Beth H. Shaz

Journal Article Expert Rev Hematol · December 30, 2025 INTRODUCTION: Fragmentation across operations, data systems, governance, and regulation leaves many blood supply networks ill-equipped to provide timely, equitable, and crisis-resilient transfusion support. Public health emergencies, such as COVID-19 and n ... Full text Link to item Cite

The promise of TIL therapy for glioblastoma.

Journal Article Trends Cancer · November 13, 2025 Tumor-infiltrating lymphocyte (TIL) therapy has demonstrated efficacy in refractory melanoma and durable responses in lung cancer. Glioblastoma presents distinct challenges for immunotherapy, including profound tumor heterogeneity, low T cell infiltration, ... Full text Link to item Cite

KS03.4.A SPATIAL MULTI-OMIC PROFILING REVEALS DETERMINANTS OF TIL EXPANDABILITY IN HIGH-GRADE GLIOMAS

Conference Neuro-Oncology · October 3, 2025 AbstractBACKGROUNDTumor-infiltrating lymphocyte (TIL) therapy has demonstrated efficacy in melanoma and is emerging as a promising mod ... Full text Cite

Improving lung cancer tumor-infiltrating lymphocyte (TIL) manufacturing.

Journal Article Cytotherapy · October 2025 BACKGROUND: The successful treatment of melanoma using autologous in vitro expanded tumor infiltrating lymphocytes (TILs) has sparked clinical trials for the assessment of TIL efficacy against other cancers, including non-small cell lung cancer (NSCLC). Th ... Full text Link to item Cite

IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models.

Journal Article J Clin Invest · June 16, 2025 The efficacy of T cell-activating therapies against glioma is limited by an immunosuppressive tumor microenvironment and tumor-induced T cell sequestration. We investigated whether peripherally infused nonantigen specific autologous lymphocytes could accum ... Full text Link to item Cite

Surveying local CAR T-cell manufacturing processes to facilitate standardization and expand accessibility.

Journal Article J Transl Med · May 6, 2025 BACKGROUND: Chimeric antigen receptor T-cell (CAR T-cell) therapies have shown significant promise in treating cancers and other diseases. However, the manufacturing processes for CAR T-cell therapies exhibit considerable variability, which can affect trea ... Full text Link to item Cite

A Spatial Multi-Omic Framework Identifies Gliomas Permissive to TIL Expansion.

Journal Article Res Sq · April 25, 2025 Tumor-infiltrating lymphocyte (TIL) therapy, recently approved by the FDA for melanoma, is an emerging modality for cell-based immunotherapy. However, its application in immunologically "cold" tumors such as glioblastoma remains limited due to sparse T cel ... Full text Link to item Cite

IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models.

Preprint · April 14, 2025 Full text Link to item Cite

A Spatial Multi-Omic Framework Identifies Gliomas Permissive to TIL Expansion.

Journal Article bioRxiv · April 12, 2025 Tumor-infiltrating lymphocyte (TIL) therapy, recently approved by the FDA for melanoma, is an emerging modality for cell-based immunotherapy. However, its application in immunologically 'cold' tumors such as glioblastoma remains limited due to sparse T cel ... Full text Link to item Cite

SURVEYING LOCAL CAR-T MANUFACTURING PROCESSES TO PROMOTE STANDARDIZATION OF PROTOCOLS

Conference CYTOTHERAPY · 2025 Cite

Human Umbilical Cord Blood-Derived Cell Therapy in Adults with Primary Progressive Multiple Sclerosis

Conference TRANSFUSION · 2025 Cite

Umbilical Cord Blood Derived Macrophages (DUOC-01) Suppress Neuroinflammation by Limiting the Activation of CNS Barrier Endothelial Cells

Conference TRANSFUSION · 2025 Cite

Autologous Stem Cell Transplantation and Daratumumab: A Case Series on Unexpected Serological Results

Conference TRANSFUSION · 2025 Cite

Transfusions in Lung Transplantation: Reply.

Journal Article Anesthesiology · December 1, 2024 Full text Link to item Cite

IMMU-18. IL-7 MEDIATED UPREGULATION OF VLA-4 INCREASES ACCUMULATION OF ADOPTIVELY TRANSFERRED T LYMPHOCYTES IN MURINE GLIOMA

Conference Neuro-Oncology · November 11, 2024 AbstractWe have previously described the development of a novel brain bi-specific T cell engager (BRiTE) targeting EGFRvIII in Glioma. Despite BRiTEs impressive potency, efficacy in solid tumors is dependent ... Full text Cite

Surveying Local CAR-T Manufacturing Processes to Promote Standardization of Protocols

Conference Blood · November 5, 2024 Background: The availability of CAR-T (Chimeric Antigen Receptor T-cell) therapies is a pivotal advancement in cancer treatment. Local, or point-of-care, manufacturing addresses logistica ... Full text Cite

Differences in microenvironment of lung cancer and pleural effusions by single-cell RNA sequencing.

Journal Article Lung Cancer · July 2024 BACKGROUND: Direct comparison of tumor microenvironment of matched lung cancer biopsies and pleural effusions (PE) from the same patients is critical in understanding tumor biology but has not been performed. This is the first study to compare the lung can ... Full text Link to item Cite

Local manufacturing processes contribute to variability in human mesenchymal stromal cell expansion while growth media supplements contribute to variability in gene expression and cell function: a Biomedical Excellence for Safer Transfusion (BEST) collaborative study.

Conference Cytotherapy · June 2024 BACKGROUND AIMS: Culture-derived mesenchymal stromal cells (MSCs) exhibit variable characteristics when manufactured using different methods, source material and culture media. The purpose of this multicenter study was to assess the impact on MSC expansion ... Full text Link to item Cite

Impact of FDA's HCT/P ZIKV Recommendations on Cord Blood Unit Eligibility and Utilization in a Large Public Cord Blood Bank.

Journal Article Stem Cells Transl Med · May 14, 2024 BACKGROUND: Cord blood units (CBUs) that are ineligible for licensure due to incomplete compliance with FDA recommendations may be used for hematopoietic stem cell transplantation under urgent medical need and an Investigational Drug Application. The large ... Full text Link to item Cite

29 Safety and feasibility of the use of dual cardiac-thymus transplant in a child with cardiac failure requiring heart transplant

Conference Clinical Immunology · May 2024 Full text Cite

Examining Bleeding Risk, Transfusion-related Complications, and Strategies to Reduce Transfusions in Lung Transplantation.

Journal Article Anesthesiology · April 1, 2024 Full text Link to item Cite

Contemporary management of major haemorrhage in critical care.

Journal Article Intensive Care Med · March 2024 Haemorrhagic shock is frequent in critical care settings and responsible for a high mortality rate due to multiple organ dysfunction and coagulopathy. The management of critically ill patients with bleeding and shock is complex, and treatment of these pati ... Full text Link to item Cite

Correction: Contemporary management of major haemorrhage in critical care.

Journal Article Intensive Care Med · March 2024 Full text Link to item Cite

Transfusion Medicine and Hemostasis

Book · January 1, 2024 Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects, Fourth Edition continues to be the only "pocket-size" quick reference for pathology and transfusion medicine for residents and fellows. It is helpful to all physicians and allied health ... Full text Cite

Preface

Journal Article Transfusion Medicine and Hemostasis Clinical and Laboratory Aspects · January 1, 2024 Full text Cite

Albumin and Related Products

Chapter · January 1, 2024 Albumin as compared with nonprotein colloid or crystalloid solutions has not been well addressed in appropriately designed studies. Thus, albumin administration is based on an individual patient's clinical status. Clinical situations where albumin is commo ... Full text Cite

Cord Blood Banking

Chapter · January 1, 2024 Cord blood (CB) is an alternative source of stem cells for hematopoietic and immunologic reconstitution of patients that do not have matched related donors. The functions of public CB banks include collection (CB harvesting, maternal consent, and evaluatio ... Full text Cite

Introduction to Blood Banking and Transfusion Medicine

Chapter · January 1, 2024 A safe, reliable, adequate, and available blood supply is critical to the function of complex healthcare systems worldwide. Blood transfusion is one of the most common therapeutic medical practices. The field of transfusion medicine (blood banking and tran ... Full text Cite

Blood and Its Components.

Journal Article JAMA · November 21, 2023 Full text Link to item Cite

Cord Blood Connect 2023 Abstracts

Journal Article Stem Cells Translational Medicine · September 1, 2023 Full text Cite

Feasibility Study of Cord Tissue Derived Mesenchymal Stromal Cells in COVID-19-Related Acute Respiratory Distress Syndrome.

Journal Article Stem Cells Transl Med · April 17, 2023 BACKGROUND: Treatment options for patients with COVID-19-related acute respiratory distress syndrome (ARDS) are desperately needed. Allogeneic human umbilical cord derived mesenchymal stromal cells (hCT-MSCs) have potential therapeutic benefits in these cr ... Full text Link to item Cite

Abstract 3193: Developing non-exhausted tumor infiltrating lymphocytes (TILs) as a therapy for glioblastoma

Conference Cancer Research · April 4, 2023 AbstractGlioblastoma is the most prevalent primary brain malignancy, with a median survival of less than 21 months despite treatment with surgery, radiation, and chemotherapy. Significant intra-tumoral heter ... Full text Cite

The potential cost-effectiveness of novel cord blood therapies in children with autism spectrum disorder.

Journal Article PLoS One · 2023 OBJECTIVE: To model the long-term clinical and economic outcomes of potential cord blood therapy in autism spectrum disorder (ASD). STUDY DESIGN: Markov microsimulation of ASD over the lifespan was used to compare two strategies: 1) standard of care (SOC), ... Full text Link to item Cite

NEW APPROACHES FOR EXPANDING GLIOBLASTOMA INFILTRATING LYMPHOCYTES

Conference CYTOTHERAPY · 2023 Cite

DEVELOPING A POTENCY ASSAY FOR CORD TISSUE MESENCHYMAL STROMAL CELLS

Conference CYTOTHERAPY · 2023 Cite

MANUFACTURE IMPROVEMENTS FOR TUMOR-INFILTRATING LYMPHOCYTES FROM HUMAN NON-SMALL CELL LUNG CANCER

Conference CYTOTHERAPY · 2023 Cite

DEVELOPING PATIENT SPECIFIC TUMOR INFILTRATING LYMPHOCYTES (TILS) WITH INCREASED TUMOR SPECIFICITY AS A THERAPY FOR GLIOBLASTOMA

Conference NEURO-ONCOLOGY · 2023 Cite

NEW APPROACHES FOR EXPANDING GLIOBLASTOMA INFILTRATING LYMPHOCYTES

Conference NEURO-ONCOLOGY · 2023 Cite

Transfusion Medicine

Chapter · January 1, 2023 Blood transfusion can be lifesaving and is currently the safest it has ever been. However, blood transfusion is associated with multiple adverse outcomes, including both noninfectious and infectious complications. Some mitigation strategies include donor t ... Full text Cite

A randomized trial of blood donor iron repletion on red cell quality for transfusion and donor cognition and well-being.

Journal Article Blood · December 22, 2022 Although altruistic regular blood donors are vital for the blood supply, many become iron deficient from donation-induced iron loss. The effects of blood donation-induced iron deficiency on red cell transfusion quality or donor cognition are unknown. In th ... Full text Link to item Cite

Expanding the platelet inventory to mitigate the impact of severe shortages.

Journal Article Hematology Am Soc Hematol Educ Program · December 9, 2022 The platelet collection and distribution system, based on volunteer nonremunerated donors, apheresis platelet collections, and primarily 1-directional distribution of platelets for up to 5-day room temperature storage at hospitals, typically performs well ... Full text Link to item Cite

Blood donation motivators and barriers reported by young, first-time whole blood donors: Examining the association of reported motivators and barriers with subsequent donation behavior and potential sex, race, and ethnic group differences.

Journal Article Transfusion · December 2022 BACKGROUND: A greater understanding of young, first-time donor motivators and barriers is needed to address the ongoing challenge of retaining these essential donors. STUDY DESIGN AND METHODS: Structured interviews conducted with 508 young, first-time whol ... Full text Link to item Cite

Abstract 12 Phase I Study of Cord Tissue Derived Mesenchymal Stromal Cells in COVID-19–Related Acute Respiratory Distress Syndrome

Conference Stem Cells Translational Medicine · September 6, 2022 AbstractIntroductionSARS-CoV-2 infection results in the COVID-19 disease that caused a global pandemic. In severe cases, COVID-19 lead ... Full text Cite

Abstract 24 Improving Cord Blood Unit Selection and Optimizing Manufacturing of a Unique Cord Blood-Derived Product (DUOC-01)

Conference Stem Cells Translational Medicine · September 6, 2022 AbstractIntroductionDUOC-01 are microglia-like cells derived from umbilical cord blood CD14-positive monocytes, which have been shown ... Full text Cite

Abstract 27 Limitations of Current Human Cell, Tissue, and Cellular-based Product Donor Eligibility Guidance: Analyzing the Impact on a Large Public Cord Blood Bank

Conference Stem Cells Translational Medicine · September 6, 2022 AbstractIntroductionCord blood (CB) is considered a human cell, tissue, and cellular-based product (HCT/P) by the U.S. Food and Drug A ... Full text Cite

Abstract 18 Developing a Potency Assay for Cord Tissue MSCs

Conference Stem Cells Translational Medicine · September 6, 2022 AbstractIntroductionThe potency of mesenchymal stromal cells (MSCs) can be assessed by their ability to suppress proliferation of thir ... Full text Cite

Clinical Practice Guidelines From the Association for the Advancement of Blood and Biotherapies (AABB): COVID-19 Convalescent Plasma.

Journal Article Ann Intern Med · September 2022 DESCRIPTION: Coronavirus disease 2019 convalescent plasma (CCP) has emerged as a potential treatment of COVID-19. However, meta-analysis data and recommendations are limited. The Association for the Advancement of Blood and Biotherapies (AABB) developed cl ... Full text Link to item Cite

Evaluation of amotosalen and UVA pathogen-reduced apheresis platelets after 7-day storage.

Journal Article Transfusion · August 2022 BACKGROUND: Amotosalen/UVA pathogen-reduced platelet components (PRPCs) with storage up to 7 days are standard of care in France, Switzerland, and Austria. PRPCs provide effective hemostasis with reduced risk of transfusion-transmitted infections and trans ... Full text Link to item Cite

COVID-19 convalescent plasma.

Journal Article Blood · July 21, 2022 As the coronavirus disease (COVID-19) pandemic led to a global health crisis, there were limited treatment options and no prophylactic therapies for those exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma is quick ... Full text Link to item Cite

Blood donor eligibility criteria for medical conditions: A BEST collaborative study.

Journal Article Vox Sang · July 2022 BACKGROUND AND OBJECTIVES: Donor eligibility questions and criteria for medical conditions vary between blood centres, suggesting that they are based more on local regulations or experience, rather than on published data, which are limited. As the donor po ... Full text Link to item Cite

SAFETY OF CORD TISSUE DERIVED MESENCHYMAL STROMAL CELLS IN COVID-19 RELATED ACUTE RESPIRATORY DISTRESS SYNDROME

Conference CYTOTHERAPY · 2022 Cite

RAPID EXPANSION PROTOCOL OPTIMIZATION FOR TUMOR INFILTRATING LYMPHOCYTES

Conference CYTOTHERAPY · 2022 Cite

Effects of Blood Donor Iron Deficiency on Red Cell Quality for Transfusion and on Donor Quality of Life and Cognition: The DIDS Randomized Clinical Trial

Conference TRANSFUSION · 2022 Cite

Transfusion-Associated Graft-versus- Host Disease and Microchimerism

Chapter · January 1, 2022 Transfusion-associated graft-versus-host disease (TA-GVHD) is an uncommon yet almost always fatal complication of cellular blood component transfusion. The diagnosis of TA-GVHD is based on the characteristic clinical manifestations, pathological findings o ... Full text Cite

Principles Of Plasma And Plasma Derivatives

Chapter · January 1, 2022 Plasma and its derivatives are well-established clinical resources, but cost, risk of infectious disease transmission, although rare, and other adverse effects mandate their appropriate use. Continued investigation is warranted to clarify optimal and appro ... Full text Cite

Human Blood Group Antigens and Antibodies

Chapter · January 1, 2022 Pretransfusion testing includes ABO and Rhesus (Rh) type, and antibody screening to determine whether a patient has an unexpected red blood cell (RBC) antibody against a blood group antigen. If the antibody screen is positive, an identification panel is pe ... Full text Cite

Fear is associated with attrition of first-time whole blood donors: A longitudinal examination of donor confidence and attitude as potential mediators.

Journal Article Transfusion · December 2021 BACKGROUND: Elevated fear and anxiety regarding donation-related stimuli (e.g., needles, pain, blood, fainting) has been associated with reduced blood donor recruitment and retention. The present longitudinal study tests the notion that this inverse relati ... Full text Link to item Cite

Promoting awareness of donation-related iron depletion among high risk blood donors.

Journal Article Transfusion · December 2021 BACKGROUND: The potential for iron deficiency is a known blood donor health concern and suggests the need to inform donors about the potential risks of low iron levels as well as strategies to address these risks. STUDY DESIGN AND METHODS: Frequent (n = 90 ... Full text Link to item Cite

Access to and safety of COVID-19 convalescent plasma in the United States Expanded Access Program: A national registry study.

Journal Article PLoS Med · December 2021 BACKGROUND: The United States (US) Expanded Access Program (EAP) to coronavirus disease 2019 (COVID-19) convalescent plasma was initiated in response to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent o ... Full text Link to item Cite

Results from the blood donor competence, autonomy, and relatedness enhancement (blood donor CARE) randomized trial.

Journal Article Transfusion · September 2021 BACKGROUND: This study aimed to promote competence, autonomy, and relatedness among first-time whole blood donors to enhance intrinsic motivation and increase retention. STUDY DESIGN AND METHODS: Using a full factorial design, first-time donors (N = 2002) ... Full text Link to item Cite

Blood transfusions in gunshot-wound-related emergency department visits and hospitalizations in the United States.

Journal Article Transfusion · August 2021 BACKGROUND: The United States (US) leads all high-income countries in gunshot wound (GSW) deaths. However, previous US studies have not evaluated the national blood transfusion utilization patterns in hospitalized GSW patients. METHODS: Data from 2016 to 2 ... Full text Link to item Cite

Screening of blood donors for sickle cell trait using a DNA-based approach: Frequency in a multiethnic donor population.

Journal Article Transfusion · July 2021 BACKGROUND: Minority RBC donors are important to support the transfusion needs of patients with sickle cell disease. Testing of donors for sickle cell trait (SCT) is performed to avoid transfusion of hemoglobin S+ (HbS+) RBCs to specific patient groups and ... Full text Link to item Cite

A randomized double-blind controlled trial of convalescent plasma in adults with severe COVID-19.

Journal Article J Clin Invest · July 1, 2021 BACKGROUNDAlthough convalescent plasma has been widely used to treat severe coronavirus disease 2019 (COVID-19), data from randomized controlled trials that support its efficacy are limited.METHODSWe conducted a randomized, double-blind, controlled trial a ... Full text Link to item Cite

Frequency of rare, serious donor reactions: International perspective.

Journal Article Transfusion · June 2021 BACKGROUND: Severe blood donor adverse events are rare, but due to their rarity studying them can be difficult. To get an accurate estimate of their frequency and rate in the donor population it may be necessary to combine donation data across countries. S ... Full text Link to item Cite

COVID-19 convalescent plasma: Interim recommendations from the AABB.

Journal Article Transfusion · April 2021 Full text Link to item Cite

Commentary: Patient blood management in the era of coronavirus disease 2019-is anything really different?

Journal Article JTCVS Open · March 2021 Full text Link to item Cite

Transfusion reactions associated with COVID-19 convalescent plasma therapy for SARS-CoV-2.

Journal Article Transfusion · January 2021 BACKGROUND: Convalescent plasma (CP) for treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown preliminary signs of effectiveness in moderate to severely ill patients in reducing mortality. While studies have demonstrated a lo ... Full text Link to item Cite

Examination of the relationship between iron status and cognitive function among healthy young women with and without a recent history of blood donation.

Journal Article Transfusion · December 2020 BACKGROUND: With growing awareness of the prevalence of nonanemic iron deficiency among blood donors, there is a need to explore the extent of potential negative consequences. This study examined the relationship between various measures of iron status, bl ... Full text Link to item Cite

Warming Up to Cold-stored Platelets.

Journal Article Anesthesiology · December 1, 2020 Full text Link to item Cite

Catch those antibodies before they fall.

Journal Article Blood · November 26, 2020 In this issue of Blood, Perreault et al showed decreasing total antibody levels over time in 15 repeat COVID-19 convalescent plasma (CCP) donors with at least 4 donations. The decrease was greatest between the final 2 time points reported, from days 70 to ... Full text Link to item Cite

Correction to: Evaluating the efficacy and safety of human anti-SARS-CoV-2 convalescent plasma in severely ill adults with COVID-19: A structured summary of a study protocol for a randomized controlled trial.

Journal Article Trials · November 17, 2020 An amendment to this paper has been published and can be accessed via the original article. ... Full text Link to item Cite

Trends in platelet distributions from 2008 to 2017: a survey of twelve national and regional blood collectors.

Journal Article Vox Sang · November 2020 BACKGROUND: This multi-national study evaluated changes in platelet (PLT) unit distributions at 12 national or regional blood collectors over a 10-year period. METHODS: Data on the total number of PLT distributions, the collection method, that is apheresis ... Full text Link to item Cite

Comparative changes of pre-operative autologous transfusions and peri-operative cell salvage in the United States.

Journal Article Transfusion · October 2020 BACKGROUND: With improved safety of allogeneic blood supply, the use of preoperative autologous donations (PADs) and perioperative autologous cell salvage (PACS) has evolved. This study evaluated temporal trends in PAD and PACS use in the United States. ME ... Full text Link to item Cite

Use of a rapid electronic survey methodology to estimate blood donors' potential exposure to emerging infectious diseases: Application of a statistically representative sampling methodology to assess risk in US blood centers.

Journal Article Transfusion · September 2020 UNLABELLED: Risk assessments of transfusion-transmitted emerging infectious diseases (EIDs) are complicated by the fact that blood donors' demographics and behaviors can be different from the general population. Therefore, when assessing potential blood do ... Full text Link to item Cite

COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors.

Journal Article BMC Res Notes · August 6, 2020 OBJECTIVE: COVID19 has caused a global and ongoing pandemic. The need for population seroconversion data is apparent to monitor and respond to the pandemic. Using a lateral flow assay (LFA) testing platform, the seropositivity in 63 New York Blood Center ( ... Full text Link to item Cite

Earlier the better: convalescent plasma.

Journal Article Blood · August 6, 2020 In the current issue of Blood, Xia et al evaluate the use of convalescent plasma for the treatment of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19)., SARS-CoV-2 has spurred a gl ... Full text Link to item Cite

How did we rapidly implement a convalescent plasma program?

Journal Article Transfusion · July 2020 Since the beginning of the COVID-19 pandemic, the use of convalescent plasma as a possible treatment has been explored. Here we describe our experience as the first U.S. organization creating a COVID-19 convalescent plasma program to support its use throug ... Full text Link to item Cite

A randomized controlled trial of a tablet-based intervention to address predonation fears among high school donors.

Journal Article Transfusion · July 2020 BACKGROUND: Prior studies have shown donation-related fear to be associated with decreased donor confidence and an increased risk for vasovagal reactions. This study examined the effects of a predonation intervention that provided fearful donors with sugge ... Full text Link to item Cite

Correction to: Evaluating the efficacy and safety of human anti-SARS-CoV-2 convalescent plasma in severely ill adults with COVID-19: A structured summary of a study protocol for a randomized controlled trial.

Journal Article Trials · June 16, 2020 An amendment to this paper has been published and can be accessed via the original article. ... Full text Link to item Cite

Evaluating the efficacy and safety of human anti-SARS-CoV-2 convalescent plasma in severely ill adults with COVID-19: A structured summary of a study protocol for a randomized controlled trial.

Journal Article Trials · June 8, 2020 OBJECTIVES: The aim of this study is to evaluate the efficacy and safety of human anti-SARS-CoV-2 convalescent plasma in hospitalized adults with severe SARS-CoV-2 infection. TRIAL DESIGN: This is a prospective, single-center, phase 2, randomized, controll ... Full text Link to item Cite

Remunerating donors to ensure a safe and available blood supply.

Journal Article Transfusion · June 2020 Full text Link to item Cite

Deployment of convalescent plasma for the prevention and treatment of COVID-19.

Journal Article J Clin Invest · June 1, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), has spurred a global health crisis. To date, there are no proven options for prophylaxis for those who have been exposed to SARS-CoV-2, nor ther ... Full text Link to item Cite

Zika virus and its implications on cord blood banking and transplantation.

Journal Article Transfusion · May 2020 Umbilical cord blood is an important cellular therapy product used for hematopoietic stem cell transplantation, but the US Food and Drug Administration guidance regarding donor screening to reduce the risk of Zika transmission has decreased the number of l ... Full text Link to item Cite

Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion.

Journal Article J Clin Invest · May 1, 2020 BACKGROUNDGlucose-6-phosphate dehydrogenase (G6PD) deficiency decreases the ability of red blood cells (RBCs) to withstand oxidative stress. Refrigerated storage of RBCs induces oxidative stress. We hypothesized that G6PD-deficient donor RBCs would have in ... Full text Link to item Cite

Perioperative Transfusions and Venous Thromboembolism.

Journal Article Pediatrics · April 2020 BACKGROUND AND OBJECTIVES: Annual incidence of venous thromboembolism (VTE) including postoperative VTE in hospitalized children is rising significantly. A growing body of evidence supports the role of red blood cells (RBCs) in pathologic thrombosis. In th ... Full text Link to item Cite

Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings.

Journal Article Anesthesiology · March 2020 BACKGROUND: Group O erythrocytes and/or whole blood are used for urgent transfusions in patients of unknown blood type. This study investigated the impact of transfusing increasing numbers of uncrossmatched type O products on the recipient's first in-hospi ... Full text Link to item Cite

The impact of age and sex on first-time donor return behavior.

Journal Article Transfusion · January 2020 BACKGROUND: This study examined the impact of age and sex of first-time donors who had not experienced an adverse event or deferral on their likelihood of and time to return. STUDY DESIGN AND METHODS: On behalf of the Biomedical Excellence for Safer Transf ... Full text Link to item Cite

Not all red cell concentrate units are equivalent: international survey of processing and in vitro quality data.

Journal Article Vox Sang · November 2019 INTRODUCTION: In vitro qualitative differences exist in red cell concentrates (RCCs) units processed from whole blood (WB) depending on the method of processing. Minimal literature exists on differences in processing and variability in quality data. Theref ... Full text Link to item Cite

Sociodemographic and behavioral characteristics associated with blood donation in the United States: a population-based study.

Journal Article Transfusion · September 2019 BACKGROUND: Contemporary population-based data on characteristics associated with blood donation in the United States (U.S.) are limited. STUDY DESIGN AND METHODS: A cross-sectional analysis was performed among 28,739 persons aged 18 years and older who pa ... Full text Link to item Cite

An automated motivational interview promotes donation intention and self-efficacy among experienced whole blood donors.

Journal Article Transfusion · September 2019 BACKGROUND: Interventions intended to motivate donors to return can be costly and time consuming. The current study examined the effect of a Web-based automated interview, informed by motivational interviewing and self-determination theory, on donor intent ... Full text Link to item Cite

Ten years of TRALI mitigation: measuring our progress.

Journal Article Transfusion · August 2019 BACKGROUND: Transfusion-related acute lung injury (TRALI) is a leading cause of transfusion-associated mortality for which multiple mitigation strategies have been implemented over the past decade. However, product-specific TRALI rates have not been report ... Full text Link to item Cite

Critical developments of 2018: A review of the literature from selected topics in transfusion. A committee report from the AABB's Clinical Transfusion Medicine Committee.

Journal Article Transfusion · August 2019 BACKGROUND: The AABB compiles an annual synopsis of the published literature covering important developments in the field of transfusion medicine. An abridged version of this work is being made available in TRANSFUSION, with the full-length report availabl ... Full text Link to item Cite

Donor Iron Deficiency Study (DIDS): protocol of a study to test whether iron deficiency in blood donors affects red blood cell recovery after transfusion.

Journal Article Blood Transfus · July 2019 BACKGROUND: Despite fulfilling all requirements for blood donation, a large proportion of regular blood donors are iron deficient. Red blood cells (RBC) from iron-deficient donors may be particularly susceptible to damage induced by standard refrigerated s ... Full text Link to item Cite

Reexamination of the chromium-51-labeled posttransfusion red blood cell recovery method.

Journal Article Transfusion · July 2019 BACKGROUND: The chromium-51-labeled posttransfusion recovery (PTR) study has been the gold-standard test for assessing red blood cell (RBC) quality. Despite guiding RBC storage development for decades, it has several potential sources for error. METHODS: F ... Full text Link to item Cite

Red blood cells: beyond the transfusion.

Journal Article Blood · June 20, 2019 Full text Link to item Cite

Association of blood donation with iron deficiency among adolescent and adult females in the United States: a nationally representative study.

Journal Article Transfusion · May 2019 BACKGROUND: Blood donation results in a loss of iron stores, which is particularly concerning for young female blood donors. This study examines the association of blood donation and iron deficiency among adolescent and adult females in the United States. ... Full text Link to item Cite

Noninfectious transfusion-associated adverse events and their mitigation strategies.

Journal Article Blood · April 25, 2019 Blood transfusions are life-saving therapies; however, they can result in adverse events that can be infectious or, more commonly, noninfectious. The most common noninfectious reactions include febrile nonhemolytic transfusion reactions, allergic transfusi ... Full text Link to item Cite

Safety of blood donation by individuals over age 70 and their contribution to the blood supply in five developed countries: a BEST Collaborative group study.

Journal Article Transfusion · April 2019 BACKGROUND: Some countries impose an upper age limit on whole blood and double RBC donation while others do not. We evaluated the safety of blood donation in older individuals (≥71 years), and their contribution to the blood supply of five countries. STUDY ... Full text Link to item Cite

Factors associated with red blood cell, platelet, and plasma transfusions among inpatient hospitalizations: a nationally representative study in the United States.

Journal Article Transfusion · February 2019 BACKGROUND: Demographic and hospital-level factors associated with red blood cell (RBC), plasma, and platelet transfusions in hospitalized patients across the U.S. are not well characterized. METHODS: We conducted a retrospective analysis of the National I ... Full text Link to item Cite

Seasonal variability is not observed in the rates of high anti-A and anti-B titers in plasma, apheresis platelet, and whole blood units tested by different methods.

Journal Article Transfusion · February 2019 BACKGROUND: ABO-incompatible platelet transfusions are common, and transfusions with ABO-incompatible plasma are increasing with the use of group A plasma and group O whole blood (WB) in emergencies. Many centers screen blood products for anti-A and/or ant ... Full text Link to item Cite

Donor incentives improve cardiovascular disease risk profile and donation rates.

Journal Article Transfusion · January 2019 BACKGROUND: Blood centers may offer point-based reward systems or cardiovascular disease (CVD) screening to incentivize donors. However, combining these incentives to improve CVD risk and blood donation rates has not been studied. STUDY DESIGN AND METHODS: ... Full text Link to item Cite

Transfusion-Transmitted Zika Virus Infection in Pregnant Mice Leads to Broad Tissue Tropism With Severe Placental Damage and Fetal Demise.

Journal Article Front Microbiol · 2019 Zika virus (ZIKV) infection during pregnancy can cause significant problems, particularly congenital Zika syndrome. Nevertheless, the potential deleterious consequences and associated mechanisms of transfusion-transmitted ZIKV infection on pregnant individ ... Full text Link to item Cite

Human Immunoglobulin Preparations

Chapter · 2019 Full text Cite

Other Blood Group Systems, Collections, and Series

Chapter · 2019 Full text Cite

MNS and Duffy Blood Group Systems

Chapter · 2019 Full text Cite

Therapeutic Phlebotomy

Chapter · 2019 Full text Cite

Iron Overload

Chapter · 2019 Full text Cite

Age- and sex-dependent changes in levels of circulating brain-enriched microRNAs during normal aging.

Journal Article Aging (Albany NY) · October 31, 2018 Aging is a major risk factor for many common and life-threatening pathologies. The development of reliable biomarkers of aging should lead to a better understanding of aging-associated processes and facilitate the development of therapeutic regimens that d ... Full text Link to item Cite

Association of Perioperative Red Blood Cell Transfusions With Venous Thromboembolism in a North American Registry.

Journal Article JAMA Surg · September 1, 2018 IMPORTANCE: Increasing evidence supports the role of red blood cells (RBCs) in physiological hemostasis and pathologic thrombosis. Red blood cells are commonly transfused in the perioperative period; however, their association with postoperative thrombotic ... Full text Link to item Cite

Risk-based decision making: a good start to aiding US blood policy decisions?

Journal Article Transfusion · August 2018 Full text Link to item Cite

Apheresis to Mitigate Atherosclerotic Vascular Disease.

Conference Am J Hypertens · July 16, 2018 BACKGROUND: Therapeutic apheresis is a term used to describe a group of treatments where blood components are separated in real time, and one component is removed, exchanged, and/or treated to remove pathogenic substances from the circulation. Plasma excha ... Full text Link to item Cite

The Development of a Social Networking-Based Relatedness Intervention Among Young, First-Time Blood Donors: Pilot Study.

Journal Article JMIR Public Health Surveill · April 26, 2018 BACKGROUND: Increasing repeat blood donation behavior is a critical public health goal. According to self-determination theory, the process of developing internal motivation to give blood and an associated self-identity as a blood donor may be promoted by ... Full text Link to item Cite

Critical developments of 2017: a review of the literature from selected topics in transfusion. A committee report from the AABB Clinical Transfusion Medicine Committee.

Journal Article Transfusion · April 2018 BACKGROUND: The AABB compiles an annual synopsis of the published literature covering important developments in the field of Transfusion Medicine. For the first time, an abridged version of this work is being made available in TRANSFUSION, with the full-le ... Full text Link to item Cite

PAS-C platelets contain less plasma protein, lower anti-A and anti-B titers, and decreased HLA antibody specificities compared to plasma platelets.

Journal Article Transfusion · April 2018 BACKGROUND: Platelets (PLTs) collected and stored in PLT additive solution Intersol (PAS-C) are presumed to reduce recipient exposure to donor plasma components; however, the effects of PAS-C on PLT supernatant composition are poorly defined. Therefore, we ... Full text Link to item Cite

Changes in plasma unit distributions to hospitals over a 10-year period.

Journal Article Transfusion · April 2018 BACKGROUND: There are many influences on a hospital's demand for plasma. Pharmaceuticals are now being administered for many indications instead of plasma, although trauma resuscitation now emphasizes increased and early intervention with plasma. This mult ... Full text Link to item Cite

Transfusion-transmitted and community-acquired babesiosis in New York, 2004 to 2015.

Journal Article Transfusion · March 2018 BACKGROUND: Babesiosis is a potentially life-threatening zoonotic infection most frequently caused by the intraerythrocytic parasite Babesia microti. The pathogen is usually tickborne, but may also be transfusion or vertically transmitted. Healthy persons, ... Full text Link to item Cite

Transfusion of Plasma and Plasma Derivatives: Plasma, Cryoprecipitate, Albumin, and Immunoglobulins

Chapter · January 1, 2018 Full text Cite

Human Blood Group Antigens and Antibodies

Chapter · January 1, 2018 Full text Cite

Trends in antigen-negative red blood cell distributions by racial or ethnic groups in the United States.

Journal Article Transfusion · January 2018 BACKGROUND: The overall number of red blood cell (RBC) units distributed to hospitals throughout the world and in the United States has decreased lately. This study was performed to determine if the number of antigen-negative RBC units distributed to hospi ... Full text Link to item Cite

Survey on Transfusion-Transmitted Cytomegalovirus and Cytomegalovirus Disease Mitigation.

Journal Article Arch Pathol Lab Med · December 2017 CONTEXT: - Cytomegalovirus (CMV) can be transmitted by cellular blood products, leading to severe disease in immunosuppressed patients such as neonates and transplant recipients. To mitigate transfusion-transmitted CMV (TT-CMV), "CMV-safe" blood products ( ... Full text Link to item Cite

A motivational interview promotes retention of blood donors with high internal motivation.

Journal Article Transfusion · October 2017 BACKGROUND: Based on the hypothesis that self-determined motivation is associated with an increased likelihood of future behavior, the present study examined the ability of a motivational interview to promote internal motivation for giving blood and future ... Full text Link to item Cite

Infectious complications of blood transfusion

Chapter · September 20, 2017 Consequent to refined donor selection and laboratory screening, blood transfusion in the United States is remarkably safe. Nonetheless, emerging and reemerging pathogens may pose risk to the blood supply, underscoring the need for ongoing vigilance and dev ... Full text Cite

The Development of a Social Networking�Based Relatedness Intervention Among Young, First-Time Blood Donors: Pilot Study (Preprint)

Journal Article · September 15, 2017 BACKGROUNDIncreasing repeat blood donation behavior is a critical public health goal. According to self-determination theory, the process of developing internal motivation to give blood a ... Full text Cite

How do we manage blood donors and recipients after a positive Zika screening result?

Journal Article Transfusion · September 2017 Zika virus (ZIKV) is a mosquito-borne flavivirus that is the focus of an ongoing pandemic. ZIKV is notable for its severe neurologic sequelae in babies born to infected mothers. High rates of subclinical infection, as evidenced by the finding of ZIKV RNA i ... Full text Link to item Cite

Trends in age and red blood cell donation habits among several racial/ethnic minority groups in the United States.

Journal Article Transfusion · July 2017 BACKGROUND: To meet the needs of a diverse patient population, an adequate supply of red blood cells (RBCs) from ethnic/racial minority donors is essential. We previously described the 10-year changes in minority blood donation in the United States. This s ... Full text Link to item Cite

Implications of the US Food and Drug Administration draft guidance for mitigating septic reactions from platelet transfusions.

Journal Article Blood Adv · June 27, 2017 Full text Link to item Cite

Impact of predictive scoring model and e-mail messages on African American blood donors.

Journal Article Transfusion · June 2017 BACKGROUND: Expanding the African American (AA) donor pool is critical to sustain transfusion support for sickle cell disease patients. STUDY DESIGN AND METHODS: The aims were to: 1) apply cognitive computing on donation related metrics to develop a predic ... Full text Link to item Cite

Trends in US minority red blood cell unit donations.

Journal Article Transfusion · May 2017 BACKGROUND: To provide the appropriately diverse blood supply necessary to support alloimmunized and chronically transfused patients, minority donation recruitment programs have been implemented. This study investigated temporal changes in minority red blo ... Full text Link to item Cite

Donating blood on a regular basis appears to reduce blood pressure, but appearances can be deceiving.

Journal Article Transfusion · April 2017 BACKGROUND: Previous studies have reported a relationship between blood donation and decreased risk for cardiovascular events, and it has been proposed that this may be due to a lowering of blood pressure among hypertensive individuals who donate on a regu ... Full text Link to item Cite

First cases of Zika virus-infected US blood donors outside states with areas of active transmission.

Journal Article Transfusion · March 2017 BACKGROUND: Zika virus (ZIKV) is transmitted by Aedes mosquitos and can result in severe congenital and adult neurologic abnormalities. ZIKV has rapidly spread northward through Central America and the Caribbean and autochthonous cases have been identified ... Full text Link to item Cite

Alternatives in blood operations when choosing non-DEHP bags.

Journal Article Vox Sang · February 2017 The use of di-ethylhexyl-phthalate (DEHP) in blood bags is under discussion due to toxicity concerns and possible restrictions. A questionnaire among 15 blood centres in nine countries showed that none so far have fully switched to non-DEHP blood bags. If ... Full text Link to item Cite

Correlation of West Nile Virus Incidence in Donated Blood with West Nile Neuroinvasive Disease Rates, United States, 2010-2012.

Journal Article Emerg Infect Dis · February 2017 Over the past decade, West Nile virus (WNV) has spread across the United States. We aggregated blood donor data from 2010-2012 and then calculated the incidence of WNV RNA-positive donations and compared the incidence with neuroinvasive disease (NID) case ... Full text Link to item Cite

Applying self-determination theory to the blood donation context: The blood donor competence, autonomy, and relatedness enhancement (Blood Donor CARE) trial.

Journal Article Contemp Clin Trials · February 2017 The Blood Donor Competency, Autonomy, and Relatedness Enhancement (Blood Donor CARE) project was designed as a practical application of self-determination theory to encourage retention of first-time donors. Self-determination theory proposes that people ar ... Full text Link to item Cite

Recent viral infection in US blood donors and health-related quality of life (HRQOL).

Journal Article Qual Life Res · February 2017 PURPOSE: Blood donors are considered to be one of the healthiest populations, but relatively little is known about their perceived quality of life. The objective was to examine HRQOL in donors infected with HIV, HBV, HCV or HTLV and a comparison group. MET ... Full text Link to item Cite

Prolonged red cell storage before transfusion increases extravascular hemolysis.

Journal Article J Clin Invest · January 3, 2017 BACKGROUND: Some countries have limited the maximum allowable storage duration for red cells to 5 weeks before transfusion. In the US, red blood cells can be stored for up to 6 weeks, but randomized trials have not assessed the effects of this final week o ... Full text Link to item Cite

Impact of Uniform Methods on Interlaboratory Antibody Titration Variability: Antibody Titration and Uniform Methods.

Conference Arch Pathol Lab Med · January 2017 CONTEXT: -Substantial variability between different antibody titration methods prompted development and introduction of uniform methods in 2008. OBJECTIVE: -To determine whether uniform methods consistently decrease interlaboratory variation in proficiency ... Full text Link to item Cite

Zika Virus and the Blood Supply: What Do We Know?

Journal Article Transfus Med Rev · January 2017 Zika virus (ZIKV), a mosquito-borne Flavivirus and emerging infectious disease, is the focus of an international public health emergency after its rapid spread through the Americas and the Caribbean. Although most ZIKV infections are subclinical or charact ... Full text Link to item Cite

Transfusion of Plasma and Plasma Derivatives

Chapter · January 1, 2017 Full text Cite

Human Blood Group Antigens and Antibodies

Chapter · January 1, 2017 Full text Cite

Storage characteristics of multiple-donor pooled red blood cells compared to single-donor red blood cell units.

Journal Article Transfusion · December 2016 BACKGROUND: Each unit of blood donated is processed and stored individually resulting in variability in the amount of red blood cells (RBCs) collected, RBC properties, and the 24-hour posttransfusion RBC survivability. As a result, each unit differs in its ... Full text Link to item Cite

Evidence of relative iron deficiency in platelet- and plasma-pheresis donors correlates with donation frequency.

Journal Article J Clin Apher · December 2016 BACKGROUND: The loss of iron stores and resulting iron deficiency is well documented in whole blood or red blood cell donors. We hypothesized that relative iron deficiency also occurs as a result of more frequent platelet- and plasma-pheresis (apheresis) d ... Full text Link to item Cite

Development of a multisystem surveillance database for transfusion-transmitted infections among blood donors in the United States.

Journal Article Transfusion · November 2016 BACKGROUND: The frequency of positive test results for transfusion-transmitted infections (TTIs) among blood donors is an important index of safety; thus, appropriate monitoring is critical, particularly when there are changes in policies affecting donor s ... Full text Link to item Cite

Survey of Irradiation Practice for the Prevention of Transfusion-Associated Graft-versus-Host Disease.

Journal Article Arch Pathol Lab Med · October 2016 CONTEXT: -Transfusion-associated graft-versus-host disease is a rare, often fatal complication of cellular blood product transfusion. The requirement that at-risk groups receive irradiated products reduces the incidence of transfusion-associated graft-vers ... Full text Link to item Cite

Perception of low-titer group A plasma and potential barriers to using this product: A blood center's experience serving community and academic hospitals.

Journal Article Transfus Apher Sci · August 2016 BACKGROUND: To alleviate the shortage of AB plasma, an alternative plasma product, low-titer group A plasma (LTGAP), is now available. The product is indicated for emergency transfusions when the patient's blood group has not been identified. The product's ... Full text Link to item Cite

Changes in blood center red blood cell distributions in the era of patient blood management: the trends for collection (TFC) study.

Journal Article Transfusion · August 2016 BACKGROUND: As patient blood management becomes more widespread, fewer red blood cell (RBC) units have been transfused. This multinational study evaluated changes in blood center RBC distributions. STUDY DESIGN AND METHODS: Data on number and ABO and D gro ... Full text Link to item Cite

Motivations for donating and attitudes toward screening policies in US blood donors with viral infection.

Journal Article Transfusion · August 2016 BACKGROUND: Differences in motivating factors that contribute to the decision to donate blood between infected and uninfected donors may help to identify areas for improving donor education. STUDY DESIGN AND METHODS: As part of a risk factor study, confirm ... Full text Link to item Cite

Emerging Infections and Blood Safety in the 21st Century.

Journal Article Ann Intern Med · July 5, 2016 Full text Link to item Cite

A prospective evaluation of chronic Babesia microti infection in seroreactive blood donors.

Journal Article Transfusion · July 2016 BACKGROUND: Babesia microti is the foremost infectious risk to the US blood supply for which a Food and Drug Administration (FDA)-licensed test is unavailable for donation screening. Characterization of the antibody response to B. microti and correlation w ... Full text Link to item Cite

Serologic screening of United States blood donors for Babesia microti using an investigational enzyme immunoassay.

Journal Article Transfusion · July 2016 BACKGROUND: The tick-borne pathogen Babesia microti has become recognized as the leading infectious risk associated with blood transfusion in the United States, yet no Food and Drug Administration-licensed screening tests are currently available to mitigat ... Full text Link to item Cite

Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Seventh Special Issue.

Journal Article J Clin Apher · June 2016 The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA) Special Issue Writing Committee is charged with reviewing, updating, and categorizing indications for the evidence-based use of therapeutic apheresis in human disease. Since the ... Full text Link to item Cite

A brief motivational interview with action and coping planning components enhances motivational autonomy among volunteer blood donors.

Journal Article Transfusion · June 2016 BACKGROUND: In contrast to standard donor retention strategies (e.g., mailings, phone calls, text messages), we developed a brief telephone interview, based on motivational interviewing principles, that encourages blood donors to reflect upon their unique ... Full text Link to item Cite

Babesia screening: the importance of reporting and calibration in cost-effectiveness models.

Journal Article Transfusion · March 2016 Full text Link to item Cite

Virome Analysis of Transfusion Recipients Reveals a Novel Human Virus That Shares Genomic Features with Hepaciviruses and Pegiviruses.

Journal Article mBio · September 22, 2015 UNLABELLED: To investigate the transmission of novel infectious agents by blood transfusion, we studied changes in the virome composition of blood transfusion recipients pre- and posttransfusion. Using this approach, we detected and genetically characteriz ... Full text Link to item Cite

2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium.

Journal Article Transfusion · September 2015 On March 25 and 26, 2015, the National Heart, Lung, and Blood Institute sponsored a meeting on the State of the Science in Transfusion Medicine on the National Institutes of Health (NIH) campus in Bethesda, Maryland, which was attended by a diverse group o ... Full text Link to item Cite

Detection of bacterial contamination in apheresis platelets: is apheresis technology a factor?

Journal Article Transfusion · September 2015 BACKGROUND: Apheresis platelet (AP) contamination may be influenced by manufacturing methods because bacteria are subject to the same forces that permit separation of blood cells. This study assesses whether apheresis technology influences in-process detec ... Full text Link to item Cite

Motivating first-time, group O blood donors to return: Rationale and design of a randomized controlled trial of a post-donation telephone interview.

Journal Article Contemp Clin Trials · September 2015 First-time blood donors are essential to the US donor pool, providing nearly a third of all donations. Unfortunately, there are a wide variety of obstacles to repeat donation and new donors are extremely difficult to retain. Because each donor experiences ... Full text Link to item Cite

Retrospective analysis of community hospital red blood cell recovery procedures: improved utilization needed for effectiveness.

Journal Article Transfusion · August 2015 BACKGROUND: Perioperative blood recovery (PBR) is an important component of patient blood management. We analyzed our experience providing PBR for community hospitals to determine procedure types and clinical variables associated with efficacy and cost-eff ... Full text Link to item Cite

Early cryoprecipitate for trauma patients is feasible, but will it improve outcome?

Journal Article Br J Anaesth · July 2015 Full text Link to item Cite

Risk factors for retrovirus and hepatitis virus infections in accepted blood donors.

Journal Article Transfusion · May 2015 BACKGROUND: Risk factor surveillance among infected blood donors provides information on the effectiveness of eligibility assessment and is critical for reducing risk of transfusion-transmitted infection. STUDY DESIGN AND METHODS: American Red Cross, Blood ... Full text Link to item Cite

Acceptability and feasibility of a culturally tailored Internet-delivered intervention to promote blood donation in Blacks.

Journal Article Health Promot Pract · March 2015 INTRODUCTION: A pilot test of a computer-tailored intervention designed to promote blood donation among Blacks was conducted. METHOD: Intervention content, based on the transtheoretical model, offered participants individually and culturally tailored infor ... Full text Link to item Cite

Evaluating a program to increase blood donation among racial and ethnic minority communities in New York City.

Journal Article Transfusion · December 2014 BACKGROUND: Individuals with sickle cell disease (SCD), thalassemia, and leukemia often require frequent transfusion and run the risk of red blood cell (RBC) alloimmunization. To prevent alloimmunization or when alloimmunization is present, phenotype-match ... Full text Link to item Cite

The top clinical trial opportunities in therapeutic apheresis and neurology.

Journal Article J Clin Apher · December 2014 OBJECTIVE: The National Heart, Lung, and Blood Institute, of The National Institutes of Health, convened the 2012 State-of-the-Science Symposium in therapeutic apheresis (TA) with the goals of identifying and prioritizing future research concept proposals ... Full text Link to item Cite

The value of area-based analyses of donation patterns for recruitment strategies.

Journal Article Transfusion · December 2014 BACKGROUND: Lack of ready access to a donation site may be a potential barrier to or influence the frequency of blood donations. In this study, we applied geographic analysis to blood donor behavior and use of different donation sites. STUDY DESIGN AND MET ... Full text Link to item Cite

Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season.

Journal Article Proc Natl Acad Sci U S A · November 4, 2014 Influenza viruses typically cause the most severe disease in children and elderly individuals. However, H1N1 viruses disproportionately affected middle-aged adults during the 2013-2014 influenza season. Although H1N1 viruses recently acquired several mutat ... Full text Link to item Cite

Spotlight on pathogenesis of TRALI: HNA-3a (CTL2) antibodies.

Journal Article Blood · September 18, 2014 Human neutrophil antigen-3a (HNA-3a) antibodies contained in donor plasma can result in severe, sometimes fatal transfusion-related acute lung injury (TRALI). Recent developments in TRALI secondary to antibodies to HNA-3a antigen span diagnosis, pathophysi ... Full text Link to item Cite

The AABB recommendations for the Choosing Wisely campaign of the American Board of Internal Medicine.

Journal Article Transfusion · September 2014 Full text Link to item Cite

Determination of Babesia microti seroprevalence in blood donor populations using an investigational enzyme immunoassay.

Journal Article Transfusion · September 2014 BACKGROUND: Transfusion-transmitted babesiosis caused by Babesia microti has emerged as a significant risk to the US blood supply. This study estimated the prevalence of B. microti antibodies in blood donors using an investigational enzyme immunoassay (EIA ... Full text Link to item Cite

A comparison of adverse reaction rates for PAS C versus plasma platelet units.

Journal Article Transfusion · August 2014 BACKGROUND: Plasma constituents have been implicated in some types of platelet (PLT) transfusion reactions. Leukoreduced apheresis PLTs stored in InterSol have 65% less plasma than apheresis PLTs stored in 100% plasma (PPs). This study compared transfusion ... Full text Link to item Cite

The blood donor identity survey: a multidimensional measure of blood donor motivations.

Journal Article Transfusion · August 2014 BACKGROUND: Evidence indicates that donor identity is an important predictor of donation behavior; however, prior studies have relied on diverse, unidimensional measures with limited psychometric support. The goals of this study were to examine the applica ... Full text Link to item Cite

Current patterns of use in therapeutic apheresis: a metropolitan center experience.

Journal Article Transfusion · July 2014 Full text Link to item Cite

Red blood cell alloimmunization mitigation strategies.

Journal Article Transfus Med Rev · July 2014 Hemolytic transfusion reactions due to red blood cell (RBC) alloantibodies are a leading cause of transfusion-associated death. In addition to reported deaths, RBC alloantibodies also cause significant morbidity in the form of delayed hemolytic transfusion ... Full text Link to item Cite

Bye-bye TRALI: by understanding and innovation.

Journal Article Blood · May 29, 2014 Full text Link to item Cite

Early trauma induced coagulopathy (ETIC): prevalence across the injury spectrum.

Journal Article Injury · May 2014 INTRODUCTION: Newer studies have hypothesised about a coagulopathy that occurs early after trauma, early trauma induced coagulopathy, ETIC, and is defined by an elevated admission prothrombin time (PT). Also, referred to by some authors as acute traumatic ... Full text Link to item Cite

Policies and procedures related to testing for weak D phenotypes and administration of Rh immune globulin: results and recommendations related to supplemental questions in the Comprehensive Transfusion Medicine survey of the College of American Pathologists.

Journal Article Arch Pathol Lab Med · May 2014 CONTEXT: Advances in RHD genotyping offer an opportunity to update policies and practices for testing weak D phenotypes and administration of Rh immune globulin to postpartum women. OBJECTIVES: To repeat questions from a 1999 College of American Pathologis ... Full text Link to item Cite

Cost-effectiveness of blood donor screening for Babesia microti in endemic regions of the United States.

Journal Article Transfusion · March 2014 BACKGROUND: Babesia microti is the leading reported cause of red blood cell (RBC) transfusion-transmitted infection in the United States. Donor screening assays are in development. STUDY DESIGN AND METHODS: A decision analytic model estimated the cost-effe ... Full text Link to item Cite

Development of common metrics for donation attitude, subjective norm, perceived behavioral control, and intention for the blood donation context.

Journal Article Transfusion · March 2014 BACKGROUND: The Theory of Planned Behavior has been widely used in blood donation research, but the lack of uniform, psychometrically sound measures makes it difficult to draw firm conclusions or compare results across studies. Accordingly, the goal of thi ... Full text Link to item Cite

How we developed and use the American Society for Apheresis guidelines for therapeutic apheresis procedures.

Journal Article Transfusion · January 2014 The decision to treat a patient with therapeutic apheresis depends on multiple factors, such as what does the patient most likely have, is the diagnosis amenable to apheresis treatment, what is the harm-versus-benefit ratio of apheresis treatment in this p ... Full text Link to item Cite

American society for apheresis guidelines support use of red cell exchange transfusion for severe malaria with high parasitemia.

Journal Article Clin Infect Dis · January 2014 Full text Link to item Cite

Update on massive transfusion.

Journal Article Br J Anaesth · December 2013 Massive haemorrhage requires massive transfusion (MT) to maintain adequate circulation and haemostasis. For optimal management of massively bleeding patients, regardless of aetiology (trauma, obstetrical, surgical), effective preparation and communication ... Full text Link to item Cite

Why has Borrelia burgdorferi not been transmitted by blood transfusion?

Journal Article Transfusion · November 2013 Full text Link to item Cite

Massive transfusion: blood component ratios.

Journal Article Curr Opin Hematol · November 2013 PURPOSE OF REVIEW: This review will address recent developments in the transfusion management of massively transfused trauma patients, focusing on the use of fixed blood component ratios in massive transfusion protocols. RECENT FINDINGS: The majority of tr ... Full text Link to item Cite

The integration of high-throughput testing of blood donors for cardiovascular disease risk assessment and prevention.

Journal Article Transfus Apher Sci · October 2013 BACKGROUND AND OBJECTIVES: Some blood centers provide health screening as a public health measure and to encourage donation. The goal of the current study was to provide cardiovascular disease (CVD) screening to donors using high-throughput testing and web ... Full text Link to item Cite

How do I provide leukapheresis products? Blood center experience and evidence for process improvement.

Journal Article Transfusion · October 2013 BACKGROUND: The past few decades have seen a resurgence of interest in leukapheresis products to improve the survival of infected patients with neutropenia. These products have a short shelf life and require donor stimulation with dexamethasone before coll ... Full text Link to item Cite

The impact of a massive transfusion protocol (1:1:1) on major hepatic injuries: does it increase abdominal wall closure rates?

Conference Can J Surg · October 2013 BACKGROUND: Massive transfusion protocols (MTPs) using high plasma and platelet ratios for exsanguinating trauma patients are increasingly popular. Major liver injuries often require massive resuscitations and immediate hemorrhage control. Current publishe ... Full text Link to item Cite

Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Writing Committee of the American Society for Apheresis: the sixth special issue.

Journal Article J Clin Apher · July 2013 The American Society for Apheresis (ASFA) JCA Special Issue Writing Committee is charged with reviewing, updating and categorizating indications for therapeutic apheresis. Beginning with the 2007 ASFA Special Issue (Fourth Edition), the committee has incor ... Full text Link to item Cite

Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects: Second Edition

Book · June 11, 2013 The second edition of Transfusion Medicine and Hemostasis continues to be the only "pocket-size" quick reference for pathology residents and transfusion medicine fellows. It covers all topics in blood banking, transfusion medicine, and clinical and laborat ... Full text Cite