Scholars@Duke
Bradley Henry Collins

Bradley Henry Collins

Associate Professor of Surgery
Surgery, Abdominal Transplant Surgery
colli005@mc.duke.edu
Box 3512 Med Ctr, Durham, NC 27710
Hanes House, Trent Drive, Durham, NC 27710

Selected Publications

Late surgical site infections among solid organ transplant recipients: an unrecognized clinical entity.

Journal Article Infect Control Hosp Epidemiol · May 24, 2024 This study identified 26 late invasive primary surgical site infection (IP-SSI) within 4-12 months of transplantation among 2073 SOT recipients at Duke University Hospital over the period 2015-2019. Thoracic organ transplants accounted for 25 late IP-SSI. ... Full text Link to item Cite

Improving Health Equity in Living Donor Kidney Transplant: Application of an Implementation Science Framework.

Journal Article Transplant Proc · 2024 BACKGROUND: Interventions to improve racial equity in access to living donor kidney transplants (LDKT) have focused primarily on patients, ignoring the contributions of clinicians, transplant centers, and health system factors. Obtaining access to LDKT is ... Full text Link to item Cite

Epidemiology of surgical site infections after solid organ transplants in the period 2015-2019: A single-center retrospective cohort study.

Journal Article Am J Transplant · December 2022 Surgical site infections (SSI) are severe complications of solid organ transplant (SOT). This retrospective study assessed the epidemiology of and outcomes associated with invasive primary SSI (IP-SSI) occurring within 3 months of transplantation in adult ... Full text Open Access Link to item Cite

A Historical Cohort in Kidney Transplantation: 55-Year Follow-Up of 72 HLA-Identical, Donor-Recipient Pairs.

Journal Article J Clin Med · November 24, 2021 The impact of HLA matching on graft survival has been well characterized in renal transplantation, with a higher degree of matching associated with superior graft survival. Additionally, living donor grafts are known to confer superior survival compared to ... Full text Link to item Cite

Definition and Analysis of Textbook Outcome: A Novel Quality Measure in Kidney Transplantation.

Journal Article World J Surg · May 2021 BACKGROUND: "Textbook outcome" (TO) is a novel composite quality measure that encompasses multiple postoperative endpoints, representing the ideal "textbook" hospitalization for complex surgical procedures. We defined TO for kidney transplantation using a ... Full text Link to item Cite

Coagulation, inflammation, and CD46 transgene expression in neonatal porcine islet xenotransplantation.

Journal Article Xenotransplantation · May 2021 BACKGROUND: Thrombosis is a known consequence of intraportal islet transplantation, particularly for xenogeneic islets. To define the origins of thrombosis after islet xenotransplantation and relate it to early inflammation, we examined porcine islets tran ... Full text Link to item Cite

The Legacy of Joseph A. Moylan, M.D.: "It's About Everyone Else".

Journal Article Ann Surg Open · March 2021 The history of modern American surgery is marked by larger-than-life pioneers who have made transformative contributions to our field. These extraordinary individuals have been known primarily for their technical and clinical mastery, development of novel ... Full text Link to item Cite

Preoperative carfilzomib and lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model.

Journal Article Kidney Int · January 2021 Sensitized patients are difficult to transplant due to pre-formed anti-donor immunity. We have previously reported successful desensitization using carfilzomib and belatacept in a non-human primate (NHP) model. Here we evaluated selective blockade of the c ... Full text Link to item Cite

Kidney transplant in the COVID era: Cautious optimism and continued vigilance.

Journal Article Am J Transplant · November 2020 The authors comment on the usefulness of a new model to advise centers on risks versus benefits of kidney transplantation during the COVID epidemic. See page 2997 for Massie et al's article. ... Full text Link to item Cite

Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients.

Journal Article J Am Soc Nephrol · December 2019 BACKGROUND: Patients with broad HLA sensitization have poor access to donor organs, high mortality while waiting for kidney transplant, and inferior graft survival. Although desensitization strategies permit transplantation via lowering of donor-specific a ... Full text Link to item Cite

The role of human CD46 in early xenoislet engraftment in a dual transplant model.

Journal Article Xenotransplantation · November 2019 BACKGROUND: Membrane cofactor protein CD46 attenuates the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46 have been shown to resist hyperacute rejection. However, the incremental value ... Full text Link to item Cite

Evaluation and Active Treatment versus Active Surveillance of Localized Prostate Cancer in Renal Transplant Patients in the Era of Low and Very Low Risk Prostate Cancer.

Journal Article J Urol · September 2019 PURPOSE: Current trends in renal transplantation, such as improved allograft/recipient survival and expanded organ transplantation eligibility criteria in older recipients, are concomitant with increasingly detected low risk prostate cancer in candidates f ... Full text Link to item Cite

Secondary lymphoid tissue and costimulation-blockade resistant rejection: A nonhuman primate renal transplant study.

Journal Article Am J Transplant · August 2019 Naïve T cell activation requires antigen presentation combined with costimulation through CD28, both of which optimally occur in secondary lymphoid tissues such as lymph nodes and the spleen. Belatacept impairs CD28 costimulation by binding its ligands, CD ... Full text Link to item Cite

Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use.

Journal Article J Am Soc Nephrol · July 2019 BACKGROUND: Donor-specific antibodies are associated with increased risk of antibody-mediated rejection and decreased allograft survival. Therefore, reducing the risk of these antibodies remains a clinical need in transplantation. Plasma cells are a logica ... Full text Link to item Cite

Medical evaluation of the living donor

Chapter · January 1, 2019 Living donor kidney transplants constitute between 10% and 50% of annual kidney transplant volume worldwide. This chapter presents the history of living donation through the modern-day approach to living donation, with a focus on evolving paradigms of what ... Full text Cite

Early barriers to neonatal porcine islet engraftment in a dual transplant model.

Journal Article Am J Transplant · April 2018 Porcine islet xenografts have the potential to provide an inexhaustible source of islets for β cell replacement. Proof-of-concept has been established in nonhuman primates. However, significant barriers to xenoislet transplantation remain, including the po ... Full text Link to item Cite

Fatal SV40-associated pneumonia and nephropathy following renal allotransplantation in rhesus macaque.

Journal Article J Med Primatol · February 2018 Recrudescence of latent and dormant viruses may lead to overwhelming viremia in immunosuppressed hosts. In immunocompromised hosts, Simian virus 40 (SV40) reactivation is known to cause nephritis and demyelinating central nervous system disease. Here, we r ... Full text Link to item Cite

Selective Targeting of High-Affinity LFA-1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model.

Journal Article Am J Transplant · May 2017 Costimulation blockade (CoB) via belatacept is a lower-morbidity alternative to calcineurin inhibitor (CNI)-based immunosuppression. However, it has higher rates of early acute rejection. These early rejections are mediated in part by memory T cells, which ... Full text Link to item Cite

Application of a Novel CT-Based Iliac Artery Calcification Scoring System for Predicting Renal Transplant Outcomes.

Journal Article AJR Am J Roentgenol · February 2016 OBJECTIVE: The objective of our study was to assess whether the degree and distribution of iliac artery calcifications as determined by a CT-based calcium scoring system correlates with outcomes after renal transplant. MATERIALS AND METHODS: A retrospectiv ... Full text Link to item Cite

Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction.

Journal Article Am J Transplant · May 2015 Islet xenotransplantation is a potential treatment for diabetes without the limitations of tissue availability. Although successful experimentally, early islet loss remains substantial and attributed to an instant blood-mediated inflammatory reaction (IBMI ... Full text Link to item Cite

Repletion of S-nitrosohemoglobin improves organ function and physiological status in swine after brain death.

Journal Article Ann Surg · May 2013 OBJECTIVE: To determine if reduction in nitric oxide bioactivity contributes to the physiological instability that occurs after brain death and, if so, to also determine in this setting whether administration of a renitrosylating agent could improve system ... Full text Link to item Cite

Posterior reversible encephalopathy syndrome independently associated with tacrolimus and sirolimus after multivisceral transplantation.

Journal Article Am J Transplant · March 2013 Posterior reversible encephalopathy syndrome (PRES) is a small vessel microangiopathy of the cerebral vasculature that occurs in 0.5-5% of solid organ transplant recipients, most commonly associated with tacrolimus (Tac). Clinical manifestations include hy ... Full text Link to item Cite

Liver transplantation

Chapter · January 1, 2013 Full text Cite

Use of vascularized posterior rectus sheath allograft in pediatric multivisceral transplantation--report of two cases.

Journal Article Am J Transplant · August 2012 Restoring abdominal wall cover and contour in children undergoing bowel and multivisceral transplantation is often challenging due to discrepancy in size between donor and recipient, poor musculature related to birth defects and loss of abdominal wall inte ... Full text Link to item Cite

Fatal Apophysomyces elegans infection transmitted by deceased donor renal allografts.

Journal Article Am J Transplant · September 2010 Two patients developed renal mucormycosis following transplantation of kidneys from the same donor, a near-drowning victim in a motor vehicle crash. Genotypically, indistinguishable strains of Apophysomyces elegans were recovered from both recipients. We i ... Full text Link to item Cite

Sublingual Tacrolimus after High Risk Kidney Transplant

Conference AMERICAN JOURNAL OF TRANSPLANTATION · April 1, 2010 Link to item Cite

Temporal trends in liver transplant centre volume in the USA.

Journal Article HPB (Oxford) · August 2009 BACKGROUND: Although prior studies have suggested an inverse association between liver transplant centre volume and postoperative patient mortality, more recent analyses have failed to confirm this association. To date, all studies of the relationship betw ... Full text Link to item Cite

Humoral Rejection after Liver Transplantation.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · January 1, 2009 Link to item Cite

Relationship between provider volume and outcomes for orthotopic liver transplantation.

Journal Article J Gastrointest Surg · September 2008 INTRODUCTION: Recent data suggests that the previously demonstrable relationship between hospital volume and outcomes for liver transplant procedures may no longer exist. Furthermore, to our knowledge, no study has been published examining whether individu ... Full text Link to item Cite

Chronic aspiration shifts the immune response from Th1 to Th2 in a murine model of asthma.

Journal Article Eur J Clin Invest · August 2008 BACKGROUND: Chronic aspiration associated with gastro oesophageal reflux disease (GERD) is thought to play a substantial role in the development of asthma, the incidence of which is dramatically increasing in industrially developed countries. The majority ... Full text Link to item Cite

Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants.

Journal Article Am J Transplant · August 2008 Long-term survival of a pulmonary allograft is currently hampered by obliterative bronchiolitis (OB), a form of chronic rejection that is unique to lung transplantation. While tracheobronchial aspiration from gastroesophageal reflux disease (GERD) has clin ... Full text Link to item Cite

Supply and demand for liver transplant surgery: are we training enough surgeons?

Journal Article HPB (Oxford) · 2008 The purpose of our study is to determine whether the current level of transplant fellow training is sufficient to meet the future demand for liver transplantation in the United States. Historical data from the Nationwide Inpatient Samples (NIS) for the yea ... Full text Link to item Cite

Intra-operative aprotinin in liver transplant and renal dysfunction.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 1, 2007 Link to item Cite

Rejection

Chapter · January 1, 2007 Full text Cite

Temporal trends in early clinical outcomes and health care resource utilization for liver transplantation in the United States.

Journal Article J Gastrointest Surg · January 2007 INTRODUCTION: Procedures such as liver transplantation, which entail large costs while benefiting only a small percentage of the population, are being increasingly scrutinized by third-party payors. The purpose of our study was to conduct a longitudinal an ... Full text Link to item Cite

Obesity predicts increased overall complications following pancreas transplantation.

Journal Article Transplant Proc · October 2005 PURPOSE: We sought to evaluate the role of recipient body mass index (BMI) on postoperative complications in patients receiving pancreas transplants. METHODS: A single-institution retrospective study of 145 consecutive patients undergoing either simultaneo ... Full text Link to item Cite

Half-life analysis of pancreas and kidney transplants.

Journal Article Transplantation · July 27, 2005 Although graft and patient survival data are available for pancreas and kidney transplants, they are rarely reported in terms of half-life. Our aim was to determine whether a more relevant measure of outcome is patient and allograft half-life. Using the da ... Full text Link to item Cite

Gastrointestinal hemorrhage due to complicated gastroduodenal ulcer disease in liver transplant patients taking sirolimus.

Journal Article Clin Transplant · April 2005 Sirolimus is emerging as a popular immunosuppressive agent for patients undergoing solid organ and pancreatic cell transplantation. Here, we report the clinical courses of three patients receiving sirolimus who developed aggressive gastroduodenal ulcer dis ... Full text Link to item Cite

The current status of living donor liver transplantation.

Journal Article Curr Probl Surg · March 2005 In response to the critical organ shortage, transplant professionals have utilized living donors in an attempt to decrease the mortality rate associated with waiting on the liver transplant list. Although the surgical techniques were first utilized clinica ... Full text Link to item Cite

Acute kidney transplant failure following transurethral bladder polyp fulguration.

Journal Article J Natl Med Assoc · March 2005 Ureteral obstruction and anastomotic leak represent the most common urologic complications of kidney transplantation. Delay in diagnosis or treatment can lead to allograft loss. Obstruction of the ureter occurs in 2% of kidney transplant recipients. Althou ... Link to item Cite

Effect of alginate composition and purity on alginate microspheres

Journal Article Journal of Microencapsulation · December 2004 Full text Cite

Intraoperative fluid management during orthotopic liver transplantation.

Journal Article J Cardiothorac Vasc Anesth · August 2004 OBJECTIVE: To assess clinical safety of a low central venous pressure (CVP) fluid management strategy in patients undergoing liver transplantation. DESIGN: Retrospective record review comparing 2 transplant centers, one using the low CVP method and the oth ... Full text Link to item Cite

Polyvinyl Pyrrolidone: A Novel Cryoprotectant in Islet Cell Cryopreservation.

Journal Article Cell Transplant · April 2004 The present study was performed on the basis of the hypothesis that the low molecular weight (MW) compounds, DMSO and glycerol, permeate the cell and interact hydrophobically with intracellular proteins, thereby perturbing the cytoskeletal architecture of ... Full text Link to item Cite

Microbial biofilms in the gut: visualization by electron microscopy and by acridine orange staining.

Journal Article Ultrastruct Pathol · 2004 The expression of colonization factors by gut bacteria, the growth rate of gut bacteria, and the rate of plasmid exchange by gut bacteria indicate that biofilms are a normal component of bacterial growth in the large bowel. Further, in vitro experiments de ... Link to item Cite

The management of end stage renal disease in the recipients of extrarenal transplants

Conference AMERICAN JOURNAL OF TRANSPLANTATION · January 1, 2004 Link to item Cite

Beneficial effect of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection.

Journal Article Transplantation · May 15, 2003 BACKGROUND: Acute humoral rejection (AHR) has been associated with enhanced graft loss. Our study compared the renal allograft survival of patients with AHR treated with plasmapheresis (PP) and intravenous immunoglobulin (IVIG) with allograft survival in p ... Full text Link to item Cite

De-novo cholangiocarcinoma in the setting of recurrent primary sclerosing cholangitis following liver transplant.

Journal Article Am J Transplant · May 2003 Orthotopic liver transplantation is the only definitive therapeutic option in patients with primary sclerosing cholangitis (PSC) and end-stage liver disease. However, PSC recurs in up to 20% of patients transplanted for this indication. To date, no patient ... Full text Link to item Cite

Emergencies after liver transplantation.

Journal Article Semin Gastrointest Dis · April 2003 Liver transplantation has become the procedure of choice for a wide variety of patients with end-stage liver disease. Perioperative morbidity and mortality have decreased dramatically over the past two decades, and superior graft and patient survival rates ... Link to item Cite

Porcine islets as an alternative to human islets for transplantation.

Journal Article J Investig Med · November 2001 Featured Publication Full text Link to item Cite

A reliable method for isolation of viable porcine islet cells.

Journal Article Arch Surg · March 2001 Featured Publication HYPOTHESIS: Mechanical injury and oxidative stress caused by reoxygenation of isolated porcine islet cells result in their unresponsiveness to glucose stimulation. DESIGN: Adult pigs (weighing 25-30 kg) were anesthetized, and following intra-arterial infus ... Full text Link to item Cite

Islet cell transplantation for the treatment of diabetes mellitus.

Journal Article Expert Opin Biol Ther · January 2001 Featured Publication Diabetes mellitus is estimated to affect at least 16 million individuals in the United States and 135 million persons worldwide. It is a significant cause of morbidity and early mortality. The related expenses are astronomical with at least 15% of healthca ... Full text Link to item Cite

Long-term results of liver transplantation in older patients 60 years of age and older.

Journal Article Transplantation · September 15, 2000 BACKGROUND: Advances in perioperative care and immunosuppression have enabled clinicians to broaden the indications for organ transplantation. Advanced age is no longer considered a contraindication to transplantation at most centers. Although short-term s ... Full text Link to item Cite

Simultaneous pancreas-kidney transplantation reduces excess mortality in type 1 diabetic patients with end-stage renal disease.

Journal Article Kidney Int · May 2000 BACKGROUND: Diabetic renal disease continues to be the most significant cause of end-stage renal disease (ESRD) in the United States. Renal transplantation improves diabetic ESRD patient survival; however, the diabetic state remains associated with poor pa ... Full text Link to item Cite

Microcapsule stabilization with sodium sulfate pretreatment.

Journal Article TRANSPLANTATION · April 27, 2000 Link to item Cite

Using renal transplantation to evaluate a simple approach for predicting the impact of end-stage renal disease therapies on patient survival: observed/expected life span.

Journal Article Am J Kidney Dis · April 2000 The effectiveness of therapy for a chronic disease can be assessed by evaluating the length of time that a patient survives after receiving treatment. We used a novel means for measuring the effectiveness of renal replacement therapy for patients with end- ... Full text Link to item Cite

Bile acids in xenogeneic ex-vivo liver perfusion: function of xenoperfused livers and compatibility with human bile salts and porcine livers.

Journal Article Transplantation · January 27, 2000 BACKGROUND: In recent years, hepatic support systems using xenogeneic cells have been developed to support patients in fulminant hepatic failure. The extent to which xenogeneic hepatocytes metabolize and excrete human organic anions is unclear. In these st ... Full text Link to item Cite

Peripheral vascular disease and renal transplant artery stenosis: a reappraisal of transplant renovascular disease.

Journal Article Clin Transplant · August 1999 BACKGROUND: Renal transplant artery stenosis (RTAS) continues to be a problematic, but potentially correctable, cause of post-transplant hypertension and graft dysfunction. Older transplant recipients, prone to peripheral vascular disease (PVD), may have p ... Full text Link to item Cite

The impact of hypoalbuminemia in kidney-pancreas transplant recipients.

Journal Article Transplantation · July 15, 1999 BACKGROUND: Hypoalbuminemia is associated with poorer outcomes in renal transplantation. Diabetes can compound hypoalbuminemia's detrimental effects. Kidney-pancreas transplantation alters the diabetic milieu; yet, some patients continue to be hypoalbumine ... Full text Link to item Cite

Living unrelated renal donation: the University of Wisconsin experience.

Journal Article Surgery · October 1998 BACKGROUND: Living unrelated renal donation (LURD) has the potential to reduce the current waiting list significantly for kidney transplantation. The purpose of this study was to examine the long-term results of 150 LURDs performed at our center during a 1 ... Full text Link to item Cite

Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts.

Journal Article Transplantation · March 27, 1997 A single bolus of soluble complement (C) receptor type 1 (sCR1, TP-10) has been shown to delay hyperacute rejection (HAR) of porcine cardiac xenografts (Xgs) by primate recipients. In these recipients, C activity slowly returned and C deposition was noted ... Full text Link to item Cite

Advances in pancreas transplantation: the University of Wisconsin experience.

Journal Article Clin Transpl · 1997 The data show that with careful surgical technique, modern immunosuppression with MMF and FK506, and pancreatic allograft biopsy, it should be possible to achieve: 1) a low rate of technical complications, 2) improved long-term graft survival, particularly ... Link to item Cite

Quality of life after treatment for pancreatitis.

Journal Article Ann Surg · June 1996 OBJECTIVE: The authors evaluated the morbidity, mortality, and quality of life after pancreatic debridement for necrosis and compared these values to those for quality of life after elective medical and surgical management for chronic pancreatitis. SUMMARY ... Full text Link to item Cite

Immunoglobulin prevents complement-mediated hyperacute rejection in swine-to-primate xenotransplantation.

Journal Article J Clin Invest · November 1995 Immunoglobulins regulate the complement system by activating complement on foreign surfaces and diverting reactive complement proteins away from autologous cell surfaces. Based on this model, we explored the ability of Ig to balance complement activation v ... Full text Link to item Cite

The humoral immune response in humans following cross-perfusion of porcine organs.

Journal Article Transplantation · October 27, 1995 A major question in xenotransplantation is the nature of the humoral response that would occur following the transplantation of a xenogeneic organ into an immunosuppressed recipient as such a response could mediate delayed types of injury to the graft. To ... Link to item Cite

Variation in the level of xenoantigen expression in porcine organs.

Journal Article Transplantation · June 15, 1995 Hyperacute rejection of vascularized porcine to primate xenografts is initiated by the binding of xenoreactive natural antibodies to donor endothelium. We tested the hypothesis that the level of xenoantigen expression varies in the population of potential ... Link to item Cite

Cardiac xenografts between primate species provide evidence for the importance of the alpha-galactosyl determinant in hyperacute rejection.

Journal Article J Immunol · May 15, 1995 Transplants performed between phylogenetically disparate species are subject to hyperacute rejection initiated by binding of xenoreactive natural Abs to endothelium in the donor organ. Binding of these Abs activates complement, leading to tissue injury and ... Link to item Cite

QUALITY-OF-LIFE AFTER PANCREATIC DEBRIDEMENT

Conference GASTROENTEROLOGY · 1995 Full text Cite

Mechanisms of injury in porcine livers perfused with blood of patients with fulminant hepatic failure.

Journal Article Transplantation · December 15, 1994 Hyperacute rejection of renal and cardiac xenografts is initiated by the reaction of recipient natural antibodies and complement with endothelial cell antigens of the donor organ. The liver is thought to be less susceptible to this form of rejection; howev ... Link to item Cite

The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts.

Journal Article Transplantation · February 1994 The use of xenografts (Xgs) from distantly related species to relieve the increasing shortage of organs for clinical transplantation is prevented by the occurrence of hyperacute rejection (HAR). This process, in which C activation plays a central role, can ... Full text Link to item Cite

Characterization of porcine endothelial cell determinants recognized by human natural antibodies

Journal Article Xenotransplantation · January 1, 1994 Abstract: Organs transplanted from pigs to primates are subject to hyperacute rejection. This immunologic reaction is initiated by the recipient's natural antibodies that bind to endothelial cell antigens of the organ, resulting in the activation of the co ... Full text Cite