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Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated.

Publication ,  Journal Article
Liao, H-X; Chen, X; Munshaw, S; Zhang, R; Marshall, DJ; Vandergrift, N; Whitesides, JF; Lu, X; Yu, J-S; Hwang, K-K; Gao, F; Markowitz, M ...
Published in: J Exp Med
October 24, 2011

The initial antibody response to HIV-1 is targeted to envelope (Env) gp41, and is nonneutralizing and ineffective in controlling viremia. To understand the origins and characteristics of gp41-binding antibodies produced shortly after HIV-1 transmission, we isolated and studied gp41-reactive plasma cells from subjects acutely infected with HIV-1. The frequencies of somatic mutations were relatively high in these gp41-reactive antibodies. Reverted unmutated ancestors of gp41-reactive antibodies derived from subjects acutely infected with HIV-1 frequently did not react with autologous HIV-1 Env; however, these antibodies were polyreactive and frequently bound to host or bacterial antigens. In one large clonal lineage of gp41-reactive antibodies, reactivity to HIV-1 Env was acquired only after somatic mutations. Polyreactive gp41-binding antibodies were also isolated from uninfected individuals. These data suggest that the majority of gp41-binding antibodies produced after acute HIV-1 infection are cross-reactive responses generated by stimulating memory B cells that have previously been activated by non-HIV-1 antigens.

Duke Scholars

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Published In

J Exp Med

DOI

EISSN

1540-9538

Publication Date

October 24, 2011

Volume

208

Issue

11

Start / End Page

2237 / 2249

Location

United States

Related Subject Headings

  • Viremia
  • Viral Load
  • Sequence Analysis, DNA
  • Plasma Cells
  • Phylogeny
  • Mutation
  • Male
  • Immunology
  • Humans
  • HIV-1
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liao, H.-X., Chen, X., Munshaw, S., Zhang, R., Marshall, D. J., Vandergrift, N., … Haynes, B. F. (2011). Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. J Exp Med, 208(11), 2237–2249. https://doi.org/10.1084/jem.20110363

Published In

J Exp Med

DOI

EISSN

1540-9538

Publication Date

October 24, 2011

Volume

208

Issue

11

Start / End Page

2237 / 2249

Location

United States

Related Subject Headings

  • Viremia
  • Viral Load
  • Sequence Analysis, DNA
  • Plasma Cells
  • Phylogeny
  • Mutation
  • Male
  • Immunology
  • Humans
  • HIV-1