Scholars@Duke
Sheng Luo

Sheng Luo CV

Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
sheng.luo@duke.edu
Duke Box 2721, Durham, NC 27710
2424 Erwin Road, Suite 1102, 11082 Hock Plaza, Durham, NC 27705
CV

Selected Publications

Validating new symptom emergence as a patient-centric outcome measure for PD clinical trials.

Journal Article Parkinsonism Relat Disord · November 2024 INTRODUCTION: Tracking of emergent symptoms (ES) in de novo Parkinson Disease (PD) patients using Parts Ib and II of the MDS-UPDRS rating scale has been proposed as an outcome measure for PD clinical trials, based on observations in the Safety, Tolerabilit ... Full text Link to item Cite

Virtual Lung Screening Trial (VLST): An In Silico Replica of the National Lung Screening Trial for Lung Cancer Detection.

Journal Article ArXiv · October 28, 2024 IMPORTANCE: Clinical imaging trials are crucial for evaluation of medical innovations, but the process is inefficient, expensive, and ethically-constrained. Virtual imaging trial (VIT) approach addresses these limitations by emulating the components of a c ... Link to item Cite

Validation of the Portuguese MDS-UPDRS: Challenges to Obtain a Scale Applicable to Different Linguistic Cultures.

Journal Article Mov Disord Clin Pract · October 26, 2024 BACKGROUND: The MDS-UPDRS has been available in English since 2008, showing satisfactory clinimetric results and being proposed as the new official benchmark scale for Parkinson's disease (PD), being cited as a core instrument for PD in the National Instit ... Full text Link to item Cite

Increasing Sensitivity in Patient-Reported MDS-UPDRS Items for Predicting Medication Initiation in Early PD.

Journal Article Mov Disord Clin Pract · October 18, 2024 BACKGROUND: The MDS-UPDRS Parts IB and II are self-reported items providing a direct patient voice to the experiences of PD. OBJECTIVE: To determine the most sensitive combination of MDS-UPDRS Parts IB and II items that accurately predicted the clinically ... Full text Link to item Cite

Projection-based two-sample inference for sparsely observed multivariate functional data.

Journal Article Biostatistics · October 1, 2024 Modern longitudinal studies collect multiple outcomes as the primary endpoints to understand the complex dynamics of the diseases. Oftentimes, especially in clinical trials, the joint variation among the multidimensional responses plays a significant role ... Full text Link to item Cite

Improving Parkinson's Disease Care through Systematic Screening for Depression.

Journal Article Mov Disord Clin Pract · October 2024 BACKGROUND: Depression is common in Parkinson's disease (PD) but is underrecognized clinically. Although systematic screening is a recommended strategy to improve depression recognition in primary care practice, it has not been widely used in PD care. METH ... Full text Link to item Cite

Potentially functional variants of PARK7 and DDR2 in ferroptosis-related genes predict survival of non-small cell lung cancer patients.

Journal Article Int J Cancer · September 25, 2024 Ferroptosis, a form of regulated cell death, is characterized by iron-dependent lipid peroxidation. It is recognized increasingly for its pivotal role in both cancer development and the response to cancer treatments. We assessed associations between 370,02 ... Full text Link to item Cite

Unmasking the sky: high-resolution PM2.5 prediction in Texas using machine learning techniques.

Journal Article J Expo Sci Environ Epidemiol · September 2024 BACKGROUND: Although PM2.5 (fine particulate matter with an aerodynamic diameter less than 2.5 µm) is an air pollutant of great concern in Texas, limited regulatory monitors pose a significant challenge for decision-making and environmental studies. OBJECT ... Full text Open Access Link to item Cite

Clinical efficacy of CDK4/6 inhibitor plus endocrine therapy in HR-positive/HER2-0 and HER2-low-positive metastatic breast cancer: a secondary analysis of PALOMA-2 and PALOMA-3 trials.

Journal Article EBioMedicine · July 2024 BACKGROUND: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors in combination with traditional endocrine therapy (ET) are now the recommended first-line treatment for hormone receptor (HR)-positive and HER2-negative metastatic breast cancer (MBC). However, th ... Full text Link to item Cite

Supplementing Best Care with Specialized Rehabilitation Treatment in Parkinson's Disease: A Retrospective Study by Different Expert Centers.

Journal Article J Clin Med · May 20, 2024 Background: This is a retrospective longitudinal study comparing 374 patients with Parkinson's disease (PD) who were treated in centers offering a specialized program of enhanced rehabilitation therapy in addition to expert outpatient care to 387 patients ... Full text Link to item Cite

A systematic assessment and optimization of photon-counting CT for lung density quantifications.

Journal Article Med Phys · April 2024 BACKGROUND: Photon-counting computed tomography (PCCT) has recently emerged into clinical use; however, its optimum imaging protocols and added benefits remains unknown in terms of providing more accurate lung density quantification compared to energy-inte ... Full text Open Access Link to item Cite

Predicting health outcomes with intensive longitudinal data collected by mobile health devices: a functional principal component regression approach.

Journal Article BMC Med Res Methodol · March 17, 2024 BACKGROUND: Intensive longitudinal data (ILD) collected in near real time by mobile health devices provide a new opportunity for monitoring chronic diseases, early disease risk prediction, and disease prevention in health research. Functional data analysis ... Full text Open Access Link to item Cite

Impact of HER2-low status for patients with early-stage breast cancer and non-pCR after neoadjuvant chemotherapy: a National Cancer Database Analysis.

Journal Article Breast Cancer Res Treat · February 2024 PURPOSE: To investigate potential differences in pathological complete response (pCR) rates and overall survival (OS) between HER2-low and HER2-zero patients with early-stage hormone receptor (HR)-positive and triple-negative breast cancer (TNBC), in the n ... Full text Open Access Link to item Cite

Impact of primary tumor resection and metastasectomy among gastroentero-pancreatic neuroendocrine tumors with liver metastases only on survival.

Journal Article HPB (Oxford) · January 2024 BACKGROUND: Despite recommendations for primary tumor resection (PTR) with or without liver resection (LR) in the patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and isolated liver metastases, there are conflicting data for their impa ... Full text Open Access Link to item Cite

Ethnoracial differences for caregiving burden in Parkinson's disease.

Journal Article Parkinsonism Relat Disord · January 2024 INTRODUCTION: Caregivers play an important role in Parkinson's disease (PD) treatment, especially as the disease progresses. As the symptom profile and needs of people with PD (PwP) differ across ethnoracial groups, whether caregiving needs also differ for ... Full text Open Access Link to item Cite

Validation of the Kazakh version of the movement disorder Society-Unified Parkinson's disease rating scale.

Journal Article Clin Park Relat Disord · 2024 BACKGROUND AND PURPOSE: The International Movement Disorder Society revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is widely used in the assessment of the severity of Parkinson's disease (PD). This study aimed to validate the Kazakh v ... Full text Open Access Link to item Cite

Assessing tilavonemab efficacy in early Alzheimer's disease via longitudinal item response theory modeling.

Journal Article Alzheimers Dement (N Y) · 2024 INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by declines in cognitive and functional severities. This research utilized the Clinical Dementia Rating (CDR) to assess the influence of tilavonemab on these deterioration ... Full text Open Access Link to item Cite

Appropriate dose of regorafenib based on body weight of colorectal cancer patients: a retrospective cohort study.

Journal Article BMC Cancer · December 21, 2023 PURPOSE: Previous randomized studies have shown a survival benefit of using regorafenib but a high rate of adverse events in unresectable colorectal cancer patients. To reduce these adverse events and improve the tolerability, we examined the appropriate d ... Full text Open Access Link to item Cite

Adverse Events of Immune Checkpoint Inhibitor-Based Therapies for Unresectable Hepatocellular Carcinoma in Prospective Clinical Trials: A Systematic Review and Meta-Analysis.

Journal Article Liver Cancer · December 2023 BACKGROUND: The aim of the study was to investigate the incidence and spectrum of adverse events in unresectable hepatocellular carcinoma (HCC) patients treated with immune checkpoint inhibitors (ICIs) or ICI-based combinations. SUMMARY: The study protocol ... Full text Open Access Link to item Cite

Impact of surgical approach on short- and long-term outcomes in gastroenteropancreatic neuroendocrine carcinomas.

Journal Article HPB (Oxford) · October 2023 BACKGROUND: Literature is lacking on the impact of advancements in minimally invasive surgery (MIS) on outcomes for patients with gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs). Herein, we compared perioperative and oncologic outcomes among pa ... Full text Open Access Link to item Cite

BAYESIAN INFERENCE AND DYNAMIC PREDICTION FOR MULTIVARIATE LONGITUDINAL AND SURVIVAL DATA.

Journal Article Ann Appl Stat · September 2023 Alzheimer's disease (AD) is a complex neurological disorder impairing multiple domains such as cognition and daily functions. To better understand the disease and its progression, many AD research studies collect multiple longitudinal outcomes that are str ... Full text Open Access Link to item Cite

Racial and Ethnic Differences in Health-Related Quality of Life for Individuals With Parkinson Disease Across Centers of Excellence.

Journal Article Neurology · May 23, 2023 BACKGROUND AND OBJECTIVES: Racial and ethnic minorities have been underrepresented in Parkinson disease (PD) research, limiting our understanding of treatments and outcomes across all non-White groups. The goal of this research is to investigate variabilit ... Full text Open Access Link to item Cite

Multivariate functional mixed model with MRI data: An application to Alzheimer's disease.

Journal Article Stat Med · May 10, 2023 Alzheimer's Disease (AD) is the leading cause of dementia and impairment in various domains. Recent AD studies, (ie, Alzheimer's Disease Neuroimaging Initiative (ADNI) study), collect multimodal data, including longitudinal neurological assessments and mag ... Full text Open Access Link to item Cite

Primary tumor resection improves survival of gastrointestinal neuroendocrine carcinoma patients with nonresected liver metastases.

Journal Article J Surg Oncol · May 2023 BACKGROUND: The role of primary tumor resection (PTR) in the survival of gastrointestinal neuroendocrine carcinoma (GI-NEC) patients with liver metastases only remains poorly defined. Therefore, we investigated the impact of PTR on the survival of GI-NEC p ... Full text Open Access Link to item Cite

Expanded and Independent Spanish Validation of the MDS-Non Motor Rating Scale.

Journal Article Mov Disord Clin Pract · April 2023 BACKGROUND: The Movement Disorder Society-sponsored Non-motor Rating Scale (MDS-NMS) assess the severity and disability caused by non-motor symptoms (NMS) in Parkinson's disease (PD). OBJECTIVE: This article encapsulates the formal process for completing t ... Full text Open Access Link to item Cite

Cross-Cultural Differences in Patient Perceptions of Dyskinesia in Parkinson's Disease.

Journal Article Mov Disord · April 2023 BACKGROUND: The prevalence of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD) varies among geographical regions. Cultural differences in patient-based perceptions of LID have not been studied. OBJECTIVE: We compared patient and clinician eval ... Full text Open Access Link to item Cite

Genetics of Neurogenic Orthostatic Hypotension in Parkinson's Disease, Results from a Cross-Sectional In Silico Study.

Journal Article Brain Sci · March 17, 2023 The genetic basis of Neurogenic Orthostatic Hypotension (NOH) in Parkinson's disease (PD) has been inadequately explored. In a cross-sectional study, we examined the association between NOH and PD-related single-nucleotide polymorphisms (SNPs) and mapped t ... Full text Open Access Link to item Cite

MRI Quantification of Placebo Effect in Nonalcoholic Steatohepatitis Clinical Trials.

Journal Article Radiology · March 2023 Background Several early-phase clinical trials for the treatment of nonalcoholic steatohepatitis (NASH) use liver fat content as measured with the MRI-derived proton density fat fraction (PDFF) for a primary outcome. These trials have shown relative reduct ... Full text Open Access Link to item Cite

Using Movement Disorder Society Unified Parkinson's Disease Rating Scale Parts 2 and 3 Simultaneously: Combining the Patient Voice with Clinician Ratings.

Journal Article Mov Disord · March 2023 BACKGROUND: Regulatory recommendations favor outcomes combining objective and patient input. The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), the most commonly used scale in Parkinson's disease (PD), includes patient and ... Full text Open Access Link to item Cite

Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder.

Journal Article Autism Res · March 2023 Oxytocin (OT), the brain's most abundant neuropeptide, plays an important role in social salience and motivation. Clinical trials of the efficacy of OT in autism spectrum disorder (ASD) have reported mixed results due in part to ASD's complex etiology. We ... Full text Open Access Link to item Cite

Whole-Slide Cytometric Feature Mapping for Distinguishing Tumor Genomic Subtypes in Head and Neck Squamous Cell Carcinoma Whole-Slide Images.

Journal Article Am J Pathol · February 2023 Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease where, in advanced stages, clinical and pathologic stages do not correlate with outcome. Molecular and genomic biomarkers for HNSCC classification have shown promise for prognostic an ... Full text Open Access Link to item Cite

It Is as It Was: MDS-UPDRS Part III Scores Cannot Be Combined with Other Parts to Give a Valid Sum.

Journal Article Mov Disord · February 2023 BACKGROUND: Original clinimetric analyses by the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) developers did not confirm the validity of summing the scores of its parts. Recent studies used the su ... Full text Open Access Link to item Cite

Association and Trends in Medicare Denials and Utilization for Brain CT: Indirect Impacts by Targeted Policy Intervention?

Journal Article Curr Probl Diagn Radiol · 2023 Twenty-five years of annual Medicare Physician/Supplier Procedure Summary (PSPS) Master File data were used to assess trends in normalized volume and claim denial rates for brain computerized tomography. Alongside growth in utilization of brain computerize ... Full text Open Access Link to item Cite

Novel Genetic Variants in TP37, PIK3R1, CALM1, and PLCG2 of the Neurotrophin Signaling Pathway Are Associated with the Progression from Mild Cognitive Impairment to Alzheimer's Disease.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: Alzheimer's disease (AD) is a common neurodegenerative disease and mild cognitive impairment (MCI) is considered as the prodromal stage of AD. Previous studies showed that changes in the neurotrophin signaling pathway could lead to cognitive de ... Full text Open Access Link to item Cite

Genotypic Effects of the TOMM40'523 Variant and APOE on Longitudinal Cognitive Change over 4 Years: The TOMMORROW Study.

Journal Article J Prev Alzheimers Dis · 2023 BACKGROUND: The 523 poly-T length polymorphism (rs10524523) in TOMM40 has been reported to influence longitudinal cognitive test performance within APOE ε3/3 carriers. The results from prior studies are inconsistent. It is also unclear whether specific APO ... Full text Open Access Link to item Cite

Rationale and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia: UPDATe).

Journal Article Ann Med · December 2022 BACKGROUND: Limited data are available to establish evidence-based management protocols for vestibulodynia (VBD), a chronic vulvar pain condition that affects approximately 14 million women in the U.S. For the purposes of the study, our group subdivided VB ... Full text Open Access Link to item Cite

Application of longitudinal item response theory models to modeling Parkinson's disease progression.

Journal Article CPT Pharmacometrics Syst Pharmacol · October 2022 The Movement Disorder Society revised version of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) parts 2 and 3 reflect patient-reported functional impact and clinician-reported severity of motor signs of Parkinson's disease (PD), respectively. Tot ... Full text Open Access Link to item Cite

Genetic Association Between Epigenetic Aging-Acceleration and the Progression of Mild Cognitive Impairment to Alzheimer's Disease.

Journal Article J Gerontol A Biol Sci Med Sci · September 1, 2022 Alzheimer's disease (AD) is a progressive neurodegenerative disorder, and previous studies have shown its association with accelerated aging. In this study, we hypothesized that single nucleotide polymorphisms (SNPs) that contributed to aging acceleration ... Full text Open Access Link to item Cite

Resolving Missing Data from the Movement Disorder Society Unified Parkinson's Disease Rating Scale: Implications for Telemedicine.

Journal Article Mov Disord · August 2022 BACKGROUND: Telemedicine has become standard in clinical care and research during the coronavirus disease 2019 pandemic. Remote administration of Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III (Motor Examination) pr ... Full text Open Access Link to item Cite

Deep learning for the dynamic prediction of multivariate longitudinal and survival data.

Journal Article Stat Med · July 10, 2022 The joint model for longitudinal and survival data improves time-to-event predictions by including longitudinal outcome variables in addition to baseline covariates. However, in practice, joint models may be limited by parametric assumptions in both the lo ... Full text Open Access Link to item Cite

Neuropathological associations of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) differ between the oldest-old and younger-old.

Journal Article Acta Neuropathol · July 2022 Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is most often seen in the oldest-old (≥ 90 years of age) but can also be present in the younger-old (< 90 years of age). In this study, we compared the neuropathologica ... Full text Open Access Link to item Cite

Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival.

Journal Article Mol Carcinog · July 2022 Peroxisomes play a role in lipid metabolism and regulation of reactive oxygen species, but its role in development and progression of non-small cell lung cancer (NSCLC) is not well understood. Here, we investigated the associations between 9708 single-nucl ... Full text Open Access Link to item Cite

Joint model for survival and multivariate sparse functional data with application to a study of Alzheimer's Disease.

Journal Article Biometrics · June 2022 Studies of Alzheimer's disease (AD) often collect multiple longitudinal clinical outcomes, which are correlated and predictive of AD progression. It is of great scientific interest to investigate the association between the outcomes and time to AD onset. W ... Full text Open Access Link to item Cite

Validation of the Thai Version of the Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale.

Journal Article J Mov Disord · May 2022 OBJECTIVE: This study aims to validate the Thai translation of the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). METHODS: The English version was translated into Thai and then back-translated into ... Full text Open Access Link to item Cite

Effect of Exercise and Rehabilitation Therapy on Risk of Hospitalization in Parkinson's Disease.

Journal Article Mov Disord Clin Pract · May 2022 BACKGROUND: Exercise and physical therapy (PT) can improve motor function and quality of life in individuals with Parkinson's disease (PD), but their role in hospitalization avoidance is not well-studied. OBJECTIVES: To determine the longitudinal and tempo ... Full text Open Access Link to item Cite

Single nucleotide polymorphisms in FOXP1 and RORA of the lymphocyte activation-related pathway affect survival of lung cancer patients.

Journal Article Transl Lung Cancer Res · May 2022 BACKGROUND: Lymphocyte activation is part of a complex microenvironment that affects the development and progression of solid tumors. The present study analyzed the associations between genetic variants in lymphocyte activation-related genes and survival o ... Full text Open Access Link to item Cite

Validation of the Arabic Version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale.

Journal Article Mov Disord · April 2022 BACKGROUND: The Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) has become the gold standard for evaluating different domains in Parkinson's disease (PD), and it is commonly used in clinical practice, research, and clinical t ... Full text Open Access Link to item Cite

A pleiotropic ATM variant (rs1800057 C>G) is associated with risk of multiple cancers.

Journal Article Carcinogenesis · February 11, 2022 ATM (ataxia-telangiectasia mutated) is an important cell-cycle checkpoint kinase required for cellular response to DNA damage. Activated by DNA double strand breaks, ATM regulates the activities of many downstream proteins involved in various carcinogenic ... Full text Open Access Link to item Cite

Predicting outcomes after intradetrusor onabotulinumtoxina for non-neurogenic urgency incontinence in women.

Journal Article Neurourol Urodyn · January 2022 AIMS: Develop models to predict outcomes after intradetrusor injection of 100 or 200 units of onabotulinumtoxinA in women with non-neurogenic urgency urinary incontinence (UUI). METHODS: Models were developed using 307 women from two randomized trials asse ... Full text Open Access Link to item Cite

Polygenic Risk Score Effectively Predicts Depression Onset in Alzheimer's Disease Based on Major Depressive Disorder Risk Variants.

Journal Article Front Neurosci · 2022 INTRODUCTION: Depression is a common, though heterogenous, comorbidity in late-onset Alzheimer's Disease (LOAD) patients. In addition, individuals with depression are at greater risk to develop LOAD. In previous work, we demonstrated shared genetic etiolog ... Full text Open Access Link to item Cite

Clinically approved combination immunotherapy: Current status, limitations, and future perspective.

Journal Article Curr Res Immunol · 2022 Immune-checkpoint inhibitor-based combination immunotherapy has become a first-line treatment for several major types of cancer including hepatocellular carcinoma (HCC), renal cell carcinoma, lung cancer, cervical cancer, and gastric cancer. Combination im ... Full text Open Access Link to item Cite

Bayesian inference and dynamic prediction of multivariate joint model with functional data: An application to Alzheimer's disease.

Journal Article Stat Med · December 30, 2021 Alzheimer's disease (AD) is a severe neurodegenerative disorder impairing multiple domains, for example, cognition and behavior. Assessing the risk of AD progression and initiating timely interventions at early stages are critical to improve the quality of ... Full text Open Access Link to item Cite

Prognostic Modeling of Parkinson's Disease Progression Using Early Longitudinal Patterns of Change.

Journal Article Mov Disord · December 2021 BACKGROUND: Predicting Parkinson's disease (PD) progression may enable better adaptive and targeted treatment planning. OBJECTIVE: Develop a prognostic model using multiple, easily acquired longitudinal measures to predict temporal clinical progression fro ... Full text Open Access Link to item Cite

CT Radiomic Features of Superior Mesenteric Artery Involvement in Pancreatic Ductal Adenocarcinoma: A Pilot Study.

Journal Article Radiology · December 2021 Background Current imaging methods for prediction of complete margin resection (R0) in patients with pancreatic ductal adenocarcinoma (PDAC) are not reliable. Purpose To investigate whether tumor-related and perivascular CT radiomic features improve preope ... Full text Open Access Link to item Cite

Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder.

Journal Article N Engl J Med · October 14, 2021 BACKGROUND: Experimental studies and small clinical trials have suggested that treatment with intranasal oxytocin may reduce social impairment in persons with autism spectrum disorder. Oxytocin has been administered in clinical practice to many children wi ... Full text Open Access Link to item Cite

Potentially functional variants of ERAP1, PSMF1 and NCF2 in the MHC-I-related pathway predict non-small cell lung cancer survival.

Journal Article Cancer Immunol Immunother · October 2021 BACKGROUND: Cellular immunity against tumor cells is highly dependent on antigen presentation by major histocompatibility complex class I (MHC-I) molecules. However, few published studies have investigated associations between functional variants of MHC-I- ... Full text Open Access Link to item Cite

Association of genetic variants of FBXO32 and FOXO6 in the FOXO pathway with breast cancer risk.

Journal Article Mol Carcinog · October 2021 Forkhead box class O (FOXO) transcription factors play a pivotal role in regulating a variety of biological processes, including organismal development, cell signaling, cell metabolism, and tumorigenesis. Therefore, we hypothesize that genetic variants in ... Full text Open Access Link to item Cite

Novel Approach to Movement Disorder Society-Unified Parkinson's Disease Rating Scale Monitoring in Clinical Trials: Longitudinal Item Response Theory Models.

Journal Article Mov Disord Clin Pract · October 2021 BACKGROUND: Although nontremor and tremor Part 3 Movement Disorder Society-Unified Parkinson's Disease Rating Scale items measure different impairment domains, their distinct progression and drug responsivity remain unstudied longitudinally. The total scor ... Full text Open Access Link to item Cite

Genetic variants of SDCCAG8 and MAGI2 in mitosis-related pathway genes are independent predictors of cutaneous melanoma-specific survival.

Journal Article Cancer Sci · October 2021 Mitosis is a prognostic factor for cutaneous melanoma (CM), but accurate mitosis detection in CM tissues is difficult. Therefore, the 8th Edition of the American Joint Committee on Cancer staging system has removed the mitotic rate as a category criterion ... Full text Open Access Link to item Cite

Genetic variants of CHEK1, PRIM2 and CDK6 in the mitotic phase-related pathway are associated with nonsmall cell lung cancer survival.

Journal Article Int J Cancer · September 15, 2021 The mitotic phase is a vital step in cell division and may be involved in cancer progression, but it remains unclear whether genetic variants in mitotic phase-related pathways genes impact the survival of these patients. Here, we investigated associations ... Full text Open Access Link to item Cite

Use of Patient-Reported Outcomes Measurement Information System (PROMIS) measures to characterise health status for patients seeking care from an orthopaedic provider: a retrospective cohort study.

Journal Article BMJ Open · September 2, 2021 OBJECTIVES: Characterise the health status of patients newly consulting an orthopaedic specialist across eight clinical subspecialties. DESIGN: Retrospective cohort. SETTING: 18 orthopaedic clinics, including 8 subspecialties (14 ambulatory and 4 hospital ... Full text Open Access Link to item Cite

Adjuvant Chemotherapy Versus Observation Following Resection for Patients With Nonmetastatic Poorly Differentiated Colorectal Neuroendocrine Carcinomas.

Journal Article Ann Surg · August 1, 2021 OBJECTIVE: The aim of this study was to determine whether adjuvant chemotherapy (AC) provides a survival benefit in patients with nonmetastatic poorly differentiated colorectal neuroendocrine carcinomas (CRNECs) following resection. BACKGROUND: There is li ... Full text Open Access Link to item Cite

Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients.

Journal Article Transl Res · July 2021 The gonadotropin-releasing hormone (GnRH) signaling pathway controls reproductive functions and cancer growth and progression. However, few studies investigated roles of genetic variants of GnRH pathway genes in survival of patients with non-small cell lun ... Full text Open Access Link to item Cite

Can PROMIS measures be used to create subgroups for patients seeking orthopaedic care?

Journal Article Bone Jt Open · July 2021 AIMS: Patient-reported outcome measures have become an important part of routine care. The aim of this study was to determine if Patient-Reported Outcomes Measurement Information System (PROMIS) measures can be used to create patient subgroups for individu ... Full text Open Access Link to item Cite

Association of genetic variants of TMEM135 and PEX5 in the peroxisome pathway with cutaneous melanoma-specific survival.

Journal Article Ann Transl Med · March 2021 BACKGROUND: Peroxisomes are ubiquitous and dynamic organelles that are involved in the metabolism of reactive oxygen species (ROS) and lipids. However, whether genetic variants in the peroxisome pathway genes are associated with survival in patients with m ... Full text Open Access Link to item Cite

Automated Structured Reporting for Thyroid Ultrasound: Effect on Reporting Errors and Efficiency.

Journal Article J Am Coll Radiol · February 2021 PURPOSE: To compare the effectiveness of different reporting templates using the ACR Thyroid Imaging Reporting and Data System (TI-RADS) for thyroid ultrasound. METHODS: In this retrospective study, four radiologists implemented ACR TI-RADS while dictating ... Full text Open Access Link to item Cite

Dynamic prediction using joint models of longitudinal and recurrent event data: A Bayesian perspective.

Journal Article Biostat Epidemiol · 2021 In cardiovascular disease (CVD) studies, the events of interest may be recurrent (multiple occurrences from the same individual). During the study follow-up, longitudinal measurements are often available and these measurements are highly predictive of even ... Full text Open Access Link to item Cite

Functional survival forests for multivariate longitudinal outcomes: Dynamic prediction of Alzheimer's disease progression.

Journal Article Stat Methods Med Res · January 2021 The random survival forest (RSF) is a non-parametric alternative to the Cox proportional hazards model in modeling time-to-event data. In this article, we developed a modeling framework to incorporate multivariate longitudinal data in the model building pr ... Full text Open Access Link to item Cite

Validation of the Polish version of the Unified Dyskinesia Rating Scale (UDysRS).

Journal Article Neurol Neurochir Pol · 2021 BACKGROUND: In 2008, the Movement Disorders Society published the Unified Dyskinesia Rating Scale (UDysRS). This has become the established tool for assessing the severity and disability associated with dyskinesia in patients with Parkinson's Disease (PD). ... Full text Open Access Link to item Cite

Derivation of a Risk Assessment Tool for Prediction of Long-Term Pain Intensity Reduction After Physical Therapy.

Journal Article J Pain Res · 2021 RATIONALE: Risk assessment tools can improve clinical decision-making for individuals with musculoskeletal pain, but do not currently exist for predicting reduction of pain intensity as an outcome from physical therapy. AIMS AND OBJECTIVE: The objective of ... Full text Open Access Link to item Cite

Genetic variants of DOCK2, EPHB1 and VAV2 in the natural killer cell-related pathway are associated with non-small cell lung cancer survival.

Journal Article Am J Cancer Res · 2021 Although natural killer (NK) cells are a known major player in anti-tumor immunity, the effect of genetic variation in NK-associated genes on survival in patients with non-small cell lung cancer (NSCLC) remains unknown. Here, in 1,185 with NSCLC cases of a ... Open Access Link to item Cite

Validation of the Finnish Version of the Unified Dyskinesia Rating Scale.

Journal Article Eur Neurol · 2021 INTRODUCTION: The Unified Dyskinesia Rating Scale (UDysRS) was developed to provide a comprehensive rating tool of dyskinesia in Parkinson's disease (PD). Because dyskinesia therapy trials involve multicenter studies, having a scale that is validated in mu ... Full text Open Access Link to item Cite

Genetic Variants of CLEC4E and BIRC3 in Damage-Associated Molecular Patterns-Related Pathway Genes Predict Non-Small Cell Lung Cancer Survival.

Journal Article Front Oncol · 2021 Accumulating evidence supports a role of various damage-associated molecular patterns (DAMPs) in progression of lung cancer, but roles of genetic variants of the DAMPs-related pathway genes in lung cancer survival remain unknown. We investigated associatio ... Full text Open Access Link to item Cite

Association Between Polygenic Risk Score and the Progression from Mild Cognitive Impairment to Alzheimer's Disease.

Journal Article J Alzheimers Dis · 2021 BACKGROUND: Mild cognitive impairment (MCI) is a heterogeneous condition and MCI patients are at increased risk of progression to dementia due to Alzheimer's disease (AD). OBJECTIVE: In this study, we aim to evaluate the associations between polygenic risk ... Full text Open Access Link to item Cite

Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk.

Journal Article Cancer Med · December 2020 Because the cadherin-mediated signaling pathway promotes cancer progression, we assessed associations between genetic variants in 109 cadherin-related genes and risk of pancreatic cancer (PanC) by using genotyping data from publically available genome-wide ... Full text Open Access Link to item Cite

Genetic variants in the folate metabolic pathway genes predict cutaneous melanoma-specific survival.

Journal Article Br J Dermatol · October 2020 BACKGROUND: Folate metabolism plays an important role in DNA methylation and nucleic acid synthesis and thus may function as a regulatory factor in cancer development. Genome-wide association studies (GWASs) have identified some single-nucleotide polymorph ... Full text Open Access Link to item Cite

Longitudinal Monitoring of Pain Associated Distress With the Optimal Screening for Prediction of Referral and Outcome Yellow Flag Tool: Predicting Reduction in Pain Intensity and Disability.

Journal Article Arch Phys Med Rehabil · October 2020 OBJECTIVE: To investigate the Optimal Screening for Prediction of Referral and Outcome Yellow Flag (OSPRO-YF) tool for longitudinal monitoring of pain associated distress with the goal of improving prediction of 50% reduction in pain intensity and disabili ... Full text Open Access Link to item Cite

Potentially functional genetic variants in PLIN2, SULT2A1 and UGT1A9 genes of the ketone pathway and survival of nonsmall cell lung cancer.

Journal Article Int J Cancer · September 15, 2020 The ketone metabolism pathway is a principle procedure in physiological homeostasis and induces cancer cells to switch between glycolysis and oxidative phosphorylation for energy production. We conducted a two-phase analysis for associations between geneti ... Full text Open Access Link to item Cite

Item Response Theory Analysis of the MDS-UPDRS Motor Examination: Tremor vs. Nontremor Items.

Journal Article Mov Disord · September 2020 BACKGROUND: In PD, tremor severity behaves differently from other core motor features. However, the most commonly used assessment of overall motor severity, total MDS-UPDRS Motor Examination (Part 3) score, does not account for this distinction. OBJECTIVES ... Full text Open Access Link to item Cite

Shared genetic etiology underlying late-onset Alzheimer's disease and posttraumatic stress syndrome.

Journal Article Alzheimers Dement · September 2020 INTRODUCTION: Late-onset Alzheimer's disease (LOAD) manifests comorbid neuropsychiatric symptoms and posttraumatic stress disorder (PTSD) is associated with an increased risk for dementia in late life, suggesting the two disorders may share genetic etiolog ... Full text Open Access Link to item Cite

Genetic variants in TKT and DERA in the nicotinamide adenine dinucleotide phosphate pathway predict melanoma survival.

Journal Article Eur J Cancer · September 2020 BACKGROUND: Cutaneous melanoma (CM) is the most lethal type of skin cancers. Nicotinamide adenine dinucleotide phosphate (NADPH) plays an important role in anabolic reactions and tumorigenesis, but many genes are involved in the NADPH system. METHODS: We u ... Full text Open Access Link to item Cite

Generalized Linear Binning to Compare Hyperpolarized 129Xe Ventilation Maps Derived from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI.

Journal Article Acad Radiol · August 2020 RATIONALE: Hyperpolarized 129Xe ventilation MRI is typically acquired using multislice fast gradient recalled echo (GRE), but interleaved 3D radial 129Xe gas transfer MRI now provides dissolved-phase and ventilation images from a single breath. To investig ... Full text Open Access Link to item Cite

Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer.

Journal Article Mol Carcinog · August 2020 Because the peroxisome proliferator-activated receptor (PPAR) signaling pathway is involved in development and progression of pancreatic cancer, we investigated associations between genetic variants of the PPAR pathway genes and pancreatic cancer risk by u ... Full text Open Access Link to item Cite

Novel Variants of ELP2 and PIAS1 in the Interferon Gamma Signaling Pathway Are Associated with Non-Small Cell Lung Cancer Survival.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2020 BACKGROUND: IFNγ is a pleiotropic cytokine that plays critical immunomodulatory roles in intercellular communication in innate and adaptive immune responses. Despite recognition of IFNγ signaling effects on host defense against viral infection and its util ... Full text Open Access Link to item Cite

Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.

Journal Article Int J Cancer · July 15, 2020 The endosome is a membrane-bound organ inside most eukaryotic cells, playing an important role in adaptive immunity by delivering endocytosed antigens to both MHC class I and II pathways. Here, by analyzing genotyping data from two published genome-wide as ... Full text Open Access Link to item Cite

APOB Genotypes and CDH13 Haplotypes in the Cholesterol-Related Pathway Genes Predict Non-Small Cell Lung Cancer Survival.

Journal Article Cancer Epidemiol Biomarkers Prev · June 2020 BACKGROUND: Several oncogenic signals are involved in the synthesis, metabolism, transportation, and modulation of cholesterol. However, the roles of genetic variants of the cholesterol pathway genes in cancer survival remain unclear. METHODS: We investiga ... Full text Open Access Link to item Cite

Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma-specific survival.

Journal Article Mol Carcinog · June 2020 A few single-nucleotide polymorphisms (SNPs) have been identified to be associated with cutaneous melanoma (CM) survival through genome-wide association studies, but stringent multiple testing corrections required for the hypothesis-free testing may have m ... Full text Open Access Link to item Cite

Novel genetic variants in genes of the Fc gamma receptor-mediated phagocytosis pathway predict non-small cell lung cancer survival.

Journal Article Transl Lung Cancer Res · June 2020 BACKGROUND: Both antibody-dependent cellular cytotoxicity and phagocytosis activate innate immunity, and the Fc gamma receptor (FCGR)-mediated phagocytosis is an integral part of the process. We assessed associations between single-nucleotide polymorphisms ... Full text Open Access Link to item Cite

Correlation of preoperative imaging characteristics with donor outcomes and operative difficulty in laparoscopic donor nephrectomy.

Journal Article Am J Transplant · March 2020 This study aimed to understand the relationship of preoperative measurements and risk factors on operative time and outcomes of laparoscopic donor nephrectomy. Two hundred forty-two kidney donors between 2010 and 2017 were identified. Patients' demographic ... Full text Open Access Link to item Cite

The LI-RADS Version 2018 MRI Treatment Response Algorithm: Evaluation of Ablated Hepatocellular Carcinoma.

Journal Article Radiology · February 2020 Background The Liver Imaging Reporting and Data System (LI-RADS) treatment response algorithm (TRA) is used to assess presumed hepatocellular carcinoma (HCC) after local-regional therapy, but its performance has not been extensively assessed. Purpose To as ... Full text Open Access Link to item Cite

Novel Genetic Variants of ALG6 and GALNTL4 of the Glycosylation Pathway Predict Cutaneous Melanoma-Specific Survival.

Journal Article Cancers (Basel) · January 24, 2020 Because aberrant glycosylation is known to play a role in the progression of melanoma, we hypothesize that genetic variants of glycosylation pathway genes are associated with the survival of cutaneous melanoma (CM) patients. To test this hypothesis, we use ... Full text Open Access Link to item Cite

Novel genetic variants in HDAC2 and PPARGC1A of the CREB-binding protein pathway predict survival of non-small-cell lung cancer.

Journal Article Mol Carcinog · January 2020 The CREB-binding protein (CBP) pathway plays an important role in transcription and activity of acetyltransferase that acetylates lysine residues of histones and nonhistone proteins. In the present study, we hypothesized that genetic variants in the CBP pa ... Full text Open Access Link to item Cite

Fast Covariance Estimation for Multivariate Sparse Functional Data.

Journal Article Stat (Int Stat Inst) · 2020 Covariance estimation is essential yet underdeveloped for analyzing multivariate functional data. We propose a fast covariance estimation method for multivariate sparse functional data using bivariate penalized splines. The tensor-product B-spline formulat ... Full text Open Access Link to item Cite

Validation of the Hebrew Version of the Unified Dyskinesia Rating Scale.

Journal Article Neuroepidemiology · 2020 BACKGROUND: The Unified Dyskinesia Rating Scale (UDysRS) is a well-established tool for producing comprehensive assessments of severity and disability associated with dyskinesia in patients with Parkinson's disease (PD). The scale was originally developed ... Full text Open Access Link to item Cite

Novel genetic variants of KIR3DL2 and PVR involved in immunoregulatory interactions are associated with non-small cell lung cancer survival.

Journal Article Am J Cancer Res · 2020 Immunoregulatory interactions play a pivotal role in immune surveillance, recognition, and killing, particularly its internal pathway, likely playing an important role in immune escape. By using two genotyping datasets, one from the Prostate, Lung, Colorec ... Open Access Link to item Cite

Validation of the Polish version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS).

Journal Article Neurol Neurochir Pol · 2020 BACKGROUND: In 2008, the Movement Disorders Society (MDS) published a new Unified Parkinson's Disease Rating Scale (MDS-UPDRS) as the official benchmark scale for Parkinson's Disease (PD). We have translated and validated the Polish version of the MDS-UPDR ... Full text Open Access Link to item Cite

Variants in SNAI1, AMDHD1 and CUBN in vitamin D pathway genes are associated with breast cancer risk: a large-scale analysis of 14 GWASs in the DRIVE study.

Journal Article Am J Cancer Res · 2020 Vitamin D has a potential anticarcinogenic role, possibly through regulation of cell proliferation and differentiation, stimulation of apoptosis, immune modulation and regulation of estrogen receptor levels. Because breast cancer (BC) risk varies among ind ... Open Access Link to item Cite

Associations of novel variants in PIK3C3, INSR and MAP3K4 of the ATM pathway genes with pancreatic cancer risk.

Journal Article Am J Cancer Res · 2020 The ATM serine/threonine kinase (ATM) pathway plays important roles in pancreatic cancer (PanC) development and progression, but the roles of genetic variants of the genes in this pathway in the etiology of PanC are unknown. In the present study, we assess ... Open Access Link to item Cite

Novel genetic variants of SYK and ITGA1 related lymphangiogenesis signaling pathway predict non-small cell lung cancer survival.

Journal Article Am J Cancer Res · 2020 Although lymphangiogenesis is a vital step in lung cancer metastasis, the association between lymphangiogenesis and non-small cell lung cancer (NSCLC) survival remains unclear. Since single-nucleotide polymorphisms (SNPs) have been reported to predict NSCL ... Open Access Link to item Cite

Genetic variants of BIRC3 and NRG1 in the NLRP3 inflammasome pathway are associated with non-small cell lung cancer survival.

Journal Article Am J Cancer Res · 2020 The nod-like receptor protein 3 (NLRP3) is one of the most characterized inflammasomes, and its genetic variation and functional dysregulation are involved in pathogenesis of several cancers. To systematically evaluate the role of NLRP3 in predicting outco ... Open Access Link to item Cite

Novel genetic variants of PIP5K1C and MVB12B of the endosome-related pathway predict cutaneous melanoma-specific survival.

Journal Article Am J Cancer Res · 2020 Endosomes regulate cell polarity, adhesion, signaling, immunity, and tumor progression, which may influence cancer outcomes. Here we evaluated associations between 36,068 genetic variants of 228 endosome-related pathway genes and cutaneous melanoma disease ... Open Access Link to item Cite

Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures.

Journal Article Eur Respir J · December 2019 BACKGROUND: As an increasing number of patients exhibit concomitant cardiac and pulmonary disease, limitations of standard diagnostic criteria are more frequently encountered. Here, we apply noninvasive 129Xe magnetic resonance imaging (MRI) and spectrosco ... Full text Open Access Link to item Cite

Genetic variants in ELOVL2 and HSD17B12 predict melanoma-specific survival.

Journal Article Int J Cancer · November 15, 2019 Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively assessed associations of 14,522 comm ... Full text Open Access Link to item Cite

Longitudinal associations between BMI change and the risks of colorectal cancer incidence, cancer-relate and all-cause mortality among 81,388 older adults : BMI change and the risks of colorectal cancer incidence and mortality.

Journal Article BMC Cancer · November 11, 2019 BACKGROUND: It remains controversial whether weight change could influence the risks of colorectal cancer (CRC) and mortality. This study aimed to quantify the associations between full-spectrum changes in body mass index (BMI) and the risks of colorectal ... Full text Open Access Link to item Cite

Dynamic prediction of Alzheimer's disease progression using features of multiple longitudinal outcomes and time-to-event data.

Journal Article Stat Med · October 30, 2019 This paper is motivated by combining serial neurocognitive assessments and other clinical variables for monitoring the progression of Alzheimer's disease (AD). We propose a novel framework for the use of multiple longitudinal neurocognitive markers to pred ... Full text Open Access Link to item Cite

Successful use of the Unified Dyskinesia Rating Scale regardless of PD- or dyskinesia-duration.

Journal Article Parkinsonism Relat Disord · October 2019 OBJECTIVE: We assessed differential item functioning (DIF) in the Unified Dyskinesia Rating Scale (UDysRS) to evaluate bias risk from the duration of Parkinson's Disease (PD) and duration of dyskinesia. BACKGROUND: Assessing DIF is a core validation step f ... Full text Open Access Link to item Cite

Genetic variants of genes in the NER pathway associated with risk of breast cancer: A large-scale analysis of 14 published GWAS datasets in the DRIVE study.

Journal Article Int J Cancer · September 1, 2019 A recent hypothesis-free pathway-level analysis of genome-wide association study (GWAS) datasets suggested that the overall genetic variation measured by single nucleotide polymorphisms (SNPs) in the nucleotide excision repair (NER) pathway genes was assoc ... Full text Open Access Link to item Cite

Outcomes of Lymph Node Dissection for Non-metastatic Pancreatic Neuroendocrine Tumors: A Propensity Score-Weighted Analysis of the National Cancer Database.

Journal Article Ann Surg Oncol · September 2019 BACKGROUND: Although the National Comprehensive Cancer Network (NCCN) guidelines recommend use of lymph node dissection (LND) in patients with pancreatic neuroendocrine tumors (pNETs) > 2 cm, there is limited evidence to support the association between use ... Full text Open Access Link to item Cite

Cross-sectional CT Assessment of the Extent of Injectate Spread at CT Fluoroscopy-guided Cervical Epidural Interlaminar Steroid Injections.

Journal Article Radiology · September 2019 Background Previous studies analyzed contrast agent spread during cervical interlaminar epidural steroid injections (CILESIs) by using planar fluoroscopy and reported wide variance of the rate of spread to the ventral epidural space (VES). Cross-sectional ... Full text Open Access Link to item Cite

Bayesian quantile regression joint models: Inference and dynamic predictions.

Journal Article Stat Methods Med Res · August 2019 In the traditional joint models of a longitudinal and time-to-event outcome, a linear mixed model assuming normal random errors is used to model the longitudinal process. However, in many circumstances, the normality assumption is violated and the linear m ... Full text Open Access Link to item Cite

Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients.

Journal Article Int J Cancer · August 1, 2019 Abnormal methionine dependence in cancer cells has led to methionine restriction as a potential therapeutic strategy. We hypothesized that genetic variants involved in methionine-metabolic genes are associated with survival in nonsmall cell lung cancer (NS ... Full text Open Access Link to item Cite

Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.

Journal Article Mol Carcinog · August 2019 The liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) pathway has been identified as a new target for cancer therapy, because it controls the glucose and lipid metabolism in response to alterations in nutrients and intracellular energy levels. In th ... Full text Open Access Link to item Cite

A Bayesian approach for individual-level drug benefit-risk assessment.

Journal Article Stat Med · July 20, 2019 In existing benefit-risk assessment (BRA) methods, benefit and risk criteria are usually identified and defined separately based on aggregated clinical data and therefore ignore the individual-level differences as well as the association among the criteria ... Full text Open Access Link to item Cite

Potentially functional genetic variants in the TNF/TNFR signaling pathway genes predict survival of patients with non-small cell lung cancer in the PLCO cancer screening trial.

Journal Article Mol Carcinog · July 2019 The tumor necrosis factor (TNF)/TNF receptor (TNFR) pathway is known to influence survival of patients with cancer. We hypothesize that single nucleotide polymorphisms (SNPs) in the TNF/TNFR pathway genes related to apoptosis are associated with survival o ... Full text Open Access Link to item Cite

Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk.

Journal Article Cancer Sci · June 2019 Pancreatic cancer (PanC) is one of the most lethal solid malignancies, and metastatic PanC is often present at the time of diagnosis. Although several high- and low-penetrance genes have been implicated in PanC, their roles in carcinogenesis remain only pa ... Full text Open Access Link to item Cite

Potentially functional genetic variants in the complement-related immunity gene-set are associated with non-small cell lung cancer survival.

Journal Article Int J Cancer · April 15, 2019 The complement system plays an important role in the innate and adaptive immunity, complement components mediate tumor cytolysis of antibody-based immunotherapy, and complement activation in the tumor microenvironment may promote tumor progression or inhib ... Full text Open Access Link to item Cite

Dynamic predictions in Bayesian functional joint models for longitudinal and time-to-event data: An application to Alzheimer's disease.

Journal Article Stat Methods Med Res · February 2019 In the study of Alzheimer's disease, researchers often collect repeated measurements of clinical variables, event history, and functional data. If the health measurements deteriorate rapidly, patients may reach a level of cognitive impairment and are diagn ... Full text Open Access Link to item Cite

Bayesian Functional Joint Models for Multivariate Longitudinal and Time-to-Event Data.

Journal Article Comput Stat Data Anal · January 2019 A multivariate functional joint model framework is proposed which enables the repeatedly measured functional outcomes, scalar outcomes, and survival process to be modeled simultaneously while accounting for association among the multiple (functional and sc ... Full text Open Access Link to item Cite

Joint modeling of multiple repeated measures and survival data using multidimensional latent trait linear mixed model.

Journal Article Stat Methods Med Res · 2019 Impairment caused by Amyotrophic lateral sclerosis (ALS) is multidimensional (e.g. bulbar, fine motor, gross motor) and progressive. Its multidimensional nature precludes a single outcome to measure disease progression. Clinical trials of ALS use multiple ... Full text Open Access Link to item Cite

Predicting the Risk of Huntington's Disease with Multiple Longitudinal Biomarkers.

Journal Article J Huntingtons Dis · 2019 BACKGROUND: Huntington's disease (HD) has gradually become a public health threat, and there is a growing interest in developing prognostic models to predict the time for HD diagnosis. OBJECTIVE: This study aims to develop a novel prognostic model that lev ... Full text Open Access Link to item Cite

Developing and Validating Risk Assessment Models of Clinical Outcomes in Modern Oncology.

Journal Article JCO Precis Oncol · 2019 The identification of prognostic factors and building of risk assessment prognostic models will continue to play a major role in 21st century medicine in patient management and decision making. Investigators are often interested in examining the relationsh ... Full text Open Access Link to item Cite

A prognostic model of Alzheimer's disease relying on multiple longitudinal measures and time-to-event data.

Journal Article Alzheimers Dement · May 2018 INTRODUCTION: Characterizing progression in Alzheimer's disease is critically important for early detection and targeted treatment. The objective was to develop a prognostic model, based on multivariate longitudinal markers, for predicting progression-free ... Full text Open Access Link to item Cite

Joint modeling of longitudinal zero-inflated count and time-to-event data: A Bayesian perspective.

Journal Article Stat Methods Med Res · April 2018 Longitudinal zero-inflated count data are encountered frequently in substance-use research when assessing the effects of covariates and risk factors on outcomes. Often, both the time to a terminal event such as death or dropout and repeated measure count r ... Full text Open Access Link to item Cite

Periodic benefit-risk assessment using Bayesian stochastic multi-criteria acceptability analysis.

Journal Article Contemp Clin Trials · April 2018 Benefit-risk (BR) assessment is essential to ensure the best decisions are made for a medical product in the clinical development process, regulatory marketing authorization, post-market surveillance, and coverage and reimbursement decisions. One challenge ... Full text Open Access Link to item Cite

Relationship between Homocysteine and Muscle Strength Decline: The Baltimore Longitudinal Study of Aging.

Journal Article J Gerontol A Biol Sci Med Sci · March 14, 2018 BACKGROUND: Decreased muscle strength is strongly associated with future mobility limitations in older adults. Homocysteine is a risk factor for vascular disease and may exacerbate muscle strength decline. The present study aimed to examine the association ... Full text Open Access Link to item Cite

Bayesian regression model for recurrent event data with event-varying covariate effects and event effect.

Journal Article J Appl Stat · 2018 In the course of hypertension, cardiovascular disease events (e.g., stroke, heart failure) occur frequently and recurrently. The scientific interest in such study may lie in the estimation of treatment effect while accounting for the correlation among even ... Full text Open Access Link to item Cite

Missing Data in the Unified Dysksinesia Rating Scale (UDysRS).

Journal Article Mov Disord Clin Pract · 2018 OBJECTIVE: Identify the number of allowable missing values still permitting valid surrogate score calculation for the Unified Dyskinesia Rating Scale (UDysRS). BACKGROUND: Missing data frequently occur in Parkinson's disease rating scales, and they comprom ... Full text Open Access Link to item Cite

Pulmonary Catherization Data Correlate Poorly with Renal Function in Heart Failure.

Journal Article Cardiorenal Med · 2018 BACKGROUND: The mechanisms of renal dysfunction in heart failure are poorly understood. We chose to explore the relationship of cardiac filling pressures and cardiac index (CI) in relation to renal dysfunction in advanced heart failure. OBJECTIVES: To dete ... Full text Open Access Link to item Cite

Bayesian analysis of multi-type recurrent events and dependent termination with nonparametric covariate functions.

Journal Article Stat Methods Med Res · December 2017 Multi-type recurrent event data occur frequently in longitudinal studies. Dependent termination may occur when the terminal time is correlated to recurrent event times. In this article, we simultaneously model the multi-type recurrent events and a dependen ... Full text Open Access Link to item Cite

Dynamic Prediction of Renal Failure Using Longitudinal Biomarkers in a Cohort Study of Chronic Kidney Disease.

Journal Article Stat Biosci · December 2017 In longitudinal studies, prognostic biomarkers are often measured longitudinally. It is of both scientific and clinical interest to predict the risk of clinical events, such as disease progression or death, using these longitudinal biomarkers as well as ot ... Full text Open Access Link to item Cite

Validation of the Hebrew version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale.

Journal Article Parkinsonism Relat Disord · December 2017 BACKGROUND: The Movement Disorders Society (MDS) published the English new Unified Parkinson's Disease Rating Scale (MDS-UPDRS) as the official benchmark scale for Parkinson's disease (PD) in 2008. We aimed to validate the Hebrew version of the MDS-UPDRS, ... Full text Open Access Link to item Cite

Association of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores.

Journal Article Neurology · October 24, 2017 OBJECTIVE: To explore the association between metabolic syndrome and the Unified Parkinson's Disease Rating Scale (UPDRS) scores and, secondarily, the Symbol Digit Modalities Test (SDMT). METHODS: This is a secondary analysis of data from 1,022 of 1,741 pa ... Full text Open Access Link to item Cite

Functional joint model for longitudinal and time-to-event data: an application to Alzheimer's disease.

Journal Article Stat Med · September 30, 2017 Functional data are increasingly collected in public health and medical studies to better understand many complex diseases. Besides the functional data, other clinical measures are often collected repeatedly. Investigating the association between these lon ... Full text Open Access Link to item Cite

Multidimensional latent trait linear mixed model: an application in clinical studies with multivariate longitudinal outcomes.

Journal Article Stat Med · September 10, 2017 Multilevel item response theory (MLIRT) models have been widely used to analyze the multivariate longitudinal data of mixed types (e.g., categorical and continuous) in clinical studies. The MLIRT models often have unidimensional assumption, that is, the mu ... Full text Open Access Link to item Cite

Differential item functioning in the Unified Dyskinesia Rating Scale (UDysRS).

Journal Article Mov Disord · August 2017 OBJECTIVE: Test if differential item functioning due to gender, age, race/ethnicity, or education impacts Unified Dyskinesia Rating Scale scores. BACKGROUND: Testing rating scales for differential item functioning is a core validation step. If differential ... Full text Open Access Link to item Cite

Systematic review of severity scales and screening instruments for tics: Critique and recommendations.

Journal Article Mov Disord · March 2017 BACKGROUND: Several clinician, informant, and self-report instruments for tics and associated phenomena have been developed that differ in construct, comprehensiveness, and ease of administration. OBJECTIVE: A Movement Disorders Society subcommittee aimed ... Full text Open Access Link to item Cite

Bayesian hierarchical joint modeling using skew-normal/independent distributions

Journal Article Communications in Statistics-Simulation and Computation · 2017 Open Access Cite

Cross-Cultural Differences of the Non-Motor Symptoms Studied by the Traditional Chinese Version of the International Parkinson and Movement Disorder Society- Unified Parkinson's Disease Rating Scale.

Journal Article Mov Disord Clin Pract · 2017 BACKGROUND: Given the importance of ethnic differences in the evaluation of various aspects of symptoms in patients with Parkinson's disease (PD), we present the formal procedure for completing the traditional Chinese translation of the International and P ... Full text Open Access Link to item Cite

Vitamin B12 and homocysteine associations with gait speed in older adults

Journal Article Journal of Nutrition, Health, and Aging · 2017 Open Access Cite

Regular Exercise, Quality of Life, and Mobility in Parkinson's Disease: A Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data.

Journal Article J Parkinsons Dis · 2017 BACKGROUND: Research-based exercise interventions improve health-related quality of life (HRQL) and mobility in people with Parkinson's disease (PD). OBJECTIVE: To examine whether exercise habits were associated with changes in HRQL and mobility over two y ... Full text Open Access Link to item Cite

Vitamin B12 and Homocysteine Associations with Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging.

Journal Article J Nutr Health Aging · 2017 OBJECTIVES: This study aimed to assess the independent associations of serum levels of vitamin B12 and plasma concentrations of homocysteine with gait speed decline. DESIGN, SETTING, PARTICIPANTS: This study utilized longitudinal analysis of participants 5 ... Full text Open Access Link to item Cite

Gender-, age-, and race/ethnicity-based differential item functioning analysis of the movement disorder society-sponsored revision of the Unified Parkinson's disease rating scale.

Journal Article Mov Disord · December 2016 OBJECTIVE: Assess MDS-UPDRS items for gender-, age-, and race/ethnicity-based differential item functioning. BACKGROUND: Assessing differential item functioning is a core rating scale validation step. For the MDS-UPDRS, differential item functioning occurs ... Full text Open Access Link to item Cite

A hidden Markov model approach to analyze longitudinal ternary outcomes when some observed states are possibly misclassified.

Journal Article Stat Med · April 30, 2016 Understanding the dynamic disease process is vital in early detection, diagnosis, and measuring progression. Continuous-time Markov chain (CTMC) methods have been used to estimate state-change intensities but challenges arise when stages are potentially mi ... Full text Open Access Link to item Cite

Binomial regression with a misclassified covariate and outcome

Journal Article Statistical Methods in Medical Research · 2016 Open Access Cite

Augmented Beta rectangular regression models: A Bayesian perspective.

Journal Article Biom J · January 2016 Mixed effects Beta regression models based on Beta distributions have been widely used to analyze longitudinal percentage or proportional data ranging between zero and one. However, Beta distributions are not flexible to extreme outliers or excessive event ... Full text Open Access Link to item Cite

Analysis of censored longitudinal data with skewness and a terminal event

Journal Article Communications in Statistics-Simulation and Computation · 2016 Open Access Cite

Weight loss advice and prospective weight change among overweight firefighters

Journal Article International Journal of Occupational and Environmental Health · 2016 Open Access Cite

Serum Lymphocyte-Associated Cytokine Concentrations Change More Rapidly over Time in Multiple System Atrophy Compared to Parkinson Disease.

Journal Article Neuroimmunomodulation · 2016 OBJECTIVE: Chronic inflammatory processes contribute to the eventual death of motor neurons and the development of symptoms in both idiopathic Parkinson disease (PD) and multiple system atrophy (MSA). Given the faster rate of progression and more severe sy ... Full text Open Access Link to item Cite

Rating Scales for Pain in Parkinson's Disease: Critique and Recommendations.

Journal Article Mov Disord Clin Pract · 2016 BACKGROUND: We aimed at critically appraising the clinimetric properties of existing pain scales or questionnaires and to give recommendations for their use in Parkinson's disease (PD). METHODS: Clinimetric properties of pain scales used in PD were systema ... Full text Open Access Link to item Cite

Impact of Depression on Progression of Impairment and Disability in Early Parkinson's Disease.

Journal Article Mov Disord Clin Pract · December 2015 BACKGROUND: Depression is one of the most common nonmotor symptoms associated with Parkinson's disease (PD), yet the impact of depression on progression of disease is unclear. OBJECTIVE: The aim of this study was to prospectively characterize the relations ... Full text Open Access Link to item Cite

Predictors of intensive care unit length of stay and intracranial pressure in severe traumatic brain injury.

Journal Article J Crit Care · December 2015 OBJECTIVE: The aim of this study was to explore the relationship of intracranial pressure (ICP) with intensive care unit (ICU) length of stay in a large cohort of severe traumatic brain injury patients and identify factors associating with prolonged ICU co ... Full text Open Access Link to item Cite

Weight Advice Associated With Male Firefighter Weight Perception and Behavior.

Journal Article Am J Prev Med · October 2015 INTRODUCTION: The high prevalence of overweight and obesity threatens the health and safety of the fire service. Healthcare professionals may play an important role in helping firefighters achieve a healthy weight by providing weight loss counseling to at- ... Full text Open Access Link to item Cite

Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial.

Journal Article Lancet Neurol · August 2015 BACKGROUND: A systematic assessment of potential disease-modifying compounds for Parkinson's disease concluded that pioglitazone could hold promise for the treatment of patients with this disease. We assessed the effect of pioglitazone on the progression o ... Full text Open Access Link to item Cite

Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.

Journal Article JAMA · February 10, 2015 IMPORTANCE: There are no treatments available to slow or prevent the progression of Parkinson disease, despite its global prevalence and significant health care burden. The National Institute of Neurological Disorders and Stroke Exploratory Trials in Parki ... Full text Open Access Link to item Cite

Simultaneous inference of a misclassified outcome and competing risks failure time data.

Journal Article J Appl Stat · 2015 Ipsilateral breast tumor relapse (IBTR) often occurs in breast cancer patients after their breast conservation therapy. The IBTR status' classification (true local recurrence versus new ipsilateral primary tumor) is subject to error and there is no widely- ... Full text Open Access Link to item Cite

Handling missing values in the MDS-UPDRS

Journal Article Movement Disorders · 2015 Open Access Cite

Bayesian hierarchical model for multiple repeated measures and survival data: an application to Parkinson's disease.

Journal Article Stat Med · October 30, 2014 Multilevel item response theory models have been increasingly used to analyze the multivariate longitudinal data of mixed types (e.g., continuous and categorical) in clinical studies. To address the possible correlation between multivariate longitudinal me ... Full text Open Access Link to item Cite

Independent Spanish Validation of the Unified Dyskinesia Rating Scale.

Journal Article Mov Disord Clin Pract · September 2014 The Unified Dyskinesia Rating Scale (UDysRS) assesses the severity and disability caused by dyskinesias in Parkinson's disease (PD). As part of the UDysRS development plan, the International Parkinson and Movement Disorder Society (MDS) established guideli ... Full text Open Access Link to item Cite

Official Japanese Version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale: validation against the original English version.

Journal Article Mov Disord Clin Pract · September 1, 2014 BACKGROUND: The Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease (PD) Rating Scale (UPDRS) (MDS-UPDRS) has been developed and is now available in English. Part of the overall program includes the establishment of offici ... Full text Open Access Link to item Cite

An Empirical Bayes Method for Multivariate Meta-analysis with an Application in Clinical Trials.

Journal Article Commun Stat Theory Methods · July 29, 2014 We propose an empirical Bayes method for evaluating overall and study-specific treatment effects in multivariate meta-analysis with binary outcome. Instead of modeling transformed proportions or risks via commonly used multivariate general or generalized l ... Full text Open Access Link to item Cite

Joint model for a diagnostic test without a gold standard in the presence of a dependent terminal event.

Journal Article Stat Med · July 10, 2014 Breast cancer patients after breast conservation therapy often develop ipsilateral breast tumor relapse (IBTR), whose classification (true local recurrence versus new ipsilateral primary tumor) is subject to error, and there is no available gold standard. ... Full text Open Access Link to item Cite

Measuring disease progression in early Parkinson disease: the National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience.

Journal Article JAMA Neurol · June 2014 IMPORTANCE: Optimizing assessments of rate of progression in Parkinson disease (PD) is important in designing clinical trials, especially of potential disease-modifying agents. OBJECTIVE: To examine the value of measures of impairment, disability, and qual ... Full text Open Access Link to item Cite

IPMDS-Sponsored Scale Translation Program: Process, Format, and Clinimetric Testing Plan for the MDS-UPDRS and UDysRS.

Journal Article Mov Disord Clin Pract · June 2014 We present the methodology and results of the clinimetric testing program for non-English translations of International Parkinson and Movement Disorder Society (MDS)-sponsored scales. The programs focus on the MDS revision of the UPDRS (MDS-UPDRS) and the ... Full text Open Access Link to item Cite

A Bayesian approach to joint analysis of multivariate longitudinal data and parametric accelerated failure time.

Journal Article Stat Med · February 20, 2014 Impairment caused by Parkinson's disease (PD) is multidimensional (e.g., sensoria, functions, and cognition) and progressive. Its multidimensional nature precludes a single outcome to measure disease progression. Clinical trials of PD use multiple categori ... Full text Open Access Link to item Cite

mmeta: An R Package for Multivariate Meta-Analysis.

Journal Article J Stat Softw · January 1, 2014 This paper describes the core features of the R package mmeta, whichimplements the exact posterior inference of odds ratio, relative risk, and risk difference given either a single 2 × 2 table or multiple 2 × 2 tables when the risks within the same study a ... Open Access Link to item Cite

Joint analysis of stochastic processes with application to smoking patterns and insomnia.

Journal Article Stat Med · December 20, 2013 This article proposes a joint modeling framework for longitudinal insomnia measurements and a stochastic smoking cessation process in the presence of a latent permanent quitting state (i.e., 'cure'). We use a generalized linear mixed-effects model and a st ... Full text Open Access Link to item Cite

A hybrid method in combining treatment effects from matched and unmatched studies.

Journal Article Stat Med · December 10, 2013 The most common data structures in the biomedical studies have been matched or unmatched designs. Data structures resulting from a hybrid of the two may create challenges for statistical inferences. The question may arise whether to use parametric or nonpa ... Full text Open Access Link to item Cite

Robust Bayesian inference for multivariate longitudinal data by using normal/independent distributions.

Journal Article Stat Med · September 30, 2013 Many randomized clinical trials collect multivariate longitudinal measurements in different scales, for example, binary, ordinal, and continuous. Multilevel item response models are used to evaluate the global treatment effects across multiple outcomes whi ... Full text Open Access Link to item Cite

Rankin scale as a potential measure of global disability in early Parkinson's disease.

Journal Article J Clin Neurosci · September 2013 We conducted an exploratory analysis of the utility of the modified Rankin Scale (mRS) as a global measure of disability in early Parkinson's diesase (PD) using the baseline data from a large cohort of PD patients enrolled in a longitudinal study of creati ... Full text Open Access Link to item Cite

Effects of Air Pollution on Asthma Hospitalization Rates in Different Age Groups in Metropolitan Cities of Korea.

Journal Article Air Qual Atmos Health · September 1, 2013 Many studies have shown associations between air pollution and asthma admissions in Korea, but have not reported whether these effects differ by age classification. The purpose of this study was to determine whether air pollution effects on asthmatic hospi ... Full text Open Access Link to item Cite

A Bayesian model for misclassified binary outcomes and correlated survival data with applications to breast cancer.

Journal Article Stat Med · June 15, 2013 Breast cancer patients may experience ipsilateral breast tumor relapse (IBTR) after breast conservation therapy. IBTR is classified as either true local recurrence or new ipsilateral primary tumor. The correct classification of IBTR status has significant ... Full text Open Access Link to item Cite

Bayesian inference on risk differences: an application to multivariate meta-analysis of adverse events in clinical trials.

Journal Article Stat Biopharm Res · May 1, 2013 Multivariate meta-analysis is useful in combining evidence from independent studies which involve several comparisons among groups based on a single outcome. For binary outcomes, the commonly used statistical models for multivariate meta-analysis are multi ... Full text Open Access Link to item Cite

Design innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1.

Journal Article Mov Disord · October 2012 Based on the preclinical data and the results of a phase II futility study, creatine was selected for an efficacy trial in Parkinson's disease (PD). We present the design rationale and a description of the study cohort at baseline. A randomized, multicente ... Full text Open Access Link to item Cite

Reply to K.J. Van Zee et al

Journal Article Journal of Clinical Oncology · September 1, 2012 Full text Open Access Cite

Evaluation of a breast cancer nomogram for predicting risk of ipsilateral breast tumor recurrences in patients with ductal carcinoma in situ after local excision.

Journal Article J Clin Oncol · February 20, 2012 PURPOSE: Prediction of patients at highest risk for ipsilateral breast tumor recurrence (IBTR) after local excision of ductal carcinoma in situ (DCIS) remains a clinical concern. The aim of our study was to evaluate a published nomogram from Memorial Sloan ... Full text Open Access Link to item Cite

Novel staging system for predicting disease-specific survival in patients with breast cancer treated with surgery as the first intervention: time to modify the current American Joint Committee on Cancer staging system.

Journal Article J Clin Oncol · December 10, 2011 PURPOSE: American Joint Committee on Cancer (AJCC) staging is used to determine breast cancer prognosis, yet patient survival within each stage shows wide variation. We hypothesized that differences in biology influence this variation and that addition of ... Full text Open Access Link to item Cite

Rejoinder

Journal Article Journal of the American Statistical Association · September 2011 Full text Open Access Cite

Classification of ipsilateral breast tumor recurrences after breast conservation therapy can predict patient prognosis and facilitate treatment planning.

Journal Article Ann Surg · March 2011 OBJECTIVE: To classify ipsilateral breast tumor recurrences (IBTR) as either new primary tumors (NP) or true local recurrence (TR). We utilized 2 different methods and compared sensitivities and specificities between them. Our goal was to determine whether ... Full text Open Access Link to item Cite

Population value decomposition, a framework for the analysis of image populations

Journal Article Journal of the American Statistical Association · 2011 Open Access Cite

Shrinkage estimation for robust and efficient screening of single-SNP association from case-control genome-wide association studies.

Journal Article Genet Epidemiol · December 2009 Population-based case-control design has become one of the most popular approaches for conducting genome-wide association scans for rare diseases like cancer. In this article, we propose a novel method for improving the power of the widely used single-sing ... Full text Open Access Link to item Cite

Analysis of Case-Control Association Studies: SNPs, Imputation and Haplotypes.

Journal Article Stat Sci · November 1, 2009 Although prospective logistic regression is the standard method of analysis for case-control data, it has been recently noted that in genetic epidemiologic studies one can use the "retrospective" likelihood to gain major power by incorporating various popu ... Full text Open Access Link to item Cite

Bayesian inference for smoking cessation with a latent cure state.

Journal Article Biometrics · September 2009 We present a Bayesian approach to modeling dynamic smoking addiction behavior processes when cure is not directly observed due to censoring. Subject-specific probabilities model the stochastic transitions among three behavioral states: smoking, transient q ... Full text Open Access Link to item Cite

Human epidermal growth factor receptor-2 and estrogen receptor expression, a demonstration project using the residual tissue repository of the Surveillance, Epidemiology, and End Results (SEER) program.

Journal Article Breast Cancer Res Treat · January 2009 BACKGROUND: In 2001, the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program established Residual Tissue Repositories (RTR) in the Hawaii, Iowa, and Los Angeles Tumor Registries to collect discarded tissue blocks from pat ... Full text Open Access Link to item Cite

Analysis of Smoking Cessation Patterns Using a Stochastic Mixed-Effects Model With a Latent Cured State.

Journal Article J Am Stat Assoc · September 1, 2008 We develop a mixed model to capture the complex stochastic nature of tobacco abuse and dependence. This model describes transition processes among addiction and nonaddiction stages. An important innovation of our model is allowing an unobserved cure state, ... Full text Open Access Link to item Cite