manual has attempted to harmonize gastric and esophageal cancers, including management of gastroesophageal junction (GEJ)-type tumors. The treatment of complex tumor types is best guided by a staging classificatio ... Full text Link to item Cite

Does surgery improve outcomes for esophageal squamous cell carcinoma? An analysis using the surveillance epidemiology and end results registry from 1998 to 2008.

Journal Article J Am Coll Surg · November 2012 BACKGROUND: We examined survival associated with locally advanced esophageal squamous cell cancer (SCC) to evaluate if treatment without surgery could be considered adequate. STUDY DESIGN: Patients in the Surveillance, Epidemiology and End Results Registry ... Full text Open Access Link to item Cite

Non-small cell lung cancer.

Journal Article J Natl Compr Canc Netw · October 1, 2012 Most patients with non-small cell lung cancer (NSCLC) are diagnosed with advanced cancer. These guidelines only include information about stage IV NSCLC. Patients with widespread metastatic disease (stage IV) are candidates for systemic therapy, clinical t ... Full text Link to item Cite

Thoracoscopic lobectomy has increasing benefit in patients with poor pulmonary function: a Society of Thoracic Surgeons Database analysis.

Journal Article Ann Surg · September 2012 OBJECTIVE: Using a national database, we asked whether video-assisted thoracoscopic surgery (VATS) lobectomy is beneficial in high-risk pulmonary patients. BACKGROUND: Single-institution series demonstrated benefit of VATS lobectomy over lobectomy via thor ... Full text Link to item Cite

Invited commentary.

Other Ann Thorac Surg · September 2012 Full text Link to item Cite

Radiation therapy at the end of life in patients with incurable nonsmall cell lung cancer.

Journal Article Cancer · September 1, 2012 BACKGROUND: Receipt of chemotherapy at the end of life (EOL) is considered an indicator of poor quality of care for medical oncology. The objective of this study was to characterize the use of radiotherapy (RT) in patients with nonsmall cell lung cancer (N ... Full text Link to item Cite

Optimal management of malignant pleural effusions (results of CALGB 30102).

Journal Article J Natl Compr Canc Netw · August 2012 The optimal strategy to achieve palliation of malignant pleural effusions (MPEs) is unknown. This multi-institutional, prospective, randomized trial compares 2 established methods for controlling symptomatic unilateral MPEs. Patients with unilateral MPEs w ... Full text Link to item Cite

Needs assessment for an errors-based curriculum on thoracoscopic lobectomy.

Journal Article Ann Thorac Surg · August 2012 BACKGROUND: Research suggests a benefit from a skills curriculum emphasizing error prevention, identification, and management. Our purpose was to identify common errors committed by trainees during simulated thoracoscopic lobectomy for use in developing an ... Full text Link to item Cite

Thoracoscopic segmentectomy for lung cancer.

Journal Article Ann Thorac Surg · August 2012 Lobectomy has long been considered the standard procedure for early-stage lung cancer, and minimally invasive techniques have been demonstrated to be associated with superior outcomes compared with lobectomy by thoracotomy. The use of segmentectomy is unde ... Full text Link to item Cite

Validation of a thoracoscopic lobectomy simulator.

Journal Article Eur J Cardiothorac Surg · August 2012 OBJECTIVES: Although simulation is considered integral to general surgery training, its role has only recently been recognized in thoracic surgical education, perhaps due to a lack of widely available, validated simulators for advanced thoracic procedures. ... Full text Link to item Cite

Lymphovascular invasion in non-small-cell lung cancer: implications for staging and adjuvant therapy.

Journal Article J Thorac Oncol · July 2012 BACKGROUND: Lymphovascular space invasion (LVI) is an established negative prognostic factor and an indication for postoperative radiation therapy in many malignancies. The purpose of this study was to evaluate LVI in patients with early-stage non-small-ce ... Full text Link to item Cite

First-line systemic therapy practice patterns and concordance with NCCN guidelines for patients diagnosed with metastatic NSCLC treated at NCCN institutions.

Journal Article J Natl Compr Canc Netw · July 1, 2012 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) allow many systemic therapy options for patients with metastatic non-small cell lung cancer (NSCLC). This analysis uses the NCCN NSCLC Outcomes Database to report on first-line therapy pra ... Full text Link to item Cite

Induction chemoradiation is not superior to induction chemotherapy alone in stage IIIA lung cancer.

Journal Article Ann Thorac Surg · June 2012 BACKGROUND: The optimal treatment strategy for patients with operable stage IIIA (N2) non-small cell lung cancer is uncertain. We performed a systematic review and meta-analysis to test the hypothesis that the addition of radiotherapy to induction chemothe ... Full text Link to item Cite

Accuracy of FDG-PET to diagnose lung cancer in the ACOSOG Z4031 trial.

Conference JOURNAL OF CLINICAL ONCOLOGY · May 20, 2012 Link to item Cite

The management of patients with stage IIIA non-small cell lung cancer with N2 mediastinal node involvement.

Journal Article J Natl Compr Canc Netw · May 2012 Patients with stage IIIA non-small cell lung cancer, determined based on involvement of ipsilateral mediastinal lymph nodes, represent the most challenging management problem in this disease. Patients with this stage disease may have very different degrees ... Full text Link to item Cite

Effect of increasing experience on dosimetric and clinical outcomes in the management of malignant pleural mesothelioma with intensity-modulated radiation therapy.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2012 PURPOSE: To assess the impact of increasing experience with intensity-modulated radiation therapy (IMRT) after extrapleural pneumonectomy (EPP) for malignant pleural mesothelioma (MPM). METHODS AND MATERIALS: The records of all patients who received IMRT f ... Full text Link to item Cite

Outcomes after surgical management of synchronous bilateral primary lung cancers.

Journal Article Ann Thorac Surg · April 2012 BACKGROUND: Distinguishing between synchronous primary lung cancers and metastatic disease in patients with bilateral lung masses is often difficult. The objective of this study is to examine outcomes associated with a strategy of performing staged bilater ... Full text Link to item Cite

Feasibility of hybrid thoracoscopic lobectomy and en-bloc chest wall resection.

Journal Article Eur J Cardiothorac Surg · April 2012 OBJECTIVES: Lobectomy with an en-bloc chest wall resection is an effective but potentially morbid treatment of lung cancer invading the chest wall. Minimally invasive approaches to lobectomy have reduced morbidity compared with thoracotomy for early stage ... Full text Link to item Cite

Message from the chair of the NCCN Board of Directors

Other JNCCN Journal of the National Comprehensive Cancer Network · April 1, 2012 Full text Cite

Molecular biology of lung cancer

Chapter · January 5, 2012 Cite

Diaphragmatic pacing

Chapter · January 5, 2012 Cite

Discussion

Other Journal of Thoracic and Cardiovascular Surgery · January 1, 2012 Full text Cite

Malignant pleural mesothelioma.

Journal Article J Natl Compr Canc Netw · January 2012 Full text Link to item Cite

VATS versus thoracotomy for major lung resection after induction therapy

Chapter · December 1, 2011 Induction therapy has been considered a risk factor for morbidity and mortality after major lung resection via thoracotomy, but has been demonstrated to be feasible and effective in both prospective trials and retrospective studies. Induction therapy was i ... Full text Cite

Perioperative management of patients on clopidogrel (Plavix) undergoing major lung resection.

Journal Article Ann Thorac Surg · December 2011 BACKGROUND: Management of patients requiring antiplatelet therapy with clopidogrel (Plavix) and major lung resection must balance the risks of bleeding and cardiovascular events. We reviewed our experience with patients treated with clopidogrel perioperati ... Full text Link to item Cite

Persistent N2 disease after neoadjuvant chemotherapy for non-small-cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · November 2011 OBJECTIVES: Patients achieving a mediastinal pathologic complete response with neoadjuvant chemotherapy have improved outcomes compared with patients with persistent N2 disease. How to best manage this latter group of patients is unknown, prompting a revie ... Full text Link to item Cite

Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle.

Journal Article BMC Med Genomics · October 5, 2011 BACKGROUND: The accurate diagnosis of idiopathic pulmonary fibrosis (IPF) is a major clinical challenge. We developed a model to diagnose IPF by applying Bayesian probit regression (BPR) modelling to gene expression profiles of whole lung tissue. METHODS: ... Full text Link to item Cite

A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery.

Journal Article J Anesth · October 2011 PURPOSE: We hypothesized that patients who received ketamine during thoracic surgery would benefit from suppression of the inflammatory cascade, represented by lower interleukin (IL)-6 and C-reactive protein (CRP) plasma levels. METHODS: This study was a r ... Full text Link to item Cite

Bronchoscopic lung-volume reduction with Exhale airway stents for emphysema (EASE trial): randomised, sham-controlled, multicentre trial.

Journal Article Lancet · September 10, 2011 BACKGROUND: Airway bypass is a bronchoscopic lung-volume reduction procedure for emphysema whereby transbronchial passages into the lung are created to release trapped air, supported with paclitaxel-coated stents to ease the mechanics of breathing. The aim ... Full text Link to item Cite

Invited commentary.

Other Ann Thorac Surg · September 2011 Full text Link to item Cite

Improving outcomes after esophagectomy: the importance of preventing postoperative pneumonia.

Other Zhonghua Wei Chang Wai Ke Za Zhi · September 2011 Outcomes after esophagectomy may be related to many factors, including the age of the patient, the stage of the tumor, the operative approach, and the incidence of postoperative morbidity. Pulmonary complications are the major source of morbidity and morta ... Link to item Cite

Incorporating research into thoracic surgery practice.

Journal Article Thorac Surg Clin · August 2011 The incorporation of research into a career in thoracic surgery is a complex process. Ideally, the preparation for a career in academic thoracic surgery begins with a research fellowship during training. In the academic setting, a research portfolio might ... Full text Link to item Cite

Esophageal and esophagogastric junction cancers.

Journal Article J Natl Compr Canc Netw · August 1, 2011 Full text Link to item Cite

Efficacy of mediastinal lymph node dissection during lobectomy for lung cancer by thoracoscopy and thoracotomy.

Journal Article Ann Thorac Surg · July 2011 BACKGROUND: Mediastinal lymph node dissection (MLND) is an integral component of complete resection for non-small cell lung cancer (NSCLC). This study analyzed the National Comprehensive Cancer Network's (NCCN) NSCLC Database to compare the efficacy of MLN ... Full text Link to item Cite

Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.

Journal Article Ann Thorac Surg · June 2011 BACKGROUND: Inclusion of a measure of left ventricular diastolic dysfunction (LVDD) may improve risk prediction after cardiac surgery. Current LVDD grading guidelines rely on echocardiographic variables that are not always available or aligned to allow gra ... Full text Link to item Cite

A model for morbidity after lung resection in octogenarians.

Journal Article Eur J Cardiothorac Surg · June 2011 OBJECTIVE: Age is an important risk factor for morbidity after lung resection. This study was performed to identify specific risk factors for complications after lung resection in octogenarians. METHODS: A prospective database containing patients aged 80 y ... Full text Link to item Cite

PERSISTENT N2 DISEASE AFTER NEOADJUVANT CHEMOTHERAPY-NOW WHAT?

Conference JOURNAL OF THORACIC ONCOLOGY · June 1, 2011 Link to item Cite

Proteomic analysis for detection of NSCLC: Results of ACOSOG Z4031.

Conference Journal of Clinical Oncology · May 20, 2011 Full text Cite

Proteomic analysis for detection of NSCLC: Results of ACOSOG Z4031.

Journal Article J Clin Oncol · May 20, 2011 7003 Background: NCI CT Screening Trial demonstrated a significant decrease in lung cancer mortality. This will dramatically increase the number of suspicious nodules discovered by CT. Unfortunately CT scans have a high false-positive rate for lung cancer ... Link to item Cite

Aggressive end-of-life (EOL) chemotherapy (CT) use in metastatic non-small cell lung cancer (mNSCLC): A National Comprehensive Cancer Network (NCCN) outcomes database analysis.

Journal Article J Clin Oncol · May 20, 2011 7537 Background: Aggressive EOL cancer care is a health care quality and cost issue. As lung cancer is the leading cause of cancer-related death in the U.S., and NCCN member institutions are considered to offer high-quality, evidence-based care, we examine ... Link to item Cite

How well does the new lung cancer staging system predict for local/regional recurrence after surgery?: A comparison of the TNM 6 and 7 systems.

Journal Article J Thorac Oncol · April 2011 INTRODUCTION: To evaluate how well the tumor, node, metastasis (TNM) 6 and TNM 7 staging systems predict rates of local/regional recurrence (LRR) after surgery alone for non-small cell lung cancer. METHODS: All patients who underwent surgery for non-small ... Full text Link to item Cite

A 10-gene progenitor cell signature predicts poor prognosis in lung adenocarcinoma.

Journal Article Ann Thorac Surg · April 2011 BACKGROUND: One aspect of the cancer stem cell hypothesis is that patients with tumors that exhibit stem-like phenotypes have poor prognoses. Distal epithelial progenitors from lungs early in development demonstrate both self-renewal and potential to diffe ... Full text Link to item Cite

Discussion

Other Journal of Thoracic and Cardiovascular Surgery · March 1, 2011 Full text Cite

Invited commentary.

Other Ann Thorac Surg · February 2011 Full text Link to item Cite

Technique of thoracoscopic basilar segmentectomy.

Journal Article Semin Thorac Cardiovasc Surg · 2011 Full text Link to item Cite

"Reality surgery"--a research ethics perspective on the live broadcast of surgical procedures.

Journal Article J Surg Educ · 2011 In recent years, the live broadcasting of medical and surgical procedures has gained worldwide popularity. While the practice has appropriately been met with concerns for patient safety and privacy, many physicians tout the merits of real time viewing as a ... Full text Link to item Cite

A comprehensive evaluation for aspiration after esophagectomy reduces the incidence of postoperative pneumonia.

Journal Article J Thorac Cardiovasc Surg · December 2010 OBJECTIVE: This study assesses the effect of using a comprehensive swallowing evaluation before starting oral feedings on aspiration detection and pneumonia occurrence after esophagectomy. METHODS: The records of all patients undergoing esophagectomy betwe ... Full text Link to item Cite

Thymic malignancies.

Journal Article J Natl Compr Canc Netw · November 2010 Full text Link to item Cite

The Effect of Increasing Experience with Intensity Modulated Radiation Therapy for Resected Malignant Pleural Mesothelioma

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Surgical techniques to avoid parenchymal injury during lung resection (fissureless lobectomy).

Journal Article Thorac Surg Clin · August 2010 Thoracoscopic lobectomy has become an accepted, safe, and oncologically sound procedure compared with open lobectomy. Several studies have reported that it reduces the length of stay, postoperative pain, and postoperative complications, including air leaks ... Full text Link to item Cite

Risk factors for atrial fibrillation after lung cancer surgery: analysis of the Society of Thoracic Surgeons general thoracic surgery database.

Journal Article Ann Thorac Surg · August 2010 BACKGROUND: Atrial fibrillation is responsible for significant morbidity after lung cancer surgery, and preoperative and perioperative risk factors are not well described. METHODS: The Society of Thoracic Surgeons (STS) database was queried for all lobecto ... Full text Link to item Cite

Ethics in cardiothoracic surgery: a survey of surgeons' views.

Journal Article Ann Thorac Surg · July 2010 BACKGROUND: Cardiothoracic surgeons are frequently confronted with complex ethical issues. Educational efforts to help surgeons navigate such issues have been undertaken in recent years, but their effectiveness is uncertain. METHODS: A survey instrument ex ... Full text Link to item Cite

Non-small cell lung cancer.

Journal Article J Natl Compr Canc Netw · July 2010 Full text Link to item Cite

Operative techniques in early-stage lung cancer.

Journal Article J Natl Compr Canc Netw · July 2010 Lung cancer is the most common cause of death by malignancy, responsible for more deaths than the next 4 causes combined and predicted to account for nearly 220,000 new cancer diagnoses and 160,000 deaths in 2009. The cornerstone of therapy for early-stage ... Full text Link to item Cite

Thoracoscopic lobectomy: the gold standard for early-stage lung cancer?

Journal Article Ann Thorac Surg · June 2010 Primary lung cancers remain the most lethal of all the malignancies, predicted to account for nearly 160,000 deaths and 220,000 new diagnoses in 2009. The cornerstone of therapy for early-stage lung cancer is surgical resection by lobectomy with concomitan ... Full text Link to item Cite

Videothoracoscopic mediastinal lymphadenectomy.

Journal Article Thorac Surg Clin · May 2010 Mediastinal lymph node dissection improves the staging of patients who have non-small cell lung cancer at the time of resection. Thoracoscopic lobectomy is seen as an effective strategy for patients who have early-stage lung cancer. Videothoracoscopic lymp ... Full text Link to item Cite

A cost-minimisation analysis of lobectomy: thoracoscopic versus posterolateral thoracotomy.

Journal Article Eur J Cardiothorac Surg · April 2010 OBJECTIVE: Recent evidence suggests that lobectomy performed either through thoracoscopy (TL) or via a posterolateral thoracotomy (PLT) produces equivalent oncologic outcomes in appropriately selected patients. Advantages of thoracoscopic lobectomy include ... Full text Link to item Cite

Pulmonary function tests do not predict pulmonary complications after thoracoscopic lobectomy.

Journal Article Ann Thorac Surg · April 2010 BACKGROUND: Pulmonary function tests predict respiratory complications and mortality after lung resection through thoracotomy. We sought to determine the impact of pulmonary function tests upon complications after thoracoscopic lobectomy. METHODS: A model ... Full text Link to item Cite

Primary chest wall tumors.

Journal Article J Am Coll Surg · March 2010 Full text Link to item Cite

An inexpensive, reproducible tissue simulator for teaching thoracoscopic lobectomy.

Journal Article Ann Thorac Surg · February 2010 PURPOSE: Simulation is rapidly becoming an integral part of surgical education at all levels including the education of practicing surgeons in new techniques such as thoracoscopic lobectomy. Current thoracoscopic lobectomy simulator models have significant ... Full text Link to item Cite

Thoracoscopic lobectomy is associated with lower morbidity than open lobectomy: a propensity-matched analysis from the STS database.

Journal Article J Thorac Cardiovasc Surg · February 2010 BACKGROUND: Several single-institution series have demonstrated that compared with open thoracotomy, video-assisted thoracoscopic lobectomy may be associated with fewer postoperative complications. In the absence of randomized trials, we queried the Societ ... Full text Link to item Cite

Outcomes of video-assisted thoracoscopic decortication.

Journal Article Ann Thorac Surg · January 2010 BACKGROUND: Video-assisted thoracoscopic surgical decortication (VATSD) is widely used for treatment of early empyema and hemothorax, but conversion to open thoracotomy for decortication (OD) is more frequent in the setting of complex, chronic empyema. Thi ... Full text Link to item Cite

Discussion

Other Annals of Thoracic Surgery · January 1, 2010 Full text Cite

Surgical management of pulmonary metastases.

Journal Article Ann Thorac Surg · December 2009 Metastasectomy is the only curative option for some patients with secondary pulmonary malignancy. Many studies suggest a survival benefit in selected patients if complete resection of pulmonary metastases is accomplished. There are several operative approa ... Full text Link to item Cite

Preoperative chemotherapy versus preoperative chemoradiotherapy for stage III (N2) non-small-cell lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2009 PURPOSE: To compare preoperative chemotherapy (ChT) and preoperative chemoradiotherapy (ChT-RT) in operable Stage III non-small-cell lung cancer. METHODS AND MATERIALS: This retrospective study analyzed all patients with pathologically confirmed Stage III ... Full text Link to item Cite

Local recurrence after surgery for early stage lung cancer: an 11-year experience with 975 patients.

Journal Article Cancer · November 15, 2009 BACKGROUND: The objective of the current study was to evaluate the actuarial risk of local failure (LF) after surgery for stage I to II nonsmall cell lung cancer (NSCLC) and assess surgical and pathologic factors affecting this risk. METHODS: The records, ... Full text Link to item Cite

Reply

Other Annals of Thoracic Surgery · November 1, 2009 Full text Cite

Risk factors for morbidity after lobectomy for lung cancer in elderly patients.

Journal Article Ann Thorac Surg · October 2009 BACKGROUND: Studies evaluating risk factors for complications after lobectomy in elderly patients have not adequately analyzed the effect of using minimally invasive approaches. METHODS: A model for morbidity including published preoperative risk factors a ... Full text Link to item Cite

Foreword

Other Law and Contemporary Problems · September 1, 2009 This issue is dedicated to Jerome McCristal Culp, Jr. (1950-2004), who mentored and nurtured many of the contributors to this issue during his life and who continues to teach and to motivate us through his writings. It is also dedicated to Amos Mills, III, ... Cite

Thoracoscopic lobectomy is associated with lower morbidity compared with thoracotomy.

Journal Article J Thorac Cardiovasc Surg · August 2009 OBJECTIVES: Advantages of thoracoscopic lobectomy include less postoperative pain, shorter hospitalization, and improved delivery of adjuvant chemotherapy. The incidence of postoperative complications has not been thoroughly assessed. This study analyzes m ... Full text Link to item Cite

Lung volume reduction surgery for the management of refractory dyspnea in chronic obstructive pulmonary disease.

Journal Article Curr Opin Support Palliat Care · June 2009 PURPOSE OF REVIEW: This review describes the role of lung volume reduction surgery (LVRS) for the management of refractory dyspnea and other debilitating conditions in patients with chronic obstructive pulmonary disease. Recent studies, including a randomi ... Full text Link to item Cite

Prognostic factors for recurrence after pulmonary resection of colorectal cancer metastases.

Journal Article Ann Thorac Surg · June 2009 BACKGROUND: This study was undertaken to review a large series of resections of colorectal pulmonary metastases in the era of modern chemotherapy. METHODS: A retrospective chart review of prospectively maintained thoracic surgery databases identified 378 p ... Full text Link to item Cite

Intraoperative sentinel node mapping with technitium-99 in lung cancer: results of CALGB 140203 multicenter phase II trial.

Journal Article J Thorac Oncol · February 2009 INTRODUCTION: Sentinel node mapping with radioactive technetium in non-small cell lung cancer has been shown to be feasible in several single institution reports. The Cancer and Leukemia Group B designed a phase II trial to test a standardized method of th ... Full text Link to item Cite

No heroic measures: how soon is too soon to stop?

Journal Article Ann Thorac Surg · January 2009 Full text Link to item Cite

Detection of occult N2 disease with molecular techniques.

Journal Article Thorac Surg Clin · November 2008 Lymph node involvement is the most important factor affecting the prognosis and treatment of patients with potentially resectable NSCLC. Radiographic imaging is inadequate to ascertain lymph node involvement accurately. Currently, lymph nodes are histologi ... Full text Link to item Cite

Esophageal cancer.

Journal Article J Natl Compr Canc Netw · October 2008 Link to item Cite

Quality of life outcomes are equivalent after lobectomy in the elderly.

Journal Article J Thorac Cardiovasc Surg · September 2008 OBJECTIVE: Prospective analyses of quality of life in elderly patients after lobectomy are limited, yet surgeons often recommend suboptimal therapy to these patients on the basis of the belief that lobectomy is poorly tolerated. Surgical decision making in ... Full text Link to item Cite

Technique of Thoracoscopic Segmentectomy

Journal Article Operative Techniques in Thoracic and Cardiovascular Surgery · September 1, 2008 Full text Cite

Long-term outcomes of thoracoscopic lobectomy.

Journal Article Thorac Surg Clin · August 2008 Thoracoscopic lobectomy is emerging as the procedure of choice for patients with early stage non-small cell lung cancer, based on advantages in quality of life as well as long-term outcomes. In addition, thoracoscopic lobectomy has been demonstrated to be ... Full text Link to item Cite

Thoracoscopic lobectomy for the management of non-small cell lung cancer.

Journal Article Curr Oncol Rep · July 2008 Surgical resection is the primary treatment for early-stage non-small cell lung cancer (NSCLC). While open thoracotomy is the most frequently performed approach for lobectomy, minimally invasive surgical resection is a safe and viable alternative. Thoracos ... Full text Link to item Cite

Surgery for esophageal cancer.

Journal Article Gastrointest Cancer Res · July 2008 Management of patients with esophageal cancer requires local therapy (surgery or radiation therapy) and systemic therapy, following evidence-based guidelines and stage-specific approaches. Esophagogastrectomy is associated with considerable morbidity and m ... Link to item Cite

Intrathoracic desmoid tumor: brief report and review of literature.

Journal Article J Thorac Oncol · June 2008 INTRODUCTION: The chest wall is the most common extraabdominal site for desmoid tumors. However, true intrathoracic desmoid tumors are exceedingly rare with most cases actually representing intrathoracic extension of chest wall tumors. A comprehensive revi ... Full text Link to item Cite

Adult tracheoesophageal fistula: A multidisciplinary approach

Journal Article Clinical Pulmonary Medicine · May 1, 2008 Fistulization between the respiratory and gastrointestinal tracts is an uncommon problem that results from a spectrum of disease processes. Tracheoesophageal fistula (TEF) formation can be either acquired or congenital; the congenital variety is a rare pro ... Full text Cite

A phase I study of UFT/leucovorin, carboplatin, and paclitaxel in combination with external beam radiation therapy for advanced esophageal carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2008 PURPOSE: Concurrent chemotherapy and radiation therapy (RT) are used to treat patients with esophageal cancer. The optimal combination of chemotherapeutic agents with RT is not well established. We evaluated the safety and preliminary efficacy of a combina ... Full text Link to item Cite

Non-small cell lung cancer.

Journal Article J Natl Compr Canc Netw · March 2008 Full text Link to item Cite

Molecular biologic staging of lung cancer.

Journal Article Ann Thorac Surg · February 2008 Clinical and pathologic staging of lung cancer is suboptimal in achieving the goals of assessing prognosis and selecting therapy. Although the technologic developments that allow the generalized use of proteomic and genomic analyses are relatively recent, ... Full text Link to item Cite

Review and recent development of angle-resolved low-coherence interferometry for detection of precancerous cells in human esophageal epithelium

Journal Article IEEE Journal on Selected Topics in Quantum Electronics · January 1, 2008 The combination of low-coherence interferometry with angle-resolved light scattering measurements has been shown to be a powerful method for determining the structure of cell nuclei within intact tissue samples. The nuclear morphology data have been used a ... Full text Cite

Positron emission tomography in esophageal cancer.

Journal Article Gastrointest Cancer Res · January 2008 Link to item Cite

Radiofrequency ablation for primary lung cancer and pulmonary metastases.

Journal Article Clin Lung Cancer · January 2008 Lung cancer remains one of the leading causes of death throughout the world. Although surgery is the gold standard treatment for lung cancer, the majority of patients are not resectable at the time of diagnosis. Even among patients who are potentially rese ... Full text Link to item Cite

Induction therapy for clinical stage i lung cancer

Chapter · December 1, 2007 Non-small cell lung cancer (NSCLC) remains a leading cause of death and will cause approximately 163,500 deaths in the United States in 2005. While patients presenting with localized disease have the best chance of being cured, they represent a minority of ... Full text Cite

Video-assisted thoracic surgery lobectomy: report of CALGB 39802--a prospective, multi-institution feasibility study.

Journal Article J Clin Oncol · November 1, 2007 PURPOSE: To evaluate the technical feasibility and safety of video-assisted thoracic surgery (VATS) lobectomy for small lung cancers. PATIENTS AND METHODS: The Cancer and Leukemia Group B 39802 trial was a prospective, multi-institutional study designed to ... Full text Link to item Cite

Paclitaxel-based chemoradiotherapy in the treatment of patients with operable esophageal cancer.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2007 PURPOSE: To compare a neoadjuvant regimen of cisplatin/5-fluorouracil (5-FU) and concurrent radiation therapy (RT) with paclitaxel-based regimens and RT in the management of operable esophageal (EC)/gastroesophageal junction (GEJ) cancer. METHODS AND MATER ... Full text Link to item Cite

Stage and Treatment Migration in Patients With Stage III Non-Small Cell Lung Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Pulmonary segmentectomy by thoracotomy or thoracoscopy: reduced hospital length of stay with a minimally-invasive approach.

Journal Article Ann Thorac Surg · October 2007 BACKGROUND: Previous studies have discouraged limited pulmonary resection for primary lung cancer, but pulmonary segmentectomy has advantages for some patients. Furthermore, while thoracoscopic lobectomy has been increasingly applied with well-demonstrated ... Full text Link to item Cite

Outcomes after surgery for esophageal cancer.

Journal Article Gastrointest Cancer Res · September 2007 Esophageal cancer is a virulent malignancy associated with a 5-year overall survival of approximately 5%. Treatment remains controversial-despite the results of prospective, randomized trials of combined-modality therapy-because results are poor with all s ... Link to item Cite

Thoracoscopic lobectomy facilitates the delivery of chemotherapy after resection for lung cancer.

Journal Article Ann Thorac Surg · April 2007 BACKGROUND: We conducted a study of patients who underwent anatomic resection with adjuvant chemotherapy to determine if thoracoscopic lobectomy enables more effective administration of adjuvant chemotherapy than lobectomy by thoracotomy. METHODS: We revie ... Full text Link to item Cite

A Phase I study of capecitabine, carboplatin, and paclitaxel with external beam radiation therapy for esophageal carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2007 PURPOSE: Concurrent chemotherapy and radiation therapy (RT) are used to treat patients with esophageal cancer. The optimal combination of chemotherapeutic agents with RT is undefined. We evaluated a combination of capecitabine, carboplatin, and paclitaxel ... Full text Link to item Cite

In situ detection of nuclear atypia in Barrett's esophagus by using angle-resolved low-coherence interferometry.

Journal Article Gastrointest Endosc · March 2007 BACKGROUND: Monitoring of patients with Barrett's esophagus (BE) for dysplasia, currently done by systematic biopsy, can be improved through increasing the proportion of at-risk tissue examined. OBJECTIVE: Optical biopsy techniques, which do not remove the ... Full text Link to item Cite

Molecular biologic staging and selection of therapy for non-small cell lung cancer

Journal Article Journal of Medical Sciences · February 1, 2007 The optimal staging system achieves accurate assessment of extent of disease, effective prognostic stratification, and selection of appropriate therapy. The staging system for non-small cell lung cancer (NSCLC) provides a framework for the assessment of pr ... Cite

Complications of thoracoscopic pulmonary resection.

Journal Article Semin Thorac Cardiovasc Surg · 2007 Thoracoscopic strategies are becoming increasingly utilized in the management of patients with thoracic disease processes, including primary pulmonary malignancy, secondary pulmonary malignancy, granulomatous lung disease, and pleural processes. Although m ... Full text Link to item Cite

Improved survival with pulmonary metastasectomy: an analysis of 1720 patients with pulmonary metastatic melanoma.

Journal Article J Thorac Cardiovasc Surg · January 2007 OBJECTIVES: The outcomes of patients with metastatic melanoma are poor. Although prognostic models have been developed to predict the occurrence of pulmonary metastasis from cutaneous melanoma, few data exist to define the outcomes of these patients once m ... Full text Link to item Cite

Thoracoscopic lobectomy

Journal Article Journal of Medical Sciences · January 1, 2007 The surgical approach in the management of patients with lung cancer is evolving. Conventional surgical approaches utilizing thoracotomy remain the standard for the majority of patients with resectable lung cancer. Minimally invasive procedures, however, m ... Cite

Invited commentary.

Other Ann Thorac Surg · January 2007 Full text Link to item Cite

Molecular and genetic markers in thoracic surgery.

Journal Article Ann Thorac Surg · December 2006 Full text Link to item Cite

Molecular biologic staging of esophageal cancer.

Journal Article Thorac Surg Clin · November 2006 The molecular biology of esophageal cancer is characterized by a series of genetic mutations that occur throughout the progression from normal squamous epithelium to carcinoma. The most important risk factor for the development of adenocarcinoma, which is ... Full text Link to item Cite

Suitability of the lumbar test dose for the thoracic epidural space.

Journal Article J Cardiothorac Vasc Anesth · October 2006 Full text Link to item Cite

Nine-year single center experience with cervical mediastinoscopy: complications and false negative rate.

Journal Article Ann Thorac Surg · October 2006 BACKGROUND: Mediastinoscopy is a valuable tool for evaluating mediastinal pathology and is essential for establishing treatment strategies in most patients with lung cancer. We sought to determine the complication and false negative rate for mediastinoscop ... Full text Link to item Cite

Thoracoscopic lobectomy: evolving and improving.

Journal Article J Thorac Cardiovasc Surg · September 2006 Full text Link to item Cite

Thoracoscopic lobectomy is a safe and versatile procedure: experience with 500 consecutive patients.

Journal Article Ann Surg · September 2006 OBJECTIVE: Advantages of thoracoscopic lobectomy for early stage non-small cell lung cancer (NSCLC), as compared with lobectomy by conventional thoracotomy, include less postoperative pain and shorter length of hospitalization. The outcomes after thoracosc ... Full text Link to item Cite

Thoracoscopic lobectomy: a safe and effective strategy for patients receiving induction therapy for non-small cell lung cancer.

Journal Article Ann Thorac Surg · July 2006 BACKGROUND: Thoracoscopic lobectomy is an accepted oncologic approach for early stage non-small cell lung cancer (NSCLC). We conducted a retrospective study of patients who underwent lobectomy after induction therapy to determine the feasibility of thoraco ... Full text Link to item Cite

A phase I study of capecitabine (CAP), carboplatin (CARB), paclitaxel (TAX) and external beam radiation therapy (EBRT) for patients with esophageal carcinoma (EC).

Journal Article J Clin Oncol · June 20, 2006 14044 Background: Chemoradiotherapy is used to treat esophageal cancer with curative intent or local symptom control. A phase I study of 5-FU + CARB + TAX + EBRT showed 100% RR and 50% pCR rate. CAP allows for fluoropyrimidine treatment without the inconve ... Link to item Cite

Serum protein expression predicts recurrence in patients with early-stage lung cancer after resection.

Journal Article Ann Thorac Surg · June 2006 BACKGROUND: Patients with early stage nonsmall-cell lung cancer who have undergone complete resection have a recurrence rate of approximately 50%, predominately due to the development of systemic metastases. This study is a prospective analysis of the expr ... Full text Link to item Cite

Efficacy of single-dose, multilevel paravertebral nerve blockade for analgesia after thoracoscopic procedures.

Journal Article Anesthesiology · May 2006 BACKGROUND: Although video-assisted thoracoscopic surgery for pulmonary resection is increasingly chosen over thoracotomy, the optimal analgesia regimen for thoracoscopy is unknown. The purpose of this trial was to compare the efficacy of analgesia from pr ... Full text Link to item Cite

Pathologic nodal status predicts disease-free survival after neoadjuvant chemoradiation for gastroesophageal junction carcinoma.

Journal Article Ann Surg Oncol · March 2006 BACKGROUND: The incidence of carcinoma of the gastroesophageal junction (GEJ) is rapidly increasing, and the prognosis remains poor. We examined outcomes in patients who received neoadjuvant chemoradiation for GEJ tumors to identify factors that predict di ... Full text Link to item Cite

Invited commentary.

Other Ann Thorac Surg · March 2006 Full text Link to item Cite

Respiratory complications after esophagectomy.

Journal Article Thorac Surg Clin · February 2006 Pulmonary complications are the major source of morbidity and mortality after esophageal resection, and numerous studies have identified various associated with these complications. This article discusses preoperative, intraoperative, and postoperative fac ... Full text Link to item Cite

Preface

Other Thoracic Surgery Clinics · January 1, 2006 Full text Cite

Extended surgical staging for potentially resectable malignant pleural mesothelioma.

Other Ann Thorac Surg · December 2005 BACKGROUND: Extrapleural pneumonectomy for malignant pleural mesothelioma (MPM) is a high-risk procedure, and patients require careful preoperative staging to exclude advanced disease. Computed tomography, magnetic resonance imaging, and positron emission ... Full text Link to item Cite

Outcomes of tracheobronchial stents in patients with malignant airway disease.

Journal Article Ann Thorac Surg · August 2005 BACKGROUND: Malignant central airway obstruction is difficult to manage and is associated with poor outcome. We sought to identify the short (< 30 days) and intermediate (> 30 days) benefits and risks of tracheobronchial stents in patients with malignant a ... Full text Link to item Cite

Low morbidity and mortality for bronchoplastic procedures with and without induction therapy.

Journal Article Ann Thorac Surg · August 2005 BACKGROUND: The safety of bronchoplastic procedures after induction chemoradiotherapy is uncertain. This study examines short- and long-term outcomes after bronchoplastic procedures with and without induction therapy. METHODS: Between January 1997 and Sept ... Full text Link to item Cite

"Anatomically-correct" dosimetric parameters may be better predictors for esophageal toxicity than are traditional CT-based metrics.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2005 PURPOSE: Incidental esophageal irradiation during lung cancer therapy often causes morbidity. There is interest in trying to relate esophageal dosimetric parameters to the risk of injury. These parameters typically rely on CT-defined esophageal contours, a ... Full text Link to item Cite

The impact of pre-radiotherapy surgery on radiation-induced lung injury.

Journal Article Clin Oncol (R Coll Radiol) · June 2005 AIMS: The use of postoperative radiation therapy (PORT) is predicated by an assessment of the potential benefits and risks, including radiation-induced lung injury. In this study, the risk of radiation-induced lung injury is assessed in patients who receiv ... Full text Link to item Cite

Troubleshooting video-assisted thoracic surgery lobectomy.

Journal Article Ann Thorac Surg · May 2005 PURPOSE: Surgeons converting their open lobectomy skills to video-assisted thoracic surgery (VATS) techniques have sought traditional technical courses, publications, and physician mentoring. While these are useful in teaching basic principles, it is more ... Full text Link to item Cite

Adjuvant chemotherapy for non-small cell lung cancer.

Journal Article Semin Thorac Cardiovasc Surg · 2005 The survival after complete resection for non-small cell lung cancer (NSCLC) is unsatisfactory. Until recently, the use of adjuvant therapy after resection for early stage disease has not been proven to improve survival. However, the efficacy of adjuvant t ... Full text Link to item Cite

Molecular staging and the selection of therapy for non-small cell lung cancer.

Journal Article Semin Thorac Cardiovasc Surg · 2005 The stage-specific selection of therapy is the standard for patients with non-small cell lung cancer. Investigation of the molecular biology of lung cancer has provided pathways and targets that may be used to improve the efficacy of therapy and improve th ... Full text Link to item Cite

Controversial issues regarding the use of induction chemotherapy for lung cancer.

Journal Article Semin Thorac Cardiovasc Surg · 2005 Induction chemotherapy has been proven to improve survival in patients with Stage IIIA non-small cell lung cancer, and is under investigation for early stage disease. Controversy still exists regarding the choice of chemotherapy regimens, patient selection ... Full text Link to item Cite

Targeted therapy for non-small cell lung cancer.

Journal Article Semin Thorac Cardiovasc Surg · 2005 The overall survival for the treatment of lung cancer patients is less than 15%, despite advances in chemotherapy, radiation therapy, and surgery, due to the inability to control metastatic disease. Over the past three decades, the genetics of lung cancer ... Full text Link to item Cite

Acute lung injury and acute respiratory distress syndrome after pulmonary resection.

Journal Article Semin Cardiothorac Vasc Anesth · December 2004 The occurrence of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) after thoracic surgery are perplexing and persistent problems. Variously described as postpneumonectomy pulmonary edema, noncardiogenic pulmonary edema, and postlung r ... Full text Link to item Cite

Mediastinal tumor

Chapter · October 1, 2004 Full text Cite

Reducing hospital morbidity and mortality following esophagectomy.

Journal Article Ann Thorac Surg · October 2004 BACKGROUND: Esophagogastrectomy (EG) is a formidable operation with significant morbidity and mortality rates. Risk factor analyses have been performed, but few studies have produced strategies that have improved operative results. This study was performed ... Full text Link to item Cite

Expression profiling of non-small cell lung carcinoma identifies metastatic genotypes based on lymph node tumor burden.

Journal Article J Thorac Cardiovasc Surg · May 2004 OBJECTIVE: This study hypothesized that non-small cell lung carcinoma cells from primary tumors isolated by laser capture microdissection would exhibit gene expression profiles associated with graded lymph node metastatic cell burden. METHODS: Non-small ce ... Full text Link to item Cite

Angiogenesis in non-small cell lung cancer.

Journal Article Semin Thorac Cardiovasc Surg · 2004 Two processes are necessary for a tumor colony to grow and become invasive: angiogenesis and basement membrane degradation. Angiogenesis is the formation of new blood vessels from the endothelium of existing vasculature, in response to the metabolic demand ... Full text Link to item Cite

Thoracoscopic lobectomy

Journal Article Operative Techniques in Thoracic and Cardiovascular Surgery · January 1, 2004 Minimally invasive approaches to lung cancer treatment have been demonstrated to be safe and effective for patients with early-stage lung cancer. Thoracoscopic lobectomy is designed to achieve the same oncologic result as conventional lobectomy: Complete h ... Full text Cite

Cerebral embolization during cardiac surgery: impact of aortic atheroma burden.

Other Br J Anaesth · November 2003 BACKGROUND: Aortic atheromatous disease is known to be associated with an increased risk of perioperative stroke in the setting of cardiac surgery. In this study, we sought to determine the relationship between cerebral microemboli and aortic atheroma burd ... Full text Link to item Cite

Home surveillance program prevents interstage mortality after the Norwood procedure.

Journal Article J Thorac Cardiovasc Surg · November 2003 OBJECTIVE: To determine whether early identification of physiologic variances associated with interstage death would reduce mortality, we developed a home surveillance program. METHODS: Patients discharged before initiation of home surveillance (group A, n ... Full text Link to item Cite

Measurement of chemoresistance markers in patients with stage III non-small cell lung cancer: a novel approach for patient selection.

Journal Article Ann Thorac Surg · July 2003 BACKGROUND: The long-term survival of patients with stage III non-small cell lung cancer treated with a combination of chemotherapy and radiation is 10% to 20%. Survival could potentially be increased and toxicity limited if one could identify patients mos ... Full text Link to item Cite

Local control without resection.

Journal Article J Thorac Cardiovasc Surg · April 2003 Full text Link to item Cite

Gastric cancer. Clinical practice guidelines in oncology.

Journal Article J Natl Compr Canc Netw · January 2003 Gastric cancer is rampant in several countries around the world. Its incidence in the West has been on the decline for more than 40 years; however, the location of gastric cancer has shifted proximally in the past 15 years. The reason for this shift is not ... Full text Link to item Cite

Esophageal cancer. Clinical practice guidelines in oncology.

Journal Article J Natl Compr Canc Netw · January 2003 Esophageal cancer is a major health hazard in many parts of the world. The incidence of adenocarcinoma is rising in white men, particularly in the nonendemic areas, such as the West. Barrett's metaplasia, gastroesophageal reflux, hiatal hernia, and obesity ... Full text Link to item Cite

Thoracoscopic lobectomy: a safe and effective strategy for patients with stage I lung cancer.

Journal Article Ann Thorac Surg · September 2002 Featured Publication BACKGROUND: Thoracoscopic lobectomy is emerging as a potential alternative to thoracotomy for early stage lung cancer. The issues of safety and oncologic efficacy should be analyzed before recommending this procedure for widespread use. METHODS: Thoracosco ... Full text Link to item Cite

Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction.

Other Anesth Analg · July 2002 UNLABELLED: Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, ... Full text Link to item Cite

Impact of computed tomography-positron emission tomography fusion in staging patients with thoracic malignancies.

Journal Article Ann Thorac Surg · July 2002 Featured Publication BACKGROUND: Positron emission tomography (PET) has been demonstrated to improve staging in patients with thoracic malignancies. This study evaluates the ability of a new imaging technique to improve the spatial resolution and accuracy of PET. METHODS: Pati ... Full text Link to item Cite

Molecular staging of lung and esophageal cancer.

Journal Article Surg Clin North Am · June 2002 Featured Publication In both esophageal and NSCLC, the TNM stage at diagnosis remains the most important determinant of survival. Significant research to investigate the biology of NSCLC and esophageal carcinoma is ongoing, and the roles of proto-oncogenes, tumor suppressor ge ... Full text Link to item Cite

Molecular biologic substaging of non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · March 2002 Featured Publication Full text Link to item Cite

The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery.

Other Anesth Analg · January 2002 UNLABELLED: Neurocognitive dysfunction is a common complication after cardiac surgery. We evaluated in this prospective study the effect of rewarming rate on neurocognitive outcome after hypothermic cardiopulmonary bypass (CPB). After IRB approval and info ... Full text Link to item Cite

Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy.

Journal Article AIDS Res Hum Retroviruses · November 20, 2001 Featured Publication The thymus of HIV-seropositive patients can enlarge as CD4+ T cell counts increase on highly active anti-retroviral therapy (HAART). This may indicate development of new T cells or represent mature peripheral T cells recirculating to the thymus. To define ... Full text Link to item Cite

Predicting the sites of metastases from lung cancer using molecular biologic markers.

Journal Article Ann Thorac Surg · October 2001 Featured Publication BACKGROUND: The use of molecular markers in staging non-small cell lung cancer (NSCLC) has been supported in retrospective prognostic models but has not been evaluated in predicting sites of metastases. METHODS: Pathologic specimens were collected from 202 ... Full text Link to item Cite

Tumor marker expression is predictive of survival in patients with esophageal cancer.

Journal Article Ann Thorac Surg · September 2001 Featured Publication BACKGROUND: This study was designed to determine the prognostic value of immunohistochemical tumor marker expression in a population of patients with node-negative esophageal cancer treated with complete resection alone. METHODS: Resection specimens were c ... Full text Link to item Cite

The prognostic value of molecular marker analysis in patients treated with trimodality therapy for esophageal cancer.

Journal Article Clin Cancer Res · March 2001 Featured Publication The purpose of this study was to define the prognostic value of a group of molecular tumor markers in a well-staged population of patients treated with trimodality therapy for esophageal cancer. The original pretreatment paraffin-embedded endoscopic esopha ... Link to item Cite

Molecular biology of esophageal cancer.

Journal Article Chest Surg Clin N Am · August 2000 Featured Publication Several mechanisms of resistance to chemotherapy have been identified among the agents that are commonly used in the systemic treatment of patients with esophageal cancer: paclitaxel, platinum, and 5-FU. A recent study from our laboratory evaluated the ini ... Link to item Cite

Myxoid liposarcoma of the supraclavicular fossa.

Journal Article Chest · May 2000 Featured Publication Liposarcomas generally originate most often in the extremities or retroperitoneum, less frequently in the head and neck, and rarely in the thorax. We describe a particularly rare presentation of myxoid liposarcoma originating in the supraclavicular fossa. ... Full text Link to item Cite

Influence of panel-reactive antibodies on posttransplant outcomes in lung transplant recipients.

Journal Article Ann Thorac Surg · May 2000 Featured Publication BACKGROUND: Panel-reactive antibody (PRA) is used to estimate the degree of humoral sensitization in the recipient before transplantation. Although pretransplant sensitization is associated with increased complications in other solid organ transplant recip ... Full text Link to item Cite

Molecular biologic substaging of stage I lung cancer according to gender and histology.

Journal Article Ann Thorac Surg · March 2000 Featured Publication BACKGROUND: This study is designed to assess molecular biologic substaging according to gender and histology in patients with stage I non-small cell lung cancer (NSCLC). METHODS: Pathologic specimens were collected from 408 consecutive patients after compl ... Full text Link to item Cite

Gene therapy for lung cancer.

Journal Article Clin Lung Cancer · February 2000 Gene therapy is emerging as a promising modality for the treatment of lung cancer. Diverse strategies employing gene therapy for lung cancer have been investigated in vitro and in animal models, and a number of these approaches have met with promising resu ... Full text Link to item Cite

Cognitive decline after major noncardiac operations: a preliminary prospective study.

Journal Article Ann Thorac Surg · November 1999 BACKGROUND: Cardiac operations frequently are complicated by postoperative cognitive decline. Less common and less studied is postoperative cognitive decline after noncardiac surgery, so we determined its incidence, severity, and possible predictors. METHO ... Full text Link to item Cite

A biologic risk model for stage I lung cancer: immunohistochemical analysis of 408 patients with the use of ten molecular markers.

Journal Article J Thorac Cardiovasc Surg · April 1999 Featured Publication OBJECTIVE: The standard treatment of patients with stage I non-small cell lung cancer is resection of the primary tumor; however, the recurrence rate is 28% to 45%. This study evaluates a panel of molecular markers in a large population of patients with st ... Full text Link to item Cite

Malignant melanoma presenting as a mediastinal mass.

Journal Article Ann Thorac Surg · March 1999 A case of malignant melanoma presenting as a mediastinal mass without an extrathoracic primary is reported. Microscopically the tumor appeared consistent with malignant melanoma, with the presence of focal melanin pigment in large epithelioid cells. Fontan ... Full text Link to item Cite

Outcomes of lung transplant recipients with respiratory failure requiring mechanical ventilation

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · March 1, 1999 Link to item Cite

Right Upper Lobe Sleeve Resection

Journal Article Operative Techniques in Thoracic and Cardiovascular Surgery · August 1, 1998 Full text Cite

Lung transplantation at Duke University Medical Center.

Journal Article Clin Transpl · 1998 Lung transplantation is a viable therapy for patients with a variety of end-stage lung diseases. Our active program now includes over 200 lung transplant operations with acceptable one- and 3-year survival rates of 78% and 61%. A major focus of clinical re ... Link to item Cite

Desensitization of myocardial beta-adrenergic receptors and deterioration of left ventricular function after brain death.

Journal Article J Thorac Cardiovasc Surg · September 1995 Brain death often results in a series of hemodynamic alterations that complicate the treatment of potential organ donors before transplantation. The deterioration of myocardial performance after brain death has been described; however, the pathophysiologic ... Full text Link to item Cite

Stability of the beta-adrenergic receptor/adenylyl cyclase pathway of pediatric myocardium after brain death.

Journal Article J Heart Lung Transplant · 1994 Our previous work in the adult porcine model shows that brain death results in a rapid decline in left ventricular systolic function as measured by the preload recruitable stroke work method to 8% of the baseline slope within 6 hours; this process is accom ... Link to item Cite

Improved tolerance of the pediatric myocardium to brain death

Journal Article Journal of Heart and Lung Transplantation · December 1, 1993 The occurrence of brain death has been shown to significantly diminish left ventricular function in the adult porcine model. This study examined whether the pediatric myocardium is as sensitive as the adult myocardium to the detrimental effects of brain de ... Cite

The efficiency of pulmonary blood transport following single lung transplantation.

Journal Article J Surg Res · April 1993 Perioperative right ventricular (RV) dysfunction remains a significant problem following single lung transplantation (SLT), especially in patients with pulmonary hypertension. Total RV power (Wt), a determinant of RV function, is the sum of the mean compon ... Full text Link to item Cite

Effects of triiodothyronine and vasopressin on cardiac function and myocardial blood flow after brain death.

Journal Article J Heart Lung Transplant · 1993 Previous studies have documented decreases in serum-free triiodothyronine (T3) after brain death and improved hemodynamics with its replacement, suggesting its controversial, but promising, clinical utility for managing potential organ donors. Vasopressin ... Link to item Cite

Improved tolerance of the pediatric myocardium to brain death.

Journal Article J Heart Lung Transplant · 1993 The occurrence of brain death has been shown to significantly diminish left ventricular function in the adult porcine model. This study examined whether the pediatric myocardium is as sensitive as the adult myocardium to the detrimental effects of brain de ... Link to item Cite

Effects of triiodothyronine and vasopressin on cardiac function and myocardial blood flow after brain death

Journal Article Journal of Heart and Lung Transplantation · January 1, 1993 Previous studies have documented decreases in serum-free triiodothyronine (T3) after brain death and improved hemodynamics with its replacement, suggesting its controversial, but promising, clinical utility for managing potential organ donors. Vasopressin ... Cite

Pulmonary arterial impedance after single lung transplantation.

Journal Article J Surg Res · May 1992 Single lung transplantation (SLT) is emerging as definitive therapy for end-stage pulmonary disease of varying etiology, yet a complete description of the hemodynamic properties of the transplanted lung has not been reported. In this study, Fourier analysi ... Full text Link to item Cite

Perioperative Outcomes and 5-year Survival After Open versus Thoracoscopic Sleeve Resection for Lung Cancer.

Journal Article Semin Thorac Cardiovasc Surg The objective of this study was to evaluate the impact of a video-assisted thoracoscopic (VATS) approach on outcomes in patients who underwent sleeve lobectomy for non-small-cell lung cancer (NSCLC). Outcomes of patients with cT1-T3, N0-N2, M0 NSCLC who un ... Full text Link to item Cite