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Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies.

Publication ,  Journal Article
Hora, B; Li, H; Shen, X; Martin, M; Chen, Y; Berry, M; Evangelous, T; Macintyre, AN; Arus-Altuz, A; Wang, S; Singh, A; Zhao, C; De Naeyer, N ...
Published in: Cell Rep
March 28, 2023

Infants and children infected with human immunodeficiency virus (HIV)-1 have been shown to develop neutralizing antibodies (nAbs) against heterologous HIV-1 strains, characteristic of broadly nAbs (bnAbs). Thus, having a neonatal model for the induction of heterologous HIV-1 nAbs may provide insights into the mechanisms of neonatal bnAb development. Here, we describe a neonatal model for heterologous HIV-1 nAb induction in pathogenic simian-HIV (SHIV)-infected rhesus macaques (RMs). Viral envelope (env) evolution showed mutations at multiple sites, including nAb epitopes. All 13 RMs generated plasma autologous HIV-1 nAbs. However, 8/13 (62%) RMs generated heterologous HIV-1 nAbs with increasing potency over time, albeit with limited breadth, and mapped to multiple nAb epitopes, suggestive of a polyclonal response. Moreover, plasma heterologous HIV-1 nAb development was associated with antigen-specific, lymph-node-derived germinal center activity. We define a neonatal model for heterologous HIV-1 nAb induction that may inform future pediatric HIV-1 vaccines for bnAb induction in infants and children.

Duke Scholars

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Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

March 28, 2023

Volume

42

Issue

3

Start / End Page

112255

Location

United States

Related Subject Headings

  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Macaca mulatta
  • Infant, Newborn
  • Infant
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
 

Citation

APA
Chicago
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MLA
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Hora, B., Li, H., Shen, X., Martin, M., Chen, Y., Berry, M., … Williams, W. B. (2023). Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies. Cell Rep, 42(3), 112255. https://doi.org/10.1016/j.celrep.2023.112255
Hora, Bhavna, Hui Li, Xiaoying Shen, Mitchell Martin, Yue Chen, Madison Berry, Tyler Evangelous, et al. “Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies.Cell Rep 42, no. 3 (March 28, 2023): 112255. https://doi.org/10.1016/j.celrep.2023.112255.
Hora B, Li H, Shen X, Martin M, Chen Y, Berry M, et al. Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies. Cell Rep. 2023 Mar 28;42(3):112255.
Hora, Bhavna, et al. “Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies.Cell Rep, vol. 42, no. 3, Mar. 2023, p. 112255. Pubmed, doi:10.1016/j.celrep.2023.112255.
Hora B, Li H, Shen X, Martin M, Chen Y, Berry M, Evangelous T, Macintyre AN, Arus-Altuz A, Wang S, Singh A, Zhao C, De Naeyer N, DeMarco T, Kuykendall C, Gurley T, Saunders KO, Denny T, Moody MA, Misamore J, Lewis MG, Wiehe K, Cain DW, Montefiori DC, Shaw GM, Williams WB. Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies. Cell Rep. 2023 Mar 28;42(3):112255.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

March 28, 2023

Volume

42

Issue

3

Start / End Page

112255

Location

United States

Related Subject Headings

  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Macaca mulatta
  • Infant, Newborn
  • Infant
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies