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Thomas Michael Price

Professor Emeritus of Obstetrics and Gynecology
Obstetrics and Gynecology, Reproductive Endocrinology & Fertility
Box 3143 Med Ctr, Durham, NC 27710
Duke Fertility Clinic, 5601 Arringdon Park Dr., Ste 210, Morrisville, NC 27560
Office hours M-F 8 am - 5 pm  

Selected Publications


Differential Gene Regulation of the Human Blastocyst Trophectoderm and Inner Cell Mass by Progesterone.

Journal Article Reprod Sci · December 27, 2023 Knowledge of action of progesterone (P4) on the human preimplantation embryo is lacking. The objective of this study was to determine expression of a mitochondrial P4 receptor (PR-M) in the trophectoderm (TE) and the inner cell mass (ICM) of the human blas ... Full text Link to item Cite

Perception of gender disparity in academic reproductive endocrinology and infertility.

Conference Hum Fertil (Camb) · December 2023 The aim of this study was to identify gender differences in leadership/academic rank and attitudes regarding gender representation among academic Reproductive Endocrinology and Infertility subspecialists. Members of the Society of Reproductive Endocrinolog ... Full text Link to item Cite

What predicts durable symptom relief of uterine fibroids treated with MRI-guided focused ultrasound? A multicenter trial in 8 academic centers.

Journal Article Eur Radiol · November 2023 OBJECTIVE: To identify variables predictive of durable clinical success after MRI-guided focused ultrasound (MRgFUS) treatment of uterine fibroids. MATERIALS AND METHODS: In this prospective, multicenter trial, 99 women with symptomatic uterine fibroids we ... Full text Link to item Cite

Reproductive Functions of the Mitochondrial Progesterone Receptor (PR-M).

Journal Article Reprod Sci · May 2023 Classic transcriptional regulation by progesterone via the nuclear progesterone receptors A and B (PR-A, PR-B) has been recognized for decades. Less attention has been given to a mitochondrial progesterone receptor (PR-M) responsible for non-nuclear activi ... Full text Link to item Cite

Direct-to-consumer fertility testing: utilization and perceived utility among fertility patients and reproductive endocrinologists.

Journal Article Reprod Biomed Online · March 2023 RESEARCH QUESTION: What is the utilization of direct-to-consumer fertility tests (DTCFT) among fertility patients? How does the perceived utility of DTCFT differ between patients and reproductive endocrinologists (REI)? DESIGN: Infertility patients visitin ... Full text Link to item Cite

Postoperative Acute Kidney Injury by Age and Sex: A Retrospective Cohort Association Study.

Journal Article Anesthesiology · February 1, 2023 BACKGROUND: Acute kidney injury (AKI) after noncardiac surgery is common and has substantial health impact. Preclinical and clinical studies examining the influence of sex on AKI have yielded conflicting results, although they typically do not account for ... Full text Link to item Cite

Human Chorionic Gonadotropin-A Review of the Literature.

Journal Article Obstet Gynecol Surv · September 2022 IMPORTANCE: The measurement of human chorionic gonadotropin (hCG) levels in different body fluids is a commonly utilized tool in obstetrics and gynecology, as well as other fields. It is often one of the first steps in the medical workup of female patients ... Full text Link to item Cite

Fibroids and Fertility: A Comparison of Myomectomy and Uterine Artery Embolization on Fertility and Reproductive Outcomes.

Journal Article Obstet Gynecol Surv · August 2022 IMPORTANCE: Leiomyomata, or fibroids, are a common gynecological problem affecting many women of reproductive age. Historically, myomectomy is offered to women with symptomatic fibroids who desire to preserve fertility. More recently, uterine artery emboli ... Full text Link to item Cite

Male obesity impacts DNA methylation reprogramming in sperm.

Journal Article Clin Epigenetics · January 25, 2021 BACKGROUND: Male obesity has profound effects on morbidity and mortality, but relatively little is known about the impact of obesity on gametes and the potential for adverse effects of male obesity to be passed to the next generation. DNA methylation contr ... Full text Open Access Link to item Cite

Opposing Epigenetic Signatures in Human Sperm by Intake of Fast Food Versus Healthy Food.

Journal Article Front Endocrinol (Lausanne) · 2021 Animal experiments have demonstrated that diets high in fats create a harmful environment for developing sperm cells, contributing to impaired reproductive health and induced risk for chronic diseases in the next generation. Changes at the level of the epi ... Full text Link to item Cite

Refraining from use diminishes cannabis-associated epigenetic changes in human sperm.

Journal Article Environ Epigenet · 2021 Cannabis use alters sperm DNA methylation, but the potential reversibility of these changes is unknown. Semen samples from cannabis users and non-user controls were collected at baseline and again following a 77-day period of cannabis abstinence (one sperm ... Full text Open Access Link to item Cite

Fertilization and embryogenesis

Chapter · January 1, 2021 This chapter takes the reader through the earliest stages of reproduction, including gamete formation, fertilization with embryo development, and development of the urogenital system. The chapter has been updated to describe the role of assisted reproducti ... Full text Cite

Preimplantation genetic testing: a review of current modalities

Journal Article F and S Reviews · January 1, 2021 In this review, we evaluate the different modalities of embryo genetic testing including preimplantation genetic testing for aneuploidy (PGT-A), for monogenic/single-gene abnormalities (PGT-M), and for chromosomal structural rearrangements (PGT-SR), with a ... Full text Cite

Data from: Cannabinoid exposure and altered DNA methylation in rat and human sperm

Dataset · August 25, 2020 This dataset contains the raw sequencing data files for reduced representation bisulfite sequencing. Abstract: Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol ... Full text Cite

Differential Gene Regulation of the Human Blastocyst Trophectoderm and Inner Cell Mass by Progesterone.

Journal Article Reprod Sci · December 27, 2023 Knowledge of action of progesterone (P4) on the human preimplantation embryo is lacking. The objective of this study was to determine expression of a mitochondrial P4 receptor (PR-M) in the trophectoderm (TE) and the inner cell mass (ICM) of the human blas ... Full text Link to item Cite

Perception of gender disparity in academic reproductive endocrinology and infertility.

Conference Hum Fertil (Camb) · December 2023 The aim of this study was to identify gender differences in leadership/academic rank and attitudes regarding gender representation among academic Reproductive Endocrinology and Infertility subspecialists. Members of the Society of Reproductive Endocrinolog ... Full text Link to item Cite

What predicts durable symptom relief of uterine fibroids treated with MRI-guided focused ultrasound? A multicenter trial in 8 academic centers.

Journal Article Eur Radiol · November 2023 OBJECTIVE: To identify variables predictive of durable clinical success after MRI-guided focused ultrasound (MRgFUS) treatment of uterine fibroids. MATERIALS AND METHODS: In this prospective, multicenter trial, 99 women with symptomatic uterine fibroids we ... Full text Link to item Cite

Reproductive Functions of the Mitochondrial Progesterone Receptor (PR-M).

Journal Article Reprod Sci · May 2023 Classic transcriptional regulation by progesterone via the nuclear progesterone receptors A and B (PR-A, PR-B) has been recognized for decades. Less attention has been given to a mitochondrial progesterone receptor (PR-M) responsible for non-nuclear activi ... Full text Link to item Cite

Direct-to-consumer fertility testing: utilization and perceived utility among fertility patients and reproductive endocrinologists.

Journal Article Reprod Biomed Online · March 2023 RESEARCH QUESTION: What is the utilization of direct-to-consumer fertility tests (DTCFT) among fertility patients? How does the perceived utility of DTCFT differ between patients and reproductive endocrinologists (REI)? DESIGN: Infertility patients visitin ... Full text Link to item Cite

Postoperative Acute Kidney Injury by Age and Sex: A Retrospective Cohort Association Study.

Journal Article Anesthesiology · February 1, 2023 BACKGROUND: Acute kidney injury (AKI) after noncardiac surgery is common and has substantial health impact. Preclinical and clinical studies examining the influence of sex on AKI have yielded conflicting results, although they typically do not account for ... Full text Link to item Cite

Human Chorionic Gonadotropin-A Review of the Literature.

Journal Article Obstet Gynecol Surv · September 2022 IMPORTANCE: The measurement of human chorionic gonadotropin (hCG) levels in different body fluids is a commonly utilized tool in obstetrics and gynecology, as well as other fields. It is often one of the first steps in the medical workup of female patients ... Full text Link to item Cite

Fibroids and Fertility: A Comparison of Myomectomy and Uterine Artery Embolization on Fertility and Reproductive Outcomes.

Journal Article Obstet Gynecol Surv · August 2022 IMPORTANCE: Leiomyomata, or fibroids, are a common gynecological problem affecting many women of reproductive age. Historically, myomectomy is offered to women with symptomatic fibroids who desire to preserve fertility. More recently, uterine artery emboli ... Full text Link to item Cite

Male obesity impacts DNA methylation reprogramming in sperm.

Journal Article Clin Epigenetics · January 25, 2021 BACKGROUND: Male obesity has profound effects on morbidity and mortality, but relatively little is known about the impact of obesity on gametes and the potential for adverse effects of male obesity to be passed to the next generation. DNA methylation contr ... Full text Open Access Link to item Cite

Opposing Epigenetic Signatures in Human Sperm by Intake of Fast Food Versus Healthy Food.

Journal Article Front Endocrinol (Lausanne) · 2021 Animal experiments have demonstrated that diets high in fats create a harmful environment for developing sperm cells, contributing to impaired reproductive health and induced risk for chronic diseases in the next generation. Changes at the level of the epi ... Full text Link to item Cite

Refraining from use diminishes cannabis-associated epigenetic changes in human sperm.

Journal Article Environ Epigenet · 2021 Cannabis use alters sperm DNA methylation, but the potential reversibility of these changes is unknown. Semen samples from cannabis users and non-user controls were collected at baseline and again following a 77-day period of cannabis abstinence (one sperm ... Full text Open Access Link to item Cite

Fertilization and embryogenesis

Chapter · January 1, 2021 This chapter takes the reader through the earliest stages of reproduction, including gamete formation, fertilization with embryo development, and development of the urogenital system. The chapter has been updated to describe the role of assisted reproducti ... Full text Cite

Preimplantation genetic testing: a review of current modalities

Journal Article F and S Reviews · January 1, 2021 In this review, we evaluate the different modalities of embryo genetic testing including preimplantation genetic testing for aneuploidy (PGT-A), for monogenic/single-gene abnormalities (PGT-M), and for chromosomal structural rearrangements (PGT-SR), with a ... Full text Cite

Data from: Cannabinoid exposure and altered DNA methylation in rat and human sperm

Dataset · August 25, 2020 This dataset contains the raw sequencing data files for reduced representation bisulfite sequencing. Abstract: Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol ... Full text Cite

Progesterone Increases Mitochondria Membrane Potential in Non-human Primate Oocytes and Embryos.

Journal Article Reprod Sci · May 2020 Mitochondrial activity is critical and correlates with embryo development. The identification of a novel human mitochondrial progesterone receptor (PR-M) that increases cellular respiration brings into question a role for progesterone in oocyte and preimpl ... Full text Link to item Cite

Academic pursuits in board-certified reproductive endocrinologists.

Journal Article Fertil Steril · March 2020 OBJECTIVE: To determine research interests of reproductive endocrinology and infertility (REI) physicians and assess their academic productivity. DESIGN: A questionnaire composed by the Society for REI (SREI) board members was e-mailed to members. PubMed w ... Full text Link to item Cite

Hormonal management of menopausal symptoms in women with a history of gynecologic malignancy.

Journal Article Menopause · February 2020 OBJECTIVE: The aim of the study was to review the role of hormone therapy in menopausal patients with breast cancer and gynecologic malignancies. METHODS: We searched MEDLINE (via PubMed) using a combination of keywords and database-specific subject headin ... Full text Open Access Link to item Cite

Comparison of traditional and step up protocols with letrozole

Conference Fertility and Sterility · September 2019 Full text Cite

Diagnosis of Cushing Syndrome during an Infertility Evaluation.

Journal Article Ann Clin Case Rep · June 3, 2019 Cite

FIRSTT study: randomized controlled trial of uterine artery embolization vs focused ultrasound surgery.

Journal Article Am J Obstet Gynecol · February 2019 BACKGROUND: Uterine leiomyomas (fibroid tumors) cause considerable symptoms in 30-50% of women and are the leading cause of hysterectomy in the United States. Women with uterine fibroid tumors often seek uterine-preserving treatments, but comparative effec ... Full text Link to item Cite

A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling.

Journal Article J Endocr Soc · February 1, 2019 Progesterone is primarily a pregnancy-related hormone, produced in substantial quantities after ovulation and during gestation. Traditionally known to function via nuclear receptors for transcriptional regulation, there is also evidence of nonnuclear actio ... Full text Open Access Link to item Cite

Academic pursuits in board certified reproductive endocrinologists

Conference Fertility and Sterility · September 2018 Full text Cite

Cannabinoid exposure and altered DNA methylation in rat and human sperm.

Journal Article Epigenetics · 2018 Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA methylation in sperm from humans and rats, respectively. DNA methylation, measur ... Full text Open Access Link to item Cite

Importance of research for reproductive endocrinologists

Conference Fertility and Sterility · September 2017 Full text Cite

Periprocedural outcomes comparing fibroid embolization and focused ultrasound: a randomized controlled trial and comprehensive cohort analysis.

Journal Article Am J Obstet Gynecol · May 2017 BACKGROUND: Uterine fibroids are a common problem for reproductive-aged women, yet little comparative effectiveness research is available to guide treatment choice. Uterine artery embolization and magnetic resonance imaging-guided focused ultrasound surger ... Full text Link to item Cite

Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States.

Journal Article Environ Sci Technol Lett · March 14, 2017 During the past decade, use of organophosphate compounds as flame retardants and plasticizers has increased. Numerous studies investigating biomarkers (i.e., urinary metabolites) demonstrate ubiquitous human exposure and suggest that human exposure may be ... Full text Link to item Cite

Human exposure to flame-retardants is associated with aberrant DNA methylation at imprinted genes in sperm.

Journal Article Environ Epigenet · January 2017 Emerging evidence suggests that early exposure to endocrine disrupting chemicals has long-term consequences that can influence disease risk in offspring. During gametogenesis, imprinted genes are reasonable epigenetic targets with the ability to retain and ... Full text Link to item Cite

Challenges Diagnosing Appendiceal Neoplasms during Pregnancy

Journal Article Obstetrics and Gynaecology Cases - Reviews · December 31, 2016 Full text Cite

Fibroid interventions: reducing symptoms today and tomorrow: extending generalizability by using a comprehensive cohort design with a randomized controlled trial.

Journal Article Am J Obstet Gynecol · September 2016 BACKGROUND: Uterine fibroids are an important source of morbidity for reproductive-aged women. Despite an increasing number of alternatives, hysterectomies account for about 75% of all fibroid interventional treatments. Evidence is lacking to help women an ... Full text Link to item Cite

Environmental Influence on Preconceptional and Gestational DNA Methylation Profiles.

Conference ENVIRONMENTAL AND MOLECULAR MUTAGENESIS · September 1, 2016 Link to item Cite

The effect of progesterone on early embryo metabolism

Conference Fertility and Sterility · September 2016 Full text Cite

Practice patterns, satisfaction, and demographics of reproductive endocrinologists: results of the 2014 Society for Reproductive Endocrinology and Infertility Workforce Survey.

Journal Article Fertil Steril · May 2016 OBJECTIVE: To identify the current and future state of the practice of reproductive medicine. DESIGN: Cross-sectional survey. SETTING: Not applicable. PATIENT(S): None. INTERVENTION(S): Not applicable. MAIN OUTCOME MEASURE(S): The survey included 57 questi ... Full text Link to item Cite

The impact of short-term depot-medroxyprogesterone acetate treatment on resting metabolic rate.

Journal Article Contraception · April 2016 OBJECTIVE: This study examines the effect of a progestogen (depot-medroxyprogesterone acetate, DMPA) on resting metabolic rate (RMR) in a cohort of young, normal-weight healthy women. We hypothesize an increase in RMR and nonshivering thermogenesis (NST) r ... Full text Link to item Cite

High peak estradiol/mature oocyte ratio predicts lower clinical pregnancy, ongoing pregnancy, and live birth rates in GnRH antagonist intracytoplasmic sperm injection cycles

Journal Article Journal of Reproductive Medicine · February 1, 2016 OBJECTIVE: To define the relationship between peak estradiol (E2)/mature oocyte ratio and pregnancy outcomes in gonadotropin-releasing hormone (GnRH) antagonist intracytoplasmic sperm injection (ICSI) cycles. STUDY DESIGN: Retrospective cohort study in the ... Cite

High Peak Estradiol/Mature Oocyte Ratio Predicts Lower Clinical Pregnancy, Ongoing Pregnancy, and Live Birth Rates in GnRH Antagonist Intracytoplasmic Sperm Injection Cycles.

Journal Article J Reprod Med · 2016 OBJECTIVE: To define the relationship between peak estradiol (E2)/mature oocyte ratio and pregnancy outcomes in gonadotropin-releasing hormone (GnRH) antagonist intracytoplasmic sperm injection (ICSI) cycles. STUDY DESIGN: Retrospective cohort study in the ... Link to item Cite

Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study.

Journal Article Clin Epigenetics · 2016 BACKGROUND: Epigenetic reprogramming in mammalian gametes resets methylation marks that regulate monoallelic expression of imprinted genes. In males, this involves erasure of the maternal methylation marks and establishment of paternal-specific methylation ... Full text Link to item Cite

High peak estradiol predicts higher miscarriage and lower live birth rates in high responders triggered with a gnrh agonist in IVF/ICSI cycles

Journal Article Journal of Reproductive Medicine · December 1, 2015 OBJECTIVE: To investigate parameters predictive of pregnancy outcomes in high responders undergoing fresh, autologous, GnRH antagonist IVF/ICSI cycles using a GnRH agonist trigger. STUDY DESIGN: Retrospective cohort study of all patients deemed high-risk f ... Cite

Who are we? The 2014 SREI work force study

Conference Fertility and Sterility · September 2015 Full text Cite

The Role of a Mitochondrial Progesterone Receptor (PR-M) in Progesterone Action.

Journal Article Semin Reprod Med · May 2015 Historically, progesterone functions to regulate gene expression via two nuclear progesterone receptors (PR-B and PR-A). Yet, actions of progesterone independent of gene regulation have been observed for decades. These are based on progesterone induced cel ... Full text Link to item Cite

An Update on Surgical versus Expectant Management of Ovarian Endometriomas in Infertile Women.

Journal Article Biomed Res Int · 2015 Ovarian endometriomas are a common manifestation of endometriosis that can represent a more severe stage of the disease. There is much debate over the treatment of these cysts in infertile women, particularly before use of assisted reproductive technologie ... Full text Open Access Link to item Cite

High Peak Estradiol Predicts Higher Miscarriage and Lower Live Birth Rates in High Responders Triggered with a GnRH Agonist in IVF/ICSI Cycles.

Journal Article J Reprod Med · 2015 OBJECTIVE: To investigate parameters predictive of pregnancy outcomes in high responders undergoing fresh, autologous, GnRH antagonist IVF/ICSI cycles using a GnRH agonist trigger. STUDY DESIGN: Retrospective cohort study of all patients deemed high-risk f ... Link to item Cite

Expression of a mitochondrial progesterone receptor in human spermatozoa correlates with a progestin-dependent increase in mitochondrial membrane potential.

Journal Article Andrology · November 2014 The hyperactivation of human spermatozoa necessary for fertilization requires a substantial increase in cellular energy production. The factors responsible for increasing cellular energy remain poorly defined. This article proposes a role for a novel mitoc ... Full text Link to item Cite

Oocyte number as a predictor for ovarian hyperstimulation syndrome and live birth: an analysis of 256,381 in vitro fertilization cycles.

Journal Article Fertil Steril · April 2014 OBJECTIVE: To investigate the association between oocyte number and the rates of ovarian hyperstimulation syndrome (OHSS) and live birth (LB) in fresh autologous in vitro fertilization (IVF) cycles. DESIGN: Retrospective cohort study. SETTING: An academic ... Full text Link to item Cite

Expression of a mitochondrial progesterone receptor (PR-M) in leiomyomata and association with increased mitochondrial membrane potential.

Journal Article J Clin Endocrinol Metab · March 2014 CONTEXT: Clinical evidence supports a role for progestins in the growth of leiomyomata (fibroids). The mechanism(s) for this is thought to involve gene regulation via the nuclear progesterone receptors. Recently a mitochondrial progesterone receptor (PR-M) ... Full text Link to item Cite

A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration.

Journal Article Mol Endocrinol · May 2013 The cDNA for a novel truncated progesterone receptor (PR-M) was previously cloned from human adipose and aortic cDNA libraries. The predicted protein sequence contains 16 unique N-terminal amino acids, encoded by a sequence in the distal third intron of th ... Full text Link to item Cite

Hyperglycosylated human chorionic gonadotropin does not increase progesterone production by luteinized granulosa cells.

Journal Article J Clin Endocrinol Metab · September 2012 CONTEXT: Trophoblast-derived human chorionic gonadotropin (hCG) promotes corpus luteum progesterone (P4) production, and wide ranges of serum P4 levels are noted in various pregnancy outcomes, despite similar hCG concentrations. There are five unique biolo ... Full text Link to item Cite

The impact of familial Mediterranean fever on women's health.

Journal Article Obstet Gynecol Surv · June 2012 Familial Mediterranean fever (FMF) is the most common hereditary recurrent febrile disorder, characterized by the sudden onset of high fever and severe abdominal pain. The implications of this disorder on a woman's health are significant and not well known ... Full text Link to item Cite

Management of gynecologic surgery in the patient with factor XI deficiency: a review of the literature.

Journal Article Obstet Gynecol Surv · May 2012 UNLABELLED: Factor XI deficiency is a rare bleeding disorder that is more commonly found in Ashkenazi Jews. Bleeding manifestations of this disorder are varied and poorly correlate with factor XI levels. Spontaneous bleeding is uncommon, whereas delayed po ... Full text Link to item Cite

Spontaneous pregnancy reaches viability after low first trimester serum progesterone: a case report.

Journal Article J Reprod Med · 2012 BACKGROUND: Progesterone is produced by the corpus luteum until completion of the luteal-placental shift at approximately 6-10 weeks following last menstruation. Studies have shown that first trimester progesterone levels are predictive of pregnancy viabil ... Link to item Cite

Novel retrotransposed imprinted locus identified at human 6p25.

Journal Article Nucleic Acids Res · July 2011 Differentially methylated regions (DMRs) are stable epigenetic features within or in proximity to imprinted genes. We used this feature to identify candidate human imprinted loci by quantitative DNA methylation analysis. We discovered a unique DMR at the 5 ... Full text Link to item Cite

Absence of mitochondrial progesterone receptor polymorphisms in women with spontaneous preterm birth.

Journal Article Reprod Sci · October 2010 OBJECTIVE: The truncated mitochondrial progesterone receptor (PR-M) is homologous to nuclear PRs with the exception of an amino terminus hydrophobic membrane localization sequence, which localizes PR-M to mitochondria. Given the matrilineal inheritance of ... Full text Link to item Cite

Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells.

Journal Article Mol Cell Endocrinol · May 5, 2010 Extracellular ATP activates purinergic (P(2)) receptors with an increase in intracellular calcium and phosphorylation of MAPK. In this study we have investigated the effect of progesterone/progestin on ATP-induced calcium mobilization and phosphorylation o ... Full text Link to item Cite

Implanted estrogen pellets associated with hypertriglyceridemia, biliary dyskinesia and focal nodular hyperplasia of the liver: a case report.

Journal Article J Reprod Med · 2010 BACKGROUND: Bioidentical hormones, including implanted estradiol-17beta pellets, have received considerable interest in the lay media. It is thought that parenteral estrogens have fewer gastrointestinal side effects than oral products. CASE: A 46-year-old ... Link to item Cite

Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells.

Journal Article Am J Physiol Endocrinol Metab · November 2009 The effects of progesterone on breast epithelial cells remain poorly defined with observations showing both proliferative and antiproliferative effects. As an example, progesterone levels correlate with increased epithelial cell proliferation, but there is ... Full text Link to item Cite

Early polycystic ovary syndrome as a possible etiology of unexplained premenarcheal ovarian torsion.

Journal Article J Pediatr Adolesc Gynecol · August 2009 STUDY OBJECTIVE: To study evidence of polycystic ovary syndrome (PCOS) in premenarcheal adolescents with unexplained ovarian torsion. DESIGN: Retrospective observational case series. SETTING: Tertiary university clinical center PARTICIPANTS: Six premenarch ... Full text Link to item Cite

A case of female epispadias.

Journal Article Fertil Steril · November 2008 OBJECTIVE: To present a case of unrecognized female epispadias. DESIGN: Case report. SETTING: University-based reproductive endocrinology and fertility clinic. PATIENT(S): A 16-year-old girl with epispadias, history of mild urinary incontinence, auditory n ... Full text Link to item Cite

Effectiveness of assisted reproductive technology (ART).

Journal Article Evid Rep Technol Assess (Full Rep) · May 2008 OBJECTIVES: We reviewed the evidence regarding the outcomes of interventions used in ovulation induction, superovulation, and in vitro fertilization (IVF) for the treatment of infertility. Short-term outcomes included pregnancy, live birth, multiple gestat ... Link to item Cite

Uterine leiomyoma in a 14-year-old girl.

Journal Article Eur J Pediatr Surg · February 2008 Uterine leiomyomas are common benign tumors of the uterus in adult females but are rare in adolescents. This is a review of the literature and a case report of a 14-year-old female who presented with increasing, intermittent back pain and abdominal distent ... Full text Link to item Cite

Aspirin and reproductive outcomes.

Journal Article Obstet Gynecol Surv · January 2008 In the late 1980s and early 1990s, researchers hypothesized that aspirin could be used to prevent or delay the onset of preeclampsia. This hypothesis was tested in numerous trials which showed limited, but positive results. Subsequently, aspirin has been u ... Full text Link to item Cite

Simple vaginal mold for use in the postoperative care of patients with a transverse vaginal septum.

Journal Article Fertil Steril · May 2007 Severe vaginal stenosis is a potentially disabling complication of transverse vaginal septum resection due to the constriction of the resulting circular scar. We describe a vaginal mold that can be easily created by an occupational therapist, and used as a ... Full text Link to item Cite

Actions of steroids in mitochondria.

Journal Article Semin Reprod Med · May 2007 Featured Publication Investigations of indirect and direct actions of steroids on the mitochondria are relatively new areas of research. In this review we provide brief background information regarding mitochondrial structure and function and then focus upon interactions of gl ... Full text Link to item Cite

Non-genomic actions of sex steroids: Preface

Journal Article Seminars in Reproductive Medicine · May 1, 2007 Full text Cite

Non-genomic actions of sex steroids

Journal Article Seminars in Reproductive Medicine · May 1, 2007 Full text Cite

Perspectives: the possible influence of assisted reproductive technologies on transgenerational reproductive effects of environmental endocrine disruptors.

Journal Article Toxicol Sci · April 2007 Demasculinization by environmental endocrine-disrupting chemicals (EDCs) is observed in many animal species but less evident in humans. Rodent studies with gestational exposure to either the fungicide vinclozolin or the insecticide methoxychlor demonstrate ... Full text Link to item Cite

Estrogenic ovulatory dysfunction or functional female hyperandrogenism: an argument to discard the term polycystic ovary syndrome.

Journal Article Fertil Steril · November 2006 Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders seen among reproductive-age women, with a prevalence of 4%-9% depending on the criteria used to define the syndrome. The diagnostic criteria for PCOS have been surprisingly cont ... Full text Link to item Cite

Ectopic pregnancy in a preexisting hydrosalpinx during a spontaneous pregnancy.

Journal Article Fertil Steril · October 2006 OBJECTIVE: To discuss the possible role of abnormal embryo migration as a cause of ectopic pregnancy during IVF with hydrosalpinges. DESIGN: Case report. SETTING: University-based reproductive endocrinology and fertility clinic. PATIENT(S): A patient prese ... Full text Link to item Cite

Binding of progesterone to cell surfaces of human granulosa-lutein cells.

Journal Article J Steroid Biochem Mol Biol · September 2006 Featured Publication Progesterone is produced by granulosa cells under the influence of luteinizing hormone. Nuclear progesterone receptors have been found in rat granulosa cells. Human granulosa-lutein cells rapidly respond to progesterone with an increase in intracellular ca ... Full text Link to item Cite

Discovery of a truncted progesterone receptor (PR-M) in the mitochondria.

Conference JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION · February 1, 2006 Link to item Cite

Identification of a novel truncated progesterone receptor (PR-M) in breast cancers and breast cancer cell lines.

Conference JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION · February 1, 2006 Link to item Cite

Immunofluorescent localization of a novel progesterone receptor(s) in a T47D-Y breast cancer cell line lacking genomic progesterone receptor expression.

Journal Article J Soc Gynecol Investig · December 2005 Featured Publication OBJECTIVE: To identify a novel nongenomic progesterone receptor (PR), PR-M, in T47D-Y breast cancer cells lacking genomic PR expression. METHODS: Immunofluorescent staining of T47D and T47D-Y breast cancer cells with selective anti-PR antibodies and ligand ... Full text Link to item Cite

Relationship between pre-embryo pronuclear morphology (zygote score) and standard day 2 or 3 embryo morphology with regard to assisted reproductive technique outcomes.

Journal Article Fertil Steril · October 2005 OBJECTIVE: To test the hypothesis that pregnancy rates are low if grade Z1 pre-embryos are not available for transfer and to determine if pronuclear morphology is a better predictor of pregnancy than traditional embryo morphology. DESIGN: Prospective clini ... Full text Link to item Cite

Redefining the relationship between sperm deoxyribonucleic acid fragmentation as measured by the sperm chromatin structure assay and outcomes of assisted reproductive techniques.

Journal Article Fertil Steril · August 2005 OBJECTIVE: To test the hypothesis that couples with sperm chromatin structure assay (SCSA) DNA fragmentation index (DFI) values >27% would not achieve pregnancy with assisted reproductive techniques (ART) and to investigate how DFI and high DNA stainabilit ... Full text Link to item Cite

Mullerian agenesis and thrombocytopenia absent radius syndrome: a case report and review of syndromes associated with Mullerian agenesis.

Journal Article Obstet Gynecol Surv · July 2005 UNLABELLED: Mullerian agenesis, commonly referred to as Mayer-Rokitansky-Kuster-Hauser syndrome (MRKHS), is a congenital defect that is most commonly associated with renal and spinal malformations. It is very rare for Mullerian agenesis to be accompanied b ... Full text Link to item Cite

Conclusions about the effects on fertilization of time from aspiration to incubation and blood in the aspirate depend on the use of appropriate statistical techniques.

Journal Article Fertil Steril · June 2004 OBJECTIVE: To examine the effects of exposure to blood and time from aspiration to incubation on oocyte fertilization. DESIGN: Retrospective, cohort study. SETTING: Hospital-based IVF practice. PATIENT(S): Eighty-two women undergoing IVF procedures. INTERV ... Full text Link to item Cite

Membrane-bound progesterone receptor expression in human aortic endothelial cells.

Journal Article J Histochem Cytochem · August 2003 Featured Publication Observational studies demonstrate that estradiol and progesterone affect vasoreactivity. In animal studies, progesterone treatment causes immediate relaxation of precontracted arteries with inhibition of calcium influx in vascular endothelial and smooth mu ... Full text Link to item Cite

Hysteroscopic sterilization using a micro-insert device: results of a multicentre Phase II study.

Journal Article Hum Reprod · June 2003 BACKGROUND: Unlike laparoscopic surgery for interval tubal sterilization, a hysteroscopic approach obviates surgical incision and requires only local anaesthesia or intravenous sedation. The safety, tolerability and efficacy of an hysteroscopically placed ... Full text Link to item Cite

Cloning and expression of a novel, truncated, progesterone receptor.

Journal Article Mol Cell Endocrinol · February 28, 2003 Featured Publication Progesterone acts via two specific receptors to affect gene transcription in target tissues. Progesterone receptor (PR) B contains 933 amino acids while PR A is a truncated version lacking the initial 164 amino acids. We have cloned a novel, truncated PR f ... Full text Link to item Cite

Blood pressure control and hormone replacement therapy in postmenopausal women at risk for coronary heart disease.

Journal Article Am Heart J · April 2002 BACKGROUND: Coronary heart disease (CHD) in women is strongly associated with estrogen deprivation. For example, risk for CHD increases dramatically after menopause. However, the role of hormone replacement therapy (HRT) in CHD prevention currently is unre ... Full text Link to item Cite

Acute ureteral obstruction following transvaginal oocyte retrieval for IVF.

Journal Article Hum Reprod · January 2002 Transvaginal, ultrasound-guided oocyte retrieval has become the gold standard for IVF therapy. Despite a low reported complication rate, here a case is reported of acute ureteral obstruction following seemingly uncomplicated oocyte retrieval. Prompt diagno ... Full text Link to item Cite

Fulminant hepatic failure due to herpes simplex after hysteroscopy.

Journal Article Obstet Gynecol · November 2001 BACKGROUND: Fulminant hepatic failure due to herpes simplex in healthy adults is a rare condition with a high mortality rate. The lack of specific symptoms and the absence of typical herpetic lesions in a majority of cases contribute to delayed diagnosis. ... Full text Link to item Cite

Differential transcriptional activation of peroxisome proliferator-activated receptor gamma by omega-3 and omega-6 fatty acids in MCF-7 cells.

Journal Article Mol Cell Endocrinol · February 25, 2000 While the role of dietary fats in breast cancer remains controversial, the recent cloning of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor, from human breast cancer cells lines provides a potential molecular link. ... Full text Link to item Cite

Finasteride for hirsutism

Journal Article Emergency Medicine · December 1, 1999 There's a new approach to treating hirsutism - but is it any better or even as effective as conventional therapy? An expert assesses the efficacy and risks of finasteride. ... Cite

Finasteride for hirsutism

Journal Article Contemporary Ob-Gyn · December 1, 1999 There's a new approach to treating hirsutism - but is it any better or even as effective as conventional therapy? An expert assesses the efficacy and risks of finasteride. ... Cite

Presence of leptin in breast cell lines and breast tumors.

Journal Article Biochem Biophys Res Commun · June 16, 1999 Leptin is the product of the ob gene, reported to be secreted exclusively from adipocytes and thought to control satiety by providing information to the central nervous system. However, the function of leptin appears to be more complex because multiple stu ... Full text Link to item Cite

Control of air quality in an assisted reproductive technology laboratory.

Journal Article Fertil Steril · January 1999 OBJECTIVE: To investigate the effect of improved air quality on IVF and subsequent embryo development. DESIGN: Retrospective cohort study. SETTING: Hospital-based IVF facility composed of an anteroom, a cleanroom, and an adjacent operating room. PATIENT(S) ... Full text Link to item Cite

Validity and cost-effectiveness of antisperm antibody testing before in vitro fertilization.

Journal Article Fertil Steril · May 1998 OBJECTIVE: To determine the usefulness of and cost-effectiveness of antisperm antibody testing in the prediction of poor fertilization rates in couples undergoing IVF. DESIGN: Retrospective cohort study. SETTING: A hospital-based reproductive endocrinology ... Full text Link to item Cite

Identification of progesterone receptor in human subcutaneous adipose tissue.

Journal Article J Clin Endocrinol Metab · February 1998 Featured Publication Sex steroids are postulated to play a role in adipose tissue regulation and distribution, because the amount and location of adipose tissue changes during puberty and menopause. Because of the nature of adipose tissue, receptors for the female sex steroids ... Full text Link to item Cite

Estrogen regulation of adipose tissue lipoprotein lipase--possible mechanism of body fat distribution.

Journal Article Am J Obstet Gynecol · January 1998 Featured Publication OBJECTIVE: The purpose of this study was to evaluate the regulation of lipoprotein lipase activity, protein mass, and messenger ribonucleic acid by estradiol. STUDY DESIGN: Premenopausal women not taking exogenous sex steroids had transdermal 17 beta-estra ... Full text Link to item Cite

Differences in the estrogen content of breast adipose tissue in women by menopausal status and hormone use.

Journal Article Obstet Gynecol · August 1997 Featured Publication OBJECTIVE: To determine the levels of free estrone (E1) and estradiol (E2) in breast adipocytes of premenopausal women, premenopausal women using oral contraceptives (OCs), postmenopausal women, and postmenopausal women using estrogen replacement therapy ( ... Full text Link to item Cite

MCF-7 and T47D human breast cancer cells contain a functional peroxisomal response.

Journal Article Mol Cell Endocrinol · May 16, 1997 Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that regulate transcription of target genes. Since attempts have been made to correlate the ingestion of high-fat diets, itself a peroxisome proliferator, with the o ... Full text Link to item Cite

Single-dose pharmacokinetics of sublingual versus oral administration of micronized 17 beta-estradiol.

Journal Article Obstet Gynecol · March 1997 Featured Publication OBJECTIVE: To investigate the pharmacokinetic profiles of different doses of micronized 17 beta-estradiol administered by oral or sublingual routes. METHODS: Single doses of micronized 17 beta-estradiol were administered orally (1 mg, 0.5 mg) or sublingual ... Full text Link to item Cite

Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne

Journal Article Bioorganic and Medicinal Chemistry Letters · August 20, 1996 An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed. ... Full text Cite

Relationship between adipose stromal-vascular cells and adipocytes in human adipose tissue.

Journal Article Anal Quant Cytol Histol · April 1996 Featured Publication OBJECTIVE: To determine the relative amounts of RNA and DNA from adipocytes and adipose stromal-vascular cells to better assess differential gene expression for estrogen receptor and cytochrome P450 aromatase in the two cell fractions of adipose tissue. ST ... Link to item Cite

Ablation of luteal phase symptoms of Menière's disease with leuprolide.

Journal Article Arch Otolaryngol Head Neck Surg · February 1994 Symptoms of Menière's disease in women may be exacerbated during the luteal phase of the menstrual cycle. This suggests a role for progesterone production and subsequent fluid redistribution as a predisposing factor for Menière's symptoms. We report the us ... Full text Link to item Cite

A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.

Journal Article J Clin Endocrinol Metab · December 1993 C19 steroids are converted to estrogens in a number of tissues by a specific form of cytochrome P450, namely aromatase cytochrome P450 (P450arom). Adipose tissue is the principal site of estrogen formation in postmenopausal women. Aromatase activity as wel ... Full text Link to item Cite

Determination of estrogen receptor messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification.

Journal Article J Clin Endocrinol Metab · October 1993 Featured Publication Clinical evidence suggests that sex hormones affect adipose tissue metabolism and deposition. To investigate the biosynthesis and possible action of estrogen in adipose tissue, we report the use of competitive, specific polymerase chain reaction amplificat ... Full text Link to item Cite

Single- and multiple-dose pharmacokinetics of a low-dose oral contraceptive in women with chronic renal failure undergoing peritoneal dialysis.

Journal Article Am J Obstet Gynecol · May 1993 Featured Publication OBJECTIVE: Our purpose was to compare the pharmacokinetic parameters of oral administration of a 35 micrograms ethinyl estradiol, 1 mg norethindrone pill in peritoneal dialysis patients and normal women. STUDY DESIGN: A single-dose study was performed with ... Full text Link to item Cite

Determination of aromatase cytochrome P450 messenger ribonucleic acid in human breast tissue by competitive polymerase chain reaction amplification.

Journal Article J Clin Endocrinol Metab · June 1992 Local production of estrogen in breast tissue may influence the growth of breast cancers. Peripheral conversion of C19 steroids to estrogens is catalyzed by the aromatase enzyme complex which is comprised of a specific form of cytochrome P450, aromatase cy ... Full text Link to item Cite

Effect of type 1 transforming growth factor-beta on the level of aromatase cytochrome P-450 in human fetal hepatocytes.

Journal Article J Endocrinol · May 1992 Aromatase cytochrome P-450 (P-450AROM) is the enzyme in the steroidogenic pathway controlling the formation of oestrogens from 19 carbon steroid precursors. Aromatase is present in various tissues of the human fetus. The liver is second only to the placent ... Full text Link to item Cite

Relative expression of aromatase cytochrome P450 in human fetal tissues as determined by competitive polymerase chain reaction amplification.

Journal Article J Clin Endocrinol Metab · April 1992 The aromatase enzyme complex is responsible for the conversion of C19 steroids to estrogens. Aromatase activities ranging from moderate to very low have been measured in human fetal tissues. The inability to demonstrate aromatase cytochrome P450 (P450AROM) ... Full text Link to item Cite

The aromatase enzyme: from cloning to cancer.

Journal Article Princess Takamatsu Symp · 1990 Estrogen production by adipose tissue has been implicated in the etiology of such human cancers as endometrial and breast cancer. Estrogen production by adipose cells is subject to complex multifactorial regulation by a number of growth factors and cytokin ... Link to item Cite

Immunohistochemical localization of prostaglandin endoperoxide synthase in human fetal membranes and decidua.

Journal Article Biol Reprod · October 1989 Prostaglandins play an important role during the maintenance of pregnancy and the initiation of parturition. Prostaglandin endoperoxide synthase activity has been demonstrated in human fetal membranes and decidua. Using immunohistochemical techniques, we i ... Full text Link to item Cite

Obstetrical concerns of epidermolysis bullosa.

Journal Article Obstet Gynecol Surv · August 1988 Epidermolysis bullosa is a group of autosomally inherited diseases involving skin breakdown of varying degrees and severity. Prenatal diagnosis and evaluation of these diseases is reviewed although pregnancy is not generally adversely affected by these dis ... Full text Link to item Cite

Amniotic fluid embolism. Three case reports with a review of the literature.

Journal Article Obstet Gynecol Surv · July 1985 Amniotic fluid embolism is a catastrophic event of the intra- and early postpartum period which may also be seen with cesarean delivery and during abortions. Presenting symptomatology includes respiratory distress with cyanosis, shock, and possibly tonic-c ... Full text Link to item Cite