Scholars@Duke
Laura Horst Rosenberger

Laura Horst Rosenberger

Associate Professor of Surgery
Surgical Oncology
laura.rosenberger@duke.edu
Duke University Medical Center, Box 3513, Durham, NC 27710

Selected Publications

Utility of the Singapore recurrence nomogram in a US cohort with a higher proportion of borderline and malignant phyllodes tumours.

Journal Article J Clin Pathol · October 17, 2025 AIMS: For phyllodes tumours (PT), local and distant recurrence rates increase with higher grades and are difficult to predict. The Singapore nomogram has been used to predict recurrence events for PT. We aimed to test this nomogram for accuracy in a US coh ... Full text Link to item Cite

Surgical Considerations for Patients With de Novo Metastatic Breast Cancer Based on Prognostic Group.

Journal Article J Surg Res · October 9, 2025 INTRODUCTION: Advances in systemic therapy for de novo metastatic breast cancer (dnMBC) led to the development of a novel staging system (IVA-D), which stratifies patients into prognostic subgroups based on tumor characteristics and metastatic extent. Over ... Full text Link to item Cite

Circulating Tumor DNA (ctDNA) is Reliably Detected in Patients with Metastatic Malignant Phyllodes Tumors, a Feasibility Study.

Journal Article Ann Surg Oncol · October 2025 BACKGROUND: Malignant phyllodes tumors (MPT) are biologically aggressive breast neoplasms, with high local and distant recurrence rates and a median survival of 12 months when metastatic. With a disease-free interval often less than 2 years, circulating tu ... Full text Link to item Cite

Neoadjuvant Chemotherapy is Not Associated with Improved Overall Survival in Metaplastic Breast Cancer Regardless of Tumor Subtype.

Journal Article Ann Surg Oncol · October 2025 INTRODUCTION: Metaplastic breast cancer (MpBC) is a rare breast cancer subtype historically less responsive to neoadjuvant chemotherapy (NAC), regardless of receptor status. Given increasing NAC administration in recent years, we analyzed contemporary trea ... Full text Link to item Cite

Contemporary Trends in Axillary Surgery for ER-Positive, HER2-Negative Breast Cancer Stratified by Neoadjuvant Endocrine Therapy, Neoadjuvant Chemotherapy, or Upfront Surgery.

Journal Article Ann Surg Oncol · September 23, 2025 BACKGROUND: De-escalation of axillary surgery for hormone receptor-positive breast cancer has gained traction, but guidelines for axillary management after neoadjuvant endocrine therapy (NET) remain ill-defined. METHODS: Female patients age ≥50 years with ... Full text Link to item Cite

Neoadjuvant Endocrine Therapy Use in Estrogen Receptor Positive Breast Cancer: Insights from Practice Shifts During the COVID-19 Pandemic.

Journal Article Ann Surg Oncol · September 20, 2025 BACKGROUND: The COVID-19 pandemic restricted operating room availability, prompting the Pandemic Breast Cancer Consortium to issue guidelines on deferring non-urgent surgical procedures. This led to an increased use of neoadjuvant endocrine therapy (NET) f ... Full text Link to item Cite

A Multi-Institutional Analysis of Contralateral Axillary Metastases: Advanced Local-Regional Disease Divergent from Stage IV Breast Cancer.

Journal Article Ann Surg Oncol · August 2025 BACKGROUND: Contralateral axillary metastasis (CAM) is a rare event and is considered stage IV disease. We sought to evaluate outcomes in a CAM cohort treated with curative intent and contemporary systemic and locoregional therapy. PATIENTS AND METHODS: A ... Full text Link to item Cite

Adjuvant Radiation vs Endocrine Therapy After Lumpectomy for Early-Stage Breast Cancer in Older Women: Analysis of Real-World Survival Outcomes.

Journal Article Ann Surg Oncol · June 6, 2025 BACKGROUND: We examined whether adjuvant radiation therapy (RT) monotherapy offers comparable overall survival (OS) to adjuvant endocrine therapy (ET) monotherapy following lumpectomy in women aged ≥ 65 years with favorable early stage breast cancer. PATIE ... Full text Link to item Cite

ERBB2-Low Expression by Race and Ethnicity Among Patients With Triple-Negative Breast Cancer.

Journal Article JAMA Netw Open · June 2, 2025 IMPORTANCE: Racial and ethnic disparities in pathologic complete response (pCR) and overall survival (OS) have been reported in patients with triple-negative breast cancer (TNBC). In addition to socioeconomic factors and access to care, differences in tumo ... Full text Link to item Cite

High risk surveillance MRI may not be necessary in BRCA1/2 mutation carriers over 70 years old.

Journal Article Breast Cancer Res Treat · June 2025 BACKGROUND: The risk of developing breast cancer up to age 80 for women with BRCA1/2 mutations is approximately 69-72%. The risk estimates, however, become labile in the later years of life. Many older BRCA1/2 mutation carriers who have not developed breas ... Full text Link to item Cite

Comparison of survival outcomes for patients with Stage III vs de novo Stage IV breast cancer.

Journal Article Cancer · May 15, 2025 PURPOSE: Improvements in systemic therapy have resulted in significant heterogeneity in survival outcomes for metastatic breast cancer patients. As such, recently proposed staging guidelines for de novo metastatic breast cancer stratify patients into four ... Full text Link to item Cite

Risk Stratification for Sentinel Lymph Node Positivity in Older Women With Early-Stage Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2 Neu-Negative Invasive Breast Cancer.

Journal Article JCO Clin Cancer Inform · March 2025 PURPOSE: Guidelines recommend omission of sentinel lymph node biopsy (SLNB) for axillary staging in select patients age 70 years and older with early-stage estrogen receptor-positive (ER+), human epidermal growth factor receptor 2 neu-negative (HER2-) inva ... Full text Link to item Cite

Trends in Axillary Lymph Node Dissection After Mastectomy Among Patients With Limited Nodal Burden.

Journal Article JAMA Netw Open · February 3, 2025 IMPORTANCE: Current practices in axillary treatment for patients with breast cancer who receive a mastectomy for node-positive disease are unknown. For patients who receive postmastectomy radiotherapy (PMRT), the addition of axillary lymph node dissection ... Full text Link to item Cite

Germline genetic mutations in a multi-center cohort of 248 phyllodes tumors.

Journal Article Breast Cancer Res Treat · January 2025 PURPOSE: Germline genetic mutations in women with phyllodes tumors (PT) are understudied, although some describe associations of PT with various mutations. We sought to determine the prevalence of pathogenic/likely pathogenic (P/LP) variants in women with ... Full text Link to item Cite

Genomic landscape of malignant phyllodes tumors reveals multiple targetable opportunities.

Conference Oncologist · December 6, 2024 BACKGROUND: Malignant phyllodes tumors (MPT) are rare fibroepithelial breast cancers with no known effective systemic therapy; metastatic progression portends a dismal prognosis. We sought to describe the genomic landscape of MPTs through genomic profiling ... Full text Link to item Cite

Omission of Axillary Lymph Node Dissection in Patients with Residual Nodal Disease After Neoadjuvant Chemotherapy.

Conference Ann Surg Oncol · December 2024 BACKGROUND: Axillary management after neoadjuvant chemotherapy (NAC) is evolving but axillary lymph node dissection (ALND) remains the standard of care for patients with residual nodal disease. The results of the Alliance A011202 trial evaluating the oncol ... Full text Link to item Cite

Triple-Negative Breast Cancer in Older Patients: Does SLNB Guide Therapy?

Journal Article Ann Surg Oncol · December 2024 BACKGROUND: Older breast cancer patients represent a heterogeneous population. Studies demonstrate that sentinel lymph node biopsy (SLNB) omission may be appropriate in some clinical scenarios, yet patients with triple-negative breast cancer (TNBC) are oft ... Full text Link to item Cite

Genomic Landscape of Malignant Phyllodes Tumors Identifies Subsets for Targeted Therapy.

Journal Article JCO Precis Oncol · December 2024 PURPOSE: Malignant phyllodes tumors (MPTs) are rare fibroepithelial tumors of the breast with aggressive biologic behavior and high recurrence rates. Surgery remains the primary treatment modality for these tumors; however, initial investigations suggest a ... Full text Link to item Cite

Rates of Pathologic Complete Response and Overall Survival in Patients with Inflammatory Breast Cancer: A National Cancer Database Study.

Conference Ann Surg Oncol · November 2024 BACKGROUND: Patients with inflammatory breast cancer (IBC) have worse survival compared with stage III non-IBC matched cohorts; however, the prognostic significance of achieving pathologic complete response (pCR) in the setting of IBC is not well described ... Full text Link to item Cite

Utility of Axillary Staging in Older Patients with HER2-Positive Breast Cancer.

Journal Article Ann Surg Oncol · October 2024 BACKGROUND: The utility of sentinel lymph node biopsy (SLNB) in older patients remains controversial. Advancements in human epidermal growth factor receptor 2 (HER2)-directed therapy have revolutionized disease response rates and prognosis, supporting effo ... Full text Link to item Cite

Breast conservation surgery

Chapter · September 24, 2024 Due to tremendous advancements in breast cancer screening techniques, we now have the ability to detect breast cancer at earlier stages of disease. Often times, the cancer can be identified before the patient is able to palpate a mass. Localization of thes ... Full text Cite

Management of patients with liver-confined, synchronous metastatic breast cancer

Journal Article Surgical Oncology Insight · September 1, 2024 Introduction: Approximately 5 % of patients with new breast cancer diagnoses have stage IV disease and 10 % of these patients have liver-confined metastases. The surgical management of synchronous liver metastases remains controversial. Methods: The Nation ... Full text Cite

Relapsing malignant phyllodes tumour presenting as isolated acrometastases.

Journal Article BMJ Case Rep · July 3, 2024 Malignant phyllodes tumours (PTs) are aggressive neoplasms with high rates of local recurrence and distant metastasis. With no known effective chemotherapy and no approved targeted therapy in the setting of metastatic disease, prognosis is limited with an ... Full text Link to item Cite

Axillary nodal disease burden is not associated with an elevated 21-gene recurrence score in post-menopausal women presenting with a clinically negative axilla.

Journal Article Am J Surg · July 2024 BACKGROUND: The predictive and prognostic value of the recurrence score (RS) has emphasized the importance of tumor biology and has reduced the prognostic implications of limited nodal burden in post-menopausal women with HR+/HER2-invasive breast cancer (I ... Full text Link to item Cite

Breast Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · July 2024 Breast cancer is treated with a multidisciplinary approach involving surgical oncology, radiation oncology, and medical oncology. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Breast Cancer include recommendations for clinical man ... Full text Link to item Cite

Omission of Axillary Dissection Following Nodal Downstaging With Neoadjuvant Chemotherapy.

Journal Article JAMA Oncol · June 1, 2024 IMPORTANCE: Data on oncological outcomes after omission of axillary lymph node dissection (ALND) in patients with breast cancer that downstages from node positive to negative with neoadjuvant chemotherapy are sparse. Additionally, the best axillary surgica ... Full text Link to item Cite

Racial/Ethnic Disparities in Pathologic Complete Response and Overall Survival in Patients With Triple-Negative Breast Cancer Treated With Neoadjuvant Chemotherapy.

Journal Article J Clin Oncol · May 10, 2024 PURPOSE: Black women have higher rates of death from triple-negative breast cancer (TNBC) than White women. We hypothesized that pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) and overall survival (OS) may vary by race/ethnicity in pa ... Full text Link to item Cite

Anatomy Versus Biology: What Guides Chemotherapy Decisions in Older Patients With Breast Cancer?

Journal Article J Surg Res · April 2024 INTRODUCTION: With the increasing utilization of genomic assays, such as the Oncotype DX recurrence score (RS), the relevance of anatomic staging has been questioned for select older patients with breast cancer. We sought to evaluate differences in chemoth ... Full text Link to item Cite

Neoadjuvant Chemotherapy and Endocrine Therapy for Older Patients with Estrogen Receptor Positive Breast Cancer: Comparison of Approaches.

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Benefits of a pathologic complete response (pCR) following neoadjuvant therapy are well established, yet outcomes for older women are understudied. We sought to examine the pCR and overall survival (OS) rates of women with estrogen receptor (ER ... Full text Link to item Cite

NCCN Guidelines® Insights: Breast Cancer, Version 4.2023.

Journal Article J Natl Compr Canc Netw · June 2023 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Breast Cancer address all aspects of management for breast cancer. The treatment landscape of metastatic breast cancer is evolving constantly. The therapeutic strategy takes into consi ... Full text Link to item Cite

Survival Benefit of Chemotherapy According to 21-Gene Recurrence Score in Young Women with Breast Cancer.

Journal Article Ann Surg Oncol · April 2023 BACKGROUND: Initial trials evaluating Oncotype DX, reported as a recurrence score (RS) from 0 to 100, were not powered to evaluate overall survival, and premenopausal women were underrepresented. The purpose of this study was to explore the benefit of chem ... Full text Link to item Cite

Racial-ethnic variations in phyllodes tumors among a multicenter United States cohort.

Journal Article J Surg Oncol · March 2023 BACKGROUND AND OBJECTIVES: Previous studies have identified racial-ethnic differences in the diagnostic patterns and recurrence outcomes of women with phyllodes tumors (PT). However, these studies are generally limited in size and generalizability. We ther ... Full text Link to item Cite

Abstract P3-05-20: Low 21-Gene Recurrence Score Is Not Associated with a High Axillary Nodal Burden in Post-Menopausal Women Presenting with a Clinically Negative Axilla

Conference Cancer Research · March 1, 2023 AbstractBackground: The predictive and prognostic value of the 21-gene recurrence score (RS) has emphasized the importance of tumor biology and minimized the credence of a limited (1-3 positive) nodal burden ... Full text Cite

Abstract P1-06-02: The effect of race on pathologic complete response rates and overall survival in patients with triple negative breast cancer

Conference Cancer Research · March 1, 2023 AbstractIntroduction: Despite the recent overall improvement in survival for patients with breast cancer, racial disparities in outcomes persist. While studies have demonstrated that socioeconomic factors an ... Full text Cite

The role of tumor phenotype in the surgical treatment of early-stage breast cancer.

Conference Am J Surg · January 2023 BACKGROUND: We investigated whether tumor phenotype influences surgical decision-making, and how that may impact overall survival (OS) for early-stage breast cancer. METHODS: Women aged 18-69 with cT0-2/cN0/cM0 breast cancer in the National Cancer Database ... Full text Link to item Cite

Changing Demographics in Young Women with Breast Cancer Suggest Improved Access to Screening

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · 2023 Cite

ShouldStage IA Breast Cancerbe Expanded?

Conference ANNALS OF SURGICAL ONCOLOGY · 2023 Cite

Inflammatory Breast Cancer

Chapter · January 1, 2023 Inflammatory breast cancer (IBC) is a rare presentation of locally advanced breast cancer. Although the incidence is 1% to 3%, IBC has a disproportionally dismal prognosis with a 5-year survival rate of 41% overall in the United States. IBC is a clinical d ... Full text Cite

The Influence of Body Mass Index on the Histopathology and Outcomes of Patients Diagnosed with Atypical Breast Lesions.

Conference Ann Surg Oncol · October 2022 BACKGROUND: Multiple studies have demonstrated a link between obesity and breast cancer; however, the potential association between obesity and atypical high-risk breast lesions has not been well characterized. We sought to evaluate the characteristics and ... Full text Link to item Cite

Margin Management and Adjuvant Therapy for Phyllodes Tumors: Practice Patterns of the American Society of Breast Surgeons Members.

Conference Ann Surg Oncol · October 2022 BACKGROUND: Phyllodes tumors (PTs) are rare breast neoplasms with variable clinical behavior by histologic type: benign, borderline, or malignant. Until recently, management guidelines recommended one approach for all subtypes. METHODS: A 21-question surve ... Full text Link to item Cite

Surgical Treatment of de novo Metastatic Breast Cancer

Journal Article Current Breast Cancer Reports · September 1, 2022 Purpose of review: De novo metastatic breast cancer (dnMBC) accounts for approximately 6% of all new breast cancers each year. While the survival benefits from removing the primary tumor in patients with MBC remain unclear, many patients still undergo surg ... Full text Cite

Breast Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · June 2022 The therapeutic options for patients with noninvasive or invasive breast cancer are complex and varied. These NCCN Clinical Practice Guidelines for Breast Cancer include recommendations for clinical management of patients with carcinoma in situ, invasive b ... Full text Link to item Cite

Disparities at the Intersection of Race and Ethnicity: Examining Trends and Outcomes in Hispanic Women With Breast Cancer.

Journal Article JCO Oncol Pract · May 2022 PURPOSE: We sought to examine tumor subtype, stage at diagnosis, time to surgery (TTS), and overall survival (OS) among Hispanic patients of different races and among Hispanic and non-Hispanic (NH) women of the same race. METHODS: Women 18 years of age or ... Full text Link to item Cite

Malignant phyllodes tumor and primary breast sarcoma; distinct rare tumors of the breast.

Conference J Surg Oncol · May 2022 BACKGROUND: Malignant phyllodes (MP) and primary breast sarcomas (PBS) are rare neoplasms with overlapping histopathologic features. We compared overall survival (OS) and estimated the association of surgery and therapies with OS. METHODS: We utilized the ... Full text Link to item Cite

Does Angiosarcoma of the Breast Need Nodal Staging?

Journal Article J Am Coll Surg · May 1, 2022 BACKGROUND: Breast angiosarcoma is a rare malignancy classically associated with hematogenous metastases. We sought to determine the prevalence of pathologic nodal involvement in patients with nonmetastatic, resected breast angiosarcoma and its association ... Full text Link to item Cite

A Novel Staging System for De Novo Metastatic Breast Cancer Refines Prognostic Estimates.

Journal Article Ann Surg · April 1, 2022 OBJECTIVE: We aim to identify prognostic groups within a de novo metastatic cohort, incorporating both anatomic and biologic factors. BACKGROUND: Staging for breast cancer now includes anatomic and biologic factors, although the guidelines for stage IV dis ... Full text Link to item Cite

Measuring intraoperative surgical instrument use with radio-frequency identification.

Journal Article JAMIA Open · April 2022 OBJECTIVE: Surgical instrument oversupply drives cost, confusion, and workload in the operating room. With an estimated 78%-87% of instruments being unused, many health systems have recognized the need for supply refinement. By manually recording instrumen ... Full text Link to item Cite

Disease characteristics and mortality among Asian women with breast cancer.

Conference Cancer · March 1, 2022 BACKGROUND: Asian women with breast cancer are often studied in aggregate, belying significant intragroup diversity. The authors sought to examine differences in breast cancer characteristics and outcomes among Asian women. METHODS: Asian, non-Hispanic Bla ... Full text Link to item Cite

Utilization of neoadjuvant chemotherapy in high-risk, node-negative early breast cancer.

Journal Article Cancer Med · February 2022 BACKGROUND: Controversy exists regarding the optimal sequence of chemotherapy among women with operable node-negative breast cancers with high-risk tumor biology. We evaluated national patterns of neoadjuvant chemotherapy (NACT) use among women with early- ... Full text Link to item Cite

Case Report: Primary Alveolar Soft Part Sarcoma of the Breast

Conference AMERICAN JOURNAL OF CLINICAL PATHOLOGY · 2022 Cite

Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.

Journal Article Br J Surg · December 1, 2021 BACKGROUND: This study aimed to determine the impact of pulmonary complications on death after surgery both before and during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. METHODS: This was a patient-level, comparative analysis ... Full text Link to item Cite

Survival Outcomes Among Patients with Metastatic Breast Cancer: Review of 47,000 Patients.

Conference Annals of surgical oncology · November 2021 BackgroundAlthough metastatic breast cancer (MBC) remains incurable, advances in therapies have improved survival. Using a contemporary dataset of de novo MBC patients, we explore how overall (OS) and cancer-specific survival (CSS) changed over ti ... Full text Cite

Limited Reporting of Histopathologic Details in a Multi-Institutional Academic Cohort of Phyllodes Tumors: Time for Standardization.

Journal Article Ann Surg Oncol · November 2021 BACKGROUND: Phyllodes tumors are rare fibroepithelial neoplasms that are classified by tiered histopathologic features. While there are protocols for the reporting of cancer specimens, no standardized reporting protocol exists for phyllodes. METHODS: We pe ... Full text Link to item Cite

Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.

Journal Article Lancet Oncol · November 2021 BACKGROUND: Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during ... Full text Link to item Cite

Mortality in Older Patients with Breast Cancer Undergoing Breast Surgery: How Low is "Low Risk"?

Conference Ann Surg Oncol · October 2021 BACKGROUND: Breast surgery carries a low risk of postoperative mortality. For older patients with multiple comorbidities, even low-risk procedures can confer some increased perioperative risk. We sought to identify factors associated with postoperative mor ... Full text Link to item Cite

Contralateral Axillary Nodal Metastases: Stage IV Disease or a Manifestation of Progressive Locally Advanced Breast Cancer?

Conference Annals of surgical oncology · October 2021 BackgroundContralateral axillary nodal metastases (CAM) is classified as stage IV disease, although many centers treat CAM with curative intent. We hypothesized that patients with CAM, treated with multimodality therapy, would have improved overal ... Full text Cite

Radiofrequency Identification Track for Tray Optimization: An Instrument Utilization Pilot Study in Surgical Oncology.

Journal Article J Surg Res · August 2021 BACKGROUND: Surgical instrument tray reduction attempts to minimize intraoperative inefficiency and processing costs. Previous reduction methods relied on trained observers manually recording instrument use (i.e. human ethnography), and surgeon and/or staf ... Full text Link to item Cite

Characterizing participants in the North Carolina Breast and Cervical Cancer Control Program: A retrospective review of 90,000 women.

Conference Cancer · July 15, 2021 BACKGROUND: The North Carolina Breast and Cervical Cancer Control Program (NC BCCCP) provides breast cancer screening services to underserved women to mitigate disparities in access to care. The authors sought to characterize this understudied population. ... Full text Link to item Cite

The Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In Situ in Patients with Intraductal Papilloma without Atypia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 034).

Journal Article Annals of surgical oncology · May 2021 BackgroundAvailable retrospective data suggest the upgrade rate for intraductal papilloma (IP) without atypia on core biopsy (CB) ranges from 0 to 12%, leading to variation in recommendations. We conducted a prospective multi-institutional trial ( ... Full text Cite

Treatment Patterns and Outcomes of Women with Breast Cancer and Supraclavicular Nodal Metastases.

Journal Article Ann Surg Oncol · April 2021 BACKGROUND: In 2002, breast cancer patients with supraclavicular nodal metastases (cN3c) were downstaged from AJCC stage IV to IIIc, prompting management with locoregional treatment. We sought to estimate the impact of multimodal therapy on overall surviva ... Full text Link to item Cite

Time to surgery among women treated with neoadjuvant systemic therapy and upfront surgery for breast cancer.

Journal Article Breast Cancer Res Treat · April 2021 PURPOSE: Time to surgery (TTS) is a potentially modifiable factor associated with survival after breast cancer diagnosis and can serve as a proxy for quality of oncologic care coordination. We sought to determine whether factors associated with delays in T ... Full text Link to item Cite

Contemporary Multi-Institutional Cohort of 550 Cases of Phyllodes Tumors (2007-2017) Demonstrates a Need for More Individualized Margin Guidelines.

Journal Article J Clin Oncol · January 20, 2021 PURPOSE: Phyllodes tumors (PTs) are rare breast neoplasms, which have little granular data on margins. Current guidelines recommend ≥ 1 cm margins; however, recent data suggest narrower margins are sufficient, and for benign PT, a negative margin may not b ... Full text Link to item Cite

Surgery for Men with Breast Cancer: Do the Same Data Still Apply?

Journal Article Ann Surg Oncol · November 2020 BACKGROUND: Men represent a small proportion of breast cancer diagnoses, and they are often excluded from clinical trials. Current treatments are largely extrapolated from evidence in women. We compare practice patterns between men and women with breast ca ... Full text Link to item Cite

Germline Genetic Mutations in a Multi-center Contemporary Cohort of 550 Phyllodes Tumors: An Opportunity for Expanded Multi-gene Panel Testing.

Conference Ann Surg Oncol · October 2020 BACKGROUND: A paucity of data exists regarding inherited mutations associated with phyllodes tumors (PT); however, some are reported (TP53, BRCA1, and RB1). A PT diagnosis does not meet NCCN criteria for testing, including within Li-Fraumeni Syndrome (TP53 ... Full text Link to item Cite

Surgical Management of the Axilla in Elderly Women With Node-Positive Breast Cancer.

Journal Article J Surg Res · October 2020 BACKGROUND: Elderly women with clinically node-positive (cN+) breast cancer (BC) often have comorbidities that limit life expectancy and complicate treatment. We sought to determine whether the number of lymph nodes (LNs) retrieved among older women with n ... Full text Link to item Cite

The Evolution of Breast Satisfaction and Well-Being after Breast Cancer: A Propensity-Matched Comparison to the Norm.

Journal Article Plast Reconstr Surg · March 2020 BACKGROUND: Breast cancer survival continues to improve, with women living longer after treatment. It is not well understood how long-term satisfaction and well-being differ following treatment or how types of reconstruction differ when compared to the nor ... Full text Link to item Cite

Abstract P3-08-10: Characterization of oncotype DX recurrence score and chemotherapy utilization patterns in young women (≤40) with early stage ER+/HER-, lymph node negative breast cancer

Conference Cancer Research · February 15, 2020 AbstractBackground: Meta-analyses have demonstrated that young women ≤40 (YW) derive the most benefit from chemotherapy (EBCTCG, Lancet. 1998). Oncotype DX was designed to determine the benefit of chemothera ... Full text Cite

Axillary lymph node dissection in node-positive breast cancer: are ten nodes adequate and when is enough, enough?

Conference Breast Cancer Res Treat · February 2020 PURPOSE: National guidelines define adequate axillary lymph node dissections as those yielding ≥ 10 lymph nodes (LNs). We aimed to identify the optimal LN yield among node-positive patients. METHODS: Using the National Cancer Data Base (2010-2015), we cate ... Full text Link to item Cite

Breast cancer tumor histopathology, stage at presentation, and treatment in the extremes of age.

Conference Breast Cancer Res Treat · February 2020 BACKGROUND: Given presumed differences in disease severity between young (≤ 45 years) and elderly (≥ 75 years) women with breast cancer, we sought to compare tumor histopathology, stage at presentation, patterns of care, and survival at the extremes of age ... Full text Link to item Cite

Nodal Response to Neoadjuvant Chemotherapy Predicts Receipt of Radiation Therapy After Breast Cancer Diagnosis.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2020 BACKGROUND: Pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT) is associated with improved overall survival (OS) in patients with breast cancer, but it is unclear how post-NACT response influences radiation therapy administration in p ... Full text Open Access Link to item Cite

Extent of axillary surgery in inflammatory breast cancer: a survival analysis of 3500 patients.

Journal Article Breast Cancer Res Treat · February 2020 PURPOSE: Inflammatory breast cancer (IBC) is an aggressive variant for which axillary lymph node (LN) dissection following neoadjuvant chemotherapy (NACT) remains standard of care. But with increasingly effective systemic therapy, it is unclear whether mor ... Full text Link to item Cite

Implications for Breast Cancer Restaging Based on the 8th Edition AJCC Staging Manual.

Journal Article Ann Surg · January 2020 OBJECTIVE: We assessed the changes that have resulted from the latest breast cancer staging guidelines and the potential impact on prognosis. BACKGROUND: Contemporary data suggest that combining anatomic staging and tumor biology yields a predictive synerg ... Full text Link to item Cite

Surgery for Men with Breast Cancer: Do the Same Data Still Apply?

Conference ANNALS OF SURGICAL ONCOLOGY · 2020 Cite

Does Breast Density Increase the Risk of Re-excision for Women with Breast Cancer Having Breast-Conservation Therapy?

Journal Article Ann Surg Oncol · December 2019 BACKGROUND: Women with dense breasts may have less-accurate preoperative evaluation of extent of disease, potentially affecting the achievement of negative margins. The goal of this study is to examine the association between breast density and re-excision ... Full text Link to item Cite

Was Reexcision Less Frequent for Patients with Lobular Breast Cancer After Publication of the SSO-ASTRO Margin Guidelines?

Journal Article Ann Surg Oncol · November 2019 BACKGROUND: The Society of Surgical Oncology and American Society for Radiation Oncology consensus guidelines defined a negative margin for breast-conserving surgery (BCS) as no ink on tumor, and implementation has reduced rates of additional surgery for p ... Full text Link to item Cite

Decreasing rates of axillary lymph node dissections over time: Implications for surgical resident exposure and operative skills development.

Conference Am J Surg · October 2019 BACKGROUND: Sentinel lymph node biopsy has supplanted axillary lymph node dissection (ALND) in clinically node-negative breast cancer and select node-positive disease. We hypothesized a decreasing rate of both ALND and resident exposure over time. METHODS: ... Full text Link to item Cite

DCIS with Microinvasion: Is It In Situ or Invasive Disease?

Conference Ann Surg Oncol · October 2019 BACKGROUND: Ductal carcinoma in situ (DCIS) with microinvasion (DCISM) can be challenging in balancing the risks of overtreatment versus undertreatment. We compared DCISM, pure DCIS, and small volume (T1a) invasive ductal carcinoma (IDC) as related to hist ... Full text Link to item Cite

Neoadjuvant Endocrine Therapy Versus Neoadjuvant Chemotherapy in Node-Positive Invasive Lobular Carcinoma.

Conference Ann Surg Oncol · October 2019 BACKGROUND: Neoadjuvant chemotherapy (NACT) is often recommended for patients with node-positive invasive lobular carcinoma (ILC) despite unclear benefit in this largely hormone receptor-positive (HR+) group. We sought to compare overall survival (OS) betw ... Full text Link to item Cite

Clinical and pathological stage discordance among 433,514 breast cancer patients.

Journal Article Am J Surg · October 2019 BACKGROUND: We aim to determine clinical and pathological stage discordance rates and to evaluate factors associated with discordance. METHODS: Adults with clinical stages I-III breast cancer were identified from the National Cancer Data Base. Concordance ... Full text Open Access Link to item Cite

Ductal Carcinoma In Situ Management: All or Nothing, or Something in between?

Journal Article Current Breast Cancer Reports · September 15, 2019 Purpose of Review: Standard treatment for ductal carcinoma in situ (DCIS) is similar to that of invasive carcinoma. However, there is significant controversy regarding the true clinical implications of DCIS, and thus, the best management strategy. The aim ... Full text Cite

The Influence of Age on the Histopathology and Prognosis of Atypical Breast Lesions.

Journal Article J Surg Res · September 2019 BACKGROUND: Although several prognostic variables and risk factors for breast cancer are age-related, the association between age and risk of cancer with breast atypia is controversial. This study aimed to compare the type of breast atypia and risk of unde ... Full text Open Access Link to item Cite

The impact of chemotherapy sequence on survival in node-positive invasive lobular carcinoma.

Journal Article J Surg Oncol · August 2019 BACKGROUND AND OBJECTIVES: We sought to evaluate the impact of chemotherapy sequence on survival by comparing node-positive invasive lobular carcinoma (ILC) patients who received neoadjuvant (NACT) and adjuvant (ACT) chemotherapy. METHODS: cT1-4c, cN1-3 IL ... Full text Open Access Link to item Cite

Intraoperative Versus Extended Antibiotic Prophylaxis in Liver Transplant Surgery: A Randomized Controlled Pilot Trial.

Journal Article Liver Transpl · July 2019 The appropriate duration of surgical antibiotic prophylaxis in orthotopic liver transplantation (OLT) in the presence of significant iatrogenic immunosuppression is unclear. We hypothesized that 72 hours of perioperative antibiotic prophylaxis would decrea ... Full text Link to item Cite

Surgical Resection of the Primary Tumor in Women With De Novo Stage IV Breast Cancer: Contemporary Practice Patterns and Survival Analysis.

Journal Article Ann Surg · March 2019 OBJECTIVE: We evaluated patterns of surgical care and their association with overall survival among a contemporary cohort of women with stage IV breast cancer. BACKGROUND: Surgical resection of the primary tumor remains controversial among women with stage ... Full text Link to item Cite

Axillary Nodal Evaluation in Elderly Breast Cancer Patients: Potential Effects on Treatment Decisions and Survival.

Conference Ann Surg Oncol · October 2018 BACKGROUND: Recent studies suggest that surgical lymph node (LN) evaluation may be omitted in select elderly breast cancer patients as it may not influence adjuvant therapy decisions. To evaluate differences in adjuvant therapy receipt and overall survival ... Full text Link to item Cite

The Association of Extent of Axillary Surgery and Survival in Women with N2-3 Invasive Breast Cancer.

Journal Article Ann Surg Oncol · October 2018 BACKGROUND: Although surgical management of the axilla for breast cancer continues to evolve, axillary lymphadenectomy remains the standard of care for women with advanced nodal disease. We sought to evaluate national patterns of care in axillary surgery, ... Full text Link to item Cite

The Clinical Significance of Breast-only and Node-only Pathologic Complete Response (pCR) After Neoadjuvant Chemotherapy (NACT): A Review of 20,000 Breast Cancer Patients in the National Cancer Data Base (NCDB).

Journal Article Ann Surg · October 2018 OBJECTIVE: To determine whether the association between overall survival (OS) and response to neoadjuvant chemotherapy (NACT) in breast cancer patients varies with tumor subtype and anatomic extent of pathologic complete response (pCR). BACKGROUND: pCR aft ... Full text Link to item Cite

Metaplastic Breast Cancer Treatment and Outcomes in 2500 Patients: A Retrospective Analysis of a National Oncology Database.

Journal Article Ann Surg Oncol · August 2018 BACKGROUND: Metaplastic breast cancer (MBC) is characterized by chemoresistance and hematogenous spread. We sought to identify factors associated with improved MBC outcomes and increased likelihood of MBC diagnosis. METHODS: Women ≥ 18 years of age with st ... Full text Link to item Cite

Pediatric phyllodes tumors: A review of the National Cancer Data Base and adherence to NCCN guidelines for phyllodes tumor treatment.

Journal Article J Pediatr Surg · June 2018 BACKGROUND: Phyllodes tumors are fibroepithelial breast lesions that are uncommon in women and rare among children. Due to scarcity, few large pediatric phyllodes tumor series exist. Current guidelines do not differentiate treatment recommendations between ... Full text Link to item Cite

Extent of axillary surgery in women with Stage IV breast cancer

Conference ANNALS OF SURGICAL ONCOLOGY · June 1, 2018 Link to item Cite

Restaging de novo metastatic breast cancer to refine prognostic estimates.

Conference Journal of Clinical Oncology · May 20, 2018 Full text Cite

Patient Age and Tumor Subtype Predict the Extent of Axillary Surgery Among Breast Cancer Patients Eligible for the American College of Surgeons Oncology Group Trial Z0011.

Journal Article Ann Surg Oncol · November 2017 BACKGROUND: The American College of Surgeons Oncology Group (ACOSOG) Z0011 trial established the safety of omitting axillary lymph node dissection (ALND) for early-stage breast cancer patients with limited nodal disease undergoing lumpectomy. We examined t ... Full text Link to item Cite

A population-based analysis of treatment and outcomes in 2,500 metaplastic breast cancer patients.

Conference Journal of Clinical Oncology · May 20, 2017 532 Background: Metaplastic breast cancer (MBC) is a rare, aggressive variant that is often triple negative (TN). Current guidelines recommend use of standard receptor-based treatment for MBC despite evidence of chemoresistance. ... Full text Cite

The epidemiology of metaplastic breast cancer: A review of 2,500 cases from the national cancer database.

Conference Journal of Clinical Oncology · May 20, 2017 1570 Background: Metaplastic breast cancer (MBC) is a rare, aggressive, sarcomatoid breast cancer that was first described in 1973 but only became recognized as a histologically distinct entity in 2000. Given the paucity of data ... Full text Cite

Temporal associations between prognostic indicators and overall survival after breast cancer.

Conference Journal of Clinical Oncology · May 20, 2017 e18144 Background: Breast oncologists have little guidance on predicting long term outcomes after interval survival. We aim to evaluate the association of overall survival (OS) with select factors at multiple time points. Methods ... Full text Cite

Impact of self-reported data on the acquisition of multi-generational family history and lifestyle factors among women seen in a high-risk breast screening program: a focus on modifiable risk factors and genetic referral.

Journal Article Breast Cancer Res Treat · April 2017 BACKGROUND: The phrase "high-risk for breast cancer" is used to identify various groups at elevated cancer risk, and the appropriate surveillance and risk-reducing strategies differ based on the etiology of risk. Here, we review the utility of patient-repo ... Full text Link to item Cite

Early Adoption of the SSO-ASTRO Consensus Guidelines on Margins for Breast-Conserving Surgery with Whole-Breast Irradiation in Stage I and II Invasive Breast Cancer: Initial Experience from Memorial Sloan Kettering Cancer Center.

Journal Article Ann Surg Oncol · October 2016 BACKGROUND: Reexcision rates in patients undergoing breast-conserving surgery (BCS) for early-stage invasive breast cancer are highly variable. The Society of Surgical Oncology (SSO) and American Society for Radiation Oncology (ASTRO) published consensus g ... Full text Link to item Cite

Excision of an intrapericardial immature teratoma in a 26-week premature neonate.

Journal Article J Pediatr Surg Case Rep · July 2016 We present a case of a 26 week premature newborn with an immature intrapericardial teratoma. The patient was transferred from an outside hospital for management of a large mediastinal mass causing respiratory insufficiency. The newborn was supported with t ... Full text Link to item Cite

De-Escalation of Antibiotics Does Not Increase Mortality in Critically Ill Surgical Patients.

Journal Article Surg Infect (Larchmt) · February 2016 BACKGROUND: Overuse of broad-spectrum antibiotics results in microbial resistance and financially is a healthcare burden. Antibiotic de-escalation refers to starting treatment of a presumed infection with broad-spectrum antibiotics and narrowing drug spect ... Full text Link to item Cite

Reducing Accidental Dislodgement of the Percutaneous Endoscopic Gastrostomy: A Prospective Trial of the "SafetyBreak" Device.

Journal Article Surg Innov · February 2016 BACKGROUND: The percutaneous endoscopic gastrostomy (PEG) is a ubiquitous feeding tube with high rates of accidental dislodgement, with significant morbidity and health care costs. We hypothesized use of a decoupling device is a safe and effective mechanis ... Full text Link to item Cite

Temporal Trends in Blood Stream Infection Isolates from Surgical Patients.

Journal Article Surg Infect (Larchmt) · August 2015 BACKGROUND: Blood stream infections (BSIs) are a common source of morbidity and death in hospitalized patients. We hypothesized that the proportions of bacteremia from gram-positive and fungal pathogens have decreased over time, whereas rates of gram-negat ... Full text Link to item Cite

Hypocaloric compared with eucaloric nutritional support and its effect on infection rates in a surgical intensive care unit: a randomized controlled trial.

Journal Article Am J Clin Nutr · November 2014 BACKGROUND: Proper caloric intake goals in critically ill surgical patients are unclear. It is possible that overnutrition can lead to hyperglycemia and an increased risk of infection. OBJECTIVE: This study was conducted to determine whether surgical infec ... Full text Link to item Cite

Influence of bronchoscopy on the diagnosis of and outcomes from ventilator-associated pneumonia.

Journal Article Surg Infect (Larchmt) · October 2014 BACKGROUND: Ventilator-associated pneumonia (VAP) is a common healthcare-associated infection affecting as many as 27% of mechanically ventilated patients. Ventilator-associated pneumonia is an important source of morbidity and mortality in the surgical in ... Full text Link to item Cite

Association of excessive duration of antibiotic therapy for intra-abdominal infection with subsequent extra-abdominal infection and death: a study of 2,552 consecutive infections.

Journal Article Surg Infect (Larchmt) · August 2014 BACKGROUND: We hypothesized that a longer duration of antibiotic treatment for intra-abdominal infections (IAI) would be associated with an increased risk of extra-abdominal infections (EAI) and high mortality. METHODS: We reviewed all IAI occurring in a s ... Full text Link to item Cite

Aspergillus infections in transplant and non-transplant surgical patients.

Journal Article Surg Infect (Larchmt) · June 2014 BACKGROUND: Aspergillus infections are associated commonly with immunocompromised states, such as transplantation and hematologic malignant disease. Although Aspergillus infections among patients having surgery occur primarily in transplant recipients, the ... Full text Link to item Cite

Endoluminal negative-pressure therapy for preventing rectal anastomotic leaks: a pilot study in a pig model.

Journal Article Surg Infect (Larchmt) · April 2014 BACKGROUND: Anastomotic leak after rectal resection carries substantial morbidity and mortality. A diverting ileostomy is beneficial for high-risk anastomoses, but its creation and reversal carry a surgical risk in addition to that of resection itself. We ... Full text Link to item Cite

Donor risk index predicts graft failure reliably but not post-transplant infections.

Journal Article Surg Infect (Larchmt) · April 2014 BACKGROUND: The Donor Risk Index (DRI) is used to predict graft survival following liver transplantation, but has not been used to predict post-operative infections in graft recipients. We hypothesized that lower-quality grafts would result in more frequen ... Full text Link to item Cite

Delayed endoluminal vacuum therapy for rectal anastomotic leaks after rectal resection in a swine model: a new treatment option.

Journal Article Clin Transl Sci · April 2014 Anastomotic leaks are a dreaded surgical complication following colorectal operations. Creation of a temporary proximal diverting ileostomy is used in high-risk anastomoses, however, additional surgical risk is accumulated with its creation and reversal. E ... Full text Link to item Cite

Improvements in pulmonary and general critical care reduces mortality following ventilator-associated pneumonia.

Journal Article J Trauma Acute Care Surg · February 2013 BACKGROUND: Ventilator-associated pneumonia (VAP) is the most common hospital-acquired infection in the intensive care unit, with substantial subsequent mortality. The mortality following VAP declined in the 1980s and 1990s. Experts suggest that little pro ... Full text Link to item Cite

Use of silver in the prevention and treatment of infections: silver review.

Journal Article Surg Infect (Larchmt) · February 2013 BACKGROUND: The use of silver for the treatment of various maladies or to prevent the transmission of infection dates back to at least 4000 b.c.e. Medical applications are documented in the literature throughout the 17th and 18th centuries. The bactericida ... Full text Link to item Cite

Duodenal diverticulum perforation following jejunal feeding tube advancement

Journal Article Journal of Surgical Radiology · January 1, 2013 Overview: An 85 year-old woman underwent a laparoscopic paraesophageal hernia repair complicated by a delayed esophageal leak. Prior to initiation of tube feeds, a jejunal feeding tube was placed through the existing PEG tube fluoroscopically. Following th ... Cite

Options for closure of the infected abdomen.

Journal Article Surg Infect (Larchmt) · December 2012 BACKGROUND: The infected abdomen poses substantial challenges to surgeons, and often, both temporary and definitive closure techniques are required. We reviewed the options available to close the abdominal wall defect encountered frequently during and afte ... Full text Link to item Cite

Gastropexy using the Carter-Thomason device in lieu of T-fasteners in a critically ill, severely obese patient: an innovative technique.

Journal Article Surg Laparosc Endosc Percutan Tech · October 2012 A gastropexy with T-fasteners can maintain gastric apposition to the abdominal wall before a mature gastrocutaneous fistula. In patients at high risk for inadvertently removing their percutaneous endoscopic gastrostomy tube, or those in whom early, uninten ... Full text Link to item Cite

Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: a quasi-experimental, before and after observational cohort study.

Journal Article Lancet Infect Dis · October 2012 BACKGROUND: Antimicrobial treatment in critically ill patients can either be started as soon as infection is suspected or after objective data confirm an infection. We postulated that delaying antimicrobial treatment of patients with suspected infections i ... Full text Link to item Cite

Infections caused by multidrug resistant organisms are not associated with overall, all-cause mortality in the surgical intensive care unit: the 20,000 foot view.

Journal Article J Am Coll Surg · May 2012 BACKGROUND: Resistant pathogens are increasingly common in the ICU, with controversy regarding their relationship to outcomes. We hypothesized that an increasing number of infections with resistant pathogens in our surgical ICU would not be associated with ... Full text Link to item Cite

Management of Infectious Complications in the Critically Ill Obese Patient

Chapter · April 19, 2012 Managing infectious complications in obese critically ill patients presents unique challenges and is associated with significant cost to the health care industry. Generally, obese patients tend to have a higher incidence of blood-stream, catheter-related, ... Full text Cite

Quarantine, isolation, and cohorting: from cholera to Klebsiella.

Journal Article Surg Infect (Larchmt) · April 2012 BACKGROUND: Isolation is defined as the separation of persons with communicable diseases from those who are healthy. This public health practice, along with quarantine, is used to limit the transmission of infectious diseases and provides the foundation of ... Full text Link to item Cite

Severe traumatic head injury affects systemic cytokine expression.

Journal Article J Am Coll Surg · April 2012 BACKGROUND: The neuroimmunologic effect of traumatic head injury remains ill-defined. This study aimed to characterize systemic cytokine profiles among traumatically injured patients to assess the effect of traumatic head injury on the systemic inflammator ... Full text Link to item Cite

Intraductal papillary mucinous neoplasm (IPMN) with extra-pancreatic mucin: a case series and review of the literature.

Journal Article J Gastrointest Surg · April 2012 BACKGROUND: Intraductal papillary mucinous neoplasm (IPMN) is an increasingly recognized pancreatic neoplasm characterized by excessive mucin secretion by ductal epithelial cells resulting in a cystic dilation of the pancreatic duct. AIM: The objective of ... Full text Link to item Cite

Complicated postpartum type B aortic dissection and endovascular repair.

Journal Article Obstet Gynecol · February 2012 BACKGROUND: Fifty percent of aortic dissections in women younger than 40 years occur in association with pregnancy. Of these, half of type B dissections occur in the postpartum period. CASE: A 30-year-old woman was status post spontaneous vaginal delivery ... Full text Link to item Cite

Effective cohorting and "superisolation" in a single intensive care unit in response to an outbreak of diverse multi-drug-resistant organisms.

Journal Article Surg Infect (Larchmt) · October 2011 BACKGROUND: Cohorting patients in dedicated hospital wards or wings during infection outbreaks reduces transmission of organisms, yet frequently, this may not be feasible because of inadequate capacity, especially in the intensive care unit (ICU). We hypot ... Full text Link to item Cite

Late accidental dislodgement of a percutaneous endoscopic gastrostomy tube: an underestimated burden on patients and the health care system.

Journal Article Surg Endosc · October 2011 BACKGROUND: Since its introduction in 1980, the percutaneous endoscopic gastrostomy (PEG) tube has become an efficient means of providing long-term enteral access. Conveniently, the soft inner bumper allows PEG removal with relatively minimal external trac ... Full text Link to item Cite

The novel triad of dorsal agenesis of the pancreas with concurrent pancreatic ductal adenocarcinoma and nonalcoholic chronic calcific pancreatitis: a case series and review of the literature.

Journal Article J Gastrointest Surg · September 2011 INTRODUCTION: Dorsal agenesis of the pancreas (DAP) is a rare congenital anomaly, with only 44 cases having been reported in the English literature since 1966. MATERIALS AND METHODS: A retrospective review of our IRB-approved pancreatic surgery database wa ... Full text Link to item Cite

Differences in morbidity and mortality with percutaneous versus open surgical drainage of postoperative intra-abdominal infections: a review of 686 cases.

Journal Article Am Surg · July 2011 Intra-abdominal infections following surgical procedures result from organ-space surgical site infections, visceral perforations, or anastomotic leaks. We hypothesized that open surgical drainage is associated with increased patient morbidity and mortality ... Link to item Cite

The surgical care improvement project and prevention of post-operative infection, including surgical site infection.

Conference Surg Infect (Larchmt) · June 2011 BACKGROUND: In response to inconsistent compliance with infection prevention measures, the Centers for Medicare & Medicaid Services collaborated with the U.S. Centers for Disease Control and Prevention on the Surgical Infection Prevention (SIP) project, in ... Full text Link to item Cite

Bilateral adrenal hemorrhage: the unrecognized cause of hemodynamic collapse associated with heparin-induced thrombocytopenia.

Journal Article Crit Care Med · April 2011 OBJECTIVE: Heparin-induced thrombocytopenia is a common adverse effect of treatment with heparin resulting in paradoxical thromboses. An immunoglobulin G class "heparin-induced thrombocytopenia antibody" attaches to a heparin-platelet factor 4 protein comp ... Full text Link to item Cite