Scholars@Duke
Anthony Nanlin Kuo

Anthony Nanlin Kuo

Professor of Ophthalmology
Ophthalmology, Corneal Diseases
anthony.kuo@duke.edu
Box 3802 Med Ctr, Durham, NC 27710
2351 Erwin Rd, Durham, NC 27710

Selected Publications

Distortion-Corrected Posterior Ocular Shape in Myopic Eyes Assessed by Ultrawide OCT Detects Deformations Associated With Vision-Threatening Changes.

Journal Article Invest Ophthalmol Vis Sci · November 4, 2024 PURPOSE: To develop a quantitative tool for assessing the posterior ocular shape using widefield, volumetric optical coherence tomography (OCT) in eyes with myopia. METHODS: This observational, cross-sectional study included 178 eyes from 113 participants. ... Full text Link to item Cite

Safety and Efficacy of Epithelium-Off Corneal Collagen Cross-Linking for the Treatment of Corneal Ectasia: A Report by the American Academy of Ophthalmology.

Journal Article Ophthalmology · October 2024 PURPOSE: To review the evidence on the safety and effectiveness of epithelium-off corneal collagen cross-linking (CXL) for the treatment of progressive corneal ectasia. METHODS: A literature search of the PubMed database was most recently conducted in Marc ... Full text Link to item Cite

Efficacy of Amniotic Membrane Grafting for the Treatment of Chemical and Thermal Ocular Surface Injuries: A Report by the American Academy of Ophthalmology.

Journal Article Ophthalmology · October 2024 ObjectiveTo evaluate the published literature on the efficacy of amniotic membrane grafting (AMG) in the management of acute chemical and thermal ocular surface burns with respect to the rate of corneal re-epithelialization and improvement of visu ... Full text Cite

Outcomes and Complications of Limbal Stem Cell Allograft Transplantation: A Report by the American Academy of Ophthalmology.

Journal Article Ophthalmology · September 2024 PURPOSE: To review the published literature on the safety and outcomes of keratolimbal allograft (KLAL) transplantation and living-related conjunctival limbal allograft (lr-CLAL) transplantation for bilateral severe/total limbal stem cell deficiency (LSCD) ... Full text Link to item Cite

Identification of Keratoconus-Related Phenotypes in Three Ppip5k2 Mouse Models.

Journal Article Invest Ophthalmol Vis Sci · June 3, 2024 PURPOSE: It is necessary to establish a mouse model of keratoconus (KC) for research and therapy. We aimed to determine corneal phenotypes in 3 Ppip5k2 mouse models. METHODS: Central corneal thickness (CCT) was determined using spectral domain optical cohe ... Full text Link to item Cite

Spiral scanning improves subject fixation in widefield retinal imaging.

Journal Article Opt Lett · May 1, 2024 Point scanning retinal imaging modalities, including confocal scanning light ophthalmoscopy (cSLO) and optical coherence tomography, suffer from fixational motion artifacts. Fixation targets, though effective at reducing eye motion, are infeasible in some ... Full text Link to item Cite

RobOCTNet: Robotics and Deep Learning for Referable Posterior Segment Pathology Detection in an Emergency Department Population.

Journal Article Transl Vis Sci Technol · March 1, 2024 PURPOSE: To evaluate the diagnostic performance of a robotically aligned optical coherence tomography (RAOCT) system coupled with a deep learning model in detecting referable posterior segment pathology in OCT images of emergency department patients. METHO ... Full text Link to item Cite

Advanced Corneal Imaging in Keratoconus: A Report by the American Academy of Ophthalmology.

Journal Article Ophthalmology · January 2024 PURPOSE: To review the published literature on the diagnostic capabilities of the newest generation of corneal imaging devices for the identification of keratoconus. METHODS: Corneal imaging devices studied included tomographic platforms (Scheimpflug photo ... Full text Link to item Cite

Hybrid spiral scanning in a double-clad fiber-based handheld confocal scanning light ophthalmoscope.

Journal Article Biomed Opt Express · October 1, 2023 High-speed, accessible, and robust in vivo imaging of the human retina is critical for screening of retinal pathologies, such as diabetic retinopathy, age-related macular degeneration, and others. Scanning light ophthalmoscopy (SLO) is a retinal imaging mo ... Full text Link to item Cite

Erratum: Methods for real-time feature-guided image fusion of intrasurgical volumetric optical coherence tomography with digital microscopy: publisher's note.

Journal Article Biomed Opt Express · October 1, 2023 [This corrects the article on p. 3308 in vol. 14, PMID: 37497493.]. ... Full text Link to item Cite

Methods for real-time feature-guided image fusion of intrasurgical volumetric optical coherence tomography with digital microscopy.

Journal Article Biomed Opt Express · July 1, 2023 4D-microscope-integrated optical coherence tomography (4D-MIOCT) is an emergent multimodal imaging technology in which live volumetric OCT (4D-OCT) is implemented in tandem with standard stereo color microscopy. 4D-OCT provides ophthalmic surgeons with man ... Full text Link to item Cite

Visualization of surgical maneuvers using intraoperative real-time volumetric optical coherence tomography.

Journal Article Biomed Opt Express · July 1, 2023 Ophthalmic microsurgery is traditionally performed using stereomicroscopes and requires visualization and manipulation of sub-millimeter tissue structures with limited contrast. Optical coherence tomography (OCT) is a non-invasive imaging modality that can ... Full text Link to item Cite

Robotic Optical Coherence Tomography Retinal Imaging for Emergency Department Patients: A Pilot Study for Emergency Physicians' Diagnostic Performance.

Journal Article Ann Emerg Med · April 2023 STUDY OBJECTIVE: To evaluate the diagnostic performance of emergency physicians' interpretation of robotically acquired retinal optical coherence tomography images for detecting posterior eye abnormalities in patients seen in the emergency department (ED). ... Full text Link to item Cite

Robotic Optical Coherence Tomography of Human Subjects with Posture-Invariant Head and Eye Alignment in Six Degrees of Freedom.

Conference Int Symp Med Robot · April 2023 Ophthalmic optical coherence tomography (OCT) has achieved remarkable clinical success but remains sequestered in ophthalmology specialty offices. Recently introduced robotic OCT systems seek to expand patient access but fall short of their full potential ... Full text Link to item Cite

Systematic analysis of levels of evidence supporting American Academy of Ophthalmology Preferred Practice Pattern guidelines, 2012-2021.

Journal Article BMC Ophthalmol · March 31, 2023 BACKGROUND: Despite the increased emphasis on evidence-based medicine, the current state of evidence behind ophthalmology clinical practice guidelines is unknown. The purpose of this systematic analysis was to understand the levels of evidence (LOE) suppor ... Full text Link to item Cite

Dual modality handheld adaptive optics optical coherence tomography probe for in vivo 3-D photoreceptor imaging

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2023 Adaptive optics optical coherence tomography (AO-OCT) has allowed for the reliable 3-D imaging of individual retinal cells. The current AO-OCT systems are limited to tabletop implementation due to their size and complexity. This work describes the design a ... Full text Cite

Adaptive point-scan imaging beyond the frame rate–resolution limit with scene-reactive scan trajectories

Journal Article Optica · November 20, 2022 Point-scanned imaging modalities such as optical coherence tomography (OCT) are subject to frame rate limits governed by the image resolution, sampling rate, and scanner dynamics. For scenes with dynamic features on static backgrounds, adaptive scanning es ... Full text Cite

Optical coherence tomography refraction and optical path length correction for image-guided corneal surgery.

Journal Article Biomed Opt Express · September 1, 2022 Optical coherence tomography (OCT) may be useful for guidance of ocular microsurgeries such as deep anterior lamellar keratoplasty (DALK), a form of corneal transplantation that requires delicate insertion of a needle into the stroma to approximately 90% o ... Full text Link to item Cite

Practice Patterns of Fundoscopic Examination for Diabetic Retinopathy Screening in Primary Care.

Journal Article JAMA Netw Open · June 1, 2022 IMPORTANCE: Primary care professionals (PCPs) have a central role in screening for diabetic retinopathy (DR), especially in settings where access to specialty eye care is limited. Data on current DR screening practice patterns in primary care are needed to ... Full text Link to item Cite

Data-Driven Modelling and Control for Robot Needle Insertion in Deep Anterior Lamellar Keratoplasty.

Journal Article IEEE Robot Autom Lett · April 2022 Deep anterior lamellar keratoplasty (DALK) is a technique for cornea transplantation which is associated with reduced patient morbidity. DALK has been explored as a potential application of robot microsurgery because the small scales, fine control requirem ... Full text Link to item Cite

Nonlinear distortion correction for posterior eye segment optical coherence tomography with application to tree shrews.

Journal Article Biomed Opt Express · February 1, 2022 We propose an empirical distortion correction approach for optical coherence tomography (OCT) devices that use a fan-scanning pattern to image the posterior eye segment. Two types of reference markers were used to empirically estimate the distortion correc ... Full text Link to item Cite

Robotically-Aligned Optical Coherence Tomography with Gaze Tracking for Live Image Montaging of the Retina

Conference Proceedings - IEEE International Conference on Robotics and Automation · January 1, 2022 Optical coherence tomography (OCT) has revolutionized diagnostics in ophthalmology. However, it requires pa-tient cooperation to fixate on multiple targets and stabilize their head utilizing both chin and forehead rests. Patient cooperation is particularly ... Full text Cite

Robotically aligned optical coherence tomography with 5 degree of freedom eye tracking for subject motion and gaze compensation.

Journal Article Biomed Opt Express · December 1, 2021 Optical coherence tomography (OCT) has revolutionized diagnostics in ophthalmology. However, OCT requires a trained operator and patient cooperation to carefully align a scanner with the subject's eye and orient it in such a way that it images a desired re ... Full text Link to item Cite

Ultrawide field, distortion-corrected ocular shape estimation with MHz optical coherence tomography (OCT).

Journal Article Biomedical optics express · September 2021 Ocular deformation may be associated with biomechanical alterations in the structures of the eye, especially the cornea and sclera in conditions such as keratoconus, congenital glaucoma, and pathological myopia. Here, we propose a method to estimate ocular ... Full text Cite

Contactless optical coherence tomography of the eyes of freestanding individuals with a robotic scanner.

Journal Article Nat Biomed Eng · July 2021 Clinical systems for optical coherence tomography (OCT) are used routinely to diagnose and monitor patients with a range of ocular diseases. They are large tabletop instruments operated by trained staff, and require mechanical stabilization of the head of ... Full text Link to item Cite

Characteristics of myopic traction maculopathy in myopic Singaporean adults.

Journal Article Br J Ophthalmol · April 2021 PURPOSE: To investigate the characteristics, risk factors and visual impact of myopic traction maculopathy (MTM) among adults with myopia in Singapore. METHODS: We analysed 3316 myopic eyes of adults aged over 40 years who participated in the Singapore Epi ... Full text Link to item Cite

QUANTITATIVE TOPOGRAPHIC CURVATURE MAPS OF THE POSTERIOR EYE UTILIZING OPTICAL COHERENCE TOMOGRAPHY.

Journal Article Retina · April 1, 2021 PURPOSE: Deformations of the retina such as staphylomas in myopia or scleral flattening in high intracranial pressure can be challenging to quantify with en face imaging. We describe an optical coherence tomography-based method for the generation of quanti ... Full text Open Access Link to item Cite

In vivo quantitative analysis of anterior chamber white blood cell mixture composition using spectroscopic optical coherence tomography.

Journal Article Biomed Opt Express · April 1, 2021 Anterior uveitis is the most common form of intraocular inflammation, and one of its main signs is the presence of white blood cells (WBCs) in the anterior chamber (AC). Clinically, the true composition of cells can currently only be obtained using AC para ... Full text Link to item Cite

Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide-field optical coherence tomography in Singapore adults with high myopia.

Journal Article Acta Ophthalmol · March 2021 PURPOSE: To investigate the prevalence and risk factors of posterior staphyloma using wide-field optical coherence tomography (WF-OCT) in adults with high myopia in Singapore. DESIGN: Population-based cross-sectional study. METHODS: Adults with spherical e ... Full text Link to item Cite

MRI of posterior eye shape and its associations with myopia and ethnicity.

Journal Article Br J Ophthalmol · September 2020 PURPOSE: To evaluate posterior eye shape variations across a wide refractive error range using brain MRI in a multiethnic cohort. METHODS: Adult subjects in the multiethnic Singapore Epidemiology of Eye Disease study were included. Spherical equivalent (SE ... Full text Link to item Cite

Intraocular Lens Implantation in the Absence of Zonular Support: An Outcomes and Safety Update: A Report by the American Academy of Ophthalmology.

Journal Article Ophthalmology · September 2020 PURPOSE: To review the published literature on the visual acuity results and complications of different surgical techniques for intraocular lens (IOL) implantation in the absence of zonular support. METHODS: Peer-reviewed literature searches were conducted ... Full text Link to item Cite

Multimodal handheld adaptive optics scanning laser ophthalmoscope.

Journal Article Opt Lett · September 1, 2020 Non-confocal adaptive optics scanning laser ophthalmoscopy (AOSLO) has enhanced the study of human retinal photoreceptors by providing complementary information to standard confocal AOSLO images. Previously we developed the first confocal handheld AOSLO (H ... Full text Link to item Cite

Optical Coherence Tomography-Guided Robotic Ophthalmic Microsurgery via Reinforcement Learning from Demonstration.

Journal Article IEEE Trans Robot · August 2020 Ophthalmic microsurgery is technically difficult because the scale of required surgical tool manipulations challenge the limits of the surgeon's visual acuity, sensory perception, and physical dexterity. Intraoperative optical coherence tomography (OCT) im ... Full text Link to item Cite

Optical Coherence Tomography Guided Robotic Needle Insertion for Deep Anterior Lamellar Keratoplasty.

Journal Article IEEE Trans Biomed Eng · July 2020 OBJECTIVE: Deep anterior lamellar keratoplasty (DALK) significantly reduces the post-transplantation morbidity in patients eligible for partial-thickness cornea grafts. The popular "big bubble" technique for DALK is so challenging, however, that a signific ... Full text Link to item Cite

Intraoperative aberrometry vs modern preoperative formulas in predicting intraocular lens power.

Journal Article J Cataract Refract Surg · June 2020 PURPOSE: To compare the outcomes of an intraoperative aberrometer (ORA) to the Barrett Universal II (Barrett II) and Hill-RBF 2.0 (Hill-RBF) intraocular lens (IOL) power calculation formulas. SETTING: Duke University Eye Center, Durham, North Carolina, USA ... Full text Link to item Cite

Toward Autonomous Robotic Micro-Suturing using Optical Coherence Tomography Calibration and Path Planning

Journal Article Proceedings - IEEE International Conference on Robotics and Automation · May 1, 2020 Robotic automation has the potential to assist human surgeons in performing suturing tasks in microsurgery, and in order to do so a robot must be able to guide a needle with sub-millimeter precision through soft tissue. This paper presents a robotic suturi ... Full text Cite

Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study.

Journal Article Invest Ophthalmol Vis Sci · April 9, 2020 PURPOSE: To examine the 6-year incidence, progression, associated risk factors, and impact of myopic macular degeneration (MMD) in a myopic population in Singapore. METHODS: We examined myopic (spherical equivalent ≤-0.5 diopters) adults (N = 2157 persons ... Full text Link to item Cite

Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease: A Report by the American Academy of Ophthalmology.

Journal Article Ophthalmology · January 2020 PURPOSE: To describe the safety and effectiveness of using autologous serum-based eye drops for the treatment of severe dry eye and persistent corneal epithelial defect. METHODS: Literature searches of the PubMed and Cochrane Library databases were conduct ... Full text Link to item Cite

Topography and pachymetry maps for mouse corneas using optical coherence tomography.

Journal Article Exp Eye Res · January 2020 The majority of the eye's refractive power lies in the cornea, and pathological changes in its shape can affect vision. Small animal models offer an unparalleled degree of control over genetic and environmental factors that can help elucidate mechanisms of ... Full text Link to item Cite

Wavefront sensorless multimodal handheld adaptive optics scanning laser ophthalmoscope for in vivo imaging of human retinal cones

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 Adaptive optics scanning laser ophthalmoscopy (AOSLO) has advanced the study of retinal structure and function by enabling in vivo imaging of individual photoreceptors. Most implementations of AOSLOs are large, complex tabletop systems, thereby preventing ... Full text Cite

Robotically Aligned OCT Imaging with Clinically Relevant Fields of View on the Retina

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Mouse corneal transplant evaluation with topography and pachymetry using OCT

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Detection of Retinal Detachment by ED Clinicians on OCT Images versus Fundus Photos

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Empirical Distortion Correction for Posterior Segment SD-OCT Images in Small Animals

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Robotically Aligned OCT for Subject Eye Translation and Rotation Compensation

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Microscope-Integrated OCT-Based Topography Maps for Corneal Astigmatism Assessment

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus.

Journal Article Sci Rep · December 18, 2019 Keratoconus (KC) is the most common corneal ectatic disorder affecting >300,000 people in the US. KC normally has its onset in adolescence, progressively worsening through the third to fourth decades of life. KC patients report significant impaired vision- ... Full text Link to item Cite

In vivo corneal endothelium imaging using ultrahigh resolution OCT.

Journal Article Biomed Opt Express · November 1, 2019 We investigate the influence of optical coherence tomography (OCT) system resolution on high-quality in vivo en face corneal endothelial cell images of the monkey eye, to allow for quantitative analysis of cell density. We vary the lateral resolution of th ... Full text Link to item Cite

Influence of corneal diameter on surgically induced astigmatism in small-incision cataract surgery.

Journal Article Can J Ophthalmol · October 2019 OBJECTIVE: Clear corneal incisions (CCI) in cataract surgery create a variable amount of surgically induced astigmatism (SIA). As refractive outcomes become increasingly important, it is necessary to understand factors that impact SIA and refractive surpri ... Full text Link to item Cite

An Update of Eye Shape and Myopia.

Journal Article Eye Contact Lens · September 2019 Myopia is one of the most prevalent eye diseases, and its advanced form, high myopia, is a leading cause of subsequent pathologic myopia, which in turn results in an increased risk of retinal diseases. The prevalence of myopia and high myopia is 28.3% and ... Full text Link to item Cite

Ocular anterior chamber blood cell population differentiation using spectroscopic optical coherence tomography.

Journal Article Biomed Opt Express · July 1, 2019 There is potential clinical significance in identifying cellular responses in the anterior chamber (AC) of the eye, which can indicate hyphema (an accumulation of red blood cells [RBCs]) or aberrant intraocular inflammation (an accumulation of white blood ... Full text Link to item Cite

True retinal topography: quantitative curvature maps of the retina using OCT

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Curvature Differences in Myopic Eyes With and Without Staphyloma using OCT

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Robotically Aligned OCT Scanner for Automated Patient Tracking Retinal Imaging

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

PPIP5K2 mutations & Keratoconus in Human Patients and Mouse Models

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Mouse corneal topography, pachymetry, and keratometry utilizing OCT with keratometer validation

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Automatic optical coherence tomography imaging of stationary and moving eyes with a robotically-aligned scanner

Conference Proceedings - IEEE International Conference on Robotics and Automation · May 1, 2019 Optical coherence tomography (OCT) has found great success in ophthalmology where it plays a key role in screening and diagnostics. Clinical ophthalmic OCT systems are typically deployed as tabletop instruments that require chinrest stabilization and train ... Full text Cite

Wide-field whole eye OCT system with demonstration of quantitative retinal curvature estimation.

Journal Article Biomed Opt Express · January 1, 2019 Current conventional clinical OCT systems image either only the anterior or the posterior eye during a single acquisition. This localized imaging limits conventional OCT's use for characterizing global ocular morphometry and biometry, which requires knowle ... Full text Open Access Link to item Cite

Characterization of Corneal Donor Tissue Lesions by Anterior Segment Optical Coherence Tomography Compared With Eye Bank Technician Slit-Lamp Examination.

Journal Article Cornea · October 2018 PURPOSE: To compare anterior segment spectral-domain optical coherence tomography (OCT) with eye bank technician slit-lamp examination (SLE) in characterizing lesions in donor corneas. METHODS: Twenty-nine donor corneas identified by eye bank technicians t ... Full text Link to item Cite

Constant linear velocity spiral scanning for near video rate 4D OCT ophthalmic and surgical imaging with isotropic transverse sampling.

Journal Article Biomed Opt Express · October 1, 2018 Ultrahigh speed optical coherence tomography (OCT) systems with >100 kHz A-scan rates can generate volumes rapidly with minimal motion artifacts and are well suited for 4D imaging (volumes through time) applications such as intra-operative imaging. In such ... Full text Link to item Cite

Handheld Adaptive Optics Scanning Laser Ophthalmoscope.

Journal Article Optica · September 20, 2018 Adaptive optics scanning laser ophthalmoscopy (AOSLO) has enabled in vivo visualization and enhanced understanding of retinal structure and function. Current generation AOSLOs have a large footprint and are mainly limited to imaging cooperative adult subje ... Full text Link to item Cite

Real-Time Image-Guided Cooperative Robotic Assist Device for Deep Anterior Lamellar Keratoplasty

Conference Proceedings - IEEE International Conference on Robotics and Automation · September 10, 2018 Deep anterior lamellar keratoplasty (DALK) is a promising technique for corneal transplantation that avoids the chronic immunosuppression comorbidities and graft rejection risk associated with penetrating keratoplasty (PKP), the standard procedure. In DALK ... Full text Cite

OCT-Guided Cooperative Robotic Deep Anterior Lamellar Keratoplasty

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Real- time Corneal Segmentation and 3D Needle Tracking in Intrasurgical OCT

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

MRI imaging of eye shape and associations with myopia in Singapore adults

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Real-time corneal segmentation and 3D needle tracking in intrasurgical OCT.

Journal Article Biomed Opt Express · June 1, 2018 Ophthalmic procedures demand precise surgical instrument control in depth, yet standard operating microscopes supply limited depth perception. Current commercial microscope-integrated optical coherence tomography partially meets this need with manually-pos ... Full text Link to item Cite

Real-time visualization and interaction with static and live optical coherence tomography volumes in immersive virtual reality.

Journal Article Biomed Opt Express · June 1, 2018 Virtual reality (VR) head-mounted displays are an attractive technology for viewing intrasurgical optical coherence tomography (OCT) volumes because they liberate surgeons from microscope oculars. We demonstrate real-time, interactive viewing of OCT volume ... Full text Link to item Cite

Volumetric Measurement of Subretinal Blebs Using Microscope-Integrated Optical Coherence Tomography.

Journal Article Transl Vis Sci Technol · April 2018 PURPOSE: We advance studies of subretinal treatments by developing a microscope-integrated optical coherence tomography (MIOCT) image-based method for measuring the volume of therapeutics delivered into the subretinal space. METHODS: A MIOCT image-based vo ... Full text Link to item Cite

Descemet Membrane Endothelial Keratoplasty: Safety and Outcomes: A Report by the American Academy of Ophthalmology.

Journal Article Ophthalmology · February 2018 PurposeTo review the published literature on the safety and outcomes of Descemet membrane endothelial keratoplasty (DMEK) for the surgical treatment of corneal endothelial dysfunction.MethodsLiterature searches were last conducted in the ... Full text Cite

Anterior chamber blood cell differentiation using spectroscopic optical coherence tomography

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 There is great clinical importance in identifying cellular responses in the anterior chamber (AC) which can indicate signs of hyphema (an accumulation of red blood cells (RBCs)) or aberrant intraocular inflammation (an accumulation of white blood cells (WB ... Full text Cite

Teleoperating robots from arbitrary viewpoints in surgical contexts

Conference IEEE International Conference on Intelligent Robots and Systems · December 13, 2017 Intraoperative 3D imaging has great potential for enhancing surgical visualization. This is especially so in ophthalmic surgery where live volumetric imaging from optical coherence tomography systems recently incorporated into surgical microscopes has free ... Full text Cite

Retinal imaging in human autopsy eyes using a custom optical coherence tomography periscope.

Journal Article Biomed Opt Express · September 1, 2017 Age-related macular degeneration (AMD) is a major cause of vision loss in the elderly. To better study the pathobiology of AMD, postmortem eyes offer an excellent opportunity to correlate optical coherence tomography (OCT) imaging characteristics with hist ... Full text Link to item Cite

Ocular morphometry from wide-field, whole eye OCT compared to MRI and PCI

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Immersive Virtual Reality for Live Volumetric Optical Coherence Tomography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Microscope-integrated OCT at 800 kHz line rate for high speed 4D imaging of ophthalmic surgery

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Assessment of opacities in donor corneas using optical coherence tomography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Intraoperative 4-Dimensional Microscope-Integrated Optical Coherence Tomography-Guided 27-Gauge Transvitreal Choroidal Biopsy for Choroidal Melanoma.

Journal Article Retina · April 2017 PURPOSE: We describe two cases of intraoperative 4D microscope–integrated swept source optical coherence tomography (4D MIOCT) guided 27-gauge transvitreal retinochoroidal biopsy for choroidal melanoma. METHODS: Two 68-year-old females with choroidal melan ... Full text Link to item Cite

Review of intraoperative optical coherence tomography: technology and applications [Invited].

Journal Article Biomed Opt Express · March 1, 2017 During microsurgery, en face imaging of the surgical field through the operating microscope limits the surgeon's depth perception and visualization of instruments and sub-surface anatomy. Surgical procedures outside microsurgery, such as breast tumor resec ... Full text Link to item Cite

Four-dimensional Microscope-Integrated Optical Coherence Tomography to Visualize Suture Depth in Strabismus Surgery.

Journal Article J Pediatr Ophthalmol Strabismus · February 14, 2017 The authors report the use of swept-source microscope-integrated optical coherence tomography (SS-MIOCT), capable of live four-dimensional (three-dimensional across time) intraoperative imaging, to directly visualize suture depth during lateral rectus rese ... Full text Link to item Cite

Staying away from the optic nerve: a formula for modifying glaucoma drainage device surgery in pediatric and other small eyes.

Journal Article J AAPOS · February 2017 PURPOSE: To provide guidelines for safe implantation of glaucoma drainage devices (GDDs) in small and pediatric eyes to avoid contact between the optic nerve (ON) and the posterior edge of the GDD plate. METHODS: We developed a formula for calculating limb ... Full text Link to item Cite

Wireless, Web-Based Interactive Control of Optical Coherence Tomography with Mobile Devices.

Journal Article Transl Vis Sci Technol · January 2017 PURPOSE: Optical coherence tomography (OCT) is widely used in ophthalmology clinics and has potential for more general medical settings and remote diagnostics. In anticipation of remote applications, we developed wireless interactive control of an OCT syst ... Full text Open Access Link to item Cite

Four-dimensional microscope- integrated optical coherence tomography to enhance visualization in glaucoma surgeries.

Journal Article Indian J Ophthalmol · January 2017 We report the first use of swept-source microscope-integrated optical coherence tomography (SS-MIOCT) capable of live four-dimensional (4D) (three-dimensional across time) imaging intraoperatively to directly visualize tube shunt placement and trabeculecto ... Full text Link to item Cite

Intraocular Pressure and Big Bubble Diameter in Deep Anterior Lamellar Keratoplasty: An Ex-Vivo Microscope-Integrated OCT With Heads-Up Display Study.

Journal Article Asia Pac J Ophthalmol (Phila) · 2017 PURPOSE: To investigate the relationship between intraocular pressure (IOP) and big bubble (BB) formation in a model of deep anterior lamellar keratoplasty (DALK). DESIGN: Ex-vivo. METHODS: Corneoscleral buttons from human donors were loaded onto an artifi ... Full text Link to item Cite

Retinal thinning in amyotrophic lateral sclerosis patients without ophthalmic disease.

Journal Article PLoS One · 2017 IMPORTANCE: Amyotrophic lateral sclerosis (ALS) is a fatal, rapidly progressive neurodegenerative disease that primarily affects motor neurons. Recently, three causative genes have been implicated in both ALS and glaucoma. However, it is still uncertain wh ... Full text Link to item Cite

Segmentation guided registration of wide field-of-view retinal optical coherence tomography volumes.

Journal Article Biomed Opt Express · December 1, 2016 Patient motion artifacts are often visible in densely sampled or large wide field-of-view (FOV) retinal optical coherence tomography (OCT) volumes. A popular strategy for reducing motion artifacts is to capture two orthogonally oriented volumetric scans. H ... Full text Link to item Cite

Needle Depth and Big-Bubble Success in Deep Anterior Lamellar Keratoplasty: An Ex Vivo Microscope-Integrated OCT Study.

Journal Article Cornea · November 2016 PURPOSE: To examine big-bubble (BB) formation success rates in deep anterior lamellar keratoplasty (DALK) at various corneal depths using real-time guidance from swept-source, microscope-integrated optical coherence tomography (SS-MIOCT). METHODS: The DALK ... Full text Link to item Cite

Wide field of view swept-source optical coherence tomography for peripheral retinal disease.

Journal Article Br J Ophthalmol · October 2016 BACKGROUND/AIMS: To assess peripheral retinal lesions and the posterior pole in single widefield optical coherence tomography (OCT) volumes. METHODS: A wide field of view (FOV) swept-source OCT (WFOV SSOCT) system was developed using a commercial swept-sou ... Full text Link to item Cite

Method for single illumination source combined optical coherence tomography and fluorescence imaging of fluorescently labeled ocular structures in transgenic mice.

Journal Article Exp Eye Res · October 2016 In vivo imaging permits longitudinal study of ocular disease processes in the same animal over time. Two different in vivo optical imaging modalities - optical coherence tomography (OCT) and fluorescence - provide important structural and cellular data res ... Full text Link to item Cite

Eye Bank Graft Preparation for Pre-Descemet's Endothelial Keratoplasty

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography.

Journal Article Sci Rep · August 19, 2016 Minimally-invasive microsurgery has resulted in improved outcomes for patients. However, operating through a microscope limits depth perception and fixes the visual perspective, which result in a steep learning curve to achieve microsurgical proficiency. W ... Full text Open Access Link to item Cite

Posterior Eye Shape Measurement With Retinal OCT Compared to MRI.

Journal Article Invest Ophthalmol Vis Sci · July 1, 2016 PURPOSE: Posterior eye shape assessment by magnetic resonance imaging (MRI) is used to study myopia. We tested the hypothesis that optical coherence tomography (OCT), as an alternative, could measure posterior eye shape similarly to MRI. METHODS: Macular s ... Full text Link to item Cite

Impact of Microscope-Integrated OCT on Ophthalmology Resident Performance of Anterior Segment Surgical Maneuvers in Model Eyes.

Journal Article Invest Ophthalmol Vis Sci · July 1, 2016 PURPOSE: The integration of swept-source optical coherence tomography (SS-OCT) into the operating microscope enables real-time, tissue-level three-dimensional (3D) imaging to aid in ophthalmic microsurgery. In this prospective randomized controlled study, ... Full text Link to item Cite

Novel microscope-integrated stereoscopic heads-up display for intrasurgical optical coherence tomography.

Journal Article Biomed Opt Express · May 1, 2016 Intra-operative optical coherence tomography (OCT) requires a display technology which allows surgeons to visualize OCT data without disrupting surgery. Previous research and commercial intrasurgical OCT systems have integrated heads-up display (HUD) syste ... Full text Link to item Cite

Enhanced volumetric visualization for real time 4D intraoperative ophthalmic swept-source OCT.

Journal Article Biomed Opt Express · May 1, 2016 Current-generation software for rendering volumetric OCT data sets based on ray casting results in volume visualizations with indistinct tissue features and sub-optimal depth perception. Recent developments in hand-held and microscope-integrated intrasurgi ... Full text Link to item Cite

4D microscope-integrated OCT improves accuracy of ophthalmic surgical maneuvers

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2016 Ophthalmic surgeons manipulate micron-scale tissues using stereopsis through an operating microscope and instrument shadowing for depth perception. While ophthalmic microsurgery has benefitted from rapid advances in instrumentation and techniques, the basi ... Full text Cite

Remote, web-based interface control of handheld swept source OCT system for acute care settings

Journal Article Investigative Ophthalmology & Visual Science · 2016 Cite

Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe.

Journal Article Biomed Opt Express · November 1, 2015 We describe the first handheld, swept source optical coherence tomography (SSOCT) system capable of imaging both the anterior and posterior segments of the eye in rapid succession. A single 2D microelectromechanical systems (MEMS) scanner was utilized for ... Full text Link to item Cite

Ultra wide-field swept-source optical coherence tomography for peripheral eye disease

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Complete 360° circumferential gonioscopic optical coherence tomography imaging of the iridocorneal angle.

Journal Article Biomed Opt Express · April 1, 2015 Clinically, gonioscopy is used to provide en face views of the ocular angle. The angle has been imaged with optical coherence tomography (OCT) through the corneoscleral limbus but is currently unable to image the angle from within the ocular anterior chamb ... Full text Link to item Cite

Intraoperative retinal optical coherence tomography

Chapter · January 1, 2015 In this chapter, the emerging applications for OCT in real-time, intraoperative diagnostic imaging and visualization of surgical maneuvers is reviewed, focusing on OCT guidance and evaluation of ophthalmic microsurgery. Three different approaches under dev ... Full text Cite

Textural interface opacity after Descemet-stripping automated endothelial keratoplasty.

Journal Article J Cataract Refract Surg · September 2014 PURPOSE: To describe cases of interface haze, also known as textural interface opacity, after Descemet-stripping automated endothelial keratoplasty (DSAEK). SETTING: Department of Cornea, External Disease, and Refractive Surgery Service, Duke Eye Center, D ... Full text Link to item Cite

Risk factors for exposure of glaucoma drainage devices: a retrospective observational study.

Journal Article BMJ Open · May 2, 2014 OBJECTIVES: The purpose of this study was to identify risk factors for exposure of glaucoma drainage devices (GDD). SETTING: This retrospective, observational study was conducted in the eye clinic of an academic medical centre. PARTICIPANTS: Participants i ... Full text Link to item Cite

Spectral Domain Optical Coherence Tomography Imaging of Ocular Surface Lesions

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Single Source Fluorescence Imaging/Blue Optical Coherence Tomography in a GFP Mouse Model

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Imaging amyotrophic lateral sclerosis (ALS) neurodegeneration through the eye

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Complete 360° circumferential SSOCT gonioscopy of the iridocorneal angle

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 The ocular iridocorneal angle is generally an optically inaccessible area when viewed directly through the cornea due to the high angle of incidence required and the large index of refraction difference between air and cornea (nair = 1.000 and ncornea = 1. ... Full text Cite

Quantifying the cornea's optical performance

Other Optics and Photonics News · January 1, 2014 Full text Cite

Fast acquisition and reconstruction of optical coherence tomography images via sparse representation.

Journal Article IEEE Trans Med Imaging · November 2013 In this paper, we present a novel technique, based on compressive sensing principles, for reconstruction and enhancement of multi-dimensional image data. Our method is a major improvement and generalization of the multi-scale sparsity based tomographic den ... Full text Link to item Cite

Quantitative single and multi-surface clinical corneal topography utilizing optical coherence tomography.

Journal Article Opt Lett · April 15, 2013 Successful surgical treatment of ocular astigmatism requires accurate characterization of both magnitude and axis of the astigmatism. Keratometry and topography are clinically widely used for this measurement; however, their analysis is limited to the ante ... Full text Link to item Cite

Distributed scan SDOCT improves post refractive surgery corneal biometry

Conference Digital Holography and Three-Dimensional Imaging, DH 2012 · December 1, 2012 We report on a preliminary study comparing corneal refractive power acquired using distributed scanning OCT (DSOCT) to corneal topography and Scheimpflug photography in normal subjects both before and after refractive surgery. ... Cite

Distributed scanning volumetric SDOCT for motion corrected corneal biometry.

Journal Article Biomed Opt Express · September 1, 2012 We present a method, termed distributed scanning OCT (DSOCT), which reduces the effects of patient motion on corneal biometry utilizing current-generation clinically available spectral domain optical coherence tomography (SDOCT) systems. We first performed ... Full text Link to item Cite

Corneal biometry from volumetric SDOCT and comparison with existing clinical modalities.

Journal Article Biomed Opt Express · June 1, 2012 We present a comparison of corneal biometric values from dense volumetric spectral domain optical coherence tomography (SDOCT) scans to reference values in both phantoms and clinical subjects. We also present a new optically based "keratometric equivalent ... Full text Link to item Cite

Simultaneous swept source optical coherence tomography of the anterior segment and retina using coherence revival.

Journal Article Opt Lett · June 1, 2012 We report on an implementation of coherence revival-based heterodyne swept source optical coherence tomography that is capable of simultaneously imaging the anterior and posterior eye. A polarization-encoded sample arm was used to efficiently focus orthogo ... Full text Link to item Cite

Robust automatic segmentation of corneal layer boundaries in SDOCT images using graph theory and dynamic programming.

Journal Article Biomed Opt Express · June 1, 2011 Segmentation of anatomical structures in corneal images is crucial for the diagnosis and study of anterior segment diseases. However, manual segmentation is a time-consuming and subjective process. This paper presents an automatic approach for segmenting c ... Full text Link to item Cite

3D refraction correction and extraction of clinical parameters from spectral domain optical coherence tomography of the cornea.

Journal Article Opt Express · April 26, 2010 Capable of three-dimensional imaging of the cornea with micrometer-scale resolution, spectral domain-optical coherence tomography (SDOCT) offers potential advantages over Placido ring and Scheimpflug photography based systems for accurate extraction of qua ... Full text Open Access Link to item Cite

SDOCT Measurement of Corneal Power and Comparision With Standard Techniques

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2010 Link to item Cite

Motion Artifact Reduced SDOCT of the Anterior Segment

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2010 Link to item Cite

Corneal wound architecture and integrity after torsional and mixed phacoemulsification: evaluation of standard and microincisional coaxial techniques.

Journal Article Ophthalmic Surg Lasers Imaging · 2010 BACKGROUND AND OBJECTIVE: To compare the effects of torsional and mixed ultrasound on clear corneal incision architecture, wound integrity, and apposition using standard (2.75 mm) and microincisional (2.2 mm) coaxial phacoemulsification. SUBJECTS AND METHO ... Full text Link to item Cite

Air bubble-associated endothelial trauma in descemet stripping automated endothelial keratoplasty.

Journal Article Am J Ophthalmol · August 2009 PURPOSE: To evaluate endothelial cell trauma by anterior chamber (AC) air bubbles in Descemet stripping automated endothelial keratoplasty (DSAEK). DESIGN: Laboratory investigation. METHODS: Twelve human donor corneas (6 pairs) were sectioned using an auto ... Full text Link to item Cite

Refractive change after descemet stripping automated endothelial keratoplasty surgery and its correlation with graft thickness and diameter.

Journal Article Cornea · January 2009 PURPOSE: The purpose of this study was to evaluate the refractive change after Descemet stripping automated endothelial keratoplasty (DSAEK) surgery and its correlation with graft thickness and diameter. METHODS: We retrospectively analyzed the refractive ... Full text Link to item Cite

Novel delivery method to reduce endothelial injury in descemet stripping automated endothelial keratoplasty.

Journal Article Am J Ophthalmol · January 2008 PURPOSE: To present a novel technique to deliver the endothelial graft in small incision Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) and to compare graft trauma between forceps delivery and the novel technique. DESIGN: Laboratory investig ... Full text Link to item Cite

Distribution of refractive error in healthy infants.

Journal Article J AAPOS · June 2003 PURPOSE: Few data exist regarding the upper limits of refractive error distributions in healthy infants; the data that do exist are biased because they were selected from the records of pediatric ophthalmology practices. We sought to obtain these data to v ... Full text Link to item Cite

Advances in Whole-Eye Optical Coherence Tomography Imaging.

Journal Article Asia Pac J Ophthalmol (Phila) Contemporary anterior segment and retinal optical coherence tomography (OCT) systems only image their particular designated region of the eye and cannot image both areas of the eye at the same time. This separation is due to the differences in optical syst ... Full text Link to item Cite