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The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights.

Publication ,  Journal Article
McCann, JR; Bihlmeyer, NA; Roche, K; Catherine, C; Jawahar, J; Kwee, LC; Younge, NE; Silverman, J; Ilkayeva, O; Sarria, C; Zizzi, A; Poppe, L ...
Published in: Obesity (Silver Spring)
March 2021

OBJECTIVE: The purpose of this study was to establish a biorepository of clinical, metabolomic, and microbiome samples from adolescents with obesity as they undergo lifestyle modification. METHODS: A total of 223 adolescents aged 10 to 18 years with BMI ≥95th percentile were enrolled, along with 71 healthy weight participants. Clinical data, fasting serum, and fecal samples were collected at repeated intervals over 6 months. Herein, the study design, data collection methods, and interim analysis-including targeted serum metabolite measurements and fecal 16S ribosomal RNA gene amplicon sequencing among adolescents with obesity (n = 27) and healthy weight controls (n = 27)-are presented. RESULTS: Adolescents with obesity have higher serum alanine aminotransferase, C-reactive protein, and glycated hemoglobin, and they have lower high-density lipoprotein cholesterol when compared with healthy weight controls. Metabolomics revealed differences in branched-chain amino acid-related metabolites. Also observed was a differential abundance of specific microbial taxa and lower species diversity among adolescents with obesity when compared with the healthy weight group. CONCLUSIONS: The Pediatric Metabolism and Microbiome Study (POMMS) biorepository is available as a shared resource. Early findings suggest evidence of a metabolic signature of obesity unique to adolescents, along with confirmation of previously reported findings that describe metabolic and microbiome markers of obesity.

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Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

March 2021

Volume

29

Issue

3

Start / End Page

569 / 578

Location

United States

Related Subject Headings

  • RNA, Ribosomal, 16S
  • Preliminary Data
  • Pediatric Obesity
  • Metabolomics
  • Male
  • Humans
  • Gastrointestinal Microbiome
  • Female
  • Feces
  • Fasting
 

Citation

APA
Chicago
ICMJE
MLA
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McCann, J. R., Bihlmeyer, N. A., Roche, K., Catherine, C., Jawahar, J., Kwee, L. C., … Armstrong, S. C. (2021). The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights. Obesity (Silver Spring), 29(3), 569–578. https://doi.org/10.1002/oby.23081
McCann, Jessica R., Nathan A. Bihlmeyer, Kimberly Roche, Cameron Catherine, Jayanth Jawahar, Lydia Coulter Kwee, Noelle E. Younge, et al. “The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights.Obesity (Silver Spring) 29, no. 3 (March 2021): 569–78. https://doi.org/10.1002/oby.23081.
McCann JR, Bihlmeyer NA, Roche K, Catherine C, Jawahar J, Kwee LC, et al. The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights. Obesity (Silver Spring). 2021 Mar;29(3):569–78.
McCann, Jessica R., et al. “The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights.Obesity (Silver Spring), vol. 29, no. 3, Mar. 2021, pp. 569–78. Pubmed, doi:10.1002/oby.23081.
McCann JR, Bihlmeyer NA, Roche K, Catherine C, Jawahar J, Kwee LC, Younge NE, Silverman J, Ilkayeva O, Sarria C, Zizzi A, Wootton J, Poppe L, Anderson P, Arlotto M, Wei Z, Granek JA, Valdivia RH, David LA, Dressman HK, Newgard CB, Shah SH, Seed PC, Rawls JF, Armstrong SC. The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights. Obesity (Silver Spring). 2021 Mar;29(3):569–578.
Journal cover image

Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

March 2021

Volume

29

Issue

3

Start / End Page

569 / 578

Location

United States

Related Subject Headings

  • RNA, Ribosomal, 16S
  • Preliminary Data
  • Pediatric Obesity
  • Metabolomics
  • Male
  • Humans
  • Gastrointestinal Microbiome
  • Female
  • Feces
  • Fasting