Journal ArticlePublic Health · August 2024
OBJECTIVES: COVID-19 revealed major shortfalls in healthcare workers (HCWs) trained in acute and critical care worldwide, especially in low-resource settings. We aimed to assess mass online courses' efficacy in preparing HCWs to manage COVID-19 patients an ...
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Journal ArticleJ Health Popul Nutr · June 20, 2024
BACKGROUND: Childhood obesity and hypertension are growing concerns globally, especially in developing countries. This study investigated the association between overall and central obesity at baseline, and prehypertension or hypertension at follow-up amon ...
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Journal ArticlePLOS Digit Health · May 2024
Research on the applications of artificial intelligence (AI) tools in medicine has increased exponentially over the last few years but its implementation in clinical practice has not seen a commensurate increase with a lack of consensus on implementing and ...
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Journal ArticleNPJ Digit Med · April 9, 2024
When integrating AI tools in healthcare settings, complex interactions between technologies and primary users are not always fully understood or visible. This deficient and ambiguous understanding hampers attempts by healthcare organizations to adopt AI/ML ...
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Journal ArticleJ Clin Hypertens (Greenwich) · April 2024
Hypertension is a leading risk factor for cardiovascular disease in South Asia. The authors aimed to assess the cross-country differences in 24-h ambulatory, daytime, and nighttime systolic blood pressure (SBP) among rural population with uncontrolled clin ...
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Journal ArticleJ Am Coll Cardiol · March 5, 2024
Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular conditions that frequently coexist. Among patients with HF, more than one-half also have AF. Both are associated with significant morbidity and mortality. Moreover, the prevalence of ...
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Journal ArticleCurr Probl Cardiol · March 2024
BACKGROUND: Generative Artificial Intelligence (AI) tools have experienced rapid development over the last decade and are gaining increasing popularity as assistive models in academic writing. However, the ability of AI to generate reliable and accurate re ...
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Journal ArticleHosp Top · 2024
Telemedicine is utilized to deliver health care services remotely. TM gained popularity as a result of pandemics, it can help the patients to get required medical care while sitting in the comfortable environment of their homes. In the future, it will cont ...
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Journal ArticleTrauma Surg Acute Care Open · 2024
INTRODUCTION: Older populations, being a unique subset of patients, have poor outcomes for emergency general surgery (EGS). In regions lacking specialized medical coverage for older patients, disparities in healthcare provision lead to poor clinical outcom ...
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Journal ArticleCurr Probl Cardiol · December 2023
BACKGROUND: Inadequate sleep duration and poor sleep quality are associated with adverse cardiovascular outcomes. METHODS: Using data from the National Health Interview Survey, we compared self-reported sleep duration and quality among different groups: Wh ...
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Journal ArticleCurr Cardiol Rep · December 2023
PURPOSE OF REVIEW: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. CVDs contribute to a large health and economic burden on a global scale. We aim to describe the current landscape of global cardiovascular research, ...
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Journal ArticleBMJ Open · November 19, 2023
INTRODUCTION: Atherosclerotic cardiovascular disease (ASCVD) is a major cause of morbidity, mortality and health expenditures worldwide. Despite having higher ASCVD in the Pakistani population, data on subclinical coronary atherosclerosis in young Pakistan ...
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Journal ArticleInt J Cardiol · October 1, 2023
BACKGROUND: Ischemic heart disease (IHD) is a major contributor to mortality in low-and middle-income-countries (LMICs). However, trends in IHD in females in LMICs are not well described. METHODS: We analyzed the Global Burden of Disease (GBD) Study from 1 ...
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Journal ArticleBMJ Open · September 21, 2023
OBJECTIVE: Data are essential for tracking and monitoring of progress on health-related sustainable development goals (SDGs). But the capacity to analyse subnational and granular data is limited in low and middle-income countries. Although Pakistan lags be ...
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Journal ArticleCurr Atheroscler Rep · September 2023
PURPOSE OF REVIEW: In this narrative review, we highlight different ways in which the COVID-19 pandemic has impacted coronary heart disease (CHD) burden and how a surge in morbidity and mortality may be expected in the near future. We also discuss potentia ...
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Journal ArticlePilot Feasibility Stud · July 17, 2023
BACKGROUND: The school environment plays an essential role in promoting health education and physical activity for children and adolescents. We aim to assess the feasibility of threefold health education program in children and its potential efficacy on ph ...
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Journal ArticlePublic Health · August 2024
OBJECTIVES: COVID-19 revealed major shortfalls in healthcare workers (HCWs) trained in acute and critical care worldwide, especially in low-resource settings. We aimed to assess mass online courses' efficacy in preparing HCWs to manage COVID-19 patients an ...
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Journal ArticleJ Health Popul Nutr · June 20, 2024
BACKGROUND: Childhood obesity and hypertension are growing concerns globally, especially in developing countries. This study investigated the association between overall and central obesity at baseline, and prehypertension or hypertension at follow-up amon ...
Full textLink to itemCite
Journal ArticlePLOS Digit Health · May 2024
Research on the applications of artificial intelligence (AI) tools in medicine has increased exponentially over the last few years but its implementation in clinical practice has not seen a commensurate increase with a lack of consensus on implementing and ...
Full textLink to itemCite
Journal ArticleNPJ Digit Med · April 9, 2024
When integrating AI tools in healthcare settings, complex interactions between technologies and primary users are not always fully understood or visible. This deficient and ambiguous understanding hampers attempts by healthcare organizations to adopt AI/ML ...
Full textLink to itemCite
Journal ArticleJ Clin Hypertens (Greenwich) · April 2024
Hypertension is a leading risk factor for cardiovascular disease in South Asia. The authors aimed to assess the cross-country differences in 24-h ambulatory, daytime, and nighttime systolic blood pressure (SBP) among rural population with uncontrolled clin ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · March 5, 2024
Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular conditions that frequently coexist. Among patients with HF, more than one-half also have AF. Both are associated with significant morbidity and mortality. Moreover, the prevalence of ...
Full textLink to itemCite
Journal ArticleCurr Probl Cardiol · March 2024
BACKGROUND: Generative Artificial Intelligence (AI) tools have experienced rapid development over the last decade and are gaining increasing popularity as assistive models in academic writing. However, the ability of AI to generate reliable and accurate re ...
Full textLink to itemCite
Journal ArticleHosp Top · 2024
Telemedicine is utilized to deliver health care services remotely. TM gained popularity as a result of pandemics, it can help the patients to get required medical care while sitting in the comfortable environment of their homes. In the future, it will cont ...
Full textLink to itemCite
Journal ArticleTrauma Surg Acute Care Open · 2024
INTRODUCTION: Older populations, being a unique subset of patients, have poor outcomes for emergency general surgery (EGS). In regions lacking specialized medical coverage for older patients, disparities in healthcare provision lead to poor clinical outcom ...
Full textLink to itemCite
Journal ArticleCurr Probl Cardiol · December 2023
BACKGROUND: Inadequate sleep duration and poor sleep quality are associated with adverse cardiovascular outcomes. METHODS: Using data from the National Health Interview Survey, we compared self-reported sleep duration and quality among different groups: Wh ...
Full textLink to itemCite
Journal ArticleCurr Cardiol Rep · December 2023
PURPOSE OF REVIEW: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. CVDs contribute to a large health and economic burden on a global scale. We aim to describe the current landscape of global cardiovascular research, ...
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Journal ArticleBMJ Open · November 19, 2023
INTRODUCTION: Atherosclerotic cardiovascular disease (ASCVD) is a major cause of morbidity, mortality and health expenditures worldwide. Despite having higher ASCVD in the Pakistani population, data on subclinical coronary atherosclerosis in young Pakistan ...
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Journal ArticleInt J Cardiol · October 1, 2023
BACKGROUND: Ischemic heart disease (IHD) is a major contributor to mortality in low-and middle-income-countries (LMICs). However, trends in IHD in females in LMICs are not well described. METHODS: We analyzed the Global Burden of Disease (GBD) Study from 1 ...
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Journal ArticleBMJ Open · September 21, 2023
OBJECTIVE: Data are essential for tracking and monitoring of progress on health-related sustainable development goals (SDGs). But the capacity to analyse subnational and granular data is limited in low and middle-income countries. Although Pakistan lags be ...
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Journal ArticleCurr Atheroscler Rep · September 2023
PURPOSE OF REVIEW: In this narrative review, we highlight different ways in which the COVID-19 pandemic has impacted coronary heart disease (CHD) burden and how a surge in morbidity and mortality may be expected in the near future. We also discuss potentia ...
Full textLink to itemCite
Journal ArticlePilot Feasibility Stud · July 17, 2023
BACKGROUND: The school environment plays an essential role in promoting health education and physical activity for children and adolescents. We aim to assess the feasibility of threefold health education program in children and its potential efficacy on ph ...
Full textLink to itemCite
Journal ArticleCurr Probl Cardiol · July 2023
Identifying Asian subgroups with higher risk of premature coronary heart disease (CHD) can help implement targeted strategies to prevent future CHD events. We conducted this National Health Interview Survey study from 2006 to 2015 among participants with h ...
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Journal ArticleClin Hypertens · June 15, 2023
BACKGROUND: This review aims to describe existing evidence on the state of hypertension in Pakistan, including the prevalence, associated risk factors, preventive strategies, and challenges in the management of hypertension. METHODS: A comprehensive litera ...
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Journal ArticleAm Heart J · June 2023
BACKGROUND: Limited data exists regarding the relationships between resource use and outcomes in patients with mitral regurgitation (MR). We examined resource utilization and outcomes across MR type and severity. METHODS: Using the Duke Echocardiography La ...
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Journal ArticleCurr Atheroscler Rep · June 2023
PURPOSE OF REVIEW: To summarize selected late-breaking science on cardiovascular (CV) disease prevention presented at the 2023 American College of Cardiology (ACC) conference. RECENT FINDINGS: The CLEAR outcomes randomized control trial (RCT) compared bemp ...
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Journal ArticleBMC Public Health · May 5, 2023
BACKGROUND: Cervical cancer is a major cause of cancer-related deaths among women worldwide. Paucity of data on cervical cancer burden in countries like Pakistan hamper requisite resource allocation. OBJECTIVE: To estimate the burden of cervical cancer in ...
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Journal ArticleJ Hum Hypertens · April 2023
Women have been reported to be at greater risk of left ventricular hypertrophy (LVH) than men in South Asia, but whether the sex disparity is affected by central obesity and blood pressure has not been well studied. We examined prospectively the interactio ...
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Journal ArticleAm J Cardiol · February 1, 2023
There is a scarcity of data on gender differences in outcomes during and after percutaneous coronary intervention (PCI) in the South Asian population. We assessed the gender differences in in-hospital mortality and complications in patients who underwent P ...
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Journal ArticleLancet Glob Health · February 2023
BACKGROUND: Understanding health trends and estimating the burden of disease at the national and subnational levels helps policy makers track progress and identify disparities in overall health performance. The Global Burden of Diseases, Injuries, and Risk ...
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Chapter · January 1, 2023
PCOS patients have a higher prevalence of traditional risk factors for cardiovascular disease (CVD), and insulin resistance significantly contributes to the pathogenesis of these risk factors. Although central obesity has been reported to potentiate athero ...
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Journal ArticleProg Cardiovasc Dis · 2023
INTRODUCTION: Familial hypercholesterolemia (FH) is a modifiable risk factor for premature coronary heart disease but is poorly diagnosed and treated. We leveraged a large laboratory network in Pakistan to study the prevalence, gender and geographic distri ...
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Journal ArticlePLoS One · 2023
INTRODUCTION: Medical colleges globally have student organizations that serve to enable students' involvement in research. However, details of their approach and activities are seldom published to serve as learning for student organizations in other settin ...
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Journal ArticleBMJ Open · December 19, 2022
INTRODUCTION: Most of the global non-communicable disease (NCD)-related death burden is borne by low and middle-income countries (LMICs). In LMICs like Pakistan, however, a major gap in responding to NCDs is a lack of high-quality research leading to polic ...
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Journal ArticleCurr Probl Cardiol · December 2022
Vaccination coverage rates across Asian American subpopulations with atherosclerotic cardiovascular disease (ASCVD) and diabetes mellitus is not well-studied. We used data from the National Health Interview Survey (NHIS) from 2006 to 2018 and included part ...
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Journal ArticlePrev Med Rep · October 2022
INTRODUCTION: Prior studies have shown a direct association between U.S. birth and duration of residence with atherosclerotic cardiovascular disease (ASCVD) though, few have specifically focused on Asian Americans. METHODS: We utilized cross-sectional data ...
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Journal ArticleAnn Intern Med · September 2022
BACKGROUND: Left atrial appendage occlusion (LAAO) is a potential alternative to oral anticoagulants in selected patients with atrial fibrillation (AF). Compared with anticoagulants, LAAO decreases major bleeding risk, but there is uncertainty regarding th ...
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Journal ArticleInt J Cardiol Cardiovasc Risk Prev · September 2022
BACKGROUND: Differences in prevalence of risk factors such as hypertension may explain heterogeneity in cardiovascular risk across Asian American populations. METHODS: We used National Health Interview Survey (NHIS) data from 2006 to 2018 among White, Chin ...
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Journal ArticleJ Am Heart Assoc · August 2, 2022
Background Social and environmental factors play an important role in the rising health care burden of cardiovascular disease. The Centers for Disease Control and Prevention developed the Social Vulnerability Index (SVI) from US census data as a tool for p ...
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Journal ArticleCrit Care · July 11, 2022
BACKGROUND: In response to the COVID-19 pandemic, concerted efforts were made by provincial and federal governments to invest in critical care infrastructure and medical equipment to bridge the gap of resource-limitation in intensive care units (ICUs) acro ...
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Journal ArticleEur Heart J · May 1, 2022
AIMS: Mitral valve prolapse (MVP) is a common valvular heart disease with a prevalence of >2% in the general adult population. Despite this high incidence, there is a limited understanding of the molecular mechanism of this disease, and no medical therapy ...
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Journal ArticleJAMA Cardiol · March 1, 2022
IMPORTANCE: There are limited data regarding sex-based differences in physical and mental health domains and health care access in adults with premature atherosclerotic cardiovascular disease (ASCVD). OBJECTIVE: To study the association of sex with physica ...
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Journal ArticleCardiol J · 2022
BACKGROUND: Many patients in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) had a significant improvement (> 10%) in the left ventricular ejection fraction (LVEF) during the course of the study, but the factors and outcomes associated with such ...
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Journal ArticleGlob Heart · 2022
BACKGROUND AND OBJECTIVE: Few data exist on trends in acute myocardial infarction (AMI) patterns spanning recent epidemiological shifts in low middle-income countries (LMICs). To understand temporal disease patterns of AMI characteristics and outcomes betw ...
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Journal ArticleFront Cardiovasc Med · 2022
INTRODUCTION: Hypertension is an important contributor to cardiovascular disease related morbidity and mortality. Despite the magnitude of its negative impact on cardiovascular outcomes, treatment and control of hypertension remain suboptimal in both men a ...
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Journal ArticleProg Cardiovasc Dis · 2022
South Asians account for around 25% of the global population and are the fastest-growing ethnicity in the US. This population has an increasing burden of atherosclerotic cardiovascular disease (ASCVD) which is also seen in the diaspora. Current risk predic ...
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Journal ArticleCurr Cardiol Rep · October 23, 2021
PURPOSE OF REVIEW: To revisit the importance of prevention strategies and policies in reducing the burden of ischemic heart disease in South Asian countries. RECENT FINDINGS: South Asia has seen rapid growth in its population with variable improvement in h ...
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Journal ArticleJAMA Cardiol · July 1, 2021
IMPORTANCE: There is a paucity of data regarding secondary prevention care disparities in women with premature and extremely premature atherosclerotic cardiovascular disease (ASCVD), defined as an ASCVD event at 55 years or younger and 40 years or younger, ...
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Journal ArticleAm Heart J · April 2021
BACKGROUND: Among patients with severe aortic stenosis (AS), there are limited data on aortic valve replacement (AVR), reasons for nonreceipt and mortality by race. METHODS: Utilizing the Duke Echocardiography Laboratory Database, we analyzed data from 110 ...
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Journal ArticleHeart · April 2021
OBJECTIVE: Despite an upsurge in the incidence of atherosclerotic cardiovascular diseases (ASCVD) among young adults, the attributable risk of recreational substance use among young patients has been incompletely evaluated. We evaluated the association of ...
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Journal ArticleKidney Int Rep · April 2021
INTRODUCTION: The creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimated glomerular filtration rate (eGFR) equation was calibrated for the general Pakistan population (eGFRcr-PK) to eliminate bias and improve accuracy. Cysta ...
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Journal ArticleCirculation · February 23, 2021
BACKGROUND: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, ...
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Journal ArticleGlob Heart · January 18, 2021
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. Health research is crucial to managing disease burden. Previous work has highlighted marked discrepancies in research output and disease burden between high-in ...
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Journal ArticleAsia Pac J Public Health · January 2021
Hypertension is highly prevalent, but its pharmacological management has not been well evaluated in low- and middle-income countries (LMICs). This review examined the prescribing patterns of antihypertensives in LMICs. Data were extracted from a total of 2 ...
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Journal ArticleGlob Heart · 2021
AIMS: To identify the changes in cardiovascular disease presentation, emergency room triage and inpatient diagnostic and therapeutic pathways. METHODS: We conducted a retrospective cohort study at the Aga Khan University Hospital, Karachi. We collected dat ...
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Journal ArticleAm J Cardiol · December 15, 2020
Left bundle branch block (LBBB) increases the likelihood of developing reduced left ventricular (LV) ejection fraction (EF) but predicting which patients with LBBB and normal LVEF will develop decreased LVEF remains challenging. Fifty patients with LBBB an ...
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Journal ArticleAm J Med · December 2020
BACKGROUND: Although the association between autoimmune rheumatic diseases and atherosclerotic cardiovascular disease is well-known, there is a lack of data regarding the role of such disorders in patients with premature and extremely premature atheroscler ...
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Journal ArticleEast Mediterr Health J · October 13, 2020
BACKGROUND: Muslim majority countries have experienced a considerable burden of COVID-19 infection. However, there has been a relative lack of research comparing COVID-19 outbreaks and responses between Muslim-majority countries. AIMS: This study aimed to ...
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Journal ArticleJ Nucl Cardiol · October 2020
BACKGROUND: Prevalence and prognostic value of diastolic and systolic dyssynchrony in patients with coronary artery disease (CAD) + heart failure (HF) or CAD alone are not well understood. METHODS: We included patients with gated single-photon emission com ...
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Journal ArticleJAMA Netw Open · August 3, 2020
IMPORTANCE: Studies on the use of and adherence to secondary prevention therapies in patients with premature and extremely premature atherosclerotic cardiovascular disease (ASCVD) are lacking. OBJECTIVE: To evaluate and compare aspirin use, any statin use, ...
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Journal ArticleCurr Atheroscler Rep · July 16, 2020
PURPOSE OF REVIEW: In contrast to patients with non-premature atherosclerotic cardiovascular disease (ASCVD), patients with premature ASCVD have not observed a similar decline in cardiovascular mortality and recurrent adverse events. We sought to review th ...
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Journal ArticleMetab Syndr Relat Disord · June 2020
Background: We aimed to assess the burden of metabolic syndrome (MetS), and evaluate the phenotypic variation of MetS in a population at high risk for diabetes in urban Karachi, Pakistan. Methods: This study was embedded in a lifestyle intervention trial f ...
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Journal ArticleInt J Emerg Med · May 14, 2020
BACKGROUND: The burden of trauma-related-out-of-hospital cardiac arrest (OHCA) in developing countries like Pakistan remains largely unexplored due to a lack of organized pre-hospital systems. In order to estimate the burden, we used a two-sample capture-r ...
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Journal ArticleAm Heart J · March 2020
BACKGROUND: Statin use remains suboptimal in patients with atherosclerotic cardiovascular disease (ASCVD). We assessed if the frequency of visits with primary care providers (PCPs) is associated with higher use of evidence-based statin prescriptions and ad ...
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Journal ArticleCirculation · February 18, 2020
Cardiovascular disease (CVD) is the leading cause of death among women in the United States. As compared with men, women are less likely to be diagnosed appropriately, receive preventive care, or be treated aggressively for CVD. Sex differences between men ...
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Journal ArticleIndian Heart J · 2020
Several registries and quality improvement initiatives have focused on assessing and improving secondary prevention of CVD in India. While the Treatment and Outcomes of Acute Coronary Syndromes in India (CREATE), Indian Heart Rhythm Society-Atrial Fibrilla ...
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Journal ArticleJournal of Global Health Reports · November 1, 2019
The Middle East, Mediterranean, Africa (MEMA) region, is composed of 68 countries, totalling a population of over 1.6 billion ie, 20% of the world. It contributes little to the international effort of health knowledge production, hosting only 6% of the wor ...
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Journal ArticleAm J Cardiol · October 15, 2019
Echocardiography is a key tool in the management of patients with pulmonary arterial hypertension (PAH), but many potential parameters could be used to assess response to therapy. In this retrospective study of 48 patients with severe PAH at baseline, we e ...
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ConferenceJACC Cardiovasc Imaging · July 2019
OBJECTIVES: The goal of this study was to examine whether diastolic dyssynchrony, measured by using gated single-photon emission computed tomography (GSPECT) myocardial perfusion imaging (MPI) in patients with coronary artery disease (CAD), is independentl ...
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Journal ArticleAm J Cardiol · March 1, 2019
The introduction of transcatheter aortic valve implantation (TAVI) has revolutionized the treatment of patients with severe aortic stenosis (AS). However, despite the great clinical success of TAVI, less is known about the cardiac hemodynamics and structur ...
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Journal ArticleInt J Cardiovasc Imaging · November 2018
Quality in stress echocardiography interpretation is often gauged against coronary angiography (CA) data but anatomic obstructive coronary disease on CA is an imperfect gold standard for a stress induced wall motion abnormality. We examined the utility of ...
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Journal ArticleCirc Cardiovasc Imaging · November 2018
Background Although right atrial (RA) enlargement is an established marker for adverse outcomes, the prognostic importance of RA dysfunction independent of RA size in pulmonary arterial hypertension is not known. Methods and Results Study subjects with pul ...
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Journal ArticleAm Heart J · September 2018
BACKGROUND: We aimed to determine the association of MR severity and type with all-cause death in a large, real-world, clinical setting. METHODS: We reviewed full echocardiography studies at Duke Echocardiography Laboratory (01/01/1995-12/31/2010), classif ...
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Journal ArticleAm J Cardiol · September 1, 2018
In pulmonary hypertension (PH), measurement of various echocardiographic parameters that assess right heart function is recommended by current clinical guidelines. Limited data exists on the combined value of clinical and echocardiographic parameters in pr ...
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Journal ArticleJ Am Soc Echocardiogr · June 2018
BACKGROUND: Right ventricular peak systolic longitudinal strain (RVLS) has emerged as an approach for quantifying right ventricular function in diseases such as pulmonary hypertension and congenital heart disease. A major limitation in applying RVLS is tha ...
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Journal ArticleJ Am Coll Cardiol · January 23, 2018
BACKGROUND: Patients with left bundle branch block (LBBB) often respond to cardiac resynchronization therapy (CRT) with left ventricular ejection fraction (LVEF) improvement. Guideline-directed medical therapy (GDMT), not CRT, is first-line therapy for pat ...
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Journal ArticleIndian Heart J · 2018
South Asia has experienced a 73% increase in healthy life years lost due to ischemic heart disease between 1990 and 2010. There is a lack of quality data relating to cardiovascular risk factors and disease from this region. Several observational and prospe ...
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Chapter · January 1, 2018
Measurement of myocardial global longitudinal strain (GLS) is no longer a research tool. Rather, GLS is now used for risk assessment and management of patients with a wide variety of clinical disorders. GLS is clearly a useful supplement to routine quantit ...
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Journal ArticleAm J Cardiol · December 1, 2017
We compared the incidence of left ventricular systolic dysfunction (LVSD) among patients with left bundle branch block (LBBB) to a matched cohort of patients with a narrow QRS duration <120 ms (NQRS). We hypothesized patients with preserved ejection fracti ...
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Journal ArticleAm J Cardiol · November 1, 2017
Mental stress-induced myocardial ischemia is common and a prognostic factor of adverse cardiovascular outcomes in patients with coronary artery disease (CAD). The present study aimed at examining associations between mental stress-induced myocardial annula ...
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Journal ArticleJ Am Heart Assoc · October 11, 2017
BACKGROUND: Chronic kidney disease (CKD) is an adverse prognostic marker for valve intervention patients; however, the prevalence and related outcomes of valvular heart disease in CKD patients is unknown. METHODS AND RESULTS: Included patients underwent ec ...
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Journal ArticleInt J Cardiovasc Imaging · September 2017
This retrospective study evaluated the diagnostic characteristics of a combination of echocardiographic parameters for pulmonary hypertension (PH). Right ventricular systolic pressure (RVSP) estimation by echocardiography (echo) is used to screen for PH. H ...
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Journal ArticleJ Cardiothorac Vasc Anesth · August 2017
OBJECTIVES: Determine whether moderate or greater paravalvular leak (PVL) after transcatheter aortic valve replacement quantified using intraoperative transesophageal echocardiography (TEE) is associated with mortality and investigate the correlation betwe ...
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Journal ArticleJ Cardiothorac Vasc Anesth · June 2017
OBJECTIVE: Progression of mitral regurgitation (MR) after orthotopic lung transplantation (OLT) may be an underrecognized phenomenon due to the overlapping symptomatology of pulmonary and valvular disease. Literature evaluating the progression of MR after ...
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Journal ArticleEur J Prev Cardiol · April 2017
Aims Mental stress-induced myocardial ischemia (MSIMI) occurs in up to 70% of patients with clinically stable ischemic heart disease and is associated with increased risk of adverse prognosis. We aimed to examine the prognostic value of indices of MSIMI an ...
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Journal ArticleAm J Cardiol · April 1, 2017
The utility of routine transesophageal echocardiography (TEE) to exclude left atrial appendage (LAA) thrombus before atrial fibrillation (AF) ablation in patients treated with nonvitamin K oral anticoagulant (NOAC) therapy is unclear. This single-center re ...
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Journal ArticleJ Psychosom Res · February 2017
OBJECTIVE: Depressive symptoms have been associated with myocardial ischemia induced by mental (MSIMI) and exercise (ESIMI) stress in clinically stable ischemic heart disease (IHD) patients, but the association between positive emotions and inducible ische ...
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Journal ArticleSemin Respir Crit Care Med · February 2017
Acute pulmonary embolism (PE) is a major cause of morbidity and mortality and is classified as massive (high risk), submassive (intermediate risk), or nonmassive (low risk) based on the hemodynamic status and clinical characteristics of the patient. At thi ...
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Journal ArticleInt J Womens Health · 2017
Cardiovascular disease is the leading cause of death in women accounting for 1 in every 4 female deaths. Pathophysiology of ischemic heart disease in women includes epicardial coronary artery, endothelial dysfunction, coronary vasospasm, plaque erosion and ...
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Journal ArticleCurr Cardiol Rep · December 2016
Functional mitral regurgitation (MR) is the most common type of MR encountered in clinical practice. Because the disease arises from the ventricular aspect of the mitral valve apparatus, treatment therapies are less defined and outcomes are poor. In this r ...
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Journal ArticleJ Am Soc Echocardiogr · November 2016
BACKGROUND: Patients with systemic right ventricles frequently experience progressive heart failure and conduction abnormalities leading to abnormal ventricular activation. Activation delay-induced mechanical dyssynchrony can contribute to ventricular fail ...
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Journal ArticleCardiovasc Ultrasound · October 28, 2016
PURPOSE: The aim of this study was to evaluate the utility of adding quantitative assessments of cardiac function from echocardiography to clinical factors in predicting the outcome of patients with acute pulmonary embolism (PE). METHODS: Patients with a d ...
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Journal ArticleCardiovascular ultrasound · October 28, 2016
PURPOSE: The aim of this study was to evaluate the utility of adding quantitative assessments of cardiac function from echocardiography to clinical factors in predicting the outcome of patients with acute pulmonary embolism (PE). METHODS: Patients with a d ...
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Journal ArticleJ Cardiothorac Vasc Anesth · October 2016
OBJECTIVE: The authors hypothesized that average precardiopulmonary bypass (pre-CPB) transesophageal echocardiographic (TEE) mean gradient (PGm) and aortic valve area (AVA) values would be significantly different from preoperative transthoracic (TTE) value ...
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Journal ArticleEur Heart J · July 21, 2016
AIMS: We aimed to determine the frequency of aortic valve surgery (AVR) with or without coronary artery bypass grafting (CABG), among patients with moderate/severe aortic stenosis (AS) and left ventricular systolic dysfunction (LVSD), and its relationship ...
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Journal ArticleInt J Cardiovasc Imaging · July 2016
Echocardiography is essential for the diagnosis and management of infective endocarditis (IE). However, the reproducibility for the echocardiographic assessment of variables relevant to IE is unknown. Objectives of this study were: (1) To define the reprod ...
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Journal ArticleJ Am Soc Echocardiogr · April 2016
BACKGROUND: In patients with suspected native valve infective endocarditis, current guidelines recommend initial transthoracic echocardiography (TTE) followed by transesophageal echocardiography (TEE) if clinical suspicion remains. The guidelines do not ac ...
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Journal ArticleCirc Cardiovasc Imaging · March 2016
BACKGROUND: The management of aortic stenosis rests on accurate echocardiographic diagnosis. Hence, it was chosen as a test case to examine the utility of continuous quality improvement (CQI) approaches to increase echocardiographic data accuracy and relia ...
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Journal ArticleAm Heart J · November 2015
BACKGROUND: We compared 30-day and 1-year survival among high-risk mitral regurgitation (MR) patients treated with the MitraClip (Abbott Vascular, Abbott Park, IL) with matched non-surgically treated patients from the Duke Echocardiography Laboratory Datab ...
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Journal ArticleEur Heart J · October 21, 2015
AIMS: The management and outcomes of patients with functional moderate/severe mitral regurgitation and severe left ventricular (LV) systolic dysfunction are not well defined. We sought to determine the characteristics, management strategies, and outcomes o ...
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Journal ArticleCrit Pathw Cardiol · September 2015
BACKGROUND: Calcific aortic stenosis (AS) is the most common underlying pathology in patients undergoing heart valve surgery, with an expected increasing prevalence among the aging population. METHODS AND RESULTS: We identified the temporal trends in refer ...
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Journal ArticleAm Heart J · September 2015
OBJECTIVES: To evaluate the use of surrogate measures in pulmonary hypertension (PH) clinical trials and how it relates to clinical practice. BACKGROUND: Studies of pulmonary arterial hypertension (PAH) employ a variety of surrogate measures in addition to ...
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Journal ArticleCirc Cardiovasc Imaging · July 2015
BACKGROUND: Staphylococcus aureus left-sided native valve infective endocarditis (LNVIE) has higher complication and mortality rates compared with endocarditis from other pathogens. Whether echocardiographic variables can predict prognosis in S aureus LNVI ...
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Journal ArticleMetabolomics · June 1, 2015
Mental stress induced left ventricular dysfunction (LVD) has been associated with a greater risk of adverse events in coronary heart disease (CHD) patients independent of conventional risk indicators. The underlying biochemical mechanisms of this cardiovas ...
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Journal ArticleAntimicrob Agents Chemother · April 2015
Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and u ...
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Journal ArticleAm Heart J · April 2015
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is common in patients with ischemic heart disease (IHD) and associated with a poorer cardiovascular prognosis. Platelet hyperactivity is an important factor in acute coronary syndrome. This stud ...
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Journal ArticleAmerican Heart Journal · April 1, 2015
Background Mental stress-induced myocardial ischemia (MSIMI) is common in patients with ischemic heart disease (IHD) and associated with a poorer cardiovascular prognosis. Platelet hyperactivity is an important factor in acute coronary syndrome. This study ...
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Journal ArticleClin Infect Dis · March 1, 2015
BACKGROUND: The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the fir ...
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Journal ArticleInt J Cardiol · January 15, 2015
BACKGROUND: Nearly half of patients require cardiac surgery during the acute phase of infective endocarditis (IE). We describe the characteristics of patients according to the type of valve replacement (mechanical or biological), and examine whether the ty ...
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Journal ArticleAm J Cardiol · January 1, 2015
We aimed to characterize the hemodynamic progression of aortic stenosis (AS) in a contemporary unselected cohort of patients with preserved left ventricular ejection fraction. Current guidelines recommend echocardiographic surveillance of hemodynamic progr ...
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Journal ArticleJ Am Coll Cardiol · October 21, 2014
BACKGROUND: Although emotional stress is associated with ischemic heart disease (IHD) and related clinical events, sex-specific differences in the psychobiological response to mental stress have not been clearly identified. OBJECTIVES: We aimed to study th ...
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ConferenceIEEE International Ultrasonics Symposium, IUS · October 20, 2014
A new method of acquiring and displaying high speed ultrasound images has been developed. To extract flow information from the low intensity reflections of moving blood in these high frame rate images, difference imaging was found to be a particularly appl ...
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Journal ArticleAm Heart J · August 2014
UNLABELLED: The introduction of transcatheter aortic valve replacement (TAVR) in clinical practice has widened options for symptomatic patients at high surgical risk; however, it is not known whether TAVR has equivalent or prolonged benefits in terms of le ...
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Journal ArticleCirculation · June 17, 2014
BACKGROUND: The optimal treatment for ischemic mitral regurgitation remains actively debated. Our objective was to evaluate the relationship between ischemic mitral regurgitation treatment strategy and survival. METHODS AND RESULTS: We retrospectively revi ...
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Journal ArticleJ Am Soc Echocardiogr · June 2014
BACKGROUND: Right ventricular (RV) function is a strong predictor of mortality in pulmonary hypertension (PH), but two-dimensional (2D) echocardiography-derived assessments of RV function that could aid in risk assessment and management of patients with PH ...
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Journal ArticleEur J Cardiothorac Surg · June 2014
OBJECTIVES: Pulmonary hypertension is considered a poor prognostic factor for or even a contraindication to major lung resection, but evidence for this claim is lacking. This study evaluates the impact of pulmonary hypertension on morbidity and mortality f ...
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Journal ArticleJ Am Soc Echocardiogr · April 2014
BACKGROUND: Although quantitative right ventricular (RV) strain analysis may be useful in congenital and acquired heart disease populations with RV failure, a comprehensive, standardized approach is lacking. An 18-segment RV strain analysis obtained from t ...
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Journal ArticleJACC Cardiovasc Imaging · April 2014
OBJECTIVES: The aim of this study was to investigate the association between resting myocardial function as assessed by tissue Doppler myocardial velocities and the propensity to develop mental stress-induced ischemia (MSIMI). BACKGROUND: Tissue Doppler my ...
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Chapter · November 1, 2013
A complete and accurate assessment of the aortic annulus and the surrounding structures is accomplished non-invasively by on organized echocardiographic approch employing a variety of techniques. An approch with transthoracic and transesophageal imaging mo ...
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Journal ArticleJAMA · May 22, 2013
IMPORTANCE: Mental stress can induce myocardial ischemia and also has been implicated in triggering cardiac events. However, pharmacological interventions aimed at reducing mental stress-induced myocardial ischemia (MSIMI) have not been well studied. OBJEC ...
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Journal ArticleJ Am Coll Cardiol · February 19, 2013
OBJECTIVES: The goal of this study was to evaluate the prevalence and clinical characteristics of mental stress-induced myocardial ischemia. BACKGROUND: Mental stress-induced myocardial ischemia is prevalent and a risk factor for poor prognosis in patients ...
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Journal ArticleClin Infect Dis · January 2013
BACKGROUND: The timing of cardiac surgery after stroke in infective endocarditis (IE) remains controversial. We examined the relationship between the timing of surgery after stroke and the incidence of in-hospital and 1-year mortalities. METHODS: Data were ...
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Journal ArticleJ Electrocardiol · 2013
BACKGROUND: Patients with ostium secundum atrial septal defects (ASDs) were studied to determine the prevalence of Selvester anteroseptal myocardial infarction QRS points, and to test the hypothesis that there is a relationship between these criteria and t ...
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Journal ArticlePLoS One · 2013
The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics a ...
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Journal ArticlePsychosom Med · 2013
OBJECTIVES: The aim of this study was to examine the associations between depressive symptoms and mental stress-induced myocardial ischemia (MSIMI) in patients with coronary heart disease (CHD). METHODS: Adult patients with documented CHD were recruited fo ...
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Journal ArticleAm J Cardiol · November 1, 2012
Mitral valve prolapse may involve 1 leaflet or 2 leaflets, yet management guidelines do not differentiate posterior leaflet (PML) from bileaflet (BML) prolapse. We hypothesized that patients with BML have a prolonged natural history with more severe atrial ...
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Journal ArticleJ Am Soc Echocardiogr · November 2012
BACKGROUND: Evaluation of myocardial deformation by two-dimensional speckle-tracking is useful for clinical and research purposes. However, differences may exist among different ultrasound machines, software packages, frame rates, and observers. METHODS: T ...
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Journal ArticleJ Nucl Cardiol · April 2012
BACKGROUND: To assess clinical utility of computed tomography angiography (CTA) in the diagnosis of chest pain patients presenting to emergency departments (EDs), we conducted a meta-analysis of CTA in patients with suspected acute coronary syndromes (ACSs ...
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Journal ArticleJ Cardiothorac Vasc Anesth · February 2012
OBJECTIVE: The authors hypothesized that the measurement of strain by speckle tracking with transesophageal echocardiography (TEE) is feasible and comparable to transthoracic echocardiography (TTE). DESIGN: A prospective observational comparative study. SE ...
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Journal ArticleAm Heart J · January 2012
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is common in patients with clinically stable coronary heart disease (CHD) and is associated with poor outcomes. Depression is a risk factor of MSIMI. The REMIT trial investigates whether selecti ...
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Journal ArticleJ Nucl Cardiol · February 2011
BACKGROUND: A novel method to quantify dyssynchrony using phase analysis of single-photon emission computed tomography (SPECT) myocardial perfusion imaging has been developed. We sought to determine the prevalence of SPECT-derived mechanical dyssynchrony, ...
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Journal ArticleHeart · February 2011
BACKGROUND: Optimal timing of surgery in degenerative mitral regurgitation (MR) remains a controversial topic. The impact of current ACC/AHA guideline recommendations about optimal timing of surgery on outcomes is untested and contemporary data are lacking ...
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Journal ArticleEur J Echocardiogr · February 2011
UNLABELLED: Aim The presence of septal hypertrophy in hypertrophic cardiomyopathy (HCM) is common. To date, there has been no accepted classification of septal morphology in HCM. Furthermore, the possible relationship between septal morphology and clinical ...
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Journal ArticleJACC Cardiovasc Imaging · July 2010
OBJECTIVES: The aim of this study was to evaluate the impact of renal function by estimated glomerular filtration rate (eGFR) on risk stratification of diabetic and nondiabetic patients undergoing myocardial perfusion imaging (MPI) by single-photon emissio ...
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Journal ArticleJ Electrocardiol · 2010
BACKGROUND: This study was performed to test the hypothesis that there exists a correlation between the Butler-Leggett (BL) criterion for right ventricular hypertrophy on the electrocardiogram and the Qp/Qs shunt ratio in adults with ostium secundum atrial ...
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Journal ArticleJ Invasive Cardiol · November 2009
BACKGROUND: To assess the optimal percutaneous coronary intervention (PCI) approach for coronary artery bifurcation lesions (CBL), we conducted a meta-analysis of randomized trials comparing provisional stenting (PS) to complex stenting strategy (CS). DATA ...
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Journal ArticleAm Heart J · November 2009
BACKGROUND: Although adequate representation of specific subgroups (eg, women and the elderly) in randomized controlled trials (RCTs) has been under intense scrutiny, there are few data on representation by race. METHODS: Using all RCTs cited by the 2007 A ...
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Journal ArticleJ Nucl Cardiol · 2009
BACKGROUND: CRT has been shown to be beneficial in the majority of patients with NYHA class III-IV symptoms, prolonged QRS duration, and an EF < or =35%. The use of imaging modalities to quantify dyssynchrony may help identify patients who may benefit from ...
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Journal ArticleCirculation · December 9, 2008
BACKGROUND: Patients with chronic kidney disease (CKD) have worse cardiovascular outcomes than those without CKD. The prognostic utility of myocardial perfusion single-photon emission CT (MPS) in patients with varying degrees of renal dysfunction and the i ...
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Journal ArticleHeart · May 2008
BACKGROUND: Despite widespread acceptance of echocardiography for diagnosis of infective endocarditis, few investigators have evaluated its utility as a risk-stratification tool to aid therapeutic decision-making. METHODS: A decision tree and Markov analys ...
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Journal ArticleCardiol Rev · 2008
Hypertension is a common and readily modifiable risk factor for cardiovascular and cerebrovascular disease. Despite extensive clinical trial results and efforts to increase public awareness, it remains inadequately controlled in the general population. Wom ...
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Journal ArticleJ Pak Med Assoc · January 2002
OBJECTIVE: Acute Myocardial Infarction (AMI) is a rising epidemic in developing countries. While studies in the West have established the characteristics and management of AMI patients, comprehensive data reflecting these issues in the Pakistani subjects i ...
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Journal ArticleJ Pak Med Assoc · December 2001
OBJECTIVE: To assess the views and prescribing practices of doctors regarding hormone replacement therapy (HRT). METHODS: In April 1999, 103 doctors from a teaching hospital participated in a survey. Using a self-administered questionnaire, subjects were c ...
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