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Jacob Niall Schroder

Assistant Professor of Surgery
Surgery, Cardiovascular and Thoracic Surgery

Selected Publications


Surgical Treatment of Tricuspid Valve Regurgitation in Patients Undergoing Left Ventricular Assist Device Implantation: Interim analysis of the TVVAD trial.

Journal Article J Thorac Cardiovasc Surg · May 2024 OBJECTIVES: Right heart failure remains a serious complication of left ventricular assist device therapy. Many patients presenting for left ventricular assist device implantation have significant tricuspid regurgitation. It remains unknown whether concurre ... Full text Link to item Cite

Metabolomic profiling during ex situ normothermic perfusion before heart transplantation defines patterns of substrate utilization and correlates with markers of allograft injury.

Conference J Heart Lung Transplant · May 2024 BACKGROUND: Cardiac metabolism is altered in heart failure and ischemia-reperfusion injury states. We hypothesized that metabolomic profiling during ex situ normothermic perfusion before heart transplantation (HT) would lend insight into myocardial substra ... Full text Link to item Cite

Evaluating threshold for donor fraction cell-free DNA using clinically available assay for rejection in pediatric and adult heart transplantation.

Journal Article Pediatr Transplant · May 2024 BACKGROUND: The aims of the study were to assess the performance of a clinically available cell-free DNA (cfDNA) assay in a large cohort of pediatric and adult heart transplant recipients and to evaluate performance at specific cut points in detection of r ... Full text Link to item Cite

Outcomes in Heart Transplant Recipients by Bridge to Transplant Strategy When Using the SherpaPak Cardiac Transport System.

Journal Article ASAIO J · May 1, 2024 The last several years have seen a rise in use of mechanical circulatory support (MCS) to bridge heart transplant recipients. A controlled hypothermic organ preservation system, the SherpaPak Cardiac Transport System (SCTS), was introduced in 2018 and has ... Full text Link to item Cite

Recipient Outcomes With Extended Criteria Donors Using Advanced Heart Preservation: An Analysis of the GUARDIAN-Heart Registry.

Journal Article J Heart Lung Transplant · April 2024 BACKGROUND: The prevalence of end-stage heart failure and patients who could benefit from heart transplantation requires an expansion of the donor pool, relying on the transplant community to continually re-evaluate and expand the use of extended criteria ... Full text Link to item Cite

Impact of controlled hypothermic preservation on outcomes following heart transplantation.

Journal Article J Heart Lung Transplant · March 19, 2024 BACKGROUND: Severe primary graft dysfunction (PGD) is a major cause of early mortality after heart transplant, but the impact of donor organ preservation conditions on severity of PGD and survival has not been well characterized. METHODS: Data from US adul ... Full text Link to item Cite

Donor Heart Recovery and Preservation Modalities in 2024.

Journal Article JACC Heart Fail · March 2024 Historically, heart transplantation (HT) has relied on the use of traditional cold storage for donor heart preservation. This organ preservation modality has several limitations, including the risk for ischemic and cold-induced graft injuries that may cont ... Full text Link to item Cite

Increasing Utilization of Extended Criteria Donor Hearts for Transplantation: The OCS Heart EXPAND Trial.

Journal Article JACC Heart Fail · March 2024 BACKGROUND: Extended criteria donor (ECD) hearts available with donation after brain death (DBD) are underutilized for transplantation due to limitations of cold storage. OBJECTIVES: This study evaluated use of an extracorporeal perfusion system on donor h ... Full text Link to item Cite

Long-term predictors of morbidity and mortality in patients following LVAD replacement.

Journal Article Artif Organs · February 2024 BACKGROUND: As heart transplant guidelines evolve, the clinical indication for 73% of durable left ventricular assist device (LVAD) implants is now destination therapy. Although completely magnetically levitated LVAD devices have demonstrated improved dura ... Full text Link to item Cite

Value of nutritional indices in predicting survival free from pump replacement and driveline infections in centrifugal left ventricular assist devices

Journal Article JTCVS Open · January 1, 2024 Objective: There is a paucity of data assessing the impact of nutritional status on outcomes in patients supported with the HeartMate 3 (HM3) left ventricular assist device (LVAD). Methods: Patients ≥18 years of age who underwent HM3 LVAD implantation betw ... Full text Cite

Maternal and Pregnancy Outcomes Following Heart Transplantation in the United States.

Journal Article JACC Heart Fail · December 2023 BACKGROUND: Improved survival following heart transplantation (HT) has led to more recipients contemplating pregnancy, but data on outcomes are limited. OBJECTIVES: The authors used a national data set to investigate and describe outcomes of pregnancies an ... Full text Link to item Cite

Infarct exclusion repair of postmyocardial infarction ventricular septal rupture with a hybrid patch and septal occluder device compared with patch only.

Conference JTCVS Tech · December 2023 OBJECTIVE: We developed a hybrid technique for repairing post-myocardial infarction (MI) ventricular septal defect (VSD) that combines infarct exclusion with patch and a nitinol-mesh septal occluder device (SOD) to provide a scaffold to support the damaged ... Full text Link to item Cite

The Role of Recipient Thyroid Hormone Supplementation in Primary Graft Dysfunction After Heart Transplantation: A Propensity-Adjusted Analysis.

Journal Article J Cardiothorac Vasc Anesth · November 2023 OBJECTIVES: To investigate whether recipient administration of thyroid hormone (liothyronine [T3]) is associated with reduced rates of primary graft dysfunction (PGD) after orthotopic heart transplantation. DESIGN: Retrospective cohort study. SETTING: Sing ... Full text Link to item Cite

A Paradigm Shift in Heart Preservation: Improved Post-transplant Outcomes in Recipients of Donor Hearts Preserved With the SherpaPak System.

Journal Article ASAIO J · November 1, 2023 Traditional ice storage has been the historic standard for preserving donor's hearts. However, this approach provides variability in cooling, increasing risks of freezing injury. To date, no preservation technology has been reported to improve survival aft ... Full text Link to item Cite

Inhaled Epoprostenol Compared With Nitric Oxide for Right Ventricular Support After Major Cardiac Surgery.

Journal Article Circulation · October 24, 2023 BACKGROUND: Right ventricular failure (RVF) is a leading driver of morbidity and death after major cardiac surgery for advanced heart failure, including orthotopic heart transplantation and left ventricular assist device implantation. Inhaled pulmonary-sel ... Full text Open Access Link to item Cite

Health care resource utilization and clinical outcomes for adult heart transplant recipients with primary graft dysfunction.

Journal Article Clin Transplant · October 2023 INTRODUCTION: The advent of new technologies to reduce primary graft dysfunction (PGD) and improve outcomes after heart transplantation are costly. Adoption of these technologies requires a better understanding of health care utilization, specifically the ... Full text Link to item Cite

Use of microaxial flow pumps in adolescents.

Journal Article JTCVS Tech · October 2023 OBJECTIVES: The Impella 5.5 has been successfully used in the adult population; however, safety and efficacy data in patients aged less than 18 years are limited. METHODS: Six pediatric patients, aged 13 to 16 years and weighing 45 to 113 kg, underwent axi ... Full text Link to item Cite

Surgical Treatment of Tricuspid Valve Regurgitation in Patients Undergoing Left Ventricular Assist Device Implantation: Interim analysis of the TVVAD trial.

Journal Article J Thorac Cardiovasc Surg · May 2024 OBJECTIVES: Right heart failure remains a serious complication of left ventricular assist device therapy. Many patients presenting for left ventricular assist device implantation have significant tricuspid regurgitation. It remains unknown whether concurre ... Full text Link to item Cite

Metabolomic profiling during ex situ normothermic perfusion before heart transplantation defines patterns of substrate utilization and correlates with markers of allograft injury.

Conference J Heart Lung Transplant · May 2024 BACKGROUND: Cardiac metabolism is altered in heart failure and ischemia-reperfusion injury states. We hypothesized that metabolomic profiling during ex situ normothermic perfusion before heart transplantation (HT) would lend insight into myocardial substra ... Full text Link to item Cite

Evaluating threshold for donor fraction cell-free DNA using clinically available assay for rejection in pediatric and adult heart transplantation.

Journal Article Pediatr Transplant · May 2024 BACKGROUND: The aims of the study were to assess the performance of a clinically available cell-free DNA (cfDNA) assay in a large cohort of pediatric and adult heart transplant recipients and to evaluate performance at specific cut points in detection of r ... Full text Link to item Cite

Outcomes in Heart Transplant Recipients by Bridge to Transplant Strategy When Using the SherpaPak Cardiac Transport System.

Journal Article ASAIO J · May 1, 2024 The last several years have seen a rise in use of mechanical circulatory support (MCS) to bridge heart transplant recipients. A controlled hypothermic organ preservation system, the SherpaPak Cardiac Transport System (SCTS), was introduced in 2018 and has ... Full text Link to item Cite

Recipient Outcomes With Extended Criteria Donors Using Advanced Heart Preservation: An Analysis of the GUARDIAN-Heart Registry.

Journal Article J Heart Lung Transplant · April 2024 BACKGROUND: The prevalence of end-stage heart failure and patients who could benefit from heart transplantation requires an expansion of the donor pool, relying on the transplant community to continually re-evaluate and expand the use of extended criteria ... Full text Link to item Cite

Impact of controlled hypothermic preservation on outcomes following heart transplantation.

Journal Article J Heart Lung Transplant · March 19, 2024 BACKGROUND: Severe primary graft dysfunction (PGD) is a major cause of early mortality after heart transplant, but the impact of donor organ preservation conditions on severity of PGD and survival has not been well characterized. METHODS: Data from US adul ... Full text Link to item Cite

Donor Heart Recovery and Preservation Modalities in 2024.

Journal Article JACC Heart Fail · March 2024 Historically, heart transplantation (HT) has relied on the use of traditional cold storage for donor heart preservation. This organ preservation modality has several limitations, including the risk for ischemic and cold-induced graft injuries that may cont ... Full text Link to item Cite

Increasing Utilization of Extended Criteria Donor Hearts for Transplantation: The OCS Heart EXPAND Trial.

Journal Article JACC Heart Fail · March 2024 BACKGROUND: Extended criteria donor (ECD) hearts available with donation after brain death (DBD) are underutilized for transplantation due to limitations of cold storage. OBJECTIVES: This study evaluated use of an extracorporeal perfusion system on donor h ... Full text Link to item Cite

Long-term predictors of morbidity and mortality in patients following LVAD replacement.

Journal Article Artif Organs · February 2024 BACKGROUND: As heart transplant guidelines evolve, the clinical indication for 73% of durable left ventricular assist device (LVAD) implants is now destination therapy. Although completely magnetically levitated LVAD devices have demonstrated improved dura ... Full text Link to item Cite

Value of nutritional indices in predicting survival free from pump replacement and driveline infections in centrifugal left ventricular assist devices

Journal Article JTCVS Open · January 1, 2024 Objective: There is a paucity of data assessing the impact of nutritional status on outcomes in patients supported with the HeartMate 3 (HM3) left ventricular assist device (LVAD). Methods: Patients ≥18 years of age who underwent HM3 LVAD implantation betw ... Full text Cite

Maternal and Pregnancy Outcomes Following Heart Transplantation in the United States.

Journal Article JACC Heart Fail · December 2023 BACKGROUND: Improved survival following heart transplantation (HT) has led to more recipients contemplating pregnancy, but data on outcomes are limited. OBJECTIVES: The authors used a national data set to investigate and describe outcomes of pregnancies an ... Full text Link to item Cite

Infarct exclusion repair of postmyocardial infarction ventricular septal rupture with a hybrid patch and septal occluder device compared with patch only.

Conference JTCVS Tech · December 2023 OBJECTIVE: We developed a hybrid technique for repairing post-myocardial infarction (MI) ventricular septal defect (VSD) that combines infarct exclusion with patch and a nitinol-mesh septal occluder device (SOD) to provide a scaffold to support the damaged ... Full text Link to item Cite

The Role of Recipient Thyroid Hormone Supplementation in Primary Graft Dysfunction After Heart Transplantation: A Propensity-Adjusted Analysis.

Journal Article J Cardiothorac Vasc Anesth · November 2023 OBJECTIVES: To investigate whether recipient administration of thyroid hormone (liothyronine [T3]) is associated with reduced rates of primary graft dysfunction (PGD) after orthotopic heart transplantation. DESIGN: Retrospective cohort study. SETTING: Sing ... Full text Link to item Cite

A Paradigm Shift in Heart Preservation: Improved Post-transplant Outcomes in Recipients of Donor Hearts Preserved With the SherpaPak System.

Journal Article ASAIO J · November 1, 2023 Traditional ice storage has been the historic standard for preserving donor's hearts. However, this approach provides variability in cooling, increasing risks of freezing injury. To date, no preservation technology has been reported to improve survival aft ... Full text Link to item Cite

Inhaled Epoprostenol Compared With Nitric Oxide for Right Ventricular Support After Major Cardiac Surgery.

Journal Article Circulation · October 24, 2023 BACKGROUND: Right ventricular failure (RVF) is a leading driver of morbidity and death after major cardiac surgery for advanced heart failure, including orthotopic heart transplantation and left ventricular assist device implantation. Inhaled pulmonary-sel ... Full text Open Access Link to item Cite

Health care resource utilization and clinical outcomes for adult heart transplant recipients with primary graft dysfunction.

Journal Article Clin Transplant · October 2023 INTRODUCTION: The advent of new technologies to reduce primary graft dysfunction (PGD) and improve outcomes after heart transplantation are costly. Adoption of these technologies requires a better understanding of health care utilization, specifically the ... Full text Link to item Cite

Use of microaxial flow pumps in adolescents.

Journal Article JTCVS Tech · October 2023 OBJECTIVES: The Impella 5.5 has been successfully used in the adult population; however, safety and efficacy data in patients aged less than 18 years are limited. METHODS: Six pediatric patients, aged 13 to 16 years and weighing 45 to 113 kg, underwent axi ... Full text Link to item Cite

Epidemiology, management, and clinical outcomes of extrapulmonary Mycobacterium abscessus complex infections in heart transplant and ventricular assist device recipients.

Journal Article Am J Transplant · July 2023 Nontuberculous mycobacteria are emerging pathogens, yet data on the epidemiology and management of extrapulmonary nontuberculous mycobacteria infections in orthotopic heart transplantation (OHT) and ventricular assist device (VAD) recipients are scarce. We ... Full text Link to item Cite

Transplantation Outcomes with Donor Hearts after Circulatory Death.

Journal Article N Engl J Med · June 8, 2023 BACKGROUND: Data showing the efficacy and safety of the transplantation of hearts obtained from donors after circulatory death as compared with hearts obtained from donors after brain death are limited. METHODS: We conducted a randomized, noninferiority tr ... Full text Link to item Cite

The association with organ procurement techniques and early cardiac transplant outcomes using cardiac MRI.

Journal Article Clin Transplant · May 2023 BACKGROUND: Heart transplantation (HT) has historically been limited by organ availability. Use of donation after circulatory death (DCD) donors addresses this limitation by utilizing previously unused hearts through use of the Organ Care System (OCS). OBJ ... Full text Link to item Cite

Ex Vivo Gene Delivery to Porcine Cardiac Allografts Using a Myocardial-Enhanced Adeno-Associated Viral Vector.

Journal Article Hum Gene Ther · April 2023 Transplantation, the gold standard intervention for organ failure, is a clinical field that is ripe for applications of gene therapy. One of the major challenges in applying gene therapy to this field is the need for a method that achieves consistent and r ... Full text Link to item Cite

Multicenter Registry Using Propensity Score Analysis to Compare a Novel Transport/Preservation System to Traditional Means on Postoperative Hospital Outcomes and Costs for Heart Transplant Patients.

Journal Article ASAIO J · April 1, 2023 The standard method for cardiac allograft preservation for the past 50 years has been static storage using crushed ice. A heart transplant transportation system designed to improve preservation quality with temperature monitoring, the Paragonix SherpaPak C ... Full text Link to item Cite

Validation of donor fraction cell-free DNA with biopsy-proven cardiac allograft rejection in children and adults.

Journal Article J Thorac Cardiovasc Surg · February 2023 OBJECTIVES: Donor-specific cell-free DNA shows promise as a noninvasive marker for allograft rejection, but as yet has not been validated in both adult and pediatric recipients. The study objective was to validate donor fraction cell-free DNA as a noninvas ... Full text Link to item Cite

Selective Sinus Replacement for Aortic Root Aneurysm: Durable Approach in Selected Patients.

Journal Article Ann Thorac Surg · February 2023 BACKGROUND: Selective sinus replacement (SSR) allows a tailored repair approach in patients with sinus of Valsalva or asymmetric aortic root aneurysm. SSR avoids the need for coronary reimplantation for nondiseased sinuses and shortens operative time, alth ... Full text Link to item Cite

Improved Outcomes in Severe Primary Graft Dysfunction After Heart Transplantation Following Donation After Circulatory Death Compared With Donation After Brain Death.

Journal Article J Card Fail · January 2023 BACKGROUND: Primary graft dysfunction (PGD), the leading cause of early mortality after heart transplantation, is more common following donation after circulatory death (DCD) than donation after brain death (DBD). We conducted a single-center, retrospectiv ... Full text Link to item Cite

Cardiac Transplantation Utilizing Donation After Circulatory Death (DCD)

Chapter · January 1, 2023 Donation after circulatory death was historically referred to as non-heart-beating donation. Maastricht category III donors remain the only group relevant to heart donation at present. Each donor hospital has its own policy for the location of withdrawal o ... Full text Cite

Organ Procurement and Preservation

Chapter · January 1, 2023 Successful procurement and optimal cardiac preservation are the cornerstones of any successful heart transplant. This chapter reviews the technical and logistical challenges involved in the procurement of the donor heart and the variety of solutions and te ... Full text Cite

Epidemiology of surgical site infections after solid organ transplants in the period 2015-2019: A single-center retrospective cohort study.

Journal Article Am J Transplant · December 2022 Surgical site infections (SSI) are severe complications of solid organ transplant (SOT). This retrospective study assessed the epidemiology of and outcomes associated with invasive primary SSI (IP-SSI) occurring within 3 months of transplantation in adult ... Full text Open Access Link to item Cite

Cardiovascular mechanism of donor brain death and heart recipient survival.

Journal Article J Card Surg · December 2022 BACKGROUND: Heart donation after donor brain death from cardiac arrest despite successful resuscitation may be associated with worse recipient outcomes due to potential graft ischemia or underlying rhythmic/structural defects. However, selected grafts from ... Full text Link to item Cite

The Future of heart procurement with donation after circulatory death: Current practice and opportunities for advancement.

Journal Article J Heart Lung Transplant · October 2022 Heart Donation after Circulatory Death (DCD) has the potential to significantly increase the number of patients benefitting from heart transplantation. However, the expansion of DCD heart transplantation is currently limited by unanswered questions pertain ... Full text Link to item Cite

Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases.

Journal Article J Heart Lung Transplant · October 2022 We present our institution's protocol for evaluating and transplanting thoracic organs from COVID-19 positive donors and report the outcomes to date. Hearts from donors testing positive for COVID-19 on any test were eligible for transplantation at our inst ... Full text Link to item Cite

Predictive capabilities of the European registry for patients with mechanical circulatory support right-sided heart failure risk score after left ventricular assist device implantation.

Journal Article J Cardiothorac Vasc Anesth · October 2022 OBJECTIVES: The prediction of right heart failure (RHF) after left ventricular assist device (LVAD) implantation remains a challenge. Recently, risk scores were derived from analysis of the European Registry for Patients with Mechanical Circulatory Support ... Full text Link to item Cite

Donation After Circulatory Death in Heart Transplantation: History, Outcomes, Clinical Challenges, and Opportunities to Expand the Donor Pool.

Journal Article J Card Fail · September 2022 Heart transplantation remains the gold-standard therapy for end-stage heart failure; the expected median survival range is 12-13 years. More than 30,000 heart transplants have been performed globally in the past decade alone. With advances in medical and s ... Full text Link to item Cite

Primary Graft Dysfunction after Heart Transplantation - Unravelling the Enigma.

Journal Article Curr Probl Cardiol · August 2022 Primary graft dysfunction (PGD) remains the main cause of early mortality following heart transplantation despite several advances in donor preservation techniques and therapeutic strategies for PGD. With that aim of establishing the aetiopathogenesis of P ... Full text Link to item Cite

Relationship between donor fraction cell-free DNA and clinical rejection in heart transplantation.

Journal Article Pediatr Transplant · June 2022 BACKGROUND: Clinical rejection (CR) defined as decision to treat clinically suspected rejection with change in immunotherapy based on clinical presentation with or without diagnostic biopsy findings is an important part of care in heart transplantation. We ... Full text Link to item Cite

Progression of aortic valve insufficiency during centrifugal versus axial flow left ventricular assist device support.

Journal Article Eur J Cardiothorac Surg · May 2, 2022 OBJECTIVES: Long-term left ventricular assist device (LVAD) support can cause accelerated progression of aortic insufficiency (AI). The MOMENTUM trial has led to increased use of the HeartMate 3 (HM3) LVAD, due to greater hemocompatibility. However, the di ... Full text Link to item Cite

Incidence and Diagnostic Challenges of Bowel Ischemia after Continuous-flow Left Ventricular Assist Device Therapy.

Journal Article ASAIO J · May 1, 2022 Long-term continuous-flow left ventricular assist device (CFLVAD) therapy is limited by complications. Compared with stroke and renal dysfunction, post-CFLVAD bowel ischemia is poorly characterized. Adult patients who underwent first-time durable CFLVAD im ... Full text Link to item Cite

Innovations in Heart Transplantation: A Review.

Journal Article J Card Fail · March 2022 Advanced heart failure affects tens of thousands of people in the United States alone with high morbidity and mortality. Cardiac transplantation offers the best treatment strategy, but has been limited historically by donor availability. Recently, there ha ... Full text Link to item Cite

Right and left ventricular assist devices are an option for bridge to heart transplant.

Journal Article JTCVS Open · March 2022 BACKGROUND: Patients with a left ventricular assist device with right ventricular failure are prioritized on the heart transplant waitlist; however, their post-transplant survival is less well characterized. We aimed to determine whether pretransplant righ ... Full text Link to item Cite

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft.

Journal Article J Vis Exp · February 14, 2022 Cardiac transplantation is the gold standard treatment for end-stage heart failure. However, it remains limited by the number of available donor hearts and complications such as primary graft dysfunction and graft rejection. The recent clinical use of an e ... Full text Link to item Cite

Increase in nuclear cell-free DNA is associated with major adverse events in adult and pediatric heart transplant recipients.

Journal Article Clin Transplant · January 2022 BACKGROUND: Cell-free DNA is an emerging biomarker. While donor fraction may detect graft events in heart transplant recipients, the prognostic value of total nuclear cell-free DNA (ncfDNA) itself is largely unexplored. OBJECTIVE: Explore the relationship ... Full text Link to item Cite

Transplanting Thoracic COVID-19 Positive Donors: Overcoming the Pandemic

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

Trends in Substance Use in Patients Requiring Advanced Heart Failure Therapies

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

Transapical ProtekDuo Rapid Deployment Cannula as Temporary Left Ventricular Assist Device in a Jehovah's Witness Patient.

Journal Article J Cardiothorac Vasc Anesth · December 2021 Temporary left ventricular support aims to decompress the left ventricle and provide adequate forward flow into the arterial circulation. This can be accomplished with endovascular devices such as the Impella with an internal motor, or with the implementat ... Full text Link to item Cite

EXPANDing the Donor Pool: Quantifying the Potential Impact of a Portable Organ-Care System for Expanded Criteria Heart Donation.

Journal Article J Card Fail · December 2021 The recently concluded prospective Portable Organ Care System (OCS) Heart trial to Evaluate the Safety and Effectiveness of The Portable Organ Care System Heart for Preserving and Assessing Expanded Criteria Donor Hearts for Transplantation (EXPAND) demons ... Full text Link to item Cite

Proteomic profiling identifies CLEC4C expression as a novel biomarker of primary graft dysfunction after heart transplantation.

Journal Article J Heart Lung Transplant · December 2021 PURPOSE: Clinical models to identify patients at high risk of primary graft dysfunction (PGD) after heart transplantation (HT) are limited, and the underlying pathophysiology of this common post-transplant complication remains poorly understood. We sought ... Full text Link to item Cite

Activated Coagulation Time and Hepcon Protamine Titration Device to Manage Unfractionated Heparin During Cardiopulmonary Bypass in a Hemophilia A Patient on Emicizumab.

Journal Article J Cardiothorac Vasc Anesth · November 2021 In the perioperative management of patients with hemophilia A, emicizumab prevents the accurate measurement of common clotting assays, including the activated clotting time (ACT), which is essential for high-dose heparin monitoring during cardiopulmonary b ... Full text Open Access Link to item Cite

Curvularia alcornii Aortic Pseudoaneurysm Following Aortic Valve Replacement: Case Report and Review of the Literature.

Journal Article Open Forum Infect Dis · November 2021 We report the first case of Curvularia alcornii aortic pseudoaneurysm following bioprosthetic aortic valve replacement in an immunocompetent host. Infection was complicated by septic emboli to multiple organs. Despite aggressive surgical intervention and a ... Full text Open Access Link to item Cite

Electrical storm in patients with left ventricular assist devices: Risk factors, incidence, and impact on survival.

Journal Article Heart Rhythm · August 2021 BACKGROUND: Ventricular arrhythmias (VAs) and electrical storm (ES) are recognized complications following left ventricular assist device (LVAD) implantation; however, their association with long term-outcomes remains poorly understood. OBJECTIVE: The purp ... Full text Link to item Cite

Does deeper hypothermia reduce the risk of acute kidney injury after circulatory arrest for aortic arch surgery?

Conference Eur J Cardiothorac Surg · July 30, 2021 OBJECTIVES: The impact of hypothermic circulatory arrest (HCA) temperature on postoperative acute kidney injury (AKI) has not been evaluated. This study examined the association between circulatory arrest temperatures and AKI in patients undergoing proxima ... Full text Link to item Cite

A Case for Re-Gifting.

Journal Article JACC Case Rep · July 7, 2021 Many patients die while waiting for a heart transplant. Therefore, it is vital that all suitable organs are used for transplantation. We present a case of an allograft that was transplanted twice and outline considerations regarding tissue typing, the impa ... Full text Link to item Cite

Heart Transplantation Survival Outcomes of HIV Positive and Negative Recipients.

Journal Article Ann Thorac Surg · May 2021 BACKGROUND: In the era of antiretroviral therapy, HIV-positive patients have reduced mortality from HIV infection and increased morbidity from end-stage heart failure. The number of HIV-positive heart transplantation recipients remains scant. Long-term sur ... Full text Link to item Cite

Conventional Ultrafiltration During Elective Cardiac Surgery and Postoperative Acute Kidney Injury.

Journal Article J Cardiothorac Vasc Anesth · May 2021 OBJECTIVE: Conventional ultrafiltration (CUF) during cardiopulmonary bypass (CPB) serves to hemoconcentrate blood volume to avoid allogeneic blood transfusions. Previous studies have determined CUF volumes as a continuous variable are associated with posto ... Full text Open Access Link to item Cite

Invasive Mycobacterium abscessus Complex Infection After Cardiac Surgery: Epidemiology, Management, and Clinical Outcomes.

Journal Article Clin Infect Dis · April 8, 2021 BACKGROUND: We recently mitigated a clonal outbreak of hospital-acquired Mycobacterium abscessus complex (MABC), which included a large cluster of adult patients who developed invasive infection after exposure to heater-cooler units during cardiac surgery. ... Full text Link to item Cite

Mitigating the Impact of Using Female Donor Hearts in Male Recipients Using BMI Difference.

Journal Article Ann Thorac Surg · April 2021 BACKGROUND: Heart transplantation is limited by the supply of donor organs. Previous studies have associated female donor to male recipient with decreased posttransplant survival. We wanted to evaluate whether this risk can be mitigated using higher donor ... Full text Link to item Cite

OptiVol for Volume Assessment in Patients With Continuous Flow Left Ventricular Assist Device.

Journal Article ASAIO J · February 1, 2021 OptiVol (Medtronic PLC, Minneapolis, MN) is a diagnostic feature of some cardiac implantable electronic devices (CIEDs) based on changes in thoracic impedance (TI) over time. Changes in TI can predict heart failure (HF) hospitalizations and mortality in HF ... Full text Link to item Cite

PD-1 and PD-L1 expression in cardiac transplantation.

Journal Article Cardiovasc Pathol · 2021 Programmed death-ligand 1 (PD-L1), a transmembrane protein and member of the CD28 T cell family is associated with lymphocyte activation.1 PD-L1 expression is upregulated on activated antigen presenting cells such as monocytes, myeloid and dendritic cells. ... Full text Link to item Cite

Inhaled Selective Pulmonary Vasodilators for Advanced Heart Failure Therapies

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2021 Cite

Implantation of a HeartMate 3 ventricular assist device in a 21-kg pediatric patient with Fontan failure.

Journal Article J Card Surg · December 2020 AIMS: The HeartMate 3 (HM3) ventricular assist device (VAD) is gaining popularity in adults due to a favorable risk profile. However, reports of HM3 use in children are limited, potentially due to concerns with device size. MATERIALS AND METHODS: Here we r ... Full text Link to item Cite

Cardiovascular Implantable Electronic Device Surgery Following Left Ventricular Assist Device Implantation.

Journal Article JACC Clin Electrophysiol · September 2020 OBJECTIVES: This study sought to determine the indications, characteristics, and outcomes of cardiovascular implantable electronic device (CIED) surgery in patients with LVAD. BACKGROUND: Many patients with a left ventricular assist device (LVAD) will requ ... Full text Link to item Cite

Association between primary graft dysfunction and acute kidney injury after orthotopic heart transplantation - a retrospective, observational cohort study.

Journal Article Transpl Int · August 2020 Acute kidney injury (AKI) and primary graft dysfunction (PGD) are serious complications after heart transplantation (HT). The relationship between AKI and PGD is poorly understood. We sought to examine the incidence of AKI and identify risk factors associa ... Full text Link to item Cite

Early outcomes with durable left ventricular assist device replacement using the HeartMate 3.

Journal Article J Thorac Cardiovasc Surg · July 2020 BACKGROUND: The HeartMate 3 (HM3) left ventricular assist device (LVAD) (Abbott, Inc, Chicago, Ill) is a fully magnetically levitated centrifugal implantable pump used to treat patients with chronic heart failure. The MOMENTUM (Multicenter Study of MagLev ... Full text Link to item Cite

Safety and Feasibility of Simultaneous Transcarotid Revascularization With Flow Reversal and Coronary Artery Bypass Grafting for Concomitant Carotid Artery Stenosis and Coronary Artery Disease.

Journal Article Vasc Endovascular Surg · July 2020 OBJECTIVE: The management of patients with combined severe carotid artery and coronary artery disease (CAD) is controversial. Transcarotid stenting with flow reversal (TCAR) is a novel hybrid technique for carotid revascularization. We sought to investigat ... Full text Link to item Cite

Reassessing Recipient Mortality Under the New Heart Allocation System: An Updated UNOS Registry Analysis.

Journal Article JACC Heart Fail · July 2020 BACKGROUND: An early report of recipient heart transplantation outcomes under the new U.S. heart allocation system introduced in late 2018 found a lower post-transplant survival rate compared with that of the prior system. OBJECTIVES: The aim of this study ... Full text Link to item Cite

Implantable cardioverter-defibrillator lead revision following left ventricular assist device implantation.

Journal Article J Cardiovasc Electrophysiol · June 2020 INTRODUCTION: Lead dysfunction can lead to serious consequences including failure to treat ventricular tachycardia or fibrillation (VT/VF). The incidence and mechanisms of lead dysfunction following left ventricular assist device (LVAD) implantation are no ... Full text Link to item Cite

Transplant Center Variability in Organ Offer Acceptance and Mortality Among US Patients on the Heart Transplant Waitlist.

Journal Article JAMA Cardiol · June 1, 2020 IMPORTANCE: Under the current Centers for Medicare & Medicaid Services guidelines, there is incentivization to optimize posttransplant outcomes regardless of mortality among patients on the waitlist and transplant rates; few data exist with regard to trans ... Full text Link to item Cite

Lead Extraction for Cardiovascular Implantable Electronic Device Infection in Patients With Left Ventricular Assist Devices.

Journal Article JACC Clin Electrophysiol · June 2020 OBJECTIVES: The goal of this study was to assess the utility of transvenous lead extraction for cardiovascular implantable electronic device (CIED) infection in patients with a left ventricular assist device (LVAD). BACKGROUND: The use of transvenous lead ... Full text Link to item Cite

Donor fraction cell-free DNA and rejection in adult and pediatric heart transplantation.

Journal Article J Heart Lung Transplant · May 2020 BACKGROUND: Endomyocardial biopsy (EMB) is the current standard for rejection surveillance in heart transplant recipients. The quantification of donor-specific cell-free DNA (cfDNA) may be an appropriate biomarker for non-invasive rejection surveillance. A ... Full text Link to item Cite

A Minimally Invasive Approach to HeartMate 3 Implantation for Systemic Ventricular Failure Following the Mustard Procedure for Transposition of the Great Arteries.

Journal Article ASAIO J · April 2020 Late systemic (right) ventricular failure is common after the Mustard procedure for transposition of the great arteries (TGA), and mechanical circulatory support may be required for patients presenting with refractory heart failure; however, clinical exper ... Full text Link to item Cite

Association of Clinical Outcomes With Left Ventricular Assist Device Use by Bridge to Transplant or Destination Therapy Intent: The Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy With HeartMate 3 (MOMENTUM 3) Randomized Clinical Trial.

Journal Article JAMA Cardiol · April 1, 2020 IMPORTANCE: Left ventricular assist devices (LVADs) are well established in the treatment of advanced heart failure, but it is unclear whether outcomes are different based on the intended goal of therapy in patients who are eligible vs ineligible for heart ... Full text Link to item Cite

Association of postoperative complications and outcomes following coronary artery bypass grafting.

Journal Article Am Heart J · April 2020 BACKGROUND: The long-term effects of postoperative complications following coronary artery bypass grafting (CABG) are unknown. METHODS: Medicare-linked records from the Society of Thoracic Surgeons Adult Cardiac Surgery Database were queried for isolated C ... Full text Link to item Cite

Successful Gene Delivery to Cardiac Allograft with Adeno-Associated Viral Vector Using Ex Vivo Storage Perfusion Platform

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Cardiac gene therapy remains limited by inefficient transgene delivery with currently available methods (intravenous infusion, transcatheter coronary artery infusion, direct myocardial injection). We previously demonstrated in a porcine heterotopi ... Full text Cite

Impact of Tricuspid Valve Repair for Moderate Tricuspid Regurgitation at the Time of Left Ventricular Assist Device Implantation on the Occurrence of Right Heart Failure

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Significant tricuspid regurgitation (TR) in patients undergoing durable left ventricular assist device (LVAD) implantation has been associated with increased incidence of right heart failure (RHF). There is great surgical practice variability rela ... Full text Cite

EUROMACS-RHF Risk Score and 3D Echocardiography as Predictors of Right Heart Failure after Left Ventricular Assist Device Implantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Right heart failure (RHF) after LVAD implantation is associated with significant morbidity and mortality. Recently, the EUROMACS-RHF risk score was developed to predict postoperative RHF in this setting. In a single-center analysis, we assessed th ... Full text Cite

Pre-Formed Donor-Specific Antibodies Impact Long Term Survival of Heart Transplants

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: We previously reported that heart transplant (HTx) recipients with pre-formed, anti-HLA antibodies at low titer had one-year survival that was comparable to patients without any anti-HLA antibodies. As a result, we defined unacceptable HLA antigen ... Full text Cite

More Money and More Miles: The Hidden Costs of Donor Procurement with the New Heart Allocation System

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: In October 2018, the United Network for Organ Sharing (UNOS) implemented extensive changes to the adult heart allocation policy. These changes were developed to better stratify medically urgent patients and provide more equitable geographic distri ... Full text Cite

Clinical Outcomes and Quality of Life With an Ambulatory Counterpulsation Pump in Advanced Heart Failure Patients: Results of the Multicenter Feasibility Trial.

Journal Article Circ Heart Fail · April 2020 BACKGROUND: The NuPulseCV intravascular ventricular assist system (iVAS) provides extended duration ambulatory counterpulsation via a durable pump placed through the distal subclavian artery. METHODS: We performed a prospective, single-arm, multicenter, US ... Full text Link to item Cite

The HeartMate 6.

Journal Article ASAIO J · March 2020 The need for biventricular support poses significant challenges for patients who require a mechanical bridge to transplantation. Recent improvements in ventricular assist device (VAD) technology has made possible the use of two centrifugal flow VADs as a t ... Full text Link to item Cite

Valve-in-Ring Transcatheter Aortic Valve Replacement After Left Ventricular Assist Device Therapy.

Journal Article Ann Thorac Surg · March 2020 Aortic regurgitation after left ventricular assist device (LVAD) implantation is a well-described problem that decreases the clinical effectiveness of LVAD therapy and may eventually prompt consideration of aortic valve replacement once the regurgitation b ... Full text Link to item Cite

Percutaneous Intervention for Left Ventricular Assist Device Outflow Obstruction.

Journal Article Heart Lung Circ · March 2020 Left ventricular assist devices (LVADs) are used to support patients with advanced systolic heart failure (HF). These patients might develop LVAD dysfunction and consequent HF symptoms. Occasionally, outflow graft obstruction is responsible for LVAD dysfun ... Full text Link to item Cite

LVAD Outflow Graft Role in Pump Thrombosis.

Journal Article ASAIO J · February 2020 Left ventricular assist devices are (LVAD) used for circulatory support in patients with end-stage heart failure. Hemolysis/pump dysfunction is a well-known complication of this therapy with various etiologic causes. A small proportion of these complicatio ... Full text Link to item Cite

Stroke risk following implantation of current generation centrifugal flow left ventricular assist devices.

Journal Article J Card Surg · February 2020 BACKGROUND AND AIM: Stroke remains a significant complication of left ventricular assist device (LVAD) therapy. We performed a single-center retrospective study evaluating patients undergoing first-time HeartWare HVAD (Medtronic Inc) or HeartMate 3 (Abbott ... Full text Link to item Cite

Durability and Efficacy of Tricuspid Valve Repair in Patients Undergoing Left Ventricular Assist Device Implantation.

Journal Article JACC Heart Fail · February 2020 OBJECTIVES: This study sought to determine the durability of tricuspid valve repair (TVr) performed concurrently with left ventricular assist device (LVAD) implantation and its association with the development of late right heart failure (RHF). BACKGROUND: ... Full text Open Access Link to item Cite

Planned right ventricular support for combined heart-liver transplantation.

Journal Article Interact Cardiovasc Thorac Surg · December 1, 2019 Right ventricular dysfunction post heart transplantation (HTx) is a common problem and its likelihood to occur after combined heart-liver transplantation is even higher. The placement of an extracorporeal planned right ventricular assist device following t ... Full text Link to item Cite

Simultaneous transcarotid artery revascularization with flow reversal and coronary artery bypass grafting: A novel hybrid technique.

Conference J Vasc Surg Cases Innov Tech · December 2019 Optimal management of concomitant coronary artery disease and carotid artery stenosis remains unknown. Current treatment strategies for patients with significant dual disease burden include simultaneous carotid endarterectomy and coronary artery bypass gra ... Full text Link to item Cite

Heart Transplantation Survival and the Use of Traumatically Brain-Injured Donors: UNOS Registry Propensity-Matched Analysis.

Journal Article J Am Heart Assoc · September 3, 2019 Background The transplantation of hearts from traumatically brain-injured (TBI) donors has been associated with inferior long-term survival in single-center analyses. However, in a more recent analysis, death caused by cerebrovascular accident was associat ... Full text Link to item Cite

Controlling axillary intra-aortic balloon pump inflation is a viable option for turning an acute heart failure patient into a chronic one.

Journal Article Artif Organs · July 2019 Intra-aortic balloon pump (IABP) is often used to support patients in decompensated heart failure. Placement of the IABP via the axillary artery facilitates long-term support with the device and may allow for the conversion of an acute heart failure (HF) p ... Full text Link to item Cite

Outcomes After Extracorporeal Right Ventricular Assist Device Combined With Durable Left Ventricular Assist Device Support.

Journal Article Ann Thorac Surg · June 2019 BACKGROUND: Right heart failure occurs in 9% to 44% of left ventricular assist device (LVAD) implants, of which less than 10% require right ventricular assist device (RVAD) support either concurrently with the LVAD or staged, as a delayed procedure. We hav ... Full text Link to item Cite

A normothermic ex vivo organ perfusion delivery method for cardiac transplantation gene therapy.

Journal Article Sci Rep · May 29, 2019 Clinically, both percutaneous and surgical approaches to deliver viral vectors to the heart either have resulted in therapeutically inadequate levels of transgene expression or have raised safety concerns associated with extra-cardiac delivery. Recent deve ... Full text Link to item Cite

Frailty in the End-Stage Lung Disease or Heart Failure Patient: Implications for the Perioperative Transplant Clinician.

Journal Article J Cardiothorac Vasc Anesth · May 2019 The syndrome of frailty for patients undergoing heart or lung transplantation has been a recent focus for perioperative clinicians because of its association with postoperative complications and poor outcomes. Patients with end-stage cardiac or pulmonary f ... Full text Open Access Link to item Cite

Tricuspid Valve Regurgitation Immediately After Heart Transplant and Long-Term Outcomes.

Journal Article Ann Thorac Surg · May 2019 BACKGROUND: Tricuspid valve regurgitation (TR) is a common finding immediately after cardiac transplantation. However, there is a scarcity of data regarding its implication if left untreated on long-term outcomes and the role of early surgical repair. METH ... Full text Link to item Cite

Outcomes of Laparoscopic Cholecystectomy in Patients Supported with a Left Ventricular Assist Device.

Journal Article J Laparoendosc Adv Surg Tech A · April 2019 BACKGROUND: An increasing number of end-stage heart failure patients are supported with left ventricular assist device (LVAD) implantation and must be maintained on consistent anticoagulation. These patients are experiencing prolonged survival and, in some ... Full text Link to item Cite

Hepatitis and Thoracic Transplantation - No More Virus Non-Grata

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

HeartMate 3 Surgical Implant Technique and Outcomes in the MOMENTUM 3 Trial

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Temporary autonomic modulation with botulinum toxin type A to reduce atrial fibrillation after cardiac surgery.

Journal Article Heart Rhythm · February 2019 BACKGROUND: Postoperative atrial fibrillation (POAF) frequently complicates cardiac surgery and is associated with worse outcomes. The cardiac autonomic nervous system is implicated in the pathogenesis of POAF. OBJECTIVE: The purpose of this study was to d ... Full text Link to item Cite

Transplanting a heart with a persistent left superior vena cava.

Journal Article J Thorac Cardiovasc Surg · February 2019 Full text Link to item Cite

Evaluation of the safety and efficacy of a new hemostatic powder using a quantitative surface bleeding severity scale.

Journal Article J Card Surg · January 2019 AIMS OF THE STUDY: The safety and efficacy of a hemostatic powder (HP) versus a control agent, absorbable gelatin sponge and thrombin (G + T), were assessed, using a validated, quantitative bleeding severity scale. METHODS: Subjects were randomized to rece ... Full text Link to item Cite

Management of Patients With Left Ventricular Assist Devices Requiring Teeth Extraction: Is Halting Anticoagulation Appropriate?

Journal Article J Oral Maxillofac Surg · September 2018 PURPOSE: An increasing number of patients with end-stage heart failure are supported with left ventricular assist device (LVAD) implantation and must be maintained on a consistent anticoagulation regimen. Pre-emptive extraction of carious teeth in these pa ... Full text Link to item Cite

Primary graft dysfunction after heart transplantation: Incidence, trends, and associated risk factors.

Journal Article Am J Transplant · June 2018 Changes in heart transplantation (HT) donor and recipient demographics may influence the incidence of primary graft dysfunction (PGD). We conducted a retrospective study to evaluate PGD incidence, trends, and associated risk factors by analyzing consecutiv ... Full text Link to item Cite

Risk factors for stroke on left ventricular assist devices.

Journal Article J Card Surg · June 2018 BACKGROUND: Patients with end-stage heart failure on left ventricular assist devices (LVADs) are predisposed to a high incidence of stroke. Preoperative factors associated with increased stroke risk are poorly understood. METHODS: We performed a single-cen ... Full text Link to item Cite

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart.

Journal Article J Vis Exp · May 11, 2018 Mechanical circulatory support (MCS) has been introduced as a viable alternative to heart transplantation primarily through the use of intracorporeal ventricular assist devices (VADs) for support of the left ventricle. However, certain clinical scenarios w ... Full text Link to item Cite

Trends and outcomes of cardiac transplantation from donors dying of drug intoxication.

Journal Article Am Heart J · May 2018 BACKGROUND: Deaths from drug intoxication have increased in the United States but outcomes of recipients of orthotopic heart transplantation (OHT) from these donors are not well characterized. METHODS: We performed a retrospective analysis of the United Ne ... Full text Link to item Cite

Using a Regent Aortic Valve in a Small Annulus Mitral Position Is a Viable Option.

Journal Article Ann Thorac Surg · April 2018 BACKGROUND: Outcome of mitral valve replacement in extreme scenarios of small mitral annulus with the use of the Regent mechanical aortic valve is not well documented. METHODS: Records were examined in 31 consecutive patients who underwent mitral valve rep ... Full text Open Access Link to item Cite

Robot-assisted repair of diaphragmatic hernias following ventricular assist device implantation.

Journal Article J Surg Case Rep · February 2018 Use of ventricular assist devices (VADs) is increasingly common, as is the need for surgeons to be familiar with the management of common complications in this population. Nonetheless, repair of diaphragmatic hernias which commonly develop following VAD im ... Full text Link to item Cite

Allogeneic Mesenchymal Stem Cells for Treatment of AKI after Cardiac Surgery.

Journal Article J Am Soc Nephrol · January 2018 AKI after cardiac surgery remains strongly associated with mortality and lacks effective treatment or prevention. Preclinical studies suggest that cell-based interventions may influence functional recovery. We conducted a phase 2, randomized, double-blind, ... Full text Link to item Cite

Pre- and postoperative anemia, acute kidney injury, and mortality after coronary artery bypass grafting surgery: a retrospective observational study.

Journal Article Can J Anaesth · January 2018 BACKGROUND: Preoperative and postoperative anemia have been identified individually as potential risk factors for postoperative complications after coronary artery bypass grafting (CABG) surgery. Their interrelationship with acute kidney injury (AKI) and l ... Full text Link to item Cite

Heartmate III Replacement for Recurring Left Ventricular Assist Device Pump Thrombosis.

Journal Article ASAIO J · 2018 Left ventricular assist devices (LVADs) are being used widely to support patients with advanced systolic heart failure. Some of these patients will need more than one LVAD replacement due to pump thrombosis. The Heartmate III LVAD (Abbott Inc, Chicago, IL) ... Full text Link to item Cite

Migration of Intraaortic Balloon Pump Placed Via the Axillary Artery.

Journal Article J Invasive Cardiol · January 2018 Axillary artery intraaortic balloon pump (IABP) placement enables those awaiting transplant to ambulate and get stronger, but motion increases risk of IABP migration. The management of a migrated pump in a 44-year-old man with heart failure is described. ... Link to item Cite

Estimation of Achievable Oxygen Consumption Following Transfusion With Rejuvenated Red Blood Cells.

Journal Article Semin Thorac Cardiovasc Surg · 2018 Erythrocyte storage induces a nonphysiological increase in hemoglobin-oxygen affinity (quantified by low p50, the oxygen tension at 50% hemoglobin saturation), which can be restored through biochemical rejuvenation. The objective was to mathematically mode ... Full text Link to item Cite

A tale of two centrifugal left ventricular assist devices.

Journal Article J Thorac Cardiovasc Surg · September 2017 Full text Link to item Cite

Elective Venovenous Extracorporeal Membrane Oxygenation for Resection of Endotracheal Tumor: A Case Report.

Journal Article A A Case Rep · August 15, 2017 We present a case in which we electively used venovenous extracorporeal membrane oxygenation (VV-ECMO) to facilitate safe resection of a nearly obstructing airway tumor near the carina in a 37-year-old male. The patient was brought to the operating room an ... Full text Link to item Cite

Breaking Bad: The Heartbreak of Drug Abuse.

Journal Article JACC Heart Fail · June 2017 Full text Link to item Cite

Postoperative management of heart transplantation patients.

Journal Article Best Pract Res Clin Anaesthesiol · June 2017 Heart transplant recipients are at risk for a number of post-transplantation complications such as graft dysfunction, rejection, and infection. The rates of many complications are decreasing over time, and prognosis is improving. However, these patients co ... Full text Link to item Cite

Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation.

Journal Article Clin Infect Dis · April 1, 2017 BACKGROUND: Nontuberculous mycobacteria (NTM) commonly colonize municipal water supplies and cause healthcare-associated outbreaks. We investigated a biphasic outbreak of Mycobacterium abscessus at a tertiary care hospital. METHODS: Case patients had recen ... Full text Link to item Cite

Mycobacterium Abscessus Infection in Patients with Ventricular Assist Devices

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · April 1, 2017 Link to item Cite

Invasive Mycobacterium abscessus Infection in Heart Transplant Recipients

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · April 1, 2017 Link to item Cite

Rethinking papillary muscle resection for refractory ventricular tachycardia in the LVAD era. A case report.

Journal Article J Electrocardiol · 2017 We report the case of a 57-year-old man with a history of ischemic cardiomyopathy who presented to the hospital with recurrent episodes of ventricular tachycardia refractory to antiarrhythmic medications. Mapping identified a deep premature ventricular con ... Full text Link to item Cite

The Axillary Intra-Aortic Balloon Pump as a Bridge to Recovery Allows Early Ambulation in Long-Term Use: Case Series and Literature Review.

Journal Article Innovations (Phila) · 2017 We evaluated the feasibility, tolerability, and efficacy of a strategy for transaxillary artery intra-aortic balloon pump placement for extended mechanical circulatory support of patients with postcardiotomy shock as a bridge to recovery. Patients requirin ... Full text Link to item Cite

Trends and outcomes of patients with adult congenital heart disease and pulmonary hypertension listed for orthotopic heart transplantation in the United States.

Journal Article J Heart Lung Transplant · May 2016 BACKGROUND: Heart transplantation is increasing in patients with adult congenital heart disease (ACHD). In this population, the association of pulmonary hypertension (PH) with post-transplant outcomes is not well-defined. METHODS: Using data from the Unite ... Full text Link to item Cite

The utility of the aortic dissection team: outcomes and insights after a decade of experience.

Journal Article Ann Cardiothorac Surg · May 2016 BACKGROUND: Mortality rates following acute type A aortic dissection (ATAAD) repair are reduced when operations are performed by a high-volume acute aortic dissection (AAD) team, leading to efforts to centralize ATAAD care. Here, we describe our experience ... Full text Link to item Cite

Elevated Cardiac Troponin I in Preservation Solution Is Associated With Primary Graft Dysfunction.

Journal Article J Card Fail · February 2016 BACKGROUND: Although primary graft dysfunction (PGD) is a leading cause of mortality and morbidity early post-heart transplant, relatively little is known regarding mechanisms involved in PGD development. METHODS AND RESULTS: We examined the relationship b ... Full text Link to item Cite

Early Experience with a Novel Cannulation Strategy for Left Ventricular Decompression during Nonpostcardiotomy Venoarterial ECMO.

Journal Article ASAIO J · 2016 Advances in technology for the delivery of venoarterial extracorporeal membrane oxygenation (VA-ECMO) have allowed for its expanded utilization in the treatment of patients with advanced cardiogenic shock, particularly through the use of peripheral cannula ... Full text Link to item Cite

Prolonged pulmonary support after cardiac surgery: incidence, risk factors and outcomes: a retrospective cohort study.

Journal Article J Crit Care · October 2015 BACKGROUND: Post-cardiac surgery pulmonary dysfunction may be underreported. Therefore, we evaluated associated risk factors for prolonged pulmonary support after cardiac surgery. METHODS AND MATERIALS: We conducted a retrospective, observational study of ... Full text Link to item Cite

Scedosporium apiosermum infection of the "Native" valve: Fungal endocarditis in an orthotopic heart transplant recipient.

Journal Article Med Mycol Case Rep · September 2015 Scedosporium apiospermum is an increasingly appreciated pathogen in immunosuppressed patients. We present a case of S. apiospermum endocarditis in a 70-year-old male who had undergone orthotopic heart transplant. Echocardiogram demonstrated a 1.4 cm tricus ... Full text Link to item Cite

Comparison of 2-Year Outcomes of Extended Criteria Cardiac Transplantation Versus Destination Left Ventricular Assist Device Therapy Using Continuous Flow.

Journal Article Am J Cardiol · August 15, 2015 Alternatives have emerged for patients ineligible for cardiac transplantation under standard criteria. The purpose of our study was to compare outcomes in patients ineligible for cardiac transplantation under standard criteria, treated either with extended ... Full text Link to item Cite

Bridge to long-term mechanical circulatory support with a left ventricular assist device: novel use of transcatheter aortic valve replacement.

Journal Article Ann Thorac Surg · April 2015 We describe the use of transcatheter aortic valve replacement to allow for bridging to a left ventricular assist device in a patient with end-stage heart failure, secondary to nonischemic cardiomyopathy and severe bioprosthetic aortic valve regurgitation. ... Full text Link to item Cite

Total Artificial Heart Replacement With 2 Centrifugal Blood Pumps

Journal Article Operative Techniques in Thoracic and Cardiovascular Surgery · February 3, 2015 A total of 2 small, electrical, centrifugal pumps can be implanted as a total artificial heart replacement. This type of mechanical support may be advantageous in the setting of severe biventricular failure when cannulation of the native ventricles is comp ... Full text Cite

Preprocedural ECG-gated computed tomography for prevention of complications during lead extraction.

Journal Article Pacing Clin Electrophysiol · October 2014 BACKGROUND: Preprocedural multidetector computed tomography (MDCT) may identify patients at risk for mechanical complications during lead extraction. METHODS: To describe the use and feasibility of computed tomography scanning for preprocedural planning of ... Full text Link to item Cite

Dysphagia in the setting of left ventricular assist device hemolysis.

Journal Article ASAIO J · 2013 A 69-year-old man with advanced heart failure treated with a continuous-flow left ventricular assist device presented for evaluation of dark urine and severe dysphagia. Because of evidence of ongoing intravascular hemolysis with device dysfunction, there w ... Full text Link to item Cite

X-linked inhibitor of apoptosis protein-mediated attenuation of apoptosis, using a novel cardiac-enhanced adeno-associated viral vector.

Journal Article Hum Gene Ther · June 2012 Successful amelioration of cardiac dysfunction and heart failure through gene therapy approaches will require a transgene effective at attenuating myocardial injury, and subsequent remodeling, using an efficient and safe delivery vehicle. Our laboratory ha ... Full text Link to item Cite

Mallory-weiss syndrome

Chapter · December 1, 2010 Mallory and Weiss first described gastroesophageal tears causing gastrointestinal bleeding in 15 alcoholic patients in 1929 [1]. Since this time, longitudinal mucosal lacerations, associated with forceful retching, has become a well-known cause of upper ga ... Full text Cite

Midterm results for endovascular repair of complicated acute and chronic type B aortic dissection.

Journal Article Ann Thorac Surg · January 2010 BACKGROUND: Thoracic endovascular aortic repair (TEVAR) for the management of type B aortic dissections has become more commonplace despite some controversy. Results of endovascular management of complicated acute (<2 weeks from symptom onset) and chronic ... Full text Link to item Cite

Dynamic regulation of phosphoinositide 3-kinase-gamma activity and beta-adrenergic receptor trafficking in end-stage human heart failure.

Journal Article Circulation · November 27, 2007 BACKGROUND: Downregulation of beta-adrenergic receptors (betaARs) under conditions of heart failure requires receptor targeting of phosphoinositide 3-kinase (PI3K)-gamma and redistribution of betaARs into endosomal compartments. Because support with a left ... Full text Link to item Cite

Heparin-induced thrombocytopenia in left ventricular assist device bridge-to-transplant patients.

Journal Article Ann Thorac Surg · September 2007 BACKGROUND: The presence of heparin-induced thrombocytopenia (HIT) increases the risk for thromboembolic events in ventricular assist device (VAD) patients undergoing transplantation. However, cardiopulmonary bypass with alternative anticoagulants is often ... Full text Link to item Cite

Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading.

Journal Article J Card Fail · June 2006 BACKGROUND: In human heart failure, increased expression of G protein-coupled receptor kinases (GRKs) causes the loss of beta-adrenergic receptor (betaAR) signaling and function. Mechanical unloading with a left ventricular assist device (LVAD) promotes re ... Full text Link to item Cite

Cardiac transplantation following ACORN CorCap device implantation.

Journal Article Eur J Cardiothorac Surg · May 2006 Passive ventricular restraint devices, such as the ACORN CorCap, have been introduced as a potential therapy for congestive heart failure (CHF). These mesh devices act as a mechanical support for the dilated heart. Due to incorporation of the device to the ... Full text Link to item Cite

Risk-adjusted short- and long-term outcomes for on-pump versus off-pump coronary artery bypass surgery.

Journal Article Circulation · August 30, 2005 BACKGROUND: Surgeons have adopted off-pump coronary artery bypass grafting (OPCAB) in an effort to reduce the morbidity of surgical revascularization. However, long-term outcome of OPCAB compared with conventional coronary artery bypass grafting (CABG) rem ... Full text Link to item Cite

Impact of mitral valve regurgitation evaluated by intraoperative transesophageal echocardiography on long-term outcomes after coronary artery bypass grafting.

Journal Article Circulation · August 30, 2005 BACKGROUND: It is unclear if mild or moderate mitral valve regurgitation (MR) should be repaired at the time of coronary artery bypass grafting (CABG). We sought to determine the long-term effect of uncorrected MR, measured by intraoperative transesophagea ... Full text Link to item Cite

Modulation of phosphatidylinositol 3-kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts.

Journal Article J Thorac Cardiovasc Surg · June 2005 OBJECTIVES: Fifty percent of human aortocoronary saphenous vein grafts are occluded after 10 years. Intimal hyperplasia is an initial step in graft occlusion and consists of vascular smooth muscle cell proliferation. Phosphatidylinositol 3-kinase and its d ... Full text Link to item Cite

Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex.

Journal Article Circulation · May 24, 2005 BACKGROUND: Desensitization and downregulation of myocardial beta-adrenergic receptors (betaARs) are initiated by the increase in betaAR kinase 1 (betaARK1) levels. By interacting with betaARK1 through the phosphoinositide kinase (PIK) domain, phosphoinosi ... Full text Link to item Cite

Gene delivery approaches to heart failure treatment.

Journal Article Expert Opin Biol Ther · September 2004 Heart failure remains a leading cause of worldwide morbidity and mortality. Despite recent advances in treatment and our increasing knowledge of pathophysiology and the molecular derangements involved in the failing heart, our ability to affect the underly ... Full text Link to item Cite

Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts.

Journal Article Circulation · April 6, 2004 BACKGROUND: Failing human myocardium is characterized by an attenuated contractile response to beta-adrenergic receptor (betaAR) stimulation due to changes in this signaling cascade, including increased expression and activity of the beta-adrenergic recept ... Full text Link to item Cite

Central Cannulation as a Viable Alternative to Peripheral Cannulation in Extracorporeal Membrane Oxygenation.

Journal Article Semin Thorac Cardiovasc Surg Arterial cannulation for veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) is most commonly established via the aorta, axillary, or femoral vessels, yet their inherent complications are not well characterized. The purpose of this study was to c ... Full text Link to item Cite

Interhospital ECMO Transport: Regional Focus.

Journal Article Semin Thorac Cardiovasc Surg Utilization of extracorporeal membrane oxygenation (ECMO) has increased dramatically over the last decade. Despite this trend, many medical centers have limited, if any, access to this technology or the resources necessary to manage these complex patients. ... Full text Link to item Cite