Ralph Randal Bollinger

Journal Article Microbes Infect · March 2018 For thousands of years, changes in human cultures have altered the biota associated with the human body, and those alterations have strongly influenced human health. The hygiene hypothesis has evolved over the past 30 years into a nuanced biota alteration ... Full text Link to item Cite

Appendectomy and Clostridium difficile colitis: relationships revealed by clinical observations and immunology.

Journal Article World J Gastroenterol · September 14, 2013 Advances in understanding the interaction between the human immune system and the microbiome have led to an improved understanding of the function of the vermiform appendix as a safe-house for beneficial bacteria in the colon. These advances have been made ... Full text Link to item Cite

Incorporation of secretory immunoglobulin A into biofilms can decrease their resistance to ciprofloxacin.

Journal Article Microbiol Immunol · March 2011 Extracellular matrices utilized by biofilms growing on inert surfaces are generally produced entirely by the bacteria growing within those biofilms, whereas symbiotic (mutualistic) biofilms growing in or on a wide range of plants and animals utilize host-d ... Full text Link to item Cite

Adaptation in a mouse colony monoassociated with Escherichia coli K-12 for more than 1,000 days.

Journal Article Appl Environ Microbiol · July 2010 Although mice associated with a single bacterial species have been used to provide a simple model for analysis of host-bacteria relationships, bacteria have been shown to display adaptability when grown in a variety of novel environments. In this study, ch ... Full text Link to item Cite

Altering and assessing persistence of genetically modified E. coli MG1655 in the large bowel.

Journal Article Exp Biol Med (Maywood) · October 2009 One of the primary factors limiting the efficacy of probiotic therapies is short persistence time. Utilizing a novel method for assessment of persistence in the large bowel independent of survival of the organisms in the upper GI tract, we tested whether o ... Full text Link to item Cite

Comparative anatomy and phylogenetic distribution of the mammalian cecal appendix.

Journal Article J Evol Biol · October 2009 A recently improved understanding of gut immunity has merged with current thinking in biological and medical science, pointing to an apparent function of the mammalian cecal appendix as a safe-house for symbiotic gut microbes, preserving the flora during t ... Full text Link to item Cite

Surgery: Basic science and clinical evidence: Second edition

Book · December 1, 2008 "The ambitious undertaking of creating an evidence-based textbook of surgery has largely succeeded and I heartily recommend it. Surgery: Basic Science and Clinical Evidence have something for everyone, from the newest surgical resident to the established s ... Full text Cite

Vascular access for dialysis, chemotherapy, and nutritional support

Chapter · December 1, 2008 The success of many modern medical therapies is intimately tied to the success of vascular access. Hemodialysis for renal failure, chemotherapy for cancer, hyperalimentation for nutritional support, plasmapheresis for autoimmune disease, central pressure m ... Full text Cite

Preface

Book · December 1, 2008 Full text Cite

Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity.

Journal Article Exp Biol Med (Maywood) · October 2008 Gastroesophageal reflux has become a major health concern in industrialized countries, with drugs aimed at blocking acid production being more frequently prescribed than any other drug. Damage to lung tissue as a result of chronic aspiration of gastric flu ... Full text Link to item Cite

Biofilms in the large bowel suggest an apparent function of the human vermiform appendix.

Journal Article J Theor Biol · December 21, 2007 The human vermiform ("worm-like") appendix is a 5-10cm long and 0.5-1cm wide pouch that extends from the cecum of the large bowel. The architecture of the human appendix is unique among mammals, and few mammals other than humans have an appendix at all. Th ... Full text Link to item Cite

Biofilms in the normal human large bowel: fact rather than fiction.

Other Gut · October 2007 Link to item Cite

Discussions

Journal Article Annals of Surgery · May 1, 2006 Full text Cite

Secretory IgA and mucin-mediated biofilm formation by environmental strains of Escherichia coli: role of type 1 pili.

Journal Article Mol Immunol · February 2006 Recent studies suggest the importance of secretory IgA (SIgA) and mucin in the mediation of biofilm formation by commensal bacteria within the mammalian gut. Studies using a variety of strains of Escherichia coli have indicated that the interaction between ... Full text Link to item Cite

Organ allocation for transplantation in the USA and Korea: the changing roles of equity and utility.

Journal Article Yonsei Med J · December 31, 2004 Realizing the promise and managing the success of organ transplantation requires the creation of unique institutions. An Organ Procurement and Transplant Network (OPTN) must be capable of increasing the supply of cadaver donor organs, of allocating those o ... Full text Link to item Cite

Immune exclusion and immnune inclusion: A new model of host-bacterial interactions in the gut

Journal Article Clinical and Applied Immunology Reviews · July 1, 2004 It is thought that the primary function of secretory IgA (SIgA) is, in conjunction with the mucus lining of the gut, to prevent translocation of bacteria across the epithelial barrier. In this review, we evaluate the emerging idea that SIgA and the mucus o ... Full text Cite

Increased kidney transplantation utilizing expanded criteria deceased organ donors with results comparable to standard criteria donor transplant.

Journal Article Ann Surg · May 2004 OBJECTIVE: To compare outcomes in recipients of expanded criteria donor (ECD) versus standard criteria donor (SCD) kidneys at a single center using a standardized approach with similar immunosuppression. SUMMARY BACKGROUND DATA: Expanded criteria deceased ... Full text Link to item Cite

Immunoglobulin-mediated agglutination of and biofilm formation by Escherichia coli K-12 require the type 1 pilus fiber.

Journal Article Infect Immun · April 2004 The binding of human secretory immunoglobulin A (SIgA), the primary immunoglobulin in the gut, to Escherichia coli is thought to be dependent on type 1 pili. Type 1 pili are filamentous bacterial surface attachment organelles comprised principally of a sin ... Full text Link to item Cite

Microbial biofilms in the gut: visualization by electron microscopy and by acridine orange staining.

Journal Article Ultrastruct Pathol · 2004 The expression of colonization factors by gut bacteria, the growth rate of gut bacteria, and the rate of plasmid exchange by gut bacteria indicate that biofilms are a normal component of bacterial growth in the large bowel. Further, in vitro experiments de ... Link to item Cite

Optimization of operating room allocation using linear programming techniques.

Journal Article J Am Coll Surg · December 2003 BACKGROUND: New and innovative approaches must be used to rationally allocate scarce resources such as operating room time while simultaneously optimizing the associated financial return. In this article we use the technique of linear programming to optimi ... Full text Link to item Cite

Human secretory immunoglobulin A may contribute to biofilm formation in the gut.

Journal Article Immunology · August 2003 It is critical, both for the host and for the long-term benefit of the bacteria that colonize the gut, that bacterial overgrowth with subsequent bacterial translocation, which may lead to sepsis and death of the host, be avoided. Secretory IgA (sIgA) is kn ... Full text Link to item Cite

Unexpected anti-alpha GalNAc antibodies in alpha-galactosyl transferase-deficient mice: complex relationship between genotype and the natural antibody repertoire.

Journal Article Immunobiology · May 2001 Featured Publication Mice lacking the alpha-galactosyl transferase gene (GalT(-/-) mice) have been used extensively as a model for xenotransplantation. Unlike wild type (WT) mice, GalT(-/-) mice do not produce Gal alpha 1-3Gal and are known to produce natural IgM specific for ... Full text Link to item Cite

A prospective evaluation of health-related quality of life after ileal pouch anal anastomosis for ulcerative colitis.

Journal Article Am J Gastroenterol · May 2001 Featured Publication OBJECTIVES: The ileal pouch anal anastomosis is a safe and effective procedure but is also associated with pouchitis, small bowel obstruction, and incontinence. We prospectively evaluated the health-related quality of life using generic and disease-specifi ... Full text Link to item Cite

Organ procurement organization (OPO), best practices.

Journal Article Clin Transplant · 2001 Featured Publication There are currently 59 organ procurement organizations (OPOs) in the United States which serve their assigned geographic areas with variable productivity. Knowledge of organizational characteristics, programs and practices of more successful OPOs may be us ... Full text Link to item Cite

Natural anti-carbohydrate IgM in mice: dependence on age and strain.

Journal Article J Immunol Methods · December 1, 2000 Featured Publication Natural anti-carbohydrate antibodies in humans play a key role in natural immunity and in recognition of allogeneic and xenogeneic antigens. Presumably, natural anti-carbohydrate antibodies in mice have similar functions; but these antibodies have not been ... Full text Link to item Cite

The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants.

Journal Article J Clin Invest · April 15, 1998 Featured Publication Long-term success in xenotransplantation is currently hampered by acute vascular rejection. The inciting cause of acute vascular rejection is not yet known; however, a variety of observations suggest that the humoral immune response of the recipient agains ... Full text Link to item Cite

Health-related quality of life after ileoanal pull-through evaluation and assessment of new health status measures.

Journal Article Gastroenterology · July 1997 BACKGROUND & AIMS: Health-related quality of life (HRQL) after proctocolectomy is a critical parameter for management decisions in patients with chronic pancolitis. The aim of this study was to evaluate the HRQL of patients with ileoanal pull-through and t ... Full text Link to item Cite

Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts.

Journal Article Transplantation · March 27, 1997 A single bolus of soluble complement (C) receptor type 1 (sCR1, TP-10) has been shown to delay hyperacute rejection (HAR) of porcine cardiac xenografts (Xgs) by primate recipients. In these recipients, C activity slowly returned and C deposition was noted ... Full text Link to item Cite

Identification of poorly performing transplant centers using the UNOS center-specific data.

Journal Article Transplant Proc · 1997 Full text Link to item Cite

Orthostatic acute renal failure in a renal transplant.

Journal Article Transpl Int · 1997 Complications due to ureteric obstruction are an occasional cause for renal transplant dysfunction. Here we report an unusual case of orthostatic renal failure in a renal transplant recipient. Our patient had the previously reported predisposing risk facto ... Full text Link to item Cite

Renal transplantation in adults with thrombotic thrombocytopenic purpura/haemolytic-uraemic syndrome.

Journal Article Nephrol Dial Transplant · September 1996 BACKGROUND: Thrombotic thrombocytopenic purpura/haemolytic-uraemic syndrome (TTP/HUS) is a rare cause of renal failure in adults. There is little data concerning the outcome of adult patients who receive a renal transplant for TTP/HUS: METHODS: We have car ... Link to item Cite

The potential of xenotransplants.

Journal Article Transplant Proc · August 1996 Link to item Cite

Continuous complement (C) inhibition using soluble C receptor type 1 (sCR1): effect on hyperacute rejection (HAR) of pig-to-primate cardiac xenografts.

Journal Article Transplant Proc · April 1996 Link to item Cite

Immunoglobulin prevents complement-mediated hyperacute rejection in swine-to-primate xenotransplantation.

Journal Article J Clin Invest · November 1995 Immunoglobulins regulate the complement system by activating complement on foreign surfaces and diverting reactive complement proteins away from autologous cell surfaces. Based on this model, we explored the ability of Ig to balance complement activation v ... Full text Link to item Cite

Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis.

Journal Article Gastroenterology · September 1995 BACKGROUND & AIMS: Although clinical and pathological differences exist between Crohn's disease (CD) and ulcerative colitis (UC), distinguishing features are often absent, making diagnosis and treatment problematic. This study evaluated the differences in ... Full text Link to item Cite

Rapid, comprehensive analysis of human cytokine mRNA and its application to the study of acute renal allograft rejection.

Journal Article Hum Immunol · June 1995 Cytokine mRNA analysis was performed on human renal allograft needle core biopsies by a PCR-based assay. The assay was specifically developed to be capable of simultaneous analysis of multiple interleukin transcripts (IL-1-IL-12), as well as those of other ... Full text Link to item Cite

Recipient Kupffer cell influx into xenografted liver.

Journal Article Dig Dis Sci · March 1995 Previously we reported that the combination of total lymphoid irradiation (TLI), cyclosporine A (CsA), and splenectomy have an immunosuppressive effect sufficient to significantly prolong liver xenograft survival in the LVG hamster to the LEW rat model. Us ... Full text Link to item Cite

Immunopathology of porcine livers perfused with blood of humans with fulminant hepatic failure.

Journal Article Transplant Proc · February 1995 Link to item Cite

Prevention of hyperacute xenograft rejection by intravenous immunoglobulin.

Journal Article Transplant Proc · February 1995 Link to item Cite

A UNOS perspective on donor liver allocation. United Network for Organ Sharing.

Journal Article Liver Transpl Surg · January 1995 Full text Link to item Cite

Mechanisms of injury in porcine livers perfused with blood of patients with fulminant hepatic failure.

Journal Article Transplantation · December 15, 1994 Hyperacute rejection of renal and cardiac xenografts is initiated by the reaction of recipient natural antibodies and complement with endothelial cell antigens of the donor organ. The liver is thought to be less susceptible to this form of rejection; howev ... Link to item Cite

Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors.

Journal Article Neurosci Lett · September 12, 1994 Previous reports have described the ectopic expression of substance P binding sites on lymphoid aggregates and small blood vessels in inflammatory bowel disease. In this report, three non-peptide NK-1 receptor antagonists, CP-96,345, RP-67,580, and L-703,6 ... Full text Link to item Cite

Ganciclovir/acyclovir prophylaxis reduces the incidence of cytomegalovirus infections in pancreas transplant recipients.

Journal Article Transplant Proc · April 1994 Link to item Cite

The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts.

Journal Article Transplantation · February 1994 The use of xenografts (Xgs) from distantly related species to relieve the increasing shortage of organs for clinical transplantation is prevented by the occurrence of hyperacute rejection (HAR). This process, in which C activation plays a central role, can ... Full text Link to item Cite

United Network for Organ Sharing (UNOS)

Conference Journal of Transplant Coordination · December 1, 1993 Cite

Urological complications in 210 consecutive simultaneous pancreas-kidney transplants with bladder drainage.

Journal Article Ann Surg · October 1993 OBJECTIVE: The urological complications of 210 patients who underwent simultaneous pancreas-kidney (SPK) transplantation over a 7-year period were reviewed. SUMMARY BACKGROUND DATA: Worldwide, bladder drainage has become the accepted method of exocrine dra ... Full text Link to item Cite

Examination of the mechanisms responsible for tolerance induction after intrathymic inoculation of allogeneic bone marrow.

Journal Article Ann Surg · October 1993 OBJECTIVE: This study examined the immunologic mechanism(s) responsible for the induction of transplantation tolerance in rats pretreated with intrathymic inoculation of donor strain bone marrow. SUMMARY BACKGROUND DATA: Induction of unresponsiveness may i ... Full text Link to item Cite

Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4, tumor necrosis factor, and transforming growth factor-beta production.

Journal Article Ann Surg · October 1993 OBJECTIVE: These studies were designed to elucidate the mechanism by which signals delivered by anti-CD2 monoclonal antibody (MoAb) interfere with activational signals delivered by anti-CD3 MoAb and induce long-term graft survival and tolerance. SUMMARY BA ... Full text Link to item Cite

Adenine nucleotides of ischemic intestine do not reflect injury.

Journal Article J Surg Res · October 1993 Warm ischemia of the intestine is a medical emergency which results from mesenteric vascular occlusion. In addition, intestinal transplantation techniques will also inevitably result in intestinal ischemia. The recovery of organ function following ischemia ... Full text Link to item Cite

Brequinar sodium potentiates the effects of cyclosporine in experimental small bowel transplantation.

Journal Article Transplant Proc · June 1993 Link to item Cite

The human antiporcine cellular repertoire. In vitro studies of acquired and innate cellular responsiveness.

Journal Article Transplantation · April 1993 Discordant xenogeneic transplantation offers a potentially unlimited source of donor organs from easily bred, nonendangered, physiologically compatible animals, but has been limited by the inevitable occurrence of hyperacute rejection (HAR). The potential ... Link to item Cite

Human antiporcine mixed lymphocyte reaction.

Journal Article Transplant Proc · February 1993 Link to item Cite

Brequinar sodium potentiates the effects of cyclosporine in experimental small bowel transplantation

Journal Article Transplantation Proceedings · January 1, 1993 Cite

Human antiporcine mixed lymphocyte reaction

Journal Article Transplantation Proceedings · January 1, 1993 Cite

Pancreas transplantation for patients with diabetes mellitus. American Diabetes Association.

Journal Article Diabetes Care · November 1992 Full text Link to item Cite

Pancreas transplantation for patients with diabetes mellitus. American Diabetes Association.

Journal Article Diabetes Care · November 1992 Full text Link to item Cite

Intrathymic injection of donor alloantigens induces donor-specific vascularized allograft tolerance without immunosuppression.

Conference Ann Surg · October 1992 The induction of donor-specific tolerance could prevent the side effects of immunosuppression while improving allograft survival. Male adult Buffalo (RT1b) rats underwent an intrathymic (IT), portal venous (PV), intrasplenic (IS), or subcutaneous (SQ) inje ... Full text Link to item Cite

Rapamycin suppression of host-versus-graft and graft-versus-host disease in MHC-mismatched rats.

Journal Article Transplant Proc · June 1992 Link to item Cite

Use of tissue blood flow and high energy phosphate content to predict small bowel graft survival.

Journal Article Transplant Proc · June 1992 Link to item Cite