Scholars@Duke
Kenneth Heaton Wilson

Kenneth Heaton Wilson

Professor Emeritus of Medicine
Medicine, Infectious Diseases
wilso003@mc.duke.edu
315 Trent Dr Room 154, Box 102359, Durham, NC 27710

Selected Publications

A simple HEPA filtering facepiece.

Journal Article Am J Infect Control · September 2021 Shortages of efficient filtering facepiece respirators leave the public vulnerable to transmission of infectious diseases in small particle aerosols. This study demonstrates that a high-filtration-efficiency facepiece capable of filtering out >95% of 0.05μ ... Full text Link to item Cite

Modified African Ngoma Healing Ceremony for Stress Reduction: A Pilot Study.

Journal Article J Altern Complement Med · October 2017 OBJECTIVE: Indigenous people's ceremonies using rhythm and dance have been used for countless generations throughout the world for healing, conflict resolution, social bonding, and spiritual experience. A previous study reported that a ceremony based on th ... Full text Link to item Cite

Therapeutic Potential of a Drum and Dance Ceremony Based on the African Ngoma Tradition.

Journal Article J Altern Complement Med · August 2015 OBJECTIVE: Ngoma ceremonies are used throughout Central and South Africa to help people address "difficult issues," including medical illness. They are examples of ceremonies that use strong rhythms and dance for this purpose in indigenous cultures through ... Full text Link to item Cite

Whipple disease research accelerates.

Journal Article J Infect Dis · July 1, 2011 Featured Publication Full text Link to item Cite

Medicine's missing dimension.

Journal Article Trans Am Clin Climatol Assoc · 2010 Featured Publication In medicine we tend to restrict practice to using a purely intellectual understanding grounded in science to conceptualize patients and their illnesses. This approach is radically different from the experientially rich healing practices found throughout th ... Link to item Cite

A comparison of the effectiveness of lipid-lowering therapy between HIV- and non-HIV-infected subjects with hyperlipidaemia.

Journal Article Int J STD AIDS · December 2007 This retrospective cohort study conducted at the Durham Veterans Affairs Medical Center evaluated the effectiveness and safety of lipid-lowering therapy (LLT) in a HIV-infected population as compared with a general population with hyperlipidaemia. Fifty-th ... Full text Link to item Cite

Association between pharmacy medication refill-based adherence rates and cd4 count and viral-load responses: A retrospective analysis in treatment-experienced adults with HIV.

Journal Article Clin Ther · April 2007 Featured Publication BACKGROUND: Current guidelines and most contemporary statements in the literature indicate that, like other medical conditions, HIV infection requires exceptionally high adherence to highly active antiretroviral therapy (HAART) for successful treatment. OB ... Full text Link to item Cite

Comparison of fecal biota from specific pathogen free and feral mice.

Journal Article Anaerobe · 2006 Featured Publication Specific pathogen free (SPF) rodents are derived from germfree animals that are colonized with Schaedler's flora, a cocktail of eight bacterial strains isolated from the natural biota of mice. During successive generations SPF animals acquire a complex bio ... Full text Link to item Cite

Ribosomal DNA sequence analysis of mucosa-associated bacteria in Crohn's disease.

Journal Article Inflamm Bowel Dis · November 2004 BACKGROUND: Enteric bacteria are implicated in the pathogenesis of Crohn's disease (CD); however, no specific causative organisms have been identified. AIMS: This study was undertaken to correlate disease activity with changes in intestinal biota in patien ... Full text Link to item Cite

Probiotics and prebiotics

Journal Article ASM NEWS · September 1, 2004 Link to item Cite

Benefits and harms of doxycycline treatment for Gulf War veterans' illnesses: a randomized, double-blind, placebo-controlled trial.

Journal Article Ann Intern Med · July 20, 2004 BACKGROUND: It has been hypothesized that certain Mycoplasma species may cause Gulf War veterans' illnesses (GWVIs), chronic diseases characterized by pain, fatigue, and cognitive symptoms, and that affected patients may benefit from doxycycline treatment. ... Full text Link to item Cite

Endocarditis caused by Staphylococcus aureus with reduced susceptibility to vancomycin.

Journal Article Clin Infect Dis · April 15, 2004 Clinical management of infective endocarditis (IE) is expected to become more difficult with the emergence of Staphylococcus aureus with reduced susceptibility to vancomycin (SARV) in the United States and worldwide. We report the strain characterization a ... Full text Link to item Cite

High-density microarray of small-subunit ribosomal DNA probes.

Journal Article Appl Environ Microbiol · May 2002 Ribosomal DNA sequence analysis, originally conceived as a way to provide a universal phylogeny for life forms, has proven useful in many areas of biological research. Some of the most promising applications of this approach are presently limited by the ra ... Full text Link to item Cite

Differential induction of colitis and gastritis in HLA-B27 transgenic rats selectively colonized with Bacteroides vulgatus or Escherichia coli.

Journal Article Infect Immun · June 1999 Resident bacteria play an important role in initiating and perpetuating gastrointestinal inflammation. We previously demonstrated that six commensal bacteria including Bacteroides vulgatus caused more aggressive colitis and gastritis in HLA-B27 transgenic ... Full text Link to item Cite

Varying cecal bacterial loads influences colitis and gastritis in HLA-B27 transgenic rats.

Journal Article Gastroenterology · February 1999 BACKGROUND & AIMS: Recent data support an important role of resident luminal bacteria in experimental colitis. We determined how altered cecal bacterial loads influence colitis and gastritis. METHODS: A cecal self-filling blind loop (SFBL) was created or t ... Full text Link to item Cite

Alpha1-adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding alpha1-adrenergic receptor subtypes at four distinct levels.

Journal Article Brain Res Mol Brain Res · January 8, 1999 alpha1-Adrenergic receptors (alpha1ARs) are important in lower urinary tract syndromes such as benign prostatic hypertrophy and bladder irritability. Spinal cord alpha1ARs have been postulated to play a role in modulating these diseases, yet alpha1AR subty ... Full text Link to item Cite

Bartonella clarridgeiae, a newly recognized zoonotic pathogen causing inoculation papules, fever, and lymphadenopathy (cat scratch disease).

Journal Article J Clin Microbiol · July 1997 Shortly after adopting a 6-week-old cat, a veterinarian was bitten on the left index finger. Within 3 weeks, he developed headache, fever, and left axillary lymphadenopathy. Initial blood cultures from the cat and veterinarian were sterile. Repeat cultures ... Full text Link to item Cite

Characterization of the variable-number tandem repeats in vrrA from different Bacillus anthracis isolates.

Journal Article Appl Environ Microbiol · April 1997 PCR analysis of 198 Bacillus anthracis isolates revealed a variable region of DNA sequence differing in length among the isolates. Five polymorphisms differed by the presence of two to six copies of the 12-bp tandem repeat 5'-CAATATCAACAA-3'. This variable ... Full text Link to item Cite

Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats.

Journal Article J Clin Invest · August 15, 1996 Genetic and environmental factors are important in the pathogenesis of clinical and experimental chronic intestinal inflammation. We investigated the influence of normal luminal bacteria and several groups of selected bacterial strains on spontaneous gastr ... Full text Link to item Cite

Human colonic biota studied by ribosomal DNA sequence analysis.

Journal Article Appl Environ Microbiol · July 1996 Human colonic biota is a complex microbial ecosystem that serves as a host defense. Unlike most microbial ecosystems, its composition has been studied extensively by relatively efficient culture methods. We have compared an established culture-based method ... Full text Link to item Cite

Bartonella vinsonii subsp. berkhoffii subsp. nov., isolated from dogs; Bartonella vinsonii subsp. vinsonii; and emended description of Bartonella vinsonii.

Journal Article Int J Syst Bacteriol · July 1996 Two bacterial strains, one isolated from the blood of a dog with valvular endocarditis and one isolated from the blood of a healthy dog, were similar to Bartonella species, as determined by a number of phenotypic criteria, including growth characteristics, ... Full text Link to item Cite

Identification of a region of genetic variability among Bacillus anthracis strains and related species.

Journal Article J Bacteriol · January 1996 The identification of a region of sequence variability among individual isolates of Bacillus anthracis as well as the two closely related species, Bacillus cereus and Bacillus mycoides, has made a sequence-based approach for the rapid differentiation among ... Full text Link to item Cite

Sutterella wadsworthensis gen. nov., sp. nov., bile-resistant microaerophilic Campylobacter gracilis-like clinical isolates.

Journal Article Int J Syst Bacteriol · January 1996 Campylobacter gracilis (formerly Bacteroides gracilis) is an asaccharolytic, nitrate-positive, urease-negative organism that requires formate and fumarate or hydrogen as a growth additive and may pit agar media. Clinical isolates that were obtained primari ... Full text Link to item Cite

Prolonged Bartonella bacteremia in cats associated with cat-scratch disease patients.

Journal Article Journal of clinical microbiology · December 1995 Recent evidence supports a causal relationship between Bartonella (Rochalimaea) henselae, cat-scratch disease (CSD), and bacillary angiomatosis. Cats appear to be the primary reservoir. Blood from 19 cats owned by 14 patients diagnosed with CSD was culture ... Full text Cite

alpha 2-Adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding alpha 2-adrenergic receptor subtypes at four distinct levels.

Journal Article Brain Res Mol Brain Res · December 1, 1995 alpha 2-Adrenergic receptor (AR) subtype mRNA (alpha 2a, alpha 2b, alpha 2c) neuronal localization in human spinal cord has not been described. We therefore performed in situ hybridization to identify cell bodies at four levels of human spinal cord (cervic ... Full text Link to item Cite

Whipple's disease

Journal Article Current Opinion in Infectious Diseases · October 20, 1995 Whipple's disease is a multisystem infection caused by a unique, culture-resistant Gram-positive bacterium. Mechanisms of pathogenesis and the interplay of the pathogen with the immune system are poorly understood. It has recently been shown to infect red ... Full text Cite

Genetic variability of Bacillus anthracis and related species.

Journal Article J Clin Microbiol · July 1995 We evaluated the abilities of pulsed-field gel electrophoresis (PFGE) and sequences of intergenic spacer regions (ISRs) between two highly conserved genes, 16S-23S rDNA and gyrB-gyrA ISRs, to detect variation in strains of Bacillus anthracis as well as two ... Full text Link to item Cite

Bartonella henselae: etiology of pulmonary nodules in a patient with depressed cell-mediated immunity.

Journal Article Clin Infect Dis · June 1995 We describe an immunocompromised renal transplantation patient with opportunistic lung infection due to Bartonella henselae (formerly Rochalimaea henselae) and provide evidence suggesting transmission from a pet cat. Computed tomographic scans of the chest ... Full text Link to item Cite

Molecular biology as a tool for taxonomy.

Journal Article Clin Infect Dis · June 1995 Bacterial taxonomy based on phenotypic properties has encountered several problems: many organisms grow to poorly under laboratory conditions to be studied; the same phenotypic property often arises independently in more than one branch of a phylogenetic t ... Full text Link to item Cite

Adenomas induced by polycyclic aromatic hydrocarbons in strain A/J mouse lung correlate with time-integrated DNA adduct levels.

Journal Article Cancer Res · March 1, 1995 The induction of DNA adducts and adenomas in the lungs of strain A/J mice has been investigated following the single i.p. administration of each of the following polycyclic aromatic hydrocarbons (PAH): pyrene, dibenz[a,h]anthracene, benzo[a]pyrene, benzo[b ... Link to item Cite

Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.

Journal Article J Pharmacol Exp Ther · January 1995 We have cloned cDNAs encoding three human alpha-1 adrenergic receptor (AR) subtypes and characterized pharmacological properties of the expressed receptor protein. A number of significant sequence corrections have been identified and compared with previous ... Link to item Cite

Endocarditis in a dog due to infection with a novel Bartonella subspecies.

Journal Article J Clin Microbiol · January 1995 Vegetative valvular endocarditis involving the aortic and, to a lesser extent, mitral valves was diagnosed echocardiographically in a 3-year-old spayed female Labrador retriever. Historically, the dog had been treated with tetracycline hydrochloride and pr ... Full text Link to item Cite

Tumor multiplicity, DNA adducts and K-ras mutation pattern of 5-methylchrysene in strain A/J mouse lung.

Journal Article Carcinogenesis · November 1994 This study was undertaken to evaluate the carcinogenic potential of 5-methylchrysene (5-MeC) in strain A/J mouse lung and to correlate the 5-MeC-DNA adduct profile in lung tissue with the mutation spectrum in the K-ras gene of lung tumors. Strain A/J mice ... Full text Link to item Cite

Preliminary study using species-specific oligonucleotide probe for rRNA of Bilophila wadsworthia.

Journal Article J Clin Microbiol · October 1994 Portions of the 16S RNA from a urease-positive Bilophila wadsworthia strain were sequenced, and a probe was constructed. The probe was end labeled with [32P]ATP and polynucleotide kinase and hybridized on a nylon filter (by dot blot hybridization) to the i ... Full text Link to item Cite

Extensive DNA sequence conservation throughout the Mycobacterium tuberculosis complex.

Journal Article J Clin Microbiol · July 1994 The Mycobacterium tuberculosis complex includes the four species M. tuberculosis, M. bovis, M. africanum, and M. microti. We sequenced 13 M. tuberculosis complex strains in the 16S-to-23S rDNA internal transcribed spacer (ITS). The ITS has a high rate of n ... Full text Link to item Cite

Detection of culture-resistant bacterial pathogens by amplification and sequencing of ribosomal DNA.

Journal Article Clin Infect Dis · June 1994 Molecular phylogeny is profoundly influencing the field of bacterial evolution. New knowledge in this area has led to an exciting ability to detect and classify bacteria without culturing them. The process involved consists of either amplification or cloni ... Full text Link to item Cite

Molecular phylogeny of the Mycobacterium avium complex demonstrates clinically meaningful divisions.

Journal Article J Infect Dis · February 1994 Phylogenetic analysis of nucleotide sequence data is widely used for viral epidemiology. To explore its use in bacterial strain differentiation, the variable 16S-23S rDNA internal transcribed spacer (ITS) in 24 clinical isolates originally identified as My ... Full text Link to item Cite

The use of a polymerase chain reaction as a diagnostic test for Rocky Mountain spotted fever.

Journal Article Am J Trop Med Hyg · January 1994 A polymerase chain reaction (PCR) for amplifying ribosomal DNA of Rickettsia rickettsii was performed on blood clots and urine samples from 10 patients with suspected Rocky Mountain spotted fever (RMSF) and five controls with nonrickettsial diseases. The r ... Link to item Cite

The microecology of Clostridium difficile.

Journal Article Clin Infect Dis · June 1993 An understanding of the microecology of Clostridium difficile provides for a better understanding of the disease that this organism causes. C. difficile is not a significant component of the microflora in the colon of healthy adult humans or animals; howev ... Full text Link to item Cite

Sequence-based differentiation of strains in the Mycobacterium avium complex.

Journal Article J Bacteriol · May 1993 The complete 16S-23S rDNA internal transcribed spacer (ITS) was sequenced in 35 reference strains of the Mycobacterium avium complex. Twelve distinct ITS sequences were obtained, each of which defined a "sequevar"; a sequevar consists of the strain or stra ... Full text Link to item Cite

Assignment of the agent of Tyzzer's disease to Clostridium piliforme comb. nov. on the basis of 16S rRNA sequence analysis.

Journal Article Int J Syst Bacteriol · April 1993 The small-subunit rRNA (16S rRNA) sequence of Tyzzer's bacillus (also known as "Bacillus piliformis") was elucidated by using the polymerase chain reaction followed by reverse transcriptase sequencing. By using maximum-likelihood analysis, a phylogenetic t ... Full text Link to item Cite

Identification of the Whipple's disease bacillus.

Journal Article N Engl J Med · January 7, 1993 Full text Link to item Cite

Ribosomal DNA sequences of bifidobacteria: Implications for sequence-based identification of the human colonic flora

Journal Article Microbial Ecology in Health and Disease · January 1, 1993 We sequenced 16S ribosomal DNA from eight Bifidobacterium strains to explore the feasibility of using ribosomal RNA sequence to characterise the human colonic flora. The genus was well defined by this method. Closely related species could be readily distin ... Full text Cite

Bacillary angiomatosis in a child undergoing chemotherapy.

Journal Article J Pediatr · October 1992 Bacillary angiomatosis is an infectious disease of the skin and viscera characterized by vascular lesions, originally described in patients with human immunodeficiency virus infection. There are also case reports of bacillary angiomatosis occurring in immu ... Full text Link to item Cite

UV absorption complicates PCR decontamination.

Journal Article Biotechniques · August 1992 UV irradiation is widely used to inactivate contaminating DNA in PCR. Highly UV-absorbent deoxyribonucleoside triphosphates in PCR mixtures reduce the efficiency of UV decontamination. Optimal decontamination may be achieved by irradiating the PCR mixture ... Link to item Cite

Ehrlichia chaffeensis, a new species associated with human ehrlichiosis.

Journal Article J Clin Microbiol · December 1991 The bacterial 16S rRNA genes from blood samples of two patients with human ehrlichiosis and from an isolate recovered from one of the patients were amplified by using the polymerase chain reaction. The amplimers were then cloned and sequenced. The 16S rRNA ... Full text Link to item Cite

Isolation and characterization of an Ehrlichia sp. from a patient diagnosed with human ehrlichiosis.

Journal Article J Clin Microbiol · December 1991 A new disease was recognized in the United States in 1986. The etiologic agent, although not previously isolated from a human, appeared to be serologically related to Ehrlichia canis, a canine leukotropic rickettsia. We obtained blood specimens from 27 feb ... Full text Link to item Cite

Phylogeny of the Whipple's-disease-associated bacterium.

Journal Article Lancet · August 24, 1991 Efforts to culture and identify the intracellular bacteria associated with Whipple's disease have been unsuccessful. Nucleotide sequencing and amplification by the polymerase chain reaction was done on the bacterial 16 S ribosomal DNA present in a small-bo ... Full text Link to item Cite

Rapid 16S ribosomal DNA sequencing from a single colony without DNA extraction or purification.

Journal Article Biotechniques · July 1991 Ribosomal RNA sequences are useful for establishing phylogenetic relationships, for oligonucleotide probes and for characterization of uncultured organisms. We describe rapid ribosomal DNA sequencing using PCR with transcript sequencing. Nucleic acid speci ... Link to item Cite

The agent of bacillary angiomatosis.

Journal Article N Engl J Med · May 23, 1991 Full text Link to item Cite

THE AGENT OF BACILLARY ANGIOMATOSIS

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · May 23, 1991 Link to item Cite

Amplification of bacterial 16S ribosomal DNA with polymerase chain reaction.

Journal Article J Clin Microbiol · September 1990 The sequence of small-subunit rRNA varies in an orderly manner across phylogenetic lines and contains segments that are conserved at the species, genus, or kingdom level. By directing oligonucleotide primers at sequences conserved throughout the eubacteria ... Full text Link to item Cite

Impact of encephalopathy on mortality in the sepsis syndrome. The Veterans Administration Systemic Sepsis Cooperative Study Group.

Journal Article Crit Care Med · August 1990 Sepsis, an important cause of hospital mortality, continues to be a diagnostic and therapeutic challenge. To define more clearly the impact of encephalopathy on the course of sepsis, the various clinical signs of sepsis, blood culture results, and mortalit ... Full text Link to item Cite

Probe directed at a segment of Rickettsia rickettsii rRNA amplified with polymerase chain reaction.

Journal Article J Clin Microbiol · December 1989 In an effort to explore a sensitive taxon-specific detection system for bacteria, we sequenced the 16S rRNA from two strains of Rickettsia rickettsii, five other rickettsiae, and Coxiella burnetti to find a probe site unique to R. rickettsii. We then synth ... Full text Link to item Cite

Bacterial colonization of intravenous catheter materials in vitro and in vivo.

Journal Article Surgery · July 1989 Four different intravenous catheter materials, brands Teflon, Silastic, Vialon, and Tecoflex, were evaluated in vitro for bacterial adherence after 2 and 24 hours' incubation in trypticase soy broth and after 2 hours' incubation in nutrient-free phosphate ... Link to item Cite

Species-specific oligonucleotide probes for rRNA of Clostridium difficile and related species.

Journal Article J Clin Microbiol · December 1988 The large copy number of rRNA makes it an appealing target for oligonucleotide probes designed to identify microorganisms. Given that nucleotide sequences in rRNA are known to reflect phylogeny, species-specific rRNA probes should be feasible if the sequen ... Full text Link to item Cite

Role of competition for nutrients in suppression of Clostridium difficile by the colonic microflora.

Journal Article Infect Immun · October 1988 The cecal flora of mice is able to eliminate Clostridium difficile from the mouse cecum even when C. difficile is the first organism established. We used a continuous-flow (CF) culture model of the cecal flora to investigate the possibility that competitio ... Full text Link to item Cite

Acquisition of Clostridium difficile from the hospital environment.

Journal Article Am J Epidemiol · June 1988 An outbreak of antibiotic-associated colitis that occurred on a ward of a Michigan hospital during February-April, 1984, was studied by bacteriophage-bacteriocin typing. Stools from the seven involved patients yielded Clostridium difficile isolates of type ... Full text Link to item Cite

Suppression of potential pathogens by a defined colonic microflora

Journal Article Microbial Ecology in Health and Disease · January 1, 1988 Animals acquiring a microflora for the first time do so through the gradual process of ecologic succession. A defined microflora was derived by experimentally simulating this process in gnotobiotic mice. Diverse bacterial species were obtained from ex-germ ... Full text Cite

Recurrent pseudobacteremias traced to a radiometric blood culture device.

Journal Article Infect Control · July 1987 Five clusters of pseudobacteremias over a seven-month period were traced to a BACTEC radiometric device. Four episodes were due to enterococcus and one involved Staphylococcus aureus. Each cluster began with multiple positive blood cultures from a patient ... Full text Link to item Cite

Emergence of nosocomial methicillin-resistant Staphylococcus aureus and therapy of colonized personnel during a hospital-wide outbreak.

Journal Article Infect Control · April 1987 At the Ann Arbor Veterans Administration Medical Center, 30 patients over a 6-month period became nosocomially infected or colonized by methicillin-resistant Staphylococcus aureus. Immediate institution of strict infection control measures, in conjunction ... Full text Link to item Cite

Interaction of Clostridium difficile and Escherichia coli with microfloras in continuous-flow cultures and gnotobiotic mice.

Journal Article Infect Immun · November 1986 We studied the interactions between the entire cecal flora of hamsters and the pathogens Clostridium difficile and Escherichia coli in gnotobiotic mice and in a continuous-flow (CF) culture system in which the growth medium consisted of an extract of fecal ... Full text Link to item Cite

Gnotobiotic models for study of the microbial ecology of Clostridium difficile and Escherichia coli.

Journal Article J Infect Dis · March 1986 Hamster flora introduced into germfree mice reduced the cecum to conventional size, suppressed populations of Escherichia coli and Clostridium difficile to the same degree that mouse flora did, and corrected the hypocellularity that is characteristic of th ... Full text Link to item Cite

Oral antibiotic therapy for osteomyelitis of the foot in diabetic patients.

Journal Article South Med J · February 1985 Although osteomyelitis of the foot in diabetic patients is generally considered a difficult infection to cure, the literature contains few reports comparing various treatment regimens. We have described two diabetic patients with osteomyelitis of the foot ... Full text Link to item Cite

Population dynamics of ingested Clostridium difficile in the gastrointestinal tract of the Syrian hamster.

Journal Article J Infect Dis · February 1985 The population dynamics of Clostridium difficile in the hamster gastrointestinal tract were studied after intragastric inoculation with organisms and a 51Cr tracer. Seventy-eight percent of spores germinated within the small intestine within 1 hr. Germinat ... Full text Link to item Cite

Efficiency of various bile salt preparations for stimulation of Clostridium difficile spore germination.

Journal Article J Clin Microbiol · October 1983 Taurocholate, desoxycholate, and cholate stimulated germination of Clostridium difficile spores in broth medium and enhanced recovery of C. difficile spores on a selective agar medium. Desoxycholate and some crude taurocholate preparations also inhibited m ... Full text Link to item Cite

Comparison of methods for recovery of Clostridium difficile from an environmental surface.

Journal Article J Clin Microbiol · August 1983 Survival of Clostridium difficile in an aerobic environment is possible because of spore formation. When sodium taurocholate is substituted for the egg yolk of a selective medium, cycloserine-cefoxitin-fructose-agar (CCFA), enhanced recovery of C. difficil ... Full text Link to item Cite

Antagonism of toxigenic Clostridium difficile by nontoxigenic C. difficile.

Journal Article J Infect Dis · April 1983 Cefoxitin-treated hamsters were first colonized with a nontoxigenic strain of Clostridium difficile, and then a toxigenic strain of C. difficile was administered. Toxigenic C. difficile was suppressed to a mean cecal population level of less than 0.2% of t ... Full text Link to item Cite

Persistent Strongyloides stercoralis in a blind loop of the bowel. Successful treatment with mebendazole.

Journal Article Arch Intern Med · February 1983 Three courses of thiabendazole therapy, including one course given directly into a blind loop of the bowel, failed to eradicate Strongyloides stercoralis from a 55-year-old man who had undergone a Roux-en-Y operation. The patient responded to 1.5 g/day of ... Full text Link to item Cite

133Xenon clearance from amniotic fluid in baboons during administration of oxytocin, prostaglandin F2 alpha and a beta-mimetic agent.

Journal Article Acta Obstet Gynecol Scand · 1983 Amniotic fluid clearance of 133xenon was measured in pregnant baboons near term during a control period of spontaneous uterine activity and during induction of contractions with oxytocin or PGF2 alpha and inhibition of activity by a beta-adrenergic agent, ... Full text Link to item Cite

Cervical priming prior to dilatation and evacuation: a comparison of methods.

Journal Article Am J Obstet Gynecol · December 15, 1982 Vaginal administration of prostaglandin analogues resulted in cervical changes that facilitated dilatation and evacuation in 80 patients in the late first trimester and the second trimester of pregnancy. When 0.5 mg and 1.0 mg of 15(S)-15-methyl-prostaglan ... Full text Link to item Cite

Fluorescent-antibody test for detection of Clostridium difficile in stool specimens.

Journal Article J Clin Microbiol · September 1982 We evaluated a direct fluorescent-antibody test to detect Clostridium difficile, the most frequent cause of antibiotic-associated colitis. C. difficile organisms were injected into the ear veins of New Zealand White rabbits to induce antibodies, and the gl ... Full text Link to item Cite

Use of sodium taurocholate to enhance spore recovery on a medium selective for Clostridium difficile.

Journal Article J Clin Microbiol · March 1982 Isolation of Clostridium difficile from fecal specimens has been facilitated by the development of a selective and differential medium, cefoxitin-cycloserinefructose agar (CCFA). We substituted 0.1% sodium taurocholate for the 2.5% egg yolk in CCFA and com ... Full text Link to item Cite

Suppression of Clostridium difficile by normal hamster cecal flora and prevention of antibiotic-associated cecitis.

Journal Article Infect Immun · November 1981 Administration of normal cecal homogenates decreased numbers of viable Clostridium difficile and prevented cecitis in antibiotic-challenged hamsters. Cecal anaerobes appeared to suppress C. difficile. ... Full text Link to item Cite

A new modality in nonstress testing: evaluation of beat-to-beat fetal heart rate variability.

Journal Article Am J Obstet Gynecol · November 1, 1981 Fetal monitoring equipment that provided accurate external measurement of the interval between each fetal heartbeat permitted the evaluation of beat-to-beat fetal heart rate (FHR) variability as part of routine nonstress testing. Nonstress tests (NSTs) wer ... Full text Link to item Cite

The inhibitory effect of ethanol on oxytocin-induced labor at term.

Journal Article J Reprod Med · November 1981 Intravenous ethanol infusion significantly reduced oxytocin-induced uterine activity in pregnant patients at term. The dose response to oxytocin was linear when plotted log2 x in all patients studied, and the line was shifted to the right by alcohol, but t ... Link to item Cite

A new abortion technique: intravaginal and intramuscular prostaglandin.

Journal Article Obstet Gynecol · July 1981 The 15-methyl analog of prostaglandin F2 alpha (15-ME-PGF2 alpha), administered in a 3-mg dose via a single vaginal suppository and supplemented at 24 hours by intramuscular injection(s) of 250 micrograms, successfully induced abortion in 80 of 81 patients ... Link to item Cite

Evaluation of eight cephalosporins in hamster colitis model.

Journal Article Antimicrob Agents Chemother · June 1981 Eight commonly used cephalosporins were evaluated in the hamster colitis mode. They were all found to cause hemorrhagic cecitis and death within 10 days of being given as subcutaneous or oral challenges. Necropsy findings were indistinguishable from clinda ... Full text Link to item Cite

Studies on the epidemiology of antibiotic-associated Clostridium difficile colitis.

Journal Article Am J Clin Nutr · November 1980 Vancomycin protects hamsters from the development of Clostridium difficile colitis after treatment with clindamycin, and vancomycin is useful in treatment of humans with the disease. Relapses have occurred in both hamsters and humans when vancomycin is dis ... Full text Link to item Cite

Management of intrauterine fetal death with prostaglandin E2 vaginal suppositories.

Journal Article Am J Obstet Gynecol · August 1, 1980 The recent Food and Drug Administration's approval of prostaglandin E2 (PGE2) vaginal suppositories provides the clinician with a technique for the immediate management of missed abortion and intrauterine fetal death (IUFD). During a 4-year period at our i ... Full text Link to item Cite

Pulmonary emboli 5 days postinjury presenting as fever of unknown origin.

Journal Article J Trauma · March 1980 A patient who fell on his right leg from a scaffold presented with fever of unknown etiology. Complete workup to rule out infectious causes for his fever was nonrevealing. Because of a history of transient episodes of dyspnea, lung scan was performed which ... Full text Link to item Cite

Early pregnancy interruption with two 15-ME-PGF2a suppositories.

Journal Article Contraception · March 1980 Vaginal administration of 15-ME-PGF2a suppositories successfully terminated pregnancy, as determined by a negative pregnancy test at 14 days following insertion, in 34 of 39 patients with gestations of 34 to 51 days of amenorrhea. Fifteen of 20 patients wh ... Full text Link to item Cite

Disseminated gonococcal infections (DGI).

Journal Article Cutis · December 1979 Neisseria gonorrhoeae infects superficial membranes of the eyes, oropharynx, genital tract, and rectum prior to dissemination. Gonococcal isolates cultured from patients with disseminated gonococcal infections (DGI) show resistance to serum bacteriolysis, ... Link to item Cite

The effects of intramuscular injections of 15(S)-15-methyl prostaglandin F2alpha in failed abortions.

Journal Article Fertil Steril · October 1977 Intramuscular injections of 15(S)-15-methyl prostaglandin F2alpha (15-Me-PGF2alpha) induced abortion in 38 patients who had failed to abort with other techniques, such as intra-amniotic instillation of saline or PGF2alpha and intravaginal insertion of pros ... Link to item Cite

Evaluation of danazol as an oral contraceptive.

Journal Article Obstet Gynecol · July 1977 The effect of Danazol as an oral contraceptive in doses of 50, 100, and 200 mg daily for 6 months was studied in 3 groups of 10 women. Both 50 and 100 mg Danazol daily were well tolerated, but one pregnancy occurred among the women receiving 50 mg daily, a ... Link to item Cite

Inhibition of premature labor: a multicenter comparison of ritodrine and ethanol.

Journal Article Am J Obstet Gynecol · April 15, 1977 A randomized controlled study was carried out at three medical centers to compare the efficacy and side effects of ethanol and ritodrine in the treatment of threatened premature labor. One hundred and thirty-five patients judged to be between the twentieth ... Full text Link to item Cite

The abortifacient and oxytocic effects of an intravaginal silicone rubber device containing a 0.5% concentration of 15(S)-15-methyl-prostaglandin F2alpha methyl ester.

Journal Article Am J Obstet Gynecol · April 1, 1977 Abortion was successfully induced by intravaginal insertion of a silicone rubber device impregnated with an 0.5% concentration of 15(S)-15-methyl-prostaglandin F2alpha methyl ester in 20 of 25 patients by prostaglandin alone and in an additional three pati ... Full text Link to item Cite

The effect of a 10 cm2, 0.5% 15-ME-PGF2alpha methyl ester intravaginal silastic device on abortion and plasma prostaglandin concentration.

Journal Article Prostaglandins · April 1977 Intravaginal insertion of a 10 cm2 silastic device with an 0.5% concentration of 15(S)-15-methyl-prostaglandin F2alpha methyl ester alone successfully induced abortion in 27 of 48 patients in the midtrimester and in an additional 11 patients with a concomi ... Full text Link to item Cite

Induction of labor in patients with missed abortion and fetal death in utero with protaglandin E2 suppositories.

Journal Article Am J Obstet Gynecol · March 15, 1977 Labor was successfully induced in 20 patients with a diagnosis of missed abortion or intrauterine fetal death (IUFD) by intravaginal administration of prostaglandin E2 suppositories. Fifteen patients delivered with the prostaglandin alone while a concomita ... Full text Link to item Cite

The abortifacient effectiveness and plasma prostaglandin concentrations with 15(S)-15-methyl prostaglandin F2alpha methyl ester-containing vaginal silastic devices.

Journal Article Fertil Steril · December 1976 The abortifacient effectiveness of three intravaginal Silastic devices impregnated with 15(S)-15-methyl prostaglandin F2alpha (15(S)-Me-PGF2alpha) methyl ester in concentrations of 0.25%, 0.5%, and 1.0% was investigated. Each concentration was tested in 10 ... Link to item Cite

The effect of danazol in the treatment of chronic cystic mastitis.

Journal Article Obstet Gynecol · July 1976 Danazol in a dose of 400 mg daily was administrated to 40 patients with chronic cystic mastitis and resulted in a marded improvement in both objective and subjective symptoms in 87.5% of the patients studied. Three patients showed partial relief of symptom ... Link to item Cite

Management of failed prostaglandin abortions.

Journal Article Obstet Gynecol · April 1976 Midtrimester abortion was induced in 529 patients by administration of the naturally occurring prostaglandins E2 and F2alpha as well as the 15-methyl analogs, 15-ME-PGE2 and 15-ME-PGF2alpha. Ten patients failed to abort with prostaglandin therapy, even in ... Link to item Cite

Luteolytic and abortifacient effects of serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha in early pregnancy.

Journal Article Am J Obstet Gynecol · February 15, 1976 Pregnancy was successfully terminated in 8 of 9 patients 5 to 6 weeks after the last menstrual period by serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha (15-ME-PGF2alpha). In one patient the treatment induced vaginal bleeding and a ... Full text Link to item Cite

Termination of midtrimester pregnancy by serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha.

Journal Article Am J Obstet Gynecol · January 15, 1976 Midtrimester abortion was successfully induced in 117 of 120 patients with serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha (15-me-PGF2alpha). The mean abortion time was 14.12 hours, and parous patients aborted in a mean of 12.85 ho ... Full text Link to item Cite

Hormone release and abortifacient effectiveness of a newly developed silastic device containing 15-ME-PGF2alpha methyl ester in concentrations of 0.5% and 1.0%.

Journal Article Prostaglandins · 1976 Abortion was successfully induced by intravaginal administration of a newly developed silastic device impregnated with 15(S)-15-methyl-prostaglandin F2alpha methyl ester in a concentration of 0.5% in 26 of 35 women in the 12th to the 24th weeks of gestatio ... Link to item Cite

Serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha in the induction of abortion.

Journal Article Prostaglandins · December 1975 Abortion was successfully induced in 62 of 68 patients in the 9th to the 26th week of pregnancy be serial intramuscular administration of 15(S)-15-methyl-prostaglandin F2alpha (15-ME-PGF2alpha). In 6 patients who failed to abort after 24 hours of prostagla ... Full text Link to item Cite

Midtrimester abortion induced by serial intramuscular injections of 15(S)-15-methyl-prostaglandin E2 methyl ester.

Journal Article Am J Obstet Gynecol · December 1, 1975 Midtrimester abortion was successfully induced in 29 of 30 patients with serial intramuscular injections of 15(S)-15-methyl-prostaglandin E2 methyl ester (15-ME-PGE2). The mean abortion time was 9.52 hours; parous patients aborted somewhat faster (mean, 8. ... Full text Link to item Cite

Danazol: an antigonadotropic agent in the treatment of pelvic endometriosis.

Journal Article Am J Obstet Gynecol · December 1, 1975 Danazol, an antigonadotropic agent, was administered in a dosage of 800 mg. daily for six months to 32 patients with pelvic endometriosis. Twenty-eight patients (87.5 per cent) were found to have a marked improvement of both clinical and subjective symptom ... Full text Link to item Cite

Induction of midtrimester abortion by serial intravaginal administration of 15(S)-15-methyl-prostaglandin F2alpha (THAM) suppositories.

Journal Article Prostaglandins · December 1975 Midtrimester abortion was successfully induced in 13 of 22 patients by serial intravaginal administration of 15(S)-15-methyl-prostaglandin F2alpha (THAM) suppositories. Nine patients, 4 nulliparas and 5 multiparas, failed to abort after 24 hours of prostag ... Full text Link to item Cite

Mid-trimester abortion induced by intravaginal administration of prostaglandin E2 suppositories.

Journal Article Am J Obstet Gynecol · August 15, 1975 Mid-trimester abortion was successfully induced in 70 of 71 patients by administration of vaginal PGE2 suppositories. The one patient who failed to abort with this method was pregnant in the blind horn of a duplex uterus. The mean abortion time for the suc ... Full text Link to item Cite

Midtrimester abortion induced by serial intravaginal administration of prostaglandin E2 suppositories in conjunction with a contraceptive diaphragm.

Journal Article Prostaglandins · July 1975 Midtrimester abortion was successfully induced in 68 of 69 patients with serial intravaginal administration of prostaglandin E2 suppositories behind a contraceptive diaphragm. The mean abortion time for the successful inductions was 13.07 hours; multiparou ... Full text Link to item Cite

Midtrimester abortion induced by single intra-amniotic instillation of two dose schedules of 15(S)-15-methyl-prostaglandin F2alpha.

Journal Article Prostaglandins · April 1975 Midtrimester abortion was successfully induced in a series of 20 patient by intraamniotic instillation of 15(S)-15-methyl-prostaglandin F2alpha with a mean abortion time of 17.78 hours. The patients in this study was divided into two groups, Groups 1 recei ... Full text Link to item Cite

The effect of berotec (Th 1165a) on spontaneous and induced uterine activity in the pregnant baboon.

Journal Article Am J Obstet Gynecol · March 1, 1975 Berotec (Th 1165a), a specific beta-adrenergic agent, has been found to be a more potent agent than metaproterenol in the inhibition of uterine activity in animals and human beings. The effect of berotec on spontaneous (postinduced) and induced uterine act ... Full text Link to item Cite

Midtrimester abortion induced by serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha.

Journal Article Am J Obstet Gynecol · January 15, 1975 Midtrimester abortion was successfully induced in 35 patients by serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha. The dose schedule in this series was an initial injection of 250 mug of 15-ME-PGF2alpha followed by another 250 mug i ... Full text Link to item Cite

Induction of labor with oral prostaglandin E2.

Journal Article Obstet Gynecol · December 1974 Link to item Cite

The effect of ethyl alcohol on isolated human myometrium.

Journal Article Am J Obstet Gynecol · June 1, 1969 Full text Link to item Cite

The inhibitory effect of diazoxide in normal term labor.

Journal Article Am J Obstet Gynecol · February 1, 1969 Full text Link to item Cite

Relaxant effect of diazepam on uterine muscle.

Journal Article Obstet Gynecol · October 1965 Link to item Cite

Uterine relaxant properties of bradykinin in vitro.

Journal Article Obstet Gynecol · July 1963 Link to item Cite

Postpartum immunization. Report of a study.

Journal Article Obstet Gynecol · December 1962 Link to item Cite