Journal ArticlePhys Med Biol · May 20, 2021
This paper presents a novel PET geometry for breast cancer imaging. The scanner consists of a 'stadium' (a rectangle with two semi-circles on opposite sides) shaped ring, along with anterior and posterior panels to provide high sensitivity and high spatial ...
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Journal ArticleProceedings of SPIE · May 22, 2020
This paper presents a new high-sensitivity PET geometry for high fidelity MRI-compatible PET breast imaging which can scan both breasts simultaneously and have: high sensitivity and resolution; compatibility with MR-breast imaged volume; complete visualiza ...
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Journal ArticleRadiology · March 2020
The Quantitative Imaging Biomarkers Alliance (QIBA) Profile for fluorodeoxyglucose (FDG) PET/CT imaging was created by QIBA to both characterize and reduce the variability of standardized uptake values (SUVs). The Profile provides two complementary claims ...
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ConferenceProceedings of SPIE - The International Society for Optical Engineering · January 1, 2020
This paper presents a new high-sensitivity PET geometry for high fidelity MRI-compatible PET breast imaging which can scan both breasts simultaneously and have: high sensitivity and resolution; compatibility with MR-breast imaged volume; complete visualiza ...
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Journal ArticleAnn Nucl Med · October 2017
OBJECTIVE: To determine whether the recently introduced Bayesian penalized likelihood PET reconstruction (Q.Clear) increases the visual conspicuity and SUVmax of small pulmonary nodules near the PET resolution limit, relative to ordered subset expectation ...
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Journal ArticleJ Nucl Med · January 2017
UNLABELLED: Three-dimensional (3D) mode imaging is the current standard for PET/CT systems. Dynamic imaging for quantification of myocardial blood flow with short-lived tracers, such as 82Rb-chloride, requires accuracy to be maintained over a wide range of ...
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Journal ArticleAm J Nucl Med Mol Imaging · 2015
[(18)F] sodium fluoride (NaF) PET/CT is a current, clinically relevant method to assess bone metastases. Time-of-flight (TOF) PET provides better statistical data quality, which can improve either lower image noise or improve resolution, or both, depending ...
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Journal ArticleCancer Prev Res (Phila) · September 2013
Aerobic exercise training (AET) is an effective adjunct therapy to attenuate the adverse side-effects of adjuvant chemotherapy in women with early breast cancer. Whether AET interacts with the antitumor efficacy of chemotherapy has received scant attention ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2012
Normalization in Positron Emission Tomography (PET) is essential to correct for sensitivity variation across detector elements and produce uniform images. Currently, the standard normalization protocol for General Electric (GE) systems requires a 20 minute ...
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Journal ArticleJ Appl Clin Med Phys · May 10, 2012
Target localization using single photon emission computed tomography (SPECT) and planar imaging is being investigated for guiding radiation therapy delivery. Previous studies on SPECT-based localization have used computer-simulated or hybrid images with si ...
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Journal ArticleInt J Radiat Oncol Biol Phys · February 1, 2012
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PURPOSE: To evaluate the prognostic significance of different descriptive parameters in head-and-neck cancer patients undergoing pretreatment [F-18] fluoro-D-glucose-positron emission tomography (FDG-PET) imaging. PATIENTS AND METHODS: Head-and-neck cancer ...
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Journal ArticleInt J Radiat Oncol Biol Phys · January 1, 2012
PURPOSE: Functional imaging with [F-18]-fluorodeoxyglucose positron emission tomography (FDG-PET) provides the opportunity to define the physiology of the major salivary glands before and after radiation therapy. The goal of this retrospective study was to ...
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Journal ArticleJournal of Applied Clinical Medical Physics · January 1, 2012
Target localization using single photon emission computed tomography (SPECT) and planar imaging is being investigated for guiding radiation therapy delivery. Previous studies on SPECT-based localization have used computer-simulated or hybrid images with si ...
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Journal Article · December 1, 2011
The basics of positron emission tomography imaging are discussed. Positron emission tomography (PET) is the injection (or inhalation) of a substance containing a positron emitter, the subsequent detection of the emitted radiation by a scanner, and the comp ...
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Journal ArticleNucl Med Commun · September 2011
OBJECTIVES: Positron emission tomography protocols conventionally use a constant scan time per bed position (BP). It may be optimal to spend more time scanning some body sections, particularly the more attenuating sections. The relatively consistent taperi ...
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Journal ArticleAJR Am J Roentgenol · August 2010
OBJECTIVE: There is growing interest in using PET/CT for evaluating early response to therapy in cancer treatment. Although widely available and convenient to use, standardized uptake value (SUV) measurements can be influenced by a variety of biologic and ...
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Journal ArticleProc Natl Acad Sci U S A · March 16, 2010
Tobacco smoking is a chronic, relapsing disorder that constitutes one of the primary preventable causes of death in developed countries. Two of the popular hypotheses to explain the development and maintenance of strong nicotine dependence in cigarette smo ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2009
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Attenuation artifacts in PET are seen when attenuation correction (AC) is not performed and when AC is performed but is based on an incorrect attenuation map. PET attenuation artifacts are generally more profound than the straightforward differences in pho ...
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Journal ArticleInt J Radiat Oncol Biol Phys · March 15, 2009
PURPOSE: A prospective study was performed to formally relate dose-dependent radiologically defined changes in normal brain induced by radiotherapy (RT) to neurocognitive dysfunction in subjects with primary brain tumors. METHODS AND MATERIALS: Adult patie ...
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Journal ArticleMol Imaging Biol · 2009
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OBJECTIVE: Positron emission tomography (PET) imaging at more than 1 h after 2-deoxy-2-[(18)F]fluoro-D: -glucose (FDG) administration may result in less blood pool activity and possibly decreased normal FDG uptake in tissues such as liver. Lower normal bac ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2008
PET system performance and image quality are degraded as body size increases; as size increases so do scatter fractions, random fractions, and attenuation. Based on simulated and acquired data, a fillable, tapering phantom is being developed to measure PET ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2008
In this paper, we present an ultra low-dose CT acquisition and reconstruction technique that provides sufficient image quality for PET attenuation correction while keeping the CT dose to a minimum. With PET/CT, CT is used instead of radioactive transmissio ...
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Journal ArticleNucl Instrum Methods Phys Res B · November 2008
Certain trace elements are vital to the body and elemental imbalances can be indicators of certain diseases including cancer and liver diseases. Neutron Stimulated Emission Computed Tomography (NSECT) is being developed as spectroscopic imaging technique t ...
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Journal ArticleNucl Med Commun · July 2008
BACKGROUND: Coronary artery disease is a leading cause of morbidity and mortality. Multiple imaging modalities are used to screen for significant coronary artery disease. We report the concordance between coronary computed tomography angiography (CTA) and ...
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Journal ArticlePhys Med Biol · June 21, 2008
PET image quality measurements of lesion detectability frequently use a small, radioactive sphere in a larger phantom. The typical analysis of a small single sphere in background has several shortcomings as a measure for detectability and quantitation: the ...
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Journal ArticleJ Nucl Med Technol · March 2008
Using nuclear medicine techniques, physiologic activity and processes can be identified in a way that is unique from other modalities. Oftentimes it is helpful to know the exact location of the physiologic uptake that is visualized on a scan. Knowing the e ...
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ConferenceMedical Physics · January 1, 2008
Purpose: To investigate masking portions of projection data to decrease motion‐related artifacts using iterative image reconstruction techniques. Method and Materials: A phantom was constructed from a water‐filled plastic canister with two air‐filled spher ...
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ConferenceMedical Physics · January 1, 2008
Nuclear Medicine instrumentation continues to progress, both hardware and software. Advances in PET/CT include increased PET sensitivity, respiratory gating, time of flight measurement, and improved image reconstruction algorithms that encorporate more phy ...
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Journal ArticleMol Imaging Biol · 2008
PURPOSE: The presence of contrast materials on computed tomography (CT) images can cause problems in the attenuation correction of positron emission tomography (PET) images. These are because of errors converting the CT attenuation of contrast to 511-keV a ...
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Journal ArticleNeuropsychopharmacology · December 2007
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Fifteen smokers participated in a study investigating brain correlates of nicotine dependence. Dependence was reduced by having subjects switch to denicotinized cigarettes for 2 weeks while wearing nicotine skin patches. Positron emission tomography (PET) ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2007
We have performed physical phantom and simulation study with PET to compare the effects of limiting iterations and post-smoothing. The phantom was designed to mimic small hot lesions typical in FDG PET. The phantom was a body-sized 25 L phantom. Eight 1 cm ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2007
X-ray image quality is highly dependent on object size. Diagnostic image quality can be maintained while controlling dose to a patient with tube current modulation schemes. For PET attenuation correction, much lower requirements are placed on CT image qual ...
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Journal ArticleRadiology · November 2007
PURPOSE: To prospectively determine feasibility of evaluating murine left ventricular (LV) function with electrocardiographically (ECG)-gated blood pool single photon emission computed tomography (SPECT). MATERIALS AND METHODS: All animal studies had insti ...
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Journal ArticleRadiology · July 2007
PURPOSE: To retrospectively compare the sensitivity of a dedicated fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) protocol versus a standard whole-body PET/CT protocol for detection of head and neck cancer, ...
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Journal ArticleNucl Med Commun · November 2006
BACKGROUND: Single photon emission computed tomography (SPECT) with 511 keV photons is a challenging modality and collimators for this purpose require trade-offs among resolution, sensitivity and septal penetration. While PET is the modality of choice for ...
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Journal ArticleProgress in Biomedical Optics and Imaging - Proceedings of SPIE · June 22, 2006
A hybrid, dual modality single photon emission computed tomography (SPECT) and x-ray computed mammotomography (CmT) scanner for dedicated breast and axillary imaging is under development. CmT imaging provides high resolution anatomical images, whereas SPEC ...
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Journal ArticleIEEE Transactions on Nuclear Science · June 1, 2006
An important approach to reconstructing PET and SPECT (PET/SPECT) radiotracer images is to utilize high-resolution information from registered MRI or CT (MRI/CT) images. These methods depend on accurate registration of PET/SPECT and MRI/CT images. Herein, ...
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Journal ArticleMol Imaging Biol · 2006
INTRODUCTION: The accumulation of 3'-deoxy-3'-[F-18]fluorothymidine (FLT) on positron emission tomography (PET) images in patients with glioblastoma multiforme was evaluated and correlated with gadopentetate dimeglumine (Gd-DTPA) enhancement in magnetic re ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2005
It is widely believed that the addictive effects of cigarette smoking derive largely from the rapid absorption of nicotine from the pulmonary system. The immediate effects of an inhaled bolus of nicotine on brain function are thought to provide potent rein ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2005
An investigation of the optimum 3D Lower Energy threshold (LET) setting of the Discovery-RX, a new LYSO based GE research PET/CT scanner is conducted. Methods: Sensitivity and noise equivalent count rate (NECR) performance of the scanner in 3D mode were ev ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2005
To investigate the relationship between NEC and image quality in 2D and 3D PET, while simultaneously optimizing 3D low energy threshold (LET), we have performed a series of phantom measurements. The phantom consisted of 46 1 cm fillable hollow spheres on a ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2005
A new PET detector block has been designed to replace the standard detector of the Discovery ST PET/CT system. The new detector block Is the same size as the original, but consists of an 8×6 (tangential x axial) matrix of crystals rather than the original ...
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Journal ArticleRadiology · February 2005
PURPOSE: To prospectively assess a dedicated, large field of view positron emission tomography (PET) mammographic device for imaging primary breast carcinoma. MATERIALS AND METHODS: Institutional review board approval was obtained for this study, and all p ...
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ConferenceMedical Physics · January 1, 2005
Purpose: To study radiotherapy (RT)‐induced dose‐dependent functional changes in the human cerebral cortex region using serial [formula omitted] and [formula omitted] PET imaging before and after RT. Method and Materials: Eleven human subjects were enrolle ...
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ConferenceIEEE Nuclear Science Symposium Conference Record · December 1, 2004
This paper investigates the potential of magnetic resonance imaging (MRI) to improve the estimation of within-tumor variations in F18-FDG concentration. An image model is described for incorporating MRI images into positron emission tomography (PET) and si ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2004
We have investigated a combined 2D/3D protocol for minimizing contamination in dual tracer P.E.T. studies in which the tracers are administered on a timescale that is short compared to the half-lives. We have performed a series of phantom studies on an Adv ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2004
This paper presents the results of a simulation study on the imaging performance of a bedside cardiac PET system. The proposed system consists of two compact gamma cameras mounted on a mobile gantry. Key challenges presented by this imaging context include ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2004
PET imaging in the pelvis with dual planar detectors has been investigated. The scanner consisted of two 20 cm (transaxial) × 15 cm (axial) planar detectors with 3×3×10 mm 3 LGSO elements mounted on a rotating gantry with adjustable detector radii. A 36 cm ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2004
The performance of a PET scanner on three different phantom sizes was studied as a function of low energy threshold (LET). Phantom cross sections ranged from 20 cm diameter circular to 28 cm × 43 cm oval and LET's ranged from 350 keV to 475 keV, in 25 keV ...
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Journal ArticleRadiology · May 2004
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Positron emission tomography (PET) provides metabolic information that has been documented to be useful in patient care. The properties of positron decay permit accurate imaging of the distribution of positron-emitting radiopharmaceuticals. The wide array ...
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Journal ArticleCancer J · 2004
PET imaging with (18)F-2-deoxy-2-fluoro-D-glucose (FDG-PET) is useful both for the initial evaluation of brain tumors and for follow up after therapy. Over 400 FDG-PET studies are performed at Duke University Medical Center annually for brain tumors. Image ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · December 1, 2003
An important approach to reconstruction of PET and SPECT images is to utilize high-resolution information from registered MRI or CT images. Herein, a PET/SPECT image-reconstruction objective function is presented which includes parameters for the alignment ...
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Journal ArticleDig Dis Sci · September 2003
Previous studies have demonstrated alterations in brain response to rectal distension in patients with irritable bowel syndrome (IBS) compared to controls. Our aim was to compare regional brain activity in response to rectal balloon distension in patients ...
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Journal ArticleJ Cogn Neurosci · April 1, 2003
Positron emission tomography data (Madden, Langley, et al., 2002) were analyzed to investigate adult age differences in the relation between neural activation and the lexical (word frequency) and sublexical (word length) components of visual word identific ...
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Journal ArticleAm J Psychiatry · February 2003
OBJECTIVE: The effects of acute nicotine administration and smoking on brain function were investigated in two studies, with the primary goal of identifying neural systems that mediate these effects. METHOD: In study 1, 18 healthy volunteer cigarette smoke ...
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Journal ArticleIEEE Trans. Nucl. Sci. (USA) · 2003
Image reconstruction for positron emission mammography (PEM) with two parallel, planar detectors is usually performed by backprojection to image planes. Three major factors affecting backprojection image reconstruction are investigated: 1) image uniformity ...
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Journal ArticleIEEE Nuclear Science Symposium Conference Record · January 1, 2003
CT data from PET/CT can be used to produce a 511-keV attenuation map of high statistical quality for PET attenuation correction. However, CT contrast agents can result in regions of overestimated 511 keV attenuation-coefficient values. Resulting attenuatio ...
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Journal ArticlePsychiatry Res · December 30, 2002
While several studies are available on the immediate effects of marijuana and its active ingredient tetrahydrocannabinol (THC) on regional cerebral blood flow (rCBF), we examined the effects of intravenous infusion of THC on rCBF and behavior over a 120-mi ...
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Journal ArticleJ Nucl Med Technol · December 2002
UNLABELLED: 18F-FDG is a well-established tracer for evaluating myocardial viability, as is (99m)Tc-tetrofosmin (TET) for evaluating myocardial perfusion. Dual-isotope single-acquisition (DISA) studies using a (99m)Tc perfusion agent and (18)F-FDG have bee ...
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Journal ArticleIEEE Nuclear Science Symposium and Medical Imaging Conference · December 1, 2002
Dedicated positron emission mammography (PEM) systems provide a potentially high sensitivity, high-resolution, low attenuation and lower cost alternative to whole body PET. We have designed, built, and performed initial evaluation of a large field-of-view ...
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Journal ArticleIEEE Nuclear Science Symposium and Medical Imaging Conference · August 31, 2002
Small spheres are frequently used in radioactive phantoms to investigate lesion detectability and quantitation accuracy. The surrounding walls of fillable spheres displace background solution, and therefore reduce the apparent radioactivity concentration i ...
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Journal ArticleBrain Cogn · August 2002
Adult age differences in the neural systems mediating semantic (context-independent) memory were investigated using positron emission tomography (PET). Younger (20-29 years) and older (62-70 years) participants performed lexical decision (word/nonword disc ...
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Journal ArticleSemin Roentgenol · April 2002
PET imaging is a molecular imaging technology that is diffusing into imaging departments quite rapidly. The unique characteristics of positron emitting radionuclides such as fluorine-18 provide high-quality images with reasonable acquisition times. The ima ...
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Journal ArticlePsychol Aging · March 2002
Positron emission tomography (PET) was used to examine adult age differences in neural activation during visual search. Target detection was less accurate for older adults than for younger adults, but both age groups were successful in using color to guide ...
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Journal ArticleIEEE Nuclear Science Symposium and Medical Imaging Conference · January 1, 2002
Image reconstruction for positron emission mammography (PEM) with the breast positioned between two parallel, planar detectors is usually performed by backprojection to image planes. Three important factors affecting PEM image reconstruction by backproject ...
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Journal ArticleJ Nucl Med Technol · March 2001
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The purpose of this paper is to introduce technologists to the basic principles of PET imaging and to the instrumentation used to acquire PET data. PET imaging is currently being done on a variety of imaging system types, and the technologist will be intro ...
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Journal ArticleIEEE Trans. Nucl. Sci. (USA) · 2001
Depleted uranium (DU) pinhole collimators are evaluated for small-volume SPECT imaging of 511-keV gammas, with a view toward small-animal imaging. Tungsten (W) pinholes are examined for comparison. Line source measurements show planar full-width at half-ma ...
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Journal ArticleIEEE Transactions on Nuclear Science · January 1, 2001
The effect of the axial resolution of transmission data for use in positron emission tomography (PET) attenuation correction is an important consideration for the design of transmission scanning systems. PET transmission data from five patient scans were u ...
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Journal ArticleIEEE Nuclear Science Symposium and Medical Imaging Conference · December 1, 2000
Three-dimensional PET imaging geometries, both on dedicated and hybrid PET systems, are sensitive to radioactivity outside the field of view. To evaluate, compare, and optimized PET systems, then, a phantom with large axial extent is required. Based on rad ...
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Journal ArticleIEEE Nuclear Science Symposium and Medical Imaging Conference · December 1, 2000
PET imaging on hybrid gamma cameras can benefit from the use of some septa, which restrict detection of radiation from outside the field of view, limit scatter, and keep the data more 2D for simplicity of reconstruction. We have built a system with variabl ...
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Journal ArticleSemin Nucl Med · October 2000
Attenuation effects are more severe for coincidence imaging than for single-photon imaging. The capability to measure and correct attenuation now exists with dedicated positron emission tomography (PET) scanners. Attenuation correction may or may not impro ...
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Journal ArticleJ Nucl Med · April 2000
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UNLABELLED: The goal of this research was to develop and evaluate a practical transmission scanning system for attenuation correction on a 2-head gamma camera coincidence scanner. METHODS: The transmission system operates in singles mode and uses point sou ...
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Journal ArticleJ Addict Dis · 2000
BACKGROUND: The focus of this report is on the possible role that the age of first use of marijuana may play on brain morphology and function. METHODS: Magnetic resonance imaging (MRI) and positron emission tomography (PET) were utilized to study 57 subjec ...
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Journal ArticleIEEE Transactions on Nuclear Science · January 1, 2000
Several acquisition geometries were investigated to optimize coincidence count rates and coincidence/singles rate ratios for brain imaging on a rotating gamma camera PET system. Detection efficiency and singles count rate limits on these systems dictate th ...
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Journal ArticleIEEE Trans Med Imaging · December 1999
We have developed a simple method for determining coincidence attenuation-correction factors C (the inverse of the total attenuation factors) from collimated singles (SPECT) and coincidence [positron emission tomography (PET)] projections without transmiss ...
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Journal ArticleJ Cogn Neurosci · September 1999
We used H(2)15O positron emission tomography (PET) to measure age-related changes in regional cerebral blood flow (rCBF) during a verbal recognition memory task. Twelve young adults (20 to 29 years) and 12 older adults (62 to 79 years) participated. Separa ...
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Journal ArticleActa Psychiatr Scand · July 1999
OBJECTIVE: The aim of this study was to examine the relationship between depersonalization induced by tetrahydrocannabinol (THC), and regional brain activation. METHOD: Cerebral blood flow (CBF) was measured by means of positron emission tomography (PET) i ...
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Journal ArticleAJR Am J Roentgenol · April 1999
OBJECTIVE: The purpose of this study was to correlate 18F-fluorodeoxyglucose positron emission tomography (PET) and MR imaging features of cerebral gangliogliomas before and after PET-MR image registration. CONCLUSION: After registration of PET and MR imag ...
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Journal ArticleRadiology · March 1999
PURPOSE: To evaluate 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) imaging of simulated lung nodules in a realistic chest phantom by using attenuation-corrected and non-attenuation-corrected 511-keV single photon emission computed tomography (SPECT), camer ...
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Journal ArticleLung Cancer · February 1999
The purpose of this study was to determine the utility of quantitative single photon emission computed tomography (SPECT) lung perfusion scans and F-18 fluorodeoxyglucose positron emission computed tomography (PET) during X-ray computed tomography (CT)-bas ...
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Journal ArticleHum Brain Mapp · 1999
Adult age differences are frequently observed in the performance of memory tasks, but the changes in neural function mediating these differences are largely unknown. We used (H2)15O positron emission tomography (PET) to measure changes in regional cerebral ...
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Journal ArticleClin Positron Imaging · January 1999
The purpose of this study is to compare the quality of images and the results of camera-based and dedicated position emission tomography (PET) in the same patients with suspected recurrent or persistent brain tumor after therapy. Both PET studies were inte ...
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Journal ArticleIEEE Transactions on Nuclear Science · January 1, 1999
The axial imaging properties of the transmission scanning system for attenuation correction of gamma camera coincidence imaging are evaluated. This system uses multiple Cs-137 point sources collimated by transaxial septa already in place for emission imagi ...
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Journal ArticleIEEE Nuclear Science Symposium and Medical Imaging Conference · January 1, 1999
We have developed a simple method for determining attenuation-correction factors C (the inverse of the total attenuation factors) from collimated singles (SPECT) and coincidence (PET) projections without the need for transmission data. Attenuation-correcti ...
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Journal ArticleIEEE Transactions on Nuclear Science · December 1, 1998
Images produced by gamma camera coincidence (GCC) techniques have a much lower count-density than those produced by dedicated PET scanners. We examine the effects of attenuation and attenuation correction on GCC images using gamma-camera emission data and ...
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Journal ArticleMagn Reson Med · August 1998
The objectives of this study were to define the relationship between the first order constant of Gd-DTPA transfer (K1) and the myocardial blood flow (MBF) at rest and to compare it with an equivalent relationship obtained for positron emission tomography ( ...
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Journal ArticleBrain Res · June 29, 1998
Because marijuana continues to be the most commonly used illicit drug, its effects on the brain function are of major interest. We utilized positron emission tomography (PET) and magnetic resonance imaging (MRI) to study the effects of delta-9-tetrahydroca ...
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Journal ArticleIEEE Transactions on Nuclear Science · January 1, 1998
The purpose of this work was to evaluate lesion detectability with and without nonuniform attenuation compensation (AC) in myocardial perfusion SPECT imaging in women using an anthropomorphic phantom and receiver operating characteristics (ROC) methodology ...
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Journal ArticleIEEE Transactions on Nuclear Science · December 1, 1997
Because of the interest in low-cost instrumentation for imaging positron emitters and because of the low detection efficiency of conventional 3/8 Nal(Tl) gamma cameras for 511 keV photons, basic imaging characteristics have been evaluated on a SPECT system ...
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Journal ArticleIEEE Transactions on Nuclear Science · December 1, 1997
A technique was developed to align images from dynamic cardiac N-13 ammonia positron emission tomography (PET) scans. Inaccurate alignment of images from these scans stems from breathing, motion of the heart within the thorax, and overall motion of the pat ...
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Journal ArticleIEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1997
Images produced by gamma camera coincidence (GCC) techniques fall into a much lower count-density regime than those produced by PET. We examine the effects of attenuation and attenuation correction on GCC images using gamma-camera emission data and PET emi ...
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Journal ArticleIEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1997
The purpose of this work was to evaluate lesion detectability with and without nonuniform attenuation compensation (AC) in myocardial perfusion SPECT imaging in women using an anthropomorphic phantom and receiver operating characteristics (ROC) methodology ...
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Journal ArticleIEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1997
This study compared two approaches for acquiring transmission computed tomography (TCT) data for SPECT nonuniform attenuation compensation. One approach, which has been implemented in commercial SPECT systems, acquires the TCT and SPECT data simultaneously ...
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Journal ArticleIEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1997
A scheme for correcting scattered events in gamma camera coincidence imaging is presented and evaluated in line source, cold rod, and brain phantom data. The algorithm makes use of the difference in proportion of scattered and unscattered events in two typ ...
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Journal ArticleIEEE Trans Med Imaging · October 1997
In recent years, many investigators have proposed Gibbs prior models to regularize images reconstructed from emission computed tomography data. Unfortunately, hyperparameters used to specify Gibbs priors can greatly influence the degree of regularity impos ...
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Journal ArticleLife Sci · 1997
OBJECTIVE AND METHOD: The acute effects of delta9 tetrahydrocannabinol (THC) on cerebral blood flow (CBF) were studied in human subjects. Regional CBF was measured with 15O-water and Positron Emission Tomography (PET) in 32 volunteers with a history of exp ...
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Journal ArticleHuman brain mapping · January 1997
Regional cerebral blood flow (rCBF) was measured using H2(15)O and positron emission tomography (PET) to test the hypothesis that age-related changes in the pattern of rCBF activation would be greater under divided attention conditions than under selective ...
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Journal ArticleIEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1996
Because of the interest in low-cost instrumentation for imaging positron emitters, and because of the low detection efficiency of conventional 3/8 inches NaI(Tl) gamma cameras for 511 keV photons, basic imaging characteristics have been evaluated on a SPEC ...
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Journal ArticleNeuroimage · April 1996
We used H215O PET to investigate adult age differences in regional cerebral blood flow (rCBF) during the performance of a visual word identification task. The study participants were 20 healthy, right-handed men: 10 young adults between 18 and 27 years of ...
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Journal ArticleIEEE Trans. Nucl. Sci. (USA) · 1996
The performance of a pinhole collimator for I-131 SPECT of the head was evaluated. The evaluation included planar and SPECT spatial resolution, sensitivity in air and in water, septal penetration, reconstructed image quality, and activity quantitation with ...
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Journal ArticleJ Nucl Cardiol · 1996
BACKGROUND: Although several modeling strategies have been developed and validated for quantification of myocardial blood flow (MBF) from 13N-labeled ammonia positron emission tomographic data, a comparison of noise characteristics of the various technique ...
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Journal ArticleIEEE Trans Med Imaging · 1996
A Bayesian method is presented for simultaneously segmenting and reconstructing emission computed tomography (ECT) images and for incorporating high-resolution, anatomical information into those reconstructions. The anatomical information is often availabl ...
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Journal ArticleIEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1995
The performance of a pinhole collimator for I-131 SPECT of the head was evaluated. The evaluation included planar and SPECT spatial resolution, sensitivity in air and in water, reconstructed image quality, and activity quantitation within a simple phantom ...
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Journal ArticleJ Comput Assist Tomogr · 1995
OBJECTIVE: The accuracy of a surface-fitting image registration technique has been investigated for matching [18F]fluorodeoxyglucose (FDG) and [15O]H2O PET brain images with MR images. Use of partial-brain surfaces (a single hemisphere or a limited number ...
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Journal ArticleNucl Med Biol · January 1995
We have evaluated SPECT and two planar imaging methods, geometric mean (GM) and buildup factor (BF), for their potential to quantitate in vivo 211At distributions in rat spinal subarachnoid spaces using phantom studies. The use of medium-energy collimators ...
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Journal ArticleJ Nucl Med · October 1994
UNLABELLED: The goals of this study were to investigate the effect of septal penetration on 123I SPECT activity quantitation using low-energy, high-resolution collimators, and to evaluate a semi-automatic method for measuring volume and activity of 123I di ...
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Journal ArticleJ Nucl Med · August 1994
METHODS: This study characterizes the performance of a newly developed whole-body PET scanner (Advance, General Electric Medical Systems, Milwaukee, WI). The scanner consists of 12,096 bismuth germinate crystals (4.0 mm transaxial by 8.1 mm axial by 30 mm ...
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Journal ArticlePhys Med Biol · March 1994
A 3D physical model for iterative reconstruction in SPECT has been developed and applied to experimental data. The model incorporates non-uniform attenuation using reconstructed transmission CT data and distance-dependent detector response based on respons ...
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Journal ArticleIEEE Transactions on Nuclear Science · January 1, 1994
PET transmission scanning in the presence of emission activity has been investigated on two scanners with orbiting pin transmission sources. One phantom consisting of varying sized spherical inserts in a uniform background and another containing simulated ...
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Journal ArticleJ Nucl Med · January 1994
UNLABELLED: To evaluate lesion detectability for clinical evaluation of cone-beam (CB), fanbeam (FB) and parallel-beam (PB) collimator sensitivity, experimentally acquired phantom data were used to assess the advantage of CB collimation over conventional c ...
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Journal ArticleIEEE Nuclear Science Symposium & Medical Imaging Conference · January 1, 1994
In SPECT and PET imaging, radiopharmaceutical concentration is often strongly correlated with anatomical structure. A Bayesian image reconstruction procedure is presented that uses this a priori knowledge to improve the detection and quantification of an u ...
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Journal ArticleIEEE Nuclear Science Symposium & Medical Imaging Conference · January 1, 1994
PET transmission scanning in the presence of emission activity has been investigated on two scanners with orbiting pin transmission sources. One phantom consisting of varying sized spherical inserts in a uniform background and another containing simulated ...
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Journal ArticleJ Nucl Med · September 1993
Accuracy of a surface-fitting algorithm for three-dimensional image registration of single photon emission computed tomography (SPECT), positron emission tomography (PET), and magnetic resonance (MR) images was tested using a three-dimensional, water-filla ...
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Journal ArticlePhys Med Biol · August 1993
We have investigated standard SPECT techniques (rotating gamma cameras, multi-hole collimators, and filtered backprojection reconstruction) for imaging astatine-211 distributions. Since 211At emits alpha particles, this nuclide has potential for use in rad ...
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Journal ArticleInt J Radiat Oncol Biol Phys · July 15, 1993
PURPOSE: Three-dimensional single photon emission computed tomography lung perfusion scans (SPECT) provide a unique quantitative 3-dimensional map of the distribution of functioning pulmonary vascular/alveolar subunits, information not provided by other im ...
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Journal ArticleClin Nucl Med · July 1993
Image registration techniques will become increasingly important in correlative multimodality imaging. In the case of PET, a structural imaging study can be invaluable in correlating structure metabolism relationships. A registered brain atlas of PET and M ...
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Journal ArticleIEEE Trans. Nucl. Sci. (USA) · 1993
The attenuation of 140-keV photons is measured in three empty skulls by placing a 99mTc line source inside each one and acquiring projection data. These projections are compared to projections of the line source alone in order to determine the transmission ...
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Journal ArticleIEEE Transactions on Nuclear Science · January 1, 1993
We have developed three methods to combine parallel and cone bean (P & CB) SPECT data using modified Maximum Likelihood-Expectation Maximization (ML-EM) algorithms. The first combination method applies both parallel and cone beam data sets to reconstruct a ...
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Journal ArticleIEEE Transactions on Nuclear Science · January 1, 1993
Two physical factors that substantially degrade quantitative accuracy in SPECT imaging of the brain are attenuation and detector response. In addition to the physical factors, random noise in the reconstructed image can greatly affect the quantitative meas ...
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Journal ArticlePhys Med Biol · March 1992
A three-dimensional reconstruction method for simultaneous compensation of attenuation, scatter and distance-dependent detector response for single photon emission computed tomography is described and tested by experimental studies. The method determines t ...
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Journal ArticleIEEE Transactions on Nuclear Science · January 1, 1992
The accuracy of a surface fitting technique was investigated for registration of SPECT brain images. Fiduciary markers were placed on the outside of a three-dimensional brain phantom filled with Tc-99m solution. The phantom and markers were scanned at seve ...
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Journal ArticleIEEE Transactions on Nuclear Science · January 1, 1991
The potential of SPECT to quantify the distribution of indium-111 was investigated in an experimental phantom study. Non-uniform attenuation compensation using acquired transmission data was compared to uniform compensation based on reconstructed quantitat ...
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