Scholars@Duke
Harry Scott Swartzwelder

Harry Scott Swartzwelder

Adjunct Professor in the Department of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
hss@duke.edu
Duke Box 104790, Durham, NC 27708
323 Foster St., Durham, NC 27701

Selected Publications

Adolescent intermittent ethanol (AIE) produces lasting, sex-specific changes in rat body fat independent of changes in white blood cell composition.

Journal Article Front Physiol · 2024 Early initiation of alcohol use during adolescence, and adolescent binge drinking are risk factors for the development of alcohol use disorder later in life. Adolescence is a time of rapid sex-dependent neural, physiological, and behavioral changes as well ... Full text Link to item Cite

Adolescent intermittent ethanol exposure alters adult exploratory and affective behaviors, and cerebellar Grin2b expression in C57BL/6J mice.

Journal Article Drug Alcohol Depend · December 1, 2023 Binge drinking is one of the most common patterns (more than 90%) of alcohol consumption by young people. During adolescence, the brain undergoes maturational changes that influence behavioral control and affective behaviors, such as cerebellar brain volum ... Full text Link to item Cite

Acute and Chronic Ethanol Effects during Adolescence on Neuroimmune Responses: Consequences and Potential Pharmacologic Interventions.

Journal Article Cells · May 18, 2023 Heavy ethanol consumption during adolescence has been linked to neuroimmune response dysregulation and cognitive deficits in the developing adolescent brain. During adolescence, the brain is particularly susceptible to the pharmacological effects of ethano ... Full text Link to item Cite

Adolescent intermittent ethanol exposure enhances adult stress effects in male rats.

Journal Article Pharmacol Biochem Behav · February 2023 Binge patterns of alcohol use, prevalent among adolescents, are associated with a higher probability of developing alcohol use disorders (AUD) and other psychiatric disorders, like anxiety and depression. Additionally, adverse life events strongly predict ... Full text Link to item Cite

The Influence of Sex on Hippocampal Neurogenesis and Neurotrophic Responses on the Persistent Effects of Adolescent Intermittent Ethanol Exposure into Adulthood.

Journal Article Neuroscience · December 1, 2022 In the United States, approximately 90% of alcohol consumed by adolescents is binge drinking. Binge-like ethanol exposure during adolescence promotes dysregulation of neurotrophic responses and neurogenesis in the hippocampus. These effects include changes ... Full text Link to item Cite

Adolescent intermittent ethanol exposure reduces astrocyte-synaptic proximity in the adult medial prefrontal cortex in rats: Reversal by gabapentin.

Journal Article Addict Neurosci · December 2022 Alcohol consumption in adolescence causes multiple acute negative changes in neural and behavioral function that persist well into adulthood and possibly throughout life. The medial prefrontal cortex (mPFC) and dorsal hippocampus are critical for executive ... Full text Link to item Cite

Implementation and Effectiveness of a Veterans Affairs-Based Comprehensive Lung Cancer Survivorship Program.

Journal Article J Cardiopulm Rehabil Prev · May 1, 2022 PURPOSE: Few programs exist to address persistent impairment in functional status, quality of life, and mental health in lung cancer survivors. We aimed to determine whether a 12-wk multimodal survivorship program imparts clinical benefit. METHODS: Any pat ... Full text Link to item Cite

Sex-specific effects of adolescent intermittent ethanol exposure-induced dysregulation of hippocampal glial cells in adulthood.

Journal Article Alcohol · May 2022 Adolescent alcohol abuse is a significant public health concern, with approximately 4.3 million U.S. adolescents reporting monthly binge drinking. Excessive ethanol consumption during adolescence has been linked to dysregulation of the neuroimmune system, ... Full text Link to item Cite

Sex differences in the effects of adolescent intermittent ethanol exposure on exploratory and anxiety-like behavior in adult rats.

Journal Article Alcohol · February 2022 Adolescent intermittent ethanol (AIE) exposure in rodents has been shown to alter adult behavior in several domains, including learning and memory, social interaction, affective behavior, and ethanol self-administration. AIE has also been shown to produce ... Full text Link to item Cite

Negative and positive allosteric modulators of the α7 nicotinic acetylcholine receptor regulates the ability of adolescent binge alcohol exposure to enhance adult alcohol consumption.

Journal Article Front Behav Neurosci · 2022 Rationale and Objectives: Ethanol acts directly on the α7 Nicotinic acetylcholine receptor (α7). Adolescent-binge alcohol exposure (ABAE) produces deleterious consequences during adulthood, and data indicate that the α7 receptor regulates these damaging ev ... Full text Link to item Cite

Alcohol use and related consequences for monoracial and multiracial Native American/American Indian college students.

Journal Article Exp Clin Psychopharmacol · October 2021 Native American/American Indian (NA/AI) and Multiracial people (those who claim multiple racial identities) report notably high alcohol use compared to other racial groups in the United States. Nearly half of the NA/AI population is also Multiracial, yet N ... Full text Link to item Cite

Effects of adolescent intermittent ethanol on hippocampal expression of glutamate homeostasis and astrocyte-neuronal tethering proteins in male and female rats.

Journal Article J Neurosci Res · August 2021 Adolescent alcohol drinking is widely recognized as a significant public health problem, and evidence is accumulating that sufficient levels of consumption during this critical period of brain development have an enduring impact on neural and behavioral fu ... Full text Link to item Cite

The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents.

Chapter · 2021 Alcohol drinking is often initiated during adolescence, and this frequently escalates to binge drinking. As adolescence is also a period of dynamic neurodevelopment, preclinical evidence has highlighted that some of the consequences of binge drinking can b ... Full text Link to item Cite

Regulation of the deleterious effects of binge-like exposure to alcohol during adolescence by α7 nicotinic acetylcholine receptor agents: prevention by pretreatment with a α7 negative allosteric modulator and emulation by a α7 agonist in alcohol-preferring (P) male and female rats.

Journal Article Psychopharmacology (Berl) · September 2020 RATIONALE AND OBJECTIVES: Binge-like alcohol consumption during adolescence associates with several deleterious consequences during adulthood including an increased risk for developing alcohol use disorder (AUD) and other addictions. Replicated preclinical ... Full text Link to item Cite

Strategies for Referring Cancer Patients in a Smoking Cessation Program.

Journal Article Int J Environ Res Public Health · August 21, 2020 Most people who smoke and develop cancer are unable to quit smoking. To address this, many cancer centers have now opened smoking cessation programs specifically designed to help cancer patients to quit. An important question has now emerged-what is the mo ... Full text Open Access Link to item Cite

Enduring alterations in hippocampal astrocytesynaptic proximity following adolescent alcohol exposure: reversal by gabapentin.

Journal Article Neural Regen Res · August 2020 Adolescent alcohol abuse is a substantive public health problem that has been the subject of intensive study in recent years. Despite reports of a wide range of effects of adolescent intermittent ethanol (AIE) exposure on brain and behavior, little is know ... Full text Link to item Cite

“Mixed” Drinking Motivations: A Comparison of Majority, Multiracial, and Minority College Students

Journal Article Social Psychological and Personality Science · July 1, 2020 Social exclusion is associated with substance use, but the specific link between majority and minority racial group membership and substance use is unknown. We examined how social exclusion among racial majority (White), Multiracial, and racial minority (N ... Full text Cite

Effects of ethanol on plasma ghrelin levels in the rat during early and late adolescence.

Journal Article Alcohol · June 2020 Ghrelin is an appetite-regulating peptide that is primarily secreted by endocrine cells in the stomach and is implicated in regulation of alcohol consumption and alcohol-reinforced behaviors. In the present study, adolescent Sprague-Dawley rats received in ... Full text Link to item Cite

Alcohol use and consequences in matriculating US college students by prescription stimulant/opioid nonmedical misuse status.

Journal Article Addict Behav · November 2019 BACKGROUND: US college students have elevated prescription opioid and stimulant misuse rates, with frequent alcohol use and alcohol-related consequences (ARCs). To date, though, no research has examined relationships between opioid and/or stimulant misuse ... Full text Link to item Cite

Mechanisms of Persistent Neurobiological Changes Following Adolescent Alcohol Exposure: NADIA Consortium Findings.

Journal Article Alcohol Clin Exp Res · September 2019 The Neurobiology of Adolescent Drinking in Adulthood (NADIA) Consortium has focused on the impact of adolescent binge drinking on brain development, particularly on effects that persist into adulthood. Adolescent binge drinking is common, and while many fa ... Full text Link to item Cite

Changes in Neuroimmune and Neuronal Death Markers after Adolescent Alcohol Exposure in Rats are Reversed by Donepezil.

Journal Article Sci Rep · August 20, 2019 Adolescent intermittent ethanol (AIE) exposure diminishes neurogenesis and dendritic spine density in the dentate gyrus. The cholinesterase inhibitor, donepezil (Aricept), reverses AIE effects on dendritic spines, possibly by interacting with inflammatory ... Full text Link to item Cite

General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity.

Journal Article Neuropharmacology · May 15, 2019 Accumulating evidence indicates that exposure to general anesthetics during infancy and childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and, to a lesser extent, increased incidence of behavioral disorders. Unfortuna ... Full text Link to item Cite

Region-Specific Differences in Morphometric Features and Synaptic Colocalization of Astrocytes During Development.

Journal Article Neuroscience · February 21, 2019 It is well established that astrocytes play pivotal roles in neuronal synapse formation and maturation as well as in the modulation of synaptic transmission. Despite their general importance for brain function, relatively little is known about the maturati ... Full text Link to item Cite

Sex Differences in Photic Entrainment and Sensitivity to Ethanol-Induced Chronodisruption in Adult Mice After Adolescent Intermittent Ethanol Exposure.

Journal Article Alcohol Clin Exp Res · November 2018 BACKGROUND: Evidence supports a role for the circadian system in alcohol use disorders, but the impact of adolescent alcohol exposure on circadian timing later in life is unknown. Acute ethanol (EtOH) attenuates circadian photic phase-resetting in adult, b ... Full text Link to item Cite

Donepezil Reverses Dendritic Spine Morphology Adaptations and Fmr1 Epigenetic Modifications in Hippocampus of Adult Rats After Adolescent Alcohol Exposure.

Journal Article Alcohol Clin Exp Res · April 2018 BACKGROUND: Adolescent intermittent ethanol (AIE) exposure produces persistent impairments in cholinergic and epigenetic signaling and alters markers of synapses in the hippocampal formation, effects that are thought to drive hippocampal dysfunction in adu ... Full text Link to item Cite

Adolescent Ethanol Exposure Enhances NMDA Receptor-Mediated Currents in Hippocampal Neurons: Reversal by Gabapentin.

Journal Article Sci Rep · October 13, 2017 Adolescent intermittent ethanol (AIE) exposure compromises neural function into adulthood. We have reported that astrocyte-secreted thrombospondins, and their target neuronal receptors (α2δ-1) are upregulated in the hippocampus in adulthood after AIE, sugg ... Full text Link to item Cite

Behavioral Inefficiency on a Risky Decision-Making Task in Adulthood after Adolescent Intermittent Ethanol Exposure in Rats.

Journal Article Sci Rep · July 5, 2017 Adolescence is a period of development in neural circuits that are critical for adult functioning. There is a relationship between alcohol exposure and risky decision-making, though the enduring effects of adolescent ethanol exposure on risky decision-maki ... Full text Link to item Cite

Alcohol-Related Blackouts, Negative Alcohol-Related Consequences, and Motivations for Drinking Reported by Newly Matriculating Transgender College Students.

Journal Article Alcohol Clin Exp Res · May 2017 BACKGROUND: Many transgender college students struggle with identity formation and other emotional, social, and developmental challenges associated with emerging adulthood. A potential maladaptive coping strategy employed by such students is heavy drinking ... Full text Link to item Cite

Differential Sensitivity to Ethanol-Induced Circadian Rhythm Disruption in Adolescent and Adult Mice.

Journal Article Alcohol Clin Exp Res · January 2017 BACKGROUND: Growing evidence supports a central role for the circadian system in alcohol use disorders, but few studies have examined this relationship during adolescence. In mammals, circadian rhythms are regulated by the suprachiasmatic nucleus, a biolog ... Full text Link to item Cite

Erratum

Journal Article Alcoholism: Clinical and Experimental Research · August 2016 Full text Cite

Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure

Conference PLoS ONE · May 1, 2016 Adolescent alcohol use is the strongest predictor for alcohol use disorders. In rodents, adolescents have distinct responses to acute ethanol, and prolonged alcohol exposure during adolescence can maintain these phenotypes into adulthood. One brain region ... Full text Cite

Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure.

Journal Article PLoS One · 2016 Adolescent alcohol use is the strongest predictor for alcohol use disorders. In rodents, adolescents have distinct responses to acute ethanol, and prolonged alcohol exposure during adolescence can maintain these phenotypes into adulthood. One brain region ... Full text Link to item Cite

Adolescent Intermittent Alcohol Exposure: Dysregulation of Thrombospondins and Synapse Formation are Associated with Decreased Neuronal Density in the Adult Hippocampus.

Journal Article Alcohol Clin Exp Res · December 2015 BACKGROUND: Adolescent intermittent alcohol exposure (AIE) has profound effects on neuronal function. We have previously shown that AIE causes aberrant hippocampal structure and function that persists into adulthood. However, the possible contributions of ... Full text Link to item Cite

Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood.

Journal Article Alcohol Clin Exp Res · June 2015 BACKGROUND: Human adolescence is a crucial stage of neurological development during which ethanol (EtOH) consumption is often at its highest. Alcohol abuse during adolescence may render individuals at heightened risk for subsequent alcohol abuse disorders, ... Full text Link to item Cite

Adolescent Intermittent Alcohol Exposure: Deficits in Object Recognition Memory and Forebrain Cholinergic Markers.

Journal Article PLoS One · 2015 The long-term effects of intermittent ethanol exposure during adolescence (AIE) are of intensive interest and investigation. The effects of AIE on learning and memory and the neural functions that drive them are of particular interest as clinical findings ... Full text Link to item Cite

Adolescent alcohol exposure alters GABAA receptor subunit expression in adult hippocampus.

Journal Article Alcohol Clin Exp Res · November 2014 BACKGROUND: The long-term consequences of adolescent alcohol abuse that persist into adulthood are poorly understood and have not been widely investigated. We have shown that intermittent exposure to alcohol during adolescence decreased the amplitude of GA ... Full text Link to item Cite

Adolescent alcohol exposure and persistence of adolescent-typical phenotypes into adulthood: a mini-review.

Journal Article Neurosci Biobehav Rev · September 2014 Alcohol use is typically initiated during adolescence, which, along with young adulthood, is a vulnerable period for the onset of high-risk drinking and alcohol abuse. Given across-species commonalities in certain fundamental neurobehavioral characteristic ... Full text Link to item Cite

Effect of sub-chronic intermittent ethanol exposure on spatial learning and ethanol sensitivity in adolescent and adult rats.

Journal Article Alcohol · June 2014 It has become clear that adolescence is a period of distinct responsiveness to the acute effects of ethanol on learning and other cognitive functions. However, the effects of repeated intermittent ethanol exposure during adolescence on learning and cogniti ... Full text Link to item Cite

ISOFLURANE EXPOSURE ENHANCES ETHANOL-RELATED BEHAVIORAL RESPONSES IN ADOLESCENT RATS

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · June 1, 2014 Link to item Cite

Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice.

Journal Article PLoS One · 2014 The human apolipoprotein ε4 allele (APOE4) has been implicated as one of the strongest genetic risk factors associated with Alzheimer's disease (AD) and in influencing normal cognitive functioning. Previous studies have demonstrated that mice expressing hu ... Full text Link to item Cite

Long-term modulation of A-type K(+) conductances in hippocampal CA1 interneurons in rats after chronic intermittent ethanol exposure during adolescence or adulthood.

Journal Article Alcohol Clin Exp Res · December 2013 BACKGROUND: Chronic alcohol use, especially exposure to alcohol during adolescence or young adulthood, is closely associated with cognitive deficits that may persist into adulthood. Therefore, it is essential to identify possible neuronal mechanisms underl ... Full text Link to item Cite

Enduring effects of adolescent drug exposure.

Journal Article Biol Psychiatry · October 1, 2013 Full text Link to item Cite

Binge-pattern ethanol exposure during adolescence, but not adulthood, causes persistent changes in GABAA receptor-mediated tonic inhibition in dentate granule cells.

Journal Article Alcohol Clin Exp Res · July 2013 BACKGROUND: In recent years, it has become clear that acute ethanol (EtOH) affects various neurobiological and behavioral functions differently in adolescent animals than in adults. However, less is known about the long-term neural consequences of chronic ... Full text Link to item Cite

Long-term effects of chronic intermittent ethanol exposure in adolescent and adult rats: radial-arm maze performance and operant food reinforced responding.

Journal Article PLoS One · 2013 BACKGROUND: Adolescence is not only a critical period of late-stage neurological development in humans, but is also a period in which ethanol consumption is often at its highest. Given the prevalence of ethanol use during this vulnerable developmental peri ... Full text Open Access Link to item Cite

Effects of acute or chronic ethanol exposure during adolescence on behavioral inhibition and efficiency in a modified water maze task.

Journal Article PLoS One · 2013 Ethanol is well known to adversely affect frontal executive functioning, which continues to develop throughout adolescence and into young adulthood. This is also a developmental window in which ethanol is misused by a significant number of adolescents. We ... Full text Link to item Cite

Effects of ethanol, Δ(9)-tetrahydrocannabinol, or their combination on object recognition memory and object preference in adolescent and adult male rats.

Journal Article Neurosci Lett · October 3, 2012 Recent advances have been made in our understanding of the deleterious effects of both ethanol and THC on adolescent behavior and brain development. However, very little is known about the combined effects of EtOH+THC during adolescence, a time in which th ... Full text Link to item Cite

The NMDA receptor in epilepsy

Chapter · March 22, 2012 Few things have generated more excitement in the field of epilepsy than studies suggesting that N-methyl-d-aspartate (NMDA) receptors may play a role in the development and expression of seizures. It is possible that antagonists of the NMDA receptor channe ... Full text Cite

In the rat, chronic intermittent ethanol exposure during adolescence alters the ethanol sensitivity of tonic inhibition in adulthood.

Journal Article Alcohol Clin Exp Res · February 2012 BACKGROUND: Alcohol drinking by adolescents is a major public health concern. Adolescents tend to drink in a chronic, intermittent, that is, "binge," pattern, and such patterns of ethanol exposure are associated with increased risk of neurotoxicity and the ... Full text Link to item Cite

GABA transport modulates the ethanol sensitivity of tonic inhibition in the rat dentate gyrus.

Journal Article Alcohol · September 2011 In recent years, the effect of ethanol on tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABA(A)Rs) has become a topic of intensive investigation and some controversy. The high ethanol sensitivity of extrasynaptic GABA(A) receptors containin ... Full text Link to item Cite

The synthetic cannabinoid WIN 55212-2 differentially modulates thigmotaxis but not spatial learning in adolescent and adult animals.

Journal Article Neurosci Lett · January 10, 2011 Unlike Δ(9)-THC, the synthetic compound WIN 55212-2 (WIN) is a full agonist of endogenous cannabinoid receptors. Previous work has shown Δ(9)-THC to affect adolescent and adult animals differently on numerous behavioral measures of spatial memory, anxiety, ... Full text Link to item Cite

Role of cannabinoid receptor type 1 desensitization in greater tetrahydrocannabinol impairment of memory in adolescent rats.

Journal Article J Pharmacol Exp Ther · November 2010 Adolescence is a well defined developmental period during which marijuana use is common. However, little is known about the response to marijuana in adolescents compared with adults. We have shown previously that adolescent rats are more impaired than adul ... Full text Link to item Cite

Differential sensitivity of hippocampal interneurons to ethanol in adolescent and adult rats.

Journal Article J Pharmacol Exp Ther · October 2010 Ethanol (EtOH) promotes GABAergic synaptic transmission in the central nervous system. We have shown that EtOH enhances the frequency of GABA(A) receptor-mediated spontaneous inhibitory postsynaptic currents less powerfully in hippocampal CA1 pyramidal neu ... Full text Link to item Cite

Modulation of NMDA and AMPA-mediated synaptic transmission by CB1 receptors in frontal cortical pyramidal cells.

Journal Article Brain Res · June 25, 2010 Although the endogenous cannabinoid system modulates a variety of physiological and pharmacological processes, the specific role of cannabinoid CB1 receptors in the modulation of glutamatergic neurotransmission and neural plasticity is not well understood. ... Full text Link to item Cite

CELL SPECIFIC AND AGE-DEPENDENT EFFECTS OF ETHANOL ON HIPPOCAMPAL INHIBITION

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · June 1, 2010 Link to item Cite

Predictors of nonmedical ADHD medication use by college students.

Journal Article J Atten Disord · May 2010 OBJECTIVE: To identify the predictors of nonmedical ADHD medication use by college students. PARTICIPANTS: A total of 843 undergraduates attending one public or one private university in southeastern United States. METHOD: Students completed a Web-based su ... Full text Link to item Cite

Motives and perceived consequences of nonmedical ADHD medication use by college students: are students treating themselves for attention problems?

Journal Article J Atten Disord · November 2009 OBJECTIVE: This study examines why college students without a prescription take ADHD medication, what they perceive the consequences of this to be, and whether attention problems are associated with this behavior. METHOD: More than 3,400 undergraduates att ... Full text Link to item Cite

Self-reported ADHD and adjustment in college: cross-sectional and longitudinal findings.

Journal Article J Atten Disord · November 2009 OBJECTIVE: To examine the association between self-reported ADHD and college adjustment. PARTICIPANTS: Study 1 included nearly 3400 undergraduates attending a public and private university. Study 2 included 846 students who participated during freshman and ... Full text Link to item Cite

The misuse and diversion of prescribed ADHD medications by college students.

Journal Article J Atten Disord · September 2009 OBJECTIVE: This study assesses the misuse and diversion of prescribed attention-deficit/hyperactivity disorder (ADHD) medications. METHOD: One hundred fifteen students, attending two universities, with prescriptions for ADHD medications completed a Web sur ... Full text Link to item Cite

Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih.

Journal Article J Neurophysiol · January 2009 Ethanol (EtOH) has powerful effects on GABA(A) receptor-mediated neurotransmission, and we have previously shown that EtOH-induced enhancement of GABA(A) receptor-mediated synaptic transmission in the hippocampus is developmentally regulated. Because synap ... Full text Link to item Cite

Inbound college students drink heavily during the summer before their freshman year: Implications for education and prevention efforts

Journal Article American Journal of Health Education · January 1, 2009 Background: Alcohol misuse among college students remains a pervasive problem. Relatively little is known about alcohol consumption by incoming students during the summer between high school graduation and the start of the freshman year. It is possible tha ... Full text Cite

The novel micro-opioid receptor antagonist, [N-allyl-Dmt(1)]endomorphin-2, attenuates the enhancement of GABAergic neurotransmission by ethanol.

Journal Article Alcohol Alcohol · 2009 AIMS: We investigated the effects of [N-allyl-Dmt(1)]endomorphin-2 (TL-319), a novel and highly potent micro-opioid receptor antagonist, on ethanol (EtOH)-induced enhancement of GABA(A) receptor-mediated synaptic activity in the hippocampus. METHODS: Evoke ... Full text Link to item Cite

Underage alcohol use: summary of developmental processes and mechanisms: ages 16-20.

Journal Article Alcohol Res Health · 2009 Late adolescence (i.e., the age-group between 16 and 20 years) is characterized by significant changes in neurological and cognitive processes, behavioral and social functioning, and relational and physical contexts as the individual moves toward adulthood ... Link to item Cite

Slamming on the brakes: Developmental differences in ethanol-induced neuronal inhibition

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · June 1, 2008 Link to item Cite

Adjustment to college in students with ADHD.

Journal Article J Atten Disord · May 2008 OBJECTIVE: To examine college adjustment in students reporting an ADHD diagnosis and the effect of medication treatment on students' adjustment. METHOD: 1,648 first-semester freshmen attending a public and a private university completed a Web-based survey ... Full text Link to item Cite

Early ethanol consumption predicts relapse-like behavior in adolescent male rats.

Journal Article Alcohol Clin Exp Res · May 2008 BACKGROUND: Alcohol abuse disorders emerge over time with repeated consumption of ethanol, but not all ethanol drinkers develop these disorders. There are pre-existing characteristics that indicate which drinkers are most likely to abuse alcohol. Adolescen ... Full text Link to item Cite

A developmental perspective on alcohol and youths 16 to 20 years of age.

Journal Article Pediatrics · April 2008 Late adolescence (ie, 16-20 years of age) is a period characterized by escalation of drinking and alcohol use problems for many and by the onset of an alcohol use disorder for some. This heightened period of vulnerability is a joint consequence of the cont ... Full text Link to item Cite

Differential sensitivity of GABA A receptor-mediated IPSCs to cannabinoids in hippocampal slices from adolescent and adult rats.

Journal Article J Neurophysiol · September 2007 The impairment of learning and memory is one of the most powerful and least understood effects of marijuana although the hippocampal formation appears to be one CNS region mediating these effects. We have shown that systemic injection of Delta9-tetrahydroc ... Full text Link to item Cite

Sex differences in the effects of delta9-tetrahydrocannabinol on spatial learning in adolescent and adult rats.

Journal Article Behav Pharmacol · September 2007 Like other recreational drugs, cannabinoids may produce different effects in men and women. In this study we measured the effects of delta9-tetrahydrocannabinol (THC) on spatial learning in two groups that are underrepresented in drug research--females and ... Full text Link to item Cite

Differential anxiogenic, aversive, and locomotor effects of THC in adolescent and adult rats.

Journal Article Psychopharmacology (Berl) · May 2007 RATIONALE: Unpleasant side effects of drugs of abuse often limit their repeated use; however, such effects may be attenuated in adolescents compared to adults. OBJECTIVES: We investigated whether the anxiogenic, aversive, or locomotor effects of delta-9-te ... Full text Link to item Cite

Magnitude and ethanol sensitivity of tonic GABAA receptor-mediated inhibition in dentate gyrus changes from adolescence to adulthood.

Journal Article J Neurophysiol · May 2007 Ethanol consumption by adolescents is a public health problem of striking importance. Educational and clinical efforts to address this problem have been aided by recent neurobehavioral studies indicating that ethanol disrupts memory and memory-related brai ... Full text Link to item Cite

Executive function deficits in acute stroke.

Journal Article Arch Phys Med Rehabil · February 2007 OBJECTIVES: To establish the frequency of executive dysfunction during acute hospitalization for stroke and to examine the relationship of that dysfunction to stroke severity and premorbid characteristics. DESIGN: Inception cohort study. SETTING: Inpatient ... Full text Link to item Cite

Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.

Journal Article Bioorg Med Chem · February 1, 2007 N-Allylation (-CH(2)-CHCH(2)) of [Dmt(1)]endomorphins yielded the following: (i) [N-allyl-Dmt(1)]endomorphin-2 (Dmt=2',6'-dimethyl-l-tyrosine) (12) and [N-allyl-Dmt(1)]endomorphin-1 (15) (K(i)mu=0.45 and 0.26nM, respectively) became mu-antagonists (pA(2)=8 ... Full text Link to item Cite

Many college freshmen drink at levels far beyond the binge threshold.

Journal Article Alcohol Clin Exp Res · June 2006 BACKGROUND: Binge drinking is a dichotomous variable that allows researchers to sort students into categories based upon a specific threshold of consumption, commonly 4 (females) or 5 (males) drinks. Crossing the binge threshold increases the risk of negat ... Full text Link to item Cite

Differential effects of delta9-THC on learning in adolescent and adult rats.

Journal Article Pharmacol Biochem Behav · March 2006 Marijuana use remains strikingly high among young users in the U.S., and yet few studies have assessed the effects of delta9-tetrahydrocannabinol (THC) in adolescents compared to adults. This study measured the effects of THC on male adolescent and adult r ... Full text Link to item Cite

Developmental differences in the sensitivity of spontaneous and miniature IPSCs to ethanol.

Journal Article Alcohol Clin Exp Res · January 2006 BACKGROUND: Ethanol (EtOH) consumption by juveniles and adolescents is an important public health problem. Recent studies have indicated that adolescent animals are less sedated by EtOH than adult animals and experience less motor impairment. Thus, human a ... Full text Link to item Cite

Sedative and GABAergic effects of ethanol on male and female rats.

Journal Article Alcohol Clin Exp Res · January 2006 BACKGROUND: Women consume less alcohol than men, and yet they are more susceptible than men to the negative medical consequences of alcohol use, such as cirrhosis of the liver, cardiac disease, and cognitive impairments. This sex difference is also reflect ... Full text Link to item Cite

Alcohol's effects on the adolescent brain: What can be learned from animal models

Journal Article Alcohol Research and Health · December 1, 2005 Because of legal and ethical constraints on alcohol research in human adolescents, many studies of alcohol's effects on the developing brain have been conducted in animal models, primarily rats and mice. The adolescent brain may be uniquely sensitive to al ... Cite

Inconsistencies between actual and estimated blood alcohol concentrations in a field study of college students: do students really know how much they drink?

Journal Article Alcohol Clin Exp Res · September 2005 BACKGROUND: Alcohol use by college students is commonly measured through the use of surveys. The validity of such data hinge on the assumption that students are aware of how much alcohol they actually consume. Recent studies call this assumption into quest ... Full text Link to item Cite

Adolescent vulnerabilities to chronic alcohol or nicotine exposure: findings from rodent models.

Journal Article Alcohol Clin Exp Res · September 2005 This article presents an overview of the proceedings from a symposium entitled "Is adolescence special? Possible age-related vulnerabilities to chronic alcohol or nicotine exposure," organized by Susan Barron and Linda Spear and held at the 2004 Research S ... Full text Link to item Cite

Age and gender effects on the sedative potency of ethanol

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · May 1, 2005 Link to item Cite

College students lack knowledge of standard drink volumes: implications for definitions of risky drinking based on survey data.

Journal Article Alcohol Clin Exp Res · April 2005 BACKGROUND: College students tend to pour single servings of beer and liquor that are larger than commonly used standards. The reasons for this are unknown. Students might overpour because they lack knowledge of standard serving sizes. Alternatively, they ... Full text Link to item Cite

Adolescence: booze, brains, and behavior.

Journal Article Alcohol Clin Exp Res · February 2005 This article represents the proceedings of a symposium at the 2004 Research Society on Alcoholism meeting in Vancouver, British Columbia, Canada, organized and chaired by Peter M. Monti and Fulton T. Crews. The presentations and presenters were (1) Introdu ... Full text Link to item Cite

Age-related effects of alcohol on memory and memory-related brain function in adolescents and adults.

Journal Article Recent Dev Alcohol · 2005 As detailed in this brief review, there is now clear evidence that adolescence represents a unique stage of brain development. Changes in brain organization and function during adolescence are widespread, and include intense rewiring in the frontal lobes a ... Full text Link to item Cite

Executive functioning early in abstinence from alcohol.

Journal Article Alcohol Clin Exp Res · September 2004 BACKGROUND: Executive dysfunction is among the cognitive impairments that may persist after abstinence in alcohol-dependent persons. The type(s) and extent of executive dysfunction early in abstinence have not been well characterized, but they may have imp ... Full text Link to item Cite

Hippocampal function during adolescence: a unique target of ethanol effects.

Journal Article Ann N Y Acad Sci · June 2004 Behaviors mediated by the hippocampus have long been known to be sensitive to the acute, chronic, and prenatal effects of ethanol. It has recently become clear that hippocampal function is uniquely responsive to ethanol during periadolescent development, a ... Full text Link to item Cite

The adolescent brain: Unique sensitivities and insensitivies to ethanol

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · May 1, 2004 Link to item Cite

Dietary prenatal choline supplementation alters postnatal hippocampal structure and function.

Journal Article J Neurophysiol · April 2004 Choline, a compound present in many foods, has recently been classified as an essential nutrient for humans. Studies with animal models indicate that the availability of choline during the prenatal period influences neural and cognitive development. Specif ... Full text Link to item Cite

Predictors of relapse during treatment and treatment completion among marijuana-dependent adolescents in an intensive outpatient substance abuse program.

Journal Article Subst Abus · March 2004 The present study assessed possible predictors of relapse while in treatment and treatment completion among marijuana-dependent adolescents (N = 59) in an intensive outpatient substance abuse treatment program. Comorbid depression was associated with an in ... Full text Link to item Cite

Suppression of Hippocampal Epileptiform Activity in Vitro after Laser Exposure

Journal Article Laser Therapy · January 1, 2004 Extracellular field potentials were recorded in the stratum pyramidale of CA3 in hippocampal slices prepared from male Sprague-Dawley rats. Electrical stimuli were delivered to s. radiatum of CA3. After stable responses were established, stimulus trains we ... Full text Cite

Experiential aspects of alcohol-induced blackouts among college students.

Journal Article Am J Drug Alcohol Abuse · 2004 Our current understanding of alcohol-induced memory blackouts is derived largely from research with middle-aged, hospitalized, male alcoholics. In the present study, 50 undergraduate students (34 female and 16 male) with a history of at least one blackout ... Full text Link to item Cite

Developmental differences in the sensitivity of hippocampal GABAA receptor-mediated IPSCS to ethanol.

Journal Article Alcohol Clin Exp Res · December 2003 BACKGROUND: Ethanol consumption by juveniles and adolescents is a public health problem of massive proportions. Recent studies have indicated that adolescents may be less sedated by ethanol than adults, and may thus be able to consume more ethanol, putting ... Full text Link to item Cite

Do college students drink more than they think? Use of a free-pour paradigm to determine how college students define standard drinks.

Journal Article Alcohol Clin Exp Res · November 2003 RATIONALE: Much of what is known about college drinking comes from self-report survey data. Such surveys typically ask students to indicate how many drinks they consume within a given period of time. It is currently unclear whether college students and res ... Full text Link to item Cite

Adolescent-onset nicotine self-administration modeled in female rats.

Journal Article Psychopharmacology (Berl) · September 2003 RATIONALE: Although the great majority of tobacco addiction begins during adolescence, little is known about differential nicotine effects in adolescents versus adults. OBJECTIVES: A rat model was used to determine the impact of the age of onset on nicotin ... Full text Link to item Cite

Performance of recently detoxified patients with alcoholism on a neuropsychological screening test.

Journal Article Addict Behav · July 2003 OBJECTIVE: Early in recovery from alcoholism, cognitive deficits may compromise patients' utilization of rehabilitative information. Cognitive impairment in a sample of newly detoxified inpatients with alcoholism was examined using the Neurobehavioral Cogn ... Full text Link to item Cite

Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat.

Journal Article Neurosci Lett · May 1, 2003 The availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a six-day gestational period protects against neurodegeneration in the posterior cingulate and retrosplen ... Full text Link to item Cite

Prevalence and correlates of alcohol-induced blackouts among college students: results of an e-mail survey.

Journal Article J Am Coll Health · November 2002 The authors conducted an e-mail survey of 772 college students to learn more about their experiences with blackouts. Approximately half (51%) of those who had ever consumed alcohol reported they had experienced a blackout at some point in their lives, and ... Full text Link to item Cite

Differential effects of ethanol on motor coordination in adolescent and adult rats.

Journal Article Pharmacol Biochem Behav · October 2002 Recent evidence suggests that adolescence represents a unique period of sensitivity to the effects of ethanol. Adolescent animals are more sensitive than adults to many of the effects of ethanol, including ethanol-induced learning and memory impairments, w ... Full text Link to item Cite

Chronic-intermittent ethanol exposure during adolescence prevents normal developmental changes in sensitivity to ethanol-induced motor impairments.

Journal Article Alcohol Clin Exp Res · July 2002 BACKGROUND: Recent evidence indicates that adolescent and adult rats are differentially sensitive to many of the acute effects of ethanol. Little is known about the neurobehavioral consequences of repeated ethanol exposure during adolescence relative to ad ... Full text Link to item Cite

Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats.

Journal Article Pharmacol Biochem Behav · June 2002 Impairments of learning and memory are common neuropsychological sequelae of chronic alcohol abuse. Alcoholics often have impairments of anterograde memory, including spatial memory dysfunction, and a tendency toward response perseveration. This study was ... Full text Link to item Cite

Differential effect of ethanol on NMDA EPSCs in pyramidal cells in the posterior cingulate cortex of juvenile and adult rats.

Journal Article J Neurophysiol · February 2002 Ethanol (EtOH) is a potent inhibitor of N-methyl-D-aspartate (NMDA) receptor-mediated activity in a number of brain areas, and recent studies have indicated that this inhibitory effect of ethanol is more powerful in the juvenile brain compared with the adu ... Full text Link to item Cite

Prenatal choline supplementation protects against postnatal neurotoxicity.

Journal Article J Neurosci · January 1, 2002 Choline, a dietary compound present in many foods, has recently been classified as an essential nutrient for humans. There is evidence from animal models that the availability of choline during the prenatal period influences neural and cognitive developmen ... Full text Link to item Cite

Age-independent and dose-response effects of ethanol on spatial memory in rats.

Journal Article Alcohol · April 2001 Results of previous studies have shown that ethanol impairs the acquisition of spatial memory in adolescent rats at doses below those required to impair the acquisition in adults. However, the previous work did not identify doses of ethanol that failed to ... Full text Link to item Cite

Age-related differences in neurosteroid potentiation of muscimol-stimulated 36Cl(-) flux following chronic ethanol treatment.

Journal Article Neuroscience · 2001 Alcoholism and alcohol abuse create costly social and economic problems in many nations. Recent studies indicate that alcohol exposure during adolescence may convey unique risks for subsequent neurocognitive deficits and problem drinking. Although GABA(A) ... Full text Link to item Cite

Prenatal choline supplementation alters hippocampal N-methyl-D-aspartate receptor-mediated neurotransmission in adult rats.

Journal Article Neurosci Lett · December 22, 2000 Manipulation of dietary choline levels in pregnant rats has been shown to result in enduring alterations in memory and hippocampal function of the offspring, but the mechanisms underlying these effects remain unclear. Hippocampal slices were prepared from ... Full text Link to item Cite

Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood.

Journal Article Brain Res Dev Brain Res · September 30, 2000 Manipulation of dietary choline levels during gestation results in enduring neurobehavioral changes in offspring that last into adulthood. Alterations of hippocampal function and memory are among the most striking changes. Depending upon the measures asses ... Full text Link to item Cite

Binge pattern ethanol exposure in adolescent and adult rats: differential impact on subsequent responsiveness to ethanol.

Journal Article Alcohol Clin Exp Res · August 2000 BACKGROUND: Recent evidence indicates that adolescent animals are more sensitive than adults to the disruptive effects of acute ethanol exposure on spatial learning. It is not yet known whether adolescent animals are also more sensitive than adults to the ... Link to item Cite

Thomas Joseph Walsh - 1953-2000 - In memoriam

Journal Article NEUROTOXICOLOGY · June 1, 2000 Link to item Cite

Neurotoxicity of ethyl methacrylate in rats.

Journal Article J Toxicol Environ Health A · January 28, 2000 Ethyl methacrylate (ethyl 2-methyl-2-propenoate, EMA) has been implicated in the development of neurologic impairment following occupational exposure. The potential of EMA to produce neurotoxicity was investigated in adult male Sprague-Dawley rats in two e ... Full text Link to item Cite

Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation.

Journal Article Brain Res Dev Brain Res · December 10, 1999 Supplementation with choline during pregnancy in rats causes a long-lasting improvement of visuospatial memory of the offspring. To determine if the behavioral effects of choline are related to physiological changes in hippocampus, the effect of perinatal ... Full text Link to item Cite

Age and dose-dependent effects of ethanol on the induction of hippocampal long-term potentiation.

Journal Article Alcohol · October 1999 Hippocampal long-term potentiation (LTP) is strongly associated with the acquisition of spatial memory and is attenuated by ethanol. Recent studies have shown that the inhibitory potency of ethanol against n-methyl-d-aspartate (NMDA) receptor-mediated syna ... Full text Link to item Cite

Developmental changes in seizure susceptibility during ethanol withdrawal.

Journal Article Alcohol · May 1999 It has recently been established that adolescence may represent a developmentally sensitive period with respect to the effects of ethanol, particularly within the NMDA neurotransmitter system. However, the same may also be true of the GABA system. There is ... Full text Link to item Cite

Impairment of semantic and figural memory by acute ethanol: age-dependent effects.

Journal Article Alcohol Clin Exp Res · October 1998 Alcohol drinking is prevalent among young adults in the U.S. Moreover, heavy drinking is acknowledged by a substantial percentage of young adults in both college and military subpopulations, despite the known cognitive demands associated with these endeavo ... Full text Link to item Cite

Developmental differences in the acquisition of tolerance to ethanol.

Journal Article Alcohol · May 1998 This study was designed to compare the development of tolerance to ethanol in adolescent and adult rats. Rats were pretreated with ethanol (4 g/kg) twice daily by intragastric gavage for 3 or 7 days, and then challenged with a single IP dose of ethanol (5 ... Full text Link to item Cite

Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats.

Journal Article J Neurophysiol · April 1998 Choline supplementation during gestation in rats leads to augmentation of spatial memory in adulthood. We hypothesized that prenatal (E12-E17) choline supplementation in the rat would lead to an enhancement of hippocampal synaptic plasticity as assessed by ... Full text Link to item Cite

Differential effects of ethanol on memory in adolescent and adult rats.

Journal Article Alcohol Clin Exp Res · April 1998 Previous studies have shown that ethanol inhibits memory-related synaptic activity and plasticity more potently in hippocampal slices from immature rats, compared with those taken from adults. We therefore hypothesized that ethanol would more potently atte ... Link to item Cite

Differential effects of ethanol in adolescent and adult rats.

Journal Article Alcohol Clin Exp Res · November 1996 Alcohol use in children and adolescents is widespread. However, very little is known about the effects of alcohol exposure during this period of postnatal development. The goal of the present study was to compare the relative sensitivity to the sedative ef ... Full text Link to item Cite

Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade.

Journal Article Neuroscience · September 1996 This series of experiments assessed the role of GABAB receptors in the induction of long-term potentiation in the dentate gyrus in vivo, and spatial learning and memory in three different tasks. In urethane-anesthetized rats, the GABAB receptor antagonist ... Full text Link to item Cite

Medial septal benzodiazepine receptors modulate hippocampal evoked responses and long-term potentiation.

Journal Article Brain Res · April 22, 1996 Infusion of benzodiazepine (BDZ) receptor ligands into the medial septum (MS) produces a bidirectional modulation of spatial memory retention. The present experiments sought to determine the effects of BDZ ligands upon synaptic responses and long-term pote ... Full text Link to item Cite

Outcome of temporal lobectomy in adolescents

Journal Article Journal of Epilepsy · January 1, 1996 We performed temporal lobectomy in 23 young patients with intractable complex partial seizures (CPS) at an average age of 14.5 years. At a mean follow-up interval of 4.8 years, we reevaluated the patients to assess the surgical outcome; 74% were seizure-fr ... Full text Cite

Age-dependent inhibition of long-term potentiation by ethanol in immature versus mature hippocampus.

Journal Article Alcohol Clin Exp Res · December 1995 The goal of this study was to assess the effects of ethanol on the induction of long-term potentiation (LTP) in hippocampal slices from immature versus mature rats. Population excitatory postsynaptic potentials (pEPSPs) were recorded from stratum radiatum ... Full text Link to item Cite

Ethanol inhibition of AMPA and kainate receptor-mediated depolarizations of hippocampal area CA1.

Journal Article Alcohol Clin Exp Res · October 1995 Longitudinal hippocampal slices were prepared from adult female rats. The excitatory amino acids, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and kainic acid, were applied to area CA1, and the resulting depolarizations were measured using ... Full text Link to item Cite

GABAB receptors modulate synaptically-evoked responses in the rat dentate gyrus, in vivo.

Journal Article Brain Res · April 24, 1995 We assessed the effects of systemically injected baclofen, a GABAB agonist, on single and paired-pulse responses in the dentate gyrus of urethane-anesthetized rats, in vivo. Baclofen (10 mg/kg) significantly increased the duration of single excitatory resp ... Full text Link to item Cite

Differential sensitivity of NMDA receptor-mediated synaptic potentials to ethanol in immature versus mature hippocampus.

Journal Article Alcohol Clin Exp Res · April 1995 Pharmacologically isolated, NMDA receptor-mediated population EPSPs (pEPSPs) were evoked from area CA1 of hippocampal slices using electrical stimulation of the Schaffer collateral/commissural fiber pathway. Slices were prepared from rats aged 20-25 or 80- ... Full text Link to item Cite

Intracerebroventricular nicotine and mecamylamine alter radial‐arm maze performance in rats

Journal Article Drug Development Research · January 1, 1994 In rats, the effects of an intracerebroventricular (ICV) nicotinic agonist nicotine (NIC), the nicotinic antagonist mecamylamine (MEC), and combinations of NIC + MEC were assessed in a radial‐arm maze (RAM). In experiment 1, exploratory behavior was assess ... Full text Cite

Attenuation of hippocampal long-term potentiation by ethanol: a patch-clamp analysis of glutamatergic and GABAergic mechanisms.

Journal Article J Neurosci · May 1993 Long-term potentiation of synpatic transmission (LTP) of the perforant path--dentate gyrus synapse is induced by 5 Hz, theta-like stimulation patterns. Such stimuli induce plasticity that is most likely driven by a decrease in synaptic inhibition (disinhib ... Full text Link to item Cite

GABAB autoreceptors mediate activity-dependent disinhibition and enhance signal transmission in the dentate gyrus.

Journal Article J Neurophysiol · March 1993 1. Activity-dependent depression (fading) of polysynaptic inhibition and the effects of this disinhibition on signal transmission were studied in the dentate gyrus of the rat hippocampal slice with the use of intracellular and extracellular recordings. 2. ... Full text Link to item Cite

Proconvulsant and anticonvulsant properties of ethanol: studies of electrographic seizures in vitro.

Journal Article Brain Res · January 22, 1993 Recent studies have demonstrated that ethanol is a potent blocker of N-methyl-D-aspartate (NMDA) receptor mediated responses. It is well known that neuroplasticity processes depend on the activation of the NMDA type of excitatory amino acid receptor. We ha ... Full text Link to item Cite

Antiepileptic effects of GABAb receptor activation in area CA3 of rat hippocampus.

Journal Article Brain Res · January 15, 1993 The role of GABAb receptor activation in the expression of both interictal and ictal phenomena was investigated in slices of area CA3 of the rat hippocampal formation. Interictal-like bursts occurred following application of high frequency trains to the Sc ... Full text Link to item Cite

Ethanol inhibits release of excitatory amino acids from slices of hippocampal area CA1.

Journal Article Eur J Pharmacol · September 4, 1992 Slices of hippocampal area CA1 were employed to test the hypothesis that release of excitatory amino acids glutamate and aspartate is regulated by ethanol. K(+)-evoked release of glutamate and aspartate was inhibited by ethanol (25-100 mM) in a dose-depend ... Full text Link to item Cite

The GABAB receptor antagonist, CGP-35348, inhibits paired-pulse disinhibition in the rat dentate gyrus in vivo.

Journal Article Brain Res · August 14, 1992 Extracellular field potentials were recorded from the dentate gyrus of adult rats during electrical stimulation of the angular bundle in vivo. Paired pulses produced inhibition of the second population spike (PS2) at 25 ms, and potentiation at inter-stimul ... Full text Link to item Cite

Effects of prenatal ethanol exposure on hippocampal ionotropic-quisqualate and kainate receptors.

Journal Article Alcohol Clin Exp Res · August 1992 Previous studies from our laboratories have shown that the consumption of moderate quantities of ethanol by rat dams during pregnancy reduces N-methyl-D-aspartate (NMDA) agonist receptor binding and NMDA-mediated electrophysiological responses in the hippo ... Full text Link to item Cite

THE PHYSIOLOGICAL SIGNIFICANCE OF GABA-B RECEPTOR-MEDIATED DISINHIBITION IN THE DENTATE GYRUS

Conference PHARMACOLOGY COMMUNICATIONS, VOL 2, NOS 1 AND 2 · January 1, 1992 Link to item Cite

Ethanol and magnesium ions inhibit N-methyl-D-aspartate-mediated synaptic potentials in an interactive manner.

Journal Article Neuropharmacology · November 1991 The role of magnesium ions in the inhibitory effect of ethanol on NMDA receptor-mediated population synaptic potentials (pEPSPs) in area CA1 of the hippocampus of the adult rat, was studied. The excitatory amino acid (non-NMDA) receptor antagonist, DNQX an ... Full text Link to item Cite

Ethanol inhibition of NMDA mediated depolarizations is increased in the presence of Mg2+.

Journal Article Brain Res · April 19, 1991 The inhibitory potency of ethanol upon excitatory amino acid induced depolarizations of rat hippocampal CA1 pyramidal cells was assessed in the presence and absence of magnesium (Mg2+) using the grease-gap technique. Ethanol shifted the N-methyl-D-aspartat ... Full text Link to item Cite

GABAB-receptor-mediated inhibition of the N-methyl-D-aspartate component of synaptic transmission in the rat hippocampus.

Journal Article J Neurosci · January 1991 GABA receptor regulation of NMDA-receptor-mediated synaptic responses was studied in area CA1 of the rat hippocampus using extracellular and intracellular recording techniques. Picrotoxin (PTX) was used to suppress GABAA inhibition and 6,7-dinitroquinoxali ... Full text Link to item Cite

Regenerative, all-or-none electrographic seizures in the rat hippocampal slice in Mg-free and physiological medium.

Journal Article Brain Res · November 5, 1990 All-or-none electrographic seizures (EGSs) were studied in hippocampal slices from young (21- to 38-day-old) rats in medium containing low (0 mM) or physiological (0.9 mM) levels of magnesium, with and without the GABAB agonist baclofen. Extracellular reco ... Full text Link to item Cite

Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats.

Journal Article Brain Res Dev Brain Res · November 1, 1990 This study describes the measurement of N-methyl-D-aspartate (NMDA)-mediated excitatory postsynaptic potentials (EPSPs) of the CA1 subregion of transverse hippocampal slices from immature and adult rats. Our methods permit extracellular measurement of NMDA ... Full text Link to item Cite

Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus.

Journal Article Neurosci Lett · May 31, 1990 The effect of baclofen on the development of long-term potentiation (LTP) in the dentate gyrus was examined. Stimulus trains applied to the perforant path in the presence of baclofen produced significantly more potentiation of the perforant path-evoked res ... Full text Link to item Cite

MK-801 potently inhibits alcohol withdrawal seizures in rats.

Journal Article Eur J Pharmacol · January 25, 1990 The ability of MK-801, an N-methyl-D-aspartate (NMDA)-channel antagonist, to suppress alcohol withdrawal seizures generated audio-genically was studied in adult male rats using a cross-over experimental design. MK-801 treatment reduced overall seizure scor ... Full text Link to item Cite

The drug MK-801 attenuates the development, but not the expression, of long-term potentiation and stimulus train-induced bursting in hippocampal slices.

Journal Article Neuropharmacology · May 1989 Recent studies have demonstrated that (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), a use-dependent blocker of N-methyl-D-aspartate (NMDA)-activated membrane channels, attenuates the development of long-term potentiation in vit ... Full text Link to item Cite

The effects of baclofen and pertussis toxin on epileptiform activity induced in the hippocampal slice by magnesium depletion.

Journal Article Epilepsy Res · 1989 Bathing hippocampal slices in artificial cerebrospinal fluid without magnesium elicits repetitive, long ictal-like discharges termed ictaform events. The ictaform events are separated by interictal periods that are initially silent with no interictal burst ... Full text Link to item Cite

Suppression of hippocampal epileptiform activity in vitro after laser exposure

Journal Article LASER THERAPY · January 1, 1989 Extracellular field potentials were recorded in stratum pyramidate of CA3 in hippocampal slices prepared from male Sprague-Dawley rats. Electrical stimuli were delivered lo s. radiatum of CA3. After stable responses were established, stimulus trains were d ... Full text Cite

Prenatal exposure to ethanol decreases the sensitivity of the adult rat hippocampus to N-methyl-D-aspartate.

Journal Article Alcohol · 1989 Morphological, neurochemical, and electrophysiological studies suggest that the hippocampal formation is one of the brain regions most sensitive to the teratological consequences of prenatal exposure to ethanol. We now report that prenatal ethanol exposure ... Full text Link to item Cite

Tetrahydropapaveroline and salsolinol alter 45Ca2+ efflux within perfused hippocampus of unrestrained rats.

Journal Article Neurochem Res · October 1988 The kinetics of 45Ca2+ efflux were examined at circumscribed sites in the perfused hippocampus of the freely moving rat with either one of two tetrahydroisoquinoline (TIQ) products, tetrahydropapaveroline (THP) or salsolinol. Guide tubes for unilateral pus ... Full text Link to item Cite

Seizure activity in vitro: a dual focus model.

Journal Article Epilepsy Res · 1988 Recently, we have reported that the exposure of hippocampal slices in vitro to artificial cerebrospinal fluid (ACSF) containing no added magnesium results in ictal-like (ictaform) activity in area CA3 of the hippocampal formation. Other reports describe su ... Full text Link to item Cite

Prenatal exposure to ethanol decreases physiological plasticity in the hippocampus of the adult rat.

Journal Article Alcohol · 1988 Prenatal exposure to ethanol has been associated with birth defects ranging in severity from physical dysmorphias and profound mental retardation to more subtle compromises of cognitive and behavioral function. Recent evidence has shown the hippocampus to ... Full text Link to item Cite

Mechanism of electrographic seizure generation in the hippocampal slice in Mg2+-free medium: the role of GABAa inhibition.

Journal Article Epilepsy Res · 1988 We recently have described a new model of ictal-like electrographic activity in the hippocampal slice. When magnesium is eliminated from the medium bathing the hippocampal slice, spontaneously occurring electrical events which closely resemble electrograph ... Full text Link to item Cite

Potential interactions between GABAb and cholinergic systems: baclofen augments scopolamine-induced performance deficits in the eight-arm radial maze.

Journal Article Psychopharmacology (Berl) · 1988 Sixteen male Fischer-344N rats were trained on a eight-arm radial maze task for food reinforcement. The effects of various doses of baclofen (1.25 or 2.50 mg/kg) and scopolamine (0.188, 0.375, and 0.750 mg/kg) were determined alone and in combination. Rela ... Full text Link to item Cite

Seizure-like events in brain slices: suppression by interictal activity.

Journal Article Brain Res · May 5, 1987 A major concern in epilepsy research is the relationship between ictal (seizure) electrophysiological activity and interictal (between seizure) activity. Much research is carried out in vitro using brain slice models. Although they allow detailed electroph ... Full text Link to item Cite

Differential effects of phenobarbital and pentobarbital on stimulus train-induced bursting in the hippocampal slice.

Journal Article Epilepsia · 1987 Stimulus train-induced bursting (STIB) in the hippocampal slice is an in vitro model of epileptiform activity that is analogous to kindling and requires no manipulation of the neurochemical or ionic environment. The bursts recorded from slices after STIB c ... Full text Link to item Cite

Baclofen disrupts passive avoidance retention in rats.

Journal Article Psychopharmacology (Berl) · 1987 Baclofen (Lioresal, Ciba-Geigy) is an analog of the inhibitory neurotransmitter GABA and is used clinically to control spasticity. Recent studies have demonstrated that this compound produces a marked inhibition of synaptically evoked responses in area CA3 ... Full text Link to item Cite

The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice.

Journal Article J Neurophysiol · January 1987 The role of N-methyl-D-aspartate (NMDA) receptors in producing stimulus train-induced bursting (STIB) was examined in area CA3 of the rat hippocampus. Extracellular recordings were made from the CA3 pyramidal cell layer. Bursting was induced by trains of e ... Full text Link to item Cite

Attenuation of epileptiform bursting by baclofen: reduced potency in elevated potassium.

Journal Article Exp Neurol · December 1986 Baclofen is an analog of the inhibitory neurotransmitter, GABA, which is used clinically to control spasticity. Recent evidence has accumulated showing this compound to have profound inhibitory effects upon hippocampal neural activity at both the cellular ... Full text Link to item Cite

Magnesium-free medium activates seizure-like events in the rat hippocampal slice.

Journal Article Brain Res · November 19, 1986 The effect of magnesium-free medium on the electrical activity in CA3 of the rat hippocampal slice was examined. Magnesium removal resulted in the development of spontaneous and triggered interictal-like bursting, followed by spontaneous ictal-like events ... Full text Link to item Cite

CCK and other peptides modulate hypothalamic norepinephrine release in the rat: dependence on hunger or satiety.

Journal Article Brain Res Bull · October 1986 The purpose of this investigation was to determine the functional relationship between putative satiety peptides and endogenous norepinephrine (NE) activity in the hypothalamus. Permanent guide cannulae for push-pull perfusion were implanted stereotaxicall ... Full text Link to item Cite

Baclofen suppresses hippocampal epileptiform activity at low concentrations without suppressing synaptic transmission.

Journal Article J Pharmacol Exp Ther · June 1986 Baclofen is used clinically to treat spasticity, but has received little attention as a potential antiepileptic agent. To explore the antiepileptic potential of baclofen further, we tested its effect on stimulus train-induced bursting, an in vitro model of ... Link to item Cite

Central neurotoxicity after exposure to organic lead: susceptibility to seizures.

Journal Article Neurosci Lett · July 31, 1985 Organic leads are present in the environment from a variety of sources and produce metabolites such as triethyl lead (TEL) which have relatively long half-lives in the brain. However, little is known at present about the possible neurological consequences ... Full text Link to item Cite

Alterations in regulatory and locomotor behaviors following trimethyltin exposure in the rat: a time and dose analysis.

Journal Article Neurosci Lett · June 15, 1984 Adult male hooded rats were tested pretreatment for spontaneous alternation and open-field behaviors. Animals were then intubated with either 5 or 7 mg/kg trimethyltin chloride (TMT Cl) or the isotonic saline vehicle. Post-treatment, animals were again tes ... Full text Link to item Cite

Disruption of learned and spontaneous alternation in the rat by trimethyltin: chronic effects.

Journal Article Neurobehav Toxicol Teratol · 1984 Trimethyltin (TMT) is a known neurotoxin which produces behavioral anomalies including hyperactivity, aggressiveness, perseveration, and learning deficits. These dysfunctions appear to be related to a severe loss of neurons in the hippocampal formation of ... Link to item Cite

Altered responsiveness to alcohol after exposure to organic lead.

Journal Article Alcohol · 1984 Ethyl alcohol is known to effect the functional integrity of the limbic system, particularly the hippocampus, and to alter behaviors which are thought to be mediated through limbic function. Organometals also compromise the limbic system and result in defi ... Full text Link to item Cite

Antagonism by d-amphetamine of trimethyltin-induced hyperactivity evidence toward an animal model of hyperkinetic behavior.

Journal Article Neuropharmacology · September 1983 In male rats of the Long-Evans strain, either 7.0 mg/kg of trimethyltin (TMT) or 0.9% NaCl was administered by intragastric gavage. After a period of recovery from the typical signs of trimethyltin toxicity, each rat was tested at 72-hr intervals for its l ... Full text Link to item Cite

Kainic acid lesioning of alkaloid-sensitive brain sites and ethanol ingestion in the rat.

Journal Article Neurosci Lett · March 28, 1983 A control alcohol (ethanol) preference test was first given to adult male Sprague-Dawley rats which were provided water together with alcohol increased in concentrations from 3 to 30% over 8 days. Then each rat was anesthetized and a two-stage, bilateral l ... Full text Link to item Cite

Effect of hippocampal lesions produced by intracerebroventricular kainic acid on alcohol drinking in the rat.

Journal Article Brain Res Bull · March 1983 An alcohol self-selection test was first given to adult male rats of either the Sprague-Dawley or Long-Evans strain in which the concentrations available with water were increased from 3% to 30% over an eight-day period. Subsequently, the animals were anes ... Full text Link to item Cite

DIFFERENTIAL RELEASE OF CA++ IONS FROM THE HIPPOCAMPUS OF THE RAT INDUCED BY ALCOHOLS AND ACETALDEHYDE

Journal Article ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · January 1, 1983 Link to item Cite

DIFFERENTIAL RELEASE OF CA++ IONS FROM THE HIPPOCAMPUS OF THE RAT INDUCED BY ALCOHOLS AND ACETALDEHYDE

Journal Article ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · January 1, 1983 Link to item Cite

Imparied maze performance in the rat caused by trimethyltin treatment: problem-solving deficits and perseveration.

Journal Article Neurobehavioral toxicology and teratology · March 1982 Trimethyltin (TMT) produces cytological damage to several limbic-forebrain structures which is accompanied by behavioral changes including hyperactivity and aggressiveness. The purpose of this investigation was to determine whether the problem-solving capa ... Cite

Acute treatment with trimethyltin alters alcohol self-selection.

Journal Article Psychopharmacology (Berl) · 1982 Male rats of the Long-Evans strain were divided into two equal groups of nine each and given either 7.0 mg/kg trimethyltin (TMT) or 0.9% saline by intragastric gavage. The pattern of self-selection of alcohol in concentrations of 3%--30% was examined in bo ... Full text Link to item Cite

Imparied maze performance in the rat caused by trimethyltin treatment: problem-solving deficits and perseveration.

Journal Article Neurobehav Toxicol Teratol · 1982 Trimethyltin (TMT) produces cytological damage to several limbic-forebrain structures which is accompanied by behavioral changes including hyperactivity and aggressiveness. The purpose of this investigation was to determine whether the problem-solving capa ... Link to item Cite

NEONATAL TREATMENT WITH TETRAHYDROISOQUINOLINES ALTERS ALCOHOL DRINKING IN THE ADULT-RAT

Journal Article ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · January 1, 1982 Link to item Cite

NEUROTOXICOLOGY OF THE ALKYLTINS - INTRODUCTION

Journal Article NEUROBEHAVIORAL TOXICOLOGY AND TERATOLOGY · January 1, 1982 Link to item Cite

Activity changes in rats following acute trimethyltin exposure.

Journal Article Neurotoxicology · November 1981 The aliphatic organo-metal derivative, trimethyltin, causes marked morphological damage to the central nervous system (CNS), when the compound is administered by the intragastric route. This report describes certain behavioral consequences of [CH3]3Sn trea ... Link to item Cite

Glutaminergic neuron lesions in the brain of the rat: Effects on alcohol drinking

Journal Article Alcoholism: Clinical and Experimental Research · January 1, 1981 Cite

Alterations in alcohol intake in the rat by inhibition of amine-aldehyde condensation or amino acid treatment

Journal Article Alcoholism: Clinical and Experimental Research · January 1, 1981 Cite

Trimethyl-tin reduces home cage and schedule-induced alcohol self-selection

Journal Article Alcoholism: Clinical and Experimental Research · January 1, 1981 Cite

INHIBITION OF AMINE-ALDEHYDE CONDENSATION-REACTIONS ANTAGONIZES VOLUNTARY ALCOHOL-CONSUMPTION

Journal Article ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · January 1, 1981 Link to item Cite

GLUTAMINERGIC NEURON LESIONS IN THE BRAIN OF THE RAT - EFFECTS ON ALCOHOL DRINKING

Journal Article ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · January 1, 1981 Link to item Cite

TRIMETHYL-TIN REDUCES HOME CAGE AND SCHEDULE-INDUCED ALCOHOL SELF-SELECTION

Journal Article ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · January 1, 1981 Link to item Cite

ALTERATIONS IN ALCOHOL INTAKE IN THE RAT BY INHIBITION OF AMINE-ALDEHYDE CONDENSATION OR AMINO-ACID TREATMENT

Journal Article ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · January 1, 1981 Link to item Cite

The operant assessment of taste discrimination.

Journal Article Behav Neural Biol · November 1980 Full text Link to item Cite

Differences in afterdischarge threshold determination methods: implications for experimental designs.

Journal Article Neurobehav Toxicol · 1980 Hippocampal afterdischarge (AD) thresholds were determined twice using different threshold determination methods. Fourty-five days later thresholds were redetermined using each of the methods. Method A [3] produced higher AD thresholds which were less stab ... Link to item Cite

Depressed excitability and integrated EEGs following hippocampal afterdischarges.

Journal Article Brain Res Bull · 1980 Rats with chronic hippocampal electrode implants had afterdischarges induced with electrical stimulus intensities of 115, 200, and 800% of a previously determined threshold. Afterdischarge duration, postictal EEG depression duration, and the duration of po ... Full text Link to item Cite

Prenatal carbon monoxide and adult evoked potentials in rats

Journal Article Journal of Environmental Science and Health Part C Environmental Health Sciences · December 1, 1979 Cite

Alterations in neurotransmitter activity after acute and chronic ethanol treatment: studies of transmitter interactions.

Journal Article Alcohol Clin Exp Res · October 1979 Acute and chronic ethanol treatment has multiple effects on the neurotransmitter systems in the nigrostriatal complex. A single dose of ethanol increases striatal dopamine release at low doses, but depresses it at high doses. In ethanol-dependent rats, dop ... Full text Link to item Cite

Hippocampal afterdischarges and their post-ictal sequelae in rats: a potential tool for assessment of CNS neurotoxicity.

Journal Article Neurobehav Toxicol · 1979 Two types of AD and post-AD sequences are described. Type 1, which were most common (83%), are followed by a profound post-ictal depression (PID). PIDs can be quantitatively measured by integrating the EEG. The post-ictal EEG power normally returned to 75% ... Link to item Cite

Alcohol-induced alterations in hippocampal afterdischarges and afterdischarge thresholds: dose-reponse studies.

Journal Article Neurobehav Toxicol · 1979 The hippocampal afterdischarge (AD) has been suggested as an index of toxicant-induced CNS change [1]. The present experiments report raised AD thresholds, decreased AD durations, shorter post-stimulation latencies to AD onset, decreased numbers of AD spik ... Link to item Cite

Prenatal carbon monoxide and adult evoked potentials in rats.

Journal Article J Environ Sci Health C · 1979 Hooded rats prenatally exposed to mild carbon monoxide hypoxia were studied as adults. Flash evoked potentials were recorded from the visual cortex of unanesthetized exposed and control rats at four different flash intensities. The amplitude of bothe the P ... Link to item Cite

Hippocampal afterdischarges and their post-ictal sequelae in rats: effects of carbon monoxide hypoxia.

Journal Article Neurobehav Toxicol · 1979 A series of experiments was performed to examine the utility of using the properties of artifically induced seizures as indices of the toxic effect of CO upon the CNS. The two behavioral seizure models tested, 6 Hz ECS and pentylenetetrazol, were unable to ... Link to item Cite

NEUROTRANSMITTER-RECEPTOR BINDING IN VARIOUS BRAIN-REGIONS IN ETHANOL-DEPENDENT RATS

Journal Article ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · January 1, 1979 Link to item Cite

Sex and strain differences in the visual evoked potentials of albino and hooded rats.

Journal Article Pharmacol Biochem Behav · September 1978 Visually evoked potentials were recorded n male and female rats from albino and hooded strains. Recordings were made at 4 different flash intensities in unanesthetized animals. Clear sex and strain differences were observed. Females had larger amplitude P1 ... Full text Link to item Cite