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Ines Batinic-Haberle

Professor Emeritus of Radiation Oncology
Radiation Oncology
Box 3839 Med Ctr, Durham, NC 27710
Duke Hospital South, Orange Zone, Room 5317, 200 Trent Drive, Durham, NC 27710

Selected Publications


Intracarotid Infusion of Redox-Active Manganese Porphyrin, MnTnBuOE-2-PyP5+, following Reperfusion Improves Long-Term, 28-Day Post-Stroke Outcomes in Rats.

Journal Article Antioxidants (Basel) · October 13, 2023 Endovascular mechanical thrombectomy, combined with a tissue plasminogen activator (t-PA), is efficacious as a standard care for qualifying ischemic stroke patients. However, > 50% of thrombectomy patients still have poor outcomes. Manganese porphyrins, co ... Full text Link to item Cite

The Redox-Active Manganese(III) Porphyrin, MnTnBuOE-2-PyP5+, Impairs the Migration and Invasion of Non-Small Cell Lung Cancer Cells, Either Alone or Combined with Cisplatin.

Journal Article Cancers (Basel) · July 27, 2023 Manganese(III) porphyrin MnTnBuOE-2-PyP5+ (MnBuOE, BMX-001) is a third-generation redox-active cationic substituted pyridylporphyrin-based drug with a good safety/toxicity profile that has been studied in several types of cancer. It is currently in four ph ... Full text Link to item Cite

Mn(III) Porphyrin, MnTnBuOE-2-PyP5+, Commonly Known as a Mimic of Superoxide Dismutase Enzyme, Protects Cardiomyocytes from Hypoxia/Reoxygenation Induced Injury via Reducing Oxidative Stress.

Journal Article Int J Mol Sci · March 24, 2023 Myocardial ischemia-reperfusion injury (I/R) causes damage to cardiomyocytes through oxidative stress and apoptosis. We investigated the cardioprotective effects of MnTnBuOE-2-PyP5+ (BMX-001), a superoxide dismutase mimic, in an in vitro model of I/R injur ... Full text Link to item Cite

Effect of the nature of the chelated metal on the photodynamic activity of metalloporphyrins.

Journal Article Free Radic Res · 2023 Coordination of metal ions by the tetrapyrrolic macrocyclic ring of porphyrin-based photosensitizers (PSs) affects their photophysical properties and consequently, their photodynamic activity. Diamagnetic metals increase the singlet oxygen quantum yield wh ... Full text Open Access Link to item Cite

MnTnHex-2-PyP5+ Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells.

Journal Article Antioxidants (Basel) · November 7, 2022 The manganese(III) porphyrin MnTnHex-2-PyP5+ (MnTnHex) is a potent superoxide dismutase mimic and modulator of redox-based transcriptional activity that has been studied in the context of different human disease models, including cancer. Nevertheless, for ... Full text Link to item Cite

Manganese Porphyrin Promotes Post Cardiac Arrest Recovery in Mice and Rats.

Journal Article Biology (Basel) · June 24, 2022 Introduction Cardiac arrest (CA) and resuscitation induces global cerebral ischemia and reperfusion, causing neurologic deficits or death. Manganese porphyrins, superoxide dismutase mimics, are reportedly able to effectively reduce ischemic injury in brain ... Full text Link to item Cite

Cardioprotective effects of redox regulator MnTnBuOE-2-PyP 5+ in myocardial ischemia/reperfusion injury

Journal Article FASEB journal : official publication of the Federation of American Societies for Experimental Biology · May 1, 2022 BACKGROUND: Myocardial infarction is a leading cause of death worldwide and occurs due to decrease or complete blockage of coronary blood flow. Re-establishment of blood flow after a brief period of ischemia is accompanied by exacerbation of the cardiomyoc ... Full text Cite

Rotenone-Induced 4-HNE Aggresome Formation and Degradation in HL-1 Cardiomyocytes: Role of Autophagy Flux.

Journal Article Int J Mol Sci · April 23, 2022 Reactive oxygen species (ROS) cause oxidative stress by generating reactive aldehydes known as 4-hydroxynonenal (4-HNE). 4-HNE modifies protein via covalent adduction; however, little is known about the degradation mechanism of 4-HNE-adducted proteins. Aut ... Full text Link to item Cite

Antioxidant and Pro-Oxidant Actions of Mn Porphyrin-Based Therapeutics

Conference Free Radical Biology and Medicine · February 2022 Full text Cite

2021 SFRBM DISCOVERY AWARD LECTURE

Conference Free Radical Biology and Medicine · February 2022 Full text Cite

A Redox-active Mn Porphyrin, MnTnBuOE-2-PyP5+, Synergizes with Carboplatin in Treatment of Chemoresistant Ovarian Cell Line.

Journal Article Oxid Med Cell Longev · 2022 We have employed a redox-active MnP (MnTnBuOE-2-PyP5+, Mn(III) meso-tetrakis (N-n-butoxyethylpyridinium-2-yl) porphyrin) frequently identified as superoxide dismutase mimic or BMX-001, to explore the redox status of normal ovarian cell in relation to two o ... Full text Link to item Cite

Ascorbate-dependent and ascorbate-independent Mn porphyrin cytotoxicity: anticancer activity of Mn porphyrin-based SOD mimics through ascorbate-dependent and -independent routes.

Journal Article Redox Rep · December 2021 OBJECTIVE: The aim of this study was to investigate how modifications at the periphery of the porphyrin ring affect the anticancer activity of Mn porphyrins (MnPs)-based SOD mimics. METHODS: Six compounds: MnTE-2-PyP with a short ethyl chain on the pyridyl ... Full text Link to item Cite

MnTnHex-2-PyP5+, Coupled to Radiation, Suppresses Metastasis of 4T1 and MDA-MB-231 Breast Cancer via AKT/Snail/EMT Pathways.

Journal Article Antioxidants (Basel) · November 5, 2021 Tumor migration and invasion induced by the epithelial-to-mesenchymal transition (EMT) are prerequisites for metastasis. Here, we investigated the inhibitory effect of a mimic of superoxide dismutase (SOD), cationic Mn(III) ortho-substituted N-n-hexylpyrid ... Full text Link to item Cite

Ortho Isomeric Mn(III) N-Alkyl- and Alkoxyalkylpyridylporphyrins-Enhancers of Hyaluronan Degradation Induced by Ascorbate and Cupric Ions.

Journal Article Int J Mol Sci · August 10, 2021 High levels of hyaluronic acid (HA) in tumors correlate with poor outcomes with several types of cancers due to HA-driven support of adhesion, migration and proliferation of cells. In this study we explored how to enhance the degradation of HA into low-mol ... Full text Link to item Cite

Evaluation of the compounds commonly known as superoxide dismutase and catalase mimics in cellular models.

Journal Article J Inorg Biochem · June 2021 Oxidative stress that results from an imbalance between the concentrations of reactive species (RS) and antioxidant defenses is associated with many pathologies. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase are among the key enzym ... Full text Open Access Link to item Cite

Manganese Porphyrin and Radiotherapy Improves Local Tumor Response and Overall Survival in Orthotopic Murine Mammary Carcinoma Models.

Journal Article Radiat Res · February 1, 2021 Novel synthetic compounds, known as manganese porphyrins (MnPs), have been designed to shift the redox status of both normal cells and cancer cells. When MnPs are coupled with cancer therapies, such as radiation, they have been shown to sensitize tumor cel ... Full text Link to item Cite

H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways.

Journal Article Oxid Med Cell Longev · 2021 Mn(III) ortho-N-alkyl- and N-alkoxyalkyl porphyrins (MnPs) were initially developed as superoxide dismutase (SOD) mimics. These compounds were later shown to react with numerous reactive species (such as ONOO-, H2O2, H2S, CO3 •-, ascorbate, and GSH). Moreo ... Full text Open Access Link to item Cite

Intracarotid Infusion of Redox-Active Manganese Porphyrin, MnTnBuOE-2-PyP5+, following Reperfusion Improves Long-Term, 28-Day Post-Stroke Outcomes in Rats.

Journal Article Antioxidants (Basel) · October 13, 2023 Endovascular mechanical thrombectomy, combined with a tissue plasminogen activator (t-PA), is efficacious as a standard care for qualifying ischemic stroke patients. However, > 50% of thrombectomy patients still have poor outcomes. Manganese porphyrins, co ... Full text Link to item Cite

The Redox-Active Manganese(III) Porphyrin, MnTnBuOE-2-PyP5+, Impairs the Migration and Invasion of Non-Small Cell Lung Cancer Cells, Either Alone or Combined with Cisplatin.

Journal Article Cancers (Basel) · July 27, 2023 Manganese(III) porphyrin MnTnBuOE-2-PyP5+ (MnBuOE, BMX-001) is a third-generation redox-active cationic substituted pyridylporphyrin-based drug with a good safety/toxicity profile that has been studied in several types of cancer. It is currently in four ph ... Full text Link to item Cite

Mn(III) Porphyrin, MnTnBuOE-2-PyP5+, Commonly Known as a Mimic of Superoxide Dismutase Enzyme, Protects Cardiomyocytes from Hypoxia/Reoxygenation Induced Injury via Reducing Oxidative Stress.

Journal Article Int J Mol Sci · March 24, 2023 Myocardial ischemia-reperfusion injury (I/R) causes damage to cardiomyocytes through oxidative stress and apoptosis. We investigated the cardioprotective effects of MnTnBuOE-2-PyP5+ (BMX-001), a superoxide dismutase mimic, in an in vitro model of I/R injur ... Full text Link to item Cite

Effect of the nature of the chelated metal on the photodynamic activity of metalloporphyrins.

Journal Article Free Radic Res · 2023 Coordination of metal ions by the tetrapyrrolic macrocyclic ring of porphyrin-based photosensitizers (PSs) affects their photophysical properties and consequently, their photodynamic activity. Diamagnetic metals increase the singlet oxygen quantum yield wh ... Full text Open Access Link to item Cite

MnTnHex-2-PyP5+ Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells.

Journal Article Antioxidants (Basel) · November 7, 2022 The manganese(III) porphyrin MnTnHex-2-PyP5+ (MnTnHex) is a potent superoxide dismutase mimic and modulator of redox-based transcriptional activity that has been studied in the context of different human disease models, including cancer. Nevertheless, for ... Full text Link to item Cite

Manganese Porphyrin Promotes Post Cardiac Arrest Recovery in Mice and Rats.

Journal Article Biology (Basel) · June 24, 2022 Introduction Cardiac arrest (CA) and resuscitation induces global cerebral ischemia and reperfusion, causing neurologic deficits or death. Manganese porphyrins, superoxide dismutase mimics, are reportedly able to effectively reduce ischemic injury in brain ... Full text Link to item Cite

Cardioprotective effects of redox regulator MnTnBuOE-2-PyP 5+ in myocardial ischemia/reperfusion injury

Journal Article FASEB journal : official publication of the Federation of American Societies for Experimental Biology · May 1, 2022 BACKGROUND: Myocardial infarction is a leading cause of death worldwide and occurs due to decrease or complete blockage of coronary blood flow. Re-establishment of blood flow after a brief period of ischemia is accompanied by exacerbation of the cardiomyoc ... Full text Cite

Rotenone-Induced 4-HNE Aggresome Formation and Degradation in HL-1 Cardiomyocytes: Role of Autophagy Flux.

Journal Article Int J Mol Sci · April 23, 2022 Reactive oxygen species (ROS) cause oxidative stress by generating reactive aldehydes known as 4-hydroxynonenal (4-HNE). 4-HNE modifies protein via covalent adduction; however, little is known about the degradation mechanism of 4-HNE-adducted proteins. Aut ... Full text Link to item Cite

Antioxidant and Pro-Oxidant Actions of Mn Porphyrin-Based Therapeutics

Conference Free Radical Biology and Medicine · February 2022 Full text Cite

2021 SFRBM DISCOVERY AWARD LECTURE

Conference Free Radical Biology and Medicine · February 2022 Full text Cite

A Redox-active Mn Porphyrin, MnTnBuOE-2-PyP5+, Synergizes with Carboplatin in Treatment of Chemoresistant Ovarian Cell Line.

Journal Article Oxid Med Cell Longev · 2022 We have employed a redox-active MnP (MnTnBuOE-2-PyP5+, Mn(III) meso-tetrakis (N-n-butoxyethylpyridinium-2-yl) porphyrin) frequently identified as superoxide dismutase mimic or BMX-001, to explore the redox status of normal ovarian cell in relation to two o ... Full text Link to item Cite

Ascorbate-dependent and ascorbate-independent Mn porphyrin cytotoxicity: anticancer activity of Mn porphyrin-based SOD mimics through ascorbate-dependent and -independent routes.

Journal Article Redox Rep · December 2021 OBJECTIVE: The aim of this study was to investigate how modifications at the periphery of the porphyrin ring affect the anticancer activity of Mn porphyrins (MnPs)-based SOD mimics. METHODS: Six compounds: MnTE-2-PyP with a short ethyl chain on the pyridyl ... Full text Link to item Cite

MnTnHex-2-PyP5+, Coupled to Radiation, Suppresses Metastasis of 4T1 and MDA-MB-231 Breast Cancer via AKT/Snail/EMT Pathways.

Journal Article Antioxidants (Basel) · November 5, 2021 Tumor migration and invasion induced by the epithelial-to-mesenchymal transition (EMT) are prerequisites for metastasis. Here, we investigated the inhibitory effect of a mimic of superoxide dismutase (SOD), cationic Mn(III) ortho-substituted N-n-hexylpyrid ... Full text Link to item Cite

Ortho Isomeric Mn(III) N-Alkyl- and Alkoxyalkylpyridylporphyrins-Enhancers of Hyaluronan Degradation Induced by Ascorbate and Cupric Ions.

Journal Article Int J Mol Sci · August 10, 2021 High levels of hyaluronic acid (HA) in tumors correlate with poor outcomes with several types of cancers due to HA-driven support of adhesion, migration and proliferation of cells. In this study we explored how to enhance the degradation of HA into low-mol ... Full text Link to item Cite

Evaluation of the compounds commonly known as superoxide dismutase and catalase mimics in cellular models.

Journal Article J Inorg Biochem · June 2021 Oxidative stress that results from an imbalance between the concentrations of reactive species (RS) and antioxidant defenses is associated with many pathologies. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase are among the key enzym ... Full text Open Access Link to item Cite

Manganese Porphyrin and Radiotherapy Improves Local Tumor Response and Overall Survival in Orthotopic Murine Mammary Carcinoma Models.

Journal Article Radiat Res · February 1, 2021 Novel synthetic compounds, known as manganese porphyrins (MnPs), have been designed to shift the redox status of both normal cells and cancer cells. When MnPs are coupled with cancer therapies, such as radiation, they have been shown to sensitize tumor cel ... Full text Link to item Cite

H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways.

Journal Article Oxid Med Cell Longev · 2021 Mn(III) ortho-N-alkyl- and N-alkoxyalkyl porphyrins (MnPs) were initially developed as superoxide dismutase (SOD) mimics. These compounds were later shown to react with numerous reactive species (such as ONOO-, H2O2, H2S, CO3 •-, ascorbate, and GSH). Moreo ... Full text Open Access Link to item Cite

MnTnBuOE-2-PyP5+ Ascorbate in the Treatment of Ovarian Cancer

Conference Free Radical Biology and Medicine · November 2020 Full text Cite

Antibacterial Activity of Synthetic Cationic Iron Porphyrins.

Journal Article Antioxidants (Basel) · October 10, 2020 Widespread antibiotic resistance demands new strategies for fighting infections. Porphyrin-based compounds were long ago introduced as photosensitizers for photodynamic therapy, but light-independent antimicrobial activity of such compounds has not been sy ... Full text Link to item Cite

Mn porphyrins as a novel treatment targeting sickle cell NOXs to reverse and prevent acute vaso-occlusion in vivo.

Journal Article Blood Adv · June 9, 2020 In sickle cell disease (SCD), adhesion of sickle red blood cells (SSRBCs) and activated leukocytes in inflamed venules affects blood rheology, causing vaso-occlusive manifestations and vital reduction in microvascular blood flow. Recently, we found that NA ... Full text Open Access Link to item Cite

Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP4+, in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H2O)MnTnHex-2-PyP5+.

Journal Article Antioxidants (Basel) · June 1, 2020 Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, (H2O)MnTnHex-2-PyP5+ (MnHex) carrying long hexyl chains, is a lipophilic mimic of superoxide dismutase (SOD) and a redox-active drug candidate. MnHex crosses the blood-brain barrier, and improved ne ... Full text Open Access Link to item Cite

Effects of Manganese Porphyrins on Cellular Sulfur Metabolism.

Journal Article Molecules · February 22, 2020 Manganese porphyrins (MnPs), MnTE-2-PyP5+, MnTnHex-2-PyP5+ and MnTnBuOE-2-PyP5+, are superoxide dismutase (SOD) mimetics and form a redox cycle between O2 and reductants, including ascorbic acid, ultimately producing hydrogen peroxide (H2O2). We previously ... Full text Link to item Cite

Redox-Active Drug, MnTE-2-PyP5+, Prevents and Treats Cardiac Arrhythmias Preserving Heart Contractile Function.

Journal Article Oxid Med Cell Longev · 2020 BACKGROUND: Cardiomyopathies remain among the leading causes of death worldwide, despite all efforts and important advances in the development of cardiovascular therapeutics, demonstrating the need for new solutions. Herein, we describe the effects of the ... Full text Link to item Cite

25 years of development of Mn porphyrins - from mimics of superoxide dismutase enzymes to thiol signaling to clinical trials: The story of our life in the USA

Chapter · January 1, 2020 We have developed Mn porphyrins (MnPs) initially as mimics of superoxide dismutase (SOD) enzymes based on structure-activity relationships. Several cationic Mn porphyrins, being substituted with cationic ortho N-alkyl- or alkoxyalkylpyridyl groups in meso ... Full text Cite

Manganese Porphyrin-Based SOD Mimetics Produce Polysulfides from Hydrogen Sulfide.

Journal Article Antioxidants (Basel) · December 12, 2019 Manganese-centered porphyrins (MnPs), MnTE-2-PyP5+ (MnTE), MnTnHex-2-PyP5+ (MnTnHex), and MnTnBuOE-2-PyP5+ (MnTnBuOE) have received considerable attention because of their ability to serve as superoxide dismutase (SOD) mimetics thereby producing hydrogen p ... Full text Link to item Cite

25 years of development of Mn porphyrins-from mimics of superoxide dismutase enzymes to thiol signaling to clinical trials: The story of our life in the USA

Journal Article Journal of Porphyrins and Phthalocyanines · November 1, 2019 We have developed Mn porphyrins (MnPs) initially as mimics of superoxide dismutase (SOD) enzymes based on structure-activity relationships. Several cationic Mn porphyrins, being substituted with cationic ortho N-alkyl-or alkoxyalkylpyridyl groups in meso p ... Full text Cite

The SOD Mimic MnTnHex-2-PyP5+ Reduces the Viability and Migration of 786-O Human Renal Cancer Cells.

Journal Article Antioxidants (Basel) · October 17, 2019 Clear-cell renal carcinoma (ccRCC) is the most common type of renal cancer. The importance of oxidative stress in the context of this disease has been described, although there is only little information concerning the role of superoxide dismutase (SOD) en ... Full text Link to item Cite

Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion.

Journal Article Redox Biol · July 2019 In sickle cell disease (SCD), recurrent painful vasoocclusive crisis are likely caused by repeated episodes of hypoxia and reoxygenation. The sickle erythrocyte (SSRBC) adhesion plays an active role in vasoocclusion. However, the effect of prolonged reoxyg ... Full text Open Access Link to item Cite

Thiol regulation by Mn porphyrins, commonly known as SOD mimics.

Journal Article Redox Biol · July 2019 Superoxide dismutases play an important role in human health and disease. Three decades of effort have gone into synthesizing SOD mimics for clinical use. The result is the Mn porphyrins which have SOD-like activity. Several clinical trials are underway to ... Full text Link to item Cite

UVB-induced inactivation of manganese-containing superoxide dismutase promotes mitophagy via ROS-mediated mTORC2 pathway activation.

Journal Article J Biol Chem · April 26, 2019 Mitochondria are major sites of energy metabolism that influence numerous cellular events, including immunity and cancer development. Previously, we reported that the mitochondrion-specific antioxidant enzyme, manganese-containing superoxide dismutase (MnS ... Full text Link to item Cite

The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells.

Journal Article Redox Biol · January 2019 Manganese(III) porphyrins (MnPs) are superoxide dismutase (SOD) mimics with demonstrated beneficial effects in cancer treatment in combination with chemo- and radiotherapy regimens. Despite the ongoing clinical trials, little is known about the effect of M ... Full text Open Access Link to item Cite

MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management.

Journal Article Redox Biol · January 2019 Negative Pressure Wound Therapy (NPWT), a widely used modality in the management of surgical and trauma wounds, offers clear benefits over conventional wound healing strategies. Despite the wide-ranging effects ascribed to NPWT, the precise molecular mecha ... Full text Open Access Link to item Cite

Utilizing Superoxide Dismutase Mimetics to Enhance Radiation Therapy Response While Protecting Normal Tissues.

Journal Article Semin Radiat Oncol · January 2019 Symptomatic normal tissue injury is a common side effect following definitive therapeutic radiation and chemotherapy treatment for a variety of malignancies. These cancer therapy related toxicities may occur acutely during treatment resulting in reduced or ... Full text Link to item Cite

Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury.

Journal Article Antioxid Redox Signal · December 1, 2018 SIGNIFICANCE: After approximatelty three decades of research, two Mn(III) porphyrins (MnPs), MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have progressed to five clinical trials. In parallel, another similarly potent metal-based supero ... Full text Link to item Cite

Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate.

Journal Article Antioxid Redox Signal · November 1, 2018 AIMS: We aim here to demonstrate that radiation (RT) enhances tumor sensitization by only those Mn complexes that are redox active and cycle with ascorbate (Asc), thereby producing H2O2 and utilizing it subsequently in protein S-glutathionylation in a glut ... Full text Link to item Cite

Mn porphyrin/ascorbate sensitizes serous epithelial ovarian cancer to chemotherapy

Conference Free Radical Biology and Medicine · November 2018 Full text Cite

Manganese superoxide dismutase regulates mTORC2 mediated UVB-induced mitophagy

Conference Free Radical Biology and Medicine · November 2018 Full text Cite

Porphyrin-Based SOD Mimic MnTnBu OE -2-PyP5+ Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis.

Journal Article J Am Heart Assoc · October 16, 2018 Background Aortic valve sclerosis ( AVS c), the early asymptomatic presentation of calcific aortic valve (AV) disease, affects 25% to 30% of patients aged >65 years. In vitro and ex vivo experiments with antioxidant strategies and antagonists of osteogenic ... Full text Link to item Cite

Manganese porphyrin redox state in endothelial cells: Resonance Raman studies and implications for antioxidant protection towards peroxynitrite.

Journal Article Free Radic Biol Med · October 2018 Cationic manganese(III) ortho N-substituted pyridylporphyrins (MnP) act as efficient antioxidants catalyzing superoxide dismutation and accelerating peroxynitrite reduction. Importantly, MnP can reach mitochondria offering protection against reactive speci ... Full text Link to item Cite

INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice.

Journal Article Stem Cell Reports · June 5, 2018 Brain neurogenesis is severely impaired following exposure to ionizing radiation (IR). We and others have shown that the expression of the tumor suppressor gene p16INK4a is increased in tissues exposed to IR and thus hypothesized that its expression could ... Full text Link to item Cite

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning.

Journal Article Redox Biol · June 2018 Developmental synapse pruning refines burgeoning connectomes. The basic mechanisms of mitochondrial reactive oxygen species (ROS) production suggest they select inactive synapses for pruning: whether they do so is unknown. To begin to unravel whether mitoc ... Full text Open Access Link to item Cite

Beneficial impact of a manganese(III) porphyrin in cancer cell migration

Conference Free Radical Biology and Medicine · May 2018 Full text Cite

ROS regulate developmental and pathological denervation in vivo

Conference Free Radical Biology and Medicine · May 2018 Full text Cite

Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation.

Journal Article Antioxidants (Basel) · March 7, 2018 Radiation injury to the lung is the result of acute and chronic free radical formation, and there are currently few effective means of mitigating such injury. Studies in rodents indicate that superoxide dismutase mimetics may be effective in this regard; h ... Full text Link to item Cite

Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells.

Journal Article PLoS One · 2018 We investigated the cytogenetic and gene expression responses of peripheral blood cells of non-human primates (NHP, Macaca mulatta) that were whole-thorax irradiated with a single dose of 10 Gy. In this model, partial irradiation of NHPs in the thoracic re ... Full text Link to item Cite

Sublethal Photodynamic Treatment Does Not Lead to Development of Resistance.

Journal Article Front Microbiol · 2018 A promising new alternative approach for eradication of antibiotic-resistant strains is to expose microbes to photosensitizers, which upon illumination generate reactive oxygen species. Among the requirements for a potent, medically applicable photosensiti ... Full text Open Access Link to item Cite

Cationic amphiphilic Zn-porphyrin with high antifungal photodynamic potency.

Journal Article Photochem Photobiol Sci · November 8, 2017 Photodynamic therapy (PDT) is a promising alternative approach particularly attractive for treatment of localized fungal infections. It is based on compounds, photosensitizers (PSs), which when excited with visible light, generate reactive species that ult ... Full text Open Access Link to item Cite

Mechanism of the Antitumor and Radiosensitizing Effects of a Manganese Porphyrin, MnHex-2-PyP.

Journal Article Antioxidants & redox signaling · November 2017 AimsCationic manganese (Mn)-substituted N-pyridylporphyrin-based potent mimics of the family of superoxide dismutases (SODs) protect normal tissues from injury related to ionizing radiation (IR) by reducing levels of reactive oxygen and nitrogen s ... Full text Cite

Protection Of Neurocognitive Function During Cranial Irradiation Of Brain Tumors

Conference Free Radical Biology and Medicine · November 2017 Full text Cite

Differences in Reperfusion-Induced Mitochondrial Oxidative Stress and Cell Death Between Hippocampal CA1 and CA3 Subfields Are Due to the Mitochondrial Thioredoxin System.

Journal Article Antioxid Redox Signal · September 20, 2017 AIMS: The susceptibility of CA1 over CA3 to damage from cerebral ischemia may be related to the differences in reactive oxygen species (ROS) production/removal between the two hippocampal subfields. We aimed to measure CA1/CA3 differences in net ROS produc ... Full text Link to item Cite

A novel redox regulator, MnTnBuOE-2-PyP5+, enhances normal hematopoietic stem/progenitor cell function.

Journal Article Redox Biol · August 2017 The signaling of reactive oxygen species (ROS) is essential for the maintenance of normal cellular function. However, whether and how ROS regulate stem cells are unclear. Here, we demonstrate that, in transgenic mice expressing the human manganese superoxi ... Full text Link to item Cite

CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5.

Journal Article Redox Biol · August 2017 Although radiation therapy can be effective against cancer, potential damage to normal tissues limits the amount that can be safely administered. In central nervous system (CNS), radiation damage to normal tissues is presented, in part, as suppressed hippo ... Full text Link to item Cite

Potential for a novel manganese porphyrin compound as adjuvant canine lymphoma therapy.

Journal Article Cancer Chemother Pharmacol · August 2017 PURPOSE: Manganese porphyrins are redox-active drugs and superoxide dismutase mimics, which have been shown to chemosensitize lymphoma, a cancer which frequently occurs in dogs. This study aimed to identify critical information regarding the pharmacokineti ... Full text Link to item Cite

Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin.

Journal Article Radiat Res · July 2017 Normal tissue damage after head and neck radiotherapy involves a continuum of pathologic events to the mucosa, tongue and salivary glands. We examined the radioprotective effects of MnBuOE, a redox-active manganese porphyrin, at three stages of normal tiss ... Full text Link to item Cite

Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues.

Journal Article J Inorg Biochem · April 2017 We disclose here the studies that preceded and guided the preparation of the metal-based, redox-active therapeutic Mn(III) meso-tetrakis(N-n-butoxyethylpyridyl)porphyrin, MnTnBuOE-2-PyP5+ (BMX-001), which is currently in Phase I/II Clinical Trials at Duke ... Full text Open Access Link to item Cite

Optimizing Zn porphyrin-based photosensitizers for efficient antibacterial photodynamic therapy.

Journal Article Photodiagnosis Photodyn Ther · March 2017 INTRODUCTION: Efficient photodynamic inactivation of microbes requires highly efficient photosensitizers which kill microbial cells, but spare host tissues. One way to achieve such selectivity is to use photosensitizers that are rapidly taken up by microbe ... Full text Link to item Cite

Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics.

Journal Article Hypoxia (Auckl) · 2017 The "Hypoxia Nantes 2016" organized its second conference dedicated to the field of hypoxia research. This conference focused on "the role of hypoxia under physiological conditions as well as in cancer" and took place in Nantes, France, in October 6-7, 201 ... Full text Open Access Link to item Cite

Post-illumination cellular effects of photodynamic treatment.

Journal Article PLoS One · 2017 Increased interest in clinical application of photodynamic therapy (PDT) in various medical fields poses a demand for better understanding of processes triggered by photo-treatment. Most of the work on PDT performed so far has focused on the immediate effe ... Full text Link to item Cite

A Novel Redox Based Therapy Targets the Malignant Cellular Redox State

Conference Free Radical Biology and Medicine · November 2016 Full text Cite

Important cellular targets for antimicrobial photodynamic therapy.

Journal Article Appl Microbiol Biotechnol · September 2016 The persistent problem of antibiotic resistance has created a strong demand for new methods for therapy and disinfection. Photodynamic inactivation (PDI) of microbes has demonstrated promising results for eradication of antibiotic-resistant strains. PDI is ... Full text Link to item Cite

Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier.

Journal Article Environ Mol Mutagen · June 2016 Combinations of radiotherapy (RT) and chemotherapy have shown efficacy toward brain tumors. However, therapy-induced oxidative stress can damage normal brain tissue, resulting in both progressive neurocognitive loss and diminished quality of life. We have ... Full text Link to item Cite

Opinion on Schmidt et al.

Journal Article Antioxid Redox Signal · March 20, 2016 Full text Link to item Cite

Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.

Journal Article Stem Cell Rev Rep · February 2016 Glioblastoma multiforme is the most malignant tumor of the brain and is challenging to treat due to its highly invasive nature and heterogeneity. Malignant brain tumor displays high metabolic activity which perturbs its redox environment and in turn transl ... Full text Link to item Cite

Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.

Journal Article Free Radic Biol Med · February 2016 Cardiovascular complications are major side effects of many anticancer drugs. Accumulated evidence indicates that oxidative stress in mitochondria plays an important role in cardiac injury, but how mitochondrial redox mechanisms are involved in cardiac dys ... Full text Link to item Cite

Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints.

Journal Article Food Chem Toxicol · January 2016 Ochratoxin A (OTA) is a well-known nephrotoxic and potential carcinogenic agent but no consensus about the molecular mechanisms underlying its deleterious effects has been reached yet. The aim of this study is to integrate several endpoints concerning OTA- ... Full text Link to item Cite

Anticancer therapeutic potential of Mn porphyrin/ascorbate system.

Journal Article Free Radic Biol Med · December 2015 Ascorbate (Asc) as a single agent suppressed growth of several tumor cell lines in a mouse model. It has been tested in a Phase I Clinical Trial on pancreatic cancer patients where it exhibited no toxicity to normal tissue yet was of only marginal efficacy ... Full text Link to item Cite

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2015 PURPOSE: To test the effects of a novel Mn porphyrin oxidative stress modifier, Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin (MnBuOE), for its radioprotective and radiosensitizing properties in normal tissue versus tumor, respectively. ME ... Full text Open Access Link to item Cite

A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.

Journal Article Free Radic Biol Med · September 2015 Because of the increased insight into the biological role of hydrogen peroxide (H2O2) under physiological and pathological conditions and the role it presumably plays in the action of natural and synthetic redox-active drugs, there is a need to accurately ... Full text Link to item Cite

An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.

Journal Article Redox Biol · August 2015 Most of the SOD mimics thus far developed belong to the classes of Mn-(MnPs) and Fe porphyrins(FePs), Mn(III) salens, Mn(II) cyclic polyamines and metal salts. Due to their remarkable stability we have predominantly explored Mn porphyrins, aiming initially ... Full text Link to item Cite

Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells.

Journal Article Free Radic Biol Med · June 2015 The manganese porphyrin, manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin (MnTE-2-PyP(5+)), acts as a pro-oxidant in the presence of intracellular H2O2. Mitochondria are the most prominent source of intracellular ROS and important regulators ... Full text Link to item Cite

Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.

Journal Article Mol Cancer Ther · January 2015 Cranial irradiation is a standard therapy for primary and metastatic brain tumors. A major drawback of radiotherapy (RT), however, is long-term cognitive loss that affects quality of life. Radiation-induced oxidative stress in normal brain tissue is though ... Full text Link to item Cite

Amphiphilic cationic Zn-porphyrins with high photodynamic antimicrobial activity.

Journal Article Future Microbiol · 2015 AIM: Photodynamic inactivation of microbes can efficiently eradicate antibiotic-resistant strains. Systematic structural modification was used to investigate how porphyrin-based photosensitizers (PSs) could be designed for improved antibacterial activity. ... Full text Link to item Cite

Mn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathways.

Journal Article Free Radic Res · December 2014 Herein we have demonstrated that both superoxide dismutase (SOD) mimic, cationic Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin (MnTnHex-2-PyP(5+)), and non-SOD mimic, anionic Mn(III) meso-tetrakis(4-carboxylatophenyl)porphyrin (MnTBAP(3-)), prot ... Full text Link to item Cite

Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.

Journal Article Inorg Chem · November 3, 2014 Our goal herein has been to gain further insight into the parameters which control porphyrin therapeutic potential. Mn porphyrins (MnTnOct-2-PyP(5+), MnTnHexOE-2-PyP(5+), MnTE-2-PyPhP(5+), and MnTPhE-2-PyP(5+)) that bear the same positive charge and same n ... Full text Link to item Cite

Mitigation of Radiation-Mediated Suppression of Hippocampal Neurogenesis

Journal Article Free Radical Biology and Medicine · November 2014 Full text Cite

Rational Design of New Cationic Mn Porphyrins and Evaluation of Their Therapeutic Potential

Journal Article Free Radical Biology and Medicine · November 2014 Full text Cite

The Role of Ascorbate in Therapeutic Actions of Cationic Mn Porphyrin-Based SOD Mimics

Journal Article Free Radical Biology and Medicine · November 2014 Full text Cite

Electrochemistry of redox-active Mn porphyrin-based SOD mimic MnTnBuOE-2-PyP5+ - study of redox species involved in ROS/RNS scavenging

Journal Article ADMET and DMPK · September 1, 2014 Manganese ortho tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin, MnTnBuOE-2-PyP5+, is a third-generation redox-active compound currently undergoing preclinical exploration. This work is intended to complement the already extensive research of its chemica ... Full text Cite

Redox potential determines the reaction mechanism of HNO donors with Mn and Fe porphyrins: defining the better traps.

Journal Article Inorg Chem · July 21, 2014 Azanone ((1)HNO, nitroxyl) is a highly reactive molecule with interesting chemical and biological properties. Like nitric oxide (NO), its main biologically related targets are oxygen, thiols, and metalloproteins, particularly heme proteins. As HNO dimerize ... Full text Link to item Cite

Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment.

Journal Article Free Radic Biol Med · July 2014 Doxorubicin (DOX), one of the most effective anticancer drugs, is known to generate progressive cardiac damage, which is due, in part, to DOX-induced reactive oxygen species (ROS). The elevated ROS often induce oxidative protein modifications that result i ... Full text Link to item Cite

Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin.

Journal Article Antioxid Redox Signal · May 20, 2014 AIMS: Inside-out signaling occurs when changes in organellar activity lead to alterations in cell signaling that culminate at the cell surface. Mitochondria are vital signaling platforms in cells that participate in radiation-induced inside-out signaling. ... Full text Link to item Cite

Complex chemistry and biology of redox-active compounds, commonly known as SOD mimics, affect their therapeutic effects.

Journal Article Antioxid Redox Signal · May 20, 2014 This Editorial has the intention to stress the complex chemistry and biology of redox-active compounds, regarded as SOD mimics. It further aims to caution the researchers of the importance of being up-to-date with the present knowledge on such compounds an ... Full text Link to item Cite

Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia.

Journal Article Antioxid Redox Signal · May 20, 2014 AIMS: The goal of this study was to use two manganese (Mn)-based superoxide dismutase (SOD) mimics to test the hypothesis that reactive oxygen species contribute to both acute and long-term outcomes in a galactose-1P uridylyltransferase (GALT)-null Drosoph ... Full text Link to item Cite

SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways.

Journal Article Antioxid Redox Signal · May 20, 2014 SIGNIFICANCE: Superoxide dismutase (SOD) enzymes are indispensable and ubiquitous antioxidant defenses maintaining the steady-state levels of O2·(-); no wonder, thus, that their mimics are remarkably efficacious in essentially any animal model of oxidative ... Full text Link to item Cite

Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.

Journal Article Free Radic Biol Med · March 2014 Resistance to therapy-mediated apoptosis in inflammatory breast cancer, an aggressive and distinct subtype of breast cancer, was recently attributed to increased superoxide dismutase (SOD) expression, glutathione (GSH) content, and decreased accumulation o ... Full text Link to item Cite

Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+).

Journal Article Redox Biol · 2014 With the goal to enhance the distribution of cationic Mn porphyrins within mitochondria, the lipophilic Mn(III)meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) has been synthesized and tested in several different model of diseases, where ... Full text Link to item Cite

Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP5+

Journal Article Redox Biology · January 1, 2014 With the goal to enhance the distribution of cationic Mn porphyrins within mitochondria, the lipophilic Mn(III)meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP5+ has been synthesized and tested in several different model of diseases, where i ... Full text Cite

Targeting mitochondria by Zn(II)N-alkylpyridylporphyrins: the impact of compound sub-mitochondrial partition on cell respiration and overall photodynamic efficacy.

Journal Article PLoS One · 2014 Mitochondria play a key role in aerobic ATP production and redox control. They harness crucial metabolic pathways and control cell death mechanisms, properties that make these organelles essential for survival of most eukaryotic cells. Cancer cells have al ... Full text Link to item Cite

Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae.

Journal Article Redox Biol · 2014 Cationic Mn(III) porphyrin complexes based on MnTM-2-PyP are among the most promising superoxide dismutase (SOD) mimicking compounds being considered as potential anti-inflammatory drugs. We studied four of these active compounds in the yeast Saccharomyces ... Full text Link to item Cite

Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(II) N-alkylpyridylporphyrins.

Journal Article J Biol Chem · December 20, 2013 Tetra-cationic Zn(II) meso-tetrakis(N-alkylpyridinium-2 (or -3 or -4)-yl)porphyrins (ZnPs) with progressively increased lipophilicity were synthesized to investigate how the tri-dimensional shape and lipophilicity of the photosensitizer (PS) affect cellula ... Full text Link to item Cite

The complex mechanistic aspects of redox-active compounds, commonly regarded as SOD mimics

Journal Article BioInorganic Reaction Mechanisms · December 1, 2013 This review aims to clarify (1) what is a true mimic of superoxide dismutase family of enzymes, SOD; and (2) whether such compound could act as SOD mimic in a complex biological milieu. Several groups of compounds (metalloporphyrins, metallocorroles, Mn bi ... Full text Cite

Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells.

Journal Article Antioxid Redox Signal · December 1, 2013 AIMS: The immune system is critical for protection against infections and cancer, but requires scrupulous regulation to limit self-reactivity and autoimmunity. Our group has utilized a manganese porphyrin catalytic antioxidant (MnTE-2-PyP(5+), MnP) as a po ... Full text Link to item Cite

Critical Oxidative Stress Causes Early Fetal Brain Injury Resulting in Cerebral Palsy

Journal Article Free Radical Biology and Medicine · November 2013 Full text Cite

Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells.

Journal Article Mutagenesis · November 2013 Acrylamide (AA) is a well-known industrial chemical classified as a probable human carcinogen. Benign and malignant tumours at different sites, including the mammary gland, have been reported in rodents exposed to AA. This xenobiotic is also formed in many ... Full text Link to item Cite

Acid-base and electrochemical properties of manganese meso(ortho- and meta-N-ethylpyridyl)porphyrins: voltammetric and chronocoulometric study of protolytic and redox equilibria.

Journal Article Dalton Trans · October 1, 2013 Growing interest in redox-active compounds as therapeutics for oxidative stress-related diseases led to the design of metalloporphyrins as some of the most potent functional SOD-mimics. Herein we report a detailed electrochemical study of the protolytic an ... Full text Link to item Cite

The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies.

Journal Article Free Radic Biol Med · July 2013 Chemoresistance due to oxidative stress resistance or upregulation of Bcl-2 contributes to poor outcome in the treatment of hematological malignancies. In this study, we utilize the copper-chelator drug ATN-224 (choline tetrathiomolybdate) to induce cell d ... Full text Link to item Cite

Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.

Journal Article Inorg Chem · May 20, 2013 The different biological behavior of cationic Fe and Mn pyridylporphyrins in Escherichia coli and mouse studies prompted us to revisit and compare their chemistry. For that purpose, the series of ortho and meta isomers of Fe(III) meso-tetrakis-N-alkylpyrid ... Full text Open Access Link to item Cite

Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.

Journal Article Free Radic Biol Med · May 2013 The cationic, ortho Mn(III) N-alkylpyridylporphyrins (alkyl=ethyl, E, and n-hexyl, nHex) MnTE-2-PyP(5+) (AEOL10113, FBC-007) and MnTnHex-2-PyP(5+) have proven efficacious in numerous in vivo animal models of diseases having oxidative stress in common. The ... Full text Open Access Link to item Cite

Abstract 5552: Manganese porphyrins in combination with ascorbate act as pro-oxidants and mediate caspase-independent cancer cell death.

Conference Cancer Research · April 15, 2013 AbstractResistance to therapy-mediated apoptosis in inflammatory breast cancer (IBC), an aggressive and distinct subtype of breast cancer was recently attributed to increased antioxidant expression (superoxi ... Full text Cite

Intracellular targeting and pharmacological activity of the superoxide dismutase mimics MnTE-2-PyP5+ and MnTnHex-2-PyP5+ regulated by their porphyrin ring substituents.

Journal Article Inorg Chem · April 15, 2013 Manganese porphyrin-based drugs are potent mimics of the enzyme superoxide dismutase. They exert remarkable efficacy in disease models and are entering clinical trials. Two lead compounds, MnTE-2-PyP(5+) and MnTnHex-2-PyP(5+), have similar catalytic rates, ... Full text Link to item Cite

The administration of renoprotective agents extends warm ischemia in a rat model.

Journal Article J Endourol · March 2013 BACKGROUND AND PURPOSE: Extended warm ischemia time during partial nephrectomy leads to considerable renal injury. Using a rat model of renal ischemia, we examined the ability of a unique renoprotective cocktail to ameliorate warm ischemia-reperfusion inju ... Full text Link to item Cite

Radiation induces aerobic glycolysis through reactive oxygen species.

Journal Article Radiother Oncol · March 2013 BACKGROUND AND PURPOSE: Although radiation induced reoxygenation has been thought to increase radiosensitivity, we have shown that its associated oxidative stress can have radioprotective effects, including stabilization of the transcription factor hypoxia ... Full text Link to item Cite

Thermal stability of the prototypical Mn porphyrin-based superoxide dismutase mimic and potent oxidative-stress redox modulator Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride, MnTE-2-PyP(5+).

Journal Article J Pharm Biomed Anal · January 25, 2013 Cationic Mn porphyrins are among the most potent catalytic antioxidants and/or cellular redox modulators. Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride (MnTE-2-PyPCl(5)) is the Mn porphyrin most studied in vivo and has successfully rescue ... Full text Link to item Cite

Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum.

Journal Article Redox Biol · 2013 Radiation proctitis, an inflammation and damage to the lower part of colon, is a common adverse event of the radiotherapy of tumors in the abdominal and pelvic region (colon, prostate, cervical). Several Mn(III) porphyrin-based superoxide dismutase mimics ... Full text Link to item Cite

Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.

Journal Article Med Princ Pract · 2013 Based on aqueous redox chemistry and simple in vivo models of oxidative stress, Escherichia coli and Saccharomyces cerevisiae, the cationic Mn(III) N-substituted pyridylporphyrins (MnPs) have been identified as the most potent cellular redox modulators wit ... Full text Open Access Link to item Cite

Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: detection, oxidative damage and catalytic removal by Mn-porphyrins.

Journal Article Arch Biochem Biophys · January 1, 2013 Peroxynitrite (ONOO(-)) formation in mitochondria may be favored due to the constant supply of superoxide radical (O(2)(∙-)) by the electron transport chain plus the facile diffusion of nitric oxide ((∙)NO) to this organelle. Herein, a model system of subm ... Full text Link to item Cite

Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications.

Journal Article Redox Biol · 2013 Mn(III) N-alkylpyridylporphyrins (MnPs) have demonstrated protection in various conditions where increased production of reactive oxygen/reactive nitrogen species (ROS/RNS), is a key pathological factors. MnPs can produce both pro-oxidative and antioxidati ... Full text Link to item Cite

Mn porphyrins as novel molecular magnetic resonance imaging contrast agents.

Journal Article J Endourol · November 2012 BACKGROUND AND PURPOSE: In this study, we investigated the potential of a new class of therapeutic Mn porphyrins as molecular MRI probes for prostate cancer imaging. Two compounds of different bioavailibility were investigated: Mn(III) meso-tetrakis(N-ethy ... Full text Link to item Cite

Detailed mechanism of the autoxidation of N-hydroxyurea catalyzed by a superoxide dismutase mimic Mn(III) porphyrin: formation of the nitrosylated Mn(II) porphyrin as an intermediate.

Journal Article Dalton Trans · October 14, 2012 The in vitro autoxidation of N-hydroxyurea (HU) is catalyzed by Mn(III)TTEG-2-PyP(5+), a synthetic water soluble Mn(III) porphyrin which is also a potent mimic of the enzyme superoxide dismutase. The detailed mechanism of the reaction is deduced from kinet ... Full text Link to item Cite

XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells.

Journal Article Mol Cancer Ther · July 2012 We recently identified superoxide dismutase (SOD) overexpression and decreased induction of reactive oxygen species (ROS)-mediated apoptosis in models of inflammatory breast cancer (IBC) cells with acquired therapeutic resistance. This population of cells ... Full text Link to item Cite

A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.

Journal Article Free Radic Biol Med · May 1, 2012 The Mn porphyrins of k(cat)(O(2)(.-)) as high as that of a superoxide dismutase enzyme and of optimized lipophilicity have already been synthesized. Their exceptional in vivo potency is at least in part due to their ability to mimic the site and location o ... Full text Open Access Link to item Cite

Manganese superoxide dismutase, MnSOD and its mimics.

Journal Article Biochim Biophys Acta · May 2012 Increased understanding of the role of mitochondria under physiological and pathological conditions parallels increased exploration of synthetic and natural compounds able to mimic MnSOD - endogenous mitochondrial antioxidant defense essential for the exis ... Full text Link to item Cite

Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation.

Journal Article Oncogene · April 26, 2012 Manganese superoxide dismutase is a nuclear encoded primary antioxidant enzyme localized exclusively in the mitochondrial matrix. Genotoxic agents, such as ultraviolet (UV) radiation, generates oxidative stress and cause mitochondrial DNA (mtDNA) damage. T ... Full text Link to item Cite

Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants.

Journal Article J Neurosci · April 18, 2012 The early antecedents of cerebral palsy (CP) are unknown but are suspected to be due to hypoxia-ischemia (H-I). In our rabbit model of CP, the MRI biomarker, apparent diffusion coefficient (ADC) on diffusion-weighted imaging, predicted which fetuses will d ... Full text Link to item Cite

Manganese porphyrin, MnTE-2-PyP5+, Acts as a pro-oxidant to potentiate glucocorticoid-induced apoptosis in lymphoma cells.

Journal Article Free Radic Biol Med · April 15, 2012 Using current chemotherapy protocols, over 55% of lymphoma patients fail treatment. Novel agents are needed to improve lymphoma survival. The manganese porphyrin, MnTE-2-PyP(5+), augments glucocorticoid-induced apoptosis in WEHI7.2 murine thymic lymphoma c ... Full text Link to item Cite

ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells.

Journal Article Breast Cancer Res Treat · February 2012 Overexpression of epidermal growth factor receptors (ErbB) is frequently seen in inflammatory breast cancer (IBC). Treatment with ErbB1/2-targeting agents (lapatinib) mediates tumor apoptosis by downregulating ErbB1/2 phosphorylation and downstream surviva ... Full text Link to item Cite

Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.

Journal Article Amino Acids · January 2012 The most efficacious Mn(III) porphyrinic (MnPs) scavengers of reactive species have positive charges close to the Mn site, whereby they afford thermodynamic and electrostatic facilitation for the reaction with negatively charged species such as O (2) (•-) ... Full text Link to item Cite

Protein damage by photo-activated Zn(II) N-alkylpyridylporphyrins.

Journal Article Amino Acids · January 2012 Destruction of unwanted cells and tissues in photodynamic therapy (PDT) is achieved by a combination of light, oxygen, and light-sensitive molecules. The advantages of PDT compared to other traditional treatment modalities, and the shortcomings of the curr ... Full text Link to item Cite

Amelioration of renal ischemia-reperfusion injury with a novel protective cocktail.

Journal Article J Urol · December 2011 PURPOSE: Extended warm ischemia during partial nephrectomy can lead to considerable renal injury. Using a rat model of renal ischemia we examined the ability of a unique renoprotective cocktail to ameliorate warm ischemia-reperfusion injury. MATERIALS AND ... Full text Link to item Cite

Mn-porphyrins as novel molecular magnetic resonance imaging contrast agents.

Journal Article J Endourol · November 3, 2011 BACKGROUND AND PURPOSE: In this study, we investigated the potential of a new class of therapeutic Mn porphyrins as molecular MRI probes for prostate cancer imaging. Two compounds of different bioavailibility were investigated: Mn(III) meso-tetrakis(N-ethy ... Full text Link to item Cite

Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.

Journal Article Free Radic Res · November 2011 Due to the ability to easily accept and donate electrons Mn(III)N-alkylpyridylporphyrins (MnPs) can dismute O(2)(·-), reduce peroxynitrite, but also generate reactive species and behave as pro-oxidants if conditions favour such action. Herein two ortho iso ... Full text Link to item Cite

Lipophilic Mn Porphyrins in the Treatment of Brain Tumors

Conference Free Radical Biology and Medicine · November 2011 Full text Cite

Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats.

Journal Article Exp Eye Res · October 2011 This study aimed to clarify the possible therapeutic benefit of preferential nitric oxide synthase (NOS) inhibition and catalytic antioxidant Mn (III) meso-tetrakis (N-n-hexylpyridinium-2-yl) porphyrin (MnTnHex-2-PyP(5+)) treatment in a rat model of elevat ... Full text Link to item Cite

Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage.

Journal Article J Pharmacol Exp Ther · September 2011 Intracerebroventricular treatment with redox-regulating Mn(III) N-hexylpyridylporphyrin (MnPorphyrin) is remarkably efficacious in experimental central nervous system (CNS) injury. Clinical development has been arrested because of poor blood-brain barrier ... Full text Open Access Link to item Cite

Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics.

Journal Article Free Radic Biol Med · September 1, 2011 Oxidative stress, a redox imbalance between the endogenous reactive species and antioxidant systems, is common to numerous pathological conditions such as cancer, central nervous system injuries, radiation injury, diabetes etc. Therefore, compounds able to ... Full text Link to item Cite

Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression.

Journal Article Free Radic Biol Med · July 1, 2011 Our recent studies showed that total body irradiation (TBI) induces long-term bone marrow (BM) suppression in part by induction of hematopoietic stem cell (HSC) senescence through reactive oxygen species (ROS). In this study, we examined if Mn(III) meso-te ... Full text Link to item Cite

Vitamin C and neoplastic diseases

Journal Article Farmaceutski Glasnik · June 22, 2011 Ascorbic acid, the infamous antioxidant and cofactor of many enzymes, is present in the cell in millimolar, while in plasma and extracellular fluid in micromolar concentrations, as monovalent ascorbate anion. The highest levels of ascorbate are found in th ... Cite

NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability.

Journal Article Mutagenesis · May 2011 Ionising radiation (IR) is a known carcinogen and poses a significant risk to the haematopoietic system for the development of leukaemia in part by induction of genomic instability. Induction of chronic oxidative stress has been assumed to play an importan ... Full text Link to item Cite

A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon.

Journal Article Anticancer Agents Med Chem · May 1, 2011 Cationic Mn(III) N-alkylpyridyl (MnTalkyl-2(or 3)-PyP(5+)) and N, N'-dialkylimidazolylporphyrins (MnTDalkyl-2-ImP(5+)) have been regarded as the most powerful SOD mimics/peroxynitrite scavengers - i. e. antioxidants. The ethyl-, MnTE-2-PyP(5+) (AEOL10113), ... Full text Link to item Cite

Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.

Journal Article Dalton Trans · April 28, 2011 Cationic Mn(III) N-alkylpyridylporphyrins (MnPs) are potent SOD mimics and peroxynitrite scavengers and diminish oxidative stress in a variety of animal models of central nervous system (CNS) injuries, cancer, radiation, diabetes, etc. Recently, properties ... Full text Open Access Link to item Cite

Response to Rosenthal et al.

Journal Article Antioxidants and Redox Signaling · March 15, 2011 Full text Cite

2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.

Journal Article PLoS One · February 4, 2011 BACKGROUND: Gliomas frequently contain mutations in the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase (IDH1) or the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2). Several different amino acid substitutions recur at either IDH1 R1 ... Full text Link to item Cite

Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors.

Journal Article Anticancer Agents Med Chem · February 2011 Despite intensive efforts to improve multimodal treatment of brain tumor, survival remains limited. Current therapy consists of a combination of surgery, irradiation and chemotherapy with predisposition to long-term complications. Identifying novel targete ... Full text Link to item Cite

Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site.

Journal Article Free Radic Res · February 2011 In the cell Mn porphyrins (MnPs) likely couple with cellular reductants which results in a drop of total charge from 5+ to 4+ and dramatically increases their lipophilicity by up to three orders of magnitude depending upon the length of alkylpyridyl chains ... Full text Link to item Cite

The potential of Zn(II) N-alkylpyridylporphyrins for anticancer therapy.

Journal Article Anticancer Agents Med Chem · February 2011 Reactive oxygen species (ROS) are considered to be a main cause for cancer development, but they can also be used for cancer eradication. Because of this dual nature of ROS action, both antioxidant and prooxidant therapeutic agents have been developed and ... Full text Link to item Cite

Vitamin C and neoplastic diseases

Journal Article Farmaceutski Glasnik · 2011 Ascorbic acid, the infamous antioxidant and cofactor of many enzymes, is present in the cell in millimolar, while in plasma and extracellular fluid in micromolar concentrations, as monovalent ascorbate anion. The highest levels of ascorbate are found in th ... Cite

Acid-base and electrochemical properties of manganese meso(ortho- and meta-N-ethylpyridyl)porphyrins: potentiometric, spectrophotometric and spectroelectrochemical study of protolytic and redox equilibria.

Journal Article Dalton Trans · December 28, 2010 The difference in electrostatics and reduction potentials between manganese ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin (MnTE-2-PyP) and manganese meta-tetrakis(N-ethylpyridinium-3-yl)porphyrin (MnTE-3-PyP) is a challenging topic, particularly because ... Full text Open Access Link to item Cite

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment.

Journal Article Proc Natl Acad Sci U S A · November 23, 2010 Hyperthermia (HT) is a strong adjuvant treatment with radiotherapy and chemotherapy because it causes tumor reoxygenation. However, the detailed molecular mechanisms of how HT enhances tumor oxygenation have not been elucidated. Here we report that 1 h of ... Full text Link to item Cite

Proteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+).

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2010 PURPOSE: To identify temporal changes in protein expression in the irradiated rat lung and generate putative mechanisms underlying the radioprotective effect of the manganese superoxide dismutase mimetic MnTE-2-PyP(5+). METHODS AND MATERIALS: Female Fische ... Full text Link to item Cite

Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential.

Journal Article Antioxid Redox Signal · September 15, 2010 Oxidative stress has become widely viewed as an underlying condition in a number of diseases, such as ischemia-reperfusion disorders, central nervous system disorders, cardiovascular conditions, cancer, and diabetes. Thus, natural and synthetic antioxidant ... Full text Open Access Link to item Cite

Thermodynamics and electrochemistry of manganese ortho-tetrakis(N-n- butylpyridinium-2-yl)porphyrin in aqueous solutions

Journal Article Journal of Coordination Chemistry · July 20, 2010 Spectrophotometric pH-titrations (1 < pH < 12) of manganese ortho-tetrakis(N-n-butylpyridinium-2-yl)porphyrin (MnTnBu-2-PyP) have been performed in aqueous solution at various temperatures and ionic strengths, studying complexes of various manganese oxidat ... Full text Cite

Water exchange rates of water-soluble manganese(III) porphyrins of therapeutical potential.

Journal Article Dalton Trans · May 14, 2010 The activation parameters and the rate constants of the water-exchange reactions of Mn(III)TE-2-PyP(5+) (meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin) as cationic, Mn(III)TnHex-2-PyP(5+) (meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin) as sterically sh ... Full text Open Access Link to item Cite

Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage.

Journal Article Free Radic Biol Med · April 15, 2010 Chronic production of reactive oxygen and nitrogen species is an underlying mechanism of irradiation (IR)-induced lung injury. The purpose of this study was to determine the optimum time of delivery of an antioxidant and redox-modulating Mn porphyrin, MnTE ... Full text Link to item Cite

Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide.

Journal Article Free Radic Res · April 2010 The present work addresses the role of two ortho-substituted Mn(III) N-alkylpyridylporphyrins, alkyl being ethyl in MnTE-2-PyP(5+) and n-hexyl in MnTnHex-2-PyP(5+), on the protection against the oxidant tert-butylhydroperoxide (TBHP). Their protective role ... Full text Link to item Cite

High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli.

Journal Article J Med Chem · December 10, 2009 Lipophilicity/bioavailibility of Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase (SOD) mimics has a major impact on their in vivo ability to suppress oxidative stress. Meta isomers are less potent SOD mimics than ortho analogues but are 10-fold ... Full text Link to item Cite

Determination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics.

Journal Article J Pharm Biomed Anal · December 5, 2009 The awareness of the beneficial effects of Mn porphyrin-based superoxide dismutase (SOD) mimics and peroxynitrite scavengers on decreasing oxidative stress injuries has increased the use of these compounds as mechanistic probes and potential therapeutics. ... Full text Link to item Cite

Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance.

Journal Article Neuroscience · December 1, 2009 Effective treatment of chronic pain with morphine is limited by decreases in the drug's analgesic action with chronic administration (antinociceptive tolerance). Because opioids are mainstays of pain management, restoring their efficacy has great clinical ... Full text Link to item Cite

Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor.

Journal Article Free Radic Biol Med · October 1, 2009 MnTE-2-PyP(5+) is a potent catalytic scavenger of reactive oxygen and nitrogen species, primarily superoxide and peroxynitrite. It therefore not only attenuates primary oxidative damage, but was found to modulate redox-based signaling pathways (HIF-1alpha, ... Full text Link to item Cite

Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.

Journal Article Free Radic Biol Med · October 1, 2009 Sustained oxidative stress is a known sequel to focal cerebral ischemia. This study examined the effects of treatment with a single dose or sustained infusion of the redox-modulating MnPorphyrin Mn(III)TDE-2-ImP(5+) on outcome from middle cerebral artery o ... Full text Link to item Cite

Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells.

Journal Article Free Radic Biol Med · August 1, 2009 We tested several classes of antioxidant manganese compounds for radioprotective effects using human lymphoblastoid cells: six porphyrins, three salens, and two cyclic polyamines. Radioprotection was evaluated by seven assays: XTT, annexin V and propidium ... Full text Link to item Cite

Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.

Journal Article Free Radic Biol Med · July 1, 2009 Mn(III) N-alkylpyridylporphyrins are among the most potent known SOD mimics and catalytic peroxynitrite scavengers and modulators of redox-based cellular transcriptional activity. In addition to their intrinsic antioxidant capacity, bioavailability plays a ... Full text Link to item Cite

Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death.

Journal Article Free Radic Res · April 2009 In vivo investigations have confirmed the beneficial effects of hydrophilic, cationic Mn(III) porphyrin-based catalytic antioxidants in different models of oxidative stress. Using a cell culture model of rat mixed neuronal/glial cells, this study investiga ... Full text Link to item Cite

IDH1 and IDH2 mutations in gliomas.

Journal Article N Engl J Med · February 19, 2009 BACKGROUND: A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that wer ... Full text Link to item Cite

Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.

Journal Article Free Radic Biol Med · January 15, 2009 Severe pain syndromes reduce the quality of life of patients with inflammatory and neoplastic diseases, partly because reduced analgesic effectiveness with chronic opiate therapy (i.e., tolerance) leads to escalating doses and distressing side effects. Per ... Full text Link to item Cite

Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy.

Journal Article Free Radic Biol Med · January 15, 2009 MnTBAP is often referred to as an SOD mimic in numerous models of oxidative stress. We have recently reported that pure MnTBAP does not dismute superoxide, but commercial or poorly purified samples are able to perform O2.- dismutation with low-to-moderate ... Full text Link to item Cite

Effect of potent redox-modulating manganese porphyrin, MnTM-2-PyP, on the Na(+)/H(+) exchangers NHE-1 and NHE-3 in the diabetic rat.

Journal Article Redox Rep · 2009 Increased expression of Na(+)/H(+) exchanger (NHE) and Na(+),K(+)-ATPase activity have been demonstrated in diabetic nephropathy and are implicated in the development of hypertension. The aim of this study was to investigate the effect of a synthetic manga ... Full text Link to item Cite

Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes.

Journal Article J Pharm Biomed Anal · November 4, 2008 Cationic Mn porphyrins are among the most potent SOD mimics and peroxynitrite scavengers. They have been widely and successfully used in different models of oxidative stress and are either progressing towards or are in phase I of clinical trials. The most ... Full text Link to item Cite

Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice.

Journal Article Free Radic Biol Med · October 1, 2008 Mn(III) tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), a potent catalytic superoxide and peroxynitrite scavenger, has been beneficial in several oxidative stress-related diseases thus far examined. Pharmacokinetic studies are essential for the ... Full text Link to item Cite

SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself.

Journal Article Arch Biochem Biophys · September 1, 2008 Mn porphyrins are among the most efficient SOD mimics with potency approaching that of SOD enzymes. The most potent ones, Mn(III) N-alkylpyridylporphyrins bear positive charges in a close proximity to the metal site, affording thermodynamic and kinetic fac ... Full text Link to item Cite

Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier.

Journal Article Free Radic Biol Med · July 15, 2008 Understanding the factors that determine the ability of Mn porphyrins to scavenge reactive species is essential for tuning their in vivo efficacy. We present herein the revised structure-activity relationships accounting for the critical importance of elec ... Full text Link to item Cite

An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation.

Journal Article Free Radic Res · July 2008 The isocitrate dehydrogenases (ICDs) catalyse the oxidative decarboxylation of isocitrate to alpha-ketoglutarate and can use either NAD(+) or NADP(+) as a cofactor. Recent studies demonstrate that the NADP(+)-dependent isocitrate dehydrogenase, as a source ... Full text Link to item Cite

A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury.

Journal Article Neuroscience · April 22, 2008 Alzheimer's disease (AD) is associated with beta-amyloid accumulation, oxidative stress and mitochondrial dysfunction. However, the effects of genetic mutation of AD on oxidative status and mitochondrial manganese superoxide dismutase (MnSOD) production du ... Full text Link to item Cite

Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection.

Journal Article Free Radic Biol Med · March 15, 2008 Development of radiation therapy (RT)-induced lung injury is associated with chronic production of reactive oxygen and nitrogen species (ROS/RNS). MnTE-2-PyP5+ is a catalytic Mn porphyrin mimic of SOD, already shown to protect lungs from RT-induced injury ... Full text Link to item Cite

Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: the effect of charge distribution.

Journal Article Dalton Trans · March 7, 2008 We evaluate herein the impact of positive charge distribution on the in vitro and in vivo properties of Mn porphyrins as redox modulators possessing the same overall 5+ charge and of minimal stericity demand: Mn(III) meso-tetrakis(trimethylanilinium-4-yl)p ... Full text Link to item Cite

Pure manganese(III) 5,10,15,20-tetrakis(4-benzoic acid)porphyrin (MnTBAP) is not a superoxide dismutase mimic in aqueous systems: a case of structure-activity relationship as a watchdog mechanism in experimental therapeutics and biology.

Journal Article J Biol Inorg Chem · February 2008 Superoxide is involved in a plethora of pathological and physiological processes via oxidative stress and/or signal transduction pathways. Superoxide dismutase (SOD) mimics have, thus, been actively sought for clinical and mechanistic purposes. Manganese(I ... Full text Link to item Cite

Design and synthesis of manganese porphyrins with tailored lipophilicity: investigation of redox properties and superoxide dismutase activity.

Journal Article Bioorg Med Chem · November 15, 2007 Thirteen new manganese porphyrins and two porphodimethenes bearing one to three different substituents at the meso positions in a variety of architectures have been synthesized. The substituents employed generally are (i) electron-withdrawing to tune the r ... Full text Link to item Cite

Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation.

Journal Article Free Radic Res · November 2007 The objective of this study was to determine whether administration of a catalytic antioxidant, Mn(III) tetrakis(N,N'-diethylimidazolium-2-yl) porphyrin, AEOL10150, reduces the severity of long-term lung injury induced by fractionated radiation (RT). Fishe ... Full text Link to item Cite

Inactivation of metabolic enzymes by photo-treatment with zinc meta N-methylpyridylporphyrin.

Journal Article Biochim Biophys Acta · November 2007 Cell proliferation is notably dependent on energy supply and generation of reducing equivalents in the form of NADPH for reductive biosynthesis. Blockage of pathways generating energy and reducing equivalents has proved successful for cancer treatment. We ... Full text Link to item Cite

Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion.

Journal Article Free Radic Biol Med · May 15, 2007 Renal ischemia/reperfusion (I/R) injury often occurs as a result of vascular surgery, organ procurement, or transplantation. We previously showed that renal I/R results in ATP depletion, oxidant production, and manganese superoxide dismutase (MnSOD) inacti ... Full text Link to item Cite

Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria.

Journal Article Free Radic Biol Med · April 15, 2007 The Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnIIITE-2-PyP5+ (AEOL-10113) has proven effective in treating oxidative stress-induced conditions including cancer, radiation damage, diabetes, and central nervous system trauma. The ortho cationi ... Full text Link to item Cite

Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilage.

Journal Article J Rheumatol · February 2007 OBJECTIVE: Osteoarthritis is characterized by the degradation of articular cartilage. The catabolic activity of chondrocytes is partly regulated by nitric oxide (NO), which with superoxide (O2-) leads to the formation of peroxynitrite (OONO-), a potentiall ... Link to item Cite

Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2007 PURPOSE: To determine whether administration of a catalytic antioxidant, Mn(III) tetrakis(N,N'-diethylimidazolium-2-yl) porphyrin, AEOL 10150, with superoxide dismutase (SOD) mimetic properties, reduces the severity of radiation-induced injury to the lung ... Full text Link to item Cite

Superoxide dismutase mimetic reduces hypoxia-induced O2*-, TGF-beta, and VEGF production by macrophages.

Journal Article Free Radic Res · January 2007 Normal tissue injury poses a major limitation to the success of radiation therapy (RT) in the treatment of solid tumors. We propose that radiation-induced lung injury is a result of chronic oxidative stress propagated by hypoxia-induced macrophage activati ... Full text Link to item Cite

Induction of oxidative cell damage by photo-treatment with zinc meta N-methylpyridylporphyrin.

Journal Article Free Radic Res · January 2007 We have previously reported that isomeric Zn(II) N-methylpyridylporphyrins (ZnTM-2(3,4)-PyP4 + ) can act as photosensitizers with efficacy comparable to that of hematoporphyrin derivative (HpD) in preventing cell proliferation and causing cell death in vit ... Full text Link to item Cite

Design and biodistribution of MN porphyrin-based therapeutics for oxidative stress

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2007 Link to item Cite

New approach to the activation of anti-cancer pro-drugs by metalloporphyrin-based cytochrome P450 mimics in all-aqueous biologically relevant system.

Journal Article J Inorg Biochem · November 2006 The low-molecular weight water-soluble Fe(III) and Mn(III) porphyrins--in biologically relevant phosphate-buffered saline medium with ascorbic acid as a source of electrons, under aerobic conditions but without co-oxidant - catalyze the hydroxylation of an ... Full text Link to item Cite

Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: a catalytic cycle for the reduction of peroxynitrite.

Journal Article Free Radic Biol Med · August 1, 2006 The reduction of manganese(III) meso-tetrakis((N-ethyl)pyridinium-2-yl)porphyrin (MnTE-2-PyP) to manganese(II) was catalyzed by flavoenzymes such as xanthine oxidase and glucose oxidase, and by Complex I and Complex II of the mitochondrial electron transpo ... Full text Link to item Cite

ROS production and angiogenic regulation by macrophages in response to heat therapy.

Journal Article Int J Hyperthermia · June 2006 PURPOSE: It has been well established that inadequate blood supply combined with high metabolic rates of oxygen consumption results in areas of low oxygen tension (<1%) within malignant tumours and that elevating tumour temperatures above 39 degrees Celsiu ... Full text Link to item Cite

Photosensitizing action of isomeric zinc N-methylpyridylporphyrins in human carcinoma cells.

Journal Article Free Radic Res · May 2006 The success of photodynamic therapy (PDT), as a minimally invasive approach, in treating both neoplastic and non-neoplastic diseases has stimulated the search for new compounds with potential application in PDT. We have previously reported that Zn(II) N-al ... Full text Link to item Cite

Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.

Journal Article Eur J Pharmacol · February 15, 2006 Closed head injury induces cerebral oxidative stress. The efficacy of a Mn (III) porphyrin catalytic antioxidant was assessed in a mouse closed head injury model. Mice were subjected to closed head injury and treated 15 min later with an i.v. bolus of vehi ... Full text Link to item Cite

New PEG-ylated Mn(III) porphyrins approaching catalytic activity of SOD enzyme.

Journal Article Dalton Trans · January 28, 2006 Two new tri(ethyleneglycol)-derivatized Mn(III) porphyrins were synthesized with the aim of increasing their bioavailability, and blood-circulating half-life. These are Mn(III) tetrakis(N-(1-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)pyridinium-2-yl)porphyrin, Mn ... Full text Link to item Cite

Metalloporphyrin mediated protection from renal ischemia/reperfusion injury

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2006 Link to item Cite

The involvement of superoxide and iNOS-derived NO in cardiac dysfunction induced by pro-inflammatory cytokines.

Journal Article J Mol Cell Cardiol · November 2005 Pro-inflammatory cytokines have been shown to depress myocardial mechanical function by enhancing peroxynitrite generation in the heart. The contribution of NO synthesized by different NOS isoforms, as well as the contribution of superoxide to this mechani ... Full text Link to item Cite

A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2005 PURPOSE: To determine the effect of the superoxide dismutase mimetic Mn(III) tetrakis(N-ethylpyridinium-2-yl)porphyrin (MnTE-2-PyP(5+)) on tumor radioresponsiveness. METHODS AND MATERIALS: Various rodent tumor (4T1, R3230, B16) and endothelial (SVEC) cell ... Full text Link to item Cite

p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase.

Journal Article Cancer Res · May 1, 2005 The tumor suppressor gene p53 is activated by reactive oxygen species-generating agents. After activation, p53 migrates to mitochondria and nucleus, a response that eventually leads to apoptosis, but how the two events are related is unknown. Herein, we sh ... Full text Link to item Cite

A mechanism-based antioxidant approach for the reduction of skin carcinogenesis.

Journal Article Cancer Res · February 15, 2005 Studies in our laboratories showed that overexpression of manganese superoxide dismutase (MnSOD) reduced tumor incidence in a multistage skin carcinogenesis mouse model. However, reduction of MnSOD by heterozygous knockout of the MnSOD gene (MnSOD KO) did ... Full text Link to item Cite

Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth.

Journal Article Eukaryot Cell · January 2005 Manganese superoxide dismutase is an essential component of the mitochondrial antioxidant defense system of most eukaryotes. In the present study, we used a reverse-genetics approach to assess the contribution of the Cryptococcus neoformans manganese super ... Full text Link to item Cite

A manganese porphyrin suppresses oxidative stress and extends the life span of streptozotocin-diabetic rats.

Journal Article Free Radic Res · January 2005 Enhanced oxidative stress due to hyperglycemia has been implicated in diabetic complications and is considered a major cause of cell and tissue damage. The aim of the present study was to investigate whether synthetic manganese porphyrin, Mn(III) 5,10,15,2 ... Full text Link to item Cite

Mouse spinal cord compression injury is ameliorated by intrathecal cationic manganese(III) porphyrin catalytic antioxidant therapy.

Journal Article Neurosci Lett · August 12, 2004 This study evaluated the effects of the cationic manganese(III) tetrakis(N,N'-diethylimidazolium-2-yl)porphyrin catalytic antioxidant Mn(III)TDE-2-ImP5+ (AEOL 10150) on outcome from spinal cord compression (SCC) in the mouse. C57BL/6J mice were subjected t ... Full text Link to item Cite

Oxidants, antioxidants and the ischemic brain.

Journal Article J Exp Biol · August 2004 Despite numerous defenses, the brain is vulnerable to oxidative stress resulting from ischemia/reperfusion. Excitotoxic stimulation of superoxide and nitric oxide production leads to formation of highly reactive products, including peroxynitrite and hydrox ... Full text Link to item Cite

Tetrahydrobiopterin rapidly reduces the SOD mimic Mn(III) ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin.

Journal Article Free Radic Biol Med · August 1, 2004 Mn(III) ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin (Mn(III)TE-2-PyP(5+)) effectively scavenges reactive oxygen and nitrogen species in vitro, and protects in vivo, in different rodent models of oxidative stress injuries. Further, Mn(III)TE-2-PyP(5+) w ... Full text Link to item Cite

Complementation of SOD-deficient Escherichia coli by manganese porphyrin mimics of superoxide dismutase activity.

Journal Article Free Radic Biol Med · August 1, 2004 Cationic Mn(III) porphyrins substituted on the methine bridge carbons (meso positions) with N-alkylpyridinium or N,N'-diethylimidazolium groups have been prepared and characterized, both chemically and as SOD mimics. The ortho tetrakis N-methylpyridinium c ... Full text Link to item Cite

New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins.

Journal Article Dalton Trans · June 7, 2004 Three new Mn(III) porphyrin catalysts of O2.-dismutation (superoxide dismutase mimics), bearing ether oxygen atoms within their side chains, were synthesized and characterized: Mn(III) 5,10,15,20-tetrakis[N-(2-methoxyethyl)pyridinium-2-yl]porphyrin (MnTMOE ... Full text Link to item Cite

A no-laminectomy spinal cord compression injury model in mice.

Journal Article J Neurotrauma · May 2004 The purpose of this study was to develop a minimally invasive recovery model of spinal cord injury in the C57Bl/6J mouse. Without laminectomy, the epidural space was exposed by disruption of the T10-T11 interspinous ligament. Perpendicular to the rostral-c ... Full text Link to item Cite

Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia.

Journal Article Circulation · December 2, 2003 BACKGROUND: Peroxisome proliferator-activated receptor (PPAR) signaling pathways have been reported to exert anti-inflammatory effects and attenuate atherosclerosis formation. However, the mechanisms responsible for their anti-inflammatory and antiatherosc ... Full text Link to item Cite

Peroxynitrite flux-mediated LDL oxidation is inhibited by manganese porphyrins in the presence of uric acid.

Journal Article Free Radic Biol Med · November 15, 2003 We have studied the role of three Mn(III)porphyrins differing in charge, alkyl substituent length and reactivity, on LDL exposed to low fluxes of peroxynitrite (PN) in the presence of uric acid. Mn(III)porphyrins (5 microM, MnTE-2-PyP(5+), MnTnOct-2-PyP(5+ ... Full text Link to item Cite

Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion.

Journal Article J Biol Chem · July 25, 2003 We have studied the reaction kinetics of ten manganese porphyrins, differing in their meso substituents, with peroxynitrite (ONOO-) and carbonate radical anion (CO3.) using stopped-flow and pulse radiolysis, respectively. Rate constants for the reactions o ... Full text Link to item Cite

Electrostatic contribution in the catalysis of O2*- dismutation by superoxide dismutase mimics. MnIIITE-2-PyP5+ versus MnIIIBr8T-2-PyP+.

Journal Article J Biol Chem · February 28, 2003 The Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin (Mn(III)TE-2-PyP(5+)) is a potent superoxide dismutase (SOD) mimic in vitro and was beneficial in rodent models of oxidative stress pathologies. Its high activity has been ascribed to both the favo ... Full text Link to item Cite

Meso tetrakis ortho-, meta-, and para-n-alkylpyridinioporphyrins: Kinetics of copper(II) and zinc(II) incorporation and zinc porphyrin demetalation

Journal Article Journal of Porphyrins and Phthalocyanines · January 1, 2003 The relative reactivities of the tetrakis(N-alkylpyridinium-X-yl)-porphyrins where X = 4 (alkyl = methyl, ethyl, n-propyl), X = 3 (methyl), and X = 2 (methyl, ethyl, n-propyl, n-butyl, n-hexyl, n-octyl) were studied in aqueous solution. From the ionic stre ... Full text Cite

Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity.

Journal Article Free Radic Biol Med · December 15, 2002 Superoxide plays a role in blood pressure regulation in certain vascular diseases, however, its involvement in regulating basal blood pressure is uncertain. Vascular superoxide concentrations are limited by extracellular superoxide dismutase (EC-SOD), whic ... Full text Link to item Cite

Catalytic Antioxidants as Novel Pharmacologic Approaches to Treatment of Ischemic Brain Injury.

Journal Article Drug News Perspect · December 2002 Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are increased following acute brain ischemia. These species have been associated with secondary injury that amplifies the magnitude of final neuronal damage. Work with both biochemical analy ... Full text Link to item Cite

Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia.

Journal Article Free Radic Biol Med · October 1, 2002 Reactive oxygen species play a role in the response of brain to ischemia. The effects of metalloporphyrin catalytic antioxidants (AEOL 10113 and AEOL 10150) were examined after murine middle cerebral artery occlusion (MCAO). Ninety minutes after reperfusio ... Full text Link to item Cite

A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.

Journal Article Free Radic Biol Med · September 15, 2002 Radiation therapy (RT) is an important therapeutic modality in the treatment of thoracic tumors. The maximum doses to these tumors are often limited by the radiation tolerance of lung tissues. Lung injury from ionizing radiation is believed to be a consequ ... Full text Link to item Cite

Isomeric N-alkylpyridylporphyrins and their Zn(II) complexes: inactive as SOD mimics but powerful photosensitizers.

Journal Article Arch Biochem Biophys · June 15, 2002 The ortho, meta, and para isomers of cationic N-alkylpyridylporphyrins and their Zn(II) complexes were compared in terms of their photodynamic properties. The ortho Zn(II) complex was found to be the most efficient in causing photooxidation of NADH in vitr ... Full text Link to item Cite

Thermodynamics, kinetics, and mechanism of the stepwise dissociation and formation of Tris(L-lysinehydroxamato)iron(III) in aqueous acid.

Journal Article Inorg Chem · March 25, 2002 pK(a) values for the hydroxamic acid, alpha-NH(3)(+), and epsilon-NH(3)(+) groups of L-lysinehydroxamic acid (LyHA, H(3)L(2+)) were found to be 6.87, 8.89, and 10.76, respectively, in aqueous solution (I = 0.1 M, NaClO(4)) at 25 degrees C. O,O coordination ... Full text Link to item Cite

A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone.

Journal Article Diabetes · February 2002 We present here the first report of a metalloporphyrin-based antioxidant that can prevent or delay the onset of autoimmune diabetes. Type 1 diabetes is an autoimmune process whereby T-cells recognize pancreatic beta-cell antigens and initiate a leukocyte i ... Full text Link to item Cite

Manganese(III) meso-tetrakis(ortho-N-alkylpyridyl)porphyrins. Synthesis, characterization, and catalysis of O2/·- dismutation

Journal Article Journal of the Chemical Society, Dalton Transactions · January 1, 2002 A series of ortho isomers of meso-tetrakis(N-alkylpyridyl)porphyrins (alkyl being methyl, ethyl, n-propyl, n-butyl, n-hexyl, and n-octyl) and their Mn(III) complexes were synthesized and characterized by elemental analysis, uv/vis spectroscopy, electrospra ... Full text Cite

Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease.

Journal Article Proc Natl Acad Sci U S A · December 18, 2001 Plasma xanthine oxidase (XO) activity was defined as a source of enhanced vascular superoxide (O(2)( *-)) and hydrogen peroxide (H(2)O(2)) production in both sickle cell disease (SCD) patients and knockout-transgenic SCD mice. There was a significant incre ... Full text Link to item Cite

Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant.

Journal Article J Neurosci · July 1, 2001 Reactive oxygen species contribute to ischemic brain injury. This study examined whether the porphyrin catalytic antioxidant manganese (III) meso-tetrakis (N-ethylpyridinium-2-yl)porphyrin (MnTE-2-PyP(5+)) reduces oxidative stress and improves outcome from ... Full text Link to item Cite

Manganese(III) complexes with porphyrins and related compounds as catalytic scavengers of superoxide

Journal Article Inorganica Chimica Acta · May 28, 2001 Two groups of Mn-based catalytic antioxidants are described in terms of their catalytic activities and electrochemical properties. In the first group, manganese porphyrins, phthalocyanine, and porphyrazine employ the Mn(III)/Mn(II) couple in the catalysis ... Full text Cite

Manganese(III) biliverdin IX dimethyl ester: a powerful catalytic scavenger of superoxide employing the Mn(III)/Mn(IV) redox couple.

Journal Article Inorg Chem · February 12, 2001 A manganese(III) complex of biliverdin IX dimethyl ester, (MnIIIBVDME)2, was prepared and characterized by elemental analysis, UV/vis spectroscopy, cyclic voltammetry, chronocoulometry, electrospray mass spectrometry, freezing-point depression, magnetic su ... Full text Link to item Cite

Nitrosylation of manganese(II) tetrakis(N-ethylpyridinium-2-yl)porphyrin: a simple and sensitive spectrophotometric assay for nitric oxide.

Journal Article Nitric Oxide · October 2000 Reaction between NO(*) and manganese tetrakis(N-ethylpyridinium-2-yl)porphyrin (Mn(III)TE-2-PyP(5+)) was investigated at 25 degrees C. At high excess of NO(*) (1.5 mM) the reaction with the oxidized, air-stable form Mn(III)TE-2-PyP(5+) (5 microM), proceeds ... Full text Link to item Cite

Manganese-porphyrin reactions with lipids and lipoproteins.

Journal Article Free Radic Biol Med · April 1, 2000 Manganese porphyrin complexes serve to catalytically scavenge superoxide, hydrogen peroxide, and peroxynitrite. Herein, reactions of manganese 5,10,15,20-tetrakis(N-ethylpyridinium-2-yl)porphyrin (MnTE-2-PyP(5+)) with lipids and lipid hydroperoxides (LOOH) ... Full text Link to item Cite

Electrospray mass spectrometry of isomeric tetrakis(N-alkylpyridyl)porphyrins and their manganese(III) and iron(III) complexes

Journal Article Journal of Porphyrins and Phthalocyanines · January 1, 2000 Manganese(III) complexes of isomeric tetrakis(N-alkylpyridyl)porphyrins (N-alkyl = N-methyl, M or N-ethyl, E), MnTM(E)-2(3,4)-PyP5+, are being developed as superoxide dismutase (SOD) mimics. Simultaneously, techniques for their purification, identification ... Full text Cite

Electrospray mass spectrometry of isomeric tetrakis(N-alkylpyridyl)porphyrins and their manganese(III) and iron(III) complexes

Journal Article Journal of Porphyrins and Phthalocyanines · January 1, 2000 Manganese(III) complexes of isomeric tetrakis(N-alkylpyridyl)porphyrins (N-alkyl = N-methyl, M or N-ethyl, E), MnTM(E)-2(3,4)-PyP5+, are being developed as superoxide dismutase (SOD) mimics. Simultaneously, techniques for their purification, identification ... Full text Cite

Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants.

Journal Article Chem Res Toxicol · May 1999 Three isomers of manganese(III) 5,10,15, 20-tetrakis(N-methylpyridyl)porphyrin (MnTMPyP) were evaluated for their reaction with peroxynitrite. The Mn(III) complexes reacted with peroxynitrite anion with rate constants of 1.85 x 10(7), 3.82 x 10(6), and 4.3 ... Full text Link to item Cite

Metalloporphyrins are potent inhibitors of lipid peroxidation.

Journal Article Free Radic Biol Med · March 1999 The objectives of these studies were to determine whether metalloporphyrins could inhibit lipid peroxidation, characterize factors that influence their potency and compare their potency to prototypical antioxidants. Lipid peroxidation was initiated with ir ... Full text Link to item Cite

Relationship among redox potentials, proton dissociation constants of pyrrolic nitrogens, and in vivo and in vitro superoxide dismutating activities of manganese(III) and iron(III) water-soluble porphyrins

Journal Article Inorganic Chemistry · January 1, 1999 The log kcat values for the dismutation of O2- by a series of monohydroxoiron(III) and aquamanganese(III) porphyrins, including ortho, meta, and para isomers of 5,10,15,20-tetrakis(N-alkylpyridiniumyl)porphyrins, were found to vary linearly with the metal- ... Full text Cite

Syntheses and superoxide dismuting activities of partially (1-4) β-chlorinated derivatives of manganese(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin

Journal Article Inorganic Chemistry · January 1, 1999 Manganese(III) β-mono-, di-, tri-, and tetrachloro-5,10,15,20-tetrakis(N-ethylpyridinium-2-yl)porphyrin (MnClx-TE-2-PyP5+, with x from 1 to 4) were prepared through β-chlorination of 5,10,15,20-tetrakis(2-pyridyl)porphyrin (H2T-2-PyP) followed by N-ethylat ... Full text Cite

The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic.

Journal Article J Biol Chem · September 18, 1998 The ortho, meta, and para isomers of manganese(III) 5,10,15, 20-tetrakis(N-methylpyridyl)porphyrin, MnTM-2-PyP5+, MnTM-3-PyP5+, and MnTM-4-PyP5+, respectively, were analyzed in terms of their superoxide dismutase (SOD) activity in vitro and in vivo. The im ... Full text Link to item Cite

Lariat Ether Carboxylic Acids as Ionizable Hosts in the Second Coordination Sphere of the Siderophore Ferrioxamine B in Chloroform

Journal Article Inorganic Chemistry · January 1, 1998 A new series of lariat ether carboxylic acids (LnCOOH) was synthesized with different lengths of side arm (6, 9, and 12 atom spacers between the benzo-18-crown-6 crown ether ring and the carboxylic acid functional group). These lariat ethers were used as n ... Full text Cite

A potent superoxide dismutase mimic: manganese beta-octabromo-meso-tetrakis-(N-methylpyridinium-4-yl) porphyrin.

Journal Article Arch Biochem Biophys · July 15, 1997 Variously modified metalloporphyrins offer a promising route to stable and active mimics of superoxide dismutase (SOD). Here we explore bromination on the pyrroles as a means of increasing the redox potentials and the catalytic activities of the copper and ... Full text Link to item Cite

Solvent effect on second-sphere coordination of ferrioxamine B with substituted 18-crown-6 and 30-crown-10 crown ethers in dichloromethane as compared to chloroform

Journal Article Inorganica Chimica Acta · July 15, 1997 Stability constants for the second-sphere association of picrate and perchlorate salts of ferrioxamine B (FeHDFB+) with the substituted crown ethers (CE) 18-crown-6, cis-dicyclohexano-18-crown-6, benzo-18-crown-6, dibenzo-18-crown-6 and dibenzo-30-crown-10 ... Full text Cite

Second-Sphere Coordination of Ferrioxamine B and Association of Deferriferrioxamine B, CH(3)(CH(2))(4)NH(3)(+), NH(4)(+), K(+), and Mg(2+) with Synthetic Crown Ethers and the Natural Ionophores Valinomycin and Nonactin in Chloroform.

Journal Article Inorg Chem · April 10, 1996 The interaction of ferrioxamine B, FeHDFB(+), through a protonated amine side chain, with various host ionophore structures to form a host-guest complex in the second coordination shell has been investigated. Host-guest association constants (K(a)) in wate ... Full text Link to item Cite

Molecular recognition of stable metal complexes through second-sphere coordination by macrocycles

Journal Article Pure and Applied Chemistry · January 1, 1996 An investigation of second coordination shell complexation of ferrioxamine B by crown ethers, natural ionophores, and other macrocycles through host-guest complexation of the pendant protonated amine group is presented. The influence of guest structure, ho ... Full text Cite

Second-Sphere Coordination of Ferrioxamine B and Association of Deferriferrioxamine B, CH3(CH2)4NH3+, NH4+, K+, and Mg2+ with Synthetic Crown Ethers and the Natural lonophores Valinomycin and Nonactin in Chloroform

Journal Article Inorganic Chemistry · 1996 The interaction of ferrioxamine B, FeHDFB+, through a protonated amine side chain, with various host ionophore structures to form a host-guest complex in the second coordination shell has been investigated. Host-guest association constants (Ka) in water sa ... Cite

Stereochemical factors affecting second-sphere co-ordination of ferrioxamine B with cis-syn-cis and cis-anti-cis isomers of dicyclohexano-18-crown-6 in chloroform and a comparison with alkali-metal and ammonium cations

Journal Article Journal of the Chemical Society, Dalton Transactions · December 1, 1995 Second-sphere co-ordination of ferrioxamine B [Fe(HL)]+ by dicyclohexano-18-crown-6 (eicosahydrodibenzo[b,k][1,4,7,10,13,16]hexaoxacyclooctadecine) occurs through host-guest complex formation with the protonated amine side chain (CH2)5NH3+. The influence o ... Full text Cite

The effect of detergents on the reduction of tetrazolium salts.

Journal Article Arch Biochem Biophys · December 1, 1995 Detergents, such as Triton X-100, markedly increase the reduction of tetrazolium salts by xanthine oxidase plus xanthine, or by NADH. This effect of detergent, in the case of the xanthine oxidase catalyzed process, is seen aerobically but not anaerobically ... Full text Link to item Cite

Influence of the Anion on the Stability of Second-Sphere Coordination of Ferrioxamine B with cis-Dicyclohexano-18-crown-6 in Chloroform

Journal Article Inorganic Chemistry · February 1, 1995 The influence of the anion X− on the stability of the supramolecular assembly FeHDFB+,CE,X− (I) where FeHDFB+ is ferrioxamine B, CE is dicyclohexano-18-crown-6, and X− is ClO4−, NO3−, Cl−, or picrate was investigated. The formation constants for these host ... Full text Cite

Hydrolysis of Ferrioxamine B in Aqueous Micellar Solution

Journal Article Inorganic Chemistry · July 1, 1994 The association constant for the Fe(III) complex of the linear trihydroxamic acid siderophore ferrioxamine B (FeHDFB+; HDFB2- = H3N-[(CH2)5-N(O)C(O)-(CH2)2C(O)NH-)]2(CH2)5-N(O)C(O)-CH3) binding to sodium dodecyl sulfate (SDS) micelles was determined by ult ... Full text Cite

Supramolecular Assembly Formation of Ferrioxamine B and Its Al(III), Ga(III), and In(III) Analogues with Dicyclohexano-18-Crown-6 in Chloroform

Journal Article Journal of the American Chemical Society · June 1, 1994 We have shown that the crown ether dicyclohexano-18-crown-6 recognizes the terminal amine group of deferriferrioxamine B (H4DFB+) and its Al(III), Ga(III), Fe(III), and In(III) complexes (MHDFB+) by host-guest complex formation. Host-guest formation consta ... Full text Cite

The Influence of the Various Types of Binder on the burning characteristics of the magnesium‐, boron‐, and aluminum‐based igniters

Journal Article Propellants, Explosives, Pyrotechnics · January 1, 1994 The behaviour of six different types of binders phenol‐formaldehyde resin, shellac, polyvinylchloride, ethylcellulose, nitrocellulose, and fluorel was investigated in pyrotechnic compositions on the basis of magnesium, boron and aluminum. It has been found ... Full text Cite

Functional and chemical characterization of the aging process of an igniter

Journal Article Propellants, Explosives, Pyrotechnics · January 1, 1993 The igniter consisting of 34% Mg, 60% KNO3, 3% KClO4 and 3% organic binder was subjected to accelerated aging under the conditions of 85% relative humidity at 65°C, 75°C and 85°C, and at 75°C with 92% relative humidity. Chemical aging was followed through ... Full text Cite

The stability characterization of the pyrotechnic system. The degradation of the nitrate oxidant in the presence of the magnesium under the accelerated aging conditions

Journal Article Propellants, Explosives, Pyrotechnics · January 1, 1992 The degradation of the nitrate oxidant was followed in the course of the aging process of tracer pyrotechnic mix containing 22.0 % Mg, 46.0 % Sr(NO3)2, 22.0 % KCIO4, 9.0 % Al‐Mg alloy and 4.0 % organic binder. The accelerated aging was conducted under the ... Full text Cite

Siderophore chemistry of vanadium. Kinetics and equilibrium of interaction between vanadium(IV) and desferrioxamine B in aqueous acidic solutions

Journal Article Inorganic Chemistry · January 1, 1991 The kinetics and equilibrium of interaction between vanadyl sulfate and a natural trihydroxamate-based siderophore, desferrioxamine B methanesulfonate, were studied spectrophotometrically in acidic aqueous perchlorate solutions of 2.0 M ionic strength. The ... Full text Cite

Aging of Pyrotechnic Composition. The reliability of x‐ray diffraction data for estimation of the quality of signal mix

Journal Article Propellants, Explosives, Pyrotechnics · January 1, 1989 The physical and chemical characteristics of green signal pyrotechnic mix, before and after destabilization caused by the action of increased humidity at different temperatures, were determined. Data obtained by the means of X‐ray diffraction. IR spectrosc ... Full text Cite

Aging of Pyrotechnik Compositions. The investigation of chemical changes by IR spectroscopy and x‐ray diffraction

Journal Article Propellants, Explosives, Pyrotechnics · January 1, 1989 The aging of tracers, containing different amounts of Mg, Sr(NO3)2, KClO4, Al‐Mg alloy and organic binder, was conducted under the conditions of 50.0% and 98.5% relative humidities at 75 °C, and of 98.5% relative humidity at 25 °C. IR spectroscopy and X‐ra ... Full text Cite

Method of obtaining gallium from aluminate solution by electrolysis

Journal Article Materials Science and Technology (United Kingdom) · January 1, 1986 Gallium is an increasingly important material in the fields of semiconductors and energy transfer. A prime source of gallium is the aluminate solution that remains after the purification of bauxite. The authors have sought a way of reclaiming gallium econo ... Full text Cite