Ramon Mitra Esclamado

Journal Article Curr Oncol · February 24, 2023 Diffuse reflectance spectroscopy (DRS) is a powerful tool for quantifying optical and physiological tissue properties such as hemoglobin oxygen saturation and vascularity. DRS is increasingly used clinically for distinguishing cancerous lesions from normal ... Full text Link to item Cite

A Retrospective Study of Lymph Node Yield in Lateral Neck Dissection for Papillary Thyroid Carcinoma.

Journal Article Ear Nose Throat J · August 2022 OBJECTIVE: Lateral neck dissection (LND) is important in managing papillary thyroid carcinomas (PTCs). This study aimed to evaluate the relationship between lymph node yield (LNY) for LND and patient outcomes, specifically postoperative serum thyroglobulin ... Full text Link to item Cite

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

Journal Article Ann Clin Transl Neurol · February 2022 OBJECTIVE: Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cereb ... Full text Open Access Link to item Cite

Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.

Journal Article Br J Anaesth · December 2021 BACKGROUND: Cognitive dysfunction after surgery is a major issue in older adults. Here, we determined the effect of APOE4 on perioperative neurocognitive function in older patients. METHODS: We enrolled 140 English-speaking patients ≥60 yr old scheduled fo ... Full text Open Access Link to item Cite

Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.

Journal Article Sci Rep · February 4, 2021 Arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) derived lipids play key roles in initiating and resolving inflammation. Neuro-inflammation is thought to play a causal role in perioperative neurocognitive disorders, yet th ... Full text Open Access Link to item Cite

A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.

Journal Article J Neurol · July 2020 OBJECTIVE: Lumbar punctures (LPs) are important for obtaining CSF in neurology studies but are associated with adverse events and feared by many patients. We determined adverse event rates and pain scores in patients prospectively enrolled in two cohort st ... Full text Link to item Cite

Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.

Journal Article Anesth Analg · November 2019 Animal models suggest postoperative cognitive dysfunction may be caused by brain monocyte influx. To study this in humans, we developed a flow cytometry panel to profile cerebrospinal fluid (CSF) samples collected before and after major noncardiac surgery ... Full text Open Access Link to item Cite

Assessing effects of pressure on tumor and normal tissue physiology using an automated self-calibrated, pressure-sensing probe for diffuse reflectance spectroscopy.

Journal Article J Biomed Opt · May 2018 Diffuse reflectance spectroscopy (DRS) represents a quantitative, noninvasive, nondestructive means of assessing vascular oxygenation, vascularity, and structural properties. However, it is known that such measurements can be influenced by the effects of p ... Full text Link to item Cite

Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.

Journal Article Front Syst Neurosci · 2017 Each year over 16 million older Americans undergo general anesthesia for surgery, and up to 40% develop postoperative delirium and/or cognitive dysfunction (POCD). Delirium and POCD are each associated with decreased quality of life, early retirement, incr ... Full text Open Access Link to item Cite

Rare cases of large parapharyngeal lipomas.

Journal Article Am J Otolaryngol · 2016 Primary tumors of the parapharyngeal space are extremely rare, and lipomas are among the least common primary parapharyngeal space masses. Parapharyngeal lipomas typically present as a painless neck mass, and some may present with neurologic deficits or va ... Full text Link to item Cite

Use of a Secondary Essay in the Residency Application Process.

Journal Article JAMA Otolaryngol Head Neck Surg · July 2015 Full text Link to item Cite

Lip cancer

Chapter · November 3, 2014 Cite

An exponential growth in incidence of thyroid cancer: trends and impact of CT imaging.

Journal Article AJNR Am J Neuroradiol · April 2014 BACKGROUND AND PURPOSE: Workup of incidental thyroid nodules detected on CT imaging could be contributing to the increased diagnosis of small thyroid cancers. The purpose of this study was to evaluate recent trends in the incidence of thyroid cancer, and t ... Full text Link to item Cite

Impact of Concurrent Chemoradiation on T Cell Populations in Patients With Advanced-Stage Oropharyngeal Squamous Cell Carcinoma

Conference International Journal of Radiation Oncology*Biology*Physics · February 2014 Full text Cite

Journal Club: incidental thyroid nodules detected at imaging: can diagnostic workup be reduced by use of the Society of Radiologists in Ultrasound recommendations and the three-tiered system?

Journal Article AJR Am J Roentgenol · January 2014 OBJECTIVE: The purpose of this study was to determine the number of thyroid nodule workups that could be eliminated and the number of malignant tumors that would be missed if the Society of Radiologists in Ultrasound (SRU) recommendations and the three-tie ... Full text Link to item Cite

Surgical Training and Education in Promoting Professionalism: a comparative assessment of virtue-based leadership development in otolaryngology-head and neck surgery residents.

Journal Article Med Educ Online · October 29, 2013 INTRODUCTION: Surgical Training and Education in Promoting Professionalism (STEPP) was developed in 2011 to train tomorrow's leaders during residency. It is based on virtue ethics and takes an approach similar to West Point military academy. The purpose of ... Full text Link to item Cite

Incidental thyroid nodules on CT: evaluation of 2 risk-categorization methods for work-up of nodules.

Journal Article AJNR Am J Neuroradiol · September 2013 BACKGROUND AND PURPOSE: Thyroid nodules are common incidental findings on CT, but there are no clear guidelines regarding their further diagnostic work-up. This study compares the performance of 2 risk-categorization methods of selecting CT-detected incide ... Full text Link to item Cite

Selecting Among Otolaryngology Residency Applicants to Train as Tomorrow's Leaders.

Journal Article JAMA Otolaryngol Head Neck Surg · August 1, 2013 Full text Link to item Cite

Surgical Training and Education in Promoting Professionalism: a comparative assessment of virtue-based leadership development in otolaryngology-head and neck surgery residents.

Journal Article Med Educ Online · January 2013 Introduction Surgical Training and Education in Promoting Professionalism (STEPP) was developed in 2011 to train tomorrow's leaders during residency. It is based on virtue ethics and takes an approach similar to West Point military academy. The purpose of ... Full text Link to item Cite

Utility of Intraoperative Frozen Sections during Thyroid Surgery.

Journal Article Int J Otolaryngol · 2013 Objective. To describe the usefulness of intraoperative frozen section in the diagnosis and treatment of thyroid nodules where fine needle aspirate biopsies have evidence of follicular neoplasm. Study Design. Retrospective case series. Methods. All patient ... Full text Open Access Link to item Cite

A Clinical Study to Assess Diffuse Reflectance Spectroscopy with an Auto-Calibrated, Pressure-Sensing Optical Probe in Head and Neck Cancer.

A Retrospective Study of Lymph Node Yield in Lateral Neck Dissection for Papillary Thyroid Carcinoma.

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.

Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.

A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.

Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.

Assessing effects of pressure on tumor and normal tissue physiology using an automated self-calibrated, pressure-sensing probe for diffuse reflectance spectroscopy.

Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.

Rare cases of large parapharyngeal lipomas.

Use of a Secondary Essay in the Residency Application Process.

Journal Article JAMA Otolaryngol Head Neck Surg · July 2015 Full text Link to item Cite

Lip cancer

Chapter · November 3, 2014 Cite

An exponential growth in incidence of thyroid cancer: trends and impact of CT imaging.

Impact of Concurrent Chemoradiation on T Cell Populations in Patients With Advanced-Stage Oropharyngeal Squamous Cell Carcinoma

Conference International Journal of Radiation Oncology*Biology*Physics · February 2014 Full text Cite

Journal Club: incidental thyroid nodules detected at imaging: can diagnostic workup be reduced by use of the Society of Radiologists in Ultrasound recommendations and the three-tiered system?

Surgical Training and Education in Promoting Professionalism: a comparative assessment of virtue-based leadership development in otolaryngology-head and neck surgery residents.

Incidental thyroid nodules on CT: evaluation of 2 risk-categorization methods for work-up of nodules.

Selecting Among Otolaryngology Residency Applicants to Train as Tomorrow's Leaders.

Journal Article JAMA Otolaryngol Head Neck Surg · August 1, 2013 Full text Link to item Cite

Surgical Training and Education in Promoting Professionalism: a comparative assessment of virtue-based leadership development in otolaryngology-head and neck surgery residents.

Utility of Intraoperative Frozen Sections during Thyroid Surgery.

Channelling Aristotle: virtue-based professionalism training during residency.

Other Med Educ · November 2012 Full text Link to item Cite

Treatment-induced changes in vocal cord mobility and subsequent local recurrence after organ preservation therapy for laryngeal carcinoma.

Journal Article Head Neck · June 2012 BACKGROUND: As multidisciplinary cancer treatment evolves, strategies to identify patients needing early resection/salvage are necessary. Some have suggested that vocal cord function after organ-preservation treatment may be an indicator. METHODS: A retros ... Full text Link to item Cite

Prospective trial of synchronous bevacizumab, erlotinib, and concurrent chemoradiation in locally advanced head and neck cancer.

Journal Article Clin Cancer Res · March 1, 2012 PURPOSE: We assessed the safety and efficacy of synchronous VEGF and epidermal growth factor receptor (EGFR) blockade with concurrent chemoradiation (CRT) in locally advanced head and neck cancer (HNC). EXPERIMENTAL DESIGN: Newly diagnosed patients with st ... Full text Link to item Cite

Intended single-modality management of T1 and T2 tonsillar carcinomas: retrospective comparison of radical tonsillectomy vs radiation from a single institution.

Journal Article Am J Otolaryngol · 2012 BACKGROUND: T1 and T2 tonsillar squamous cell cancer with limited neck disease can be managed with single-modality radiation or surgery. Over 11 years, 17 patients underwent radical tonsillectomies; and 33 patients underwent radiation-based treatments for ... Full text Link to item Cite

Extent of neck dissection required after concurrent chemoradiation for stage IV head and neck squamous cell carcinoma.

Journal Article Head Neck · March 2010 BACKGROUND: The management of initially bulky nodal disease after primary nonsurgical treatment for stage IV head and neck squamous cell carcinoma (HNSCC) continues to be a subject of debate. METHODS: A retrospective chart review of neck management in pati ... Full text Link to item Cite

Impact of preepiglottic space tumor involvement on concurrent chemoradiation therapy.

Journal Article Am J Otolaryngol · 2010 PURPOSE: The aim of the study was to determine the prognostic impact of preepiglottic space (PES) involvement on local failure after concurrent chemoradiation therapy for squamous cell carcinoma. MATERIALS AND METHODS: Retrospective chart review of patient ... Full text Link to item Cite

Does vocal cord fixation preclude nonsurgical management of laryngeal cancer?

Journal Article Laryngoscope · June 2009 OBJECTIVES/HYPOTHESIS: To determine whether vocal cord fixation precludes nonsurgical management of T3/T4 laryngeal carcinoma. STUDY DESIGN: A retrospective chart review. METHODS: Between 1989 and 2005 patient records with T3/T4 squamous cell carcinoma of ... Full text Link to item Cite

Does vocal cord fixation preclude non-surgical management of laryngeal cancer?

Journal Article Laryngoscope · January 1, 2009 Full text Cite

Organ and function preservation: the role of surgery as the optimal primary modality or as salvage after chemoradiation failure.

Journal Article Semin Radiat Oncol · January 2009 The treatment for squamous cell carcinoma (SCC) of the head and neck has advanced considerably with the use of multimodality therapy including radiation, chemotherapy, and surgery. Efforts to achieve greater rates of disease control and survival have been ... Full text Link to item Cite

Clinical predictors of larynx preservation after multiagent concurrent chemoradiotherapy.

Journal Article Head Neck · December 2008 BACKGROUND: Determining which patients benefit from larynx preservation strategies remains problematic. We reviewed our experience using multiagent concurrent chemoradiotherapy to identify clinical predictors for success. METHODS: Cisplatin and fluorouraci ... Full text Link to item Cite

Ansa cervicalis-to-recurrent laryngeal nerve anastomosis for unilateral vocal fold paralysis: experience of a single institution.

Journal Article Ann Otol Rhinol Laryngol · January 2008 OBJECTIVES: One treatment option for unilateral vocal fold paralysis (UVFP) is ansa cervicalis-to-recurrent laryngeal nerve (ansa-RLN) anastomosis to provide reinnervation to the affected vocal fold. The advantages of this treatment approach are that it 1) ... Full text Link to item Cite

Swallowing outcomes after microvascular head and neck reconstruction: a prospective review of 191 cases.

Journal Article Laryngoscope · August 2007 BACKGROUND: The use of microvascular free tissue flaps tailored specifically to the ablative surgical defects has allowed precise anatomic reconstructions to be performed and, in turn, has improved patient outcomes. We report here the postoperative swallow ... Full text Link to item Cite

Clinical predictors of larynx preservation (LP) after multiagent concurrent chemoradiotherapy (MCCRT)

Conference JOURNAL OF CLINICAL ONCOLOGY · June 20, 2007 Link to item Cite

Ability of positron emission tomography to detect residual neck node disease in patients with head and neck squamous cell carcinoma after definitive chemoradiotherapy.

Journal Article Arch Otolaryngol Head Neck Surg · May 2007 OBJECTIVE: To report our experience using the neck examination, computed tomography (CT), and positron emission tomography (PET) to clinically evaluate node-positive patients with head and neck squamous cell cancer for residual neck node disease after defi ... Full text Link to item Cite

Results of ansa to recurrent laryngeal nerve reinnervation.

Journal Article Otolaryngol Head Neck Surg · March 2007 OBJECTIVE: We sought to describe the results of ansa cervicalis to recurrent laryngeal nerve (ansa-RLN) reinnervation for unilateral vocal fold paralysis. STUDY DESIGN: A chart review was performed on patients undergoing ansa-RLN reinnervation for unilater ... Full text Link to item Cite

Risk factors for hypopharyngeal/upper esophageal stricture formation after concurrent chemoradiation.

Journal Article Head Neck · September 2006 BACKGROUND: Concurrent chemoradiation therapy has been demonstrated to be effective as an organ-sparing treatment for select advanced head and neck squamous cell carcinoma (HNSCC). However, this treatment modality is not without side effects. One side effe ... Full text Link to item Cite

Does positron emission tomography (PET) improve our ability to detect residual neck node (NN) disease in patients with squamous cell head and neck cancer (SCHNC) after definitive chemoradiotherapy?

Journal Article J Clin Oncol · June 20, 2006 5526 Background: Management of the neck in patients undergoing non-operative treatment for SCHNC is controversial. This study details our experience using the neck exam, computerized tomography (CT), and PET to clinically evaluate patients for residual NN ... Link to item Cite

Does positron emission tomography (PET) improve our ability to detect residual neck node (NN) disease in patients with squamous cell head and neck cancer (SCHNC) after definitive chemoradiotherapy?

Conference JOURNAL OF CLINICAL ONCOLOGY · June 20, 2006 Link to item Cite

Concurrent chemoradiotherapy for locally advanced, nonmetastatic, squamous carcinoma of the head and neck: consensus, controversy, and conundrum.

Journal Article J Clin Oncol · June 10, 2006 Radiotherapy and concurrent chemotherapy (CRT) is superior to radiotherapy alone for the treatment of locally advanced, nonmetastatic squamous carcinoma of the head and neck (HNC). Three issues affect the use of CRT as primary treatment for advanced HNC. T ... Full text Link to item Cite

Prospective studies of neck dissection specimens support preservation of sublevel IIB for laryngeal squamous carcinoma with clinically negative neck.

Journal Article J Am Coll Surg · June 2006 Full text Link to item Cite

Multiagent concurrent chemoradiotherapy for locoregionally advanced squamous cell head and neck cancer: mature results from a single institution.

Journal Article J Clin Oncol · March 1, 2006 PURPOSE: A retrospective review with long-term follow-up is reported from the Cleveland Clinic Foundation studying radiation and concurrent multiagent chemotherapy in patients with locoregionally advanced squamous cell head and neck cancer. PATIENTS AND ME ... Full text Link to item Cite

Does acid suppressive therapy reduce the risk of laryngeal cancer recurrence?

Journal Article Laryngoscope · October 2005 OBJECTIVE/HYPOTHESIS: Gastroesophageal reflux disease (GERD) is implicated in laryngeal cancer pathogenesis and recurrence posttherapy. There are currently limited data on the effect of acid suppressive therapy in decreasing the recurrence of laryngeal can ... Full text Link to item Cite

Oncologic effectiveness of selective neck dissection in the N0 irradiated neck.

Journal Article Head Neck · May 2005 BACKGROUND: The incidence and patterns of nodal spread in previously irradiated N0 necks are not well defined. Therefore, the safety and efficacy of selective neck dissection (SND) in this patient population is not well established. In a previous report fr ... Full text Link to item Cite

Analysis of recurrence and survival after hypopharyngeal ablative surgery with radial forearm free flap reconstruction.

Journal Article Laryngoscope · March 2005 OBJECTIVES/HYPOTHESIS: To address the controversial acceptable distal resection margin for the surgical management of patients with hypopharyngeal cancer. STUDY DESIGN: Retrospective review of the records of 28 consecutive patients who underwent pharyngoes ... Full text Link to item Cite

Is the second primary malignancy an important competing cause of death in patients (pts) with squamous cell head and neck cancer (SCHNC)?

Journal Article J Clin Oncol · July 15, 2004 5516 Background: The development of a 2nd (or 3rd) primary malignancy (SPM) is a well recognized problem in pts with SCHNC. Although the prognosis of such pts is not well defined, SPM is felt to be an important competing cause of death. METHODS: We retrosp ... Link to item Cite

Is the second primary malignancy an important competing cause of death in patients (pts) with squamous cell head and neck cancer (SCHNC)?

Conference JOURNAL OF CLINICAL ONCOLOGY · July 15, 2004 Link to item Cite

Role for postoperative radiation therapy in adenoid cystic carcinoma of the head and neck.

Journal Article Laryngoscope · July 2004 OBJECTIVE: Clarify the role for postoperative radiation for adenoid cystic carcinoma (ACC) of the head and neck as it relates to tumor site, T-stage, and surgical margin status. STUDY DESIGN: Retrospective cohort study at an academic tertiary care hospital ... Full text Link to item Cite

Pectoralis major myocutaneous flap vs revascularized free tissue transfer: complications, gastrostomy tube dependence, and hospitalization.

Journal Article Arch Otolaryngol Head Neck Surg · February 2004 OBJECTIVE: To evaluate the factors related to surgical complications, rate of gastrostomy tube (G-tube) dependence, and hospitalization in patients undergoing reconstruction with a pectoralis myocutaneous flap vs a soft-tissue revascularized flap. DESIGN: ... Full text Link to item Cite

Who merits a neck dissection after definitive chemoradiotherapy for N2-N3 squamous cell head and neck cancer?

Journal Article Head Neck · October 2003 BACKGROUND: The role of neck dissection (ND) after definitive chemoradiotherapy for squamous cell head and neck cancer is incompletely defined. We retrospectively reviewed 109 patients with N2-N3 disease treated with chemoradiotherapy to identify predictor ... Full text Link to item Cite

Prevalence of nodal metastases in the submuscular recess (level IIb) during selective neck dissection.

Journal Article Arch Otolaryngol Head Neck Surg · July 2003 OBJECTIVES: To determine the prevalence of nodal metastases in the submuscular recess (SMR) in patients undergoing selective neck dissection (SND) and to identify potential risk factors for the presence of metastatic disease in the SMR. DESIGN: Prospective ... Full text Link to item Cite

Reconstruction with radial forearm flaps after ablative surgery for hypopharyngeal cancer.

Journal Article Head Neck · April 2003 BACKGROUND: Patients afflicted with advanced hypopharyngeal cancer must contend with both potentially poor survival prognosis and a compromised quality of remaining life. After extensive ablative surgery, it is imperative to use a reliable, low morbidity r ... Full text Link to item Cite

The effect of radiation therapy on microcystic adnexal carcinoma: a case report.

Journal Article Head Neck · March 2003 BACKGROUND: Microcystic adnexal carcinoma (MAC) is a rare, locally aggressive tumor. Treatment for this neoplasm typically requires extensive local excision leading to morbidity. Therefore, the temptation to use alternative treatment options remains high. ... Full text Link to item Cite

Paranasal sinus malignancies: an 18-year single institution experience.

Journal Article Laryngoscope · November 2002 OBJECTIVES: To characterize a single institution experience with management of paranasal sinus malignancies during an 18-year time period, report long-term survival rates, and identify prognostic factors. STUDY DESIGN: Retrospective chart review. METHODS: ... Full text Link to item Cite

Maximizing local control and organ preservation in stage IV squamous cell head and neck cancer With hyperfractionated radiation and concurrent chemotherapy.

Journal Article J Clin Oncol · March 1, 2002 PURPOSE: Results are reported from an aggressive chemoradiotherapy protocol for advanced squamous cell head and neck cancer. PATIENTS AND METHODS: Patients with advanced squamous cell head and neck cancer were treated with hyperfractionated radiation thera ... Full text Link to item Cite

Recurrence rates after selective neck dissection in the N0 irradiated neck.

Journal Article Arch Otolaryngol Head Neck Surg · March 2002 OBJECTIVES: To define patterns of subclinical metastases in irradiated N0 necks with recurrent or persistent primary site disease and to determine the regional control rate when selective neck dissection (SND) is used in this setting. PATIENTS AND INTERVEN ... Full text Link to item Cite

Selective neck dissection for the treatment of neck metastasis from squamous cell carcinoma of the head and neck.

Journal Article Laryngoscope · March 2002 OBJECTIVE: Our objective was to determine the proportion of patients disease free in the neck, with the primary site controlled, who have been treated with a selective neck dissection (SND) for squamous cell carcinoma (SCCa) of the upper aerodigestive trac ... Full text Link to item Cite

Preoperative magnetic resonance angiography in fibular-free flap reconstruction of head and neck defects.

Journal Article Head Neck · October 2001 BACKGROUND: Conventional angiography has been recommended for imaging of the leg prior to fibular-free flap harvest. Magnetic resonance angiography (MRA) offers a similar level of accuracy at no risk to the patient and at a lower cost. METHODS: Thirty-two ... Full text Link to item Cite

Selective cricothyroid muscle reinnervation by muscle-nerve-muscle neurotization.

Journal Article Arch Otolaryngol Head Neck Surg · October 2001 OBJECTIVE: To determine if selective reinnervation of the cricothyroid muscle could be achieved with muscle-nerve-muscle neurotization. DESIGN: Case series. SETTING: Tertiary referral center. PATIENTS: Three consecutive patients with high vagal lesions tha ... Full text Link to item Cite

Laryngeal transplantation and 40-month follow-up.

Journal Article N Engl J Med · May 31, 2001 Full text Link to item Cite

Primary radiation therapy for early glottic cancer.

Journal Article Otolaryngol Head Neck Surg · January 2001 OBJECTIVES/HYPOTHESIS: Early glottic squamous cell carcinoma can be effectively treated with either radiation or surgical intervention. We evaluated our experience treating early glottic cancer with primary radiation therapy and our vertical hemilaryngecto ... Full text Link to item Cite

Ischemia/reperfusion injury in microvascular surgery.

Journal Article Head Neck · October 2000 Ischemia/reperfusion injury is often the final and irreversible factor causing flap failure in microvascular surgery for head and neck defects. This paper begins with a detailed review of flap physiology and ischemia/reperfusion injury at the cellular leve ... Full text Link to item Cite

Systemic adoptive T-cell immunotherapy in recurrent and metastatic carcinoma of the head and neck: a phase 1 study.

Journal Article Arch Otolaryngol Head Neck Surg · October 2000 OBJECTIVE: To evaluate the feasibility and toxic effects of systemic adoptive T-cell immunotherapy in patients with unresectable squamous cell carcinoma of the head and neck (SCCHN). DESIGN: Nonrandomized phase 1 clinical trial. SETTING: Academic tertiary ... Full text Link to item Cite

Evaluating laryngotracheal stenosis in a canine model with virtual bronchoscopy.

Journal Article Ann Otol Rhinol Laryngol · October 2000 We performed a prospective masked animal study to determine whether virtual bronchoscopy, a noninvasive computed tomography technique, can accurately measure upper airway stenosis. Virtual bronchoscopy creates a 3-dimensional endoscopic image from spiral c ... Full text Link to item Cite

Voice-related quality of life (V-RQOL) following type I thyroplasty for unilateral vocal fold paralysis.

Journal Article J Voice · September 2000 Unilateral vocal fold paralysis is a common clinical problem which frequently causes severe dysphonia. Various treatment options exist for this condition, with the type I thyroplasty being one of the more commonly performed surgical procedures for vocal re ... Full text Link to item Cite

Pain, quality of life, and spinal accessory nerve status after neck dissection.

Journal Article Laryngoscope · April 2000 OBJECTIVE: To assess quality of life (QOL) in patients with head and neck cancer who underwent neck dissection and to compare QOL scores for patients in whom the spinal accessory nerve (CN XI) was resected or preserved. SETTING AND DESIGN AND OUTCOMES MEAS ... Full text Link to item Cite

Improved canine model for laryngotracheal stenosis.

Journal Article Otolaryngol Head Neck Surg · January 2000 Laryngotracheal stenosis (LTS) is a serious challenge for the otolaryngologist. Although progress has been made in preventing and treating LTS, more research is required. Existing canine models for LTS incur high mortality and morbidity, require relatively ... Full text Link to item Cite

Can topical mitomycin prevent laryngotracheal stenosis?

Journal Article Laryngoscope · October 1999 OBJECTIVES/HYPOTHESIS: Early topical application of mitomycin to a laryngotracheal lesion may prevent or reduce laryngotracheal stenosis (LTS). STUDY DESIGN: Prospective controlled animal study. METHODS: LTS was induced in 60 dogs randomly assigned to four ... Full text Link to item Cite

The pathogenesis of vascular thrombosis and its impact in microvascular surgery.

Journal Article Head Neck · July 1999 As the use of free tissue transfer becomes more wide-spread, it is important for both the ablative surgeon and the reconstructive surgeon to understand the factors that contribute to successful revascularized tissue transfer. The purpose of this two part r ... Full text Link to item Cite

Health impact of head and neck cancer.

Journal Article Otolaryngol Head Neck Surg · June 1999 A multidimensional Head and Neck Quality of Life (HNQOL) instrument and a general health status measure were administered to 397 patients with head and neck cancer. Scores for the 4 domains of the HNQOL (communication, eating, pain, and emotional well-bein ... Full text Link to item Cite

Use of a revascularized, tubed costal myoperiosteal graft for repair of circumferential, segmental tracheal defects.

Journal Article Otolaryngol Head Neck Surg · May 1999 Reconstruction of extensive laryngotracheal stenosis continues to pose a significant surgical challenge. Previous work in our laboratory has demonstrated the utility of vascularized perichondrium for reconstruction of cervical tracheal defects in a rabbit ... Full text Link to item Cite

Long-term growth of a vascularized auricular perichondrocutaneous flap in laryngotracheal reconstruction.

Journal Article Otolaryngol Head Neck Surg · May 1999 This study addresses the potential for ongoing cartilage proliferation after repair of laryngotracheal stenosis with vascularized perichondrium. We randomly assigned 32 New Zealand white rabbits to 1 of 3 groups: group 1 (early cartilage growth, n = 10), g ... Full text Link to item Cite

Incidence and management of tension pneumocephalus after anterior craniofacial resection: case reports and review of the literature.

Journal Article Otolaryngol Head Neck Surg · April 1999 Full text Link to item Cite

Squamous cell carcinoma of the buccal mucosa.

Journal Article Otolaryngol Head Neck Surg · March 1999 The purpose of this study was to establish treatment criteria for patients with early-stage squamous cell carcinoma of the buccal mucosa. Thirty-one patients were analyzed in a retrospective fashion. Distribution of patients according to tumor stage was re ... Full text Link to item Cite

Adenoid cystic carcinoma of the paranasal sinuses.

Journal Article Am J Rhinol · 1999 Adenoid cystic carcinoma of the paranasal sinuses is a rare neoplasm whose propensity for perineural spread frequently results in positive surgical margins at the skull base. Radiation therapy (RT) may be used to treat unresectable tumors or as an adjuvant ... Full text Link to item Cite

Surgical variables affecting speech in treated patients with oral and oropharyngeal cancer.

Journal Article Laryngoscope · June 1998 Postoperative speech function may be influenced by a number of treatment variables. The objective of this study was to examine the relationships among various treatment factors to determine the impact of these measures on speech function. Speech function w ... Full text Link to item Cite

Laryngotracheal reconstruction

Journal Article Current Opinion in Otolaryngology and Head and Neck Surgery · October 30, 1997 The management of complex laryngotracheal stenosis continues to be a formidable challenge. This paper reviews recent advances in the areas of adjunctive medical measures to improve the success of laryngotracheal reconstruction, new surgical techniques, and ... Full text Cite

Head and neck cancer-specific quality of life: instrument validation.

Journal Article Arch Otolaryngol Head Neck Surg · October 1997 BACKGROUND: The disfigurement and dysfunction associated with head and neck cancer affect emotional well-being and some of the most basic functions of life. Most cancer-specific quality-of-life assessments give a single composite score for head and neck ca ... Full text Link to item Cite

Clinical outcome of continuous facial nerve monitoring during primary parotidectomy.

Journal Article Arch Otolaryngol Head Neck Surg · October 1997 OBJECTIVES: To assess whether continuous facial nerve monitoring during parotidectomy is associated with a lower incidence of facial nerve paresis or paralysis compared with parotidectomy without monitoring and to assess the cost of such monitoring. DESIGN ... Full text Link to item Cite

Repair of a complete glottic-subglottic stenosis with a fibular osseocutaneous free flap.

Journal Article Arch Otolaryngol Head Neck Surg · August 1997 Reconstruction of extensive laryngotracheal stenosis remains a formidable challenge. The ideal reconstructive technique has not been found because of the variability in the complexity and degree of laryngotracheal stenosis and the challenge of wound healin ... Full text Link to item Cite

Planned early neck dissection before radiation for persistent neck nodes after induction chemotherapy.

Journal Article Laryngoscope · August 1997 Optimal management of advanced neck metastases as part of an organ preservation treatment approach for head and neck squamous carcinoma (HNSC) is unclear. Since 1989, our management paradigm for patients on organ preservation was modified to incorporate pl ... Full text Link to item Cite

CaN19 expression in benign and malignant hyperplasias of the skin and oral mucosa: evidence for a role in regenerative differentiation.

Journal Article Cancer Res · July 15, 1997 CaN19, a member of the S100 family of calcium-binding proteins, is known to be "underexpressed" in cultured breast carcinoma-derived cell lines relative to their normal counterparts. By Northern blotting, we confirm these results and find that CaN19 is als ... Link to item Cite

Frequent loss of heterozygosity on chromosome arm 18q in squamous cell carcinomas. Identification of 2 regions of loss--18q11.1-q12.3 and 18q21.1-q23.

Journal Article Arch Otolaryngol Head Neck Surg · June 1997 OBJECTIVES: To determine the frequency and regions of loss on chromosome arm 18q in uncultured head and neck squamous cell carcinomas. DESIGN: Polymerase chain reaction amplification of DNA extracted from 18 tumor specimens (1 patient had 2 tumors) and blo ... Full text Link to item Cite

Impaired vocal cord mobility in the setting of acute suppurative thyroiditis.

Journal Article Head Neck · May 1997 BACKGROUND: Acute suppurative thyroiditis is an increasingly rare entity, accounting for less than 0.1% of thyroid surgery. This is the first report in the literature of acute thyroiditis causing a unilateral reversible vocal cord paralysis. METHODS: A 41- ... Full text Link to item Cite

Anterior ischemic optic neuropathy following neck dissection.

Journal Article Head Neck · March 1997 BACKGROUND: Ischemic optic neuropathy (ION) is a rare but devastating complication of surgery. It has traditionally been associated with intraoperative hypotension in patients with underlying arteriosclerosis. METHODS: We present a case of ION following bi ... Full text Link to item Cite

Effect of intraoperative ischemia on chondrogenesis by vascularized auricular perichondrium grafted in the airway.

Journal Article Ann Otol Rhinol Laryngol · March 1997 Vascularized perichondrium and periosteum are potentially ideal grafts for airway reconstruction. We quantitatively evaluated the effect of a 2-hour interruption of blood supply on subsequent growth of cartilage from vascularized auricular perichondrium gr ... Full text Link to item Cite

Skin graft reconstruction of the composite resection defect - Comment

Other HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK · November 1, 1996 Link to item Cite

Parotid gland sparing in patients undergoing bilateral head and neck irradiation: techniques and early results.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 1996 PURPOSE: To minimize xerostomia in patients receiving bilateral head and neck irradiation (RT) by using conformal RT planning to spare a significant volume of one parotid gland from radiation. METHODS AND MATERIALS: The study involved 15 patients with head ... Full text Link to item Cite

Chemotherapy followed by accelerated fractionated radiation for larynx preservation in patients with advanced laryngeal cancer.

Journal Article J Clin Oncol · August 1996 PURPOSE: Larynx preservation in advanced, resectable laryngeal cancer may be achieved using induction chemotherapy (CT) followed in responding patients by definitive radiation (RT). To address potential accelerated repopulation of clonogenic tumor cells du ... Full text Link to item Cite

Preoperative vascular imaging for the fibular osteocutaneous flap.

Journal Article Arch Otolaryngol Head Neck Surg · July 1996 The fibular osteocutaneous free flap has become a well-accepted method of mandibular reconstruction. Aberrations in the blood supply to the foot affect 5% to 7% of the population, and substantial atherosclerotic disease of the lower extremities is often fo ... Full text Link to item Cite

Reconstruction of the rabbit trachea with vascularized auricular perichondrium.

Journal Article Ann Otol Rhinol Laryngol · May 1996 Success in laryngotracheal reconstruction has been limited, in part, by the lack of an ideal grafting material. Perichondrium is thin, pliable, and highly vascularized and has the ability to generate new cartilage providing rigid support. These qualities m ... Full text Link to item Cite

Botulinum toxin injection for postlaryngectomy tracheoesophageal speech failure.

Journal Article Otolaryngol Head Neck Surg · December 1995 Full text Link to item Cite

Human papillomavirus types important in progression of inverted papilloma.

Journal Article Otolaryngol Head Neck Surg · November 1995 Recent evidence suggests that human papillomavirus may play a role in the pathogenesis of inverted papilloma, a benign but locally aggressive neoplasm with a high recurrence rate and an association with squamous cell carcinoma. Histologic features of inver ... Full text Link to item Cite

Vascularized auricular perichondrium in airway reconstruction: the effects of stenting with and without a mucosal graft.

Journal Article Laryngoscope · October 1995 This study quantitatively examines the effects of laryngotracheal stenting with and without mucosal grafting on chondrogenesis in a rabbit model. Vascularized auricular perichondrium was transferred to a cricothyroid membrane (CTM) defect in three groups o ... Full text Link to item Cite

Presence of human papillomavirus predicts recurrence of inverted papilloma.

Journal Article Otolaryngol Head Neck Surg · July 1995 Recent evidence suggests that human papillomavirus may play a role in the pathogenesis of inverted papilloma, a benign but locally aggressive neoplasm with a high recurrence rate and an association with squamous cell carcinoma. Histologic features of inver ... Full text Link to item Cite

Prevention of venous thrombosis in microvascular surgery by transmural release of heparin from a polyanhydride polymer.

Journal Article Surgery · May 1995 BACKGROUND: The effects of transmurally released heparin on the patency of microvenous anastomoses were studied by using a bioerodible polymer delivery system in a rat microvascular thrombosis model. METHODS: A polyanhydride carrier with heparin was wrappe ... Full text Link to item Cite

Atypical myosin heavy chain in rat laryngeal muscle.

Journal Article Ann Otol Rhinol Laryngol · March 1995 The myosin content of rat posterior cricoarytenoid and thyroarytenoid muscles was described by means of histochemical, immunohistochemical, and electrophoretic techniques. Laryngeal muscles were dissected and frozen, together with other muscles (extraocula ... Full text Link to item Cite

Squamous cell carcinoma arising in inverted papilloma.

Journal Article Laryngoscope · February 1995 A retrospective review of all cases of inverted papilloma at the University of Michigan from 1975 to 1992 revealed 51 cases of inverted papilloma. Of these, 14 (27%) had an associated squamous cell carcinoma (SCC). Eight (16%) were metachronous and 6 (11%) ... Full text Link to item Cite

Surgery after organ preservation therapy. Analysis of wound complications.

Journal Article Arch Otolaryngol Head Neck Surg · February 1995 OBJECTIVE: To determine the incidence and risk factors for the development of major wound complications in patients with squamous cell cancer of the head and neck that require surgical salvage after an initial treatment regimen of induction chemotherapy an ... Full text Link to item Cite

Chondrogenesis by free and vascularized rabbit auricular perichondrium.

Journal Article Ann Otol Rhinol Laryngol · November 1994 Many qualitative studies examining the chondrogenic potential of perichondrium have suggested that it may be useful for airway reconstruction. This study was performed to quantitatively evaluate cartilage formation by free and vascularized rabbit perichond ... Full text Link to item Cite

Hemilaryngectomy for glottic carcinoma after radiation therapy failure.

Journal Article Arch Otolaryngol Head Neck Surg · September 1994 OBJECTIVE: To determine the efficacy and safety of vertical hemilaryngectomy (VHL) for the treatment of early glottic carcinoma recurrent after radiation therapy (RT). DESIGN: Retrospective study. SETTING: Major referral center. PATIENTS: Forty patients we ... Full text Link to item Cite

Intensive induction chemotherapy and radiation for organ preservation in patients with advanced resectable head and neck carcinoma.

Journal Article J Clin Oncol · May 1994 PURPOSE: We designed a protocol to evaluate the possibility of organ preservation in patients with advanced, resectable carcinoma of the head and neck. The regimen consisted of intensive chemotherapy followed by radiation therapy alone for patients with go ... Full text Link to item Cite

Laryngeal liposarcoma.

Journal Article Arch Otolaryngol Head Neck Surg · April 1994 Laryngeal liposarcomas are rare, with only 13 previously well-documented cases (to our knowledge). We report an additional case, which documents the use of computed tomography for treatment planning. Laryngeal liposarcomas appear to have a better prognosis ... Full text Link to item Cite

Amyloidoma of the neck: case report and review of the literature.

Journal Article Head Neck · 1994 We present a case report of reactive amyloidoma of the neck in a patient with chronic calcaneal osteomyelitis. Localized deposits of amyloid may occur throughout the upper aerodigestive tract, but are rarely observed in the soft tissues of the neck. This i ... Full text Link to item Cite

Analysis of recurrence, complications, and functional results with free jejunal flaps.

Journal Article Head Neck · 1994 The medical records of 20 patients undergoing revascularized jejunal flap reconstruction of hypopharyngeal defects were retrospectively reviewed to analyze the incidence of distal marginal recurrence, complication rates, and success of early functional res ... Full text Link to item Cite

Comparison of the chondrogenic potential of free and vascularized perichondrium in the airway.

Journal Article Ann Otol Rhinol Laryngol · January 1994 Revascularized perichondrium or periosteum may be the ideal graft to repair severe laryngotracheal stenosis because of its pliability, potential for bone or cartilage formation, resistance to infection, and rapid mucosalization. To begin our evaluation of ... Full text Link to item Cite

The platysma myocutaneous flap. Indications and caveats.

Journal Article Arch Otolaryngol Head Neck Surg · January 1994 The platysma myocutaneous flap has enjoyed limited popularity despite its versatility, dependability, and ease of harvesting. In this article, we describe 12 consecutive patients who underwent platysma flap reconstruction of various oral cavity and orophar ... Full text Link to item Cite

Infantile myofibromatosis: a commonly misdiagnosed entity.

Journal Article Otolaryngol Head Neck Surg · October 1993 Full text Link to item Cite

Voice rehabilitation after total laryngectomy and tracheoesophageal puncture using nonmuscle closure.

Journal Article Ann Otol Rhinol Laryngol · October 1993 The successful production of voice with a tracheoesophageal puncture (TEP) and voice prosthesis requires a compliant pharyngoesophageal segment. Speech failure is commonly attributed to spasm of the pharyngoesophageal segment. During total laryngectomy (TL ... Full text Link to item Cite

Ionized serum calcium levels following combined treatment for cancer of the head and neck.

Journal Article Laryngoscope · September 1993 Thyroid function may be reduced after treatment of cancer of the head and neck, and hypothyroidism is much more common after combination therapy. Whether hypoparathyroidism and subsequent hypocalcemia also occur after such treatment is unknown. Few related ... Full text Link to item Cite

Correlation between the laryngeal brain stem evoked response and the laryngeal chemoreflex in the porcine model.

Journal Article Ann Otol Rhinol Laryngol · February 1993 The laryngeal brain stem evoked response (LBR) represents the neural activity involved in laryngeal reflex pathways. The laryngeal chemoreflex (LCR) is a centrally mediated response consisting of apnea and hemodynamic changes that result from laryngeal sti ... Full text Link to item Cite

Extracapsular spread and the perineural extension of squamous cell cancer in the cervical plexus.

Journal Article Arch Otolaryngol Head Neck Surg · November 1992 Extracapsular spread of squamous cell carcinoma in cervical lymph nodes is associated with approximately 50% decrease in survival and a twofold increase in regional recurrence. This study examines the hypothesis that increased regional recurrence may be, i ... Full text Link to item Cite

Monitoring of revascularized jejunal autografts.

Journal Article Arch Otolaryngol Head Neck Surg · October 1992 Free jejunal autografts have been widely used to reconstruct circumferential pharyngeal defects in a single stage. Close postoperative monitoring of the perfusion of the free jejunal autograft is extremely important in achieving a successful outcome. Prese ... Full text Link to item Cite

The role of cricothyroidotomy in airway management.

Journal Article Clin Chest Med · September 1991 Cricothyroidotomy as a method of elective airway management, previously shunned by Jackson, was reintroduced to the medical community in 1976. This article examines available data indicating the utility and complications of elective cricothyroidotomy for l ... Link to item Cite

Effect of local hypothermia on early wound repair.

Journal Article Arch Otolaryngol Head Neck Surg · July 1990 Local hypothermia has been shown to enhance survival of pedicled skin flaps. The effect of prolonged local hypothermia on an important clinical correlate, wound healing, is examined in this study. Skin incisions were made on each flank of nine female pigs, ... Full text Link to item Cite

Efficacy of steroids and hyperbaric oxygen on survival of dorsal skin flaps in rats.

Journal Article Otolaryngol Head Neck Surg · January 1990 This study was designed to determine if steroids improved skin flap survival in rats, and if steroids and hyperbaric oxygen (HBO) showed an additive beneficial effect. Cranially based, 3 x 9 cm dorsal skin flaps were raised in 60 adult rats. All animals re ... Full text Link to item Cite

Z-plasty modification of the Lynch incision.

Journal Article Laryngoscope · September 1989 Full text Link to item Cite

Identification of a secreted Mr 95,000 glycoprotein in human melanocytes and melanomas by a melanocyte specific monoclonal antibody.

Journal Article Cancer Res · March 1, 1988 We have isolated a monoclonal antibody, designated HMB-50, that is highly specific for melanomas and melanocyte derived lesions. The antibody recognizes melanomas, neonatal melanocytes, and junctional nevi but does not react with adult melanocytes, dermal ... Link to item Cite

Laryngotracheal foreign bodies in children. A comparison with bronchial foreign bodies.

Journal Article Am J Dis Child · March 1987 Twenty cases of laryngotracheal foreign bodies were reviewed over an 11-year period to determine features that differentiate these from bronchial foreign bodies. A history of choking or aspiration was obtained in 18 patients (90%). The most common presenti ... Full text Link to item Cite

Unique proteins defined by monoclonal antibodies specific for human melanoma. Some potential clinical applications.

Journal Article Am J Surg · October 1986 A panel of monoclonal antibodies, designated HMB 18, 45, and 50, have been isolated that are highly specific for malignant melanoma. When tested on fixed, paraffin-embedded tissue sections, they reacted with 97 percent of melanomas tested (58 of 60), inclu ... Full text Link to item Cite