Scholars@Duke publication: A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.

A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.

Publication , Journal Article

McClain, MT; Nicholson, BP; Park, LP; Liu, T-Y; Hero, AO; Tsalik, EL; Zaas, AK; Veldman, T; Hudson, LL; Lambkin-Williams, R; Gilbert, A ...

Published in: Open Forum Infect Dis

January 2016

Published version (DOI) Open Access Copy (Duke) Link to item

Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores of 23.5 vs 46.3), more rapid resolution of clinical disease (20 hours earlier), reduced viral shedding (total median tissue culture infectious dose [TCID50] 7.4 vs 9.7), and significantly reduced expression of several inflammatory cytokines (interferon-γ, tumor necrosis factor-α, interleukin-6, and others). The host genomic response to influenza infection is robust and may provide the means for early detection, more timely therapeutic interventions, a meaningful reduction in clinical disease, and an effective molecular means to track response to therapy.

Duke Scholars

Author Micah Thomas McClain Medicine, Infectious Diseases

Author Ephraim Tsalik Medicine, Infectious Diseases

Author Aimee Kirsch Zaas Medicine, Infectious Diseases

Author Thomas Burke

Author Geoffrey Steven Ginsburg Medicine, Cardiology

Author Christopher Wildrick Woods Medicine, Infectious Diseases

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Published In

Open Forum Infect Dis

DOI

10.1093/ofid/ofw007

ISSN

2328-8957

Publication Date

January 2016

Volume

Issue

Start / End Page

ofw007

Location

United States

Related Subject Headings

3207 Medical microbiology
3202 Clinical sciences

Citation

APA

Chicago

ICMJE

MLA

NLM

McClain, M. T., Nicholson, B. P., Park, L. P., Liu, T.-Y., Hero, A. O., Tsalik, E. L., … Woods, C. W. (2016). A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses. Open Forum Infect Dis, 3(1), ofw007. https://doi.org/10.1093/ofid/ofw007

McClain, Micah T., Bradly P. Nicholson, Lawrence P. Park, Tzu-Yu Liu, Alfred O. Hero, Ephraim L. Tsalik, Aimee K. Zaas, et al. “A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.” Open Forum Infect Dis 3, no. 1 (January 2016): ofw007. https://doi.org/10.1093/ofid/ofw007.

McClain MT, Nicholson BP, Park LP, Liu T-Y, Hero AO, Tsalik EL, et al. A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses. Open Forum Infect Dis. 2016 Jan;3(1):ofw007.

McClain, Micah T., et al. “A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.” Open Forum Infect Dis, vol. 3, no. 1, Jan. 2016, p. ofw007. Pubmed, doi:10.1093/ofid/ofw007.

McClain MT, Nicholson BP, Park LP, Liu T-Y, Hero AO, Tsalik EL, Zaas AK, Veldman T, Hudson LL, Lambkin-Williams R, Gilbert A, Burke T, Nichols M, Ginsburg GS, Woods CW. A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses. Open Forum Infect Dis. 2016 Jan;3(1):ofw007.

Published In

Open Forum Infect Dis

DOI

10.1093/ofid/ofw007

ISSN

2328-8957

Publication Date

January 2016

Volume

Issue

Start / End Page

ofw007

Location

United States

Related Subject Headings

3207 Medical microbiology
3202 Clinical sciences