Scholars@Duke
Claude Anthony Piantadosi

Claude Anthony Piantadosi

Professor Emeritus of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
piant001@mc.duke.edu
Duke Box 3315, Durham, NC 27710
0570 Clin Res II, Durham, NC 27710

Selected Publications

Carbon monoxide and mitochondria

Chapter · May 13, 2022 Carbon monoxide (CO) is capable of binding to some proteins containing other transition metals at their active sites, for instance, cobalt, nickel, and copper, thereby interfering with their functions. This chapter provides a summary of the biochemistry of ... Full text Cite

Nuclear respiratory factor-1 negatively regulates TGF-β1 and attenuates pulmonary fibrosis.

Journal Article iScience · January 21, 2022 The preclinical model of bleomycin-induced lung fibrosis is useful to study mechanisms related to human pulmonary fibrosis. Using BLM in mice, we find low HO-1 expression. Although a unique Rhenium-CO-releasing molecule (ReCORM) up-regulates HO-1, NRF-1, C ... Full text Link to item Cite

Erratum: Skeletal muscle mitochondrial fragmentation and impaired bioenergetics from nutrient overload are prevented by carbon monoxide (American Journal of Physiology - Cell Physiology (2020) 319 (C746-C756) DOI: 10.1152/ajpcell.00016.2020)

Journal Article American Journal of Physiology - Cell Physiology · December 1, 2020 Skeletal muscle mitochondrial fragmentation and impaired bioenergetics from nutrient overload are prevented by carbon monoxide. Am J Physiol Cell Physiol 319: C746–C756, 2020. First published August 26, 2020; https://doi.org/ 10.1152/ajpcell.00016.2020.—In ... Full text Cite

Skeletal muscle mitochondrial fragmentation and impaired bioenergetics from nutrient overload are prevented by carbon monoxide.

Journal Article Am J Physiol Cell Physiol · October 1, 2020 Nutrient excess increases skeletal muscle oxidant production and mitochondrial fragmentation that may result in impaired mitochondrial function, a hallmark of skeletal muscle insulin resistance. This led us to explore whether an endogenous gas molecule, ca ... Full text Open Access Link to item Cite

Mitochondrial DNA, oxidants, and innate immunity.

Journal Article Free Radic Biol Med · May 20, 2020 Mitochondrial oxidant damage, including damage to mitochondrial DNA (mtDNA) is a feature of both severe microbial infections and inflammation arising from sterile (non-infectious) sources such as tissue trauma. Damaged mitochondria release intact or oxidiz ... Full text Link to item Cite

Carbon Monoxide and Exercise Prevents Diet-Induced Obesity and Metabolic Dysregulation Without Affecting Bone.

Journal Article Obesity (Silver Spring) · May 2020 OBJECTIVE: Carbon monoxide (CO) may counteract obesity and metabolic dysfunction in rodents consuming high-fat diets, but the skeletal effects are not understood. This study investigated whether low-dose inhaled CO (250 ppm) with or without moderate intens ... Full text Open Access Link to item Cite

Nonclassical Monocytes Sense Hypoxia, Regulate Pulmonary Vascular Remodeling, and Promote Pulmonary Hypertension.

Journal Article J Immunol · March 15, 2020 An increasing body of evidence suggests that bone marrow-derived myeloid cells play a critical role in the pathophysiology of pulmonary hypertension (PH). However, the true requirement for myeloid cells in PH development has not been demonstrated, and a sp ... Full text Link to item Cite

Increased Antiseizure Effectiveness with Tiagabine Combined with Sodium Channel Antagonists in Mice Exposed to Hyperbaric Oxygen.

Journal Article Neurotox Res · November 2019 Hyperbaric oxygen (HBO2) is acutely toxic to the central nervous system, culminating in EEG spikes and tonic-clonic convulsions. GABA enhancers and sodium channel antagonists improve seizure latencies in HBO2 when administered individually, while combining ... Full text Open Access Link to item Cite

Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis.

Journal Article Crit Care Med · May 2019 OBJECTIVES: Metabolic derangements in sepsis stem from mitochondrial injury and contribute significantly to organ failure and mortality; however, little is known about mitochondrial recovery in human sepsis. We sought to test markers of mitochondrial injur ... Full text Link to item Cite

Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1.

Journal Article Circulation · March 26, 2019 BACKGROUND: Receptor signaling is central to vascular endothelial function and is dysregulated in vascular diseases such as atherosclerosis and pulmonary arterial hypertension (PAH). Signaling pathways involved in endothelial function include vascular endo ... Full text Link to item Cite

ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia.

Journal Article Proc Natl Acad Sci U S A · January 29, 2019 Current therapeutic interventions for the treatment of respiratory infections are hampered by the evolution of multidrug resistance in pathogens as well as the lack of effective cellular targets. Despite the identification of multiple region-specific lung ... Full text Link to item Cite

A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.

Journal Article JCI Insight · December 6, 2018 BACKGROUND: Acute respiratory distress syndrome (ARDS) is a prevalent disease with significant mortality for which no effective pharmacologic therapy exists. Low-dose inhaled carbon monoxide (iCO) confers cytoprotection in preclinical models of sepsis and ... Full text Link to item Cite

Pharmacologic Targeting of Red Blood Cells to Improve Tissue Oxygenation.

Journal Article Clin Pharmacol Ther · September 2018 Disruption of microvascular blood flow is a common cause of tissue hypoxia in disease, yet no therapies are available that directly target the microvasculature to improve tissue oxygenation. Red blood cells (RBCs) autoregulate blood flow through S-nitroso- ... Full text Open Access Link to item Cite

Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia.

Journal Article Clin Pharmacol Ther · May 2018 We hypothesized that concomitant pharmacological inhibition of the endothelin and adenosine pathway is safe and improves exercise performance in hypoxic humans, via a mechanism that does not involve augmentation of blood oxygenation. To test this hypothesi ... Full text Link to item Cite

RhoA inactivation by S-nitrosylation regulates vascular smooth muscle contractive signaling.

Journal Article Nitric Oxide · April 1, 2018 S-nitrosothiols derived from nitric oxide are known to regulate cell signaling through thiol modification. Since small G protein RhoA contains cysteine residues in the GTP-binding domain which is critical for its function, modification these thiols may alt ... Full text Link to item Cite

The release of microparticles and mitochondria from RAW 264.7 murine macrophage cells undergoing necroptotic cell death in vitro.

Journal Article Exp Cell Res · February 15, 2018 Microparticles (MPs) are small membrane-bound vesicles released from activated or dying cells. As shown previously, LPS stimulation of the RAW 264.7 macrophage cell line can induce MP release, with the caspase inhibitor Z-VAD increasing the extent of this ... Full text Link to item Cite

Mitochondrial quality control in alveolar epithelial cells damaged by S. aureus pneumonia in mice.

Journal Article Am J Physiol Lung Cell Mol Physiol · October 1, 2017 Mitochondrial damage is often overlooked in acute lung injury (ALI), yet most of the lung's physiological processes, such as airway tone, mucociliary clearance, ventilation-perfusion (Va/Q) matching, and immune surveillance require aerobic energy provision ... Full text Link to item Cite

The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans.

Journal Article Can J Physiol Pharmacol · September 2017 Hypoxemia can be life-threatening, both acutely and chronically. Because hypoxemia causes vascular dysregulation that further restricts oxygen availability to tissue, it can be pharmacologically addressed. We hypothesized that theophylline can be safely co ... Full text Link to item Cite

S-nitrosylation of GAD65 is implicated in decreased GAD activity and oxygen-induced seizures.

Journal Article Neurosci Lett · July 13, 2017 Breathing oxygen at partial pressures ≥2.5 atmospheres absolute, which can occur in diving and hyperbaric oxygen (HBO2) therapy, can rapidly become toxic to the central nervous system (CNS). This neurotoxicity culminates in generalized EEG epileptiform dis ... Full text Open Access Link to item Cite

Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction.

Journal Article Am J Respir Cell Mol Biol · March 2017 Oxidative stress resulting from inflammatory responses that occur during acute lung injury and sepsis can initiate changes in mitochondrial function. Autophagy regulates cellular processes in the setting of acute lung injury, sepsis, and oxidative stress b ... Full text Link to item Cite

Antiepileptic drugs prevent seizures in hyperbaric oxygen: A novel model of epileptiform activity.

Journal Article Brain Res · February 15, 2017 Breathing oxygen at sufficiently elevated pressures can trigger epileptiform seizures. Therefore, we tested the hypothesis that pre-treatment with FDA-approved antiepileptic drugs could prevent seizure onset in hyperoxia at 5 atmospheres absolute. We selec ... Full text Link to item Cite

Mitochondrial Dysfunction in Lung Pathogenesis.

Journal Article Annu Rev Physiol · February 10, 2017 Remarkable new roles for mitochondria in calcium handling, apoptosis, heme turnover, inflammation, and oxygen and nutrient sensing have been discovered for organelles that were once thought to be simple energy converters. Although deficits in mitochondrial ... Full text Link to item Cite

Mitochondrial quality-control dysregulation in conditional HO-1-/- mice.

Journal Article JCI Insight · February 9, 2017 The heme oxygenase-1 (Hmox1; HO-1) pathway was tested for defense of mitochondrial quality control in cardiomyocyte-specific Hmox1 KO mice (HO-1[CM]-/-) exposed to oxidative stress (100% O2). After 48 hours of exposure, these mice showed persistent cardiac ... Full text Link to item Cite

Cardioprotective role of S-nitrosylated hemoglobin from rbc.

Journal Article J Clin Invest · December 1, 2016 Nitric oxide (NO) is a potent mediator of blood vessel dilation and is released by several cell sources. Red blood cells (rbc) release NO when hemoglobin that has been S-nitrosylated at Cys93 of the β-chain (βCys93) transitions from the oxygenated form to ... Full text Link to item Cite

Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant.

Journal Article Clin Transplant · September 2016 BACKGROUND: Central airway stenosis (CAS) is common after lung transplantation and causes significant post-transplant morbidity. It is often preceded by extensive airway necrosis, related to airway ischemia. Hyperbaric oxygen therapy (HBOT) is useful for i ... Full text Link to item Cite

Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation.

Journal Article Am J Respir Crit Care Med · March 1, 2016 RATIONALE: Central airway stenosis (CAS) after lung transplantation has been attributed in part to chronic airway ischemia; however, little is known about the time course or significance of large airway hypoxia early after transplantation. OBJECTIVES: To e ... Full text Link to item Cite

Heme Oxygenase-1/Carbon Monoxide System and Embryonic Stem Cell Differentiation and Maturation into Cardiomyocytes.

Journal Article Antioxid Redox Signal · March 1, 2016 AIMS: The differentiation of embryonic stem (ES) cells into energetically efficient cardiomyocytes contributes to functional cardiac repair and is envisioned to ameliorate progressive degenerative cardiac diseases. Advanced cell maturation strategies are t ... Full text Open Access Link to item Cite

Mitochondrial Quality Control as a Therapeutic Target.

Journal Article Pharmacol Rev · January 2016 In addition to oxidative phosphorylation (OXPHOS), mitochondria perform other functions such as heme biosynthesis and oxygen sensing and mediate calcium homeostasis, cell growth, and cell death. They participate in cell communication and regulation of infl ... Full text Open Access Link to item Cite

Heme oxygenase-1 regulates mitochondrial quality control in the heart.

Journal Article JCI Insight · 2016 The cardioprotective inducible enzyme heme oxygenase-1 (HO-1) degrades prooxidant heme into equimolar quantities of carbon monoxide, biliverdin, and iron. We hypothesized that HO-1 mediates cardiac protection, at least in part, by regulating mitochondrial ... Full text Open Access Link to item Cite

Effects of striatal nitric oxide production on regional cerebral blood flow and seizure development in rats exposed to extreme hyperoxia.

Journal Article J Appl Physiol (1985) · December 1, 2015 The endogenous vasodilator and signaling molecule nitric oxide has been implicated in cerebral hyperemia, sympathoexcitation, and seizures induced by hyperbaric oxygen (HBO2) at or above 3 atmospheres absolute (ATA). It is unknown whether these events in t ... Full text Open Access Link to item Cite

The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle.

Journal Article Am J Physiol Lung Cell Mol Physiol · October 15, 2015 The heme oxygenase-1 (HO-1)/carbon monoxide (CO) system induces mitochondrial biogenesis, but its biological impact in human skeletal muscle is uncertain. The enzyme system generates CO, which stimulates mitochondrial proliferation in normal muscle. Here w ... Full text Link to item Cite

Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia.

Journal Article Am J Physiol Lung Cell Mol Physiol · October 15, 2015 Inhaled carbon monoxide (CO) gas has therapeutic potential for patients with acute respiratory distress syndrome if a safe, evidence-based dosing strategy and a ventilator-compatible CO delivery system can be developed. In this study, we used a clinically ... Full text Link to item Cite

The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide.

Journal Article Am J Respir Cell Mol Biol · September 2015 Strategies for the treatment of bacterial pneumonia beyond traditional antimicrobial therapy have been limited. The recently discovered novel genus of lipid mediators, coined "specialized proresolving mediators" (SPMs), which orchestrate clearance of recru ... Full text Link to item Cite

Regulation of mitochondrial biogenesis and its intersection with inflammatory responses.

Journal Article Antioxid Redox Signal · April 20, 2015 SIGNIFICANCE: Mitochondria play a vital role in cellular homeostasis and are susceptible to damage from inflammatory mediators released by the host defense. Cellular recovery depends, in part, on mitochondrial quality control programs, including mitochondr ... Full text Link to item Cite

Redox regulation of mitophagy in the lung during murine Staphylococcus aureus sepsis.

Journal Article Free Radic Biol Med · January 2015 Oxidative mitochondrial damage is closely linked to inflammation and cell death, but low levels of reactive oxygen and nitrogen species serve as signals that involve mitochondrial repair and resolution of inflammation. More specifically, cytoprotection rel ... Full text Link to item Cite

Redox mechanisms of cardiomyocyte mitochondrial protection.

Journal Article Front Physiol · 2015 Oxidative and nitrosative stress are primary contributors to the loss of myocardial tissue in insults ranging from ischemia/reperfusion injury from coronary artery disease and heart transplantation to sepsis-induced myocardial dysfunction and drug-induced ... Full text Open Access Link to item Cite

Transcriptional Regulation of Mitochondrial Biogenesis and Quality Control

Chapter · January 1, 2015 The capacity of a cell to renew or expand its mitochondrial population is important for cell survival during periods of intensified energy demand or after episodes of cell damage, particularly in organs with high energy utilization rates, such as the liver ... Full text Cite

Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1.

Journal Article Am J Physiol Lung Cell Mol Physiol · November 15, 2014 Polymorphonuclear leukocyte (PMN)-mediated acute lung injury from ischemia/reperfusion (I/R) remains a major cause of morbidity and mortality in critical care medicine. Here, we report that inhaled low-dose carbon monoxide (CO) and intravenous resolvin D1 ... Full text Link to item Cite

Baroreceptor afferents modulate brain excitation and influence susceptibility to toxic effects of hyperbaric oxygen.

Journal Article J Appl Physiol (1985) · September 1, 2014 Unexplained adjustments in baroreflex sensitivity occur in conjunction with exposures to potentially toxic levels of hyperbaric oxygen. To investigate this, we monitored central nervous system, autonomic and cardiovascular responses in conscious and anesth ... Full text Open Access Link to item Cite

Mitochondria in lung biology and pathology: more than just a powerhouse.

Journal Article Am J Physiol Lung Cell Mol Physiol · June 1, 2014 An explosion of new information about mitochondria reveals that their importance extends well beyond their time-honored function as the "powerhouse of the cell." In this Perspectives article, we summarize new evidence showing that mitochondria are at the c ... Full text Link to item Cite

Development of a novel preclinical model of pneumococcal pneumonia in nonhuman primates.

Journal Article Am J Respir Cell Mol Biol · May 2014 Pneumococcal pneumonia is a leading cause of bacterial infection and death worldwide. Current diagnostic tests for detecting Streptococcus pneumoniae can be unreliable and can mislead clinical decision-making and treatment. To address this concern, we deve ... Full text Link to item Cite

Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis.

Journal Article J Biol Chem · January 3, 2014 A key transcriptional regulator of cell metabolism, the peroxisome proliferator-activated receptor γ co-activator 1-α (PPARGC-1-α or PGC-1α), also regulates mitochondrial biogenesis, but its role in antioxidant gene regulation is not well understood. Here, ... Full text Link to item Cite

Mitochondrial biogenesis: regulation by endogenous gases during inflammation and organ stress.

Journal Article Curr Pharm Des · 2014 The influence of mitochondrial dysfunction on pathological states involving inflammatory and/or oxidative stress in tissues that do not show frank cellular apoptosis or necrosis has been rather difficult to unravel, and the literature is replete with contr ... Full text Link to item Cite

Staphylococcus aureus sepsis induces early renal mitochondrial DNA repair and mitochondrial biogenesis in mice.

Journal Article PLoS One · 2014 Acute kidney injury (AKI) contributes to the high morbidity and mortality of multi-system organ failure in sepsis. However, recovery of renal function after sepsis-induced AKI suggests active repair of energy-producing pathways. Here, we tested the hypothe ... Full text Link to item Cite

Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude.

Journal Article PLoS One · 2014 Rapid ascent to high altitude causes illness and fatigue, and there is a demand for effective acute treatments to alleviate such effects. We hypothesized that increased oxygen delivery to the tissue using a combination of a hypertensive agent and an endoth ... Full text Open Access Link to item Cite

Baroreflex-mediated cardiovascular responses to hyperbaric oxygen.

Journal Article J Appl Physiol (1985) · September 2013 The cardiovascular system responds to hyperbaric hyperoxia (HBO2) with vasoconstriction, hypertension, bradycardia, and reduced cardiac output (CO). We tested the hypothesis that these responses are linked by a common mechanism-activation of the arterial b ... Full text Link to item Cite

Practice recommendations in the diagnosis, management, and prevention of carbon monoxide poisoning

Journal Article Diving and Hyperbaric Medicine · September 1, 2013 Carbon monoxide (CO) poisoning is common in modern society, resulting in significant morbidity and mortality in the United States annually. Over the past two decades, sufficient information has been published about carbon monoxide poisoning in the medical ... Cite

S-nitrosylation therapy to improve oxygen delivery of banked blood.

Journal Article Proc Natl Acad Sci U S A · July 9, 2013 From the perspectives of disease transmission and sterility maintenance, the world's blood supplies are generally safe. However, in multiple clinical settings, red blood cell (RBC) transfusions are associated with adverse cardiovascular events and multiorg ... Full text Link to item Cite

CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension.

Journal Article Am J Respir Cell Mol Biol · May 2013 In pulmonary arterial hypertension (PAH), there is overexpression of the chemokine, C-C chemokine ligand type 2 (CCL2), and infiltration of myeloid cells into the pulmonary vasculature. Inhibition of CCL2 in animals decreases PAH, suggesting that the CCL2 ... Full text Link to item Cite

Automated measurement of blood flow velocity and direction and hemoglobin oxygen saturation in the rat lung using intravital microscopy.

Journal Article Am J Physiol Lung Cell Mol Physiol · January 15, 2013 Intravital microscopy of the pulmonary microcirculation in research animals is of great scientific interest for its utility in identifying regional changes in pulmonary microcirculatory blood flow. Although feasibility studies have been reported, the pulmo ... Full text Link to item Cite

Practice recommendations in the diagnosis, management, and prevention of carbon monoxide poisoning.

Journal Article Am J Respir Crit Care Med · December 1, 2012 Carbon monoxide (CO) poisoning is common in modern society, resulting in significant morbidity and mortality in the United States annually. Over the past two decades, sufficient information has been published about carbon monoxide poisoning in the medical ... Full text Link to item Cite

Redox regulation of mitochondrial biogenesis.

Journal Article Free Radic Biol Med · December 1, 2012 The cell renews, adapts, or expands its mitochondrial population during episodes of cell damage or periods of intensified energy demand by the induction of mitochondrial biogenesis. This bigenomic program is modulated by redox-sensitive signals that respon ... Full text Link to item Cite

Hedgehog controls hepatic stellate cell fate by regulating metabolism.

Journal Article Gastroenterology · November 2012 BACKGROUND & AIMS: The pathogenesis of cirrhosis, a disabling outcome of defective liver repair, involves deregulated accumulation of myofibroblasts derived from quiescent hepatic stellate cells (HSCs), but the mechanisms that control transdifferentiation ... Full text Link to item Cite

The combination of theophylline and endothelin receptor antagonism improves exercise performance of rats under simulated high altitude.

Journal Article J Appl Physiol (1985) · October 15, 2012 Decreased physical performance is a well-known consequence of rapid ascent to high altitude. Hypoxic pulmonary vasoconstriction (HPV) potentially limits cardiac output and systemic blood flow, thus preventing successful adaptation to rapid ascent. We hypot ... Full text Link to item Cite

Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice.

Journal Article Free Radic Biol Med · October 15, 2012 Acute lung injury (ALI) initiates protective responses involving genes downstream of the Nrf2 (Nfe2l2) transcription factor, including heme oxygenase-1 (HO-1), which stimulates mitochondrial biogenesis and related anti-inflammatory processes. We examined m ... Full text Link to item Cite

Brain oxygenation and CNS oxygen toxicity after infusion of perfluorocarbon emulsion.

Journal Article J Appl Physiol (1985) · July 2012 Intravenous perfluorocarbon (PFC) emulsions, administered with supplemental inspired O(2), are being evaluated for their ability to eliminate N(2) from blood and tissue prior to submarine escape, but these agents can increase the incidence of central nervo ... Full text Link to item Cite

What is the role of hyperbaric oxygen in the management of bisphosphonate-related osteonecrosis of the jaw: a randomized controlled trial of hyperbaric oxygen as an adjunct to surgery and antibiotics.

Journal Article J Oral Maxillofac Surg · July 2012 PURPOSE: This study tested hyperbaric oxygen (HBO) as an adjunct to surgery and antibiotics in the treatment of bisphosphonate-related osteonecrosis of the jaw (ONJ) and evaluated its effects on gingival healing, pain, and quality of life. MATERIALS AND ME ... Full text Link to item Cite

Mitochondrial biogenesis: CO and NO too

Conference Nitric Oxide · July 2012 Full text Cite

Regulation of mitochondrial processes by protein S-nitrosylation.

Journal Article Biochim Biophys Acta · June 2012 Featured Publication BACKGROUND: Nitric oxide (NO) exerts powerful physiological effects through guanylate cyclase (GC), a non-mitochondrial enzyme, and through the generation of protein cysteinyl-NO (SNO) adducts-a post-translational modification relevant to mitochondrial bio ... Full text Link to item Cite

Nitric oxide-mediated central sympathetic excitation promotes CNS and pulmonary O₂ toxicity.

Journal Article J Appl Physiol (1985) · June 2012 In hyperbaric oxygen (HBO(2)) at or above 3 atmospheres absolute (ATA), autonomic pathways link central nervous system (CNS) oxygen toxicity to pulmonary damage, possibly through a paradoxical and poorly characterized relationship between central nitric ox ... Full text Link to item Cite

Dual-energy micro-CT of the rodent lung.

Journal Article Am J Physiol Lung Cell Mol Physiol · May 15, 2012 The purpose of this work is to investigate the use of dual-energy micro-computed tomography (CT) for the estimation of vascular, tissue, and air fractions in rodent lungs using a postreconstruction three material decomposition method. Using simulations, we ... Full text Link to item Cite

The opprobrium of Big Tobacco.

Journal Article Am J Respir Crit Care Med · May 1, 2012 Full text Link to item Cite

Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis.

Journal Article Am J Respir Crit Care Med · April 15, 2012 RATIONALE: Mitochondrial damage is an important component of multiple organ failure syndrome, a highly lethal complication of severe sepsis that lacks specific therapy. Mitochondrial quality control is regulated in part by the heme oxygenase-1 (HO-1; Hmox1 ... Full text Link to item Cite

Lung imaging in rodents using dual energy micro-CT.

Journal Article Proc SPIE Int Soc Opt Eng · April 3, 2012 Dual energy CT imaging is expected to play a major role in the diagnostic arena as it provides material decomposition on an elemental basis. The purpose of this work is to investigate the use of dual energy micro-CT for the estimation of vascular, tissue, ... Full text Link to item Cite

Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes.

Journal Article Biochim Biophys Acta · April 2012 BACKGROUND: Cells avoid major mitochondrial damage and energy failure during systemic inflammatory states, such as severe acute infections, by specific targeting of the inflammatory response and by inducing anti-inflammatory and anti-oxidant defenses. Rece ... Full text Link to item Cite

Safe administration of hyperbaric oxygen after bleomycin: a case series of 15 patients.

Journal Article Undersea Hyperb Med · 2012 INTRODUCTION: Supplemental oxygen has been reported to cause pulmonary complications after bleomycin. We describe the safe administration of hyperbaric oxygen (HBO2) after bleomycin in 15 patients. METHODS: Paper and electronic records were reviewed for bl ... Link to item Cite

PGC-1α and the Mitochondrial Antioxidant Response during Sepsis

Conference Free Radical Biology and Medicine · November 2011 Full text Cite

Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression.

Journal Article J Biol Chem · May 6, 2011 Featured Publication The induction of heme oxygenase-1 (HO-1; Hmox1) by inflammation, for instance in sepsis, is associated both with an anti-inflammatory response and with mitochondrial biogenesis. Here, we tested the idea that HO-1, acting through the Nfe2l2 (Nrf2) transcrip ... Full text Link to item Cite

Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage.

Journal Article Stroke · February 2011 Featured Publication BACKGROUND AND PURPOSE: S-nitrosylated hemoglobin (S-nitrosohemoglobin) has been implicated in the delivery of O(2) to tissues through the regulation of microvascular blood flow. This study tested the hypothesis that enhancement of S-nitrosylated hemoglobi ... Full text Open Access Link to item Cite

Staphylococcus aureus sepsis and mitochondrial accrual of the 8-oxoguanine DNA glycosylase DNA repair enzyme in mice.

Journal Article Am J Respir Crit Care Med · January 15, 2011 Featured Publication RATIONALE: Damage to mitochondrial DNA (mtDNA) by the production of reactive oxygen species during inflammatory states, such as sepsis, is repaired by poorly understood mechanisms. OBJECTIVES: To test the hypothesis that the DNA repair enzyme, 8-oxoguanine ... Full text Link to item Cite

A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis.

Journal Article PLoS One · 2011 Featured Publication Activation of the host antibacterial defenses by the toll-like receptors (TLR) also selectively activates energy-sensing and metabolic pathways, but the mechanisms are poorly understood. This includes the metabolic and mitochondrial biogenesis master co-ac ... Full text Link to item Cite

Autonomic activation links CNS oxygen toxicity to acute cardiogenic pulmonary injury.

Journal Article Am J Physiol Lung Cell Mol Physiol · January 2011 Breathing hyperbaric oxygen (HBO₂), particularly at pressures above 3 atmospheres absolute, can cause acute pulmonary injury that is more severe if signs of central nervous system toxicity occur. This is consistent with the activation of an autonomic link ... Full text Link to item Cite

Hyaluronan fragments contribute to the ozone-primed immune response to lipopolysaccharide.

Journal Article J Immunol · December 1, 2010 Hyaluronan is a high-molecular mass component of pulmonary extracelluar matrix, and lung injury can generate a low-molecular mass hyaluronan (HA) fragment that functions as endogenous ligand to cell surface receptors CD44 and TLR4. This leads to activation ... Full text Link to item Cite

Survival in critical illness is associated with early activation of mitochondrial biogenesis.

Journal Article Am J Respir Crit Care Med · September 15, 2010 Featured Publication RATIONALE: We previously reported outcome-associated decreases in muscle energetic status and mitochondrial dysfunction in septic patients with multiorgan failure. We postulate that survivors have a greater ability to maintain or recover normal mitochondri ... Full text Link to item Cite

Hyperbaric oxygen therapy and neurological disease.

Journal Article Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc · September 1, 2010 Cite

Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis.

Journal Article J Cell Sci · August 1, 2010 Featured Publication The nuclear respiratory factor-1 (NRF1) gene is activated by lipopolysaccharide (LPS), which might reflect TLR4-mediated mitigation of cellular inflammatory damage via initiation of mitochondrial biogenesis. To test this hypothesis, we examined NRF1 promot ... Full text Open Access Link to item Cite

Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis.

Journal Article PLoS One · July 15, 2010 The PGC family of transcriptional co-activators (PGC-1alpha [Ppargc1a], PGC-1beta [Ppargc1b], and PRC [Pprc]) coordinates the upregulation of mitochondrial biogenesis, and Ppargc1a is known to be activated in response to mitochondrial damage in sepsis. The ... Full text Link to item Cite

Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart.

Journal Article Circ Res · June 11, 2010 Featured Publication RATIONALE: Erythropoietin (EPO) is often administered to cardiac patients with anemia, particularly from chronic kidney disease, and stimulation of erythropoiesis may stabilize left ventricular and renal function by recruiting protective effects beyond the ... Full text Link to item Cite

Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice.

Journal Article Free Radic Biol Med · March 1, 2010 Nitric oxide synthase-2 (NOS2) plays a critical role in reactive nitrogen species generation and cysteine modifications that influence mitochondrial function and signaling during inflammation. Here, we investigated the role of NOS2 in hepatic mitochondrial ... Full text Link to item Cite

Clinical review: oxygen as a signaling molecule.

Journal Article Crit Care · 2010 Molecular oxygen is obviously essential for conserving energy in a form useable for aerobic life; however, its utilization comes at a cost--the production of reactive oxygen species (ROS). ROS can be highly damaging to a range of biological macromolecules, ... Full text Link to item Cite

Hyperbaric oxygen therapy and neurological disease.

Journal Article Undersea Hyperb Med · 2010 Link to item Cite

Iron Induces Heme-oxygenase-1 Expression And Activity In Endothelial Cells

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2010 Link to item Cite

THE HO/CO SYSTEM PROMOTES HEPATIC MITOCHONDRIAL BIOGENESIS DURING STAPHYLOCOCCUS AUREUS SEPSIS

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2010 Link to item Cite

Multimodality surgical and hyperbaric management of mandibular osteoradionecrosis.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2009 PURPOSE: To elucidate long-term outcomes in 65 consecutive patients meeting a uniform definition of mandibular osteoradionecrosis (ORN) treated with multimodality therapy including hyperbaric oxygen (HBO). METHODS AND MATERIALS: Pretreatment, post-treatmen ... Full text Link to item Cite

Quantitative blood flow measurements in the small animal cardiopulmonary system using digital subtraction angiography.

Journal Article Med Phys · November 2009 PURPOSE: The use of preclinical rodent models of disease continues to grow because these models help elucidate pathogenic mechanisms and provide robust test beds for drug development. Among the major anatomic and physiologic indicators of disease progressi ... Full text Link to item Cite

Extracellular superoxide dismutase regulates cardiac function and fibrosis.

Journal Article J Mol Cell Cardiol · November 2009 Extracellular superoxide dismutase (EC-SOD) is an antioxidant that protects the heart from ischemia and the lung from inflammation and fibrosis. The role of cardiac EC-SOD under normal conditions and injury remains unclear. Cardiac toxicity, a common side ... Full text Link to item Cite

Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation.

Journal Article Trends Mol Med · October 2009 Featured Publication The protected transport of nitric oxide (NO) by hemoglobin (Hb) links the metabolic activity of working tissue to the regulation of its local blood supply through hypoxic vasodilation. This physiologic mechanism is allosterically coupled to the O(2) satura ... Full text Link to item Cite

Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans.

Journal Article Am J Physiol Heart Circ Physiol · July 2009 Given that the physiology of heme oxygenase-1 (HO-1) encompasses mitochondrial biogenesis, we tested the hypothesis that the HO-1 product, carbon monoxide (CO), activates mitochondrial biogenesis in skeletal muscle and enhances maximal oxygen uptake (Vo(2m ... Full text Link to item Cite

Phosphodiesterase-5 inhibitors oppose hyperoxic vasoconstriction and accelerate seizure development in rats exposed to hyperbaric oxygen.

Journal Article J Appl Physiol (1985) · April 2009 Oxygen is a potent cerebral vasoconstrictor, but excessive exposure to hyperbaric oxygen (HBO(2)) can reverse this vasoconstriction by stimulating brain nitric oxide (NO) production, which increases cerebral blood flow (CBF)-a predictor of O(2) convulsions ... Full text Link to item Cite

Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia.

Journal Article Free Radic Biol Med · March 1, 2009 Featured Publication Mitochondrial biogenesis protects metabolism from mitochondrial dysfunction produced by activation of innate immunity by lipopolysaccharide (LPS) or other bacterial products. Here we tested the hypothesis in mouse heart that activation of toll-like recepto ... Full text Link to item Cite

Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity.

Journal Article J Appl Physiol (1985) · February 2009 Recent investigations have elucidated some of the diverse roles played by reactive oxygen and nitrogen species in events that lead to oxygen toxicity and defend against it. The focus of this review is on toxic and protective mechanisms in hyperoxia that ha ... Full text Link to item Cite

Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1.

Journal Article Circ Res · November 21, 2008 Featured Publication Heme oxygenase (HO)-1 is a protective antioxidant enzyme that prevents cardiomyocyte apoptosis, for instance, during progressive cardiomyopathy. Here we identify a fundamental aspect of the HO-1 protection mechanism by demonstrating that HO-1 activity in m ... Full text Link to item Cite

Protecting the Permeability Pore and Mitochondrial Biogenesis

Chapter · October 7, 2008 Recent evidence links the pathogenesis of multiple organ dysfunction syndrome (MODS) in sepsis to mitochondrial damage. Our hypothesis is that cellular mechanisms maintaining mitochondrial function must be protected in order to prevent MODS. Recent animal ... Full text Cite

Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport.

Journal Article Biometals · October 2008 Airway epithelial cells prevent damaging effects of extracellular iron by taking up the metal and sequestering it within intracellular ferritin. Epithelial iron transport is associated with transcellular movement of other cations including changes in the e ... Full text Link to item Cite

SNO-hemoglobin and hypoxic vasodilation.

Journal Article Nat Med · October 2008 Full text Link to item Cite

Carbon monoxide, reactive oxygen signaling, and oxidative stress.

Journal Article Free Radic Biol Med · September 1, 2008 Featured Publication The ubiquitous gas, carbon monoxide (CO), is of substantial biological importance, but apart from its affinity for reduced transition metals, particularly heme-iron, it is surprisingly nonreactive-as is the ferrous-carbonyl-in living systems. CO does form ... Full text Link to item Cite

Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function.

Journal Article Am J Respir Cell Mol Biol · June 2008 The dissociation of iron from heme is a major factor in iron metabolism and the cellular concentrations of the metal correlate with heme degradation. We tested the hypotheses that (1) exposure to a product of heme catabolism, carbon monoxide (CO), alters i ... Full text Link to item Cite

Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects.

Journal Article Am J Physiol Lung Cell Mol Physiol · May 2008 Reactive species of oxygen and nitrogen have been collectively implicated in pulmonary oxygen toxicity, but the contributions of specific molecules are unknown. Therefore, we assessed the roles of several reactive species, particularly nitric oxide, in pul ... Full text Link to item Cite

Transcriptional Regulation of SDHa flavoprotein by nuclear respiratory factor-1 prevents pseudo-hypoxia in aerobic cardiac cells.

Journal Article J Biol Chem · April 18, 2008 Nuclear respiratory factor-1 (NRF-1) is integral to the transcriptional regulation of mitochondrial biogenesis, but its control over various respiratory genes overlaps other regulatory elements including those involved in O(2) sensing. Aerobic metabolism g ... Full text Link to item Cite

Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism.

Journal Article J Neurosci · February 27, 2008 Featured Publication The adaptive mechanisms that protect brain metabolism during and after hypoxia, for instance, during hypoxic preconditioning, are coordinated in part by nitric oxide (NO). We tested the hypothesis that acute transient hypoxia stimulates NO synthase (NOS)-a ... Full text Link to item Cite

Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis.

Journal Article Antioxid Redox Signal · February 2008 Cell survival and injury repair is facilitated by mitochondrial biogenesis; however, the role of this process in lung repair is unknown. We evaluated mitochondrial biogenesis in the mouse lung in two injuries that cause acute inflammation and in two that c ... Full text Link to item Cite

Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study.

Journal Article Respir Res · January 23, 2008 BACKGROUND: Lung injury caused by both inhaled dusts and infectious agents depends on increased availability of iron and metal-catalyzed oxidative stress. Because inhaled particles, such as silica, and certain infections can cause secondary pulmonary alveo ... Full text Link to item Cite

Hyperoxia-induced decrease in organ blood flow [10]

Journal Article Anesthesiology · January 1, 2008 Full text Cite

In reply (Anesthesiology (2008) 108, (169-170))

Journal Article Anesthesiology · January 1, 2008 Cite

Underutilization of echocardiography for patent foramen ovale in divers with serious decompression sickness.

Journal Article Undersea Hyperb Med · 2008 The presence of a patent foramen ovale (PFO) in compressed gas diving has been considered a risk factor for serious decompression illness (DCS) for more than 20 years. We conducted a ten year retrospective chart review aimed at determining if physicians tr ... Link to item Cite

The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy.

Journal Article J Clin Invest · December 2007 Featured Publication The clinical utility of anthracycline anticancer agents, especially doxorubicin, is limited by a progressive toxic cardiomyopathy linked to mitochondrial damage and cardiomyocyte apoptosis. Here we demonstrate that the post-doxorubicin mouse heart fails to ... Full text Open Access Link to item Cite

General discussion I

Journal Article Novartis Foundation Symposium · December 1, 2007 Cite

Discussion

Journal Article Novartis Foundation Symposium · December 1, 2007 Cite

Discussion

Journal Article Novartis Foundation Symposium · December 1, 2007 Cite

Discussion

Journal Article Novartis Foundation Symposium · December 1, 2007 Cite

Discussion

Journal Article Novartis Foundation Symposium · December 1, 2007 Cite

Discussion

Journal Article Novartis Foundation Symposium · December 1, 2007 Cite

Discussion

Journal Article Novartis Foundation Symposium · December 1, 2007 Cite

Discussion

Journal Article Novartis Foundation Symposium · December 1, 2007 Cite

Discussion

Journal Article Novartis Foundation Symposium · December 1, 2007 Cite

Discussion

Conference Novartis Foundation Symposium · December 1, 2007 Cite

Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis.

Journal Article Am J Respir Crit Care Med · October 15, 2007 Featured Publication RATIONALE: The extent, timing, and significance of mitochondrial injury and recovery in bacterial sepsis are poorly characterized, although oxidative and nitrosative mitochondrial damage have been implicated in the development of organ failure. OBJECTIVES: ... Full text Link to item Cite

Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: a case series.

Journal Article J Oral Maxillofac Surg · July 2007 PURPOSE: Bisphosphonate (BP)-associated osteonecrosis of the jaw (ONJ) is an emerging problem with few therapeutic options. Our pilot study of BP-ONJ investigated a possible role for hyperbaric oxygen (HBO(2)) therapy. PATIENTS AND METHODS: A total of 16 p ... Full text Link to item Cite

Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide.

Journal Article Am J Physiol Lung Cell Mol Physiol · July 2007 Featured Publication Pulmonary manifestations of oxygen toxicity were studied and quantified in rats breathing >98% O(2) at 1, 1.5, 2, 2.5, and 3 ATA to test our hypothesis that different patterns of pulmonary injury would emerge, reflecting a role for central nervous system ( ... Full text Link to item Cite

Hyperoxia-induced tissue hypoxia: a danger?

Journal Article Anesthesiology · May 2007 Full text Link to item Cite

A new activating role for CO in cardiac mitochondrial biogenesis.

Journal Article J Cell Sci · January 15, 2007 Featured Publication To investigate a possible new physiological role of carbon monoxide (CO), an endogenous gas involved in cell signaling and cytotoxicity, we tested the hypothesis that the mitochondrial generation of reactive oxygen species by CO activates mitochondrial bio ... Full text Link to item Cite

Early development of near-infrared spectroscopy at Duke University.

Journal Article J Biomed Opt · 2007 Featured Publication Optical monitoring of living tissues in the near-infrared (NIR) region of the spectrum (700 to 1300 nm) was first demonstrated some 30 years ago by Professor Frans F. Jobsis of Duke University. Jobsis had intended to study the oxidation-reduction (redox) b ... Full text Link to item Cite

Protecting the permeability pore and mitochondrial biogenesis.

Journal Article Novartis Found Symp · 2007 Recent evidence links the pathogenesis of multiple organ dysfunction syndrome (MODS) in sepsis to mitochondrial damage. Our hypothesis is that cellular mechanisms maintaining mitochondrial function must be protected in order to prevent MODS. Recent animal ... Full text Link to item Cite

Erythropoietin promotes cardiac mitochondrial biogenesis through Akt activation

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2007 Link to item Cite

Skeletal muscle mitochondrial biogenesis induced by carbon monoxide

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2007 Link to item Cite

Discussion

Journal Article Novartis Foundation Symposium · December 1, 2006 Cite

Metabolic capacity regulates iron homeostasis in endothelial cells.

Journal Article Free Radic Biol Med · December 1, 2006 The sensitivity of endothelial cells to oxidative stress and the high concentrations of iron in mitochondria led us to test the hypotheses that (1) changes in respiratory capacity alter iron homeostasis, and (2) lack of aerobic metabolism decreases labile ... Full text Link to item Cite

How do red blood cells cause hypoxic vasodilation? The SNO-hemoglobin paradigm.

Journal Article Am J Physiol Heart Circ Physiol · October 2006 One of the most intriguing areas of research in erythrocyte physiology is the interaction of hemoglobin with nitric oxide (NO). These two molecules independently fulfill diverse and complex physiological roles, while together they subtly modulate microvasc ... Full text Link to item Cite

Lunar exploration and the advancement of biomedical research: a physiologist's view.

Journal Article Aviat Space Environ Med · October 2006 Over the next few years, it will become apparent just how important lunar exploration is to biomedical research and vice versa, and how critical both are to the future of human spaceflight. NASA's Project Constellation should put a new lunar-capable vehicl ... Link to item Cite

Genetic basis of murine responses to hyperoxia-induced lung injury.

Journal Article Immunogenetics · October 2006 To evaluate the effect of genetic background on oxygen (O2) toxicity, nine genetically diverse mouse strains (129/SvIm, A/J, BALB/cJ, BTBR+(T)/tf/tf, CAST/Ei, C3H/HeJ, C57BL/6J, DBA/2J, and FVB/NJ) were exposed to more than 99% O2 for 72 h. Immediately fol ... Full text Link to item Cite

"Oxygenated" water and athletic performance.

Journal Article Br J Sports Med · September 2006 Ergogenic claims for oxygenated water cannot be taken seriously ... Full text Link to item Cite

Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells.

Journal Article Am J Physiol Lung Cell Mol Physiol · August 2006 Catalytically active iron in the lung causes oxidative stress and promotes microbial growth that can be limited by intracellular sequestration of iron within ferritin. Because cellular iron uptake requires membrane ferrireductase activity that in the gut c ... Full text Link to item Cite

Carbon monoxide, oxidative stress, and mitochondrial permeability pore transition.

Journal Article Free Radic Biol Med · April 15, 2006 The cellular effects of carbon monoxide (CO) are produced primarily by CO binding to iron or other transition metals, which may also promote prooxidant activities of the more reactive gases, oxygen and nitric oxide. We tested the hypothesis that prooxidant ... Full text Link to item Cite

Glutathione regulates susceptibility to oxidant-induced mitochondrial DNA damage in human lymphocytes.

Journal Article Free Radic Biol Med · April 1, 2006 Oxidative damage to mitochondrial DNA (mtDNA) interferes with the expression of mitochondrial-encoded subunits of the electron transport complexes of oxidative phosphorylation. MtDNA is protected by several mitochondrial antioxidant systems, but the specif ... Full text Link to item Cite

Oxidant generation promotes iron sequestration in BEAS-2B cells exposed to asbestos.

Journal Article Am J Respir Cell Mol Biol · March 2006 Lung injury after asbestos exposure is associated with an oxidative stress that is catalyzed by iron in the fiber matrix, complexed to the surface, or both. We tested the hypothesis that the cellular response to asbestos includes the transport and sequestr ... Full text Link to item Cite

A comparison of hyperbaric oxygen versus hypoxic cerebral preconditioning in neonatal rats.

Journal Article Brain Res · February 23, 2006 The potency of hyperbaric preconditioning (HBO-PC) is uncertain compared to well-validated ischemic or hypoxic models and no studies have directly compared HBO-PC to hypoxic preconditioning (HPC). We subjected rat pups to unilateral carotid cauterization f ... Full text Link to item Cite

Physician subsidies for tobacco advertising.

Journal Article Am J Respir Crit Care Med · January 15, 2006 Full text Link to item Cite

Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1.

Journal Article J Biol Chem · January 6, 2006 Featured Publication The nuclear expression of mitochondrial transcription factor A (Tfam), which is required for mitochondrial DNA (mtDNA) transcription and replication, must be linked to cellular energy needs. Because respiration generates reactive oxygen species as a side-p ... Full text Link to item Cite

S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery.

Journal Article Am J Physiol Lung Cell Mol Physiol · January 2006 Endogenous nitric oxide donor compounds (S-nitrosothiols) contribute to low vascular tone by both cGMP-dependent and -independent pathways. We have reported that S-nitrosoglutathione (GSNO) inhibits 5-hydroxytryptamine (5-HT)-mediated pulmonary vasoconstri ... Full text Link to item Cite

Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure.

Journal Article Am J Physiol Lung Cell Mol Physiol · January 2006 Featured Publication Tissue factor expression in sepsis activates coagulation in the lung, which potentiates inflammation and leads to fibrin deposition. We hypothesized that blockade of factor X binding to the tissue factor-factor VIIa complex would prevent sepsis-induced dam ... Full text Link to item Cite

Oxygen-rich water and sports achievement

Journal Article Geneeskunde en Sport · 2006 Cite

Nitric oxide amplifies the excitatory to inhibitory neurotransmitter imbalance accelerating oxygen seizures.

Journal Article Undersea Hyperb Med · 2006 CNS O2 toxicity is manifested most profoundly by generalized motor convulsions. The hypothesis was tested that HBO2 triggers seizures by an excitatory to inhibitory neurotransmitter imbalance produced by neuronal nitric oxide (NO) activity. Anesthetized ra ... Link to item Cite

Oxygen-induced mitochondrial biogenesis in the rat hippocampus.

Journal Article Neuroscience · 2006 The hypothesis that damage to mitochondrial DNA by reactive oxygen species increases the activity of nuclear and mitochondrial transcription factors for mitochondrial DNA replication was tested in the in vivo rat brain. Mitochondrial reactive oxygen specie ... Full text Link to item Cite

Mitochondrial biogenesis in sepsis: a role for inducible nitric oxide synthase

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2006 Link to item Cite

NOX4 mediates thrombin signaling in endothelial cells

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2006 Link to item Cite

A novel electrochemical sensor for nitric oxide using aligned RuO 2 nanowires on a Pt filament

Journal Article 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings · December 1, 2005 A novel electrochemical sensor was prepared for detecting nitric oxide (NO) in biological materials using aligned ruthenium oxide nanowires deposited on a Pt filament by chemical vapor deposition (CVD) in two steps. First, ruthenium carbonyl (Ru 3(CO) 12) ... Cite

Extracellular superoxide dismutase.

Journal Article Int J Biochem Cell Biol · December 2005 The extracellular space is protected from oxidant stress by the antioxidant enzyme extracellular superoxide dismutase (EC-SOD), which is highly expressed in selected tissues including blood vessels, heart, lungs, kidney and placenta. EC-SOD contains a uniq ... Full text Link to item Cite

A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension.

Journal Article Proc Natl Acad Sci U S A · October 11, 2005 The mechanism by which hypoxia [low partial pressure of O(2) (pO(2))] elicits signaling to regulate pulmonary arterial pressure is incompletely understood. We considered the possibility that, in addition to its effects on smooth muscle, hypoxia may influen ... Full text Link to item Cite

Cerebral blood flow and brain oxygenation in rats breathing oxygen under pressure.

Journal Article J Cereb Blood Flow Metab · October 2005 Hyperbaric oxygen (HBO(2)) increases oxygen tension (PO(2)) in blood but reduces blood flow by means of O(2)-induced vasoconstriction. Here we report the first quantitative evaluation of these opposing effects on tissue PO(2) in brain, using anesthetized r ... Full text Link to item Cite

"Low-level" carbon monoxide administration may carry risk.

Journal Article Am J Respir Crit Care Med · September 15, 2005 Full text Link to item Cite

"Low-level" carbon monoxide administration may carry risk [4] (multiple letters)

Journal Article American Journal of Respiratory and Critical Care Medicine · September 15, 2005 Full text Cite

Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli.

Journal Article FASEB J · September 2005 Featured Publication An important site of cellular damage in bacterial sepsis is mitochondrial DNA (mtDNA), which we proposed is caused by reactive oxygen and nitrogen species generated by activation of signaling through specific toll-like receptors (TLR). In wild-type (Wt) mi ... Full text Link to item Cite

Divalent metal transporter-1 decreases metal-related injury in the lung.

Journal Article Am J Physiol Lung Cell Mol Physiol · September 2005 Exposure to airborne particulates makes the detoxification of metals a continuous challenge for the lungs. Based on the fate of iron in airway epithelial cells, we postulated that divalent metal transporter-1 (DMT1) participates in detoxification of metal ... Full text Link to item Cite

TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells.

Journal Article Am J Physiol Lung Cell Mol Physiol · July 2005 Regulation of the metal transport protein divalent metal transporter-1 (DMT1) may contribute to the uptake and detoxification of iron by cells resident in the respiratory tract. Inflammation has been associated with an increased availability of this metal ... Full text Link to item Cite

Electrochemical detection of nitric oxide in biological fluids.

Journal Article Methods Enzymol · 2005 The challenges that must be overcome in order to detect nitric oxide (NO) in biological fluids include its low physiological concentration (1-nM) and its short half-life (a few seconds or less). Electrochemistry is capable of making such measurements, if c ... Full text Link to item Cite

Transient carbon monoxide exposure induces cardiac mitochondriobiogenic response.

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2005 Link to item Cite

Carbon monoxide actuates O(2)-limited heme degradation in the rat brain.

Journal Article Free Radic Biol Med · December 1, 2004 The biochemical paradigm for carbon monoxide (CO) is driven by the century-old Warburg hypothesis: CO alters O(2)-dependent functions by binding heme proteins in competitive relation to 1/oxygen partial pressure (PO(2)). High PO(2) thus hastens CO eliminat ... Full text Link to item Cite

Red Blood Cell S-Nitrosohemoglobin Deficiency in Pulmonary Arterial Hypertension.

Conference Blood · November 16, 2004 AbstractRecent studies have suggested that binding of oxygen to hemoglobin (Hb) facilitates reactions of nitric oxide (NO) that lead to production of S-nitrosohemoglobin (SNO-Hb), and that vasodilator S-nitr ... Full text Cite

Hypoxic Vasodilation by Red Blood Cells and Impairment in Vascular Disorders.

Conference Blood · November 16, 2004 AbstractPhysiological O2 gradients are principal regulators of blood flow in the microcirculation: position-to-position changes in hemoglobin (Hb) O2 saturation are coupled to regulated vasodilation (“hypoxi ... Full text Cite

Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis.

Journal Article Cardiovasc Res · November 1, 2004 OBJECTIVE: The responses to bacterial lipopolysaccharide (LPS) damage mitochondria by generating oxidative stress within the organelles. We postulated that LPS damages heart mitochondrial DNA and protein by oxidation, and that this is recovered by oxidativ ... Full text Link to item Cite

The acute respiratory distress syndrome.

Journal Article Ann Intern Med · September 21, 2004 Full text Link to item Cite

Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch.

Journal Article Eur Respir J · August 2004 Lung overstretch involves mechanical factors, including large tidal volumes (VT), which induce inflammatory responses. The current authors hypothesised that inspiratory flow contributes to ventilator-induced inflammation. Buffer-perfused rabbit lungs were ... Full text Link to item Cite

Discordant extracellular superoxide dismutase expression and activity in neonatal hyperoxic lung.

Journal Article Am J Respir Crit Care Med · August 1, 2004 Antioxidant defenses in the neonatal lung are required to adapt to the oxygen (O(2))-rich postnatal environment, and oxidant/antioxidant imbalance is a predisposition to lung injury when high concentrations of inspired O(2) are used in neonatal lung diseas ... Full text Link to item Cite

Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia.

Journal Article Blood · July 1, 2004 Extracellular superoxide dismutase (SOD3) is the primary extracellular enzymatic scavenger of superoxide ((.)O(2)(-)). SOD3's expression is highest in the kidney, but its distribution and biologic functions there are unknown. To investigate the function of ... Full text Link to item Cite

How do red blood cells dilate blood vessels?

Journal Article Circ Res · June 25, 2004 Link to item Cite

Pathology: whales, sonar and decompression sickness.

Journal Article Nature · April 15, 2004 We do not yet know why whales occasionally strand after sonar has been deployed nearby, but such information is important for both naval undersea activities and the protection of marine mammals. Jepson et al. suggest that a peculiar gas-forming disease aff ... Full text Link to item Cite

The iron cycle and oxidative stress in the lung.

Journal Article Free Radic Biol Med · April 1, 2004 Iron is critical for many aspects of cellular function, but it can also generate reactive oxygen species that can damage biological macromolecules. To limit oxidative stress, iron acquisition and its distribution must be tightly regulated. In the lungs, wh ... Full text Link to item Cite

Superoxide dismutase responds to hyperoxia in rat hippocampus.

Journal Article Undersea Hyperb Med · 2004 The brain's anti-oxidant response to highly elevated oxygen (O2) partial pressures is poorly understood. In this study we hypothesized that hyperbaric O2 (HBO2) would stimulate superoxide dismutase (SOD) transcription in the oxidative stress-sensitive rat ... Link to item Cite

A Mini-Forum on air breaks and O 2 toxicity in clinical HBO 2 therapy

Journal Article Undersea and Hyperbaric Medicine · 2004 Cite

Carbon monoxide poisoning.

Journal Article Undersea Hyperb Med · 2004 Link to item Cite

Bicarbonate-dependent superoxide release and pulmonary artery tone.

Journal Article Am J Physiol Heart Circ Physiol · December 2003 Pulmonary vasoconstriction is influenced by inactivation of nitric oxide (NO) with extracellular superoxide (O2-*). Because the short-lived O2-* anion cannot diffuse across plasma membranes, its release from vascular cells requires specialized mechanisms t ... Full text Link to item Cite

Superoxide-dependent iron uptake: a new role for anion exchange protein 2.

Journal Article Am J Respir Cell Mol Biol · December 2003 Lung cells import iron across the plasma membrane as ferrous (Fe2+) ion by incompletely understood mechanisms. We tested the hypothesis that human bronchial epithelial (HBE) cells import non-transferrin-bound iron (NTBI) using superoxide-dependent ferri-re ... Full text Link to item Cite

Oxygenated Water and Athletic Performance [6]

Journal Article JAMA · November 12, 2003 Full text Cite

Oxygenated water and athletic performance.

Journal Article JAMA · November 12, 2003 Full text Link to item Cite

Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1.

Journal Article J Biol Chem · October 17, 2003 Exposure to bacterial lipopolysaccharide (LPS) in vivo damages mitochondrial DNA (mtDNA) and interferes with mitochondrial transcription and oxidative phosphorylation (OXPHOS). Because this damage accompanies oxidative stress and is reversible, we postulat ... Full text Link to item Cite

Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia.

Journal Article J Cereb Blood Flow Metab · October 2003 Hyperoxia causes a transient decrease in CBF, followed by a later rise. The mediators of these effects are not known. We used mice lacking endothelial or neuronal nitric oxide synthase (NOS) isoforms (eNOS-/- and nNOS-/- mice) to study the roles of the NOS ... Full text Link to item Cite

Oxalate deposition on asbestos bodies.

Journal Article Hum Pathol · August 2003 We report on a deposition of oxalate crystals on ferruginous bodies after occupational exposure to asbestos demonstrated in 3 patients. We investigated the mechanism and possible significance of this deposition by testing the hypothesis that oxalate genera ... Full text Link to item Cite

Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases.

Journal Article Neurosci Lett · June 19, 2003 Nitric oxide (NO) from endothelial or neuronal NO synthases (eNOS or nNOS) may contribute both to the cerebrovascular responses to oxygen and potentially to the peroxynitrite-mediated toxic effects of hyperbaric oxygen (HBO(2)) on the central nervous syste ... Full text Link to item Cite

Electrochemical activation of electrodes for amperometric detection of nitric oxide.

Journal Article Nitric Oxide · June 2003 An open question in the literature of nitric oxide detection was investigated: does electrochemical activation account for the enhanced properties of certain presumed chemically-modified electrodes? Uniform electrodes of graphite, iridium, palladium, plati ... Full text Link to item Cite

DMT1 expression is increased in the lungs of hypotransferrinemic mice.

Journal Article Am J Physiol Lung Cell Mol Physiol · June 2003 Despite a lack of transferrin, hypotransferrinemic (Hp) mice demonstrate an accumulation of iron in peripheral organs including the lungs. One potential candidate for such transferrin-independent uptake of iron is divalent metal transporter-1 (DMT1), an es ... Full text Link to item Cite

Blockade of tissue factor: treatment for organ injury in established sepsis.

Journal Article Am J Respir Crit Care Med · May 1, 2003 Blockade of tissue factor before lethal sepsis prevents acute lung injury and renal failure in baboons, indicating that activation of coagulation by tissue factor is an early event in the pathogenesis of acute lung injury and organ dysfunction. We hypothes ... Full text Link to item Cite

Postlipopolysaccharide oxidative damage of mitochondrial DNA.

Journal Article Am J Respir Crit Care Med · February 15, 2003 Selected structural and functional alterations of mitochondria induced by bacterial lipopolysaccharide (LPS) were investigated on the basis of the hypothesis that LPS initiates hepatic mitochondrial DNA (mtDNA) damage by oxidative mechanisms. After a singl ... Full text Link to item Cite

Topical oxygen is not hyperbaric oxygen (HBO2).

Journal Article Undersea Hyperb Med · 2003 Link to item Cite

Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity.

Journal Article Free Radic Biol Med · December 15, 2002 Superoxide plays a role in blood pressure regulation in certain vascular diseases, however, its involvement in regulating basal blood pressure is uncertain. Vascular superoxide concentrations are limited by extracellular superoxide dismutase (EC-SOD), whic ... Full text Link to item Cite

Regulation of the brain's vascular responses to oxygen.

Journal Article Circ Res · November 29, 2002 The mechanism of oxygen-induced cerebral vasoconstriction has been sought for more than a century. Using genetically altered mice to enhance or disrupt extracellular superoxide dismutase (EC-SOD, SOD3), we tested the hypothesis that this enzyme plays a cri ... Full text Link to item Cite

Iron increases expression of iron-export protein MTP1 in lung cells.

Journal Article Am J Physiol Lung Cell Mol Physiol · November 2002 Accumulation of reactive iron in acute and chronic lung disease suggests that iron-driven free radical formation could contribute to tissue injury. Safe transport and sequestration of this metal is likely to be of importance in lung defense. We provide evi ... Full text Link to item Cite

Alveolar barrier function assessed by hydrophobic and hydrophilic fluorescent solutes in rabbit lung.

Journal Article Respir Physiol Neurobiol · October 23, 2002 Loss of alveolar barrier function is important in the development of pulmonary edema, but quantitation of its integrity has been difficult in the intact lung. We report a new non-radioactive method to assess paracellular and transcellular permeability of a ... Full text Link to item Cite

Carbon monoxide poisoning.

Journal Article N Engl J Med · October 3, 2002 Full text Link to item Cite

Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells.

Journal Article Am J Physiol Lung Cell Mol Physiol · October 2002 Anion exchange protein 2 (AE2) is a membrane-bound protein that mediates chloride-bicarbonate exchange. In addition to regulating intracellular pH and cell volume, AE2 exports superoxide (O.) to the extracellular matrix in an HCO-dependent process. Given t ... Full text Link to item Cite

Prenatal hypoxia decreases lung extracellular superoxide dismutase expression and activity.

Journal Article Am J Physiol Lung Cell Mol Physiol · September 2002 Extracellular superoxide dismutase (EC-SOD), which scavenges extracellular superoxide (O.), is highly regulated in the developing lung. In the prenatal rabbit, EC-SOD is predominantly intracellular and inactive, and postnatally, active EC-SOD is secreted. ... Full text Link to item Cite

Coagulation and inflammation in acute lung injury.

Journal Article Thromb Haemost · July 2002 The acute respiratory distress syndrome (ARDS) is a severe lung injury in patients with sepsis and other acute inflammatory insults, which is characterized by fibrin deposition in the pulmonary parenchyma, vasculature, and airspaces. Recent evidence sugges ... Link to item Cite

Nitric oxide in the human respiratory cycle.

Journal Article Nat Med · July 2002 Interactions of nitric oxide (NO) with hemoglobin (Hb) could regulate the uptake and delivery of oxygen (O(2)) by subserving the classical physiological responses of hypoxic vasodilation and hyperoxic vasconstriction in the human respiratory cycle. Here we ... Full text Link to item Cite

Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide.

Journal Article Am J Respir Cell Mol Biol · June 2002 Initiation of coagulation by tissue factor (TF) is a potentially powerful regulator of local inflammatory responses. We hypothesized that blockade of TF-factor VIIa (FVIIa) complex would decrease lung inflammation and proinflammatory cytokine release after ... Full text Link to item Cite

Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione.

Journal Article Am J Physiol Lung Cell Mol Physiol · May 2002 Nitric oxide (NO) functions as an endothelium-derived relaxing factor by activating guanylate cyclase to increase cGMP levels. However, NO and related species may also regulate vascular tone by cGMP-independent mechanisms. We hypothesized that naturally oc ... Full text Link to item Cite

Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells.

Journal Article Am J Physiol Lung Cell Mol Physiol · May 2002 The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin ... Full text Link to item Cite

Carbon monoxide promotes hypoxic pulmonary vascular remodeling.

Journal Article Am J Physiol Lung Cell Mol Physiol · April 2002 CO is a biologically active gas that produces cellular effects by multiple mechanisms. Because cellular binding of CO by heme proteins is increased in hypoxia, we tested the hypothesis that CO interferes with hypoxic pulmonary vascular remodeling in vivo. ... Full text Link to item Cite

Biological chemistry of carbon monoxide.

Journal Article Antioxid Redox Signal · April 2002 Carbon monoxide (CO) has many effects in biology due to its complex biochemical activities. These actions of CO depend primarily on its ability to bind heme proteins (Hp) and to inhibit or alter their biochemical functions. Whether CO is derived from exoge ... Full text Link to item Cite

Nitric oxide and differential effects of ATP on mitochondrial permeability transition.

Journal Article Nitric Oxide · February 2002 The mitochondrial permeability transition pore (PTP) undergoes a calcium-dependent transition (MPT) that disrupts membrane potential and releases apoptogenic proteins. Because PTP opening is enhanced by oxidation of thiols at the so-called "S-site," we hyp ... Full text Link to item Cite

Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure.

Journal Article Free Radic Biol Med · February 1, 2002 The amounts of superoxide and hydrogen peroxide generated by mitochondria under physiological conditions can be enhanced by cellular stress. This study tested the hypothesis that the response to hemin-induced stress, which includes heme oxygenase-1 (HO-1) ... Full text Link to item Cite

Electrochemical detection of physiological nitric oxide: materials and methods.

Journal Article Methods Enzymol · 2002 Advances in the electroanalytical technology of NO detection make it possible to detect the release of robust concentrations of NO from living systems under pathological or pharmacological conditions. However, technical improvements should enable the const ... Full text Link to item Cite

Internal carotid artery dissection in stroke from SCUBA diving: a case report.

Journal Article Undersea Hyperb Med · 2002 Although diving with compressed air is generally safe, neurological problems resulting from infarction in SCUBA diving are well known, including arterial gas embolism and decompression sickness (caisson's disease, bends) involving the brain and spinal cord ... Link to item Cite

Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons.

Journal Article Am J Respir Crit Care Med · November 15, 2001 Sepsis-induced tissue factor (TF) expression activates coagulation in the lung and leads to a procoagulant environment, which results in fibrin deposition and potentiates inflammation. We hypothesized that preventing initiation of coagulation at TF-Factor ... Full text Link to item Cite

Nitric oxide production is enhanced in rat brain before oxygen-induced convulsions.

Journal Article Brain Res · November 2, 2001 Central nervous system oxygen toxicity (CNS O2 toxicity) is preceded by release of hyperoxic vasoconstriction, which increases regional cerebral blood flow (rCBF). These increases in rCBF precede the onset of O2-induced convulsions. We have tested the hypo ... Full text Link to item Cite

Tissue factor in experimental acute lung injury.

Journal Article Semin Hematol · October 2001 Acute lung injury (ALI) is characterized by fibrin deposition in the tissue and vascular spaces. Coagulation is activated after exposure to endotoxin or bacteria, and a procoagulant environment rapidly develops in the vascular, interstitial, and alveolar s ... Full text Link to item Cite

Inhaled carbon monoxide and hyperoxic lung injury in rats.

Journal Article Am J Physiol Lung Cell Mol Physiol · October 2001 Because carbon monoxide (CO) has been proposed to have anti-inflammatory properties, we sought protective effects of CO in pulmonary O(2) toxicity, which leads rapidly to lung inflammation and respiratory failure. Based on published studies, we hypothesize ... Full text Link to item Cite

Vascular release of nonheme iron in perfused rabbit lungs.

Journal Article Am J Physiol Lung Cell Mol Physiol · March 2001 In this study, we hypothesized that the lung actively releases excess iron into the circulation to regulate iron homeostasis. We measured nonheme iron (NHFe) in the perfusate of control isolated perfused rabbit lungs and lungs with ischemia-reperfusion (I/ ... Full text Link to item Cite

Antibody to intercellular adhesion molecule 1 (CD54) decreases survival and not lung injury in baboons with sepsis.

Journal Article Am J Respir Crit Care Med · March 2001 Neutrophil influx into the lung is an important event in the pathogenesis of acute lung injury in gram-negative sepsis. We hypothesized that administration of a monoclonal antibody to intercellular adhesion molecule 1 (ICAM-1, CD54), a molecule mediating n ... Full text Link to item Cite

Alveolar proteinosis: a disease of mice and men.

Journal Article Am J Physiol Lung Cell Mol Physiol · March 2001 Full text Link to item Cite

Tissue factor in experimental acute lung injury

Journal Article Seminars in Hematology · January 1, 2001 Acute lung injury (ALI) is characterized by fibrin deposition in the tissue and vascular spaces. Coagulation is activated after exposure to endotoxin or bacteria, and a procoagulant environment rapidly develops in the vascular, interstitial, and alveolar s ... Full text Cite

Carbon monoxide poisoning: interpretation of randomized clinical trials and unresolved treatment issues.

Journal Article Undersea Hyperb Med · 2001 Since hyperbaric oxygen therapy (HBO2) appeared as a treatment for CO poisoning in 1960, whether and when to use it for CO poisoning have often been debated. HBO2 has been advocated to treat severe CO poisoning to limit delayed and permanent neurologic seq ... Link to item Cite

Mitochondrial DNA deletion decreases cytochrome oxidase subunit IV

Journal Article FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2001 Link to item Cite

Nitric oxide in the respiratory cycle in human health and disease

Journal Article FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2001 Link to item Cite

Hepatic mitochondrial DNA damage and oxidative stress by lipopolysaccharide (LPS)

Journal Article FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2001 Link to item Cite

Species-specific hemodynamic effects of metalloporphyrin SOD mimetics

Journal Article FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2001 Link to item Cite

Iron uptake in bronchial epithelial cells requires O2-transport by anion exchange protein 2

Journal Article FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2001 Link to item Cite

Activation of NO electrodes

Journal Article FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2001 Link to item Cite

Hyperbaric oxygen reduces cerebral blood flow by inactivating nitric oxide.

Journal Article Nitric Oxide · December 2000 Based on recent evidence that nitric oxide (NO(.)) is involved in hyperoxic vasoconstriction, we tested the hypothesis that decreases in NO(.) availability in brain tissue during hyperbaric oxygen (HBO(2)) exposure contribute to decreases in regional cereb ... Full text Link to item Cite

Secretion of extracellular superoxide dismutase in neonatal lungs.

Journal Article Am J Physiol Lung Cell Mol Physiol · November 2000 Extracellular superoxide dismutase (EC-SOD), the only known enzymatic scavenger of extracellular superoxide, may modulate reactions of nitric oxide (NO) in the lungs by preventing reactions between superoxide and NO. The regulation of EC-SOD has not been e ... Full text Link to item Cite

Regulation of tumor necrosis factor cytotoxicity by calcineurin.

Journal Article FEBS Lett · October 20, 2000 Cyclosporin (CsA) inhibits mitochondrial death signaling and opposes tumor necrosis factor (TNF)-induced apoptosis in vitro. However, CsA is also a potent inhibitor of calcineurin, a phosphatase that may participate in cell death. Therefore, we tested the ... Full text Link to item Cite

Laryngeal radionecrosis and hyperbaric oxygen therapy: report of 18 cases and review of the literature.

Journal Article Ann Otol Rhinol Laryngol · June 2000 Laryngeal radionecrosis is a difficult late complication of radiotherapy. It is associated with hoarseness, edema, pain, weight loss, and upper airway obstruction. The medical treatment options are limited, and in severe cases, the patient may require trac ... Full text Link to item Cite

Calcium oxalate and iron accumulation in sarcoidosis.

Journal Article Sarcoidosis Vasc Diffuse Lung Dis · June 2000 BACKGROUND: In many patients with sarcoidosis, the granulomas contain inclusion bodies within giant cells. Many giant cells contain crystalline oxalate that chemically coordinates iron on the surface of the crystal. If this iron is incompletely coordinated ... Link to item Cite

Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy.

Journal Article Shock · May 2000 Cytokine mediators and leukocyte-endothelial cell adhesion molecules are critical and interdependent components of the acute inflammatory response in sepsis. We hypothesized that the administration of monoclonal antibodies to intercellular adhesion molecul ... Full text Link to item Cite

Near-infrared spectroscopy for monitoring muscle oxygenation.

Journal Article Acta Physiol Scand · April 2000 Near-infrared spectroscopy (NIRS) is a non-invasive method for monitoring oxygen availability and utilization by the tissues. In intact skeletal muscle, NIRS allows semi-quantitative measurements of haemoglobin plus myoglobin oxygenation (tissue O2 stores) ... Full text Link to item Cite

Nitric oxide and cerebral blood flow responses to hyperbaric oxygen.

Journal Article J Appl Physiol (1985) · April 2000 We have tested the hypothesis that cerebral nitric oxide (NO) production is involved in hyperbaric O(2) (HBO(2)) neurotoxicity. Regional cerebral blood flow (rCBF) and electroencephalogram (EEG) were measured in anesthetized rats during O(2) exposure to 1, ... Full text Link to item Cite

Detection of granulocyte-macrophage colony-stimulating factor in patients with pulmonary alveolar proteinosis.

Journal Article Am J Respir Crit Care Med · April 2000 Pulmonary alveolar proteinosis (PAP) is an idiopathic lung disease in which the alveolar spaces are filled with surfactant. Recently, it has been proposed that PAP is caused by deficiency of granulocyte-macrophage colony-stimulating factor (GM-CSF) because ... Full text Link to item Cite

Expression of heme oxygenase-1 in the lung in chronic hypoxia.

Journal Article Am J Physiol Lung Cell Mol Physiol · April 2000 Heme oxygenase (HO)-1 is an oxygen-dependent enzyme that may regulate vascular tone and cell proliferation through the production of carbon monoxide (CO). We tested the hypothesis that HO-1 is upregulated in the lung in chronic hypoxia by exposing male Spr ... Full text Link to item Cite

Electrode materials for nitric oxide detection.

Journal Article Nitric Oxide · February 2000 Nitric oxide oxidation signals were compared for uniform test electrodes of platinum, iridium, palladium, rhodium, ruthenium, gold, graphite, and a nickel-porphyrin on graphite in deaerated phosphate-buffered saline (pH 7.0) at 35 degrees C. All tested mat ... Full text Link to item Cite

Oxidative stress and adenine nucleotide control of mitochondrial permeability transition.

Journal Article Free Radic Biol Med · January 15, 2000 Mitochondria can initiate apoptosis by releasing cytochrome c after undergoing a calcium-dependent permeability transition (MPT). Although the MPT is enhanced by oxidative stress and prevented by adenine nucleotides such as adenosine 5'-diphosphate (ADP), ... Full text Link to item Cite

Oxygen toxicity.

Journal Article Respir Care Clin N Am · June 1999 That hyperoxia induces "a profound modification in the metabolism of tissues" is an old observation. The mechanisms by which the physiologic, pathologic, and biomechanical perturbations caused by oxygen relate to the in vivo manifestations of oxygen toxici ... Link to item Cite

Diagnosis and treatment of carbon monoxide poisoning.

Journal Article Respir Care Clin N Am · June 1999 Carbon monoxide (CO) poisoning is a common occurrence in today's society. Most such poisonings are a direct consequence of inhaling the toxic byproducts of combustion. Exposure to toxic amounts of CO occurs most often during inhalation of automobile exhaus ... Link to item Cite

Physiology of hyperbaric hyperoxia.

Journal Article Respir Care Clin N Am · March 1999 This article reviews the essential physiology of oxygen exchange in the lungs, oxygen transport to tissue, and oxygen utilization by the body tissues. The physiologic effects of hyperbaric hyperoxia are summarized, with an emphasis on the circulatory respo ... Link to item Cite

GM-CSF in alveolar macrophages in pulmonary alveolar proteinosis.

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · March 1, 1999 Link to item Cite

Lung heme oxygenase-1 in chronic hypoxia.

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · March 1, 1999 Link to item Cite

Iron transport in bronchial epithelial cells requires superoxide and anion exchange activity.

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · March 1, 1999 Link to item Cite

LPS amplifies or attenuates endotoxin-induced acute lung injury in mice depending on route of priming exposure.

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · March 1, 1999 Link to item Cite

Inhibition of anion exchange function increases epithelial permeability in perfused lung.

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · March 1, 1999 Link to item Cite

Regulation of tumor necrosis factor cytotoxicity by calcineurin.

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · March 1, 1999 Link to item Cite

Chapter 8 Cellular injury in sepsis

Journal Article Principles of Medical Biology · December 1, 1998 Full text Cite

Induction of ferritin and heme oxygenase-1 by endotoxin in the lung.

Journal Article Am J Physiol · September 1998 Heme oxygenase (HO)-1 expression is increased by forms of oxidative stress that also induce ferritin. Even though this could result from release of iron by heme degradation, we hypothesized that ferritin expression in the lung after endotoxin [lipopolysacc ... Full text Link to item Cite

Induction of ferritin and heme oxygenase-1 by endotoxin in the lung

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY · September 1, 1998 Link to item Cite

Bacterial priming increases lung injury in gram-negative sepsis.

Journal Article Am J Respir Crit Care Med · August 1998 Sepsis syndrome is a leading cause of acute respiratory distress syndrome (ARDS), but the development of acute lung injury is highly variable for reasons that are poorly understood. We hypothesized that nonlethal systemic exposure to gram-negative bacteria ... Full text Link to item Cite

Role of surfactant and hyperoxia.

Journal Article J Appl Physiol (1985) · August 1998 Full text Link to item Cite

Role of surfactant and Hyperoxia - Reply

Journal Article JOURNAL OF APPLIED PHYSIOLOGY · August 1, 1998 Link to item Cite

Induction of arginase isoforms in the lung during hyperoxia.

Journal Article Am J Physiol · July 1998 L-Arginine can be metabolized by nitric oxide (NO) synthase (NOS) to produce NO or by arginase to produce urea and L-ornithine. In the liver, arginase (the AI isoform) is a key enzyme in the urea cycle. In extrahepatic organs including the lung, the functi ... Full text Link to item Cite

Mitochondrial respiration after sepsis and prolonged hypoxia.

Journal Article Am J Physiol · July 1998 Recently, marked oxygen dependence of respiration by isolated mitochondria after exposure to prolonged hypoxia has been described. Because mitochondrial oxygen-dependent respiration could significantly influence oxygen consumption during critical illness, ... Full text Link to item Cite

Mitochondrial respiration after sepsis and prolonged hypoxia

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY · July 1, 1998 Link to item Cite

Induction of arginase isoforms in the lung during hyperoxia

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY · July 1, 1998 Link to item Cite

Lung-specific induction of heme oxygenase-1 and hyperoxic lung injury.

Journal Article Am J Physiol Lung Cell Mol Physiol · April 1, 1998 Heme oxygenase (HO)-1, which catalyzes heme breakdown, is induced by oxidative stress and may protect against oxidative injury. We hypothesized that induction of HO-1 by hemoglobin (Hb) in the lung would protect the rat from pulmonary O2toxicity. Rats give ... Full text Link to item Cite

Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis.

Journal Article Shock · April 1998 The intercellular adhesion molecule (ICAM)-1 is expressed constitutively in normal lungs and increased in pulmonary inflammation. Whether increased ICAM-1 expression in the lung contributes to neutrophil sequestration during lung inflammation in sepsis is ... Full text Link to item Cite

Myocardial oxygenation in dogs during reactive hyperemia.

Journal Article J Biomed Opt · April 1998 The mechanisms of myocardial oxygenation during reactive hyperemia were studied in the beating heart using continuous near infrared (NIR) spectroscopy. In open chest dogs, NIR spectroscopy was used to monitor brief occlusions of the left anterior descendin ... Full text Link to item Cite

Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons.

Journal Article Am J Respir Crit Care Med · March 1998 Recruitment of polymorphonuclear leukocytes (PMN) through upregulation of cellular adhesion molecules is a proposed mechanism of injury in sepsis and acute respiratory distress syndrome (ARDS). We hypothesized that pretreatment of baboons with a monoclonal ... Full text Link to item Cite

Spontaneous intercostal bulge.

Journal Article Postgrad Med J · March 1998 Full text Link to item Cite

Differential expression of arginase and iNOS in the lung in sepsis.

Journal Article Exp Lung Res · 1998 The primary metabolic fates of L-arginine are conversion to L-citrulline by nitric oxide synthase (NOS) and to L-ornithine by arginase. In the lung, arginine utilization is increased after the inducible form of NOS (iNOS) is expressed during inflammation. ... Full text Link to item Cite

Measurement of cerebral blood flow in rats and mice by hydrogen clearance during hyperbaric oxygen exposure.

Journal Article Undersea Hyperb Med · 1998 The hydrogen (H2) clearance method was adapted for the measurement of regional cerebral blood flow (rCBF) in anesthetized rats and mice during hyperbaric oxygen (HBO2) exposure. Polarographic platinum electrodes 0.1 mm in diameter were used to record H2 cl ... Link to item Cite

The release of iron from different asbestos structures by hydrogen peroxide with concomitant O2 generation.

Journal Article Biometals · January 1998 Treatment of aqueous suspensions of different asbestos fibers (amosite, anthophyllite, chrysotile, and crocidolite) at 0-4 degrees C and pH 7.2 with H2O2 results in the consumption of H2O2 with concomitant release of iron and production of O2. During incub ... Full text Link to item Cite

Nitration of membrane proteins in lungs after normoxic ischemia-reperfusion.

Journal Article FREE RADICAL BIOLOGY AND MEDICINE · January 1, 1998 Link to item Cite

Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury

Journal Article American Journal of Physiology · December 1, 1997 Because both the biosynthesis of nitric oxide (NO·) and its metabolic fate are related to molecular O2, we hypothesized that hypoxia would alter the effects of NO- during ischemia-reperfusion (IR) in the lung. In this study, buffer-perfused lungs from rabb ... Cite

Algorithms for in vivo near-infrared spectroscopy.

Journal Article Anal Biochem · November 15, 1997 Full text Link to item Cite

Oxidative metabolism in rat hepatocytes and mitochondria during sepsis.

Journal Article Arch Biochem Biophys · September 15, 1997 We hypothesized that cellular oxygen consumption is abnormal during sepsis as a result of increased oxidative stress and selective mitochondrial damage. In a rat model of sepsis (cecal ligation and puncture), we studied the respiratory characteristics of i ... Full text Link to item Cite

Apoptosis and delayed neuronal damage after carbon monoxide poisoning in the rat.

Journal Article Exp Neurol · September 1997 Delayed neurological damage after CO hypoxia was studied in rats to determine whether programmed cell death (PCD), in addition to necrosis, is involved in neuronal death. In rats exposed to either air or CO (2500 ppm), microdialysis in brain cortex and hip ... Full text Link to item Cite

Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury.

Journal Article Am J Physiol · September 1997 Because both the biosynthesis of nitric oxide (NO.) and its metabolic fate are related to molecular O2, we hypothesized that hypoxia would alter the effects of NO. during ischemia-reperfusion (IR) in the lung. In this study, buffer-perfused lungs from rabb ... Full text Link to item Cite

Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury

Conference AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY · September 1, 1997 Link to item Cite

Protection of perfused lung from oxidant injury by inhibitors of anion exchange.

Journal Article Am J Physiol · August 1997 Hyperoxic lung injury is enhanced in isolated perfused lungs (IPL) in the presence of L-arginine. Reactive O2 species such as superoxide anion (O2-.) produced during hyperoxia are known to react with nitric oxide to form the strong oxidant species peroxyni ... Full text Link to item Cite

Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. I. Physiology and biochemistry.

Journal Article J Appl Physiol (1985) · August 1997 Prolonged hyperoxia causes lung injury and respiratory failure secondary to oxidative tissue damage mediated, in part, by the superoxide anion. We hypothesized that aerosol treatment with recombinant human manganese superoxide dismutase (rhMnSOD) would att ... Full text Link to item Cite

Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. II. Morphometric analysis.

Journal Article J Appl Physiol (1985) · August 1997 Hyperoxia damages lung parenchyma via increased cellular production of reactive oxygen species that exceeds antioxidant defenses. We hypothesized that aerosolized human recombinant manganese superoxide dismutase (rhMnSOD) would augment extracellular antiox ... Full text Link to item Cite

Iron accumulation in lung allografts after transplantation.

Journal Article Chest · August 1997 Lung transplantation has become a therapeutic option for end-stage pulmonary diseases, but after transplantation, infections and obliterative bronchiolitis (OB) are major causes of long-term morbidity and mortality. OB is a fibroproliferative disease, of p ... Full text Link to item Cite

Protection of perfused lung from oxidant injury by inhibitors of anion exchange

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY · August 1, 1997 Link to item Cite

Selective O-desulfation produces nonanticoagulant heparin that retains pharmacological activity in the lung.

Journal Article J Pharmacol Exp Ther · July 1997 Heparin has potential use as an antiinflammatory treatment in many lung diseases but its therapeutic use is limited by inherent anticoagulant activity. The anticoagulant nature of heparin can be eliminated by a number of chemical treatments, but often not ... Link to item Cite

Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient.

Journal Article Science · June 27, 1997 The binding of oxygen to heme irons in hemoglobin promotes the binding of nitric oxide (NO) to cysteinebeta93, forming S-nitrosohemoglobin. Deoxygenation is accompanied by an allosteric transition in S-nitrosohemoglobin [from the R (oxygenated) to the T (d ... Full text Link to item Cite

Hyperbaric oxygen improves tumor radiation response significantly more than carbogen/nicotinamide.

Journal Article Radiat Res · June 1997 This laboratory previously demonstrated that hyperbaric oxygen and hyperbaric carbogen improved oxygenation in the R3230Ac tumor, but normobaric 100% O2 and carbogen did not. The current study assessed tumor growth after exposure to radiation plus either h ... Link to item Cite

Changes in the lung after prolonged positive pressure ventilation in normal baboons.

Journal Article J Crit Care · June 1997 PURPOSE: The effects of prolonged positive pressure ventilation on lung ultrastructure are not well defined in primates. This study was designed to measure cardiopulmonary and morphological responses to 4 days of positive pressure ventilation in normal bab ... Full text Link to item Cite

Regulation of nitric oxide synthesis by oxygen in vascular endothelial cells.

Journal Article Am J Physiol · June 1997 Vascular endothelial cells synthesize nitric oxide (NO) in response to agonists that elevate cytosolic free Ca2+ concentrations. Once activated, NO synthase (NOS) requires arginine, NADPH, and O2 as cosubstrates. In this study, we investigated the role of ... Full text Link to item Cite

Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung.

Journal Article Am J Physiol · June 1997 Nitric oxide (NO.) has been proposed to modulate hypoxic vasoconstriction in the lung. The activity of nitric oxide synthase (NOS) can be inhibited by hypoxia because molecular oxygen is a necessary substrate for the enzyme. On the basis of this mechanism, ... Full text Link to item Cite

Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY · June 1, 1997 Link to item Cite

Regulation of nitric oxide synthesis by oxygen in vascular endothelial cells

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY · June 1, 1997 Link to item Cite

Hypothesis: iron chelation plays a vital role in neutrophilic inflammation.

Journal Article Biometals · April 1997 Neutrophil influx into tissues occurs in many diverse diseases and can be associated with both beneficial and injurious effects. We hypothesize that the stimulus for certain neutrophilic inflammatory responses can be reduced to a series of competing reacti ... Full text Link to item Cite

Release of cytochrome c from liver mitochondria during permeability transition.

Journal Article Biochem Biophys Res Commun · March 27, 1997 The mitochondrial permeability transition (PT) follows opening of megachannels in the inner membrane and may be part of a programmed death pathway. Recently a role for cytochrome c in programmed cell death has been proposed, although its relationship to PT ... Full text Link to item Cite

Production of hydroxyl radical in the hippocampus after CO hypoxia or hypoxic hypoxia in the rat.

Journal Article Free Radic Biol Med · 1997 Carbon monoxide poisoning produces both immediate and delayed neuronal injury in selective regions of the brain that is not readily explained on the basis of tissue hypoxia. One possibility is that cellular injury during and after CO poisoning is related t ... Full text Link to item Cite

Central nervous system oxygen toxicity during hyperbaric treatment of patients with carbon monoxide poisoning.

Journal Article Undersea Hyperb Med · December 1996 Hyperbaric oxygen (HBO2) is associated with a recognized risk for clinical central nervous system (CNS) toxicity. The risk for oxygen convulsions during routine hyperbaric treatment of most routine conditions is extremely low. Previous observations have su ... Link to item Cite

Near-infrared spectroscopy. Clinical applications.

Journal Article Crit Care Clin · October 1996 NIRS is an attractive monitoring technology because it is a noninvasive, real-time, repeatable method that allows for regional assessment of the adequacy of tissue oxygenation. It is able to evaluate the oxygenation state of hemoglobin in tissue and redox ... Full text Link to item Cite

Tyloxapol inhibits NF-kappa B and cytokine release, scavenges HOCI, and reduces viscosity of cystic fibrosis sputum.

Journal Article Am J Respir Crit Care Med · September 1996 Cystic fibrosis (CF) patients develop progressive cytokine-mediated inflammatory lung disease, with abundant production of thick, tenacious, protease- and oxidant-rich purulent airway secretions that are difficult to clear even with physiotherapy. In the s ... Full text Link to item Cite

VA/Q abnormalities during gram negative sepsis.

Journal Article Respir Physiol · August 1996 Hypoxemia in bacterial sepsis develops by mechanisms which are incompletely understood. In this study, we measured pulmonary gas exchange in eight baboons to determine the causes of hypoxemia after infusion of live Escherichia coli (1 x 10(10) CFU/kg) foll ... Full text Link to item Cite

O=O NO: it's CO.

Journal Article J Clin Invest · May 15, 1996 Full text Link to item Cite

Ultrastructural changes in skeletal muscle mitochondria in gram-negative sepsis.

Journal Article Shock · May 1996 Energy metabolism during sepsis is incompletely understood, but alterations in mitochondrial structure and function appear important. We measured time-dependent changes in mitochondrial structure during sepsis using serial skeletal muscle biopsies in anest ... Full text Link to item Cite

Glutathione depletion in epithelial lining fluid of lung allograft patients.

Journal Article Am J Respir Crit Care Med · February 1996 The lower respiratory tract is protected against reactive oxygen species (ROS) by a complex antioxidant system. In the epithelial lining fluid (ELF), glutathione (L-alpha-glutamyl-L-cysteinylglycine, GSH) is essential for adequate protection of pneumocytes ... Full text Link to item Cite

Mitochondrial generation of reactive oxygen species after brain ischemia in the rat.

Journal Article Stroke · February 1996 BACKGROUND AND PURPOSE: Brain mitochondria have a substantial capacity to generate reactive oxygen species after ischemia when the components of the respiratory chain are reduced and molecular oxygen is present. We tested the hypothesis that brain mitochon ... Full text Link to item Cite

Composition of lung lavage in pulmonary alveolar microlithiasis.

Journal Article Respiration · 1996 A case of pulmonary alveolar microlithiasis (PAM) is reported wherein total lung lavage was performed for relief of dyspnea. Characterization of the lavage material and examination of the microliths isolated from the lavage fluid confirmed previous reports ... Full text Link to item Cite

Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats.

Journal Article J Cereb Blood Flow Metab · January 1996 Selective neuronal cell death in the CA1 pyramidal cells of the hippocampus and neurons of the dorsolateral striatum as a consequence of brain ischemia/reperfusion (IR) can be ameliorated with brain hypothermia. Since postischemic injury is mediated partia ... Full text Link to item Cite

Differential expression of lung arginase and inos in sepsis

Journal Article Journal of Investigative Medicine · January 1, 1996 The primary metabolic fates of L-arginine are conversion to L-citrulline by nitric oxide synthase(NOS) and conversion to L-ornithine by arginase. In the lung, the expression of the inducible form of NOS (iNOS) is enhanced in various states of inflammation, ... Cite

Humic-like substances in air pollution particulates correlate with concentrations of transition metals and oxidant generation

Journal Article Inhalation Toxicology · January 1, 1996 We tested the hypotheses that (1) an incomplete oxidation of carbon- based fossil fuels during their combustion produces humic-like substances (HLS), which can be present in air pollution particulates and confer a capacity to complex metals; (2) air pollut ... Full text Cite

Inhibition of nitric oxide synthase on brain oxygenation in anesthetized rats exposed to hyperbaric oxygen.

Journal Article Undersea Hyperb Med · December 1995 Nitric oxide (NO) production is involved in the development of oxygen toxicity of the central nervous system (CNS) since inhibition of nitric oxide synthase (NOS) significantly protects animals from hyperbaric oxygen (HBO)-mediated convulsions. One potenti ... Link to item Cite

Nitration of tyrosine by hydrogen peroxide and nitrite.

Journal Article Free Radic Res · December 1995 Peroxynitrite anion is a powerful oxidant which can initiate nitration and hydroxylation of aromatic rings. Peroxynitrite can be formed in several ways, e.g. from the reaction of nitric oxide with superoxide or from hydrogen peroxide and nitrite at acidic ... Full text Link to item Cite

The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation.

Journal Article Br J Cancer · November 1995 Hyperbaric oxygen (HBO) has been proposed to reduce tumour hypoxia by increasing the amount of dissolved oxygen in the plasma. That this actually occurs has not been verified experimentally. This study was performed to explore changes in tumour oxygenation ... Full text Link to item Cite

Oxidative metabolism in sepsis and sepsis syndrome.

Journal Article J Crit Care · September 1995 The high mortality associated with sepsis syndrome and multiple organ dysfunction syndrome has persisted despite extraordinary research efforts in the laboratory and the intensive care unit. These syndromes produce systemic tissue damage that is likely to ... Full text Link to item Cite

Artificial surfactant attenuates hyperoxic lung injury in primates. I. Physiology and biochemistry.

Journal Article J Appl Physiol (1985) · May 1995 Prolonged exposure to O2 causes diffuse alveolar damage and surfactant dysfunction that contribute to the pathophysiology of hyperoxic lung injury. We hypothesized that exogenous surfactant would improve lung function during O2 exposure in primates. Sixtee ... Full text Link to item Cite

Artificial surfactant attenuates hyperoxic lung injury in primates. II. Morphometric analysis.

Journal Article J Appl Physiol (1985) · May 1995 Diffuse lung injury from hyperoxia is accompanied by low compliance and hypoxemia with disruption of endothelial and alveolar epithelial cell layers. Because both function and content of surfactant in diffuse lung injury decrease in animals and in humans, ... Full text Link to item Cite

L-arginine enhances injury in the isolated rabbit lung during hyperoxia.

Journal Article Respir Physiol · April 1995 L-Arginine is the substrate for synthesis of nitric oxide (NO.) by NO synthase which physiologically produces vasodilation. The reaction of NO. or its metabolites with O2 or its metabolites, however, can produce toxic reactive species which may cause cellu ... Full text Link to item Cite

Hydroxyl radical production in the brain after CO hypoxia in rats.

Journal Article Free Radic Biol Med · March 1995 Reactive oxygen species (ROS) have been implicated in the pathogenesis of neuronal injury after carbon monoxide (CO) poisoning. Severe CO poisoning is treated with hyperbaric oxygen (HBO), which eliminates CO quickly from hemoglobin and body tissue stores, ... Full text Link to item Cite

Brain computerized tomography after hyperbaric oxygen therapy for carbon monoxide poisoning.

Journal Article Undersea Hyperb Med · March 1995 The role of brain computerized tomography (CT) imaging in predicting clinical outcome was investigated in patients receiving hyperbaric oxygen therapy for serious carbon monoxide (CO) poisoning. From a series of 48 consecutive patients suffering loss of co ... Link to item Cite

Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion.

Journal Article Stroke · February 1995 BACKGROUND AND PURPOSE: Transient cerebral ischemia in rats results in selective loss of neuronal viability, eg, hippocampal CA1 neurons. The neurochemical variables responsible for this selective vulnerability to ischemia/reperfusion (IR) appear to involv ... Full text Link to item Cite

Reactive oxygen species produced by liver mitochondria of rats in sepsis.

Journal Article Arch Biochem Biophys · January 10, 1995 Reactive oxygen species (ROS) can be generated in experimental shock states through several different mechanisms. We measured ROS production in metabolically active liver mitochondria from rats rendered septic by cecal ligation and puncture. By polarograph ... Full text Link to item Cite

Progressive alveolar septal injury in primates exposed to 60% oxygen for 14 days.

Journal Article Am J Physiol · December 1994 Moderate exposures to hyperoxia are becoming increasingly common in clinical medicine as advancing technology allows O2 to be more effectively delivered to nonintubated patients. The sensitivity of the lung to injury by a subchronic exposure to 60% O2 was ... Full text Link to item Cite

PROGRESSIVE ALVEOLAR SEPTAL INJURY IN PRIMATES EXPOSED TO 60-PERCENT OXYGEN FOR 14 DAYS

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY · December 1, 1994 Link to item Cite

Synthetic surfactant scavenges oxidants and protects against hyperoxic lung injury.

Journal Article J Appl Physiol (1985) · September 1994 Injury and mortality after exposure to 100% oxygen can be diminished by surfactants that may operate by mechanisms other than those responsible for surface tension effects. We tested the hypotheses that 1) synthetic surfactant and its components function a ... Full text Link to item Cite

Prolonged production of hydroxyl radical in rat hippocampus after brain ischemia-reperfusion is decreased by 21-aminosteroids.

Journal Article Neurosci Lett · August 15, 1994 Transient global ischemia may lead to persistent production of reactive oxygen species in selected brain regions thereby contributing to selective vulnerability to ischemia. Using cerebral microdialysis, we assessed the production of the highly reactive hy ... Full text Link to item Cite

Altered mitochondrial redox responses in gram negative septic shock in primates.

Journal Article Circ Shock · May 1994 Gram negative sepsis causes changes in oxygen supply-demand relationships. We have used a primate model of hyperdynamic gram negative sepsis produced by intravenous infusion of Escherichia coli (E. coli) to evaluate sepsis-induced alterations in mitochondr ... Link to item Cite

Natural surfactant and hyperoxic lung injury in primates. I. Physiology and biochemistry.

Journal Article J Appl Physiol (1985) · March 1994 Surfactant dysfunction contributes to the pathophysiology of adult respiratory distress syndrome (ARDS), and we hypothesized that surfactant treatment would improve experimental ARDS produced by continuous exposure to hyperoxia. Twelve healthy male baboons ... Full text Link to item Cite

Isolation of mycobacteria in patients with pulmonary alveolar proteinosis.

Journal Article Medicine (Baltimore) · March 1994 Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by accumulation of proteinaceous material in the alveoli of affected individuals. Pulmonary infections appear to develop with increased frequency in these patients. The increased rate of ... Full text Link to item Cite

Natural surfactant and hyperoxic lung injury in primates. II. Morphometric analyses.

Journal Article J Appl Physiol (1985) · March 1994 Diffuse lung injury is accompanied by low compliance and hypoxemia with histological evidence of endothelial and alveolar epithelial cell disruption. The histological effects of treatment of an acute diffuse lung injury with a natural surfactant product we ... Full text Link to item Cite

Superoxide dismutase potentiates platelet-activating factor-induced injury in perfused lung.

Journal Article Am J Physiol · March 1994 Platelet-activating factor (PAF) causes pulmonary hypertension and lung edema in animals and isolated perfused lungs by poorly understood mechanisms. Because oxidative mechanisms have been implicated in PAF-mediated cellular injury, we tested the hypothesi ... Full text Link to item Cite

Bactericidal antibiotics increase tumor necrosis factor-alpha and cardiac output in rats after cecal ligation and puncture.

Journal Article Circ Shock · February 1994 We hypothesized that treatment of experimental sepsis with bactericidal antibiotics, known to enhance microbial toxin release, would alter tumor necrosis factor-alpha production and the hemodynamic response to the syndrome. In the rat, after cecal ligation ... Link to item Cite

Tumor necrosis factor-alpha-induced lung injury and its modulation by synthetic polynucleotide: a physiologic-morphometric analysis.

Journal Article Exp Lung Res · 1994 PolyI:C, a potent interferon (IFN) inducer, protects the isolated perfused lung (IPL) against platelet-activating factor (PAF)-induced injury. Because the release of PAF is stimulated by tumor necrosis factor (TNF), this study was designed to measure the e ... Full text Link to item Cite

SURFACTANT TREATMENT OF PRIMATE LUNG OXYGEN-TOXICITY

Conference LUNG SURFACTANT: BASIC RESEARCH IN THE PATHOGENESIS OF LUNG DISORDERS · January 1, 1994 Link to item Cite

Myocardial oxygenation in dogs during partial and complete coronary artery occlusion.

Journal Article Circ Res · September 1993 Regional myocardial oxygenation was assessed during partial and complete coronary artery occlusion using near infrared spectroscopy. In eight open-chest dogs, partial occlusions resulting in an approximately 42% decrease in left anterior descending coronar ... Full text Link to item Cite

PO2-dependent hydroxyl radical production during ischemia-reperfusion lung injury.

Journal Article Am J Physiol · September 1993 Pulmonary ischemia-reperfusion results in transient hypertension and edema formation. Implicated in this injury are partially reduced oxygen species including the highly reactive hydroxyl radical. We measured ischemia-reperfusion injury and hydroxyl radica ... Full text Link to item Cite

PO2-DEPENDENT HYDROXYL RADICAL PRODUCTION DURING ISCHEMIA-REPERFUSION LUNG INJURY

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY · September 1, 1993 Link to item Cite

Effects of muscle contraction on cytochrome a,a3 redox state.

Journal Article J Appl Physiol (1985) · August 1993 The relationships among mitochondrial O2 availability, O2 delivery, and lactate formation in exercising skeletal muscle remain unclear. Some data suggest that muscle O2 provision is sufficient at maximal O2 consumption (VO2max) to challenge the concept of ... Full text Link to item Cite

Cold-induced brain edema in mice. Involvement of extracellular superoxide dismutase and nitric oxide.

Journal Article J Biol Chem · July 25, 1993 The role of extracellular superoxide in the pathogenesis of vasogenic edema was studied using transgenic mice expressing a 5-fold increase in extracellular superoxide dismutase (EC-SOD) activity in their brains. Increased EC-SOD expression offered signific ... Link to item Cite

Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia.

Journal Article Neurosci Lett · July 23, 1993 The effects of nitric oxide synthase (NOS) inhibition on extracellular glutamate release were investigated in rats during global brain ischemia and reperfusion (IR) using cerebral microdialysis. A dialysis probe was inserted into the hippocampus of anesthe ... Full text Link to item Cite

Pulmonary drug toxicity in patients with primary breast cancer treated with high-dose combination chemotherapy and autologous bone marrow transplantation.

Journal Article Am Rev Respir Dis · May 1993 A protocol consisting of standard-dose adjuvant chemotherapy, high-dose combination alkylating agent chemotherapy, and autologous bone marrow transplant (ABMT) used at our institution for patients with primary breast cancer and extensive axillary lymph nod ... Full text Link to item Cite

SYNTHETIC SURFACTANT DIMINISHES OXIDANT GENERATION INVITRO

Journal Article AMERICAN REVIEW OF RESPIRATORY DISEASE · April 1, 1993 Link to item Cite

EVOLUTION OF HEMODYNAMICS AND V(A)/Q-DISTRIBUTIONS IN GRAM-NEGATIVE SEPSIS IN NONHUMAN-PRIMATES

Journal Article AMERICAN REVIEW OF RESPIRATORY DISEASE · April 1, 1993 Link to item Cite

ALTERED MITOCHONDRIAL REDOX RESPONSES IN GRAM-NEGATIVE SEPTIC SHOCK IN PRIMATES

Journal Article AMERICAN REVIEW OF RESPIRATORY DISEASE · April 1, 1993 Link to item Cite

MORPHOMETRIC ANALYSIS OF MUSCLE MITOCHONDRIAL CHANGES IN SEPSIS

Journal Article AMERICAN REVIEW OF RESPIRATORY DISEASE · April 1, 1993 Link to item Cite

Cerebral amino acid, norepinephrine and nitric oxide metabolism in CNS oxygen toxicity.

Journal Article Brain Res · March 19, 1993 CNS oxygen (O2) toxicity is complex, and the etiology of its most severe manifestation, O2 convulsions, is yet to be determined. A role for depletion of the brain GABA pool has been proposed, although recent data have implicated production of reactive O2 s ... Full text Link to item Cite

EFFECT OF HYPERBARIC-OXYGEN ON MUSCLE OXYGEN-TENSIONS

Conference FASEB JOURNAL · February 19, 1993 Link to item Cite

Protection against platelet-activating factor-induced injury by interferon inducer in perfused rabbit lung.

Journal Article J Appl Physiol (1985) · January 1993 Platelet-activating factor (PAF) and the interferons (IFN) are released during sepsis and the adult respiratory distress syndrome. The proinflammatory nature of PAF and anti-inflammatory property of IFN led us to investigate interactions between these two ... Full text Link to item Cite

PO2-dependent hydroxyl radical production during ischemia-reperfusion lung injury

Journal Article American Journal of Physiology - Lung Cellular and Molecular Physiology · 1993 Pulmonary ischemia-reperfusion results in transient hypertension and edema formation. Implicated in this injury are partially reduced oxygen species including the highly reactive hydroxyl radical. We measured ischemia- reperfusion injury and hydroxyl radic ... Cite

Hydrogen peroxide production by monoamine oxidase during ischemia-reperfusion in the rat brain.

Journal Article J Cereb Blood Flow Metab · January 1993 Monoamine oxidase (MAO) as a source of hydrogen peroxide (H2O2) was evaluated during ischemia-reperfusion in vivo in the rat brain. H2O2 production was assessed with and without inhibition of MAO during and after 15 min of ischemia. Metabolism of H2O2 by c ... Full text Link to item Cite

Generation of hydroxyl radical by crocidolite asbestos is proportional to surface [Fe3+].

Journal Article Arch Biochem Biophys · November 1, 1992 Differences among fibrous silicates to effect injury in biological systems have been postulated to reflect oxidant generation by structural iron within the crystal lattice of amphiboles. Iron is also coordinated to the surface of all silicates in concentra ... Full text Link to item Cite

Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity.

Journal Article Proc Natl Acad Sci U S A · October 15, 1992 Although reactive O2 species appear to participate in central nervous system (CNS) O2 toxicity, the exact roles of different reactive O2 species are undetermined. To study the contribution of extracellular superoxide anion (O2-) to CNS O2 toxicity we const ... Full text Link to item Cite

Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain.

Journal Article J Clin Invest · October 1992 To better understand the mechanisms of tissue injury during and after carbon monoxide (CO) hypoxia, we studied the generation of partially reduced oxygen species (PROS) in the brains of rats subjected to 1% CO for 30 min, and then reoxygenated on air for 0 ... Full text Link to item Cite

Warehouse workers' headache.

Journal Article J Occup Med · September 1992 Link to item Cite

WAREHOUSE WORKERS HEADACHE - REPLY

Journal Article JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE · September 1, 1992 Link to item Cite

Effects of inhibition and induction of cytochrome P-450 isozymes on hyperoxic lung injury in rats.

Journal Article Am J Respir Cell Mol Biol · August 1992 Pulmonary oxygen toxicity most likely results from excessive production of reactive oxygen species. The role of the cytochromes P-450 in this process is controversial because these enzymes have been reported both to enhance hyperoxic lung injury and to pro ... Full text Link to item Cite

Pulmonary oxalate deposition associated with Aspergillus niger infection. An oxidant hypothesis of toxicity.

Journal Article Am Rev Respir Dis · June 1992 Tissue injury by Aspergillus niger infection is associated with the deposition of calcium oxalate crystals. Oxalate is recognized to function as a ligand for numerous metal cations and will react with ferric ion to form a coordination complex. We describe ... Full text Link to item Cite

Comparison of systemic oxygen delivery and uptake with NIR spectroscopy of brain during normovolemic hemodilution in the rabbit.

Journal Article Resuscitation · February 1992 Incremental hyperoxic normovolemic hemodilution was utilized to progressively decrease oxygen delivery (DO2) in anesthetized rabbits. At decreasing DO2, we compared systemic responses related to the adequacy of DO2, i.e. mixed venous oxygen saturation (SvO ... Full text Link to item Cite

Recovery of energy metabolism in rat brain after carbon monoxide hypoxia.

Journal Article J Clin Invest · February 1992 Carbon monoxide (CO) may inhibit mitochondrial electron transport in the brain and increase the toxic effects of the gas. This hypothesis was investigated in anesthetized rats during CO exposure and recovery at either normobaric or hyperbaric O2 concentrat ... Full text Link to item Cite

Warehouse workers’ headache: The author replies

Journal Article Journal of Occupational Medicine · January 1, 1992 Cite

Warehouse workers' headache. Carbon monoxide poisoning from propane-fueled forklifts.

Journal Article J Occup Med · January 1992 We reviewed over 220 cases of acute carbon monoxide (CO) poisoning and now report on 17 patients whose poisoning occurred from the indoor use of propane-fueled forklifts. All patients in this series presented with neurologic symptoms or persistent headache ... Link to item Cite

Responses of baboons to prolonged hyperoxia: physiology and qualitative pathology.

Journal Article J Appl Physiol (1985) · December 1991 Cardiopulmonary responses to prolonged hyperoxia and their relationships to the development of lung pathology have not been fully characterized in primates. In this study, circulatory hemodynamics and pulmonary function, vascular permeability, and leukocyt ... Full text Link to item Cite

Initial treatment of patients with extensive trauma.

Journal Article N Engl J Med · November 14, 1991 Full text Link to item Cite

Recovery of cerebral metabolism and mitochondrial oxidation state is delayed after hypothermic circulatory arrest.

Journal Article Circulation · November 1991 To study the effect of deep hypothermic cardiopulmonary bypass and total circulatory arrest on cerebral metabolism and oxygenation, we measured the cerebral metabolic rate for oxygen (CMRO2) and assessed brain oxygenation by near infrared spectroscopy befo ... Link to item Cite

Differential pathlength factor for diffuse photon scattering through tissue by a pulse-response method.

Journal Article Math Biosci · November 1991 Although near-infrared (NIR) spectroscopy may one day provide a noninvasive measurement of oxidative metabolism in tissue, the method cannot be fully quantitative until the mean pathlength traveled by photons between reference and output detectors (i.e, op ... Full text Link to item Cite

Prevention of H2O2 generation by monoamine oxidase protects against CNS O2 toxicity.

Journal Article J Appl Physiol (1985) · September 1991 Toxicity to the central nervous system (CNS) by hyperbaric oxygen (HBO) presumably relates to increased production of reactive oxygen species. The sites of generation of reactive oxygen species during HBO, however, have not been fully characterized in the ... Full text Link to item Cite

Venous gas emboli and complement activation after deep repetitive air diving.

Journal Article Undersea Biomed Res · July 1991 Complement activity has been linked to decompression sickness (DCS), but the effects of intravascular bubbles on complement activation are poorly understood. We have investigated intravascular complement activation by measuring red blood cell (RBC)-bound C ... Link to item Cite

Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain.

Journal Article Stroke · February 1991 Proton magnetic resonance (MR) imaging has been recommended as a diagnostic tool for the detection of focal cerebral ischemia. We compared microscopic MR images of rat brains after focal cerebral ischemia with evidence of histological damage found on corre ... Full text Link to item Cite

MR imaging of microcirculation in rat brain: correlation with carbon dioxide-induced changes in blood flow.

Journal Article J Magn Reson Imaging · 1991 Considerable interest has been shown in developing a magnetic resonance (MR) imaging technique with quantitative capability in the evaluation of tissue microcirculation ("perfusion"). In the present study, the flow-dephased/flow-compensated (FD/FC) techniq ... Full text Link to item Cite

Prevention of H2O2 generation by monoamine oxidase protects against CNS O2 toxicity

Journal Article Journal of Applied Physiology · 1991 Toxicity to the central nervous system (CNS) by hyperbaric oxygen (HBO) presumably relates to increased production of reactive oxygen species. The sites of generation of reactive oxygen species during HBO, however, have not been fully characterized in the ... Cite

Regional H2O2 concentration in rat brain after hyperoxic convulsions.

Journal Article J Appl Physiol (1985) · November 1990 O2 toxicity of the central nervous system (CNS) may be a result of enhanced generation of reactive O2 species such as superoxide and H2O2 at high PO2. In this study, we measured H2O2 production in six regions of the rat brain before and after convulsions i ... Full text Link to item Cite

Dynamic mechanisms of cardiac oxygenation during brief ischemia and reperfusion.

Journal Article Am J Physiol · November 1990 Myocardial oxygenation may be altered markedly by changes in tissue blood flow. During brief ischemia and reperfusion produced by transient occlusion of the left anterior descending artery in 10 open-chest dogs, changes in the oxygenation of tissue hemoglo ... Full text Link to item Cite

DYNAMIC MECHANISMS OF CARDIAC OXYGENATION DURING BRIEF ISCHEMIA AND REPERFUSION

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY · November 1, 1990 Link to item Cite

Cerebral oxygen availability by NIR spectroscopy during transient hypoxia in humans.

Journal Article J Appl Physiol (1985) · September 1990 The effects of mild hypoxia on brain oxyhemoglobin, cytochrome a,a3 redox status, and cerebral blood volume were studied using near-infrared spectroscopy in eight healthy volunteers. Incremental hypoxia reaching 70% arterial O2 saturation was produced in n ... Full text Link to item Cite

Near-infrared optical responses in feline brain and skeletal muscle tissues during respiratory acid-base imbalance.

Journal Article Brain Res · June 11, 1990 The effects of hyper- and hypocapnia on oxidative metabolism were evaluated by near-infrared (NIR) multiwavelength spectroscopy in intact brain and skeletal muscle tissues of the anesthetized cat. A 3-wavelength NIR algorithm was used to monitor cytochrome ... Full text Link to item Cite

In vivo binding of carbon monoxide to cytochrome c oxidase in rat brain.

Journal Article J Appl Physiol (1985) · February 1990 The possibility of binding of CO to cytochrome c oxidase (cytochrome a,a3) in brain cortex has been examined in vivo by reflectance spectrophotometry. During ventilation with CO-containing gases, cytochrome a,a3 absorption at 605 nm increased in the pariet ... Full text Link to item Cite

In vivo responses of mitochondrial redox levels to Eschericia coli bacteremia in primates

Journal Article Journal of Critical Care · January 1, 1990 Septic shock is characterized by multifactorial and interrelated defects in hemodynamic function and metabolism. Systemic derangements in hemodynamic parameters, oxygen uptake, and substrate preference at various stages of septic shock have been characteri ... Full text Cite

Eicosanoids and the hemodynamic course of live Escherichia coli-induced sepsis in baboons.

Journal Article Circ Shock · November 1989 Time-related changes in eicosanoid release and hemodynamic parameters were characterized in baboons during the early development of sepsis induced by intravenous (i.v.) infusion of live Escherichia coli (4 x 10(10) organisms/kg) in baboons. Plasma levels o ... Link to item Cite

HYPERBARIC OXYGEN FOR CARBON MONOXIDE POISONING

Journal Article The Lancet · October 28, 1989 Full text Cite

Hyperbaric for carbon monoxide poisoning.

Journal Article Lancet · October 28, 1989 Link to item Cite

The authors reply

Journal Article Critical Care Medicine · August 1989 Full text Cite

Spectrophotometry of b-type cytochromes in rat brain in vivo and in vitro.

Journal Article Am J Physiol · April 1989 Terminal oxidase inhibitors such as cyanide (CN) and carbon monoxide (CO) produce different absorption changes in the intact brain, suggesting different mitochondrial responses to the inhibitors. In the present study, the nature of the cytochromes involved ... Full text Link to item Cite

Should hyperbaric oxygen be used to treat the pregnant patient for acute carbon monoxide poisoning? A case report and literature review.

Journal Article JAMA · February 17, 1989 Carbon monoxide (CO) is the leading cause of death due to poisoning. Although uncommon, CO poisoning does occur during pregnancy and can result in fetal mortality and neurological malformations in fetuses who survive to term. Uncertainty arises regarding t ... Full text Link to item Cite

Spectrophotometry of b-type cytochromes in rat brain in vivo and in vitro

Journal Article American Journal of Physiology - Cell Physiology · January 1, 1989 Terminal oxidase inhibitors such as cyanide (CN) and carbon monoxide (CO) produce different absorption changes in the intact brain, suggesting different mitochondrial responses to the inhibitors. In the present study, the nature of the cytochromes involved ... Cite

Reversal of carbon monoxide-cytochrome c oxidase binding by hyperbaric oxygen in vivo.

Journal Article Adv Exp Med Biol · 1989 Cytochrome a,a3 redox state of the parietal cortex of pentobarbital anesthetized rats was continuously monitored through intact skull with four wavelength differential spectrophotometry during exposure to 90% O2 plus either 1.0 or 0.5% CO at 1 and 3 (ATA). ... Full text Link to item Cite

Behavior of the copper band of cytochrome c oxidase in rat brain during FC-43-for-blood substitution.

Journal Article Adv Exp Med Biol · 1989 FC-43-for-blood substitution experiments were conducted in anesthetized rats to evaluate NIR spectroscopic responses by living brain to exchange transfusion at very low hematocrits. The NIR responses to the exchange process also assess the ability of multi ... Full text Link to item Cite

Intracellular monitoring of experimental respiratory failure. Collaborative Group on Intracellular Monitoring.

Journal Article Am Rev Respir Dis · August 1988 The view that intracellular changes during oxygen depletion are the primary cause of abnormal function and altered physiology was originally proposed by Paul Bert. From that time it remains a basic assumption that hypoxia in intact animals produces alterat ... Full text Link to item Cite

Direct effects of CO on cerebral energy metabolism in bloodless rats.

Journal Article J Appl Physiol (1985) · August 1988 Cerebrocortical b-cytochromes have been found to be sensitive to reduction in the presence of CO and O2 in vivo. CO-mediated cytochrome b reduction responses in "bloodless" rats were correlated in this study with changes in concentrations of high energy an ... Full text Link to item Cite

Prognosis of patients with cirrhosis and chronic liver disease admitted to the medical intensive care unit.

Journal Article Crit Care Med · July 1988 Patients with hepatic failure admitted to the medical ICU (MICU) generally have a poor prognosis. To determine if there were readily identifiable clinical factors associated with a high predictive value for outcome, we reviewed retrospectively the charts o ... Full text Link to item Cite

Cyanide-related changes in cerebral O2 delivery and metabolism in fluorocarbon-circulated rats.

Journal Article Toxicol Appl Pharmacol · June 15, 1988 Cyanide-induced cytotoxicity is primarily a result of inhibition of O2 uptake by the terminal enzyme of the mitochondrial respiratory chain, cytochrome-c oxidase (cytochrome aa3). The oxidase in the brain is highly vulnerable to cyanide cytotoxicity, but f ... Full text Link to item Cite

Near infrared monitoring of human skeletal muscle oxygenation during forearm ischemia.

Journal Article J Appl Physiol (1985) · June 1988 Changes in tissue oxygenation of forearm muscles were measured by near infrared (NIR) spectrophotometry in 10 healthy adults during tourniquet ischemia and venous outflow restriction. Muscle O2 stores were depleted rapidly by forearm ischemia manifest by a ... Full text Link to item Cite

Interstitial lung disease and domestic wood burning.

Journal Article Am Rev Respir Dis · May 1988 A 61-yr-old woman was evaluated for dyspnea on exertion and interstitial lung disease. A unique association between inhaled particulates from wood burning and interstitial pneumonitis was demonstrated. Bronchoalveolar lavage revealed numerous particulates ... Full text Link to item Cite

O2 dependence of in vivo brain cytochrome redox responses and energy metabolism in bloodless rats.

Journal Article J Cereb Blood Flow Metab · April 1988 Oxygen-dependent changes in brain cytochrome redox state and cerebrocortical energy metabolism were evaluated in fluorocarbon-circulated rats at hematocrits of less than 1%. Redox levels of three respiratory chain cytochrome complexes, b, c, and a,a3 (cyto ... Full text Link to item Cite

Effect of fluorocarbon-for-blood exchange on regional cerebral blood flow in rats.

Journal Article Am J Physiol · April 1988 Cerebrocirculatory responses to total perfluorocarbon (FC-43)-for-blood replacement (Hct less than 1%) were studied in anesthetized, ventilated rats breathing 100% O2. Changes in total and regional cerebral blood flow (CBF) were measured using the radiolab ... Full text Link to item Cite

EFFECT OF FLUOROCARBON-FOR-BLOOD EXCHANGE ON REGIONAL CEREBRAL BLOOD-FLOW IN RATS

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY · April 1, 1988 Link to item Cite

Near-infrared monitoring of cerebral oxygen sufficiency. I. Spectra of cytochrome c oxidase.

Journal Article Neurol Res · March 1988 Near-infrared (NIR) difference spectra were obtained for oxidized cytochrome c oxidase of isolated mitochondria in vitro and of cerebral tissue in situ observed through scalp and skull. The broad peaks of maximal absorption observed in both were not incons ... Full text Link to item Cite

Effect of fluorocarbon-for-blood exchange on regional cerebral blood flow in rats

Journal Article American Journal of Physiology - Heart and Circulatory Physiology · January 1, 1988 Cerebrocirculatory responses to total perfluorocarbon (FC-43)-for-blood replacement (Hct < 1%) were studied in anesthetized, ventilated rats breathing 100% O2. Changes in total and regional cerebral blood flow (CBF) were measured using the radiolabeled-mic ... Cite

O2 dependence of in vivo brain cytochrome redox responses and energy metabolism in bloodless rats

Journal Article Journal of Cerebral Blood Flow and Metabolism · 1988 Oxygen-dependent changes in brain cytochrome redox state and cerebrocortical energy metabolism were evaluated in fluorocarbon-circulated rats at hematocrits of <1%. Redox levels of three respiratory chain cytochrome complexes, b, c, and a,a3 (cytochrome ... Cite

Perflouorochemicals: Brain Oxygen Metabolism In Fluosol-43 Circulated Rats

Journal Article Biomaterials, Artificial Cells and Artificial Organs · January 1, 1988 Full text Cite

Skeletal muscle oxygen availability during respiratory acid-base disturbances in cats.

Journal Article Respir Physiol · November 1987 Respiratory acid-base disorders elicit physiological responses that alter O2 delivery to various tissues. We have used a near infrared (NIR) optical technique to monitor cytochrome a,a3 oxidation state, tissue O2 store (relative hemoglobin plus myoglobin o ... Full text Link to item Cite

Differences in brain cytochrome responses to carbon monoxide and cyanide in vivo.

Journal Article J Appl Physiol (1985) · March 1987 Cytochrome oxidation-reduction responses to two mitochondrial electron transport inhibitors, carbon monoxide (CO) and cyanide (CN), were studied in the intact brains of fluorocarbon-circulated rats. In vivo reflectance spectrophotometry indicated that cort ... Full text Link to item Cite

CEREBROCORTICAL ENERGY-METABOLISM, BLOOD-FLOW AND CYTOCHROME REDOX RESPONSES TO FC43 EXCHANGE IN RATS

Journal Article BIOMATERIALS ARTIFICIAL CELLS AND ARTIFICIAL ORGANS · January 1, 1987 Link to item Cite

OXYGEN-DEPENDENCE OF BRAIN CYTOCHROME REDOX STATES AND ENERGY-METABOLISM IN FLUOSOL-43 RATS

Journal Article BIOMATERIALS ARTIFICIAL CELLS AND ARTIFICIAL ORGANS · January 1, 1987 Link to item Cite

Near-infrared spectrophotometric monitoring of oxygen distribution to intact brain and skeletal muscle tissues.

Journal Article Crit Care Med · August 1986 During continuous near-infrared optical monitoring of brain cortex and hindlimb skeletal muscles, anesthetized, ventilated cats were exposed either to progressive alveolar hypoxia, or to acute hemorrhage followed in some cases by resuscitation. Hypoxia dec ... Full text Link to item Cite

Asbestos bodies in bronchoalveolar lavage fluid. A study of 20 asbestos-exposed individuals and comparison to patients with other chronic interstitial lung diseases.

Journal Article Acta Cytol · 1986 We studied the asbestos body (AB) content of bronchoalveolar lavage fluid from 20 patients with a history of occupational asbestos exposure, 31 patients with sarcoidosis and 5 patients with idiopathic pulmonary fibrosis. The cellular lavage pellet was dige ... Link to item Cite

Regional cerebral blood flow in normal blood circulated and perfluorocarbon transfused rats.

Journal Article Adv Exp Med Biol · 1986 Perfluorocarbon blood substitutes have been shown to exert a protective effect in animal models of cerebral ischemia. The mechanisms by which PFCs improve cerebral hemodynamics are uncertain, however decreased viscosity, small particle size and high oxygen ... Full text Link to item Cite

In vivo modulation of norepinephrine-induced cerebral oxygenation states by hypoxia and hyperoxia.

Journal Article Brain Res · July 15, 1985 The effect of intravenous norepinephrine (NE) administration on three O2-dependent parameters of cerebral oxygenation was studied in the parietal cortex of skull intact anesthetized rats. Reflectance spectrophotometry was used to measure in vivo changes in ... Full text Link to item Cite

Energy metabolism and in vivo cytochrome c oxidase redox relationships in hypoxic rat brain.

Journal Article Neurol Res · June 1985 Rats were subjected to graded arterial hypoxia while we measured changes in the oxidation level of cytochrome c oxidase (cytochrome aa3) in the brain by a non-invasive, optical technique. The experiments were terminated at different arterial oxygen tension ... Full text Link to item Cite

Carbon monoxide-cytochrome interactions in the brain of the fluorocarbon-perfused rat.

Journal Article J Appl Physiol (1985) · February 1985 Reflectance spectrophotometry through the skull was used to investigate carbon monoxide (CO) binding by tissue hemoproteins in the brains of barbiturate-anesthetized Sprague-Dawley rats. After splenectomy and extensive perfluorotributylamine exchange trans ... Full text Link to item Cite

Cerebral cytochrome a,a3 inhibition by cyanide in bloodless rats.

Journal Article Toxicology · October 1984 Brain cytochrome a,a3 inhibition is presumed to be the site of lethal histotoxic hypoxia in cyanide poisoning perhaps because of the relative inability of the brain to metabolize cyanide. However, only limited data are available about cyanide toxic effects ... Full text Link to item Cite

Spectrophotometry of cerebral cytochrome a, a3 in bloodless rats.

Journal Article Brain Res · July 2, 1984 Bloodless, anesthetized Sprague-Dawley rats produced by perfluorochemical exchange transfusion and splenectomy were used to obtain cerebral mitochondrial difference spectra directly through the skull by both reflectance and transmission spectrophotometry. ... Full text Link to item Cite

Ga-67 uptake in the lung in sarcoidosis.

Journal Article Radiology · February 1984 Images were obtained with Ga-67 and bronchopulmonary lavage performed in 21 patients with sarcoidosis (31 studies). The Ga-67 index, a semiquantitative criterion, was compared to a quantitative computer index based on lung:liver activity ratios; accuracy i ... Full text Link to item Cite

Cyanide-induced cytochrome a,a3 oxidation-reduction responses in rat brain in vivo.

Journal Article J Clin Invest · October 1983 The sensitivity of the brain to cyanide-induced histotoxic hypoxia and the protective effects of known cyanide antagonists, have been assessed in vivo by reflectance spectrophotometry. Cyanide-related changes in cytochrome a,a3 (cytochrome c oxidase) oxida ... Full text Link to item Cite

LOW OR ABSENT IMMUNOGLOBULINS AT THE BRONCHOALVEOLAR SURFACE IN PATIENTS WITH ASBESTOSIS

Journal Article AMERICAN REVIEW OF RESPIRATORY DISEASE · January 1, 1983 Link to item Cite

LAVAGE LYMPHOCYTE DIFFERENTIAL, PHYSIOLOGIC FUNCTION, AND CORTICOSTEROID-THERAPY IN SARCOIDOSIS

Journal Article AMERICAN REVIEW OF RESPIRATORY DISEASE · January 1, 1983 Link to item Cite

Serum ferritin increases during deep saturation dives.

Journal Article Aviat Space Environ Med · October 1982 Serum ferritin levels were determined in six U.S. Navy divers during a 29d helium-oxygen saturation dive. Progressive increases in serum ferritin were observed during compression. These increases were maintained during decompression and for 1 week postdive ... Link to item Cite

Equations for predicting diver regional skin temperatures as a function of mean skin temperature.

Journal Article Undersea Biomed Res · March 1982 A series of linear algebraic equations have been derived from those of Kerslake (Flying Personnel Research Committee Memo 213, R.A.F. Institute of Aviation Medicine, 1964) for predicting the regional skin temperatures of a quasi-euthermic diver having pron ... Link to item Cite

Metabolic response to respiratory heat loss-induced core cooling.

Journal Article J Appl Physiol Respir Environ Exerc Physiol · April 1981 To study the phenomenon of isolated core cooling, four resting men breathed cooled helium-oxygen (T in = 14 +/- 2 degrees C, 40-60% relative humidity) in a warm hyperbaric chamber at pressures equivalent to 640, 1,000, and 1,400, and 1,800 ft seawater (fsw ... Full text Link to item Cite

Calibration and characterization of heat flow transducers for use in hyperbaric helium.

Journal Article Undersea Biomed Res · December 1980 A calibration technique for heat flow transducers (HFT) verified to within 5% by the National Bureau of Standards was used to show significant errors in calibration constants supplied by the manufacturer of the transducers. The effects of variable ambient ... Link to item Cite

Thermal responses in humans exposed to cold hyperbaric helium-oxygen.

Journal Article J Appl Physiol Respir Environ Exerc Physiol · December 1980 The relationship of metabolic heat production to skin and core temperatures, cutaneous heat flow, and respiratory heat loss was measured in 10 male subjects cooled in hyperbaric helium at 20.7 ATA and 15 or 20 degrees C for 60-120 min. Under these conditio ... Full text Link to item Cite

Prolonged oxygen exposures in immersed exercising divers at 25 fsw (1.76 ATA).

Journal Article Undersea Biomed Res · December 1979 Twenty-four oxygen exposures lasting 80 to 271 min were performed by six immersed exercising subjects at 25 fsw (1.76 ATA) in both warm and cold water. Two types of exercise were performed, moderate work (50 watts) for long periods of time, and graded exer ... Link to item Cite

Breast carcinoma, thyroid carcinoma, and T3 thyrotoxicosis in a male cretin.

Journal Article Johns Hopkins Med J · June 1977 A male patient with clinical and radiographic evidence of cretinism was found to have T3 thyrotoxicosis. The cause was thought to be a well-differentiated follicular carcinoma of the thyroid. Although the disease was not documented, the patient probably ha ... Link to item Cite

Sequential activation of splenic nuclear RNA polymerases by erythropoietin.

Journal Article J Clin Invest · January 1976 The spleen of the ex-hypoxic polycythemic mouse was employed to study the effect of erythropoietin on nuclear RNA polymerase activity. On the basis of ionic strength requirements and sensitivity to the fungal toxin alpha-amanitin, two major forms (I and II ... Full text Link to item Cite