Scholars@Duke
Miguel Angel Materin

Miguel Angel Materin

Professor of Ophthalmology
Ophthalmology, Vitreoretinal Diseases & Surgery

Selected Publications

Yttrium-90 (90Y) brachytherapy for squamous carcinoma: Treatment of the conjunctiva, cornea, and sclera.

Journal Article Am J Ophthalmol Case Rep · December 2024 PURPOSE: Patients with conjunctival squamous cell carcinoma that present with persisting disease or recurrence following topical chemotherapy and/or surgery especially when invading the sclera are challenging to treat. Herein, we describe the use of high-d ... Full text Link to item Cite

15-Gene Expression Profile and PRAME as Integrated Prognostic Test for Uveal Melanoma: First Report of Collaborative Ocular Oncology Group Study No. 2 (COOG2.1).

Journal Article J Clin Oncol · October 2024 PURPOSEValidated and accurate prognostic testing is critical for precision medicine in uveal melanoma (UM). Our aims were to (1) prospectively validate an integrated prognostic classifier combining a 15-gene expression profile (15-GEP) and PRAME RNA expres ... Full text Link to item Cite

Melanocytic Nevus of the Superior Conjunctival Fornix: A Case Report.

Journal Article Case Rep Ophthalmol · 2024 INTRODUCTION: Conjunctival nevi are benign tumors that are commonly located at the nasal or temporal limbus and rarely in the fornix or tarsus. We report a case of a patient presenting with a solitary compound cystic nevus of the conjunctival fornix in the ... Full text Link to item Cite

Transitioning from a COMS-based plaque brachytherapy program to using eye physics plaques and plaque simulator treatment planning system: A single institutional experience.

Journal Article J Appl Clin Med Phys · May 2023 The aim of this work is to describe the implementation and commissioning of a plaque brachytherapy program using Eye Physics eye plaques and Plaque Simulator treatment planning system based on the experience of one institution with an established COMS-base ... Full text Link to item Cite

A CASE OF HIGH-RISK CILIARY BODY MELANOMA ARISING IN AN EYE AFTER RESECTION OF AN IRIDOCILIARY MELANOCYTOMA.

Journal Article Retin Cases Brief Rep · March 1, 2023 PURPOSE: To report a case of a benign iridociliary melanocytoma recurring as malignant melanoma after excision. METHODS: Observational case report with clinical data, slit-lamp examination findings, ultrasound biomicroscopy results, and histopathological a ... Full text Link to item Cite

Dual-source strength seed loading for eye plaque brachytherapy using eye physics eye plaques: A feasibility study.

Journal Article J Contemp Brachytherapy · December 2022 PURPOSE: This study quantifies the dosimetric impact of incorporating two iodine-125 (125I) seed source strengths in Eye Physics eye plaques for treatment of uveal melanoma. MATERIAL AND METHODS: Plaque Simulator was used to retrospectively plan 15 clinica ... Full text Open Access Link to item Cite

Intravitreal chemotherapy in retinoblastoma

Chapter · August 30, 2022 The chapter describes intravitreal chemotherapy for treatment of retinoblastoma, including historical aspects, currently used medications, injection protocols, efficacy, side effects and alternatives. ... Cite

OCT, OCTA and FA in retinoblastoma

Chapter · August 30, 2022 Ultrasonography and neuroimaging have been used in management of retinoblastoma for decades. In recent years, newer diagnostic modalities like optical coherence tomography (OCT), optical coherence tomography angiography (OCTA) and fluorescein angiography ( ... Cite

Improved Prognostic Precision in Uveal Melanoma through a Combined Score of Clinical Stage and Molecular Prognostication

Journal Article Ocular Oncology and Pathology · February 1, 2022 Introduction: Prognosis of uveal melanoma (UM) is assessed using clinical staging or molecular testing. Two modalities often used for prognostication are the American Joint Committee on Cancer (AJCC) staging and a tumor gene expression profile (GEP), the o ... Full text Cite

Preliminary Results of Uveal Melanoma Treated With Iodine-125 Plaques: Analysis of Disease Control and Visual Outcomes With 63 Gy to the Target Volume.

Journal Article Adv Radiat Oncol · 2022 PURPOSE: Our purpose was to review the preliminary outcomes of patients with uveal melanoma treated with iodine-125 plaques using a novel treatment planning approach. METHODS AND MATERIALS: This was a single institution, retrospective review of patients tr ... Full text Link to item Cite

Optical Coherence Tomography Angiography Microvascular Variations in Pre- and Posttreatment of Retinoblastoma Tumors.

Journal Article Ocul Oncol Pathol · October 2021 INTRODUCTION: The purpose of this study is to describe variations in microvasculature before and after treatment of treatment-naive lesions and during consolidation therapy of retinoblastoma lesions using an investigational portable optical coherence tomog ... Full text Link to item Cite

Recurrence of Primary Breast Lymphoma Presenting as Bilateral Vitreoretinal Lymphoma.

Journal Article Ocul Oncol Pathol · October 2021 PURPOSE: This report describes a case of relapsed primary breast lymphoma (PBL) presenting as vitreoretinal lymphoma (VRL). METHODS: We describe the clinical and hematopathologic findings in a patient with relapsed PBL involving the vitreous of both eyes. ... Full text Link to item Cite

CHOROIDAL MELANOMA DURING PREGNANCY: A CASE REPORT AND REVIEW OF THE LITERATURE.

Journal Article Retin Cases Brief Rep · September 1, 2021 PURPOSE: To report a case of a woman diagnosed with choroidal melanoma during pregnancy, as well as review similar cases published in the literature. The prevalence, risk factors, treatment, prognosis, and outcomes of choroidal melanoma in pregnancy are ad ... Full text Link to item Cite

Choroidal nevus with retinal invasion, clinical and imaging features.

Journal Article Am J Ophthalmol Case Rep · June 2021 PURPOSE: To report a clinically challenging case of a choroidal nevus with retinal invasion with accompanying ancillary testing. OBSERVATIONS: A 60-year-old Caucasian female was referred for a suspicious melanocytic choroidal lesion in her left eye. Ophtha ... Full text Link to item Cite

Uveal Melanoma Metastatic to the Cavernous Sinus: A Case Report.

Journal Article Ophthalmic Plast Reconstr Surg · March 2021 A woman in her early 50s previously treated 7 years prior with iodine-125 plaque brachytherapy without a biopsy for gene expression profiling for uveal melanoma in the left eye presented with a 3-week history of intermittent diplopia and headache. Ophthalm ... Full text Open Access Link to item Cite

Unique Geospatial Accumulations of Uveal Melanoma.

Journal Article Am J Ophthalmol · December 2020 PURPOSE: The main purpose of this paper was to describe the unique accumulation of cases of uveal melanoma (UM). All patients were white and did not have known occupational risk factors. From the authors' standpoint, there were no lifestyle factors in comm ... Full text Link to item Cite

Multiple Uveal Melanoma.

Journal Article Ocul Oncol Pathol · October 2020 INTRODUCTION: Multiple uveal melanoma is a rare occurrence and includes bilateral melanoma, unilateral multiple/multifocal melanoma, or melanoma with metastasis to the ipsilateral or contralateral eye. METHODS: A chart review of patients diagnosed with uve ... Full text Link to item Cite

Global Retinoblastoma Presentation and Analysis by National Income Level.

Journal Article JAMA Oncol · May 1, 2020 IMPORTANCE: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presenta ... Full text Link to item Cite

Multi-center analysis of intraocular biopsy technique and outcomes for uveal melanoma: Ocular Oncology Study Consortium report 4.

Journal Article Graefes Arch Clin Exp Ophthalmol · February 2020 PURPOSE: To investigate the relationship between surgical approach for intraocular tumor biopsy of uveal melanoma and tumor morphologic features such as size and intraocular location and the effect of these variables on diagnostic yield and biopsy outcome. ... Full text Link to item Cite

CORRELATION OF GENE EXPRESSION PROFILE STATUS AND AMERICAN JOINT COMMISSION ON CANCER STAGE IN UVEAL MELANOMA.

Journal Article Retina · February 2020 PURPOSE: To study the relationship between gene expression profile (GEP) subclass and American Joint Committee on Cancer (AJCC) stage in patients with uveal melanoma (UM). METHODS: A retrospective, multicenter study was undertaken with patients entered fro ... Full text Link to item Cite

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 4.2020, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · February 2020 Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are characterized by a progressive accumulation of leukemic cells in the peripheral blood, bone marrow, and lymphoid tissues. Treatment of CLL/SLL has evolved significantly in recent y ... Full text Link to item Cite

Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography.

Journal Article Ophthalmology · December 2019 PURPOSE: To assess macular vasculature in healthy infants and children using OCT angiography (OCTA). DESIGN: Prospective cross-sectional study. PARTICIPANTS: One hundred thirty-five normal maculae of 89 healthy infants and children (mean age, 8.5±5.3 years ... Full text Open Access Link to item Cite

Microvascular Features of Treated Retinoblastoma Tumors in Children Assessed Using OCTA.

Journal Article Ophthalmic Surg Lasers Imaging Retina · December 1, 2019 BACKGROUND AND OBJECTIVE: To describe the microvascular features of treated, clinically regressed, or reactivated retinoblastoma lesions using an investigational portable optical coherence tomography angiography (OCTA) system. PATIENTS AND METHODS: Single- ... Full text Link to item Cite

A Translucent Cystic Iris Lesion.

Journal Article JAMA Ophthalmol · August 1, 2019 Full text Link to item Cite

An Unusual Corneal Mass.

Journal Article JAMA Ophthalmol · June 1, 2019 Full text Link to item Cite

Hyperreflective Vitreous Opacities on Optical Coherence Tomography in a Patient With Bilateral Retinoblastoma.

Journal Article Ophthalmic Surg Lasers Imaging Retina · January 1, 2019 An investigational, portable spectral-domain optical coherence tomography (SD-OCT) unit revealed small hyperreflective opacities in both eyes of a patient with bilateral retinoblastoma. There was no evidence of vitreous seeding on ophthalmoscopy of either ... Full text Link to item Cite

Do Largest Basal Tumor Diameter and the American Joint Committee on Cancer's Cancer Staging Influence Prognostication by Gene Expression Profiling in Choroidal Melanoma.

Journal Article Am J Ophthalmol · November 2018 PURPOSE: To evaluate the prognostication of choroidal melanoma (CM) by the gene expression profiling (GEP) test. DESIGN: Cohort study. METHODS: Retrospective review of 293 CM patients from 2 centers. RESULTS: Of 293 patients, 132 (45%) were class 1A by GEP ... Full text Link to item Cite

Diagnostic and Therapeutic Challenges.

Journal Article Retina · November 2018 Full text Link to item Cite

CHOROIDAL TUMOR BIOPSY: A Review of the Current State and a Glance Into Future Techniques.

Journal Article Retina · September 2018 PURPOSE: To review the indications for and the methods of obtaining biopsies in eyes with uveal melanoma. In addition, this review provides recommendations for avoiding biopsy-related complications and discusses the future directions of biopsy techniques f ... Full text Link to item Cite

Successive Uveal Melanomas with Different Gene Expression Profiles in an Eye with Ocular Melanocytosis.

Journal Article Ocul Oncol Pathol · June 2018 Ocular melanocytosis portends a higher risk of uveal melanoma. Multifocal uveal melanoma has been described previously and has been associated with ocular melanocytosis. Historically, histopathology has been used to differentiate tumors; however, molecular ... Full text Link to item Cite

Acute Presentation of Mesectodermal Leiomyoma of the Ciliary Body.

Journal Article Ocul Oncol Pathol · November 2017 PURPOSE: We report a case of acutely presenting mesectodermal leiomyoma of the ciliary body in a 29-year-old female who reported waking up with swollen eyelids of the right eye and light-perception vision. The affected eye had elevated intraocular pressure ... Full text Link to item Cite

Association between Tumor Regression Rate and Gene Expression Profile after Iodine 125 Plaque Radiotherapy for Uveal Melanoma.

Journal Article Ophthalmology · October 2017 PURPOSE: Gene expression profile (GEP) testing segregates uveal melanoma (UM) into 2 main prognostic classes. It is unknown if a greater tumor regression response after iodine 125 (I125) brachytherapy correlates with class 2 GEP status. The purpose of this ... Full text Link to item Cite

Venous Loop Reveals an Occult Retinoblastoma Tumor.

Journal Article Ophthalmic Surg Lasers Imaging Retina · September 1, 2017 A 14-day-old girl presented with bilateral hereditary retinoblastoma. At 3 months, a slight bend in the superotemporal arcade was observed to have developed into a venous loop. With concern for an occult lesion along the arcade, handheld optical coherence ... Full text Link to item Cite

Topical Imiquimod in the Treatment of Conjunctival Actinic Keratosis.

Journal Article Ophthalmic Plast Reconstr Surg · 2017 Conjunctival actinic keratosis is rare and difficult to treat, as recurrences are common. Imiquimod, an immune response modulator, is currently Food and Drug Administration-approved for cutaneous actinic keratosis and superficial basal cell carcinomas. Eme ... Full text Link to item Cite

An international survey of classification and treatment choices for group D retinoblastoma.

Journal Article Int J Ophthalmol · 2017 AIM: To determine which IIRC scheme was used by retinoblastoma centers worldwide and the percentage of D eyes treated primarily with enucleation versus globe salvaging therapies as well as to correlate trends in treatment choice to IIRC version used and ge ... Full text Link to item Cite

Incorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions.

Journal Article Brachytherapy · 2017 PURPOSE: To quantify the dosimetric impact of incorporating patient-specific CT-based models rather than the conventional stylized-standard model for eye plaque brachytherapy planning. METHODS AND MATERIALS: Plaque Simulator was used to plan 16 patients us ... Full text Link to item Cite

Anterior Chamber Non-Hodgkin Lymphoma of the Iris Masquerading as Uveitis-Glaucoma-Hyphema Syndrome.

Journal Article Ocul Oncol Pathol · October 2016 PURPOSE: To report a case of iris non-Hodgkin lymphoma initially thought to be uveitis-glaucoma-hyphema (UGH) syndrome. METHODS: We reviewed the clinical, radiographic, and histopathologic findings in a patient with recurrent hyphemas and increased ocular ... Full text Link to item Cite

Free-Floating, Pigmented Cysts in the Anterior Chamber Causing Ocular Hypertension

Journal Article Ocular Oncology and Pathology · October 1, 2016 Purpose: The aim of this study was to describe the clinical and histopathological features of a 36-year-old male with hundreds of recurrent, unilateral, free-floating, pigmented cysts in the anterior chamber causing ocular hypertension. Procedures: The pat ... Full text Cite

NCCN Guidelines Insights: Melanoma, Version 3.2016.

Journal Article J Natl Compr Canc Netw · August 2016 The NCCN Guidelines for Melanoma have been significantly revised over the past few years in response to emerging data on a number of novel agents and treatment regimens. These NCCN Guidelines Insights summarize the data and rationale supporting extensive c ... Full text Link to item Cite

Melanoma, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · April 2016 This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Melanoma focuses on adjuvant therapy and treatment of in-transit disease, because substantial changes were made to the recommendations for the 2016 update. Dependin ... Full text Link to item Cite

Defining the polyposis/colorectal cancer phenotype associated with the Ashkenazi GREM1 duplication: counselling and management recommendations.

Journal Article Genet Res (Camb) · March 7, 2016 Hereditary mixed polyposis is a genetically heterogeneous, autosomal dominant condition with adenomatous, hyperplastic and juvenile polyps. We conducted a comprehensive clinical evaluation of a large Ashkenazi Jewish family with this phenotype and performe ... Full text Link to item Cite

Cyclosporine for Dry Eye Associated With Nivolumab: A Case Progressing to Corneal Perforation.

Journal Article Cornea · March 2016 PURPOSE: To present the clinical outcome of 2 cases of severe dry eye associated with Nivolumab, with 1 case progressing to corneal perforation. DESIGN: Case report. CASE 1: : A 58-year-old man with metastatic melanoma was referred for the management of se ... Full text Link to item Cite

Clinical and histologic findings in patients with uveal melanomas after taking tumor necrosis factor-α inhibitors.

Journal Article Mayo Clin Proc · November 2014 OBJECTIVE: To describe the progression of uveal melanocytic lesions to melanomas after initiation of tumor necrosis factor-α (TNF-α) inhibitors. PATIENTS AND METHODS: We report 3 cases of uveal melanoma occurring after treatment with TNF-α inhibitors, 2 fr ... Full text Link to item Cite

Benign melanocytic tumors of the uvea

Chapter · January 1, 2014 Benign melanocytic uveal tumors are generally known as nevi (also spelled as “naevi”). Nevus is a Latin word meaning birthmark or mole and is a general term for a congenital mark on the skin. In ophthalmology, the term nevus refers to an abnormal, hamartom ... Full text Cite

Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium.

Journal Article J Neurointerv Surg · November 2013 We present a description of retinoblastoma treated with supraselective intra-arterial chemotherapy, demonstrating selective delivery of the infused chemotherapeutic agent into the tumor bed by MRI. A 7-month-old presented with group E (international classi ... Full text Link to item Cite

Differentials and approach to leukocoria.

Journal Article Conn Med · March 2013 Leukocoria is an important clinical examination finding as it can be a sign of significant intraocular pathology, with the most common being retinoblastoma and congenital cataracts. The Brückner test is a quick, easy, and inexpensive way to assess the red ... Link to item Cite

Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium.

Journal Article BMJ Case Rep · November 15, 2012 We present a description of retinoblastoma treated with supraselective intra-arterial chemotherapy, demonstrating selective delivery of the infused chemotherapeutic agent into the tumor bed by MRI. A 7-month-old presented with group E (international classi ... Full text Link to item Cite

Sector laser photocoagulation for the prevention of macular edema after plaque radiotherapy for uveal melanoma: a pilot study.

Journal Article Retina · September 2012 OBJECTIVE: To investigate the role of sector laser photocoagulation for prevention of macular edema after plaque radiotherapy for uveal melanoma. METHODS: Noncomparative, pilot interventional case series. The main outcome measure was optical coherence tomo ... Full text Link to item Cite

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.

Journal Article Nat Genet · September 2012 We characterized the mutational landscape of melanoma, the form of skin cancer with the highest mortality rate, by sequencing the exomes of 147 melanomas. Sun-exposed melanomas had markedly more ultraviolet (UV)-like C>T somatic mutations compared to sun-s ... Full text Link to item Cite

Ocular neoplastic disease.

Journal Article Semin Ultrasound CT MR · February 2011 Ocular neoplasms, both primary and metastatic, may present with visual disturbance or vision loss and often are asymptomatic. Clinical ophthalmologic examination may demonstrate leukocoria, abnormal pupillary light reflex, or a mass lesion with or without ... Full text Link to item Cite

Molecular alternations in uveal melanoma.

Journal Article Curr Probl Cancer · 2011 Full text Link to item Cite

Fundus autofluorescence and optical coherence tomography findings in choroidal melanocytic lesions.

Journal Article Middle East Afr J Ophthalmol · July 2010 PURPOSE: To establish the characteristics of secondary retinal and retinal pigment epithelial (RPE) changes associated with the presence of choroidal melanoma and choroidal nevus as documented by optical coherence tomography (OCT) and fundus autofluorescen ... Full text Link to item Cite

Small choroidal melanoma with monosomy 3.

Journal Article Middle East Afr J Ophthalmol · July 2010 To report a patient with small juxtapapillary choroidal melanoma with chromosome 3 monosomy treated with I(125) plaque and transpupillary thermotherapy (TTT). A 64-year-old Caucasian male presented with painless blurred vision of the left eye. Ocular exami ... Full text Link to item Cite

Angiography of retinal and choroidal tumors

Chapter · December 1, 2009 The evaluation of intraocular tumors differs from almost all other oncologic evaluations because there is little reliance on tissue diagnosis. Definitive therapies such as enucleation and radiation are usually based on the results of ophthalmoscopy, and a ... Full text Cite

Clinical applications of optical coherence tomography in intraocular tumors

Chapter · December 1, 2009 There are several tumors that can occur in the posterior segment of the eye.1,2 They are generally classified based on the main tissue involved such as the choroid, retinal pigment epithelium (RPE), or retina. The spectrum of tumors in each tissue varies. ... Full text Cite

Periocular triamcinolone for prevention of macular edema after plaque radiotherapy of uveal melanoma: a randomized controlled trial.

Journal Article Ophthalmology · July 2009 OBJECTIVE: To determine the efficacy and safety of periocular triamcinolone acetonide (40 mg) for the prevention of macular edema in patients undergoing plaque radiotherapy for uveal melanoma. DESIGN: Prospective, randomized, controlled clinical trial. PAR ... Full text Link to item Cite

Genomic typing of uveal melanoma: Reply

Journal Article Archives of Ophthalmology · January 1, 2009 Cite

Regression of uveal melanoma after plaque radiotherapy and thermotherapy based on chromosome 3 status.

Journal Article Retina · October 2008 PURPOSE: To evaluate regression rates after plaque radiotherapy and thermotherapy of uveal melanoma with chromosome 3 monosomy versus disomy. DESIGN: Noncomparative case series. PARTICIPANTS: Two hundred and seventy patients with uveal melanoma. METHODS: F ... Full text Link to item Cite

Autofluorescence of choroidal nevus in 64 cases.

Journal Article Retina · October 2008 PURPOSE: To describe the autofluorescence features of choroidal nevi. DESIGN: Noncomparative case series. PARTICIPANTS: Sixty-four consecutive patients. METHODS: Correlation of fundus photography with autofluorescence photography. MAIN OUTCOME MEASURE: Aut ... Full text Link to item Cite

Autofluorescence of choroidal melanoma in 51 cases.

Journal Article Br J Ophthalmol · May 2008 AIM: To describe the autofluorescence features of choroidal melanoma. DESIGN: Non-comparative case series. PARTICIPANTS: 51 consecutive patients. METHODS: Standard fundus photography and autofluorescence photography (580 nm excitation, 695 nm barrier filte ... Full text Link to item Cite

Optical coherence tomography of optic disk melanocytoma in 15 cases.

Journal Article Retina · March 2008 OBJECTIVE: To describe the optical coherence tomography (OCT) features of optic disk melanocytoma. DESIGN AND PARTICIPANTS: Case series including 15 patients. MAIN OUTCOME MEASURES: OCT characteristics of the tumor. RESULTS: The mean age of the patients wa ... Full text Link to item Cite

Early macular morphological changes following plaque radiotherapy for uveal melanoma.

Journal Article Retina · February 2008 PURPOSE: To evaluate the time of onset and risk factors for the development of macular edema following plaque radiotherapy for uveal melanoma, using optical coherence tomography (OCT). METHODS: This observational case series included 135 consecutive patien ... Full text Link to item Cite

Periocular triamcinolone for prevention of macular edema after iodine 125 plaque radiotherapy of uveal melanoma.

Journal Article Retina · 2008 OBJECTIVE: To investigate the potential benefit of periocular depot triamcinolone in the prevention of macular edema after iodine 125 plaque radiotherapy for uveal melanoma. METHODS: This comparative, nonrandomized, interventional study included 87 patient ... Full text Link to item Cite

Uveal prolapse following cataract extraction simulating melanoma.

Journal Article Ophthalmic Surg Lasers Imaging · 2008 Prolapsed uveal tissue through a cataract incision can simulate any pigmented epibulbar mass, including conjunctival melanoma, extraocular extension ofa ciliary body or choroidal melanoma, and pigmented squamous cell carcinoma of the conjunctiva. The autho ... Full text Link to item Cite

Endolymphatic sac tumor as initial manifestation of von hippel-lindau syndrome.

Journal Article Retin Cases Brief Rep · 2008 PURPOSE: To report endolymphatic sac tumor (ELST) as the initial finding in von Hippel-Lindau (VHL) syndrome. METHODS: Case report. RESULTS: A 4-year-old boy presented in February 2001 with right hearing loss and seventh nerve palsy from ELST. Genetic anal ... Full text Link to item Cite

Optical coherence tomography of choroidal osteoma in 22 cases: evidence for photoreceptor atrophy over the decalcified portion of the tumor.

Journal Article Ophthalmology · December 2007 PURPOSE: To evaluate the retinal status overlying choroidal osteoma using optical coherence tomography (OCT). DESIGN: Retrospective noncomparative case series. PARTICIPANTS: Twenty-two eyes with choroidal osteoma. METHODS: Choroidal osteoma was studied wit ... Full text Link to item Cite

Small choroidal melanoma with chromosome 3 monosomy on fine-needle aspiration biopsy.

Journal Article Ophthalmology · October 2007 PURPOSE: To evaluate the presence of chromosome 3 monosomy in small choroidal melanoma using fine-needle aspiration biopsy (FNAB). DESIGN: Noncomparative case series. PARTICIPANTS: Fifty-six patients with small choroidal melanoma measuring 3 mm or less in ... Full text Link to item Cite

Autofluorescence of orange pigment overlying small choroidal melanoma.

Journal Article Retina · October 2007 PURPOSE: To describe the autofluorescence features of orange pigment (intracellular lipofuscin) overlying small presumed choroidal melanomas. METHODS: The diagnostic testing results (fluorescein angiography, optical coherence tomography, and fundus autoflu ... Full text Link to item Cite

Brown trabeculectomy bleb from necrotic iris melanocytoma.

Journal Article Acta Ophthalmol Scand · August 2007 Full text Link to item Cite

Chromosome 3 analysis of uveal melanoma using fine-needle aspiration biopsy at the time of plaque radiotherapy in 140 consecutive cases: the Deborah Iverson, MD, Lectureship.

Journal Article Arch Ophthalmol · August 2007 OBJECTIVE: To evaluate the feasibility of genetic testing of uveal melanoma using fine-needle aspiration biopsy (FNAB). METHODS: We reviewed the clinical records of all patients of the Ocular Oncology Service at Wills Eye Hospital with the diagnosis of uve ... Full text Link to item Cite

Brown trabeculectomy bleb from necrotic iris melanocytoma

Journal Article ACTA OPHTHALMOLOGICA SCANDINAVICA · August 1, 2007 Full text Link to item Cite

Chromosome 3 analysis of uveal melanoma using fine-needle aspiration biopsy at the time of plaque radiotherapy in 140 consecutive cases.

Journal Article Trans Am Ophthalmol Soc · 2007 PURPOSE: To evaluate the feasibility of genetic testing of uveal melanoma using fine-needle aspiration biopsy (FNAB). METHODS: Noncomparative case series of 140 patients in which FNAB was performed immediately prior to plaque radiotherapy. The specimen was ... Link to item Cite

Optical coherence tomography of retinal astrocytic hamartoma in 15 cases.

Journal Article Ophthalmology · September 2006 OBJECTIVE: To describe the features of retinal astrocytic hamartoma using optical coherence tomography (OCT). DESIGN: Retrospective, observational, noncomparative case series. PARTICIPANTS: Fifteen consecutive eyes from 14 patients with retinal astrocytic ... Full text Link to item Cite

Progressive enlargement of cavity within melanoma masquerading as iris cyst.

Journal Article Cornea · August 2006 PURPOSE: To describe progressive enlargement of intralesional cavities within a mass that masqueraded clinically as an iris pigment epithelial cyst for 2 years but later proved to be a melanoma. METHODS: An 81-year-old woman developed asymptomatic focal el ... Full text Link to item Cite

Photoreceptor loss overlying congenital hypertrophy of the retinal pigment epithelium by optical coherence tomography.

Journal Article Ophthalmology · April 2006 OBJECTIVE: To describe the cross-sectional retinal anatomy overlying congenital hypertrophy of the retinal pigment epithelium (CHRPE) using optical coherence tomography (OCT). DESIGN: Retrospective, observational, noncomparative case series. PARTICIPANTS: ... Full text Link to item Cite

Intravitreal triamcinolone acetonide for acute radiation papillopathy.

Journal Article Retina · 2006 OBJECTIVE: To evaluate intravitreal triamcinolone acetonide for patients with visually symptomatic acute radiation-induced papillopathy. METHODS: In a prospective, nonrandomized, single-center case series, intravitreal triamcinolone acetonide (4 mg/0.1 mL) ... Full text Link to item Cite

Review of optical coherence tomography for intraocular tumors.

Journal Article Curr Opin Ophthalmol · June 2005 PURPOSE OF REVIEW: Optical coherence tomography has assumed an important role in the management of numerous ocular conditions. With regard to ocular oncology, optical coherence tomography can illustrate retinal changes overlying choroidal tumors. Some of t ... Full text Link to item Cite

Expanding MIRAgel scleral buckle simulating an orbital tumor in four cases.

Journal Article Ophthalmic Plast Reconstr Surg · January 2005 PURPOSE: To describe four patients with an enlarging orbital mass from a swollen MIRAgel scleral buckle that simulated an orbital neoplasm. METHODS: In a retrospective, single-center case series at the Ocular Oncology Service at Wills Eye Hospital of Thoma ... Full text Link to item Cite

Intravitreal triamcinolone acetonide for radiation maculopathy after plaque radiotherapy for choroidal melanoma.

Journal Article Retina · 2005 OBJECTIVE: To evaluate the effect of intravitreal triamcinolone acetonide on patients with visually symptomatic radiation-induced maculopathy after plaque radiotherapy for choroidal melanoma. DESIGN: In this prospective, nonrandomized, single-center case s ... Full text Link to item Cite

Resolution of advanced cystoid macular edema following photodynamic therapy for choroidal hemangioma.

Journal Article Ophthalmic Surg Lasers Imaging · 2005 A 45-year-old man was referred for 2 months of decreasing vision in his left eye. His visual acuity was 20/200 secondary to a subtle juxtapapillary choroidal hemangioma producing profound cystoid macular edema, with the affected retina measuring 330 micron ... Link to item Cite

Optical coherence tomography of choroidal nevus in 120 patients.

Journal Article Retina · 2005 OBJECTIVE: To describe the optical coherence tomography (OCT) findings of choroidal nevi. METHODS: Retrospective, single-center case series of 120 eyes of 120 consecutive patients with choroidal nevi who were evaluated by OCT. Diagnostic imaging was perfor ... Full text Link to item Cite

Optical coherence tomography of tumors of the retina and retinal pigment epithelium

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · January 1, 2005 Link to item Cite

Clinical factors in the identification of small choroidal melanoma.

Journal Article Can J Ophthalmol · June 2004 The detection and treatment of choroidal melanoma early in its natural course is critical to providing the patient with the best prognosis. Studies of tumour doubling time have indicated that metastasis from choroidal melanoma can occur quite early in the ... Full text Link to item Cite

Changing concepts in management of circumscribed choroidal hemangioma: The 2003 J. Howard Stokes Lecture, part 1

Journal Article Ophthalmic Surgery Lasers and Imaging · January 1, 2004 BACKGROUND AND OBJECTIVE: To review trends in the management of circumscribed choroidal hemangioma (CCH) and to propose treatment guidelines based on review of recent literature and the authors' personal experience with more than 250 cases. METHOD: The Eng ... Full text Cite

Changing concepts in management of circumscribed choroidal hemangioma: the 2003 J. Howard Stokes Lecture, Part 1.

Conference Ophthalmic Surg Lasers Imaging · 2004 BACKGROUND AND OBJECTIVE: To review trends in the management of circumscribed choroidal hemangioma (CCH) and to propose treatment guidelines based on review of recent literature and the authors' personal experience with more than 250 METHOD: The English-la ... Link to item Cite

Optical coherence tomography in children: analysis of 44 eyes with intraocular tumors and simulating conditions.

Journal Article J Pediatr Ophthalmol Strabismus · 2004 PURPOSE: To investigate the role of optical coherence tomography (OCT) in the evaluation of fundus tumors and simulating lesions in children. PATIENTS AND METHODS: We report the results of a retrospective single-center case series of 44 eyes of 44 children ... Full text Link to item Cite

Panoramic imaging of the ocular fundus.

Journal Article Arch Ophthalmol · November 2003 Full text Link to item Cite

Combined plaque radiotherapy and transpupillary thermotherapy for choroidal melanoma: Tumor control and treatment complications in 270 consecutive patients

Journal Article Archives of Ophthalmology · January 1, 2002 Objective: To evaluate tumor control and treatment complications following plaque radiotherapy combined with transpupillary thermotherapy for choroidal melanoma. Design: Prospective noncomparative interventional case series. Intervention: All patients rece ... Full text Cite

Factors associated with elevated intraocular pressure in eyes with iris melanoma.

Journal Article Br J Ophthalmol · June 2001 AIM: To identify clinical factors associated with secondary elevated intraocular pressure (IOP) in eyes with iris malignant melanoma METHODS: A retrospective case series of 169 consecutive patients with microscopically confirmed iris malignant melanoma. Th ... Full text Link to item Cite

Adenoma of the retinal pigment epithelium simulating a juxtapapillary choroidal neovascular membrane.

Journal Article Arch Ophthalmol · February 2001 We report a case of an adenoma of the retinal pigment epithelium that clinically simulated a juxtapapillary choroidal neovascular membrane in a 60-year-old man. Fluorescein angiography supported the diagnosis of a juxtapapillary choroidal neovascular membr ... Link to item Cite

Iris melanoma: risk factors for metastasis in 169 consecutive patients.

Journal Article Ophthalmology · January 2001 OBJECTIVE: To identify risk factors that predict distant metastases of iris malignant melanoma. DESIGN: Retrospective case series. PARTICIPANTS: The participants included 169 consecutive patients with microscopically confirmed iris malignant melanoma manag ... Full text Link to item Cite

BILATERAL DIFFUSE UVEAL MELANOCYTIC PROLIFERATION: A CASE REPORT.

Journal Article Retin Cases Brief Rep PURPOSE: To report a case of bilateral diffuse uveal melanocytic proliferation (BDUMP) in the setting of metastatic ovarian cancer. METHODS: In this observational case report, a 59-year-old woman presented with bilateral worsening vision and photophobia. S ... Full text Link to item Cite