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Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated.

Publication ,  Journal Article
Liao, H-X; Chen, X; Munshaw, S; Zhang, R; Marshall, DJ; Vandergrift, N; Whitesides, JF; Lu, X; Yu, J-S; Hwang, K-K; Gao, F; Markowitz, M ...
Published in: J Exp Med
October 24, 2011

The initial antibody response to HIV-1 is targeted to envelope (Env) gp41, and is nonneutralizing and ineffective in controlling viremia. To understand the origins and characteristics of gp41-binding antibodies produced shortly after HIV-1 transmission, we isolated and studied gp41-reactive plasma cells from subjects acutely infected with HIV-1. The frequencies of somatic mutations were relatively high in these gp41-reactive antibodies. Reverted unmutated ancestors of gp41-reactive antibodies derived from subjects acutely infected with HIV-1 frequently did not react with autologous HIV-1 Env; however, these antibodies were polyreactive and frequently bound to host or bacterial antigens. In one large clonal lineage of gp41-reactive antibodies, reactivity to HIV-1 Env was acquired only after somatic mutations. Polyreactive gp41-binding antibodies were also isolated from uninfected individuals. These data suggest that the majority of gp41-binding antibodies produced after acute HIV-1 infection are cross-reactive responses generated by stimulating memory B cells that have previously been activated by non-HIV-1 antigens.

Duke Scholars

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Published In

J Exp Med

DOI

EISSN

1540-9538

Publication Date

October 24, 2011

Volume

208

Issue

11

Start / End Page

2237 / 2249

Location

United States

Related Subject Headings

  • Viremia
  • Viral Load
  • Sequence Analysis, DNA
  • Plasma Cells
  • Phylogeny
  • Mutation
  • Male
  • Immunology
  • Humans
  • HIV-1
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liao, H.-X., Chen, X., Munshaw, S., Zhang, R., Marshall, D. J., Vandergrift, N., … Haynes, B. F. (2011). Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. J Exp Med, 208(11), 2237–2249. https://doi.org/10.1084/jem.20110363
Liao, Hua-Xin, Xi Chen, Supriya Munshaw, Ruijun Zhang, Dawn J. Marshall, Nathan Vandergrift, John F. Whitesides, et al. “Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated.J Exp Med 208, no. 11 (October 24, 2011): 2237–49. https://doi.org/10.1084/jem.20110363.
Liao H-X, Chen X, Munshaw S, Zhang R, Marshall DJ, Vandergrift N, et al. Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. J Exp Med. 2011 Oct 24;208(11):2237–49.
Liao, Hua-Xin, et al. “Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated.J Exp Med, vol. 208, no. 11, Oct. 2011, pp. 2237–49. Pubmed, doi:10.1084/jem.20110363.
Liao H-X, Chen X, Munshaw S, Zhang R, Marshall DJ, Vandergrift N, Whitesides JF, Lu X, Yu J-S, Hwang K-K, Gao F, Markowitz M, Heath SL, Bar KJ, Goepfert PA, Montefiori DC, Shaw GC, Alam SM, Margolis DM, Denny TN, Boyd SD, Marshal E, Egholm M, Simen BB, Hanczaruk B, Fire AZ, Voss G, Kelsoe G, Tomaras GD, Moody MA, Kepler TB, Haynes BF. Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. J Exp Med. 2011 Oct 24;208(11):2237–2249.

Published In

J Exp Med

DOI

EISSN

1540-9538

Publication Date

October 24, 2011

Volume

208

Issue

11

Start / End Page

2237 / 2249

Location

United States

Related Subject Headings

  • Viremia
  • Viral Load
  • Sequence Analysis, DNA
  • Plasma Cells
  • Phylogeny
  • Mutation
  • Male
  • Immunology
  • Humans
  • HIV-1