Scholars@Duke
Ralph Randal Bollinger

Ralph Randal Bollinger

Professor Emeritus of Surgery
Surgery
bolli001@mc.duke.edu
Box 2910 Med Ctr, Durham, NC 27710
113A Bell Bldg, Durham, NC 27710
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Selected Publications

Evolution of the hygiene hypothesis into biota alteration theory: what are the paradigms and where are the clinical applications?

Journal Article Microbes Infect · March 2018 For thousands of years, changes in human cultures have altered the biota associated with the human body, and those alterations have strongly influenced human health. The hygiene hypothesis has evolved over the past 30 years into a nuanced biota alteration ... Full text Link to item Cite

Appendectomy and Clostridium difficile colitis: relationships revealed by clinical observations and immunology.

Journal Article World J Gastroenterol · September 14, 2013 Advances in understanding the interaction between the human immune system and the microbiome have led to an improved understanding of the function of the vermiform appendix as a safe-house for beneficial bacteria in the colon. These advances have been made ... Full text Link to item Cite

Incorporation of secretory immunoglobulin A into biofilms can decrease their resistance to ciprofloxacin.

Journal Article Microbiol Immunol · March 2011 Extracellular matrices utilized by biofilms growing on inert surfaces are generally produced entirely by the bacteria growing within those biofilms, whereas symbiotic (mutualistic) biofilms growing in or on a wide range of plants and animals utilize host-d ... Full text Link to item Cite

Adaptation in a mouse colony monoassociated with Escherichia coli K-12 for more than 1,000 days.

Journal Article Appl Environ Microbiol · July 2010 Although mice associated with a single bacterial species have been used to provide a simple model for analysis of host-bacteria relationships, bacteria have been shown to display adaptability when grown in a variety of novel environments. In this study, ch ... Full text Link to item Cite

Altering and assessing persistence of genetically modified E. coli MG1655 in the large bowel.

Journal Article Exp Biol Med (Maywood) · October 2009 One of the primary factors limiting the efficacy of probiotic therapies is short persistence time. Utilizing a novel method for assessment of persistence in the large bowel independent of survival of the organisms in the upper GI tract, we tested whether o ... Full text Link to item Cite

Comparative anatomy and phylogenetic distribution of the mammalian cecal appendix.

Journal Article J Evol Biol · October 2009 A recently improved understanding of gut immunity has merged with current thinking in biological and medical science, pointing to an apparent function of the mammalian cecal appendix as a safe-house for symbiotic gut microbes, preserving the flora during t ... Full text Link to item Cite

Surgery: Basic science and clinical evidence: Second edition

Book · December 1, 2008 "The ambitious undertaking of creating an evidence-based textbook of surgery has largely succeeded and I heartily recommend it. Surgery: Basic Science and Clinical Evidence have something for everyone, from the newest surgical resident to the established s ... Full text Cite

Vascular access for dialysis, chemotherapy, and nutritional support

Chapter · December 1, 2008 The success of many modern medical therapies is intimately tied to the success of vascular access. Hemodialysis for renal failure, chemotherapy for cancer, hyperalimentation for nutritional support, plasmapheresis for autoimmune disease, central pressure m ... Full text Cite

Preface

Book · December 1, 2008 Full text Cite

Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity.

Journal Article Exp Biol Med (Maywood) · October 2008 Gastroesophageal reflux has become a major health concern in industrialized countries, with drugs aimed at blocking acid production being more frequently prescribed than any other drug. Damage to lung tissue as a result of chronic aspiration of gastric flu ... Full text Link to item Cite

Biofilms in the large bowel suggest an apparent function of the human vermiform appendix.

Journal Article J Theor Biol · December 21, 2007 The human vermiform ("worm-like") appendix is a 5-10cm long and 0.5-1cm wide pouch that extends from the cecum of the large bowel. The architecture of the human appendix is unique among mammals, and few mammals other than humans have an appendix at all. Th ... Full text Link to item Cite

Discussions

Journal Article Annals of Surgery · May 1, 2006 Full text Cite

Secretory IgA and mucin-mediated biofilm formation by environmental strains of Escherichia coli: role of type 1 pili.

Journal Article Mol Immunol · February 2006 Recent studies suggest the importance of secretory IgA (SIgA) and mucin in the mediation of biofilm formation by commensal bacteria within the mammalian gut. Studies using a variety of strains of Escherichia coli have indicated that the interaction between ... Full text Link to item Cite

Organ allocation for transplantation in the USA and Korea: the changing roles of equity and utility.

Journal Article Yonsei Med J · December 31, 2004 Realizing the promise and managing the success of organ transplantation requires the creation of unique institutions. An Organ Procurement and Transplant Network (OPTN) must be capable of increasing the supply of cadaver donor organs, of allocating those o ... Full text Link to item Cite

Immune exclusion and immnune inclusion: A new model of host-bacterial interactions in the gut

Journal Article Clinical and Applied Immunology Reviews · July 1, 2004 It is thought that the primary function of secretory IgA (SIgA) is, in conjunction with the mucus lining of the gut, to prevent translocation of bacteria across the epithelial barrier. In this review, we evaluate the emerging idea that SIgA and the mucus o ... Full text Cite

Increased kidney transplantation utilizing expanded criteria deceased organ donors with results comparable to standard criteria donor transplant.

Journal Article Ann Surg · May 2004 OBJECTIVE: To compare outcomes in recipients of expanded criteria donor (ECD) versus standard criteria donor (SCD) kidneys at a single center using a standardized approach with similar immunosuppression. SUMMARY BACKGROUND DATA: Expanded criteria deceased ... Full text Link to item Cite

Immunoglobulin-mediated agglutination of and biofilm formation by Escherichia coli K-12 require the type 1 pilus fiber.

Journal Article Infect Immun · April 2004 The binding of human secretory immunoglobulin A (SIgA), the primary immunoglobulin in the gut, to Escherichia coli is thought to be dependent on type 1 pili. Type 1 pili are filamentous bacterial surface attachment organelles comprised principally of a sin ... Full text Link to item Cite

Microbial biofilms in the gut: visualization by electron microscopy and by acridine orange staining.

Journal Article Ultrastruct Pathol · 2004 The expression of colonization factors by gut bacteria, the growth rate of gut bacteria, and the rate of plasmid exchange by gut bacteria indicate that biofilms are a normal component of bacterial growth in the large bowel. Further, in vitro experiments de ... Link to item Cite

Optimization of operating room allocation using linear programming techniques.

Journal Article J Am Coll Surg · December 2003 BACKGROUND: New and innovative approaches must be used to rationally allocate scarce resources such as operating room time while simultaneously optimizing the associated financial return. In this article we use the technique of linear programming to optimi ... Full text Link to item Cite

Evolution of the hygiene hypothesis into biota alteration theory: what are the paradigms and where are the clinical applications?

Journal Article Microbes Infect · March 2018 For thousands of years, changes in human cultures have altered the biota associated with the human body, and those alterations have strongly influenced human health. The hygiene hypothesis has evolved over the past 30 years into a nuanced biota alteration ... Full text Link to item Cite

Appendectomy and Clostridium difficile colitis: relationships revealed by clinical observations and immunology.

Journal Article World J Gastroenterol · September 14, 2013 Advances in understanding the interaction between the human immune system and the microbiome have led to an improved understanding of the function of the vermiform appendix as a safe-house for beneficial bacteria in the colon. These advances have been made ... Full text Link to item Cite

Incorporation of secretory immunoglobulin A into biofilms can decrease their resistance to ciprofloxacin.

Journal Article Microbiol Immunol · March 2011 Extracellular matrices utilized by biofilms growing on inert surfaces are generally produced entirely by the bacteria growing within those biofilms, whereas symbiotic (mutualistic) biofilms growing in or on a wide range of plants and animals utilize host-d ... Full text Link to item Cite

Adaptation in a mouse colony monoassociated with Escherichia coli K-12 for more than 1,000 days.

Journal Article Appl Environ Microbiol · July 2010 Although mice associated with a single bacterial species have been used to provide a simple model for analysis of host-bacteria relationships, bacteria have been shown to display adaptability when grown in a variety of novel environments. In this study, ch ... Full text Link to item Cite

Altering and assessing persistence of genetically modified E. coli MG1655 in the large bowel.

Journal Article Exp Biol Med (Maywood) · October 2009 One of the primary factors limiting the efficacy of probiotic therapies is short persistence time. Utilizing a novel method for assessment of persistence in the large bowel independent of survival of the organisms in the upper GI tract, we tested whether o ... Full text Link to item Cite

Comparative anatomy and phylogenetic distribution of the mammalian cecal appendix.

Journal Article J Evol Biol · October 2009 A recently improved understanding of gut immunity has merged with current thinking in biological and medical science, pointing to an apparent function of the mammalian cecal appendix as a safe-house for symbiotic gut microbes, preserving the flora during t ... Full text Link to item Cite

Surgery: Basic science and clinical evidence: Second edition

Book · December 1, 2008 "The ambitious undertaking of creating an evidence-based textbook of surgery has largely succeeded and I heartily recommend it. Surgery: Basic Science and Clinical Evidence have something for everyone, from the newest surgical resident to the established s ... Full text Cite

Vascular access for dialysis, chemotherapy, and nutritional support

Chapter · December 1, 2008 The success of many modern medical therapies is intimately tied to the success of vascular access. Hemodialysis for renal failure, chemotherapy for cancer, hyperalimentation for nutritional support, plasmapheresis for autoimmune disease, central pressure m ... Full text Cite

Preface

Book · December 1, 2008 Full text Cite

Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity.

Journal Article Exp Biol Med (Maywood) · October 2008 Gastroesophageal reflux has become a major health concern in industrialized countries, with drugs aimed at blocking acid production being more frequently prescribed than any other drug. Damage to lung tissue as a result of chronic aspiration of gastric flu ... Full text Link to item Cite

Biofilms in the large bowel suggest an apparent function of the human vermiform appendix.

Journal Article J Theor Biol · December 21, 2007 The human vermiform ("worm-like") appendix is a 5-10cm long and 0.5-1cm wide pouch that extends from the cecum of the large bowel. The architecture of the human appendix is unique among mammals, and few mammals other than humans have an appendix at all. Th ... Full text Link to item Cite

Discussions

Journal Article Annals of Surgery · May 1, 2006 Full text Cite

Secretory IgA and mucin-mediated biofilm formation by environmental strains of Escherichia coli: role of type 1 pili.

Journal Article Mol Immunol · February 2006 Recent studies suggest the importance of secretory IgA (SIgA) and mucin in the mediation of biofilm formation by commensal bacteria within the mammalian gut. Studies using a variety of strains of Escherichia coli have indicated that the interaction between ... Full text Link to item Cite

Organ allocation for transplantation in the USA and Korea: the changing roles of equity and utility.

Journal Article Yonsei Med J · December 31, 2004 Realizing the promise and managing the success of organ transplantation requires the creation of unique institutions. An Organ Procurement and Transplant Network (OPTN) must be capable of increasing the supply of cadaver donor organs, of allocating those o ... Full text Link to item Cite

Immune exclusion and immnune inclusion: A new model of host-bacterial interactions in the gut

Journal Article Clinical and Applied Immunology Reviews · July 1, 2004 It is thought that the primary function of secretory IgA (SIgA) is, in conjunction with the mucus lining of the gut, to prevent translocation of bacteria across the epithelial barrier. In this review, we evaluate the emerging idea that SIgA and the mucus o ... Full text Cite

Increased kidney transplantation utilizing expanded criteria deceased organ donors with results comparable to standard criteria donor transplant.

Journal Article Ann Surg · May 2004 OBJECTIVE: To compare outcomes in recipients of expanded criteria donor (ECD) versus standard criteria donor (SCD) kidneys at a single center using a standardized approach with similar immunosuppression. SUMMARY BACKGROUND DATA: Expanded criteria deceased ... Full text Link to item Cite

Immunoglobulin-mediated agglutination of and biofilm formation by Escherichia coli K-12 require the type 1 pilus fiber.

Journal Article Infect Immun · April 2004 The binding of human secretory immunoglobulin A (SIgA), the primary immunoglobulin in the gut, to Escherichia coli is thought to be dependent on type 1 pili. Type 1 pili are filamentous bacterial surface attachment organelles comprised principally of a sin ... Full text Link to item Cite

Microbial biofilms in the gut: visualization by electron microscopy and by acridine orange staining.

Journal Article Ultrastruct Pathol · 2004 The expression of colonization factors by gut bacteria, the growth rate of gut bacteria, and the rate of plasmid exchange by gut bacteria indicate that biofilms are a normal component of bacterial growth in the large bowel. Further, in vitro experiments de ... Link to item Cite

Optimization of operating room allocation using linear programming techniques.

Journal Article J Am Coll Surg · December 2003 BACKGROUND: New and innovative approaches must be used to rationally allocate scarce resources such as operating room time while simultaneously optimizing the associated financial return. In this article we use the technique of linear programming to optimi ... Full text Link to item Cite

Human secretory immunoglobulin A may contribute to biofilm formation in the gut.

Journal Article Immunology · August 2003 It is critical, both for the host and for the long-term benefit of the bacteria that colonize the gut, that bacterial overgrowth with subsequent bacterial translocation, which may lead to sepsis and death of the host, be avoided. Secretory IgA (sIgA) is kn ... Full text Link to item Cite

Unexpected anti-alpha GalNAc antibodies in alpha-galactosyl transferase-deficient mice: complex relationship between genotype and the natural antibody repertoire.

Journal Article Immunobiology · May 2001 Featured Publication Mice lacking the alpha-galactosyl transferase gene (GalT(-/-) mice) have been used extensively as a model for xenotransplantation. Unlike wild type (WT) mice, GalT(-/-) mice do not produce Gal alpha 1-3Gal and are known to produce natural IgM specific for ... Full text Link to item Cite

A prospective evaluation of health-related quality of life after ileal pouch anal anastomosis for ulcerative colitis.

Journal Article Am J Gastroenterol · May 2001 Featured Publication OBJECTIVES: The ileal pouch anal anastomosis is a safe and effective procedure but is also associated with pouchitis, small bowel obstruction, and incontinence. We prospectively evaluated the health-related quality of life using generic and disease-specifi ... Full text Link to item Cite

Organ procurement organization (OPO), best practices.

Journal Article Clin Transplant · 2001 Featured Publication There are currently 59 organ procurement organizations (OPOs) in the United States which serve their assigned geographic areas with variable productivity. Knowledge of organizational characteristics, programs and practices of more successful OPOs may be us ... Full text Link to item Cite

Natural anti-carbohydrate IgM in mice: dependence on age and strain.

Journal Article J Immunol Methods · December 1, 2000 Featured Publication Natural anti-carbohydrate antibodies in humans play a key role in natural immunity and in recognition of allogeneic and xenogeneic antigens. Presumably, natural anti-carbohydrate antibodies in mice have similar functions; but these antibodies have not been ... Full text Link to item Cite

The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants.

Journal Article J Clin Invest · April 15, 1998 Featured Publication Long-term success in xenotransplantation is currently hampered by acute vascular rejection. The inciting cause of acute vascular rejection is not yet known; however, a variety of observations suggest that the humoral immune response of the recipient agains ... Full text Link to item Cite

Health-related quality of life after ileoanal pull-through evaluation and assessment of new health status measures.

Journal Article Gastroenterology · July 1997 BACKGROUND & AIMS: Health-related quality of life (HRQL) after proctocolectomy is a critical parameter for management decisions in patients with chronic pancolitis. The aim of this study was to evaluate the HRQL of patients with ileoanal pull-through and t ... Full text Link to item Cite

Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts.

Journal Article Transplantation · March 27, 1997 A single bolus of soluble complement (C) receptor type 1 (sCR1, TP-10) has been shown to delay hyperacute rejection (HAR) of porcine cardiac xenografts (Xgs) by primate recipients. In these recipients, C activity slowly returned and C deposition was noted ... Full text Link to item Cite

Orthostatic acute renal failure in a renal transplant.

Journal Article Transpl Int · 1997 Complications due to ureteric obstruction are an occasional cause for renal transplant dysfunction. Here we report an unusual case of orthostatic renal failure in a renal transplant recipient. Our patient had the previously reported predisposing risk facto ... Full text Link to item Cite

Renal transplantation in adults with thrombotic thrombocytopenic purpura/haemolytic-uraemic syndrome.

Journal Article Nephrol Dial Transplant · September 1996 BACKGROUND: Thrombotic thrombocytopenic purpura/haemolytic-uraemic syndrome (TTP/HUS) is a rare cause of renal failure in adults. There is little data concerning the outcome of adult patients who receive a renal transplant for TTP/HUS: METHODS: We have car ... Link to item Cite

The potential of xenotransplants.

Journal Article Transplant Proc · August 1996 Link to item Cite

Immunoglobulin prevents complement-mediated hyperacute rejection in swine-to-primate xenotransplantation.

Journal Article J Clin Invest · November 1995 Immunoglobulins regulate the complement system by activating complement on foreign surfaces and diverting reactive complement proteins away from autologous cell surfaces. Based on this model, we explored the ability of Ig to balance complement activation v ... Full text Link to item Cite

Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis.

Journal Article Gastroenterology · September 1995 BACKGROUND & AIMS: Although clinical and pathological differences exist between Crohn's disease (CD) and ulcerative colitis (UC), distinguishing features are often absent, making diagnosis and treatment problematic. This study evaluated the differences in ... Full text Link to item Cite

Rapid, comprehensive analysis of human cytokine mRNA and its application to the study of acute renal allograft rejection.

Journal Article Hum Immunol · June 1995 Cytokine mRNA analysis was performed on human renal allograft needle core biopsies by a PCR-based assay. The assay was specifically developed to be capable of simultaneous analysis of multiple interleukin transcripts (IL-1-IL-12), as well as those of other ... Full text Link to item Cite

Recipient Kupffer cell influx into xenografted liver.

Journal Article Dig Dis Sci · March 1995 Previously we reported that the combination of total lymphoid irradiation (TLI), cyclosporine A (CsA), and splenectomy have an immunosuppressive effect sufficient to significantly prolong liver xenograft survival in the LVG hamster to the LEW rat model. Us ... Full text Link to item Cite

Mechanisms of injury in porcine livers perfused with blood of patients with fulminant hepatic failure.

Journal Article Transplantation · December 15, 1994 Hyperacute rejection of renal and cardiac xenografts is initiated by the reaction of recipient natural antibodies and complement with endothelial cell antigens of the donor organ. The liver is thought to be less susceptible to this form of rejection; howev ... Link to item Cite

Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors.

Journal Article Neurosci Lett · September 12, 1994 Previous reports have described the ectopic expression of substance P binding sites on lymphoid aggregates and small blood vessels in inflammatory bowel disease. In this report, three non-peptide NK-1 receptor antagonists, CP-96,345, RP-67,580, and L-703,6 ... Full text Link to item Cite

The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts.

Journal Article Transplantation · February 1994 The use of xenografts (Xgs) from distantly related species to relieve the increasing shortage of organs for clinical transplantation is prevented by the occurrence of hyperacute rejection (HAR). This process, in which C activation plays a central role, can ... Full text Link to item Cite

United Network for Organ Sharing (UNOS)

Conference Journal of Transplant Coordination · December 1, 1993 Cite

Urological complications in 210 consecutive simultaneous pancreas-kidney transplants with bladder drainage.

Journal Article Ann Surg · October 1993 OBJECTIVE: The urological complications of 210 patients who underwent simultaneous pancreas-kidney (SPK) transplantation over a 7-year period were reviewed. SUMMARY BACKGROUND DATA: Worldwide, bladder drainage has become the accepted method of exocrine dra ... Full text Link to item Cite

Examination of the mechanisms responsible for tolerance induction after intrathymic inoculation of allogeneic bone marrow.

Journal Article Ann Surg · October 1993 OBJECTIVE: This study examined the immunologic mechanism(s) responsible for the induction of transplantation tolerance in rats pretreated with intrathymic inoculation of donor strain bone marrow. SUMMARY BACKGROUND DATA: Induction of unresponsiveness may i ... Full text Link to item Cite

Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4, tumor necrosis factor, and transforming growth factor-beta production.

Journal Article Ann Surg · October 1993 OBJECTIVE: These studies were designed to elucidate the mechanism by which signals delivered by anti-CD2 monoclonal antibody (MoAb) interfere with activational signals delivered by anti-CD3 MoAb and induce long-term graft survival and tolerance. SUMMARY BA ... Full text Link to item Cite

Adenine nucleotides of ischemic intestine do not reflect injury.

Journal Article J Surg Res · October 1993 Warm ischemia of the intestine is a medical emergency which results from mesenteric vascular occlusion. In addition, intestinal transplantation techniques will also inevitably result in intestinal ischemia. The recovery of organ function following ischemia ... Full text Link to item Cite

The human antiporcine cellular repertoire. In vitro studies of acquired and innate cellular responsiveness.

Journal Article Transplantation · April 1993 Discordant xenogeneic transplantation offers a potentially unlimited source of donor organs from easily bred, nonendangered, physiologically compatible animals, but has been limited by the inevitable occurrence of hyperacute rejection (HAR). The potential ... Link to item Cite

Human antiporcine mixed lymphocyte reaction.

Journal Article Transplant Proc · February 1993 Link to item Cite

Human antiporcine mixed lymphocyte reaction

Journal Article Transplantation Proceedings · January 1, 1993 Cite

Intrathymic injection of donor alloantigens induces donor-specific vascularized allograft tolerance without immunosuppression.

Conference Ann Surg · October 1992 The induction of donor-specific tolerance could prevent the side effects of immunosuppression while improving allograft survival. Male adult Buffalo (RT1b) rats underwent an intrathymic (IT), portal venous (PV), intrasplenic (IS), or subcutaneous (SQ) inje ... Full text Link to item Cite

Use of heterohybridomas in xenotransplantation.

Journal Article Transplant Proc · April 1992 Link to item Cite

Species differences in natural xenoantibody to swine.

Journal Article Transplant Proc · April 1992 Link to item Cite

Renal allograft-infiltrating lymphocytes. A prospective analysis of in vitro growth characteristics and clinical relevance.

Journal Article Transplantation · February 1992 One-hundred consecutive human renal allograft Tru-cut needle biopsies were studied for in vitro proliferation of T lymphocytes under restrictive culture conditions containing low-dose recombinant interleukin 2. Each biopsy was entered into a blinded code a ... Full text Link to item Cite

Rapamycin

Journal Article Clinical Transplantation · December 1, 1991 Cite

Evaluation of solutions for small intestinal preservation. Biochemical changes as a function of storage time.

Journal Article Transplantation · November 1991 A number of organ preservation solutions have been formulated to slow the inevitable progression of ischemic injury, thus prolonging the storage time between removal and implantation. As adenine nucleotide content has been shown to correlate with the funct ... Full text Link to item Cite

Transport of free fatty acid and triglyceride in anhepatic rats.

Journal Article Hepatology · November 1991 Without a liver the fractional plasma removal of free fatty acid is one third and chylomicron triglyceride one half of that in the intact rat. The intestine of the anhepatic rat converted enteral fatty acid to plasma triglyceride but was unable to do the s ... Full text Link to item Cite

The effect of soluble complement receptor type 1 on hyperacute xenograft rejection.

Journal Article Transplantation · November 1991 In the guinea pig-to-rat model of hyperacute xenograft (Xg) rejection, the effect of complement inhibition using systemically administered soluble complement receptor type 1 (sCR1) on discordant cardiac Xg survival was investigated. In PBS-treated control ... Full text Link to item Cite

The effect of soluble complement receptor type 1 on hyperacute allograft rejection.

Journal Article J Surg Res · April 1991 A major obstacle to successful organ transplantation in sensitized recipients is antibody-mediated hyperacute rejection. We hypothesized that human recombinant soluble complement receptor type 1 (sCR1), which inhibits activation of the complement cascade a ... Full text Link to item Cite

Total lymphoid irradiation for cardiac xenotransplantation in nonhuman primates

Conference Transplantation Proceedings · January 1, 1991 Cite

Macrophage migration into hepatic xenografts in the hamster-to-rat combination

Conference Transplantation Proceedings · January 1, 1991 Cite

Rejection revisited

Journal Article Annals of Surgery · January 1, 1991 Full text Cite

The effect of 15-deoxyspergualin on hamster-to-rat cardiac xenograft survival

Journal Article Transplantation Proceedings · January 1, 1991 Cite

Suppression of hepatic allograft rejection in the rat by mitomycin C-treated donor splenocytes: analysis of the immune status.

Journal Article J Clin Lab Immunol · June 1990 A single intraperitoneal injection of 3 x 10(6) donor splenocytes treated with mitomycin c (MMC) seven days before hepatic transplantation prolongs survival of hepatic allografts in the ACI (RT1a) to LEW (RT1l) rat combination. This effect is donor specifi ... Link to item Cite

Irradiation for xenogeneic transplantation.

Journal Article Radiother Oncol · May 1990 Xenogeneic transplantation (XT) is the transplantation of organs or tissues from a member of one species to a member of another. Mammalian species frequently have circulating antibody which is directed against the foreign organ irrespective of known prior ... Full text Link to item Cite

Significant prolongation of hamster liver transplant survival in Lewis rats by total-lymphoid irradiation, cyclosporine, and splenectomy.

Journal Article Transplantation · January 1990 The effects of total lymphoid irradiation, cyclosporine and splenectomy alone and in combination have been studied in liver transplants from the LVG hamster to the LEW rat. Neither CsA alone, splenectomy alone, nor TLI alone prolonged graft survival. CsA/s ... Full text Link to item Cite

Renal transplantation in the American black.

Journal Article Transplant Proc · December 1989 Link to item Cite

Prevention of hemodialysis fistula thrombosis. Early detection of venous stenoses.

Journal Article Kidney Int · October 1989 Venous dialysis pressures were measured consecutively in 168 chronic hemodialysis patients for 265 patient-years of monitored dialysis. Venous dialysis pressure greater than 150 mm Hg measured by the protocol were considered elevated. Seventy-three patient ... Full text Link to item Cite

Prospective analysis of strategies for diagnosing renovascular hypertension.

Journal Article Hypertension · September 1989 Renovascular hypertension is a potentially curable form of high blood pressure. However, it is unclear how best to select patients who are likely to have renovascular hypertension, what diagnostic strategy to use in these selected patients, and how to pred ... Full text Link to item Cite

Percutaneous transhepatic ultrasonic cholelithotripsy.

Journal Article Arch Surg · June 1989 In a patient with acute cholecystitis whose body habitus precluded cholecystectomy, we used percutaneous transhepatic ultrasonic cholelithotripsy. We compare it with other modalities applicable in such cases. Although not commonly used, these alternatives ... Full text Link to item Cite

Intravenous digital subtraction renal angiography: use in screening for renovascular hypertension.

Journal Article Radiology · April 1989 Intravenous digital subtraction renal angiography (DSRA) has been compared with conventional angiography only in small, selected series of hypertensive patients. The authors prospectively examined with intravenous DSRA 94 patients at increased risk for ren ... Full text Link to item Cite

Variable allograft responses to pretreatment with donor splenocytes treated with mitomycin C in the rat.

Journal Article Transplantation · February 1989 In an attempt to investigate the nonspecificity of the effect of administration of donor splenocytes treated with mitomycin C (MMC) 7 days before transplantation in inducing immunological unresponsiveness, the survival rates of liver, heart, small bowel, a ... Full text Link to item Cite

A simplified single stage total hepatectomy in the rat with maintenance of gastrointestinal absorptive function.

Journal Article Hepatology · January 1989 A technique is described to remove the entire liver in a single stage with preservation of intestinal absorptive function. An inverted V-shape polyethylene cannula, either heparin bonded or silicon coated, was inserted into the portal vein and inferior ven ... Full text Link to item Cite

The role of class I major histocompatibility complex antigens in prolonging the survival of hepatic allografts in the rat.

Journal Article Transplantation · January 1989 In an attempt to study the role of class I major histocompatibility complex antigens in inducing immunological unresponsiveness, the survival rates of hepatic allografts were compared in rats pretreated with blood taken from various rat strains. A single i ... Full text Link to item Cite

New approaches to immunosuppression for xenotransplantation

Conference Xenograft 25: proceedings of the International Congress, Xenograft 25. ICS880 · January 1, 1989 Cite

Perforation of the gastrointestinal tract following renal transplantation

Journal Article Transplantation Proceedings · January 1, 1989 Cite

Surgical renal artery reconstruction after percutaneous transluminal angioplasty.

Journal Article J Vasc Surg · October 1988 Percutaneous transluminal renal angioplasty (PTRA) is a controversial treatment for renal artery stenosis. This article discusses whether or not a prior attempt at PTRA compromises a subsequent elective or emergent surgical revascularization. Thirteen pati ... Full text Link to item Cite

The role of irradiation in solid organ transplantation.

Journal Article Int J Radiat Oncol Biol Phys · October 1988 Full text Link to item Cite

Prospective evaluation of a Dacron cuffed hemodialysis catheter for prolonged use.

Journal Article Am J Kidney Dis · February 1988 Double lumen subclavian venous hemodialysis catheters are in wide use in the United States to provide temporary vascular access. The disadvantages of these catheters include a high infection rate and short use-life (2 to 3 weeks). We evaluated a felt cuffe ... Full text Link to item Cite

Prolonged survival of hepatic xenografts in the hamster to rat combination: Efficacy of cyclosporine in combination with splenectomy

Journal Article Transplantation Proceedings · January 1, 1988 Experiments were designed to test the ability of CsA in combination with splenectomy to prolong hepatic xenograft survival in the LVG hamster to LEW rat combination. Synergism could be predicted by the known effects of these modalities on different compone ... Cite

Cyclosporine therapy and the development of interstitial fibrosis in renal allografts

Journal Article Transplantation Proceedings · January 1, 1988 Cite

Allogeneic small bowel transplantation with cyclosporine and donor whole-body irradiation

Journal Article Transplantation Proceedings · January 1, 1988 This study was designed to investigate the ability of CsA to prevent rejection and GVHD in a totally allogeneic transplant between two rat strains with strong histoincompatibility as well as to determine the utility of combining donor WBI as an adjunct to ... Cite

Comparison of intravenous digital subtraction angiography and conventional arteriography in defining renal anatomy.

Journal Article Transplantation · January 1988 Intravenous digital subtraction renal angiography (IV-DSRA) is frequently used in the preoperative evaluation of living-related (LR) kidney donors. However, the true accuracy of IV-DSRA in the donor population is difficult to assess since abnormalities of ... Full text Link to item Cite

Antibody titers and cardiac allograft survival in the sensitized rat model: Effect of time after initial sensitization

Journal Article Transplantation Proceedings · January 1, 1988 We examined the kinetics of alloantibody induced by skin grafting and the fate of cardiac allografts placed in acutely and remotely sensitized rats. These results indicate that over 6 months time a decline in circulating antibody titer sufficient to avoid ... Cite

Hemolytic anemia is not a frequent complication of ABO unmatched renal allografts from living related donors.

Journal Article Transplant Proc · December 1987 In summary, we could not document an increased incidence of HA nor a detrimental effect of CyA use in our recipients of ABO-unmatched LRD kidneys. Thus, it would appear that the incidence of HA in this situation is low enough that no special pretreatment o ... Link to item Cite

Invited commentary

Journal Article World Journal of Surgery · October 1, 1987 Full text Cite

Causes of death in renal transplant recipients. A review of autopsy findings from 1966 through 1985.

Journal Article Arch Pathol Lab Med · October 1987 From 1966 through 1985, a total of 640 patients received 739 renal transplants at a single center transplantation program. Of 245 total deaths, a slide and chart review of all 116 autopsied cases (47%) identified the major causes of death as pneumonia (n = ... Link to item Cite

The influence of dose and dose rate of total lymphoid irradiation in the rat cardiac allograft model.

Journal Article Radiother Oncol · August 1987 Immunosuppression generated by total lymphoid irradiation (TLI) may be of use in solid organ transplantation. We have investigated the use of TLI in the rat cardiac allograft model. Lewis rats received TLI from a cobalt-60 machine. The daily dose was 1.25 ... Full text Link to item Cite

Humoral rejection of rat hepatic transplants by passive transfer of serum

Journal Article Transplantation Proceedings · April 29, 1987 Cite

Transplantation of the entire small bowel in inbred rats using cyclosporine.

Journal Article Transplantation · April 1987 Inbred strains of rats were used to analyze unidirectional host-versus-graft disease (transplant rejection) without graft-versus-host disease in small intestinal transplants and the immunosuppressive properties of cyclosporine (CsA). Forty-six Lewis rats r ... Full text Link to item Cite

Xenograft survival in two species combinations using total-lymphoid irradiation and cyclosporine.

Journal Article Transplantation · February 1987 Total lymphoid irradiation (TLI) has profound immunosuppressive actions and has been applied successfully to allotransplantation but not xenotransplantation. Cyclosporine (CsA) has not generally permitted successful xenotransplantation of organs but has no ... Full text Link to item Cite

Infiltrating cell phenotypes and patterns associated with hepatic allograft rejection or acceptance.

Journal Article Transplantation · February 1987 The association of inflammatory cell infiltration with orthotopic rat liver transplant rejection was studied by immunopathologic evaluation of allografts at different time points using high- and low-responder strain combinations. PVG(RT-1c) recipients of A ... Full text Link to item Cite

Peptic ulcer disease following renal transplantation.

Journal Article Transplant Proc · February 1987 Link to item Cite

Survival of rat hepatic allografts after treatment with donor splenocytes

Journal Article Surgical Forum · January 1, 1987 Cite

The role of modified self in the induction of antigen-specific suppressor cells in the rat

Journal Article Transplantation Proceedings · January 1, 1987 Cite

Hepatic transplantation into sensitized recipients. Demonstration of hyperacute rejection.

Journal Article Transplantation · January 1987 Hepatic transplantation into humorally presensitized patients has occasionally been performed without reported accelerated rejection. To study survival of orthotopic hepatic transplants in sensitized recipients a series of studies in rats were performed. L ... Full text Link to item Cite

Alpha 1-adrenergic effects and liver regeneration.

Journal Article Hepatology · 1987 The effects of several treatments involving alpha-adrenergic mechanisms upon the early stages of rat liver regeneration were examined. Catecholamine concentrations in rat plasma were measured at various times after hepatectomy and were found to be elevated ... Full text Link to item Cite

Combined total lymphoid irradiation and cyclosporine promote xenograft survival

Journal Article Transplantation Proceedings · January 1, 1987 Cite

Prolonged heart xenograft survival using combined total lymphoid irradiation and cyclosporine

Journal Article Journal of Heart Transplantation · December 1, 1986 Total lymphoid irradiation and cyclosporine have profound immunosuppressive properties and permit successful heart allotransplantation. Cyclosporine used alone has not permitted consistently successful transplantation between species in all cases. Total ly ... Cite

Temporary occlusion of the portal vein in the rat

Journal Article Transplantation Proceedings · January 1, 1986 Cite

The impact of donor renal abnormalities in cadaver transplantation

Journal Article Transplantation Proceedings · January 1, 1986 The original specifications for transplantable cadaver donor kidneys were extremely stringent. Only kidneys from the left side were used by some centers because of the fear of having an inadequate, short renal vein on the right side. Over time there has be ... Cite

Prolonged heart xenograft survival using combined total lymphoid irradiation and cyclosporine.

Journal Article J Heart Transplant · 1986 Total lymphoid irradiation and cyclosporine have profound immunosuppressive properties and permit successful heart allotransplantation. Cyclosporine used alone has not permitted consistently successful transplantation between species in all cases. Total ly ... Link to item Cite

Monitoring the donor-specific response of renal transplant patients by needle biopsy and long-term culture of alloreactive T-cell clones

Journal Article Transplantation Proceedings · January 1, 1986 Analyses of infiltrates present in rejecting renal transplants have demonstrated a predominance of T-cells. Although these cells have generally had a short life span in vitro, techniques for long-term propagation of them have recently been developed. In an ... Cite

Renal allograft cell infiltrates associated with irreversible rejection.

Journal Article Transplantation · December 1985 All 74 renal transplant biopsies performed between 11/78 and 8/84 at Duke University and Durham VA Medical Centers having cellular infiltrates that could be phenotyped by immunoperoxidase labeling were examined to identify histologic and immunopathologic f ... Full text Link to item Cite

Sensitivity and specificity of a monitoring test.

Journal Article Biometrics · December 1985 The usefulness of a diagnostic test is generally assessed by calculating the sensitivity and specificity, or the predictive value positive and predictive value negative of the test. When subjects are monitored periodically for evidence of disease, these ca ... Link to item Cite

Liver transplantation.

Journal Article Invest Radiol · November 1985 Full text Link to item Cite

Widely disseminated Cunninghamella mucormycosis in an adult renal transplant patient: case report and review of the literature.

Journal Article Am J Clin Pathol · June 1985 A case of widely disseminated mucormycosis involving Cunninghamella bertholletiae is reported. This represents the first report of Cunninghamella infection in a transplant patient and, to our knowledge, only the eighth reported case of human infection by t ... Full text Link to item Cite

Foreword

Chapter · January 1, 1985 Full text Cite

Renal transplant wastage: An international problem

Journal Article Transplantation Proceedings · January 1, 1985 Cite

The effect of cyclosporine, total lymphoid irradiation, and cobra venom factor on hyperacute rejection.

Journal Article J Heart Transplant · 1985 Transplantation into sensitized recipients is contraindicated due to the potential for hyperacute rejection. In order to study the mechanism of hyperacute rejection and the role of immunosuppression in the face of presensitization, we evaluated the effect ... Link to item Cite

A randomized study comparing leukocyte-depleted versus packed red cell transfusions in prospective cadaver renal allograft recipients.

Journal Article Transfusion · 1985 A prospective randomized study at a single renal transplant center between 1980 and 1982 compared the influence of leukocyte-depleted versus packed red cell pretransplantation blood transfusions on patient sensitization to leukocyte (HLA) antigens, likelih ... Full text Link to item Cite

Renal transplant monitoring with serum β-2-microglobulin and creatinine

Journal Article Transplantation Proceedings · January 1, 1985 Cite

Rapid serologic diagnosis of serum sickness from antithymocyte globulin therapy using enzyme immunoassay.

Journal Article Transplantation · December 1984 Although the use of antithymocyte globulin/antilymphocyte serum (ATG/ALS) has been shown to be beneficial in treating renal allograft rejection, the incidence and nature of serum sickness reactions following such treatment have received limited attention. ... Full text Link to item Cite

Reasons why kidneys removed for transplantation are not transplanted in the United States.

Journal Article Transplantation · December 1984 The Organ Center establishes by the South-Eastern Organ Procurement Foundation collected information on 575 kidneys procured but not transplanted in the United States. The greatest proportion, 393, were not transplanted because a crossmatch-negative recipi ... Full text Link to item Cite

Influence of changes in pretransplant sensitization on patient and graft survival in cadaver renal transplantation.

Journal Article Transplantation · August 1984 Analysis of 2778 primary and 606 regrafted cadaveric donor renal allograft recipients transplanted between June 1977 and July 1982 as part of the South-Eastern Organ Procurement Foundation (SEOPF) Prospective Study was performed to determine the influence ... Full text Link to item Cite

Cadaver renal transplantation ignoring peak-reactive sera in patients with markedly decreasing pretransplant sensitization.

Journal Article Transplantation · August 1984 A review of more than 3000 cadaver donor renal allograft recipients transplanted between June 1977 and July 1982 as part of the South-Eastern Organ Procurement Foundation (SEOPF) Prospective Study was performed to identify patients who received a transplan ... Full text Link to item Cite

Cimetidine for stress-ulcer prophylaxis.

Journal Article Crit Care Med · July 1984 Although cimetidine is more effective than a placebo for the prophylaxis of stress-induced ulcers, it has no advantage over titrated antacid dosing. Several comparative studies even suggest that combining cimetidine with antacid is no more effective than u ... Full text Link to item Cite

The influence of pretransplant transfusions, using different blood products, on patient sensitization and renal allograft survival.

Journal Article Transplantation · April 1984 An analysis of data collected during the South Eastern Organ Procurement Foundation (SEOPF) Prospective Study from 1977-1982 was performed to identify the relative effects of different blood products on patient sensitization and graft survival in cadaveric ... Full text Link to item Cite

Transplantation for polycystic kidney disease.

Journal Article Transplantation · July 1983 During the 4-year period from June 1977 to May 1981, a total of 108 patients with polycystic kidney disease and 2440 nonpolycystic patients received cadaver renal allografts in the Southeastern Organ Procurement Foundation (SEOPF) Prospective Study. There ... Full text Link to item Cite

Why do secondary cadaver renal transplants succeed? Results of the South-Eastern Organ Procurement Foundation prospective study, 1977-1982.

Journal Article J Urol · March 1983 We report the selective and therapeutic factors affecting multiple kidney transplant success from a prospective multicenter study of the South-Eastern Organ Procurement Foundation. From June 1977 to March 1982, 3,215 cadaver kidney transplants were perform ... Full text Link to item Cite

Transplantation tolerance produced with histocompatibility antigen-cell conjugates

Journal Article Transplantation Proceedings · January 1, 1983 The rationale for our efforts to induce immunologic tolerance includes the intravenous presentation of antigen, the employment of autologous lymphoid cells as tolerogenic self-carriers, and the utilization of a nonimmunogenic form of donor histocompatibili ... Cite

Fate of four cadaveric donor renal allografts with mesangial IgA deposits.

Journal Article Transplantation · April 1982 In the course of routine pretransplant cadaveric donor kidney biopsy examination, specimens from two donors were found to exhibit intense mesangial localization of IgA by immunofluorescence, with the presence of large immune complex-type deposits in these ... Full text Link to item Cite

Renal transplantation in highly sensitized patients

Journal Article Transplantation Proceedings · January 1, 1982 Cite

Brachial artery reconstruction using the heparin-bonded Sundt shunt.

Journal Article Surgery · March 1981 Fracture stabilization is often desirable prior to vascular repair in the management of major extremity injuries. This principle is particularly important when long vein grafts are required to minimize the risk of anastomotic disruption during the orthoped ... Link to item Cite

Creation and properties of histocompatibility antigen-cell conjugates. I. Preparation and immunological properties of rat histocompatibility antigens.

Journal Article Transplantation · June 1980 A necessary step in the induction of unresponsiveness to transplantation antigens is the preparation and presentation of tissue antigens in a suitable form. A method is presented for obtaining rat histocompatibility antigen in a soluble, "heptenic" form su ... Full text Link to item Cite

Creation and properties of histocompatibility antigen-cell conjugates. II. Antibody tolerance after treatment with donor histocompatibility antigen chemically coupled to recipient spleen cells.

Journal Article Transplantation · June 1980 Histocompatibility (HC) antigens from Lewis (RT-11) and ACI (RT-1a) rats were solubilized and their tolerogenic potential alone or when conjugated to cellular carriers was investigated. The tolerogenic carrier potential of whole cells, crude membranes, and ... Link to item Cite

Human amino acid excretion during and following an extended airborne alert.

Journal Article Aviation, space, and environmental medicine · May 1977 The urinary excretion of free amino acids was measured in 15 men who participated in a continuous airborne alert for an extended period of time. These men made up one of three teams which took turns so as to assure that at least one team remained airborne ... Cite

Flight-induced changes in human amino acid excretion.

Journal Article Aviation, space, and environmental medicine · January 1976 A biomedical appraisal of flight stress was made by means of a battery of urinary determinations on crewmen who participated in a 96-h airborne alert. The crewmen were divided into three teams, each consisting of 16 members and each manning an EC-135J airc ... Cite

Biomedical cost of low-level flight in a hot environment.

Journal Article Aviation, space, and environmental medicine · October 1975 The physiologic and performance effects of low-level reconnaissance flying in hot environments were documented and quantitated. RF-4C pilots and weapons system operators were studied in hot and cool seasons during both high and low missions to distinguish ... Cite

Prevention of decompression sickness during a simulated space docking mission.

Journal Article Aviation, space, and environmental medicine · July 1975 This study has shown that repetitive exchanges between the American Apollo space vehicle atmosphere of 100% oxygen at 5 psia (258 torr) and the Russian Soyuz spacecraft atmosphere of 30% oxygen-70% nitrogen at 10 psia (523 torr), as simulated in altitude c ... Cite

Über die erhöhte immunologische Reaktionsbereitschaft keimfreier Tiere gegenüber Transplantations- und anderen Antigenen

Journal Article Acta Chirurgica Austriaca · January 1, 1971 An keimfreien Ratten wurde eine raschere Abstoßung von Hautallotransplantaten im Vergleich zu konventionellen Tieren beobachtet. In Korrelation mit diesem Phänomen wurden Hinweise für eine ausgiebigere Antikörperproduktion bei den keimfreien Transplantatem ... Full text Cite