Guy Glenn Potter

Journal Article Med Image Anal · May 2024 Late-life depression (LLD) is a highly prevalent mood disorder occurring in older adults and is frequently accompanied by cognitive impairment (CI). Studies have shown that LLD may increase the risk of Alzheimer's disease (AD). However, the heterogeneity o ... Full text Link to item Cite

Accelerated Brain Atrophy, Microstructural Decline and Connectopathy in Age-Related Macular Degeneration.

Journal Article Biomedicines · January 10, 2024 Age-related macular degeneration (AMD) has recently been linked to cognitive impairment. We hypothesized that AMD modifies the brain aging trajectory, and we conducted a longitudinal diffusion MRI study on 40 participants (20 with AMD and 20 controls) to r ... Full text Open Access Link to item Cite

Brain Anatomy-Guided MRI Analysis for Assessing Clinical Progression of Cognitive Impairment with Structural MRI.

Conference Med Image Comput Comput Assist Interv · October 2023 Brain structural MRI has been widely used for assessing future progression of cognitive impairment (CI) based on learning-based methods. Previous studies generally suffer from the limited number of labeled training data, while there exists a huge amount of ... Full text Link to item Cite

Addressing multi-site functional MRI heterogeneity through dual-expert collaborative learning for brain disease identification.

Journal Article Hum Brain Mapp · August 1, 2023 Several studies employ multi-site rs-fMRI data for major depressive disorder (MDD) identification, with a specific site as the to-be-analyzed target domain and other site(s) as the source domain. But they usually suffer from significant inter-site heteroge ... Full text Link to item Cite

Reply.

Journal Article Occup Med (Lond) · May 18, 2023 Full text Link to item Cite

Reliable Cognitive Decline in Late-Life Major Depression.

Journal Article Arch Clin Neuropsychol · February 18, 2023 OBJECTIVE: Major depression in older adults increases the statistical likelihood of dementia. It is challenging to translate statistical evidence of cognitive decline at the group level into knowledge of individual cognitive outcomes. The objective of the ... Full text Link to item Cite

Unsupervised cross-domain functional MRI adaptation for automated major depressive disorder identification.

Journal Article Med Image Anal · February 2023 Resting-state functional magnetic resonance imaging (rs-fMRI) data have been widely used for automated diagnosis of brain disorders such as major depressive disorder (MDD) to assist in timely intervention. Multi-site fMRI data have been increasingly employ ... Full text Link to item Cite

Brain morphometric features predict depression symptom phenotypes in late-life depression using a deep learning model.

Journal Article Front Neurosci · 2023 OBJECTIVES: Our objective was to use deep learning models to identify underlying brain regions associated with depression symptom phenotypes in late-life depression (LLD). PARTICIPANTS: Diagnosed with LLD (N = 116) and enrolled in a prospective treatment s ... Full text Link to item Cite

The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial.

Journal Article Contemp Clin Trials · December 2022 BACKGROUND: To address the rising prevalence of Alzheimer's disease and related dementias, effective interventions that can be widely disseminated are warranted. The Preventing Alzheimer's with Cognitive Training study (PACT) investigates a commercially av ... Full text Link to item Cite

Perceived Adequacy of Infection Control Practices and Symptoms of Anxiety Among In-Person Elementary School Educators in Ontario.

Journal Article J Occup Environ Med · November 1, 2022 OBJECTIVE: The aim of this study was to examine the association between the perceived adequacy of infection control practices (ICPs) and symptoms of anxiety among educators in Ontario, Canada. METHODS: Data from 4947 educators were collected in December 20 ... Full text Link to item Cite

The psychosocial work environment among educators during the COVID-19 pandemic.

Journal Article Occup Med (Lond) · October 18, 2022 BACKGROUND: The education sector has been heavily impacted by COVID-19. While the impact on school-aged children has received much attention, less attention has focused on the experiences of educators. AIMS: To compare various dimensions of the psychosocia ... Full text Link to item Cite

Understanding Clinical Progression of Late-Life Depression to Alzheimer's Disease Over 5 Years with Structural MRI.

Conference Mach Learn Med Imaging · September 2022 Previous studies have shown that late-life depression (LLD) may be a precursor of neurodegenerative diseases and may increase the risk of dementia. At present, the pathological relationship between LLD and dementia, in particularly Alzheimer's disease (AD) ... Full text Link to item Cite

The impact of the COVID-19 pandemic on mental health of nurses in British Columbia, Canada using trends analysis across three time points.

Journal Article Ann Epidemiol · October 2021 PURPOSE: This study examined trends over time in the prevalence of anxiety and depression among Canadian nurses: 6 months before, 1-month after, and 3 months after COVID-19 was declared a pandemic. METHODS: This study adopted a repeated cross-sectional des ... Full text Link to item Cite

The Demand-Control Model as a Predictor of Depressive Symptoms-Interaction and Differential Subscale Effects: Prospective Analyses of 2212 German Employees.

Journal Article Int J Environ Res Public Health · August 6, 2021 Testing assumptions of the widely used demand-control (DC) model in occupational psychosocial epidemiology, we investigated (a) interaction, i.e., whether the combined effect of low job control and high psychological demands on depressive symptoms was stro ... Full text Link to item Cite

Labour Market Attachment, Workplace Infection Control Procedures and Mental Health: A Cross-Sectional Survey of Canadian Non-healthcare Workers during the COVID-19 Pandemic.

Journal Article Ann Work Expo Health · April 22, 2021 BACKGROUND: The COVID-19 pandemic has led to large proportions of the labour market moving to remote work, while others have become unemployed. Those still at their physical workplace likely face increased risk of infection, compared to other workers. The ... Full text Link to item Cite

Deep factor regression for computer-aided analysis of major depressive disorders with structural MRI data

Conference Proceedings - International Symposium on Biomedical Imaging · April 13, 2021 Major depressive disorder (MDD) is a prevalent and debilitating psychiatric mood disorder that affects millions of people worldwide. Conventional methods for MDD severity diagnosis usually rely on neuropsychological assessments that are subjective and susc ... Full text Cite

Psychosocial considerations in the assessment of hand transplant candidates: A single-center experience and brief literature review.

Journal Article Clin Transplant · April 2021 Vascularized composite allograft, including hand transplantation (HT), has gained wider usage as a reconstructive treatment over the past 30 years. HT recipients face unique psychosocial challenges compared to their solid organ and/or bone marrow transplan ... Full text Link to item Cite

Slower information processing speed is associated with persistent burnout symptoms but not depression symptoms in nursing workers.

Journal Article J Clin Exp Neuropsychol · February 2021 Introduction: Burnout and depression both occur with chronic work-related stress, and cognitive deficits have been found when symptom severity results in work disability. Less is known about cognitive deficits associated with milder symptoms among active w ... Full text Link to item Cite

The Interaction of Personality and Social Support on Prospective Suicidal Ideation in Men and Women With Late-Life Depression.

Journal Article Am J Geriatr Psychiatry · January 2021 OBJECTIVE: Evidence suggests a cross-sectional association between personality traits and suicidal ideation in LLD. Yet, it is unclear how personality may influence suicidal ideation over time in LLD, or whether such an association would be moderated by ps ... Full text Link to item Cite

Video-Enhanced Care Management for Medically Complex Older Adults with Cognitive Impairment.

Journal Article J Am Geriatr Soc · January 2021 OBJECTIVE: This pilot study assessed feasibility of video-enhanced care management for complex older veterans with suspected mild cognitive impairment (CI) and their care partners, compared with telephone delivery. DESIGN: Pilot randomized controlled trial ... Full text Link to item Cite

The Association between the Perceived Adequacy of Workplace Infection Control Procedures and Personal Protective Equipment with Mental Health Symptoms: A Cross-sectional Survey of Canadian Health-care Workers during the COVID-19 Pandemic: L'association entre le caractère adéquat perçu des procédures de contrôle des infections au travail et de l'équipement de protection personnel pour les symptômes de santé mentale. Un sondage transversal des travailleurs de la santé canadiens durant la pandémie COVID-19.

Journal Article Can J Psychiatry · January 2021 OBJECTIVES: To examine the relationship between perceived adequacy of personal protective equipment (PPE) and workplace-based infection control procedures (ICP) and mental health symptoms among a sample of health-care workers in Canada within the context o ... Full text Link to item Cite

Cerebral white matter connectivity, cognition, and age-related macular degeneration.

Journal Article Neuroimage Clin · 2021 Age-related macular degeneration (AMD) is a common retina disease associated with cognitive impairment in older adults. The mechanism(s) that account for the link between AMD and cognitive decline remain unclear. Here we aim to shed light on this issue by ... Full text Open Access Link to item Cite

Relationship between neural functional connectivity and memory performance in age-related macular degeneration.

Journal Article Neurobiol Aging · November 2020 Age-related macular degeneration (AMD) has been linked to memory deficits, with no established neural mechanisms. We collected resting-state brain functional magnetic resonance imaging and standardized verbal recall tests from 42 older adults with AMD and ... Full text Open Access Link to item Cite

Racially diverse participant registries to facilitate the recruitment of African Americans into presymptomatic Alzheimer's disease studies.

Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · August 2020 IntroductionThe Alzheimer's Disease Prevention Registry (ADPR) of the Joseph and Kathleen Bryan Alzheimer's Disease Research Center at Duke University has been successful in achieving a racially diverse and "research ready" cohort of cognitively h ... Full text Cite

Genome-wide screen to identify genetic loci associated with cognitive decline in late-life depression.

Journal Article Int Psychogeriatr · July 9, 2020 OBJECTIVE: This study sought to conduct a comprehensive search for genetic risk of cognitive decline in the context of geriatric depression. DESIGN: A genome-wide association study (GWAS) analysis in the Neurocognitive Outcomes of Depression in the Elderly ... Full text Link to item Cite

Lagged versus concurrent changes between burnout and depression symptoms and unique contributions from job demands and job resources.

Journal Article J Occup Health Psychol · December 2019 Burnout and depression pose significant threats to emotional and occupational functioning; however, questions exist over how these 2 conditions are associated with each other over time, and how these are related to underlying job stressors. The job demands ... Full text Link to item Cite

Brain network functional connectivity and cognitive performance in major depressive disorder.

Journal Article J Psychiatr Res · March 2019 BACKGROUND: Major depressive disorder (MDD) is one of the most prevalent and debilitating psychiatric disorders. Cognitive complaints are commonly reported in MDD and cognitive impairment is a criterion item for MDD diagnosis. As cognitive processes are in ... Full text Link to item Cite

Cognitive performance in antidepressant-free recurrent major depressive disorder.

Journal Article Depress Anxiety · August 2018 BACKGROUND: Cognitive complaints are common in depression, and cognition may be an important treatment target as cognitive problems often remain during remission and may contribute to recurrence risk. Previous studies of cognitive performance in depression ... Full text Link to item Cite

12-month trajectories of depressive symptoms among nurses-Contribution of personality, job characteristics, coping, and burnout.

Journal Article J Affect Disord · July 2018 BACKGROUND: Job related factors have been associated with higher risk for developing depression, but past studies lacked full consideration of individual factors such as personality and coping. We sought to evaluate associations of personality, coping, job ... Full text Link to item Cite

De novo belatacept in clinical vascularized composite allotransplantation.

Journal Article Am J Transplant · July 2018 Most immunosuppressive regimens used in clinical vascularized composite allotransplantation (VCA) have been calcineurin inhibitor (CNI)-based. As such, most recipients have experienced CNI-related side effects. Costimulation blockade, specifically CD28/B7 ... Full text Link to item Cite

Predictors of recurrence in remitted late-life depression.

Journal Article Depress Anxiety · July 2018 BACKGROUND: Late-life depression (LLD) is associated with a fragile antidepressant response and high recurrence risk. This study examined what measures predict recurrence in remitted LLD. METHODS: Individuals of age 60 years or older with a Diagnostic and ... Full text Link to item Cite

Work-Related Determinants of Burnout in a Nationally Representative Sample of German Employees: Results From the Study on Mental Health at Work.

Journal Article J Occup Environ Med · July 2018 OBJECTIVE: The aim of the study was to present first representative data on burnout measured as exhaustion in German employees. METHODS: Data were taken from the Study on Mental Health at Work (n = 4058). Computer-assisted personal interviews were conducte ... Full text Link to item Cite

Age, burnout and physical and psychological work ability among nurses.

Journal Article Occup Med (Lond) · May 23, 2018 BACKGROUND: The ageing of the US labour force highlights the need to examine older adults' physical and psychological ability to work, under varying levels of occupational burnout. AIMS: To examine how age and burnout interact in predicting physical and ps ... Full text Link to item Cite

Language processing in age-related macular degeneration associated with unique functional connectivity signatures in the right hemisphere.

Journal Article Neurobiol Aging · March 2018 Age-related macular degeneration (AMD) is a retinal disease associated with significant vision loss among older adults. Previous large-scale behavioral studies indicate that people with AMD are at increased risk of cognitive deficits in language processing ... Full text Open Access Link to item Cite

Putamen Volume Differences Among Older Adults: Depression Status, Melancholia, and Age.

Journal Article J Geriatr Psychiatry Neurol · January 2018 BACKGROUND: Individuals with major depressive disorder (MDD) may exhibit smaller striatal volumes reflecting deficits in the reward circuit. Deficits may change with age and be more pronounced among the melancholic subtype. Limited research has investigate ... Full text Link to item Cite

Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer's disease.

Journal Article PLoS One · 2018 Inner retina in Alzheimer's Disease (AD) may experience neuroinflammation resulting in atrophy. The objective of our study was to determine whether retinal GCIPL (ganglion cell-inner plexiform layer) or nerve fiber layer (NFL) thickness may serve as noninv ... Full text Link to item Cite

Dual-Task Gait and Alzheimer's Disease Genetic Risk in Cognitively Normal Adults: A Pilot Study.

Journal Article J Alzheimers Dis · 2018 BACKGROUND: Dual-task paradigms, in which an individual performs tasks separately and then concurrently, often demonstrate that people with neurodegenerative disorders experience more dual-task interference, defined as worse performance in the dual-task co ... Full text Link to item Cite

Relating Sensory, Cognitive, and Neural Factors to Older Persons' Perceptions about Happiness: An Exploratory Study.

Journal Article J Aging Res · 2018 Despite increased rates of disease, disability, and social losses with aging, seniors consistently report higher levels of subjective well-being (SWB), a construct closely related to happiness, than younger adults. In this exploratory study, we utilized an ... Full text Open Access Link to item Cite

Executive control, ERP and pro-inflammatory activity in emotionally exhausted middle-aged employees. Comparison between subclinical burnout and mild to moderate depression.

Journal Article Psychoneuroendocrinology · December 2017 Burnout is a syndrome occurring mainly in individuals with long-term stressful work. The main complaints are emotional exhaustion and reduced performance. Burnout also largely overlaps with depression. Both are characterized by increased incidence of infec ... Full text Link to item Cite

Longitudinal Cognitive Outcomes of Clinical Phenotypes of Late-Life Depression.

Journal Article Am J Geriatr Psychiatry · October 2017 OBJECTIVE: Late-life depression is associated with cognitive deficits and increased risk for cognitive decline. The purpose of the study was to determine whether clinical characteristics could serve as phenotypes informative of subsequent cognitive decline ... Full text Link to item Cite

Burnout is associated with changes in error and feedback processing.

Journal Article Biol Psychol · October 2017 Burnout is a pattern of complaints in individuals with emotionally demanding jobs that is often seen as a precursor of depression. One often reported symptom of burnout is cognitive decline. To analyze cognitive control and to differentiate between subclin ... Full text Link to item Cite

Cognitive functioning, aging, and work: A review and recommendations for research and practice.

Journal Article J Occup Health Psychol · July 2017 There is a larger proportion and number of older adults in the labor force than ever before. Furthermore, older adults in the workforce are working until later ages. Although a great deal of research has examined physical health and well-being of working o ... Full text Link to item Cite

Task difficulty modulates brain activation in the emotional oddball task.

Journal Article Brain Res · June 1, 2017 Previous functional magnetic resonance imaging (fMRI) studies have reported that task-irrelevant, emotionally salient events can disrupt target discrimination, particularly when attentional demands are low, while others demonstrate alterations in the distr ... Full text Open Access Link to item Cite

Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume.

Journal Article Neurobiol Aging · June 2017 Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of ... Full text Open Access Link to item Cite

Frontoparietal activation during visual conjunction search: Effects of bottom-up guidance and adult age.

Journal Article Hum Brain Mapp · April 2017 We conducted functional magnetic resonance imaging (fMRI) with a visual search paradigm to test the hypothesis that aging is associated with increased frontoparietal involvement in both target detection and bottom-up attentional guidance (featural salience ... Full text Open Access Link to item Cite

Assessment of Dentally Related Function in Individuals with Cognitive Impairment: The Dental Activities Test.

Journal Article J Am Geriatr Soc · March 2017 OBJECTIVES: To develop and validate the Dental Activities Test (DAT), a clinical tool for measuring dentally related function in cognitively impaired older adults. DESIGN: Cross-sectional study design. SETTING: Three assisted living residences in North Car ... Full text Link to item Cite

APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults.

Journal Article Brain Imaging Behav · February 2017 The APOE ε4 allele is associated with cognitive deficits and brain atrophy in older adults, but studies in younger adults are mixed. We examined APOE genotype effects on cognition and brain structure in younger adults and whether genotype effects differed ... Full text Link to item Cite

Decreased between-hemisphere connectivity strength and network efficiency in geriatric depression.

Journal Article Hum Brain Mapp · January 2017 White matter (WM) lesions have been recognized as a key etiological factor in geriatric depression. However, little is known about the topological pattern changes of WM in geriatric depression in the remitted state (RGD) and its relationship to depressive ... Full text Link to item Cite

Effects of early life stress on depression, cognitive performance and brain morphology.

Journal Article Psychol Med · January 2017 BACKGROUND: Childhood early life stress (ELS) increases risk of adulthood major depressive disorder (MDD) and is associated with altered brain structure and function. It is unclear whether specific ELSs affect depression risk, cognitive function and brain ... Full text Link to item Cite

Multiple Neuroimaging Measures for Examining Exercise-induced Neuroplasticity in Older Adults: A Quasi-experimental Study.

Journal Article Front Aging Neurosci · 2017 Physical exercise can improve physical and mental health. A number of imaging studies have examined the role of neuroplasticity in improving cognition with physical exercise; however, such neuroplasticity changes are not consistent across the reports partl ... Full text Link to item Cite

Appetite and Weight Loss Symptoms in Late-Life Depression Predict Dementia Outcomes.

Journal Article Am J Geriatr Psychiatry · October 2016 OBJECTIVE: Identify depression symptoms during active late-life depression (LLD) that predict conversion to dementia. METHODS: The authors followed a cohort of 290 participants from the Neurocognitive Outcomes of Depression in the Elderly study. All partic ... Full text Link to item Cite

Physical frailty in late-life depression is associated with deficits in speed-dependent executive functions.

Journal Article Int J Geriatr Psychiatry · May 2016 OBJECTIVE: The aim of this study was to examine the association between physical frailty and neurocognitive performance in late-life depression (LLD). METHODS: Cross-sectional design using baseline data from a treatment study of late-life depression was us ... Full text Link to item Cite

Effects of education and race on cognitive decline: An integrative study of generalizability versus study-specific results.

Journal Article Psychol Aging · December 2015 The objective of the study was to examine variability across multiple prospective cohort studies in level and rate of cognitive decline by race/ethnicity and years of education. We compare data across studies, we harmonized estimates of common latent facto ... Full text Link to item Cite

Cognitive functioning throughout the treatment history of clinical late-life depression.

Journal Article Int J Geriatr Psychiatry · October 2015 OBJECTIVE: Previous investigations into the relationship between late-life depressive symptoms and cognitive functioning have resulted in mixed findings concerning whether or not depressive symptoms and cognitive functioning are related. The mixed reports ... Full text Link to item Cite

Differential item functioning due to cognitive status does not impact depressive symptom measures in four heterogeneous samples of older adults.

Journal Article Int J Geriatr Psychiatry · September 2015 OBJECTIVE: The objective of this study is to determine whether differential item functioning (DIF) due to cognitive status impacted three depressive symptoms measures commonly used with older adults. METHODS: Differential item functioning in depressive sym ... Full text Link to item Cite

Appetite loss and neurocognitive deficits in late-life depression.

Journal Article Int J Geriatr Psychiatry · June 2015 OBJECTIVES: This study aimed to examine the association of appetite loss symptoms to neurocognitive performance in late-life depression (LLD). METHODS: This study used cross-sectional data from individuals aged 60+ years with major depressive disorder (N = ... Full text Link to item Cite

Disability but not social support predicts cognitive deterioration in late-life depression.

Journal Article International psychogeriatrics · May 2015 BackgroundDepression in late life is a risk factor for cognitive decline. Depression is also associated with increased disability and social support deficits; these may precede conversion to dementia and inform risk. In this study, we examined if ... Full text Cite

Phonemic fluency and brain connectivity in age-related macular degeneration: a pilot study.

Journal Article Brain Connect · March 2015 Age-related macular degeneration (AMD), the leading cause of blindness in developed nations, has been associated with poor performance on tests of phonemic fluency. This pilot study sought to (1) characterize the relationship between phonemic fluency and r ... Full text Open Access Link to item Cite

Demographic characteristics do not decrease the utility of depressive symptoms assessments: examining the practical impact of item bias in four heterogeneous samples of older adults.

Journal Article Int J Geriatr Psychiatry · January 2015 OBJECTIVE: Previous studies have identified differential item function (DIF) in depressive symptoms measures, but the impact of DIF has been rarely reported. Given the critical importance of depressive symptoms assessment among older adults, we examined wh ... Full text Link to item Cite

Altered Synchronizations among Neural Networks in Geriatric Depression.

Journal Article Biomed Res Int · 2015 Although major depression has been considered as a manifestation of discoordinated activity between affective and cognitive neural networks, only a few studies have examined the relationships among neural networks directly. Because of the known disconnecti ... Full text Link to item Cite

Amnestic mild cognitive impairment and incident dementia and Alzheimer's disease in geriatric depression.

Journal Article Int Psychogeriatr · December 2014 BACKGROUND: Memory impairment in geriatric depression is understudied, but may identify individuals at risk for development of dementia and Alzheimer's disease (AD). Using a neuropsychologically based definition of amnestic mild cognitive impairment (aMCI) ... Full text Link to item Cite

Age mediation of frontoparietal activation during visual feature search.

Journal Article Neuroimage · November 15, 2014 Activation of frontal and parietal brain regions is associated with attentional control during visual search. We used fMRI to characterize age-related differences in frontoparietal activation in a highly efficient feature search task, detection of a shape ... Full text Open Access Link to item Cite

Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age.

Journal Article Am J Psychiatry · November 1, 2014 OBJECTIVE: Genetic factors confer risk for neuropsychiatric phenotypes, but the polygenic etiology of these phenotypes makes identification of genetic culprits challenging. An approach to this challenge is to examine the effects of genetic variation on rel ... Full text Link to item Cite

More evidence for the benefits of cognitive activity over the lifespan.

Journal Article Evid Based Med · June 2014 Full text Link to item Cite

Clinical outcomes of older depressed patients with and without comorbid neuroticism.

Journal Article Int Psychogeriatr · December 2013 BACKGROUND: Neuroticism is a psychological construct that includes tendency to exhibit negative affect (NA), having poor stress tolerance and being at risk for depression and anxiety disorders. The consequences of neuroticism in the elderly adults are unde ... Full text Link to item Cite

Impact of aerobic exercise on neurobehavioral outcomes.

Journal Article Ment Health Phys Act · October 2013 Numerous studies have examined the relationship between physical activity and cognitive function, demonstrating that greater physical activity is associated with lower incidence of cognitive impairment in later life. Due to an increasingly large number of ... Full text Link to item Cite

A low-vision rehabilitation program for patients with mild cognitive deficits.

Journal Article JAMA Ophthalmol · July 2013 IMPORTANCE: We are unaware of any standardized protocols within low-vision rehabilitation (LVR) to address cognitive impairment. OBJECTIVE: To design and pilot-test an LVR program for patients with macular disease and cognitive deficits. DESIGN: The Memory ... Full text Link to item Cite

Neuropsychological predictors of dementia in late-life major depressive disorder.

Journal Article Am J Geriatr Psychiatry · March 2013 OBJECTIVE: Major depressive disorder is a likely risk factor for dementia, but some cases of major depressive disorder in older adults may actually represent a prodrome of this condition. The purpose of this study was to use neuropsychological test scores ... Full text Link to item Cite

Reduced comparison speed during visual search in late life depression.

Journal Article J Clin Exp Neuropsychol · 2013 Slowed information processing is a prominent deficit in late-life depression (LLD). To better differentiate processing speed components in LLD, we examined characteristics of visual search performance in 32 LLD and 32 control participants. Data showed spec ... Full text Open Access Link to item Cite

The Alzheimer's Disease Assessment Scale-Cognitive-Plus (ADAS-Cog-Plus): an expansion of the ADAS-Cog to improve responsiveness in MCI.

Journal Article Brain Imaging Behav · December 2012 BACKGROUND: The Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-Cog) is widely used in AD, but may be less responsive to change when used in people with mild cognitive impairment (MCI). METHODS: Participants from the Alzheimer's Disease Neuro ... Full text Link to item Cite

Memory deficit associated with worse functional trajectories in older adults in low-vision rehabilitation for macular disease.

Journal Article J Am Geriatr Soc · November 2012 OBJECTIVES: To examine whether performance on a brief memory test is related to functional outcomes in older individuals undergoing low-vision rehabilitation (LVR) for macular disease. DESIGN: Observational cohort study of individuals receiving outpatient ... Full text Link to item Cite

Association of attentional shift and reversal learning to functional deficits in geriatric depression.

Journal Article Int J Geriatr Psychiatry · November 2012 OBJECTIVE: The objective of this study is to examine the association between self-reported functional disability in depressed older adults and two types of executive function processes, attentional set shifting and reversal learning. METHODS: Participants ... Full text Link to item Cite

Neural correlates associated with cognitive decline in late-life depression.

Journal Article Am J Geriatr Psychiatry · August 2012 OBJECTIVES: Persistent cognitive impairment (PCI) after remission of depressive symptoms is a major adverse outcome of late-life depression (LLD). The purpose of this study was to examine neural substrates associated with PCI in LLD. DESIGN: Longitudinal s ... Full text Link to item Cite

Neuropsychological Predictors of Dementia in Late-Life Major Depressive Disorder.

Journal Article Am J Geriatr Psychiatry · March 11, 2012 OBJECTIVE:: Major depressive disorder is a likely risk factor for dementia, but some cases of major depressive disorder in older adults may actually represent a prodrome of this condition. The purpose of this study was to use neuropsychological test scores ... Full text Link to item Cite

Diffusion tensor imaging of cerebral white matter integrity in cognitive aging.

Journal Article Biochim Biophys Acta · March 2012 In this article we review recent research on diffusion tensor imaging (DTI) of white matter (WM) integrity and the implications for age-related differences in cognition. Neurobiological mechanisms defined from DTI analyses suggest that a primary dimension ... Full text Open Access Link to item Cite

Identification of MCI individuals using structural and functional connectivity networks.

Journal Article Neuroimage · February 1, 2012 Different imaging modalities provide essential complementary information that can be used to enhance our understanding of brain disorders. This study focuses on integrating multiple imaging modalities to identify individuals at risk for mild cognitive impa ... Full text Link to item Cite

Resting-state multi-spectrum functional connectivity networks for identification of MCI patients.

Journal Article PLoS One · 2012 In this paper, a high-dimensional pattern classification framework, based on functional associations between brain regions during resting-state, is proposed to accurately identify MCI individuals from subjects who experience normal aging. The proposed tech ... Full text Link to item Cite

Change in stress and social support as predictors of cognitive decline in older adults with and without depression.

Journal Article Int J Geriatr Psychiatry · December 2011 OBJECTIVE: The relationship between stress, social support, and cognition in geriatric depression is complex. In this study, we sought to examine whether an increase in stressful life events or a decrease in social support would lead to subsequent cognitiv ... Full text Link to item Cite

Incidence of dementia and cognitive impairment, not dementia in the United States.

Journal Article Ann Neurol · September 2011 OBJECTIVE: Estimates of incident dementia, and cognitive impairment, not dementia (CIND) (or the related mild cognitive impairment) are important for public health and clinical care policy. In this paper, we report US national incidence rates for dementia ... Full text Link to item Cite

Neuropsychiatric symptoms and the risk of institutionalization and death: the aging, demographics, and memory study.

Journal Article J Am Geriatr Soc · March 2011 OBJECTIVES: To examine the association between neuropsychiatric symptoms and risk of institutionalization and death. DESIGN: Analysis of longitudinal data. SETTING: The Aging, Demographics, and Memory Study (ADAMS). PARTICIPANTS: Five hundred thirty-seven ... Full text Link to item Cite

Caring for individuals with dementia and cognitive impairment, not dementia: findings from the aging, demographics, and memory study.

Journal Article J Am Geriatr Soc · March 2011 OBJECTIVES: To compare the characteristics and outcomes of caregivers of adults with dementia with those of caregivers of adults with cognitive impairment, not dementia (CIND). DESIGN: Cross-sectional. SETTING: In-home assessment for cognitive impairment a ... Full text Link to item Cite

Enriched white matter connectivity networks for accurate identification of MCI patients.

Journal Article Neuroimage · February 1, 2011 Mild cognitive impairment (MCI), often a prodromal phase of Alzheimer's disease (AD), is frequently considered to be a good target for early diagnosis and therapeutic interventions of AD. Recent emergence of reliable network characterization techniques has ... Full text Link to item Cite

Comorbid cognitive impairment and functional trajectories in low vision rehabilitation for macular disease.

Journal Article Aging Clin Exp Res · 2011 BACKGROUND AND AIMS: Comorbid cognitive impairment is common among visually impaired older adults. This study investigated whether baseline cognitive status predicts functional trajectories among older adults in low vision rehabilitation (LVR) for macular ... Full text Link to item Cite

Change in hippocampal volume on magnetic resonance imaging and cognitive decline among older depressed and nondepressed subjects in the neurocognitive outcomes of depression in the elderly study.

Journal Article Am J Geriatr Psychiatry · January 2011 INTRODUCTION: previous studies have linked hippocampal volume change and cognitive decline in older adults with dementia. The authors examined hippocampal volume change and cognitive change in older nondemented adults with and without major depression. MET ... Full text Link to item Cite

Altered cerebellar-cerebral functional connectivity in geriatric depression.

Journal Article PLoS One · 2011 Although volumetric and activation changes in the cerebellum have frequently been reported in studies on major depression, its role in the neural mechanism of depression remains unclear. To understand how the cerebellum may relate to affective and cognitiv ... Full text Link to item Cite

Accurate identification of MCI patients via enriched white-matter connectivity network

Journal Article Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · October 25, 2010 Mild cognitive impairment (MCI), often a prodromal phase of Alzheimer's disease (AD), is frequently considered to be a good target for early diagnosis and therapeutic interventions of AD. Recent emergence of reliable network characterization techniques hav ... Full text Cite

The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression.

Journal Article Am J Geriatr Psychiatry · April 2010 OBJECTIVE: The Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene is associated with geriatric depression. In studies of younger adults without depression, met allele carriers exhibit smaller hippocampal volumes and have poorer perf ... Full text Link to item Cite

Increasing awareness of clinical neuropsychology in the general public.

Journal Article Clin Neuropsychol · April 2010 We can only benefit from raising public awareness about the unique role of clinical neuropsychology in patient care and clinical research. Public awareness of the distinctive skills of our practitioners and researchers and the utility of our products may w ... Full text Link to item Cite

Prevalence of neuropsychiatric symptoms and their association with functional limitations in older adults in the United States: the aging, demographics, and memory study.

Journal Article J Am Geriatr Soc · February 2010 OBJECTIVES: To estimate the prevalence of neuropsychiatric symptoms and examine their association with functional limitations. DESIGN: Cross-sectional analysis. SETTING: The Aging, Demographics, and Memory Study (ADAMS). PARTICIPANTS: A sample of adults ag ... Full text Link to item Cite

Prevalence and patterns of comorbid cognitive impairment in low vision rehabilitation for macular disease.

Journal Article Arch Gerontol Geriatr · 2010 The prevalence of comorbid cognitive impairment among older adults referred to low vision rehabilitation (LVR) for macular disease is unknown. We performed cognitive testing on 101 adults aged 65 years or older with macular disease who were referred to The ... Full text Link to item Cite

Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites.

Journal Article Alzheimers Dement · November 2009 BACKGROUND: The diagnosis of cognitive impairment and dementia must reflect an increasingly diverse and aging United States population. This study compared direct testing and informant reports of cognition with clinical diagnoses of cognitive impairment an ... Full text Link to item Cite

Influence of the MTHFR C677T polymorphism on magnetic resonance imaging hyperintensity volume and cognition in geriatric depression.

Journal Article Am J Geriatr Psychiatry · October 2009 OBJECTIVE: The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) has been linked to unipolar major depressive disorder (MDD) and magnetic resonance imaging (MRI) hyperintensities. The authors examined the relationship between the MTHFR C677T polymorphi ... Full text Link to item Cite

Prevalence of depression among older Americans: the Aging, Demographics and Memory Study.

Journal Article Int Psychogeriatr · October 2009 BACKGROUND: Previous studies have attempted to provide estimates of depression prevalence in older adults. The Aging, Demographics and Memory Study (ADAMS) is a population-representative study that included a depression assessment, providing an opportunity ... Full text Link to item Cite

The COMT Val158Met polymorphism and cognition in depressed and nondepressed older adults.

Journal Article Int J Geriatr Psychiatry · October 2009 OBJECTIVE: The objective of the current study was to examine the relationship between the COMT Val(158)Met polymorphism and neuropsychological performance in depressed and nondepressed older adults. METHODS: One hundred and twenty-six clinically depressed ... Full text Link to item Cite

The moderating role of personality factors in the relationship between depression and neuropsychological functioning among older adults.

Journal Article Int J Geriatr Psychiatry · September 2009 OBJECTIVE: Depression is often associated with decreased cognitive performance among older adults. The current study focused on the association of neuropsychological functioning and personality traits in depressed and non-depressed older adults. METHODS: D ... Full text Link to item Cite

Perceived stress and everyday memory complaints among older adult women.

Journal Article Anxiety Stress Coping · July 2009 Memory complaints among older adults are often influenced by depression and anxiety, but the association of stress to memory complaints has received little attention. We examined the associations of perceived stress, life events, and activity level to ever ... Full text Link to item Cite

Parental education and late-life dementia in the United States.

Journal Article J Geriatr Psychiatry Neurol · March 2009 We investigated the relation between parental education and dementia in the United States. Participants in the Aging, Demographics, and Memory Study were included, with information regarding parental education obtained from the Health and Retirement Study. ... Full text Link to item Cite

Neuropsychological correlates of magnetic resonance imaging-defined subcortical ischemic depression.

Journal Article Int J Geriatr Psychiatry · March 2009 OBJECTIVE: The goal of the current study was to examine the neuropsychological profile of magnetic resonance imaging (MRI)-defined subcortical ischemic depression (SID). METHODS: Clinically depressed older adults with MRI-defined SID (n = 70) and depressed ... Full text Link to item Cite

Outcomes of older cognitively impaired individuals with current and past depression in the NCODE study.

Journal Article J Geriatr Psychiatry Neurol · March 2009 We examined the frequency and course of cognitive impairment, no dementia among a group of older patients enrolled in a longitudinal study of depression. Among 230 participants, 29 with baseline dementia diagnosis were excluded from further analyses. Among ... Full text Link to item Cite

Midlife activity predicts risk of dementia in older male twin pairs.

Journal Article Alzheimers Dement · September 2008 BACKGROUND: This was a prospective study of dementia to elucidate mechanisms of disease risk factors amenable to modification and specifically to determine whether midlife cognitive and physical leisure activities are associated with delayed onset or reduc ... Full text Link to item Cite

Neurocognitive correlates of response to treatment in late-life depression.

Journal Article Am J Geriatr Psychiatry · September 2008 UNLABELLED: Depression is often associated with neurocognitive deficits in older adults, particularly in the domains of information processing speed, episodic memory, and executive functions. Greater neurocognitive dysfunction while depressed is associated ... Full text Link to item Cite

Depressive state- and disease-related alterations in neural responses to affective and executive challenges in geriatric depression.

Journal Article Am J Psychiatry · July 2008 OBJECTIVE: Geriatric depression has been associated with a heterogeneous neuropathology. Identifying both depressive state-related and disease-related alterations in brain regions associated with emotion and cognitive function could provide useful diagnost ... Full text Link to item Cite

Associations of job demands and intelligence with cognitive performance among men in late life.

Journal Article Neurology · May 6, 2008 OBJECTIVE: To examine the association of job characteristics and intelligence to cognitive status in members of the National Academy of Sciences-National Research Council Twins Registry of World War II veterans. METHODS: Participants (n = 1,036) included i ... Full text Link to item Cite

Prevalence of cognitive impairment without dementia in the United States.

Journal Article Ann Intern Med · March 18, 2008 BACKGROUND: Cognitive impairment without dementia is associated with increased risk for disability, increased health care costs, and progression to dementia. There are no population-based prevalence estimates of this condition in the United States. OBJECTI ... Full text Link to item Cite

The effects of antidepressant medication adherence as well as psychosocial and clinical factors on depression outcome among older adults.

Journal Article Int J Geriatr Psychiatry · February 2008 OBJECTIVE: To examine the contribution of medication adherence to 12-month depression scores in the context of other psychosocial and clinical predictors of depression in a sample of older adults treated for depression. METHODS: Secondary analysis of a pro ... Full text Link to item Cite

Geriatric depression and cognitive impairment.

Journal Article Psychol Med · February 2008 Cognitive impairment is common in geriatric depression, and depressed individuals with co-morbid cognitive impairment are at increased risk for a number of adverse medical, psychiatric and cognitive outcomes. This review focuses on clinical issues surround ... Full text Link to item Cite

Depression and cognitive impairment in older adults

Journal Article Psychiatric Times · November 1, 2007 Cite

Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the neurocognitive outcomes of depression in the elderly study.

Journal Article Am J Geriatr Psychiatry · October 2007 OBJECTIVE: Several studies suggest that depression is a risk factor for development of dementia in the elderly. In a study of older depressed individuals, the authors examined both neuroimaging and genetic factors in development of dementia. The authors hy ... Full text Link to item Cite

Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders.

Journal Article Neuropsychopharmacology · October 2007 Poor task persistence is often observed among depressed individuals, and may be associated with some of the same frontal regions that are involved in depression. The current study explored the association between white-matter lesion volume in prefrontal co ... Full text Link to item Cite

Job demands and dementia risk among male twin pairs.

Journal Article Alzheimers Dement · July 2007 BACKGROUND: Job characteristics may influence dementia risk, but some types of job complexity remain to be examined. Twin studies provide a useful methodology to examine job differences between pairs who share many environmental and genetic influences. MET ... Full text Link to item Cite

Contribution of depression to cognitive impairment and dementia in older adults.

Journal Article Neurologist · May 2007 BACKGROUND: The objective of this review is to provide information for clinicians regarding current research and opinions on the association of depression to conditions of cognitive impairment and dementia. We also intend to integrate this current research ... Full text Link to item Cite

Persistent mild cognitive impairment in geriatric depression.

Journal Article Int Psychogeriatr · February 2007 BACKGROUND: Cognitive impairment often occurs with geriatric depression and impairments may persist despite remission of depression. Although clinical definitions of mild cognitive impairment (MCI) have typically excluded depression, a neuropsychological m ... Full text Link to item Cite

Prevalence of dementia in the United States: the aging, demographics, and memory study.

Journal Article Neuroepidemiology · 2007 AIM: To estimate the prevalence of Alzheimer's disease (AD) and other dementias in the USA using a nationally representative sample. METHODS: The Aging, Demographics, and Memory Study sample was composed of 856 individuals aged 71 years and older from the ... Full text Link to item Cite

Duke Twins Study of Memory in Aging in the NAS-NRC Twin Registry.

Journal Article Twin Res Hum Genet · December 2006 The Duke Twins Study of Memory in Aging is an ongoing, longitudinal study of cognitive change and dementia in the population-based National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry of World War II Male Veterans. The primary goa ... Full text Link to item Cite

Response inhibition and everyday memory complaints in older adult women.

Journal Article Int J Geriatr Psychiatry · December 2006 OBJECTIVE: To explore the association of executive functions to the everyday memory complaints of healthy older adults. METHODS: Ninety-nine community-dwelling women aged 60 and above were administered a battery that included neuropsychological tests of ex ... Full text Link to item Cite

Occupational characteristics and cognitive performance among elderly male twins.

Journal Article Neurology · October 24, 2006 OBJECTIVE: To examine the effect of occupational characteristics on cognitive status change in members of the NAS-NRC Twins Registry of World War II veterans. METHODS: Participants completed the modified Telephone Interview for Cognitive Status (TICS-m) on ... Full text Link to item Cite

The Aging, Demographics, and Memory Study: study design and methods.

Journal Article Neuroepidemiology · 2005 OBJECTIVE: We describe the design and methods of the Aging, Demographics, and Memory Study (ADAMS), a new national study that will provide data on the antecedents, prevalence, outcomes, and costs of dementia and "cognitive impairment, not demented" (CIND) ... Full text Link to item Cite

Age effects of coronary artery bypass graft on cognitive status change among elderly male twins.

Journal Article Neurology · December 28, 2004 BACKGROUND: Research regarding long-term cognitive outcome following coronary artery bypass graft (CABG) is inconsistent, which may be due in part to differential genetic and environmental influences within most study samples. METHODS: The authors examined ... Full text Link to item Cite

Prefrontal neuropsychological predictors of treatment remission in late-life depression.

Journal Article Neuropsychopharmacology · December 2004 Recent studies suggest that neuropsychological measures involving the prefrontal cortex are associated with treatment remission in late-life depression. To further explore this issue, we studied the neuropsychological performance of 110 depressed individua ... Full text Link to item Cite

Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study.

Journal Article J Geriatr Psychiatry Neurol · December 2004 A methodology is presented for following a cohort of older depressed patients to examine neurocognitive outcomes of depression. A total of 265 depressed individuals and 138 healthy, nondepressed controls age 60 and older who completed at least 1 year of fo ... Full text Link to item Cite

Sources of age differences on the Rey-Osterrieth Complex Figure Test

Journal Article Clinical Neuropsychologist · December 1, 1998 The contributions of visuo-spatial abilities, organization, and memory to adult age differences on the Rey-Osterrieth Complex Figure Test were evaluated by means of the Boston Qualitative Scoring System (BQSS), the standard 36-point system, and an extensio ... Full text Cite