Daniel Todd Laskowitz

Journal Article J Clin Med · January 16, 2025 Background/Objectives: Traumatic brain injury (TBI) is a complex condition and a leading cause of injury-related disability and death, with significant impacts on patient outcomes. Extracranial organ involvement plays a critical role in the outcome of pati ... Full text Link to item Cite

Clinical development of the GluN2B-selective NMDA receptor inhibitor NP10679 for the treatment of neurologic deficit after subarachnoid hemorrhage.

Journal Article J Pharmacol Exp Ther · January 2025 Aneurysmal subarachnoid hemorrhage (SAH) may be associated with cerebral vasospasm, which can lead to delayed cerebral ischemia, infarction, and worsened functional outcomes. The delayed nature of cerebral ischemia secondary to SAH-related vasculopathy pre ... Full text Link to item Cite

Clinical Development of the GluN2B-selective NMDA Receptor Inhibitor NP10679 for the Treatment of Neurologic Deficit after Subarachnoid Hemorrhage.

Journal Article J Pharmacol Exp Ther · October 23, 2024 Aneurysmal subarachnoid hemorrhage (aSAH) may be associated with cerebral vasospasm, which can lead to delayed cerebral ischemia, infarction, and worsened functional outcomes. The delayed nature of cerebral ischemia secondary to SAH-related vasculopathy pr ... Full text Link to item Cite

Early Beta-Blocker Utilization in Critically Ill Patients With Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study.

Journal Article J Intensive Care Med · September 2024 BACKGROUND: There is limited evidence that beta-blockers may provide benefit for patients with moderate-severe traumatic brain injury (TBI) during the acute injury period. Larger studies on utilization patterns and impact on outcomes in clinical practice a ... Full text Link to item Cite

Association of Early Dexmedetomidine Utilization With Clinical Outcomes After Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study.

Journal Article Anesth Analg · August 1, 2024 BACKGROUND: Traumatic brain injury (TBI) is an expensive and common public health problem. Management of TBI oftentimes includes sedation to facilitate mechanical ventilation (MV) for airway protection. Dexmedetomidine has emerged as a potential candidate ... Full text Link to item Cite

Association of early dexmedetomidine exposure with brain injury biomarker levels following moderate - Severe traumatic brain injury: A TRACK-TBI study.

Journal Article J Clin Neurosci · August 2024 BACKGROUND: Traumatic brain injury (TBI) triggers autonomic dysfunction and inflammatory response that can result in secondary brain injuries. Dexmedetomidine is an alpha-2 agonist that may modulate autonomic function and inflammation and has been increasi ... Full text Link to item Cite

RECOVER-NEURO: study protocol for a multi-center, multi-arm, phase 2, randomized, active comparator trial evaluating three interventions for cognitive dysfunction in post-acute sequelae of SARS-CoV-2 infection (PASC).

Journal Article Trials · May 17, 2024 BACKGROUND: Post-acute sequelae of SARS-CoV-2 infection (PASC) symptoms have broad impact, and may affect individuals regardless of COVID-19 severity, socioeconomic status, race, ethnicity, or age. A prominent PASC symptom is cognitive dysfunction, colloqu ... Full text Open Access Link to item Cite

Effects of Amyloid Beta (Aβ) Oligomers on Blood-Brain Barrier Using a 3D Microfluidic Vasculature-on-a-Chip Model.

Journal Article Applied sciences (Basel, Switzerland) · May 2024 The disruption of the blood-brain barrier (BBB) in Alzheimer's Disease (AD) is largely influenced by amyloid beta (Aβ). In this study, we developed a high-throughput microfluidic BBB model devoid of a physical membrane, featuring endothelial cells interact ... Full text Cite

Association of Early Dexmedetomidine Utilization With Clinical and Functional Outcomes Following Moderate-Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study.

Journal Article Crit Care Med · April 1, 2024 OBJECTIVE: To examine early sedation patterns, as well as the association of dexmedetomidine exposure, with clinical and functional outcomes among mechanically ventilated patients with moderate-severe traumatic brain injury (msTBI). DESIGN: Retrospective c ... Full text Link to item Cite

Optimization of a translational murine model of closed-head traumatic brain injury.

Journal Article Neurol Res · April 2024 Traumatic brain injury (TBI) from closed-head trauma is a leading cause of disability, with limited effective interventions. Many TBI models impact brain parenchyma directly, and are limited by the fact that these forces do not recapitulate clinically rele ... Full text Link to item Cite

Experience with a hybrid recruitment approach of patient-facing web portal screening and subsequent phone and medical record review for a neurosurgical intervention trial for chronic ischemic stroke disability (PISCES III).

Journal Article Trials · February 28, 2024 BACKGROUND: Recruitment of participants is the greatest risk to completion of most clinical trials, with 20-40% of trials failing to reach the targeted enrollment. This is particularly true of trials of central nervous system (CNS) therapies such as interv ... Full text Link to item Cite

A Randomized, Placebo-Controlled, Phase II Trial of Intravenous Allogeneic Non-HLA Matched, Unrelated Donor, Cord Blood Infusion for Ischemic Stroke.

Journal Article Stem Cells Transl Med · February 14, 2024 Stroke remains a leading cause of death and disability in the US, and time-limited reperfusion strategies remain the only approved treatment options. To address this unmet clinical need, we conducted a phase II randomized clinical trial to determine whethe ... Full text Open Access Link to item Cite

A study protocol for risk stratification in children with concussion (RSiCC): Theoretical framework, design, and methods.

Journal Article PLoS One · 2024 Research shows that one in five children will experience a concussion by age 16. Compared to adults, children experience longer and more severe postconcussive symptoms (PCS), with severity and duration varying considerably among children and complicating m ... Full text Link to item Cite

Data analysis protocol for early autonomic dysfunction characterization after severe traumatic brain injury.

Journal Article Front Neurol · 2024 BACKGROUND: Traumatic brain injury (TBI) disrupts normal brain tissue and functions, leading to high mortality and disability. Severe TBI (sTBI) causes prolonged cognitive, functional, and multi-organ dysfunction. Dysfunction of the autonomic nervous syste ... Full text Link to item Cite

ApoE Mimetic Peptides as Therapy for Traumatic Brain Injury.

Journal Article Neurotherapeutics · October 2023 The lack of targeted therapies for traumatic brain injury (TBI) remains a compelling clinical unmet need. Although knowledge of the pathophysiologic cascades involved in TBI has expanded rapidly, the development of novel pharmacological therapies has remai ... Full text Link to item Cite

Association of Early Beta-Blocker Exposure and Functional Outcomes in Critically Ill Patients With Moderate to Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study.

Journal Article Critical care explorations · September 2023 ObjectivesWe aimed to 1) describe patterns of beta-blocker utilization among critically ill patients following moderate-severe traumatic brain injury (TBI) and 2) examine the association of early beta-blocker exposure with functional and clinical ... Full text Open Access Cite

Association of Brain Injury Biomarkers and Circulatory Shock Following Moderate-Severe Traumatic Brain Injury: A TRACK-TBI Study.

Journal Article J Neurosurg Anesthesiol · July 1, 2023 INTRODUCTION: Early circulatory shock following traumatic brain injury (TBI) is a multifactorial process; however, the impact of brain injury biomarkers on the risk of shock has not been evaluated. We examined the association between neuronal injury biomar ... Full text Open Access Link to item Cite

Phase 1 Clinical Results for NP10679, a pH-sensitive GluN2B-selective N-methyl-d-aspartate Receptor Inhibitor.

Journal Article Clinical pharmacology in drug development · July 2023 NP10679 is a context-dependent and subunit-selective negative allosteric modulator of N-methyl-d-aspartate (NMDA) receptors. It is a more potent inhibitor of GluN2B-containing NMDA receptors at the acidic levels of extracellular pH (eg, 6.9) found in the p ... Full text Cite

Utilization and Outcomes of Extracorporeal Membrane Oxygenation Following Traumatic Brain Injury in the United States.

Journal Article J Intensive Care Med · May 2023 Objectives: Describe contemporary ECMO utilization patterns among patients with traumatic brain injury (TBI) and examine clinical outcomes among TBI patients requiring ECMO. Design: Retrospective cohort study. Setting: Premier Healthcare Database (PHD) bet ... Full text Link to item Cite

Complications of Intravenous Tenecteplase Versus Alteplase for the Treatment of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.

Journal Article Stroke · May 2023 BACKGROUND: Prior systematic reviews have compared the efficacy of intravenous tenecteplase and alteplase in acute ischemic stroke, assigning their relative complications as a secondary objective. The objective of the present study is to determine whether ... Full text Link to item Cite

Serial Urinary C-C Motif Chemokine Ligand 14 and Risk of Persistent Severe Acute Kidney Injury

Journal Article Critical Care Explorations · March 1, 2023 OBJECTIVES: To assess the added prognostic value of serial monitoring of urinary C-C motif chemokine ligand 14 (uCCL14) over that of single measurements, which have been shown to be prognostic for development of persistent severe acute kidney injury (AKI) ... Full text Cite

Cortical spheroid on perfusable microvascular network in a microfluidic device.

Journal Article PLoS One · 2023 Human induced pluripotent stem cell (hiPSC)-derived brain spheroids can recapitulate the complex cytoarchitecture of the brain, as well as the genetic/epigenetic footprint of human brain development. However, hiPSC-derived 3D models such as spheroid and or ... Full text Link to item Cite

Early Vasopressor Utilization Strategies and Outcomes in Critically Ill Patients With Severe Traumatic Brain Injury.

Journal Article Anesth Analg · December 1, 2022 BACKGROUND: Early hypotension after severe traumatic brain injury (sTBI) is associated with increased mortality and poor long-term outcomes. Current guidelines suggest the use of intravenous vasopressors, commonly norepinephrine and phenylephrine, to suppo ... Full text Link to item Cite

Correction to: CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial.

Journal Article Neurocrit Care · October 2022 Full text Link to item Cite

Risk Factors and Neurological Outcomes Associated With Circulatory Shock After Moderate-Severe Traumatic Brain Injury: A TRACK-TBI Study.

Journal Article Neurosurgery · September 1, 2022 BACKGROUND: Extracranial multisystem organ failure is a common sequela of severe traumatic brain injury (TBI). Risk factors for developing circulatory shock and long-term functional outcomes of this patient subset are poorly understood. OBJECTIVE: To ident ... Full text Link to item Cite

Prophylactic treatment with CN-105 improves functional outcomes in a murine model of closed head injury.

Journal Article Exp Brain Res · September 2022 The treatment of traumatic brain injury (TBI) in military populations is hindered by underreporting and underdiagnosis. Clinical symptoms and outcomes may be mitigated with an effective pre-injury prophylaxis. This study evaluates whether CN-105, a 5-amino ... Full text Link to item Cite

Surgical Considerations to Improve Recovery in Acute Spinal Cord Injury.

Journal Article Neurospine · September 2022 Acute traumatic spinal cord injury (SCI) can be a devastating and costly event for individuals, their families, and the health system as a whole. Prognosis is heavily dependent on the physical extent of the injury and the severity of neurological dysfuncti ... Full text Link to item Cite

Effect of Acute Physical Interventions on Pathophysiology and Recovery After Spinal Cord Injury: A Comprehensive Review of the Literature.

Journal Article Neurospine · September 2022 Physical rehabilitation is essential for enhancing recovery in individuals with spinal cord injury (SCI); however, aside from early surgical intervention and hemodynamic management, there are no proven interventions for promoting recovery in the acute phas ... Full text Link to item Cite

LDL-C levels, lipid-lowering treatment and recurrent stroke in minor ischaemic stroke or TIA.

Journal Article Stroke Vasc Neurol · August 2022 BACKGROUND AND PURPOSE: Dyslipidaemia is a major risk factor for ischaemic stroke and transient ischaemic attack (TIA). This study aimed to investigate the association between baseline low-density lipoprotein cholesterol (LDL-C) level, lipid-lowering treat ... Full text Link to item Cite

An Exploratory Analysis of Biomarkers of Perihematomal Edema in the CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial.

Journal Article J Stroke Cerebrovasc Dis · August 2022 OBJECTIVE: To identify biomarkers with potential to indicate severity of perihematomal edema and secondary tissue injury after intracerebral hemorrhage (ICH), and which could be used as surrogate markers in future clinical trials for novel ICH therapeutics ... Full text Link to item Cite

Analysis of Prescriptions for Dual Antiplatelet Therapy After Acute Ischemic Stroke.

Journal Article JAMA Netw Open · July 1, 2022 IMPORTANCE: After the publication of the CHANCE (Clopidogrel in High Risk Patients With Acute Nondisabling Cerebrovascular Events) and POINT (Platelet-Oriented Inhibition in New Transient Ischemic Attack and Minor Ischemic Stroke) clinical trials, the Amer ... Full text Link to item Cite

Coupling Hematoma Evacuation with Immune Profiling for Analysis of Neuroinflammation After Primary Intracerebral Hemorrhage: A Pilot Study.

Journal Article World Neurosurg · May 2022 OBJECTIVE: We sought to explore the use and feasibility of an integrated hematoma evacuation/tissue preservation system coupled with immune profiling to assess human ex vivo immune cell populations from brain hematoma samples after intracerebral hemorrhage ... Full text Link to item Cite

Tolerability and Pharmacokinetics of Single Escalating and Repeated Doses of CN-105 in Healthy Participants.

Journal Article Clin Ther · May 2022 PURPOSE: CN-105 is an IV, apolipoprotein E-mimetic pentapeptide. Preclinical studies have reported that CN-105 effectively down-regulates neuroinflammatory responses in microglia and mitigates neuronal excitotoxicity following acute brain injury. The CN-10 ... Full text Link to item Cite

Incidence and Clinical Impact of Myocardial Injury Following Traumatic Brain Injury: A Pilot TRACK-TBI Study.

Journal Article J Neurosurg Anesthesiol · April 1, 2022 BACKGROUND: Traumatic brain injury (TBI) is a major global health problem. Little research has addressed extracranial organ dysfunction following TBI, particularly myocardial injury. Using a sensitive marker of myocardial injury-high sensitivity troponin ( ... Full text Link to item Cite

Utilization of Brain Tissue Oxygenation Monitoring and Association with Mortality Following Severe Traumatic Brain Injury.

Journal Article Neurocrit Care · April 2022 BACKGROUND: The aim of this study was to describe the utilization patterns of brain tissue oxygen (PbtO2) monitoring following severe traumatic brain injury (TBI) and determine associations with mortality, health care use, and pulmonary toxicity. METHODS: ... Full text Open Access Link to item Cite

Association of Vasopressor Choice with Clinical and Functional Outcomes Following Moderate to Severe Traumatic Brain Injury: A TRACK-TBI Study.

Journal Article Neurocrit Care · February 2022 BACKGROUND: Early hypotension following moderate to severe traumatic brain injury (TBI) is associated with increased mortality and poor long-term outcomes. Current guidelines suggest the use of intravenous vasopressors to support blood pressure following T ... Full text Link to item Cite

CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial.

Journal Article Neurocrit Care · February 2022 BACKGROUND: Endogenous apolipoprotein (apo) E mediates neuroinflammatory responses and recovery after brain injury. Exogenously administered apoE-mimetic peptides effectively penetrate the central nervous system compartment and downregulate acute inflammat ... Full text Open Access Link to item Cite

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

Journal Article Ann Clin Transl Neurol · February 2022 OBJECTIVE: Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cereb ... Full text Open Access Link to item Cite

Epidemiology and Outcomes of Acute Respiratory Distress Syndrome Following Isolated Severe Traumatic Brain Injury.

Journal Article J Intensive Care Med · January 2022 Patients with traumatic brain injury (TBI) are at risk for extra-cranial complications, such as the acute respiratory distress syndrome (ARDS). We conducted an analysis of risk factors, mortality, and healthcare utilization associated with ARDS following i ... Full text Open Access Link to item Cite

Toward Generalizable Trajectory Planning for Human Intracerebral Trials and Therapy.

Journal Article Stereotact Funct Neurosurg · 2022 INTRODUCTION: Stereotactic neurosurgical techniques are increasingly used to deliver biologics, such as cells and viruses, although standardized procedures are necessary to ensure consistency and reproducibility. OBJECTIVE: We provide an instructional guid ... Full text Link to item Cite

Optimization of a Translational Murine Model of Closed-head Traumatic Brain Injury

Preprint · 2022 Full text Cite

Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.

Journal Article Br J Anaesth · December 2021 BACKGROUND: Cognitive dysfunction after surgery is a major issue in older adults. Here, we determined the effect of APOE4 on perioperative neurocognitive function in older patients. METHODS: We enrolled 140 English-speaking patients ≥60 yr old scheduled fo ... Full text Open Access Link to item Cite

Association of Severe Acute Kidney Injury with Mortality and Healthcare Utilization Following Isolated Traumatic Brain Injury.

Journal Article Neurocrit Care · October 2021 BACKGROUND/OBJECTIVE: Traumatic brain injury (TBI) is a leading cause of morbidity, mortality, and disability in the USA. While cardiopulmonary dysfunction can result in poor outcomes following severe TBI, the impact of acute kidney injury (AKI) is poorly ... Full text Open Access Link to item Cite

Neuroprotective Pentapeptide, CN-105, Improves Outcomes in Translational Models of Intracerebral Hemorrhage.

Journal Article Neurocrit Care · October 2021 BACKGROUND: Intracerebral hemorrhage (ICH) is a devastating form of cerebrovascular disease for which there are no approved pharmacological interventions that improve outcomes. Apolipoprotein E (apoE) has emerged as a promising therapeutic target given its ... Full text Link to item Cite

Association of Early Multiple Organ Dysfunction With Clinical and Functional Outcomes Over the Year Following Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study.

Journal Article Crit Care Med · October 1, 2021 OBJECTIVES: Traumatic brain injury is a leading cause of death and disability in the United States. While the impact of early multiple organ dysfunction syndrome has been studied in many critical care paradigms, the clinical impact of early multiple organ ... Full text Link to item Cite

Multiorgan Dysfunction After Severe Traumatic Brain Injury: Epidemiology, Mechanisms, and Clinical Management.

Journal Article Chest · September 2021 Traumatic brain injury (TBI) is a major global health problem and a major contributor to morbidity and mortality following multisystem trauma. Extracranial organ dysfunction is common after severe TBI and significantly impacts clinical care and outcomes fo ... Full text Link to item Cite

Argon Inhalation for 24 h After Closed-Head Injury Does not Improve Recovery, Neuroinflammation, or Neurologic Outcome in Mice.

Journal Article Neurocrit Care · June 2021 BACKGROUND/OBJECTIVE: In recent years, the noble gas argon (Ar) has been extensively studied for its organ protection properties. While mounting in vitro and in vivo evidence indicates that argon provides neuroprotection in ischemic brain injury, its neuro ... Full text Link to item Cite

Induction of Neurogenesis and Angiogenesis in a Rat Hemisection Spinal Cord Injury Model With Combined Neural Stem Cell, Endothelial Progenitor Cell, and Biomimetic Hydrogel Matrix Therapy.

Journal Article Crit Care Explor · June 2021 UNLABELLED: Acute spinal cord injury is a devastating injury that may lead to loss of independent function. Stem-cell therapies have shown promise; however, a clinically efficacious stem-cell therapy has yet to be developed. Functionally, endothelial proge ... Full text Link to item Cite

Echocardiogram Utilization Patterns and Association With Mortality Following Severe Traumatic Brain Injury.

Journal Article Anesth Analg · April 1, 2021 BACKGROUND: Severe traumatic brain injury (TBI) can result in left ventricular dysfunction, which can lead to hypotension and secondary brain injuries. Although echocardiography is often used to examine cardiovascular function in multiple clinical settings ... Full text Open Access Link to item Cite

Changes in Informed Consent Policy and Treatment Delays in Stroke Thrombolysis.

Journal Article J Stroke Cerebrovasc Dis · March 2021 OBJECTIVES: The efficacy of thrombolytic therapy with tissue plasminogen activator (tPA) is highly time dependent. Although clinical guidelines do not recommend written informed consent as it may cause treatment delays, local policy can supersede and requi ... Full text Open Access Link to item Cite

First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers.

Journal Article Clin Pharmacol Drug Dev · February 2021 MW01-6-189WH (MW189) is a novel central nervous system-penetrant small-molecule drug candidate that selectively attenuates stressor-induced proinflammatory cytokine overproduction and is efficacious in intracerebral hemorrhage and traumatic brain injury an ... Full text Link to item Cite

Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2021 BACKGROUND: Postoperative cognitive dysfunction (POCD), a syndrome of cognitive deficits occurring 1-12 months after surgery primarily in older patients, is associated with poor postoperative outcomes. POCD is hypothesized to result from neuroinflammation; ... Full text Open Access Link to item Cite

Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes.

Journal Article Microsyst Nanoeng · 2021 Traumatic brain injury (TBI) is a global cause of morbidity and mortality. Initial management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiographic studies as well as by the absence of a wide ... Full text Link to item Cite

Emergency medical services use and its association with acute ischaemic stroke evaluation and treatment in Singapore.

Journal Article Stroke Vasc Neurol · June 2020 BACKGROUND: Emergency medical services (EMS) is a critical link in the chain of stroke survival. We aimed to assess EMS use for stroke in Singapore, identify characteristics associated with EMS use and the association of EMS use with stroke evaluation and ... Full text Open Access Link to item Cite

Author Correction: Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage.

Journal Article Sci Rep · April 20, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

ApoE mimetic improves pathology and memory in a model of Alzheimer's disease.

Journal Article Brain Res · April 15, 2020 Alzheimer's disease (AD) is the most common form of dementia and is characterized pathologically by Aβ plaques. Current treatments are purely symptomatic despite decades of intensive research interest. Notably, patients with the APOE4 allele are at increas ... Full text Link to item Cite

Speckle Tracking Analysis of Left Ventricular Systolic Function Following Traumatic Brain Injury: A Pilot Prospective Observational Cohort Study.

Journal Article J Neurosurg Anesthesiol · April 2020 BACKGROUND: Systolic dysfunction and reduction in left ventricular ejection fraction (LVEF) has been documented after traumatic brain injury (TBI). Speckle tracking is an emerging technology for myocardial strain assessment which has been utilized to ident ... Full text Link to item Cite

Therapeutic Development of Apolipoprotein E Mimetics for Acute Brain Injury: Augmenting Endogenous Responses to Reduce Secondary Injury.

Journal Article Neurotherapeutics · April 2020 Over the last few decades, increasing evidence demonstrates that the neuroinflammatory response is a double-edged sword. Although overly robust inflammatory responses may exacerbate secondary tissue injury, inflammatory processes are ultimately necessary f ... Full text Open Access Link to item Cite

Worldwide Organization of Neurocritical Care: Results from the PRINCE Study Part 1.

Journal Article Neurocrit Care · February 2020 INTRODUCTION: Neurocritical care focuses on the care of critically ill patients with an acute neurologic disorder and has grown significantly in the past few years. However, there is a lack of data that describe the scope of practice of neurointensivists a ... Full text Link to item Cite

Global Survey of Outcomes of Neurocritical Care Patients: Analysis of the PRINCE Study Part 2.

Journal Article Neurocrit Care · February 2020 BACKGROUND: Neurocritical care is devoted to the care of critically ill patients with acute neurological or neurosurgical emergencies. There is limited information regarding epidemiological data, disease characteristics, variability of clinical care, and i ... Full text Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Neuroprotective pentapeptide, CN-105, improves outcomes in translational models of intracerebral hemorrhage

Journal Article · 2020 Background Intracerebral hemorrhage (ICH) is a devastating form of cerebrovascular disease for which there are no approved pharmacological interventions that improve outcomes. Apolipoprotein E (apoE) has emerged as a promising therapeutic target g ... Full text Cite

COVID-19-Associated Guillain-Barre Syndrome: Atypical Para-infectious Profile, Symptom Overlap, and Increased Risk of Severe Neurological Complications.

Journal Article SN Compr Clin Med · 2020 The concurrence of COVID-19 with Guillain-Barre syndrome (GBS) can increase the likelihood of neuromuscular respiratory failure, autonomic dysfunction, and other life-threatening symptoms. Currently, very little is known about the underlying mechanisms, cl ... Full text Open Access Link to item Cite

The MARBLE Study: Modulating ApoE signaling to Reduce Brain inflammation, deLirium, and postopErative Cognitive Dysfunction

Conference ANESTHESIA AND ANALGESIA · 2020 Cite

Effect of dual versus mono antiplatelet therapy on recurrent stroke modulated by activated partial thromboplastin time.

Journal Article Eur J Neurol · September 2019 BACKGROUND AND PURPOSE: The efficacy of dual antiplatelet treatment may be modified by many factors. The aim was to assess whether the effect of clopidogrel plus aspirin versus aspirin alone on recurrent stroke would be affected by admission activated part ... Full text Link to item Cite

Acute Decrease in Flow in the Right Middle Cerebral Artery Detected by Transcranial Doppler Following High-Intensity Transient Signals in a Patient With Carotid Artery Dissection

Journal Article Journal for Vascular Ultrasound · June 1, 2019 We report a case of evolving multiple vascular dissections where transcranial Doppler with emboli monitoring provided evidence of hemodynamic compromise after microembolic high-intensity signals suggested a clinical change in a patient presenting with a si ... Full text Cite

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.

Journal Article Anesthesiology · June 2019 BACKGROUND: Cognitive decline after cardiac surgery occurs frequently and persists in a significant proportion of patients. Preclinical studies and human trials suggest that intravenous lidocaine may confer protection in the setting of neurologic injury. I ... Full text Open Access Link to item Cite

Sex Differences in Gene and Protein Expression After Intracerebral Hemorrhage in Mice.

Journal Article Transl Stroke Res · April 2019 Sex dimorphism has been demonstrated after experimental intracerebral hemorrhage (ICH). Decreased mortality and improved neurobehavioral outcomes occur in female compared to male mice after intrastriatal autologous blood or collagenase injection. Sex-speci ... Full text Link to item Cite

Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening.

Journal Article PloS one · January 2019 We investigated a potential use of a 3D tetraculture brain microphysiological system (BMPS) for neurotoxic chemical agent screening. This platform consists of neuronal tissue with extracellular matrix (ECM)-embedded neuroblastoma cells, microglia, and astr ... Full text Cite

Bone Marrow T-Cell Sequestration and Lymphopenia Accompanying Ischemic Stroke are Mediated by T-Cell S1P1 Loss

Conference NEUROSURGERY · 2019 Cite

Apolipoprotein E mimetic peptide CN-105 improves outcome in a murine model of SAH.

Journal Article Stroke Vasc Neurol · December 2018 OBJECTIVE: Subarachnoid haemorrhage (SAH) accounts for 3% of all strokes, and is associated with significant morbidity and mortality. There is growing evidence implicating apolipoprotein E (apoE) in mediating adaptive anti-inflammatory and neuroprotective ... Full text Link to item Cite

International Comparison of Patient Characteristics and Quality of Care for Ischemic Stroke: Analysis of the China National Stroke Registry and the American Heart Association Get With The Guidelines--Stroke Program.

Journal Article J Am Heart Assoc · October 16, 2018 Background Adherence to evidence-based guidelines is an important quality indicator; yet, there is lack of assessment of adherence to performance measures in acute ischemic stroke for most world regions. Methods and Results We analyzed 19 604 patients with ... Full text Open Access Link to item Cite

The Effect of the Relationship of APOE Polymorphisms and Cerebral Vasospasm on Functional Outcomes in Children With Traumatic Brain Injury.

Journal Article Biol Res Nurs · October 2018 BACKGROUND: Pediatric traumatic brain injury (TBI) is a leading cause of death and disability. Polymorphisms in the apolipoprotein E ( APOE) gene have been linked to cerebral vasospasm (CV) and poor outcomes in adults with TBI, yet these associations remai ... Full text Link to item Cite

Intravenous tPA (Tissue-Type Plasminogen Activator) in Patients With Acute Ischemic Stroke Taking Non-Vitamin K Antagonist Oral Anticoagulants Preceding Stroke.

Journal Article Stroke · September 2018 Background and Purpose- Although there are no trials or large cohorts to inform clinical care, current guidelines caution against giving intravenous tPA (tissue-type plasminogen activator) to patients with acute ischemic stroke who are taking non-vitamin K ... Full text Link to item Cite

Associations between Patient Characteristics and a New, Early Do-Not-Attempt Resuscitation Order after Intracerebral Hemorrhage.

Journal Article J Palliat Med · August 2018 BACKGROUND: Decisions to limit care, including use of a do-not-resuscitate (DNR) order, are associated with increased risk of death after intracerebral hemorrhage (ICH). Given the value that patient surrogates place on the physician's perception of prognos ... Full text Link to item Cite

Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke: Clinical Outcomes from a Phase I Safety Study.

Journal Article Stem Cells Transl Med · July 2018 Stroke is a major cause of death and long-term disability, affecting one in six people worldwide. The only currently available approved pharmacological treatment for ischemic stroke is tissue plasminogen activator; however, relatively few patients are elig ... Full text Open Access Link to item Cite

18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.

Journal Article Anesthesiology · April 2018 BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patie ... Full text Link to item Cite

Apixaban following acute coronary syndromes in patients with prior stroke: Insights from the APPRAISE-2 trial.

Journal Article American heart journal · March 2018 Background and purposePatients with prior stroke are at greater risk for recurrent cardiovascular events post-acute coronary syndromes (ACS) and may have a different risk/benefit profile with antithrombotic therapy than patients without prior stro ... Full text Cite

Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study.

Journal Article Br J Sports Med · February 2018 BACKGROUND/AIM: To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser53Pro, MAPT/tau Hist47Tyr, IL-6572 G/C and IL-6RAsp358Ala with the risk of concussion in college athletes. M ... Full text Link to item Cite

Association of IL6ST (gp130) Polymorphism with Functional Outcome Following Spontaneous Intracerebral Hemorrhage.

Journal Article J Stroke Cerebrovasc Dis · January 2018 BACKGROUND AND PURPOSE: Genes associated with the inflammatory response and cytostructural integrity may influence recovery following a brain injury. To examine this in the setting of spontaneous intracerebral hemorrhage (ICH), selected single nucleotide p ... Full text Link to item Cite

Posttraumatic Seizures

Chapter · January 1, 2018 Posttraumatic seizures are relatively common following moderate to severe brain injury, although the mechanisms by which this occurs remain incompletely defined. A number of conventional antiepileptic drugs have proven effective in suppressing early seizur ... Full text Cite

Depression Status Is Associated with Functional Decline Over 1-Year Following Acute Stroke.

Journal Article J Stroke Cerebrovasc Dis · July 2017 BACKGROUND: We investigated the independent association of depression status at 3 and 12 months after stroke and functional decline. METHODS: Data were obtained as part of the multicenter Adherence eValuation After Ischemic stroke Longitudinal (AVAIL) regi ... Full text Link to item Cite

Preventing Episodic Migraine With Caloric Vestibular Stimulation: A Randomized Controlled Trial.

Journal Article Headache · July 2017 OBJECTIVE: To evaluate the safety and efficacy of a novel solid-state, caloric vestibular stimulation (CVS) device to provide adjuvant therapy for the prevention of episodic migraine in adult migraineurs. BACKGROUND: Migraine causes significant disability ... Full text Link to item Cite

Phase 1 Randomized, Double-Blind, Placebo-Controlled Study to Determine the Safety, Tolerability, and Pharmacokinetics of a Single Escalating Dose and Repeated Doses of CN-105 in Healthy Adult Subjects.

Journal Article J Clin Pharmacol · June 2017 Spontaneous intracranial hemorrhage (ICH) remains a devastating stroke subtype, affecting as many as 80,000 people annually in the United States and associated with extremely high mortality. In the absence of any pharmacological interventions demonstrated ... Full text Link to item Cite

Comparison of Associations of Reduced Estimated Glomerular Filtration Rate With Stroke Outcomes Between Hypertension and No Hypertension.

Journal Article Stroke · June 2017 Background and purposeWe compared the association of low estimated glomerular filtration rate (eGFR) with stroke outcomes among patients with hypertension and without hypertension.MethodsWe used the China stroke registry to identify patie ... Full text Cite

Neuroprotective pentapeptide CN-105 is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model.

Journal Article Sci Rep · April 21, 2017 At present, there are no proven pharmacological treatments demonstrated to improve long term functional outcomes following traumatic brain injury(TBI). In the setting of non-penetrating TBI, sterile brain inflammatory responses are associated with the deve ... Full text Link to item Cite

Apolipoprotein E mimetic peptide, CN-105, improves outcomes in ischemic stroke.

Journal Article Annals of clinical and translational neurology · April 2017 ObjectiveAt present, the absence of a pharmacological neuroprotectant represents an important unmet clinical need in the treatment of ischemic and traumatic brain injury. Recent evidence suggests that administration of apolipoprotein E mimetic the ... Full text Cite

Use of Intravenous Recombinant Tissue Plasminogen Activator in Patients With Acute Ischemic Stroke Who Take Non-Vitamin K Antagonist Oral Anticoagulants Before Stroke.

Journal Article Circulation · March 14, 2017 BACKGROUND: Intravenous rt-PA (recombinant tissue-type plasminogen activator) is effective in improving outcomes in ischemic stroke; however, there are few data on the use of rt-PA in patients who are receiving a non-vitamin K antagonist oral anticoagulant ... Full text Link to item Cite

Erratum: Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage.

Journal Article Sci Rep · January 5, 2017 Full text Open Access Link to item Cite

Multicenter cohort study on association of genotypes with prospective sports concussion: methods, lessons learned, and recommendations.

Journal Article J Sports Med Phys Fitness · 2017 BACKGROUND: Approximately 3.8 million sports related TBIs occur per year. Genetic variation may affect both TBI risk and post-TBI clinical outcome. Limited research has focused on genetic risk for concussion among athletes. We describe the design, methods, ... Full text Link to item Cite

A blood-based biomarker panel to risk-stratify mild traumatic brain injury.

Journal Article PloS one · January 2017 Mild traumatic brain injury (TBI) accounts for the vast majority of the nearly two million brain injuries suffered in the United States each year. Mild TBI is commonly classified as complicated (radiographic evidence of intracranial injury) or uncomplicate ... Full text Open Access Cite

The Effect of Propofol vs. Isoflurane Anesthesia on Postoperative Changes in Cerebrospinal Fluid Cytokine Levels: Results from a Randomized Trial.

Journal Article Front Immunol · 2017 INTRODUCTION: Aside from direct effects on neurotransmission, inhaled and intravenous anesthetics have immunomodulatory properties. In vitro and mouse model studies suggest that propofol inhibits, while isoflurane increases, neuroinflammation. If these fin ... Full text Link to item Cite

Therapeutic Human Umbilical Cord Blood Cells in Ischemic Stroke

Conference STROKE · 2017 Cite

Posttraumatic Seizures

Chapter · January 1, 2017 Posttraumatic seizures are relatively common following moderate to severe brain injury, although the mechanisms by which this occurs remain incompletely defined. A number of conventional antiepileptic drugs have proven effective in suppressing early seizur ... Full text Cite

Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage.

Journal Article Sci Rep · October 7, 2016 Presently, no pharmacological treatments have been demonstrated to improve long-term functional outcomes following intracerebral hemorrhage (ICH). Clinical evidence associates apolipoprotein E (apoE) genotype with ICH incidence and outcome. While apoE modi ... Full text Open Access Link to item Cite

NP10679: A pH-sensitive GluN2B Inhibitor to Improve Outcomes Postsubarachnoid Hemorrhage by Preventing Ischemic Neuronal Damage

Conference NEUROTHERAPEUTICS · July 1, 2016 Link to item Cite

Opposing effects of traumatic brain injury on excitatory synaptic function in the lateral amygdala in the absence and presence of preinjury stress.

Journal Article J Neurosci Res · June 2016 Traumatic brain injury (TBI) is a leading cause of death and disability among young adults and is highly prevalent among recently deployed military personnel. Survivors of TBI often experience cognitive and emotional deficits, suggesting that long-term eff ... Full text Link to item Cite

Genetic influences in traumatic brain injury

Chapter · April 21, 2016 Cite

Cellular and molecular mechanisms of secondary neuronal injury following traumatic brain injury

Chapter · April 21, 2016 Cite

Translational research in traumatic brain injury

Book · April 21, 2016 Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resour ... Cite

The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial.

Journal Article J Alzheimers Dis · April 15, 2016 BACKGROUND: Preclinical studies have found differential effects of isoflurane and propofol on the Alzheimer's disease (AD)-associated markers tau, phosphorylated tau (p-tau) and amyloid-β (Aβ). OBJECTIVE: We asked whether isoflurane and propofol have diffe ... Full text Open Access Link to item Cite

Progesterone Improves Neurobehavioral Outcome in Models of Intracerebral Hemorrhage.

Conference Neuroendocrinology · 2016 In models of acute brain injury, progesterone improves recovery through several mechanisms including modulation of neuroinflammation. Secondary injury from neuroinflammation is a potential therapeutic target after intracerebral hemorrhage (ICH). For potent ... Full text Link to item Cite

Risks and Benefits Associated With Prestroke Antiplatelet Therapy Among Patients With Acute Ischemic Stroke Treated With Intravenous Tissue Plasminogen Activator.

Journal Article JAMA neurology · January 2016 ImportanceIntravenous tissue plasminogen activator (tPA) is known to improve outcomes in ischemic stroke; however, many patients may have been receiving antiplatelet therapy before acute ischemic stroke and could face an increased risk for bleedin ... Full text Open Access Cite

Peak Systolic Velocity Measurements with Transcranial Doppler Ultrasound Is a Predictor of Incident Stroke among the General Population in China.

Journal Article PLoS One · 2016 BACKGROUND AND OBJECTIVE: It is necessary to develop an effective and low-cost screening tool for identifying Chinese people at high risk of stroke. Transcranial Doppler ultrasound (TCD) is a powerful predictor of stroke in the pediatric sickle cell diseas ... Full text Open Access Link to item Cite

Non-Invasive Neuromodulation Using Time-Varying Caloric Vestibular Stimulation.

Journal Article IEEE J Transl Eng Health Med · 2016 Caloric vestibular stimulation (CVS) to elicit the vestibulo-ocular reflex has long been used in clinical settings to aid in the diagnosis of balance disorders and to confirm the absence of brainstem function. While a number of studies have hinted at the p ... Full text Link to item Cite

Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort.

Journal Article Atherosclerosis · November 2015 BACKGROUND: Carotid artery intima media thickness (IMT) in human is a marker of subclinical atherosclerosis with high heritability. Many genome-wide association studies (GWAS) were performed in European and American populations, yet discovery efforts have ... Full text Link to item Cite

Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.

Journal Article Kidney Int · October 2015 Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide association study (GWAS) for AKI following coronary bypass graft (CABG) sur ... Full text Open Access Link to item Cite

Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association.

Journal Article Circulation · September 1, 2015 The year 2014 marked the 20th anniversary of the coining of the term proteomics. The purpose of this scientific statement is to summarize advances over this period that have catalyzed our capacity to address the experimental, translational, and clinical im ... Full text Link to item Cite

Apolipoprotein epsilon 4 genotype is associated with less improvement in cognitive function five years after cardiac surgery: a retrospective cohort study.

Journal Article Can J Anaesth · June 2015 PURPOSE: Cognitive performance after cardiac surgery can be impaired, and genetic risk factors have previously been suggested. When compared with other isoforms of the gene, the apolipoprotein epsilon 4 (APOE4) allele is associated with worse outcomes in m ... Full text Link to item Cite

Neighborhood socioeconomic status and the prevalence of stroke and coronary heart disease in rural China: a population-based study.

Journal Article Int J Stroke · April 2015 BACKGROUND: Lower neighborhood-level socioeconomic status (SES) is associated with an increased risk of vascular disease in developed countries. AIMS: This study aims to identify village- and individual-level determinants of stroke and coronary heart disea ... Full text Link to item Cite

APIXABAN FOLLOWING ACUTE CORONARY SYNDROMES AMONG PATIENTS WITH PRIOR STROKE: INSIGHTS FROM THE APPRAISE-2 TRIAL

Conference Journal of the American College of Cardiology · March 2015 Full text Cite

Congenital absence of apolipoprotein E and neurological function.

Journal Article JAMA Neurol · December 2014 Full text Link to item Cite

G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockers.

Other Circ Cardiovasc Genet · October 2014 BACKGROUND: We hypothesized that genetic variations in the adrenergic signaling pathway and cytochrome P450 2D6 enzyme are associated with new-onset atrial fibrillation (AF) in patients who underwent coronary artery bypass grafting and were treated with pe ... Full text Link to item Cite

Translational research in acute central nervous system injury: lessons learned and the future.

Journal Article JAMA Neurol · October 2014 IMPORTANCE: Research to improve outcomes from acute central nervous system (CNS) injury has progressed little, although limited examples (eg, induced hypothermia for out-of-hospital ventricular fibrillation cardiac arrest and birth asphyxia and tissue plas ... Full text Link to item Cite

Statins and delirium during critical illness: a multicenter, prospective cohort study.

Journal Article Crit Care Med · August 2014 OBJECTIVE: Since statins have pleiotropic effects on inflammation and coagulation that may interrupt delirium pathogenesis, we tested the hypotheses that statin exposure is associated with reduced delirium during critical illness, whereas discontinuation o ... Full text Link to item Cite

Intrastriatal injection of autologous blood or clostridial collagenase as murine models of intracerebral hemorrhage.

Journal Article J Vis Exp · July 3, 2014 Intracerebral hemorrhage (ICH) is a common form of cerebrovascular disease and is associated with significant morbidity and mortality. Lack of effective treatment and failure of large clinical trials aimed at hemostasis and clot removal demonstrate the nee ... Full text Open Access Link to item Cite

Genetic influences and neuropathological sequelae of repetitive brain injury.

Journal Article Ann Neurol · April 2014 Full text Link to item Cite

Response to letter regarding article, "Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery".

Journal Article Stroke · March 2014 Full text Link to item Cite

pH-sensitive NMDA inhibitors improve outcome in a murine model of SAH.

Journal Article Neurocrit Care · February 2014 BACKGROUND: Despite intensive research, neurological morbidity from delayed cerebral ischemia remains common after aneurysmal subarachnoid hemorrhage (SAH). In the current study, we evaluate the neuroprotective effects of a pH-dependent GluN2B subunit-sele ... Full text Link to item Cite

The role of neuroendocrine pathways in prognosis after stroke.

Journal Article Expert Rev Neurother · February 2014 A number of neuroendocrine changes have been described after stroke, which may serve adaptive or deleterious functions. The neuroendocrine changes include activation of the hypothalamo-pituitary-adrenal axis, sympathetic nervous system and alterations of s ... Full text Link to item Cite

Sports Concussion Management: part II.

Journal Article South Med J · February 2014 Millions of concussions occur every year in the United States. The public interest in concussion has increased after a number of high-profile deaths in high school athletes from sports-related head trauma and in some professional athletes from chronic trau ... Full text Link to item Cite

Predictors of extraventricular drain-associated bacterial ventriculitis.

Journal Article J Crit Care · February 2014 PURPOSE: Bacterial ventriculitis (BV) may develop in patients requiring external ventricular drains (EVDs). The purpose of this study was to determine predictors of EVD-associated BV onset. MATERIALS AND METHODS: A retrospective review of Duke University H ... Full text Link to item Cite

3-D transcranial ultrasound imaging with bilateral phase aberration correction of multiple isoplanatic patches: a pilot human study with microbubble contrast enhancement.

Journal Article Ultrasound Med Biol · January 2014 With stroke currently the second-leading cause of death globally, and 87% of all strokes classified as ischemic, the development of a fast, accessible, cost-effective approach for imaging occlusive stroke could have a significant impact on health care outc ... Full text Link to item Cite

Cardiovascular manifestations of neurologic disease.

Journal Article Handb Clin Neurol · 2014 Cardiac manifestations of neurologic diseases are common in clinical practice. There are numerous anatomic and pathophysiologic links between the normal and abnormal function of both systems. There are a number of brain-heart interactions which affect the ... Full text Link to item Cite

Baseline health-related quality of life and 10-year all-cause mortality among 1739 Chinese adults.

Journal Article PLoS One · 2014 BACKGROUND AND PURPOSE: Health-related quality of life (HRQOL) may be associated with the longevity of patients; yet it is not clear whether this association holds in a general population, especially in low- and middle-income countries. The objective of th ... Full text Link to item Cite

Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia.

Journal Article PLoS One · 2014 Female sex is associated with improved outcome in experimental brain injury models, such as traumatic brain injury, ischemic stroke, and intracerebral hemorrhage. This implies female gonadal steroids may be neuroprotective. A mechanism for this may involve ... Full text Open Access Link to item Cite

A blood-based biomarker panel to detect acute stroke.

Journal Article J Stroke Cerebrovasc Dis · 2014 BACKGROUND: The aim of this study was to develop an adjunctive, peripheral biomarker test to differentiate ischemic strokes, intracranial hemorrhages (ICHs), and stroke mimics in the acute setting. METHODS: Serum samples were collected from 167 patients wh ... Full text Link to item Cite

Predictors of late neurological deterioration after spontaneous intracerebral hemorrhage.

Journal Article Neurocrit Care · December 2013 BACKGROUND: Although intracerebral hemorrhage (ICH) is a common form of cerebrovascular disease, little is known about factors leading to neurological deterioration occurring beyond 48 h after hematoma formation. The purpose of this study was to characteri ... Full text Link to item Cite

Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery.

Journal Article Stroke · December 2013 BACKGROUND AND PURPOSE: Neurocognitive decline occurs frequently after cardiac surgery and persists in a significant number of patients. Magnesium is thought to provide neuroprotection by preservation of cellular energy metabolism, blockade of the N-methyl ... Full text Link to item Cite

Gender and age interact to affect early outcome after intracerebral hemorrhage

Journal Article PLoS ONE · November 27, 2013 Background: Intracerebral hemorrhage (ICH) is a common and devastating form of cerebrovascular disease. In ICH, gender differences in outcomes remain relatively understudied but have been examined in other neurological emergencies. Further, a potential eff ... Full text Cite

ApoE and outcome after traumatic brain injury

Journal Article Clinical Lipidology · October 1, 2013 There is increasing evidence to support the role of genetic influences in determining functional outcomes in subjects with traumatic brain injury. In particular, apoE polymorphism has been identified as one of the important determinants of prognosis after ... Full text Cite

Tumor necrosis factor α antagonism improves neurological recovery in murine intracerebral hemorrhage.

Journal Article J Neuroinflammation · August 20, 2013 BACKGROUND: Intracerebral hemorrhage (ICH) is a devastating stroke subtype characterized by a prominent neuroinflammatory response. Antagonism of pro-inflammatory cytokines by specific antibodies represents a compelling therapeutic strategy to improve neur ... Full text Open Access Link to item Cite

Lacosamide improves outcome in a murine model of traumatic brain injury.

Journal Article Neurocrit Care · August 2013 BACKGROUND: Use of antiepileptic drugs (AED's) is common in the neurocritical care setting. However, there remains a great deal of controversy regarding the optimal agent. Studies associating the prophylactic use of AED's with poor outcomes are heavily bia ... Full text Link to item Cite

Teaching neuroimages: vein of Galen aneurysm mimicking pineal mass in a young adult.

Journal Article Neurology · May 28, 2013 A 22-year-old man presented with intractable progressive headaches over 2 months. Noncontrast head CT and contrast-enhanced MRI scan revealed a hyperdense pineal-based mass (figure, A and B). Arteriogram was normal (figure, C and D). ... Full text Link to item Cite

Simultaneous bilateral real-time 3-d transcranial ultrasound imaging at 1 MHz through poor acoustic windows.

Journal Article Ultrasound Med Biol · April 2013 Ultrasound imaging has been proposed as a rapid, portable alternative imaging modality to examine stroke patients in pre-hospital or emergency room settings. However, in performing transcranial ultrasound examinations, 8%-29% of patients in a general popul ... Full text Link to item Cite

Stroke after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction: timing, characteristics, and clinical outcomes.

Journal Article Circ Cardiovasc Interv · April 2013 BACKGROUND: Stroke is a rare but potentially devastating complication of acute myocardial infarction. Little is known about stroke timing, characteristics, and clinical outcomes in patients with ST-segment elevation myocardial infarction treated with prima ... Full text Link to item Cite

ApolipoproteinE mimetic peptides improve outcome after focal ischemia.

Journal Article Exp Neurol · March 2013 Growing clinical evidence implicates isoform-specific effects of apolipoprotein E (apoE) in reducing neuroinflammation and mediating adaptive responses following ischemic and traumatic brain injury. However, the intact apoE holoprotein does not cross the b ... Full text Link to item Cite

Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury.

Journal Article Crit Care · February 6, 2013 INTRODUCTION: Acute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely to provide benefit. Identifying early markers of kidney damage has been difficult due to the compl ... Full text Link to item Cite

Gender and age interact to affect early outcome after intracerebral hemorrhage.

Journal Article PLoS One · 2013 BACKGROUND: Intracerebral hemorrhage (ICH) is a common and devastating form of cerebrovascular disease. In ICH, gender differences in outcomes remain relatively understudied but have been examined in other neurological emergencies. Further, a potential eff ... Full text Open Access Link to item Cite

Letter by El Husseini et al regarding article, "What causes disability after transient ischemic attack and minor stroke?".

Journal Article Stroke · December 2012 Full text Link to item Cite

Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity.

Journal Article The Journal of biological chemistry · December 2012 The plasma lipoprotein-associated apolipoproteins (apo) A-I and apoE have well described anti-inflammatory actions in the cardiovascular system, and mimetic peptides that retain these properties have been designed as therapeutics. The anti-inflammatory mec ... Full text Cite

Biomarkers in traumatic brain injury.

Journal Article Curr Neurol Neurosci Rep · October 2012 Traumatic brain injury (TBI) is a common cause of neurological morbidity globally, and neurologic sequelae may occur even in the setting of mild injury. At present, the tools that guide diagnostic and prognostic evaluation of patients who suffer from TBI r ... Full text Link to item Cite

Correlation of leukocytosis with early neurological deterioration following supratentorial intracerebral hemorrhage.

Journal Article J Clin Neurosci · August 2012 Intracerebral hemorrhage (ICH) is a devastating and common admitting diagnosis to intensive care units in the USA. Despite advances in critical care, patients with ICH often experience early neurological deterioration (END) in the first 72 hours after admi ... Full text Link to item Cite

Depression and antidepressant use after stroke and transient ischemic attack.

Journal Article Stroke · June 2012 BACKGROUND AND PURPOSE: Patients with stroke and transient ischemic attack (TIA) often have comparable comorbidities, but it is unclear whether they have similar rates of depression or antidepressant use. METHODS: This study was a secondary analysis of a p ... Full text Link to item Cite

TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice.

Journal Article Anesthesiology · June 2012 BACKGROUND: Microglial inhibition may reduce secondary tissue injury and improve functional outcome following acute brain injury. Utilizing clinically relevant murine models of traumatic brain injury and intracerebral hemorrhage, neuroinflammatory response ... Full text Link to item Cite

Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: a translational approach.

Journal Article J Neurotrauma · May 1, 2012 Traumatic brain injury (TBI) and intracerebral hemorrhage (ICH) are leading causes of neurological mortality and disability in the U.S. However, therapeutic options are limited and clinical management remains largely supportive. HMG-CoA reductase inhibitor ... Full text Link to item Cite

The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage.

Journal Article Neurocritical care · April 2012 BackgroundApolipoprotein E has previously been demonstrated to modulate acute brain injury responses, and administration of COG1410, an apoE-mimetic peptide derived from the receptor-binding region of apoE, improves outcome in preclinical models o ... Full text Cite

Evolving role of biomarkers in acute cerebrovascular disease.

Journal Article Ann Neurol · March 2012 The development of a clinically validated biomarker of acute cerebral ischemia would have the potential to facilitate the use of time-sensitive reperfusion strategies, allow for individualization of patient care by predicting relative risk of hemorrhage an ... Full text Link to item Cite

Interaction between sex and apolipoprotein e genetic background in a murine model of intracerebral hemorrhage.

Journal Article Transl Stroke Res · March 2012 Emerging evidence suggests sex and apolipoprotein E (APOE) genotype separately modify outcomes after intracerebral hemorrhage (ICH). We test the hypothesis that an interaction exists between sex and APOE polymorphism in modifying outcomes after ICH and is ... Full text Link to item Cite

Use of emergency department transcranial Doppler assessment of reperfusion after intravenous tPA for ischemic stroke.

Journal Article J Emerg Med · January 2012 Featured Publication BACKGROUND: Thrombolysis with intravenous recombinant tissue plasminogen activator (IV-tPA) has been associated with significant improvements in clinical outcomes when initiated within 3 h of symptom onset. Although adjunctive therapies for acute stroke ha ... Full text Link to item Cite

Discriminative capacity of biomarkers for acute stroke in the emergency department.

Journal Article J Emerg Med · September 2011 BACKGROUND: Acute ischemic stroke remains largely a clinical diagnosis. OBJECTIVE: To assess the potential of several biomarkers to distinguish acute ischemic stroke from mimics in the emergency department (ED). METHODS: In this prospective study, 63 patie ... Full text Link to item Cite

Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.

Journal Article Ann Thorac Surg · June 2011 BACKGROUND: Inclusion of a measure of left ventricular diastolic dysfunction (LVDD) may improve risk prediction after cardiac surgery. Current LVDD grading guidelines rely on echocardiographic variables that are not always available or aligned to allow gra ... Full text Link to item Cite

The ultrasound brain helmet: new transducers and volume registration for in vivo simultaneous multi-transducer 3-D transcranial imaging.

Journal Article IEEE Trans Ultrason Ferroelectr Freq Control · June 2011 Because stroke remains an important and time-sensitive health concern in developed nations, we present a system capable of fusing 3-D transcranial ultrasound volumes acquired from two sides of the head. This system uses custom sparse array transducers buil ... Full text Link to item Cite

Developing Physician Leaders for Over 50 years: The Duke Medical Student Research Experience in the US and Singapore

Journal Article Medical Science Educator · April 1, 2011 Duke University has long incorporated research into its medical school curriculum. Its sister school, Duke-National University of Singapore, adopted the same model to inculcate a culture of research and develop graduates with a strong scientific foundation ... Full text Cite

A reversible aptamer improves outcome and safety in murine models of stroke and hemorrhage.

Journal Article Oligonucleotides · February 2011 Treatment of acute ischemic stroke with intravenous tissue-type plasminogen activator is underutilized partly due to the risk of life-threatening hemorrhage. In response to the clinical need for safer stroke therapy, we explored using an aptamer-based ther ... Full text Link to item Cite

Animal models of frontotemporal dementia

Journal Article Neuromethods · January 11, 2011 Frontotemporal dementia (FTD) is a multifaceted syndrome with a high degree of clinical and -neuropathological variability, an extensive genetic contribution, and involvement of multiple proteins. FTD accounts for up to 50% of dementias with the onset prio ... Full text Cite

In reply

Journal Article Academic Medicine · January 1, 2011 Full text Cite

Progressive multifocal leukoencephalopathy with occult Waldenström macroglobulinemia.

Journal Article J Clin Oncol · December 20, 2010 Full text Link to item Cite

Dual matrix arrays integrated into scanner for increased SNR of ultrasound brain helmet

Journal Article Proceedings - IEEE Ultrasonics Symposium · December 1, 2010 In response to the high prevalence of stroke, we propose a system for scanning simultaneously via both temporal bone windows. The characteristics of this window and system limitations guide the design of custom matrix arrays. We present operational arrays ... Full text Cite

Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic.

Journal Article J Neurotrauma · November 2010 Cognitive impairment is common following traumatic brain injury (TBI), and neuroinflammatory mechanisms may predispose to the development of neurodegenerative disease. Apolipoprotein E (apoE) polymorphisms modify neuroinflammatory responses, and influence ... Full text Open Access Link to item Cite

NIH Roundtable on Opportunities to Advance Research on Neurologic and Psychiatric Emergencies.

Journal Article Ann Emerg Med · November 2010 STUDY OBJECTIVE: The Institute of Medicine Committee on the Future of Emergency Care in the United States Health System (2003) identified a need to enhance the research base for emergency care. As a result, a National Institutes of Health (NIH) Task Force ... Full text Link to item Cite

Neuroprotection in subarachnoid hemorrhage.

Journal Article Stroke · October 2010 Despite advances in aneurysm ablation and the initial management of patients presenting with aneurysmal subarachnoid hemorrhage, delayed cerebral ischemia remains a significant source of morbidity. Traditionally, delayed cerebral ischemia was thought to be ... Full text Link to item Cite

Biomarkers in stroke: when will they impact care?

Journal Article J Am Coll Cardiol · September 21, 2010 Full text Link to item Cite

Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease.

Journal Article Neuroscience · August 2010 A central issue in the pathogenesis of tauopathy is the question of how tau protein dysfunction leads to neurodegeneration. We have previously demonstrated that the absence of tau protein is associated with destabilization of microtubules and impaired neur ... Full text Cite

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease.

Journal Article Neurology · June 15, 2010 Full text Link to item Cite

Defining optimal cerebral perfusion pressures in acute brain injury: a step toward individualization of care?

Journal Article Crit Care Med · May 2010 Full text Link to item Cite

Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury.

Other Anesthesiology · April 2010 BACKGROUND: Postoperative cognitive dysfunction (POCD) is a significant cause of morbidity after noncardiac surgery. Identified risk factors are largely limited to demographic characteristics. We hypothesized that POCD was associated with apolipoprotein E4 ... Full text Link to item Cite

Engaging students in dedicated research and scholarship during medical school: the long-term experiences at Duke and Stanford.

Journal Article Acad Med · March 2010 For more than 40 years, the faculties of Duke University School of Medicine (SOM) and Stanford University SOM have encouraged or required students to engage in scholarship as a way to broaden their education and attract them to careers in academic medicine ... Full text Link to item Cite

Clinical application of blood biomarkers in cerebrovascular disease.

Journal Article Expert Rev Neurother · February 2010 Identifying a biomarker or panel of biomarkers of cerebral ischemia would have a major impact on the care of stroke patients by facilitating early management decisions and individualization of care. Biochemical surrogates of cerebral ischemia might also pl ... Full text Link to item Cite

Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice.

Journal Article J Neurotrauma · January 2010 There is emerging evidence to suggest that brain natriuretic peptide (BNP) is elevated after acute brain injury, and that it may play an adaptive role in recovery through augmentation of cerebral blood flow (CBF). Through a series of experiments, we tested ... Full text Open Access Link to item Cite

Statins in traumatic brain injury.

Journal Article Neurotherapeutics · January 2010 Traumatic brain injury (TBI) is a common cause of long-term neurological morbidity, with devastating personal and societal consequences. At present, no pharmacological intervention clearly improves outcomes, and therefore a compelling unmet clinical need r ... Full text Link to item Cite

Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage.

Journal Article J Neurosurg Anesthesiol · October 2009 Cognitive dysfunction, a significant complication after subarachnoid hemorrhage (SAH), affects up to 60% of survivors. We hypothesized that oral simvastatin would improve vestibulomotor function and reduce cognitive dysfunction after experimental SAH in th ... Full text Link to item Cite

S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage.

Journal Article Biomarkers · September 2009 Featured Publication OBJECTIVE: To determine the predictive value of S100b and brain natriuretic peptide (BNP) in order to determine accurately and quickly a discharge prognosis after primary supratentorial intracerebral haemorrhage (ICH). METHODS: After IRB approval and infor ... Full text Link to item Cite

The ultrasound brain helmet: Early human feasibility study of multiple simultaneous 3d scans of cerebral vasculature

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 19, 2009 We describe early stage experiments to test the feasibility of an ultrasound brain helmet to produce multiple simultaneous real-time 3D scans of the cerebral vasculature from temporal and suboccipital acoustic windows of the skull. The transducer hardware ... Full text Cite

Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery.

Journal Article Stroke · March 2009 Featured Publication BACKGROUND AND PURPOSE: Cognitive decline after cardiac surgery remains common and diminishes patients' quality of life. Based on experimental and clinical evidence, this study assessed the potential of intravenously administered lidocaine to reduce postop ... Full text Link to item Cite

The ultrasound brain helmet: feasibility study of multiple simultaneous 3D scans of cerebral vasculature.

Journal Article Ultrasound Med Biol · February 2009 Featured Publication We describe early stage experiments to test the feasibility of an ultrasound brain helmet to produce multiple simultaneous real-time three-dimensional (3D) scans of the cerebral vasculature from temporal and suboccipital acoustic windows of the skull. The ... Full text Link to item Cite

Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage.

Journal Article Stroke · February 2009 Featured Publication BACKGROUND AND PURPOSE: The purpose of the study was to evaluate the effect of APOE genotype and the feasibility of administering an apolipoprotein E-mimetic therapeutic to modify outcomes in a murine model of intracerebral hemorrhage. METHODS: Intracerebr ... Full text Link to item Cite

APOE genotype affects outcome in a murine model of sepsis: implications for a new treatment strategy.

Journal Article Anaesth Intensive Care · January 2009 Featured Publication In this study, we assessed whether apolipoprotein E (APOE) polymorphism affects inflammatory responses and mortality in the caecal ligation and puncture model of peritonitis. In addition, we determined the effects of APOE mimetic peptide administration in ... Full text Link to item Cite

Clinical usefulness of a biomarker-based diagnostic test for acute stroke: the Biomarker Rapid Assessment in Ischemic Injury (BRAIN) study.

Journal Article Stroke · January 2009 Featured Publication BACKGROUND AND PURPOSE: One of the significant limitations in the evaluation and management of patients with suspected acute cerebral ischemia is the absence of a widely available, rapid, and sensitive diagnostic test. The objective of the current study wa ... Full text Link to item Cite

Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans.

Journal Article J Stroke Cerebrovasc Dis · 2009 Featured Publication INTRODUCTION: To address the mechanisms by which apoE polymorphism affects functional outcome after intracerebral hemorrhage in humans, we tested the hypothesis that the presence of the APOE4 allele results in amplified inflammatory responses and increased ... Full text Link to item Cite

The ultrasound brain helmet for 3D transcranial Doppler imaging

Journal Article Proceedings - IEEE Ultrasonics Symposium · 2009 Transcranial Doppler imaging with contrast enhancement is a promising approach for visualizing a variety of cerebrovascular diseases requiring rapid treatment to minimize long-term effects. To address the time-sensitive nature of these diseases, we present ... Full text Cite

Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives.

Journal Article Exp Neurol · October 2008 Featured Publication Cognitive dysfunction is increasingly recognized as a significant long-term complication following subarachnoid hemorrhage (SAH), affecting up to 60% of survivors. We proposed to determine the incidence and explore potential mechanisms of cognitive dysfunc ... Full text Link to item Cite

270: C-reactive Protein as a Serum Biomarker in the Evaluation of Patients With Minor Head Injury and Normal Mental Status in the Emergency Department

Conference Annals of Emergency Medicine · October 2008 Full text Cite

Real-time 3-D contrast-enhanced transcranial ultrasound and aberration correction.

Journal Article Ultrasound Med Biol · September 2008 Featured Publication Contrast-enhanced (CE) transcranial ultrasound (US) and reconstructed 3-D transcranial ultrasound have shown advantages over traditional methods in a variety of cerebrovascular diseases. We present the results from a novel ultrasound technique, namely real ... Full text Link to item Cite

Management of post-subarachnoid hemorrhage vasospasm.

Journal Article Curr Atheroscler Rep · August 2008 Featured Publication Permanent neurologic injury and death remain common outcomes following aneurysmal subarachnoid hemorrhage. Although many sophisticated techniques are evolving for securing intracranial aneurysms to prevent rebleeding, progress is lagging in the management ... Full text Link to item Cite

The use of S100B as a biomarker in subarachnoid hemorrhage: clarity in its promise and limits.

Journal Article Crit Care Med · August 2008 Featured Publication Full text Link to item Cite

Challenges in enrollment of minority, pediatric, and geriatric patients in emergency and acute care clinical research.

Journal Article Ann Emerg Med · June 2008 Featured Publication STUDY OBJECTIVE: Emergency department (ED) -based clinical research has the potential to include patient populations that are typically underrepresented in clinical research. The objective of this study is to assess how emergency clinical care and research ... Full text Link to item Cite

Statins in acute brain injury: getting the cart before the horse.

Journal Article Neurocrit Care · 2008 Featured Publication Full text Link to item Cite

Preclinical models of intracerebral hemorrhage: a translational perspective.

Journal Article Neurocrit Care · 2008 Featured Publication Intracerebral hemorrhage (ICH) is a devastating and relatively common disease affecting as many as 50,000 people annually in the United States alone. ICH remains associated with poor outcome, and approximately 40-50% of afflicted patients will die within 3 ... Full text Link to item Cite

Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions.

Journal Article Pharmacogenomics · August 2007 Featured Publication The apolipoprotein E (apoE) polymorphism is emerging as a uniquely important genetic modifier that affects functional outcome from both acute and chronic neurological injuries. Recent attention has focused on common denominator mechanisms by which apoE mig ... Full text Cite

COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury.

Journal Article Journal of neurotrauma · July 2007 Featured Publication Traumatic brain injury (TBI) is a silent epidemic affecting approximately 1.4 million Americans annually, at an estimated annual cost of $60 billion in the United States alone. Despite an increased understanding of the pathophysiology of closed head injury ... Full text Cite

Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury.

Journal Article Exp Neurol · July 2007 Featured Publication The treatment of traumatic brain injury (TBI) remains limited, and aside from surgical hematoma evacuation, clinical management is largely supportive and directed toward management of cerebral edema and intracranial hypertension. Secondary neuronal injury ... Full text Link to item Cite

Corrigendum to "an apolipoprotein e-based therapeutic improves outcome and reduces alzheimer's disease pathology following closed head injury: Evidence of pharmacogenomic interaction". [Neuroscience 144 (2007) 1324-1333]^{{star, open}} (DOI:10.1016/j.neuroscience.2006.11.017)

Journal Article Neuroscience · May 11, 2007 Full text Cite

Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway.

Journal Article Neurol Res · April 2007 Featured Publication Recent evidence demonstrates that apolipoprotein E (apoE) influences the central nervous system (CNS) response to both acute and chronic injury. To address the mechanisms by which apoE influences neurological disease, we examined differential gene expressi ... Full text Link to item Cite

An apolipoprotein E-based therapeutic improves outcome and reduces Alzheimer's disease pathology following closed head injury: evidence of pharmacogenomic interaction.

Journal Article Neuroscience · February 23, 2007 Featured Publication Apolipoprotein E (apoE) modifies glial activation and the CNS inflammatory response in an isoform-specific manner. Peptides derived from the receptor-binding region of apoE have been demonstrated to maintain the functional activity of the intact protein, a ... Full text Link to item Cite

Real-time 3D contrast-enhanced transcranial ultrasound

Journal Article Proceedings - IEEE Ultrasonics Symposium · 2007 Contrast-enhanced (CE) transcranial ultrasound (US) and reconstructed 3D transcranial ultrasound have shown advantages over traditional methods in a variety of cerebrovascular diseases. We present the results from a novel ultrasound technique, namely real- ... Full text Cite

Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients.

Journal Article Crit Care Med · January 2007 Featured Publication OBJECTIVE: To test for an association between apolipoprotein E (APOE) genotypes and duration of intensive care unit delirium. DESIGN: Prospective, observational cohort study. SETTING: A 541-bed, community-based teaching hospital. PATIENTS: Fifty-three mech ... Full text Link to item Cite

The use of transcranial Doppler during tilt table testing in children presenting with syncope

Journal Article Journal for Vascular Ultrasound · January 1, 2007 Childhood syncope is common, and there are three categories of causes of syncope: noncardiovascular pseudosyncope, cardiovascular syncope, and neurally mediated syncope. Tilt table testing has become a valuable tool in the evaluation for the cause of synco ... Full text Cite

Phase aberration correction on a 3D ultrasound scanner using RF speckle from moving targets

Journal Article Proceedings - IEEE Ultrasonics Symposium · December 1, 2006 In 1992, Zhao et al. described a variation of the speckle-brightness algorithm for phase correction on moving targets [1, 2]. By subtracting two beam-summed consecutive interrogations of a region of interest, they were able to remove effects of reverberati ... Full text Cite

Can D-dimer levels identify patients at risk for early neurological deterioration in acute ischemic stroke?

Journal Article Nat Clin Pract Neurol · November 2006 Featured Publication Full text Link to item Cite

Risk of cerebral vasopasm after subarachnoid hemorrhage reduced by statin therapy: A multivariate analysis of an institutional experience.

Journal Article J Neurosurg · November 2006 Featured Publication OBJECT: Impairment of endothelial nitric oxide synthase (eNOS), endothelium-dependent relaxation, and cerebrovascular autoregulation all occur in vasospastic cerebral arteries following subarachnoid hemorrhage (SAH). The 3-hydroxy-3-methylglutaryl coenzyme ... Full text Link to item Cite

Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage.

Journal Article Neurosurg Focus · September 15, 2006 Featured Publication OBJECT: The efficacy of nimodipine was examined in a murine model of subarachnoid hemorrhage (SAH). End points included the diameter of the lumen of the middle cerebral artery (MCA) and behavioral outcome. An apolipoprotein E (apoE)-mimetic peptide, acetyl ... Full text Link to item Cite

Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis.

Journal Article The Journal of pharmacology and experimental therapeutics · September 2006 Featured Publication Apolipoprotein E (apoE), well known to play a role in lipid transport and cholesterol metabolism, also exerts anti-inflammatory and neuroprotective effects in the central nervous system. Recent clinical and genetic studies display an association between ap ... Cite

Central nervous system injury associated with cardiac surgery.

Journal Article Lancet · August 19, 2006 Featured Publication Millions of individuals with coronary artery or valvular heart disease have been given a new chance at life by heart surgery, but the potential for neurological injury is an Achilles heel. Technological advancements and innovations in surgical and anaesthe ... Full text Link to item Cite

Changing outcome from aneurysmal subarachnoid hemorrhage: another step closer.

Journal Article Anesthesiology · April 2006 Featured Publication Full text Link to item Cite

Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.

Journal Article Eur J Pharmacol · February 15, 2006 Featured Publication Closed head injury induces cerebral oxidative stress. The efficacy of a Mn (III) porphyrin catalytic antioxidant was assessed in a mouse closed head injury model. Mice were subjected to closed head injury and treated 15 min later with an i.v. bolus of vehi ... Full text Link to item Cite

A rat model of cerebral vasospasm resulting in chronic motor and neurocognitive deficits following experimental sah

Journal Article Journal of Neurosurgical Anesthesiology · January 1, 2006 Full text Cite

Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease.

Journal Article Acta neurologica Scandinavica. Supplementum · January 2006 Featured Publication The apolipoprotein E4 isoform (apoE4) was initially identified as a susceptibility gene for the development of Alzheimer's disease, and has also recently been associated with poor outcome after acute traumatic and ischemic brain injury. One mechanism by wh ... Full text Cite

A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage.

Journal Article Neurocrit Care · 2006 Featured Publication INTRODUCTION: Recent clinical observations demonstrate that the APOE4 genotype increases the development of delayed ischemic deficit and worsens prognosis following aneurysmal subarachnoid hemorrhage (SAH). In the current study, we use targeted replacement ... Full text Link to item Cite

Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage.

Journal Article Neurocrit Care · 2006 Featured Publication OBJECTIVES: Prophylactic treatment with antiepileptic drugs is common practice following subarachnoid hemorrhage (SAH) and traumatic brain injury. However, commonly used antiepileptic drugs have multiple drug interactions, require frequent monitoring of se ... Full text Link to item Cite

Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) surgery.

Journal Article Psychosom Med · 2006 Featured Publication OBJECTIVE: Although coronary artery bypass grafting (CABG) has been shown to improve quality of life and functional capacity for many patients, recent studies have demonstrated that a significant number of patients exhibit impairment in cognitive function ... Full text Link to item Cite

APOLIPOPROTEIN E4 POLYMORPHISM AS A GENETIC PREDISPOSITION TO DELIRIUM IN HUMANS.

Conference Critical Care Medicine · December 2005 Full text Cite

APOE polymorphism is associated with risk of severe sepsis in surgical patients.

Journal Article Crit Care Med · November 2005 Featured Publication OBJECTIVE: To test for an association between apolipoprotein E (APOE) genotypes and the occurrence of severe sepsis in an elective surgical cohort. DESIGN: Prospective, observational, single cohort study. SETTING: Sixteen-bed surgical intensive care unit ( ... Full text Link to item Cite

Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial.

Journal Article Stroke · September 2005 Featured Publication BACKGROUND AND PURPOSE: Cerebral vasospasm remains a major source of morbidity after aneurysmal subarachnoid hemorrhage (SAH). We demonstrate that simvastatin reduces serum markers of brain injury and attenuates vasospasm after SAH. METHODS: Patients with ... Full text Link to item Cite

871 Simvastatin Reduces Vasospasm after Aneurysmal Subarachnoid Hemorrhage: Results of a Pilot Randomized Clinical Trial.

Journal Article Neurosurgery · August 1, 2005 Full text Link to item Cite

Panel of biomarkers predicts stroke.

Journal Article Ann N Y Acad Sci · August 2005 Featured Publication Full text Link to item Cite

Intrathecal administration of a novel apoE-derived therapeutic peptide improves outcome following perinatal hypoxic-ischemic injury.

Journal Article Neurosci Lett · June 24, 2005 Perinatal hypoxic-ischemic brain injury remains a significant clinical problem for which there remains no adequate therapeutic intervention. Apolipoprotein E (apoE) is a 299 amino acid protein that has been demonstrated to modify functional recovery follow ... Full text Link to item Cite

Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass.

Journal Article J Cardiothorac Vasc Anesth · June 2005 OBJECTIVE: The purpose of this study was to determine if patients receiving statin therapy before coronary artery bypass grafting surgery would have less cognitive dysfunction after cardiopulmonary bypass as a consequence of a diminished inflammatory respo ... Full text Link to item Cite

A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury.

Journal Article Exp Neurol · March 2005 Featured Publication Although apolipoprotein E4 (APOE4) was initially identified as a susceptibility gene for the development of Alzheimer's disease, the presence of the APOE4 allele is also associated with poor outcome after acute brain injury. One mechanism by which apoE may ... Full text Link to item Cite

Simvastatin attenuates serum markers of vasospasm after aneurysmal subarachnoid hemorrhage

Conference STROKE · February 1, 2005 Link to item Cite

Galbraith Award: simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase.

Journal Article Clin Neurosurg · 2005 Featured Publication Link to item Cite

Questions and answers: Session I: The human experience of neuroprotection

Journal Article Annals of the New York Academy of Sciences · January 1, 2005 Full text Cite

Correlation of serum brain natriuretic peptide with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage.

Journal Article Neurosurgery · June 2004 OBJECTIVE: Serum brain natriuretic peptide (BNP) is elevated after subarachnoid hemorrhage (SAH), causes diuresis and natriuresis (cerebral salt wasting), and may exacerbate delayed ischemic neurological deficits. We examined the temporal relationship betw ... Cite

Panel of serum markers for rapid diagnosis of acute stroke - Response

Journal Article STROKE · June 1, 2004 Link to item Cite

Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity.

Journal Article Neurochem Int · January 2004 Apolipoprotein E (ApoE) deficiency has been shown to adversely affect outcome after transient cerebral ischemia and head trauma. Since oxidative stress contributes to these injuries, the ability of ApoE to reduce irreversible oxidative damage was studied i ... Full text Link to item Cite

Synthes Award for Resident Research in Spinal Cord & Spinal Column Injury: Statins for the treatment of neurological injury: a role beyond cholesterol lowering.

Journal Article Clin Neurosurg · 2004 Link to item Cite

Novel diagnostic test for acute stroke.

Journal Article Stroke · January 2004 Featured Publication BACKGROUND AND PURPOSE: The absence of a widely available and sensitive diagnostic test for acute cerebral ischemia remains a significant limitation in the diagnosis and management of stroke. The objective of this study was to examine the feasibility of de ... Full text Link to item Cite

An ApoE-based therapeutic improves outcome and reduces Alzheimer's disease pathology after head injury

Conference ANNALS OF NEUROLOGY · January 1, 2004 Link to item Cite

APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response.

Journal Article J Biol Chem · December 5, 2003 Featured Publication Human apolipoprotein E is the major apolipoprotein expressed in the brain and exists as three isoforms, designated E2, E3, and E4. Although evidence suggests that apolipoprotein E plays an important role in modifying systemic and brain inflammatory respons ... Full text Link to item Cite

Cerebral embolization during cardiac surgery: impact of aortic atheroma burden.

Other Br J Anaesth · November 2003 BACKGROUND: Aortic atheromatous disease is known to be associated with an increased risk of perioperative stroke in the setting of cardiac surgery. In this study, we sought to determine the relationship between cerebral microemboli and aortic atheroma burd ... Full text Link to item Cite

Early biomarkers of stroke.

Journal Article Clin Chem · October 2003 BACKGROUND: The diagnosis and management of acute ischemic stroke are limited by the lack of rapid diagnostic assays for use in an emergency setting. Computed tomography (CT) scanning is used to diagnose hemorrhagic stroke but is relatively ineffective (<3 ... Full text Link to item Cite

Elevation in serum brain natriuretic peptide correlates with cerebral vasospasm and hyponatremia after subarachnoid hemorrhage

Conference NEUROSURGERY · August 1, 2003 Link to item Cite

Statins improve neurological outcome, attenuate hippocampal neuronal degeneration, and decrease interleukin-6 expression after experimental traumatic brain injury

Conference NEUROSURGERY · August 1, 2003 Link to item Cite

Leukocytosis as an independent risk factor for cerebral vasospasm following aneurysmal subarachnoid hemorrhage.

Journal Article J Neurosurg · June 2003 Featured Publication OBJECT: The identification of patients at an increased risk for cerebral vasospasm after subarachnoid hemorrhage (SAH) may allow for more aggressive treatment and improved patient outcomes. Note, however, that blood clot size on admission remains the only ... Full text Link to item Cite

Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery.

Journal Article Stroke · February 2003 BACKGROUND AND PURPOSE: Although coronary artery bypass graft surgery (CABG) improves the quality of life and functional capacity for numerous patients, many also exhibit impairment in cognitive function immediately after surgery. Although the etiology of ... Full text Link to item Cite

Apolipoprotein E4 increases aortic atheroma burden in cardiac surgical patients.

Journal Article J Thorac Cardiovasc Surg · January 2003 Full text Link to item Cite

Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures.

Journal Article Neuroscience · 2003 Featured Publication Apolipoprotein E (apoE) is a 34-kD protein with multiple biological properties. Recent clinical and preclinical observations implicate a role for apoE in modifying the response of the brain to focal and global ischemia. One mechanism by which apoE might ex ... Full text Link to item Cite

Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation.

Journal Article J Radiat Res · December 2002 UNLABELLED: Apolipoprotein E (apoE) is a lipid binding protein that plays an important role in tissue repair following brain injury. In the present studies, we have investigated whether apoE affects the behavioral toxicity of high charge, high energy (HZE) ... Full text Link to item Cite

Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage.

Journal Article Stroke · December 2002 Featured Publication BACKGROUND AND PURPOSE: Endothelial nitric oxide synthase (eNOS) activity is decreased after subarachnoid hemorrhage (SAH). Simvastatin increases eNOS activity. We hypothesized that simvastatin would increase eNOS protein and ameliorate SAH-induced cerebra ... Full text Link to item Cite

Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage.

Journal Article Neurosurgery · November 2002 Featured Publication OBJECTIVE: Endothelial damage and intimal proliferation occur in vasospastic cerebral arteries after subarachnoid hemorrhage (SAH). In the peripheral vasculature, endothelial damage increases intimal matrix metalloproteinase-9 (MMP-9) and vascular endothel ... Full text Link to item Cite

Apolipoprotein E protects against NMDA excitotoxicity.

Journal Article Neurobiol Dis · October 2002 Featured Publication Preclinical and clinical evidence implicates a role for endogenous apolipoprotein E in modifying the response of the brain to focal and global ischemia. To investigate whether apoE modulates the neuronal response to glutamate excitotoxicity, we exposed pri ... Full text Link to item Cite

Toxicogenomics and human disease risk assessment

Journal Article Human and Ecological Risk Assessment · October 1, 2002 Complete sequencing of human and other genomes, availability of large-scale gene expression arrays with ever-increasing numbers of genes displayed, and steady improvements in protein expression technology can have a great impact on the field of toxicology. ... Full text Cite

Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase.

Journal Article Stroke · September 2002 BACKGROUND AND PURPOSE: Subarachnoid hemorrhage (SAH) increases production of vascular extracellular superoxide anion (*O2-). We examined whether overexpression of murine extracellular superoxide dismutase (EC-SOD) alters SAH-induced cerebral vasospasm, ox ... Full text Link to item Cite

Serum markers of neointimal proliferation effectively predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage

Journal Article NEUROSURGERY · August 1, 2002 Link to item Cite

Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates cerebral vasospasm after subarachnoid hemorrhage in the mouse via augmentation of endothelial nitric oxide synthase

Journal Article NEUROSURGERY · August 1, 2002 Link to item Cite

Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction.

Other Anesth Analg · July 2002 UNLABELLED: Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, ... Full text Link to item Cite

Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis.

Journal Article Neurol Res · July 2002 The transgenic mouse has been used to study subarachnoid hemorrhage (SAH) induced delayed cerebral vasospasm (DCV). Methodological parameters have not been analyzed to validate this model and associated neurological deficits have not been described. We int ... Full text Link to item Cite

Apolipoprotein E isoform mediated regulation of nitric oxide release.

Journal Article Free Radic Biol Med · June 1, 2002 Progressive dysfunction and death of neurons in Alzheimer's dementia is enhanced in patients carrying one or more APOE4 alleles who also display increased presence of oxidative stress markers. Modulation of oxidative stress is a nontraditional and physiolo ... Full text Link to item Cite

Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis?

Journal Article Anesth Analg · June 2002 UNLABELLED: Cardiopulmonary bypass (CPB) is associated with a spectrum of cerebral injuries. The molecular changes in the brain that might contribute to these injuries are not clearly known. We sought to determine whether the expression of apoptotic genes ... Full text Link to item Cite

Apolipoprotein E modulates the CNS response to injury

Journal Article Journal of Neurochemistry · June 2002 Apolipoprotein E (apoE) plays an important role in recovery from acute brain injury. One potential mechanism for this is that apoE down‐regulates glial activation and subsequent secretion of inflammatory mediators. Following a pneumatic impact to t ... Full text Cite

Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage in mice

Journal Article NEUROLOGY · April 9, 2002 Link to item Cite

The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery.

Journal Article Anesth Analg · February 2002 UNLABELLED: Neurocognitive decline is a continuing source of morbidity after cardiac surgery. Atrial fibrillation occurs often after cardiac surgery and has been linked to adverse neurologic events. We sought to determine whether postoperative atrial fibri ... Full text Link to item Cite

The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery.

Other Anesth Analg · January 2002 UNLABELLED: Neurocognitive dysfunction is a common complication after cardiac surgery. We evaluated in this prospective study the effect of rewarming rate on neurocognitive outcome after hypothermic cardiopulmonary bypass (CPB). After IRB approval and info ... Full text Link to item Cite

Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema.

Journal Article Ann Neurol · January 2002 Featured Publication Apolipoprotein E has been implicated in modifying neurological outcome after traumatic brain injury, although the mechanisms by which this occurs remain poorly defined. To investigate the role of endogenous apolipoprotein E following acute brain injury, no ... Full text Link to item Cite

Attenuation of cerebral vasospasm following subarachnoid hemorrhage in mice over-expressing extracellular superoxide dismutase

Journal Article STROKE · January 1, 2002 Link to item Cite

Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery.

Journal Article Stroke · December 1, 2001 BACKGROUND AND PURPOSE: The importance of perioperative cognitive decline has long been debated. We recently demonstrated a significant correlation between perioperative cognitive decline and long-term cognitive dysfunction. Despite this association, some ... Full text Link to item Cite

Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages.

Journal Article J Leukoc Biol · October 2001 Featured Publication Apolipoprotein E (ApoE) is a 34-kDa cholesterol transport protein that also possesses immunomodulatory properties. In this study, we demonstrate that ApoE initiates a signaling cascade in murine peritoneal macrophages that leads to increased production of ... Link to item Cite

Apolipoprotein E genotype differentially influences the proinflammatory and anti-inflammatory response to cardiopulmonary bypass.

Journal Article J Thorac Cardiovasc Surg · September 2001 Featured Publication Full text Link to item Cite

Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse.

Journal Article J Neurotrauma · June 2001 Oxidative stress is known to play an important role in the response of brain to traumatic insults. We tested the hypothesis that increased extracellular superoxide dismutase (EC-SOD) expression can reduce injury in a mouse model of closed head injury. Neur ... Full text Link to item Cite

Apolipoprotein E polymorphisms and age at first coronary artery bypass graft.

Journal Article Anesthesia and analgesia · April 2001 Apolipoprotein E (apoE) polymorphisms are heritable determinants of total and low-density lipoprotein cholesterol. The impact of apoE4 genotypes on the severity of atherosclerosis has been debated; however, recent studies have identified a correlation betw ... Cite

Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.

Journal Article J Neuroimmunol · March 1, 2001 Featured Publication Apolipoprotein E (apoE) is a 299 amino acid protein that is associated with risk of developing Alzheimer's Disease (AD) and outcome after acute brain injury. To investigate the possibility that apoE modulates glial activation we studied the effect of endog ... Full text Link to item Cite

Quiet time: a nursing intervention to promote sleep in neurocritical care units.

Journal Article Am J Crit Care · March 2001 BACKGROUND: Patients in intensive care units are often sleep deprived, yet little research exists on the impact of nursing care on promoting sleep. OBJECTIVES: To determine if implementing a "quiet time" protocol to reduce external environmental stimuli is ... Link to item Cite

Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides.

Journal Article Exp Neurol · January 2001 Featured Publication Apolipoprotein E plays an important role in recovery from acute brain injury and risk of developing Alzheimer's disease. We demonstrate that biologically relevant concentrations of apoE suppress microglial activation and release of TNFalpha and NO in a dos ... Full text Link to item Cite

Genetic predictors of perioperative neurological and cognitive injury and recovery

Journal Article Best Practice and Research: Clinical Anaesthesiology · January 1, 2001 In most investigations, genetic and environmental factors have been shown to interact in altering the progression of ageing related disease including stroke and cognitive decline. The perioperative period appears to be no different, with environmental (ope ... Full text Cite

Effects of extracellular superoxide dismutase on arterial vascular structural changes after acute subarachnoid hemorrhage in the mouse

Journal Article STROKE · January 1, 2001 Link to item Cite

813 Intracerebral Infusion of Human Recombinant Apolipoprotein E3 Reduces Global Ischemic Brain Injury in Apolipoprotein E Deficient Mice.

Journal Article Neurosurgery · August 1, 2000 Full text Link to item Cite

813 Intracerebral Infusion of Human Recombinant Apolipoprotein E3 Reduces Global Ischemic Brain Injury in Apolipoprotein E Deficient Mice.

Journal Article Neurosurgery · August 1, 2000 Full text Link to item Cite

Incidence of stroke in acute coronary syndromes without persistent ST- segment elevation

Journal Article Cardiology Review · July 24, 2000 Cite

A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia.

Journal Article Brain Res · June 16, 2000 Genetically engineered mice are increasingly important in stroke research. The strains on which these constructs are built are known to have inherent differential sensitivities to ischemic insults. This has been largely attributed to differences in vascula ... Full text Link to item Cite

Altered immune responses in apolipoprotein E-deficient mice.

Journal Article J Lipid Res · April 2000 Featured Publication Apolipoprotein E (apoE) is a 34 kDa glycosylated protein with multiple biological properties. In addition to its role in cholesterol transport, apoE has in vitro immunomodulatory properties. Recent data suggest that these immunomodulatory effects of apoE m ... Link to item Cite

Stroke in patients with acute coronary syndromes: incidence and outcomes in the platelet glycoprotein IIb/IIIa in unstable angina. Receptor suppression using integrilin therapy (PURSUIT) trial. The PURSUIT Investigators.

Journal Article Circulation · May 11, 1999 Featured Publication BACKGROUND: The incidence of stroke in patients with acute coronary syndromes has not been clearly defined because few trials in this patient population have been large enough to provide stable estimates of stroke rates. METHODS AND RESULTS: We studied the ... Full text Link to item Cite

Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse.

Journal Article Stroke · May 1999 BACKGROUND AND PURPOSE: Apolipoprotein E (apoE) has been found relevant in a variety of central nervous system disorders. This experiment examined the effect of endogenous murine apoE on selective neuronal necrosis resulting from a transient forebrain isch ... Full text Link to item Cite

Reliability of physical performance tests in four different randomized clinical trials.

Journal Article Arch Phys Med Rehabil · May 1999 OBJECTIVES: (1) To assess the test-retest reliability of physical performance tests in subject groups with different levels of impairment and disability, and (2) to assess the stability of these tests over different time intervals. DESIGN: Test-retest, rep ... Full text Link to item Cite

Survival and outcome after endotracheal intubation for acute stroke.

Journal Article Neurology · April 22, 1999 OBJECTIVE: To assess survival and functional outcome in patients endotracheally intubated after ischemic stroke (IS) or spontaneous intracerebral hemorrhage (ICH). BACKGROUND: Endotracheal intubation is both a necessary life support intervention and a meas ... Full text Link to item Cite

Characterization of a recovery global cerebral ischemia model in the mouse.

Journal Article J Neurosci Methods · April 1, 1999 Transgenic/knockout murine variants allow roles of specific proteins to be studied in cerebral ischemia. Because of the size of mice, however, study of prolonged recovery from global ischemia has been limited. This project characterized an adaptation of th ... Full text Link to item Cite

Apolipoprotein E polymorphism and age of presentation for coronary revascularization

Journal Article ANESTHESIA AND ANALGESIA · April 1, 1999 Link to item Cite

Genetic predictors of perioperative neurologic and neuropsychological injury and recovery

Journal Article Seminars in Cardiothoracic and Vascular Anesthesia · January 1, 1999 Central nervous system (CNS) dysfunction after cardiopulmonary bypass represents a continuum from coma and focal stroke to cognitive deficits after surgery. Despite the marked increase in investigation of neurologic and neurocognitive deficits after cardia ... Full text Cite

Apolipoprotein E: An expanding role in the neurobiology of disease

Journal Article Alzheimer's Reports · December 1, 1998 Cite

APOE3 and APOE4 binding to macrophages triggers inositol (1,4,5-) triphosphate-mediated increases in intracellular calcium

Journal Article FASEB Journal · December 1, 1998 Apolipoprotein E (apoE) is a 34 kDa protein that mediates binding of lipopro teins to the LDL and LRP receptors- Apart from maintaining plasma cholesterol homeostasis, apoE may participate in mobilization and redistribution of lipids during normal developm ... Cite

Regional CBF in apolipoprotein E-deficient and wild type mice during focal cerebral ischemia.

Journal Article Neuroreport · August 3, 1998 Apolipoprotein E-(apoE) deficient mice exhibit hypercholesterolemia, accelerated atherosclerosis and increased infarct size after middle cerebral artery occlusion (MCAO). This study examined whether worsened ischemic outcome is attributable to effects of a ... Full text Link to item Cite

Apolipoprotein E and the CNS response to injury.

Journal Article J Cereb Blood Flow Metab · May 1998 Featured Publication Apolipoprotein E (apoE) is a multifunctional protein with an expanding role in the neurobiology of disease. Although originally described in the context of cholesterol metabolism, interest in the neurobiology of apoE has intensified following the associati ... Full text Link to item Cite

Acute visual loss and other disorders of the eyes.

Journal Article Neurol Clin · May 1998 This article outlines neuro-ophthalmic findings and diseases which may present in an emergency setting. The abnormal optic disc, visual loss, double-vision and disorders of gaze, skew deviation, and the neuro-ophthalmology of vascular lesions, intracerebra ... Full text Link to item Cite

Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice.

Journal Article J Cereb Blood Flow Metab · April 1998 Featured Publication Apolipoprotein E (apoE), a 34-KD glycosylated lipid-binding protein, is expressed as three common isoforms in humans (E2, E3, or E4). Clinical evidence suggests that the apoE genotype (APOE) may be a risk factor for poor outcome after acute central nervous ... Full text Link to item Cite

Survival, functional outcome, and quality of life following endotracheal intubation for acute stroke

Journal Article NEUROLOGY · April 1, 1998 Link to item Cite

Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production.

Journal Article Neuroreport · March 9, 1998 Featured Publication The human apolipoprotein (apo) E4 isoform is associated with an increased risk for Alzheimer's disease (AD) and poor prognosis after acute CNS injury. Addition of human apoE inhibits murine microglial activation in culture, suggesting that microglia might ... Full text Link to item Cite

Serum markers of cerebral ischemia.

Journal Article J Stroke Cerebrovasc Dis · 1998 Rapid diagnosis and management of stroke patients is becoming increasingly important with the emergence of new interventional strategies for acute cerebral ischemia. A biochemical surrogate of cerebral ischemia, rapidly detectable in the serum before radio ... Full text Link to item Cite

Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia.

Journal Article J Cereb Blood Flow Metab · July 1997 Featured Publication Recent evidence suggests that apolipoprotein E (ApoE) plays a role in neurologic disease. This experiment compared the neurologic and histologic outcome of ApoE-deficient mutant and wild-type mice subjected to a 60- or 90-minute episode of middle cerebral ... Full text Link to item Cite

Apolipoprotein E suppresses glial cell secretion of TNF alpha.

Journal Article J Neuroimmunol · June 1997 Featured Publication Apolipoprotein E (apoE) is a 299 amino acid protein with multiple biological functions. Initially described in the context of cholesterol metabolism, apoE also has immunomodulatory properties and recent evidence has implicated a role for apoE in neurologic ... Full text Link to item Cite

The syndrome of frontal lobe epilepsy: characteristics and surgical management.

Journal Article Neurology · April 1995 We reviewed the historical features, preoperative diagnostic evaluation, operative procedure, and surgical outcome in 16 patients with refractory frontal lobe epilepsy. Clinical expression of the epilepsy varied widely, particularly with respect to seizure ... Full text Link to item Cite

Re: MRI in Guillain-barré syndrome

Journal Article Neurology · January 1, 1995 Full text Cite

The syndrome of frontal lobe epilepsy : characteristics and surgical management

Journal Article Neurology · 1995 Cite

Geniculocalcarine hyperintensities on brain magnetic resonance imaging associated with visual hallucinations in the elderly.

Journal Article Psychiatry Res · December 1994 Magnetic resonance scans of five geriatric patients presenting with formed visual hallucinations in the absence of other psychopathology were compared with those of 12 healthy elderly subjects for the presence and extent of subcortical and periventricular ... Full text Link to item Cite

Magnetic resonance imaging of the cauda equina in Guillain-Barré syndrome.

Journal Article Neurology · July 1994 We report three patients (two children and one adult) with Guillain-Barré syndrome and magnetic resonance imaging evidence of gadolinium enhancement of the cauda equina and lumbar nerve roots. All three patients exhibited symmetric ascending paralysis and ... Full text Link to item Cite

Hyperthermia-induced enhancement of melphalan activity against a melphalan-resistant human rhabdomyosarcoma xenograft.

Journal Article Radiat Res · February 1992 The effects of regional hyperthermia (42 degrees C for 70 min) on the antitumor activity of melphalan were examined in athymic mice bearing melphalan-resistant human rhabdomyosarcoma (TE-671 MR) xenografts growing in the right hind limb, and results were c ... Link to item Cite

Effects of glutathione or polyamine depletion on in vivo thermosensitization.

Journal Article Int J Hyperthermia · 1992 Investigations with the melphalan-sensitive and -resistant human rhabdomyosarcoma xenografts TE-671 and TE-671 MR were performed to examine the effect of glutathione and polyamine modulation on thermosensitivity. Regimens of intraperitoneally injected and ... Full text Link to item Cite

Enhancement of melphalan-induced gastrointestinal toxicity in mice treated with regional hyperthermia and BSO-mediated glutathione depletion.

Journal Article Int J Hyperthermia · 1992 Both hyperthermia and glutathione depletion have been shown to increase the antineoplastic activity of melphalan. Investigations were carried out to define the toxicity and activity of melphalan given in conjunction with local (right hind limb) hyperthermi ... Full text Link to item Cite

Therapeutic analysis of melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR.

Journal Article Cancer Res · August 1, 1991 Investigations with the melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR were carried out to identify patterns of cross-resistance and collateral sensitivity and to define the mechanism(s) mediating melphalan resistance. TE-671 MR was cross-r ... Link to item Cite

In vivo stereological assessment of human cerebellar volume: effects of gender and age.

Journal Article AJNR Am J Neuroradiol · 1991 Intermediate T2-weighted MR images and a systematic sampling stereological method were used in 37 normal volunteers, 24 to 79 years old, to assess the effects of age and sex on cerebellar volume. Female subjects (n = 21) had significantly smaller cerebella ... Link to item Cite