Scholars@Duke
James Michael Provenzale

James Michael Provenzale

Professor of Radiology
Radiology, Neuroradiology
prove001@mc.duke.edu
Box 3808 Med Ctr, Durham, NC 27710
1533 Hosp North, Durham, NC

Selected Publications

Severe CNS involvement in a subset of long-term treated children with infantile-onset Pompe disease.

Journal Article Mol Genet Metab · February 2024 INTRODUCTION: The standard of care for patients with infantile-onset Pompe disease (IOPD) is enzyme replacement therapy (ERT), which does not cross the blood brain barrier. While neuromuscular manifestations of IOPD are well-described, central nervous syst ... Full text Link to item Cite

Suggestions for improving the work culture in radiology: Advice from a famous basketball coach.

Journal Article Clin Imaging · March 2023 This manuscript addresses the issue of the need for improvement of the work culture in Radiology departments. The manuscript uses advice from the famous college basketball coach John Wooden to highlight the issues involved in the work culture environment i ... Full text Link to item Cite

Benefits of newborn screening and hematopoietic cell transplant in infantile Krabbe disease.

Journal Article Blood Adv · May 10, 2022 Infantile Krabbe disease (IKD) can be treated with hematopoietic cell transplantation (HCT) if done during the first weeks of life before symptoms develop. To facilitate this, newborn screening (NBS) has been instituted in 8 US states. An application to ad ... Full text Open Access Link to item Cite

Novel approaches to quantify CNS involvement in children with Pompe disease.

Journal Article Neurology · August 11, 2020 OBJECTIVE: To characterize the extent of CNS involvement in children with Pompe disease using brain MRI and developmental assessments. METHODS: The study included 14 children (ages 6-18 years) with infantile Pompe disease (IPD) (n = 12) or late-onset Pompe ... Full text Open Access Link to item Cite

Peering Into Peer Review: AJR Neuroradiology Reviewers Discuss Their Approaches to Assessing a Manuscript.

Journal Article AJR Am J Roentgenol · January 2020 OBJECTIVE. This article provides comments from a small group of highly qualified reviewers of the American Journal of Roentgenology (AJR) regarding their approach to assessing manuscripts. The objective is to educate authors about the issues to which revie ... Full text Link to item Cite

Lessons Learned From AJR Neuroradiology Manuscript Reviews: Informative Advice for Prospective Authors in All Fields of Radiology.

Journal Article AJR Am J Roentgenol · January 2020 OBJECTIVE. Comments from manuscript reviews are helpful for guiding a decision about publication and also afford a source of valuable information about how to improve a manuscript. This article is a compendium of comments from reviews of AJR Neuroradiology ... Full text Link to item Cite

A Shorter Invitation Period for AJR Manuscript Reviewers: Impact on Time to Completion of Reviews.

Journal Article AJR Am J Roentgenol · January 2020 OBJECTIVE. The objective of this article was to study the effect of decreasing the time allowed an American Journal of Roentgenology (AJR) reviewer to consider an invitation to review on time for two invitees to accept an invitation and time for both revie ... Full text Link to item Cite

Imaging Evaluation of the Adult Presenting With New-Onset Seizure.

Journal Article AJR Am J Roentgenol · January 2019 OBJECTIVE: The purpose of this study is to discuss the evidence supporting the use of neuroimaging in adult patients presenting with new-onset seizure. CONCLUSION: Unenhanced CT should be the initial imaging examination performed for adults presenting with ... Full text Link to item Cite

Analysis of variability of fractional anisotropy values at 3T using a novel diffusion tensor imaging phantom.

Journal Article Neuroradiol J · December 2018 We employed a novel diffusion tensor imaging phantom to study intra- and interscanner reproducibility on two 3T magnetic resonance (MR) scanners. Using a phantom containing thousands of hollow micron-size tubes in complex arrays, we performed two experimen ... Full text Link to item Cite

A Programme for Risk Assessment and Minimisation of Progressive Multifocal Leukoencephalopathy Developed for Vedolizumab Clinical Trials.

Journal Article Drug Saf · August 2018 INTRODUCTION: Over the past decade, the potential for drug-associated progressive multifocal leukoencephalopathy (PML) has become an increasingly important consideration in certain drug development programmes, particularly those of immunomodulatory biologi ... Full text Link to item Cite

Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages.

Journal Article Neuroradiol J · April 2018 Purpose The purpose of this study was to compare quantitative diffusion tensor imaging metrics in dogs affected with a model of Krabbe disease to age-matched normal controls. We hypothesized that fractional anisotropy would be decreased and radial diffusiv ... Full text Link to item Cite

Diffusion tensor imaging findings suggestive of white matter alterations in a canine model of mucopolysaccharidosis type I.

Journal Article Neuroradiol J · February 2018 Purpose We investigated fractional anisotropy (FA) and radial diffusivity (RD) in a canine model of mucopolysaccharidosis (MPS). We hypothesized that canines affected with MPS would exhibit decreased FA and increased RD values when compared to unaffected c ... Full text Link to item Cite

Magnetic resonance perfusion for differentiating low-grade from high-grade gliomas at first presentation.

Journal Article Cochrane Database Syst Rev · January 22, 2018 BACKGROUND: Gliomas are the most common primary brain tumour. They are graded using the WHO classification system, with Grade II-IV astrocytomas, oligodendrogliomas and oligoastrocytomas. Low-grade gliomas (LGGs) are WHO Grade II infiltrative brain tumours ... Full text Link to item Cite

Assessment of quantitative magnetic resonance imaging metrics in the brain through the use of a novel phantom.

Journal Article Brain Inj · 2018 OBJECTIVE: Multisite and longitudinal neuroimaging studies are important in uncovering trajectories of recovery and neurodegeneration following traumatic brain injury (TBI) and concussion through the use of diffusion tensor imaging (DTI) and other imaging ... Full text Link to item Cite

Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines.

Journal Article Neuroradiol J · October 2017 Purpose We compared fractional anisotropy and radial diffusivity measurements between pediatric canines affected with mucopolysaccharidosis I and pediatric control canines. We hypothesized that lower fractional anisotropy and higher radial diffusivity valu ... Full text Link to item Cite

Novel region of interest interrogation technique for diffusion tensor imaging analysis in the canine brain.

Journal Article Neuroradiol J · August 2017 Purpose We describe a novel technique for measuring diffusion tensor imaging metrics in the canine brain. We hypothesized that a standard method for region of interest placement could be developed that is highly reproducible, with less than 10% difference ... Full text Link to item Cite

Diffusion tensor imaging tensor shape analysis for assessment of regional white matter differences.

Journal Article Neuroradiol J · August 2017 Purpose The purpose of this study was to investigate a novel tensor shape plot analysis technique of diffusion tensor imaging data as a means to assess microstructural differences in brain tissue. We hypothesized that this technique could distinguish white ... Full text Link to item Cite

Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury.

Journal Article Epilepsia · June 2017 OBJECTIVE: Our aim was to explore the association between plasma cytokines and febrile status epilepticus (FSE) in children, as well as their potential as biomarkers of acute hippocampal injury. METHODS: Analysis was performed on residual samples of childr ... Full text Link to item Cite

Contemporary Imaging of Cerebral Arteriovenous Malformations.

Journal Article AJR Am J Roentgenol · June 2017 OBJECTIVE: Brain arteriovenous malformation (AVM) rupture results in substantial morbidity and mortality. The goal of AVM treatment is eradication of the AVM, but the risk of treatment must be weighed against the risk of future hemorrhage. CONCLUSION: Imag ... Full text Link to item Cite

Improving sensitivity and specificity of capturing and detecting targeted cancer cells with anti-biofouling polymer coated magnetic iron oxide nanoparticles.

Journal Article Colloids Surf B Biointerfaces · February 1, 2017 Detecting circulating tumor cells (CTCs) with high sensitivity and specificity is critical to management of metastatic cancers. Although immuno-magnetic technology for in vitro detection of CTCs has shown promising potential for clinical applications, the ... Full text Link to item Cite

Clinical outcomes of children with abnormal newborn screening results for Krabbe disease in New York State.

Journal Article Genet Med · December 2016 BACKGROUND: Early infantile Krabbe disease is rapidly fatal, but hematopoietic stem cell transplantation (HSCT) may improve outcomes if performed soon after birth. New York State began screening all newborns for Krabbe disease in 2006. METHODS: Infants wit ... Full text Open Access Link to item Cite

Diffusion tensor imaging analysis of the brain in the canine model of Krabbe disease.

Journal Article Neuroradiol J · December 2016 PURPOSE: The goal of this study was to compare the diffusion tensor imaging (DTI) metrics from an end-stage canine Krabbe brain evaluated by MR imaging ex vivo to those of a normal dog brain. We hypothesized that the white matter of the canine Krabbe brain ... Full text Link to item Cite

Risk factors for subsequent febrile seizures in the FEBSTAT study.

Journal Article Epilepsia · July 2016 OBJECTIVES: To identify risk and risk factors for developing a subsequent febrile seizure (FS) in children with a first febrile status epilepticus (FSE) compared to a first simple febrile seizure (SFS). To identify home use of rescue medications for subseq ... Full text Link to item Cite

Automated segmentation of the canine corpus callosum for the measurement of diffusion tensor imaging.

Journal Article Neuroradiol J · February 2016 The goal of this study was to apply image registration-based automated segmentation methods to measure diffusion tensor imaging (DTI) metrics within the canine brain. Specifically, we hypothesized that this method could measure DTI metrics within the canin ... Full text Link to item Cite

Imaging of Cerebrovascular Disease in Pregnancy and the Puerperium.

Journal Article AJR Am J Roentgenol · January 2016 OBJECTIVE: The purpose of this article is to review the unique physiologic changes that characterize pregnancy and the puerperium, some that substantially affect the cerebrovascular system. Conditions that can cause neurologic deterioration and share featu ... Full text Link to item Cite

Imaging of Herpesvirus Infections of the CNS.

Journal Article AJR Am J Roentgenol · January 2016 OBJECTIVE: Herpesviridae are a family of DNA viruses remarkable for their ability to both promote acute infection and enter a latent phase with potential of reactivation. Herpes infections are ubiquitous throughout the human life span, regardless of the de ... Full text Link to item Cite

Predicting degree of myelination based on diffusion tensor imagining of canines with mucopolysaccharidosis type I.

Journal Article Neuroradiol J · December 2015 OBJECTIVE: This study examined the effect of mucopolysaccharidosis (MPS) type 1 on diffusion tensor imaging (DTI) metrics in the canine brain. We hypothesized 1) white matter regions in the MPS brain would show decreased fractional anisotropy (FA) and incr ... Full text Link to item Cite

Diffusion tensor imaging and myelin composition analysis reveal abnormal myelination in corpus callosum of canine mucopolysaccharidosis I.

Journal Article Exp Neurol · November 2015 Children with mucopolysaccharidosis I (MPS I) develop hyperintense white matter foci on T2-weighted brain magnetic resonance (MR) imaging that are associated clinically with cognitive impairment. We report here a diffusion tensor imaging (DTI) and tissue e ... Full text Link to item Cite

Posterior structural brain volumes differ in maltreated youth with and without chronic posttraumatic stress disorder.

Journal Article Dev Psychopathol · November 2015 Magnetic resonance imaging studies of maltreated children with posttraumatic stress disorder (PTSD) suggest that maltreatment-related PTSD is associated with adverse brain development. Maltreated youth resilient to chronic PTSD were not previously investig ... Full text Link to item Cite

An integrated widefield imaging and spectroscopy system for contrast-enhanced, image-guided resection of tumors.

Journal Article IEEE Trans Biomed Eng · May 2015 UNLABELLED: Tumor recurrence following surgery is a common and unresolved medical problem of great importance since surgery is the most widely used treatment for solid-mass tumors worldwide. A contributing factor to tumor recurrence is the presence of resi ... Full text Link to item Cite

Magnetic resonance perfusion for differentiating low grade from high grade gliomas at first presentation

Journal Article Cochrane Database of Systematic Reviews · March 10, 2015 This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the diagnostic test accuracy of magnetic resonance (MR) perfusion imaging in differentiating primary grade II gliomas from higher grade gliomas at first ... Full text Cite

Traumatic brain injury imaging research roadmap.

Journal Article AJNR Am J Neuroradiol · March 2015 The past decade has seen impressive advances in the types of neuroimaging information that can be acquired in patients with traumatic brain injury. However, despite this increase in information, understanding of the contribution of this information to prog ... Full text Link to item Cite

Indocyanine green-loaded nanoparticles for image-guided tumor surgery.

Journal Article Bioconjug Chem · February 18, 2015 Detecting positive tumor margins and local malignant masses during surgery is critical for long-term patient survival. The use of image-guided surgery for tumor removal, particularly with near-infrared fluorescent imaging, is a potential method to facilita ... Full text Link to item Cite

Principles of T2 *-weighted dynamic susceptibility contrast MRI technique in brain tumor imaging.

Journal Article J Magn Reson Imaging · February 2015 Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is used to track the first pass of an exogenous, paramagnetic, nondiffusible contrast agent through brain tissue, and has emerged as a powerful tool in the characterization of brain tumor ... Full text Link to item Cite

Spontaneous brain parenchymal hemorrhage: an approach to imaging for the emergency room radiologist.

Journal Article Emerg Radiol · February 2015 Spontaneous intracranial hemorrhage is a neurological emergency commonly encountered by the emergency radiologist. This article reviews the approach to spontaneous brain parenchymal hemorrhage, including common causes and the role of various neuroimaging m ... Full text Link to item Cite

Correlation of diffusion tensor imaging parameters in the canine brain.

Journal Article Neuroradiol J · February 2015 The goal of this study was to determine the degree to which ex vivo diffusion tensor imaging (DTI) parameters correlate to one another in white matter regions on very high resolution MR scans. Specifically, we hypothesized that radial diffusivity (RD) and ... Full text Link to item Cite

The superior longitudinal fasciculus in typically developing children and adolescents: diffusion tensor imaging and neuropsychological correlates.

Journal Article J Child Neurol · January 2015 The relationship between superior longitudinal fasciculus microstructural integrity and neuropsychological functions were examined in 49 healthy children (range: 5-17 years) using diffusion tensor imaging. Seven major cognitive domains (intelligence, fine- ... Full text Link to item Cite

Umbilical cord blood transplantation to treat Pelizaeus-Merzbacher Disease in 2 young boys.

Journal Article Pediatrics · November 2014 Pelizaeus-Merzbacher Disease (PMD) is a rare X-linked recessive leukodystrophy caused by mutations in the proteolipid protein 1 gene on the Xq22 chromosome. PMD is a dysmyelinating disorder characterized by variable clinical presentation and course. Sympto ... Full text Open Access Link to item Cite

A multiobserver study of the effects of including point-of-care patient photographs with portable radiography: a means to detect wrong-patient errors.

Journal Article Acad Radiol · August 2014 RATIONALE AND OBJECTIVES: To evaluate whether the presence of facial photographs obtained at the point-of-care of portable radiography leads to increased detection of wrong-patient errors. MATERIALS AND METHODS: In this institutional review board-approved ... Full text Link to item Cite

Use of apparent diffusion coefficient values for diagnosis of pediatric posterior fossa tumors.

Journal Article Neuroradiol J · April 2014 We prospectively compared the ability of neuroradiologists to diagnose medulloblastoma with novice raters using only apparent diffusion coefficient (ADC) values measured on ADC maps. One hundred and three pediatric patients with pre-operative magnetic reso ... Full text Link to item Cite

Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study.

Journal Article Ann Neurol · February 2014 OBJECTIVE: Whether febrile status epilepticus (FSE) produces hippocampal sclerosis (HS) and temporal lobe epilepsy (TLE) has long been debated. Our objective is to determine whether FSE produces acute hippocampal injury that evolves to HS. METHODS: FEBSTAT ... Full text Link to item Cite

Evaluation of apparent diffusion coefficient thresholds for diagnosis of medulloblastoma using diffusion-weighted imaging.

Journal Article Neuroradiol J · February 2014 We assess a diffusion-weighted imaging (DWI) analysis technique as a potential basis for computer-aided diagnosis (CAD) of pediatric posterior fossa tumors. A retrospective medical record search identified 103 children (mean age: 87 months) with posterior ... Full text Link to item Cite

Segmentation of the canine corpus callosum using diffusion-tensor imaging tractography.

Journal Article AJR Am J Roentgenol · January 2014 OBJECTIVE: We set out to determine functional white matter (WM) connections passing through the canine corpus callosum; these WM connections would be useful for subsequent studies of canine brains that serve as models for human WM pathway disease. Based on ... Full text Link to item Cite

Tumor cells upregulate normoxic HIF-1α in response to doxorubicin.

Journal Article Cancer Res · October 15, 2013 Hypoxia-inducible factor 1 (HIF-1) is a master transcription factor that controls cellular homeostasis. Although its activation benefits normal tissue, HIF-1 activation in tumors is a major risk factor for angiogenesis, therapeutic resistance, and poor pro ... Full text Link to item Cite

Diffusion tensor imaging of neural tissue organization: correlations between radiologic and histologic parameters.

Journal Article Neuroradiol J · October 2013 This study examined the relationship between histological variables and diffusion tensor imaging (DTI) values in a normal canine brain. We hypothesized that radial diffusivity (RD) would correlate with myelin density and fractional anisotropy (FA) would co ... Full text Link to item Cite

Integrating patient digital photographs with medical imaging examinations.

Journal Article J Digit Imaging · October 2013 We introduce the concept, benefits, and general architecture for acquiring, storing, and displaying digital photographs along with medical imaging examinations. We also discuss a specific implementation built around an Android-based system for simultaneous ... Full text Link to item Cite

Positive deviance.

Journal Article Am J Nurs · October 2013 Full text Link to item Cite

Perfusion MRI: the five most frequently asked clinical questions.

Journal Article AJR Am J Roentgenol · September 2013 OBJECTIVE: This article addresses questions that radiologists frequently ask when planning, performing, processing, and interpreting MRI perfusion studies in CNS imaging. CONCLUSION: Perfusion MRI is a promising tool in assessing stroke, brain tumors, and ... Full text Link to item Cite

Influence of analysis technique on measurement of diffusion tensor imaging parameters.

Journal Article AJR Am J Roentgenol · May 2013 OBJECTIVE: We compared results from various methods of analysis of diffusion tensor imaging (DTI) data from a single dataset consisting of 10 healthy adolescents. SUBJECTS AND METHODS: All subjects were imaged on a single 3-T MRI system (single-shot echo-p ... Full text Link to item Cite

Neurodevelopmental outcomes of umbilical cord blood transplantation in metachromatic leukodystrophy.

Journal Article Biol Blood Marrow Transplant · April 2013 Metachromatic leukodystrophy (MLD) is an inherited demyelinating disease that causes progressive neurologic deterioration, leading to severe motor disability, developmental regression, seizures, blindness, deafness, and death. The disease presents as a lat ... Full text Open Access Link to item Cite

Increasing rate of detection of wrong-patient radiographs: use of photographs obtained at time of radiography.

Journal Article AJR Am J Roentgenol · April 2013 OBJECTIVE: The objective of our study was to evaluate whether facial and chest photographs obtained simultaneously with radiographs increase radiologists' detection rate of labeling errors. MATERIALS AND METHODS: We obtained simultaneous portable radiograp ... Full text Link to item Cite

Features of brain MRI in dogs with treated and untreated mucopolysaccharidosis type I.

Journal Article Comp Med · April 2013 The mucopolysaccharidosis type I (MPS I) dog model has been important in the development of therapies for human patients. We treated dogs with enzyme replacement therapy (ERT) by various approaches. Dogs assessed included untreated MPS I dogs, heterozygous ... Link to item Cite

Childhood cerebral X-linked adrenoleukodystrophy: diffusion tensor imaging measurements for prediction of clinical outcome after hematopoietic stem cell transplantation.

Journal Article AJNR Am J Neuroradiol · March 2013 BACKGROUND AND PURPOSE: DTI in cerebral X-linked adrenoleukodystrophy may demonstrate abnormalities in both affected and nonaffected WM; these values have not been studied serially after hematopoietic stem cell transplantation. The purpose of this study wa ... Full text Link to item Cite

Integrating patient digital photographs with medical imaging examinations

Journal Article Journal of Digital Imaging · 2013 We introduce the concept, benefits, and general architecture for acquiring, storing, and displaying digital photographs along with medical imaging examinations. We also discuss a specific implementation built around an Android-based system for simultaneous ... Full text Cite

Perfusion MRI: the five most frequently asked technical questions.

Journal Article AJR Am J Roentgenol · January 2013 OBJECTIVE: This and its companion article address the 10 most frequently asked questions that radiologists face when planning, performing, processing, and interpreting different MR perfusion studies in CNS imaging. CONCLUSION: Perfusion MRI is a promising ... Full text Link to item Cite

Brain trauma, PET scans and forensic complexity.

Journal Article Behav Sci Law · 2013 Positron Emission Tomography (PET) is a medical imaging technique that can be used to show brain function. Courts have admitted PET scan evidence in cases involving brain damage, injury, toxic exposure, or illness ("brain trauma") and to support claims of ... Full text Link to item Cite

An exploratory study of brain function and structure in mucopolysaccharidosis type I: long term observations following hematopoietic cell transplantation (HCT).

Journal Article Mol Genet Metab · September 2012 AIM: Although hematopoietic cell transplantation (HCT) arrests the cognitive decline in mucopolysaccharidosis type IH (Hurler syndrome, MPS IH), these children continue to have neuropsychological deficits as they age. Both compromised attention and effects ... Full text Link to item Cite

The alphabet soup of perfusion CT and MR imaging: terminology revisited and clarified in five questions.

Journal Article Neuroradiology · September 2012 The five questions answered in this article revolve around the different parameters resulting from perfusion imaging processing, and this clarifies the frequently confusing terminology used to describe these parameters. More specifically, the article discu ... Full text Link to item Cite

Cerebrovascular accident (stroke) in captive, group-housed, female chimpanzees.

Journal Article Comp Med · August 2012 Over a 5-y period, 3 chimpanzees at our institution experienced cerebrovascular accidents (strokes). In light of the increasing population of aged captive chimpanzees and lack of literature documenting the prevalence and effectiveness of various treatments ... Link to item Cite

Assessment of intra-observer variability in measurement of high-grade brain tumors.

Journal Article J Neurooncol · July 2012 A 25% increase in bidimensional products (BPs) of tumor diameter has been used as a criterion for brain tumor progression. We studied intra-observer variability in measurements of BPs. Ten patients with contrast-enhancing glioblastoma multiforme underwent ... Full text Link to item Cite

Analysis of corpus callosum diffusion tensor imaging parameters in infants.

Journal Article Neuroradiol J · July 2012 Radial diffusivity is a diffusion tensor imaging (DTI) metric that has received increased attention in recent studies as a parameter that may better reflect myelination than the more commonly-used fractional anisotropy (FA). This study compared rates of ra ... Full text Link to item Cite

Progression of corpus callosum diffusion-tensor imaging values during a period of signal changes consistent with myelination.

Journal Article AJR Am J Roentgenol · June 2012 OBJECTIVE: Changes in signal intensity on T1- and T2-weighted MR images consistent with myelination in the corpus callosum occur during months 3-9 of postnatal life and occur earlier in the splenium than in the genu. We hypothesized that the rate of change ... Full text Link to item Cite

Neuroradiology: Case 19

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Duke radiology case review: Imaging, differential diagnosis, and discussion: 2nd edition

Book · January 19, 2012 Residents, fellows and practicing radiologists who are preparing for certification exams (the current ABR Part II oral, the future ABR Core and Certifying, CAQ and MOC) will find the new edition of this case-based review book an indispensable tool for succ ... Cite

Neuroradiology

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Use of atorvastatin in systemic lupus erythematosus in children and adolescents.

Journal Article Arthritis Rheum · January 2012 OBJECTIVE: Statins reduce atherosclerosis and cardiovascular morbidity in the general population, but their efficacy and safety in children and adolescents with systemic lupus erythematosus (SLE) are unknown. This study was undertaken to determine the 3-ye ... Full text Link to item Cite

Cartesian positioning system for localization of blast and ballistic fragments: a phantom-based pilot study.

Journal Article Mil Med · November 2011 Our purpose was to demonstrate the consistency of radiologists' three-dimensional measurements of simulated blast fragment locations in vitro in an effort to objectively localize retained fragments and wound paths. We designed a phantom consisting of 10 na ... Full text Link to item Cite

Understanding errors in diagnostic radiology: proposal of a classification scheme and application to emergency radiology.

Journal Article Emerg Radiol · October 2011 Errors in image interpretation are a common problem in diagnostic radiology. Although many published articles provide trainees with the means to correctly interpret imaging studies, they do not provide a framework for understanding why and how errors occur ... Full text Link to item Cite

Diffusion-tensor imaging assessment of white matter maturation in childhood and adolescence.

Journal Article AJR Am J Roentgenol · September 2011 OBJECTIVE: The purpose of this study was to test a first hypothesis that fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values continue to change in late childhood and adolescence and a second hypothesis that less mature white matter ( ... Full text Link to item Cite

Blast and ballistic trajectories in combat casualties: a preliminary analysis using a cartesian positioning system with MDCT.

Journal Article AJR Am J Roentgenol · August 2011 OBJECTIVE: The purpose of this study is to determine the agreement with which radiologists identify wound paths in vivo on MDCT and calculate missile trajectories on the basis of Cartesian coordinates using a Cartesian positioning system (CPS). MATERIALS A ... Full text Link to item Cite

Structural connectivity of the frontal lobe in children with drug-resistant partial epilepsy.

Journal Article Epilepsy Behav · May 2011 The superior longitudinal fasciculus (SLF) II and cingulum are two white matter tracts important for attention and other frontal lobe functions. These functions are often disturbed in children with drug-resistant (DR) partial epilepsy, even when no abnorma ... Full text Link to item Cite

CT-based ballistic wound path identification and trajectory analysis in anatomic ballistic phantoms.

Journal Article Radiology · March 2011 PURPOSE: To evaluate the accuracy of computed tomography (CT)-based ballistic wound path identification in phantoms by determining the agreement between actual shooting angles and both trajectory angles measured with a picture archiving and communication s ... Full text Link to item Cite

Research challenges in central nervous system manifestations of inborn errors of metabolism.

Journal Article Mol Genet Metab · March 2011 The Research Challenges in CNS Manifestations of Inborn Errors of Metabolism workshop was designed to address challenges in translating potential therapies for these rare disorders, and to highlight novel therapeutic strategies and innovative approaches to ... Full text Link to item Cite

Diffusion tensor imaging for evaluation of the childhood brain and pediatric white matter disorders.

Journal Article Neuroimaging Clin N Am · February 2011 Magnetic resonance (MR) imaging has been used by investigators and clinicians to assess the development of the brain in childhood to understand both patterns of normal growth and patterns by which a maturing brain may deviate from normal. Advanced MR techn ... Full text Link to item Cite

Causes of misinterpretation of cross-sectional imaging studies for dissection of the craniocervical arteries.

Journal Article AJR Am J Roentgenol · January 2011 OBJECTIVE: This review presents some of the more common causes of false-positive and false-negative interpretations of cross-sectional imaging studies showing, or designed to show, dissection of the carotid or vertebral arteries. CONCLUSION: Dissection of ... Full text Link to item Cite

Dural sinus thrombosis: sources of error in image interpretation.

Journal Article AJR Am J Roentgenol · January 2011 OBJECTIVE: The purpose of this article is to bring some of the potential causes of false-positive and false-negative interpretations of dural sinus thrombosis (DST) on cross-section imaging studies to the attention of radiologists. CONCLUSION: The prompt d ... Full text Link to item Cite

Current imaging assessment and treatment of intracranial aneurysms.

Journal Article AJR Am J Roentgenol · January 2011 OBJECTIVE: This article reviews current neuroimaging techniques used for screening, diagnosis, and follow-up of patients with intracranial aneurysms as well as neuroendovascular therapeutic options available to patients. CONCLUSION: The diagnosis and manag ... Full text Link to item Cite

Responses to the 10 most frequently asked questions about perfusion CT.

Journal Article AJR Am J Roentgenol · January 2011 OBJECTIVE: The objective of this article is to address the 10 most frequently asked questions radiologists face when planning, performing, processing, and interpreting a perfusion CT study in a patient with clinical suspicion of acute ischemic stroke. CONC ... Full text Link to item Cite

Revising a manuscript: ten principles to guide success for publication.

Journal Article AJR Am J Roentgenol · December 2010 OBJECTIVE: The process of revising a manuscript and successfully responding to the comments of reviewers and the Editor can be difficult. This article provides some practical steps to guide authors in this task and attain publication of their manuscript. C ... Full text Link to item Cite

Correlation of apparent diffusion coefficient and fractional anisotropy values in the developing infant brain.

Journal Article AJR Am J Roentgenol · December 2010 Featured Publication OBJECTIVE: The purpose of our study was to correlate decrease in apparent diffusion coefficient (ADC) and increase in fractional anisotropy (FA) in various white matter (WM) regions using diffusion tenor imaging (DTI) within the first year of life. MATERIA ... Full text Link to item Cite

Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration.

Journal Article Anal Chem · November 1, 2010 Featured Publication Surgery is one of the most effective and widely used procedures in treating human cancers, but a major problem is that the surgeon often fails to remove the entire tumor, leaving behind tumor-positive margins, metastatic lymph nodes, and/or satellite tumor ... Full text Open Access Link to item Cite

Imaging findings of structural causes of epilepsy in children: a guide for the radiologist in the emergency room.

Journal Article Emerg Radiol · November 2010 Evaluation of the child with epilepsy is a relatively common indication for imaging in the emergency room setting. This room outlines some of the more important imaging features of causes of epilepsy in children. ... Full text Link to item Cite

Imaging evaluation of the patient with worst headache of life--it's not all subarachnoid hemorrhage.

Journal Article Emerg Radiol · September 2010 The radiologist working in the emergency radiology setting is often faced with evaluating imaging findings of the patient whose chief complaint is that of the worst headache of life. The diagnosis of subarachnoid hemorrhage (SAH) is usually the initial con ... Full text Link to item Cite

Use of decrease in apparent diffusion coefficient values to predict infarct age.

Journal Article Emerg Radiol · September 2010 The purpose of the study was to determine the ability to predict infarct age based on decrease in apparent diffusion coefficient (ADC) values. We retrospectively identified 94 individuals (age range 16 years to 91 years; mean 63.7 + 14.1 years) who underwe ... Full text Link to item Cite

PET/CT today and tomorrow in veterinary cancer diagnosis and monitoring: fundamentals, early results and future perspectives.

Journal Article Vet Comp Oncol · September 2010 Functional imaging using positron emission tomography (PET) plays an important role in the diagnosis, staging, image-guided treatment planning and monitoring of malignant diseases. PET imaging complements conventional anatomical imaging such as computed to ... Full text Link to item Cite

Frequency of various brain parenchymal findings of early cerebral ischemia on unenhanced CT scans.

Journal Article Emerg Radiol · September 2010 The purpose of the study was to determine the frequency of various unenhanced computed tomography (CT) findings of early cerebral ischemia within brain parenchyma, which could be useful to the radiologist who is interpreting CT studies by indicating the CT ... Full text Link to item Cite

Applications of nanotechnology to imaging and therapy of brain tumors.

Journal Article Neuroimaging Clin N Am · August 2010 Featured Publication In the past decade, numerous advances in the understanding of brain tumor physiology, tumor imaging, and tumor therapy have been attained. In some cases, these advances have resulted from refinements of pre-existing technologies (eg, improvements of contra ... Full text Link to item Cite

Proposal of a method for deciding whether an AJR manuscript merits publication: The 25% rule.

Journal Article AJR Am J Roentgenol · August 2010 OBJECTIVE: The purpose of this article is to propose a rule for determining which recommendation American Journal of Roentgenology (AJR) reviewers should provide when performing a review of a manuscript. CONCLUSION: The rule described here should allow rev ... Full text Link to item Cite

Imaging of traumatic brain injury: a review of the recent medical literature.

Journal Article AJR Am J Roentgenol · January 2010 OBJECTIVE: This article provides a summary of some of the important articles published during the period 2005-2009 on the topic of imaging findings in head trauma. The intent is to provide the latest information regarding the diagnosis of important abnorma ... Full text Link to item Cite

Clinical and imaging findings suggesting human herpesvirus 6 encephalitis.

Journal Article Pediatr Neurol · January 2010 We sought to distinguish patients testing positive for human herpesvirus 6 from those testing negative, based on clinical features and magnetic resonance images. Sixteen immunosuppresed patients were tested by polymerase chain reaction for human herpes vir ... Full text Link to item Cite

Sixty-four-section multidetector CT angiography of carotid arteries: a systematic analysis of image quality and artifacts.

Journal Article AJNR Am J Neuroradiol · January 2010 BACKGROUND AND PURPOSE: Sixty-four-section CT scanners have recently been introduced for vascular imaging. Before such scanners reach widespread use, scanning protocol should be optimized and image quality assessed. The goals of this study were to systemat ... Full text Link to item Cite

Bidimensional measurements in brain tumors: assessment of interobserver variability.

Journal Article AJR Am J Roentgenol · December 2009 Featured Publication OBJECTIVE: Bidimensional tumor measurements indicating a greater than 25% increase in tumor size are generally accepted as indicating tumor progression. We hypothesized that use of digital images and a homogeneous reader population would have lower interob ... Full text Link to item Cite

CT evaluation of subarachnoid hemorrhage: a practical review for the radiologist interpreting emergency room studies.

Journal Article Emerg Radiol · November 2009 Radiologists working in an emergency radiology setting frequently interpret computed tomography (CT) studies of patients with suspected subarachnoid hemorrhage (SAH). This article reviews the sensitivity of CT for detection of SAH, some major patterns of S ... Full text Link to item Cite

Comparison of test performance characteristics of MRI, MR angiography, and CT angiography in the diagnosis of carotid and vertebral artery dissection: a review of the medical literature.

Journal Article AJR Am J Roentgenol · October 2009 OBJECTIVE: Initial assessment of patients with suspected dissection of the carotid or vertebral arteries typically is made by MRI, alone or in combination with MR angiography (MRA) or CT angiography (CTA). We reviewed the medical literature to determine, b ... Full text Link to item Cite

Uses of nanoparticles for central nervous system imaging and therapy.

Journal Article AJNR Am J Neuroradiol · August 2009 Featured Publication Applications of nanotechnology to medicine are leading to novel means of imaging living systems and of delivering therapy. Much nanotechnology research is focused on methods for imaging central nervous system functions and disease states. In this review, t ... Full text Link to item Cite

MRI and MRA for evaluation of dissection of craniocerebral arteries: lessons from the medical literature.

Journal Article Emerg Radiol · May 2009 MR imaging and MR angiography have become first-line imaging techniques in assessment of the patient with suspected dissection of the carotid and vertebral arteries. This review describes the advantages of these two techniques for diagnosis and describes d ... Full text Link to item Cite

Newborn screening for Krabbe disease: the New York State model.

Journal Article Pediatr Neurol · April 2009 Krabbe disease is a rare inherited neurologic disorder affecting the central and peripheral nervous systems. The disease has four phenotypes: early infantile, later onset, adolescent, and adult. The only known treatment is hematopoietic stem cell transplan ... Full text Link to item Cite

Molecular imaging and quantitative measurement of epidermal growth factor receptor expression in live cancer cells using immunolabeled gold nanoparticles.

Journal Article AJR Am J Roentgenol · April 2009 Featured Publication OBJECTIVE: The goal of this study was to assess whether immunolabeled nanoparticle biomarkers are comparable to fluorescent marker imaging in measuring epidermal growth factor receptor (EGFR) expression. MATERIALS AND METHODS: EGFR expression was quantifie ... Full text Link to item Cite

Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism.

Journal Article J Neurodev Disord · March 2009 To examine brain volumes in substructures associated with the behavioral features of children with FXS compared to children with idiopathic autism and controls. A cross-sectional study of brain substructures was conducted at the first time-point as part of ... Full text Link to item Cite

Cerebral white matter integrity mediates adult age differences in cognitive performance.

Journal Article J Cogn Neurosci · February 2009 Featured Publication Previous research has established that age-related decline occurs in measures of cerebral white matter integrity, but the role of this decline in age-related cognitive changes is not clear. To conclude that white matter integrity has a mediating (causal) c ... Full text Link to item Cite

Advances in pediatric neuroradiology: highlights of the recent medical literature.

Journal Article AJR Am J Roentgenol · January 2009 OBJECTIVE: This review is an attempt to bring some of the best articles in the recent pediatric neuroradiology literature to the attention of the AJR readership. CONCLUSION: Many advanced imaging capabilities are being brought to bear to noninvasively moni ... Full text Link to item Cite

Imaging findings in neonatal hypoxia: a practical review.

Journal Article AJR Am J Roentgenol · January 2009 OBJECTIVE: The findings of hypoxia in the term neonate are unique; neonatal brain imaging findings differ from those of older children. Evaluation of neonatal brain images for signs of hypoxic injury requires attention to a specific set of signs. CONCLUSIO ... Full text Link to item Cite

Correlation of neurodevelopmental features and MRI findings in infantile Krabbe's disease.

Journal Article AJR Am J Roentgenol · January 2009 OBJECTIVE: The purpose of our study was to compare MRI findings with neurobehavioral development in infants with Krabbe's disease. MATERIALS AND METHODS: Nine infants with Krabbe's disease underwent a total of 19 MR studies during the first year of life as ... Full text Link to item Cite

A neuroradiology self-assessment module for use in emergency radiology.

Journal Article Emerg Radiol · January 2009 Radiologists interpreting imaging studies of the central nervous system are well acquainted with the findings of various common neuroradiological disorders. This self-assessment module is intended to test the knowledge base of radiologists working in the e ... Full text Link to item Cite

Extrahippocampal involvement in human herpesvirus 6 encephalitis depicted at MR imaging.

Journal Article Radiology · December 2008 PURPOSE: To test the hypothesis that patterns of signal intensity abnormality in human herpesvirus 6 (HHV6)-positive patients would allow distinction from patients who did not test positive for HHV6 encephalitis. MATERIALS AND METHODS: This retrospective s ... Full text Link to item Cite

In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy.

Journal Article AJR Am J Roentgenol · December 2008 Featured Publication OBJECTIVE: Bioluminescence imaging is a powerful technique that has shown that hypoxia-inducible factor 1 (HIF-1), a transcription factor that protects tumor cells from hypoxia, is up-regulated in tumors after radiation therapy. We tested the hypothesis th ... Full text Link to item Cite

Optimization of perfusion imaging for acute cerebral ischemia: review of recent clinical trials and recommendations for future studies.

Journal Article AJR Am J Roentgenol · October 2008 OBJECTIVE: The use of thrombolytic agents and other forms of reperfusion therapy has provided a means to reverse ischemia and minimize the size of infarctions. The purpose of this review is to examine various clinical trials of reperfusion agents and addre ... Full text Link to item Cite

Systematic review of CT and MR perfusion imaging for assessment of acute cerebrovascular disease.

Journal Article AJNR Am J Neuroradiol · September 2008 BACKGROUND AND PURPOSE: Perfusion imaging sequences are an important part of imaging studies designed to provide information to guide therapy for treatment of cerebrovascular disease. The purpose of this study was to perform a meta-analysis of the medical ... Full text Link to item Cite

Age-related slowing of memory retrieval: contributions of perceptual speed and cerebral white matter integrity.

Journal Article Neurobiol Aging · July 2008 Previous research suggests that, in reaction time (RT) measures of episodic memory retrieval, the unique effects of adult age are relatively small compared to the effects aging shares with more elementary abilities such as perceptual speed. Little is known ... Full text Link to item Cite

Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.

Journal Article Neuro Oncol · June 2008 Featured Publication The purpose of this study is to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and intracerebral distribution of a recombinant toxin (TP-38) targeting the epidermal growth factor receptor in patients with recurrent malignant brai ... Full text Link to item Cite

Acute stroke imaging research roadmap.

Journal Article AJNR Am J Neuroradiol · May 2008 The recent "Advanced Neuroimaging for Acute Stroke Treatment" meeting on September 7 and 8, 2007 in Washington DC, brought together stroke neurologists, neuroradiologists, emergency physicians, neuroimaging research scientists, members of the National Inst ... Full text Link to item Cite

Hippocampal MRI signal hyperintensity after febrile status epilepticus is predictive of subsequent mesial temporal sclerosis.

Journal Article AJR Am J Roentgenol · April 2008 OBJECTIVE: The objective of our study was to test the hypothesis that the finding of hyperintense hippocampal signal intensity on T2-weighted MR images soon after febrile status epilepticus is associated with subsequent hippocampal volume loss and persiste ... Full text Link to item Cite

Nephrogenic systemic fibrosis: possible association with a predisposing infection.

Journal Article AJR Am J Roentgenol · April 2008 OBJECTIVE: Infection at time of MR contrast administration has been reported to predispose patients with renal failure to development of nephrogenic systemic fibrosis (NSF). We assessed the frequency of infection at the time of MR contrast administration i ... Full text Link to item Cite

Aging, gender, and the elderly adult brain: an examination of analytical strategies.

Journal Article Neurobiol Aging · February 2008 We sought to examine the relations between age, gender and brain volumes in an elderly population; we also sought to examine ways of measuring these relations. Three sets of analyses were used: correlational analyses, in which correlations between independ ... Full text Link to item Cite

Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms.

Journal Article Psychol Med · December 2007 BACKGROUND: Orbitofrontal cortex (OFC) volumetric differences have been reported in depression, but in relatively small samples. Factors associated with these differences are not well described. We examined OFC volumes in a large sample of elderly depresse ... Full text Link to item Cite

Aneurysm clip.

Journal Article J Neurosurg · December 2007 Full text Link to item Cite

Diffusion tensor imaging assessment of brain white matter maturation during the first postnatal year.

Journal Article AJR Am J Roentgenol · August 2007 Featured Publication OBJECTIVE: The purpose of this study was to use diffusion-weighted and diffusion tensor imaging to investigate the status of cerebral white matter (WM) at term gestation and the rate of WM maturation throughout the first year of life in healthy infants. MA ... Full text Link to item Cite

Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions.

Journal Article Neuro Oncol · July 2007 Convection-enhanced delivery (CED) is a novel drug delivery technique that uses positive infusion pressure to deliver therapeutic agents directly into the interstitial spaces of the brain. Despite the promise of CED, clinical trials have demonstrated that ... Full text Link to item Cite

Outcomes of unrelated umbilical cord blood transplantation for X-linked adrenoleukodystrophy.

Journal Article Biol Blood Marrow Transplant · June 2007 Featured Publication Adrenoleukodystrophy (ALD) is an X-linked disorder caused by a defect in the metabolism of long chain fatty acids leading to demyelination, neurodegeneration, and death. The disease typically presents in young boys and adolescent boys. Allogeneic bone marr ... Full text Link to item Cite

Widespread effects of hyperintense lesions on cerebral white matter structure.

Journal Article AJR Am J Roentgenol · June 2007 OBJECTIVE: Hyperintense lesions are a common finding on neuroimaging and are associated not only with aging, medical illness, and some invasive medical procedures, but also with neurologic and psychiatric morbidity. We hypothesized that hyperintense lesion ... Full text Link to item Cite

Ten principles to improve the likelihood of publication of a scientific manuscript.

Journal Article AJR Am J Roentgenol · May 2007 OBJECTIVE: The objective of this article is to discuss the reasons that manuscripts fail to be published and to establish some principles for increasing the likelihood of publication. CONCLUSION: Many good manuscripts fail to be published because they viol ... Full text Link to item Cite

Phase II study of imatinib mesylate and hydroxyurea for recurrent grade III malignant gliomas.

Journal Article J Neurooncol · May 2007 PURPOSE: Recent reports demonstrate the activity of imatinib mesylate, an ATP-mimetic, tyrosine kinase inhibitor, plus hydroxyurea, a ribonucleotide reductase inhibitor, in patients with recurrent glioblastoma multiforme. We performed the current phase 2 s ... Full text Link to item Cite

Superparamagnetic iron oxide labeling and transplantation of adipose-derived stem cells in middle cerebral artery occlusion-injured mice.

Journal Article AJR Am J Roentgenol · April 2007 OBJECTIVE: Adipose-derived stem cells are an alternative stem cell source for CNS therapies. The goals of the current study were to label adipose-derived stem cells with superparamagnetic iron oxide (SPIO) particles, to use MRI to guide the transplantation ... Full text Link to item Cite

Anatomic variant of the posterior cerebral artery.

Journal Article AJR Am J Roentgenol · April 2007 Full text Link to item Cite

CT and MR imaging of acute cranial trauma.

Journal Article Emerg Radiol · April 2007 A wide variety of imaging findings can be seen in the setting of acute head trauma. The purpose of this manuscript is to review the major computed tomography and magnetic resonance imaging findings of various types of traumatic head injuries with the inten ... Full text Link to item Cite

Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin.

Journal Article AJR Am J Roentgenol · March 2007 OBJECTIVE: Convection-enhanced delivery is a promising approach to intracerebral drug delivery in which a fluid pressure gradient is used to infuse therapeutic macromolecules through an indwelling catheter into the interstitial spaces of the brain. Our pur ... Full text Link to item Cite

Adult age differences in the functional neuroanatomy of visual attention: a combined fMRI and DTI study.

Journal Article Neurobiol Aging · March 2007 Featured Publication We combined measures from event-related functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), and cognitive performance (visual search response time) to test the hypotheses that differences between younger and older adults in top-do ... Full text Link to item Cite

MR imaging of spinal trauma.

Journal Article Emerg Radiol · March 2007 Magnetic resonance (MR) imaging plays an increasingly important role in evaluation of the patient who has sustained spinal trauma. This review discusses the role of MR imaging relative to plain radiographs and computed tomography in the evaluation of the p ... Full text Link to item Cite

Role of aerobic fitness and aging on cerebral white matter integrity.

Journal Article Ann N Y Acad Sci · February 2007 Neuroimaging research suggests that cerebral white matter (WM) integrity, as reflected in fractional anisotropy (FA) via diffusion tensor imaging (DTI), is decreased in older adults, especially in the prefrontal regions of the brain. Behavioral investigati ... Full text Link to item Cite

Imaging of angiogenesis: clinical techniques and novel imaging methods.

Journal Article AJR Am J Roentgenol · January 2007 Featured Publication OBJECTIVE: A wide variety of antiangiogenic agents have been developed for the treatment of neoplasms. Imaging studies play an important role in assessing the effects of these treatments. CONCLUSION: This review article introduces radiologists to features ... Full text Link to item Cite

Imagining imaging: radiology practice in 2050.

Journal Article AJR Am J Roentgenol · December 2006 Full text Link to item Cite

Differences in brain volumes among males and female hormone-therapy users and nonusers.

Journal Article Psychiatry Res · October 30, 2006 Numerous studies have shown gender differences in the brain volumes of elderly adults. Some evidence shows that higher estrogen levels may be neuroprotective, suggesting that hormone therapy (HT) may in part be responsible for these gender differences; how ... Full text Link to item Cite

Correlation of relative permeability and relative cerebral blood volume in high-grade cerebral neoplasms.

Journal Article AJR Am J Roentgenol · October 2006 OBJECTIVE: The purpose of this study was to correlate the degree of contrast enhancement on dynamic contrast-enhanced T1-weighted MRI and the relative cerebral blood volume (rCBV) values on T2*-weighted MRI in patients with high-grade brain neoplasms. SUBJ ... Full text Link to item Cite

Magnetic resonance and diffusion tensor imaging in pediatric white matter diseases.

Journal Article Top Magn Reson Imaging · August 2006 The central nervous system undergoes profound and predictable developmental changes during the first few years of life that provide the structural and functional elements necessary for normal neurological development. The establishment and maturation of wh ... Full text Link to item Cite

Diffusion-weighted and perfusion MR imaging for brain tumor characterization and assessment of treatment response.

Journal Article Radiology · June 2006 Featured Publication Diffusion-weighted magnetic resonance (MR) imaging and perfusion MR imaging are advanced techniques that provide information not available from conventional MR imaging. In particular, these techniques have a number of applications with regard to characteri ... Full text Link to item Cite

A systematic guide to reviewing a manuscript.

Journal Article J Nucl Med Technol · June 2006 OBJECTIVE: In this article, we provide a step-by-step guide to reviewing a manuscript that we hope will improve the quality of reviews for the AJR. CONCLUSION: We have provided a detailed series of guidelines for providing excellent reviews of manuscripts. ... Link to item Cite

Novel human IgG2b/murine chimeric antitenascin monoclonal antibody construct radiolabeled with 131I and administered into the surgically created resection cavity of patients with malignant glioma: phase I trial results.

Journal Article J Nucl Med · June 2006 UNLABELLED: Results from animal experiments have shown that human IgG2/mouse chimeric antitenascin 81C6 (ch81C6) monoclonal antibody exhibited higher tumor accumulation and enhanced stability compared with its murine parent. Our objective was to determine ... Link to item Cite

Response (4)

Journal Article Radiology · May 1, 2006 Cite

Incidence and patterns of neuraxis metastases in children with diffuse pontine glioma.

Journal Article J Neurooncol · April 2006 PURPOSE: We performed a retrospective study of patients with diffuse pontine glioma (DPG) who suffered neuraxis metastasis (NM) and characterized the incidence, clinical features, radiologic findings, and patterns of disease dissemination. METHODS: Magneti ... Full text Link to item Cite

Central nervous system extraosseous Ewing sarcoma: radiologic manifestations of this newly defined pathologic entity.

Journal Article AJNR Am J Neuroradiol · March 2006 Although these entities are histologically similar, recent advances in molecular genetics have allowed the distinction of central nervous system extraosseous Ewing sarcoma (CNS-EES) from central primitive neuroectodermal tumors (c-PNET) including medullobl ... Link to item Cite

Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma.

Journal Article Clin Cancer Res · February 1, 2006 PURPOSE: To determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of gefitinib, a receptor tyrosine kinase inhibitor of the epidermal growth factor receptor, plus sirolimus, an inhibitor of the mammalian target of rapamycin, among pat ... Full text Link to item Cite

A liposomal nanoscale contrast agent for preclinical CT in mice.

Journal Article AJR Am J Roentgenol · February 2006 OBJECTIVE: The goal of this study was to determine if an iodinated, liposomal contrast agent could be used for high-resolution, micro-CT of low-contrast, small-size vessels in a murine model. MATERIALS AND METHODS: A second-generation, liposomal blood pool ... Full text Link to item Cite

Astrocytoma of the spinal cord

Chapter · January 1, 2006 Full text Cite

Anaplastic astrocytoma

Chapter · January 1, 2006 Cite

Astrocytoma of the brainstem

Chapter · January 1, 2006 Full text Cite

Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results.

Journal Article J Clin Oncol · January 1, 2006 PURPOSE: To assess the efficacy and toxicity of intraresection cavity iodine-131-labeled murine antitenascin monoclonal antibody 81C6 (131I-m81C6) among recurrent malignant brain tumor patients. PATIENTS AND METHODS: In this phase II trial, 100 mCi of 131I ... Full text Link to item Cite

Molecular imaging: Facing the future

Journal Article American Journal of Roentgenology · January 1, 2006 Full text Cite

Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme.

Journal Article J Clin Oncol · December 20, 2005 PURPOSE: We performed a phase II study to evaluate the combination of imatinib mesylate, an adenosine triphosphate mimetic, tyrosine kinase inhibitor, plus hydroxyurea, a ribonucleotide reductase inhibitor, in patients with recurrent glioblastoma multiform ... Full text Link to item Cite

Cortical white matter microstructural abnormalities in bipolar disorder.

Journal Article Neuropsychopharmacology · December 2005 This article reports on preliminary findings describing microstructural abnormalities in the white matter of cortical areas thought to be associated with bipolar disorder. In all, 14 patients with bipolar disorder and 21 nonpsychiatrically ill control subj ... Full text Link to item Cite

Quantitative analysis of diffusion tensor imaging data in serial assessment of Krabbe disease.

Journal Article Ann N Y Acad Sci · December 2005 Krabbe disease is a rare autosomal recessive pediatric white matter (WM) disorder that is due to deficiency of a specific enzyme, beta-galactocerebrosidase. This report reviews our experience with use of diffusion tensor imaging (DTI) in serial assessment ... Full text Link to item Cite

Magnetic resonance imaging and head circumference study of brain size in autism: birth through age 2 years.

Journal Article Arch Gen Psychiatry · December 2005 CONTEXT: While the neuroanatomical basis of autism is not yet known, evidence suggests that brain enlargement may be characteristic of this disorder. Inferences about the timing of brain enlargement have recently come from studies of head circumference (HC ... Full text Link to item Cite

Ependymoma

Journal Article · December 1, 2005 Full text Cite

A systematic guide to reviewing a manuscript.

Journal Article AJR Am J Roentgenol · October 2005 OBJECTIVE: In this article, we provide a step-by-step guide to reviewing a manuscript that we hope will improve the quality of reviews for the AJR. CONCLUSION: We have provided a detailed series of guidelines for providing excellent reviews of manuscripts. ... Full text Link to item Cite

Phase I trial of irinotecan plus temozolomide in adults with recurrent malignant glioma.

Journal Article Cancer · October 1, 2005 BACKGROUND: The authors determined the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of irinotecan (CPT-11), a topoisomerase I inhibitor, when administered with temozolomide among patients with recurrent malignant glioma (MG). METHODS: Pati ... Full text Link to item Cite

Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.

Journal Article J Clin Oncol · October 1, 2005 PURPOSE: We conducted a two-phase clinical trial in patients with progressive malignant glioma (MG). The first phase of this trial was designed to determine the dose of O6-BG effective in producing complete depletion of tumor AGT activity for 48 hours. The ... Full text Link to item Cite

The role of blood-brain barrier permeability in brain tumor imaging and therapeutics.

Journal Article AJR Am J Roentgenol · September 2005 Featured Publication OBJECTIVE: Our purpose is to describe methods of assessing leakiness of the blood-brain barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic purposes. CONCLUSION: Knowledge of the workings of the blood-brain barrier is impo ... Full text Link to item Cite

Determination of multiple sclerosis plaque size with diffusion-tensor MR Imaging: comparison study with healthy volunteers.

Journal Article Radiology · August 2005 Featured Publication PURPOSE: To use diffusion-tensor magnetic resonance (MR) imaging to measure involvement of normal-appearing white matter (WM) immediately adjacent to multiple sclerosis (MS) plaques and thus redefine actual plaque size on diffusion-tensor images through co ... Full text Link to item Cite

Krabbe disease treated with hematopoietic stem cell transplantation: serial assessment of anisotropy measurements--initial experience.

Journal Article Radiology · July 2005 Featured Publication PURPOSE: To prospectively compare diffusion-tensor magnetic resonance (MR) imaging anisotropy measurements of white matter (WM) regions in early and late treatment groups of Krabbe disease patients treated with stem cell transplantation. MATERIALS AND METH ... Full text Link to item Cite

Reviewing the reviewers: comparison of review quality and reviewer characteristics at the American Journal of Roentgenology.

Journal Article AJR Am J Roentgenol · June 2005 OBJECTIVE: The purpose of our study was to determine which manuscript reviewer characteristics are most strongly associated with reviewer performance as judged by editors of the American Journal of Roentgenology (AJR). MATERIALS AND METHODS: At the AJR, ma ... Full text Link to item Cite

Dosimetry and radiographic analysis of 131I-labeled anti-tenascin 81C6 murine monoclonal antibody in newly diagnosed patients with malignant gliomas: a phase II study.

Journal Article J Nucl Med · June 2005 UNLABELLED: The objective was to perform dosimetry and evaluate dose-response relationships in newly diagnosed patients with malignant brain tumors treated with direct injections of (131)I-labeled anti-tenascin murine 81C6 monoclonal antibody (mAb) into su ... Link to item Cite

Greater MRI lesion volumes in elderly depressed subjects than in control subjects.

Journal Article Psychiatry Res · May 30, 2005 Featured Publication Hyperintense lesions in both white matter and gray matter on T2-weighted magnetic resonance imaging (MRI) are associated with late-life depression. This large study examined differences in gray and white matter lesion volumes on brain MRI between 253 elder ... Full text Link to item Cite

Transplantation of umbilical-cord blood in babies with infantile Krabbe's disease.

Journal Article N Engl J Med · May 19, 2005 BACKGROUND: Infantile Krabbe's disease produces progressive neurologic deterioration and death in early childhood. We hypothesized that transplantation of umbilical-cord blood from unrelated donors before the development of symptoms would favorably alter t ... Full text Link to item Cite

Association of internal carotid artery injury with carotid canal fractures in patients with head trauma.

Journal Article AJR Am J Roentgenol · May 2005 Featured Publication OBJECTIVE: The purpose of our study was to determine the degree to which carotid canal fracture and other CT findings are associated with internal carotid artery (ICA) injury in patients with head trauma. MATERIALS AND METHODS: Three neuroradiologists retr ... Full text Link to item Cite

Assessment of apparent diffusion coefficient in normal and degenerated intervertebral lumbar disks: initial experience.

Journal Article Radiology · May 2005 PURPOSE: To determine prospectively the diffusibility of water in normal lumbar disks in adults by using the mean apparent diffusion coefficient (ADC) and to determine if a relationship exists between disk ADC and magnetic resonance (MR) findings of disk d ... Full text Link to item Cite

Radiology's role in covering all the bases.

Journal Article AJR Am J Roentgenol · April 2005 Full text Link to item Cite

Assessing patient utilities for varying degrees of low back pain.

Journal Article Acad Radiol · April 2005 RATIONALE AND OBJECTIVES: We sought to quantify patient preferences for mild, moderate, and severe low back pain via time-tradeoff analysis and utility measurement. MATERIALS AND METHODS: Forty-one patients being treated for low back pain in a tertiary car ... Full text Link to item Cite

Biological and social predictors of long-term geriatric depression outcome.

Journal Article Int Psychogeriatr · March 2005 OBJECTIVE: In this study, we examined 204 older depressed individuals for up to 64 months to determine factors related to depression outcome. We hypothesized that both presence of vascular brain lesions seen on baseline magnetic resonance imaging (MRI) sca ... Full text Link to item Cite

Radiological advances: Putting things in perspective

Journal Article American Journal of Roentgenology · January 1, 2005 Full text Cite

Peer review at the American Journal of Roentgenology: how reviewer and manuscript characteristics affected editorial decisions on 196 major papers.

Journal Article AJR Am J Roentgenol · December 2004 OBJECTIVE: The objective of this study was to examine the relative influence of manuscript characteristics and peer-reviewer attributes in the assessment of manuscripts. MATERIALS AND METHODS: Over a 6-month period, all major papers submitted to the Americ ... Full text Link to item Cite

Changes in magnetization transfer MRI correlate with spreading depression-induced astroglial reactivity and increased protein expression in mice.

Journal Article AJR Am J Roentgenol · December 2004 OBJECTIVE: Gliosis refers to a range of glial cell transformations that vary according to specific brain pathologic states. Disease, however, is not a prerequisite for gliosis because glial reactivity may also be seen in regions of increased physiologic ac ... Full text Link to item Cite

Distinction between cerebral abscesses and high-grade neoplasms by dynamic susceptibility contrast perfusion MRI.

Journal Article AJR Am J Roentgenol · November 2004 Featured Publication OBJECTIVE: The purpose of the study was to determine whether dynamic susceptibility contrast perfusion MRI allowed distinction of cerebral abscesses from cystic high-grade brain neoplasms. CONCLUSION: In this small preliminary study, dynamic susceptibility ... Full text Link to item Cite

Peritumoral brain regions in gliomas and meningiomas: investigation with isotropic diffusion-weighted MR imaging and diffusion-tensor MR imaging.

Journal Article Radiology · August 2004 Featured Publication PURPOSE: To retrospectively measure the diffusion-weighted (DW) imaging characteristics of peritumoral hyperintense white matter (WM) and peritumoral normal-appearing WM, as seen on T2-weighted magnetic resonance (MR) images of infiltrative high-grade glio ... Full text Link to item Cite

Redefinition of multiple sclerosis plaque size using diffusion tensor MRI.

Journal Article AJR Am J Roentgenol · August 2004 Featured Publication OBJECTIVE: We used diffusion tensor MRI to redefine the size of multiple sclerosis (MS) plaques on fractional anisotropy (FA) maps. MATERIALS AND METHODS: Thirty-six white matter (WM) plaques were identified in 20 patients with MS. Plaque FA was measured b ... Full text Link to item Cite

Trilateral retinoblastoma: clinical and radiologic progression.

Journal Article AJR Am J Roentgenol · August 2004 OBJECTIVE: The purpose of this study was to assess the clinical and radiologic features of tumor progression in children with trilateral retinoblastoma. MATERIALS AND METHODS: Clinical records of eight children with trilateral retinoblastoma were reviewed ... Full text Link to item Cite

Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter.

Journal Article Am J Psychiatry · July 2004 Featured Publication OBJECTIVE: The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression. METHOD: Seventeen elderly depressed subjects were compared with ... Full text Link to item Cite

Phase 1 trial of irinotecan plus BCNU in patients with progressive or recurrent malignant glioma.

Journal Article Neuro Oncol · April 2004 Irinotecan is a topoisomerase I inhibitor previously shown to be active in the treatment of malignant glioma. We now report the results of a phase 1 trial of irinotecan plus BCNU, or 1,3-bis(2-chloroethyl)-1-nitrosourea, for patients with recurrent or prog ... Full text Link to item Cite

Phase 2 trial of BCNU plus irinotecan in adults with malignant glioma.

Journal Article Neuro Oncol · April 2004 In preclinical studies, BCNU, or 1,3-bis(2-chloroethyl)-1-nitrosourea, plus CPT-11 (irinotecan) exhibits schedule-dependent, synergistic activity against malignant glioma (MG). We previously established the maximum tolerated dose of CPT-11 when administere ... Full text Link to item Cite

Diffusion tensor imaging of adult age differences in cerebral white matter: relation to response time.

Journal Article Neuroimage · March 2004 Diffusion tensor imaging (DTI) measures the displacement of water molecules across tissue components, thus providing information regarding the microstructure of cerebral white matter. Fractional anisotropy (FA), the degree to which diffusion is directional ... Full text Link to item Cite

Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression.

Journal Article Biol Psychiatry · February 15, 2004 BACKGROUND: There is a substantial body of research supporting the vascular depression hypothesis of late-life depression. To update this hypothesis so it incorporates recent research, we propose that the term subcortical ischemic vascular depression may b ... Full text Link to item Cite

Age-related changes in neural activity during visual target detection measured by fMRI.

Journal Article Cereb Cortex · February 2004 We used functional magnetic resonance imaging (fMRI) of a visual target detection (oddball) task to investigate age differences in neural activation for the detection of two types of infrequent events: visually simple items requiring a response shift (targ ... Full text Link to item Cite

Enhancing research: Time for a new game plan?

Journal Article American Journal of Roentgenology · January 1, 2004 Full text Cite

Assessment of the patient with hyperacute stroke: imaging and therapy.

Journal Article Radiology · November 2003 Neuroimaging is an important part of the assessment of patients with hyperacute stroke. As new treatments that may reverse cerebral ischemia have been developed, the role of neuroimaging has changed from simply anatomic depiction of early infarction to ide ... Full text Link to item Cite

White matter hyperintensity progression and late-life depression outcomes.

Journal Article Arch Gen Psychiatry · November 2003 CONTEXT: White matter hyperintensities (WMHs) are bright foci seen in the parenchyma of the brain on T2-weighted cranial magnetic resonance imaging (MRI) scans and are associated with geriatric depression. Because they are associated with age, they should ... Full text Link to item Cite

Correlation of early dynamic CT perfusion imaging with whole-brain MR diffusion and perfusion imaging in acute hemispheric stroke.

Journal Article AJNR Am J Neuroradiol · October 2003 BACKGROUND AND PURPOSE: Compared with MR imaging, dynamic CT perfusion imaging covers only a fraction of the whole brain. An important assumption is that CT perfusion abnormalities correlate with total ischemic volume. The purpose of our study was to measu ... Link to item Cite

Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors.

Journal Article J Neurooncol · October 2003 TP-38 is a recombinant chimeric targeted toxin composed of the EGFR binding ligand TGF-alpha and a genetically engineered form of the Pseudomonas exotoxin, PE-38. After in vitro and in vivo animal studies that showed specific activity and defined the maxim ... Full text Link to item Cite

Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression.

Journal Article Biol Psychiatry · September 1, 2003 Previous studies have shown a reduction of orbital frontal cortex volume and an increase in magnetic resonance imaging signal hyperintensities in geriatric depression. We aimed to assess the relationship between subcortical gray- and deep white-matter lesi ... Full text Link to item Cite

Serial MR imaging of volumes of hyperintense white matter lesions in elderly patients: correlation with vascular risk factors.

Journal Article AJR Am J Roentgenol · August 2003 OBJECTIVE: The purpose of the study was to examine change in volume of hyperintense white matter lesions in a cohort of community-dwelling elderly subjects without neuropsychiatric disease. SUBJECTS AND METHODS. One hundred seventeen volunteers underwent b ... Full text Link to item Cite

Cerebral blood flow, blood volume, and vascular permeability of cerebral glioma assessed with dynamic CT perfusion imaging.

Journal Article Neuroradiology · June 2003 We report dynamic CT perfusion imaging assessment of hemodynamics in a patient with a high-grade cerebral glioma and compare our results to those of previously published studies. ... Full text Link to item Cite

High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas.

Journal Article J Clin Oncol · June 1, 2003 PURPOSE: We evaluated the usefulness of a treatment regimen that included high-dose chemotherapy (HDC) with autologous stem-cell rescue (ASCR) in patients with newly diagnosed pineoblastoma (PBL). PATIENTS AND METHODS: Twelve patients with PBL were initial ... Full text Link to item Cite

Localization of age-associated white matter hyperintensities in late-life depression.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · May 2003 OBJECTIVE: Deep white matter hyperintense lesions are associated with advanced age and late-life depression. The authors examined where age-related cerebral lesions occurred in elderly depressed and healthy control subjects. METHODS: Eighty-seven depressed ... Full text Link to item Cite

Preoperative evaluation of neural tracts by use of three-dimensional anisotropy contrast imaging in a patient with brainstem cavernous angioma: technical case report.

Journal Article Neurosurgery · May 2003 OBJECTIVE AND IMPORTANCE: We describe a case of brainstem cavernous angioma in which the neural tracts were evaluated before surgery by three-dimensional anisotropy contrast (3-DAC) magnetic resonance imaging. CLINICAL PRESENTATION: A 64-year-old man prese ... Link to item Cite

Lexical and sublexical components of age-related changes in neural activation during visual word identification.

Journal Article J Cogn Neurosci · April 1, 2003 Positron emission tomography data (Madden, Langley, et al., 2002) were analyzed to investigate adult age differences in the relation between neural activation and the lexical (word frequency) and sublexical (word length) components of visual word identific ... Full text Link to item Cite

Quantitative assessment of the time course of infarct signal intensity on diffusion-weighted images.

Journal Article AJNR Am J Neuroradiol · April 2003 BACKGROUND AND PURPOSE: Diffusion-weighted (DW) MR imaging is important in evaluating acute stroke, and knowledge of the signal intensity changes associated with acute stroke is valuable. Our purpose was to model the time course of the signal intensity of ... Link to item Cite

Phase II trial of temozolomide in patients with progressive low-grade glioma.

Journal Article J Clin Oncol · February 15, 2003 PURPOSE: Temozolomide (Temodar; Schering-Plough Corp, Kenilworth, NJ) is an imidazole tetrazinone that undergoes chemical conversion to the active methylating agent 5-(3-methyltriazen-1yl)imidazole-4-carboximide under physiologic conditions. Previous studi ... Full text Link to item Cite

Screening for cerebral metastases with FDG PET in patients undergoing whole-body staging of non-central nervous system malignancy.

Journal Article Radiology · January 2003 PURPOSE: To compare fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) with the current standard, magnetic resonance (MR) imaging, to determine the sensitivity and specificity of FDG PET for detection of cerebral metastases and to dete ... Full text Link to item Cite

Perfusion CT with iodinated contrast material.

Journal Article AJR Am J Roentgenol · January 2003 Full text Link to item Cite

Infarct volume on apparent diffusion coefficient maps correlates with length of stay and outcome after middle cerebral artery stroke.

Journal Article Cerebrovasc Dis · 2003 BACKGROUND: Diffusion-weighted MRI (DWI) can depict acute ischemia based on decreased apparent diffusion coefficient (ADC) values. ADC maps, unlike DWI (which have contributions from T2 properties), solely reflect diffusion properties. Recent studies indic ... Full text Link to item Cite

MRI lesion severity and mortality in geriatric depression.

Journal Article Am J Geriatr Psychiatry · 2003 OBJECTIVE: The authors correlated magnetic resonance imaging (MRI) lesion severity and mortality among depressed elderly patients. METHOD: They examined the association of mortality and deep white-matter hyperintensity (DWMH), periventricular hyperintensit ... Full text Link to item Cite

Time course of tetrahydrocannabinol-induced changes in regional cerebral blood flow measured with positron emission tomography.

Journal Article Psychiatry Res · December 30, 2002 While several studies are available on the immediate effects of marijuana and its active ingredient tetrahydrocannabinol (THC) on regional cerebral blood flow (rCBF), we examined the effects of intravenous infusion of THC on rCBF and behavior over a 120-mi ... Full text Link to item Cite

Evaluation of normal age-related changes in anisotropy during infancy and childhood as shown by diffusion tensor imaging.

Journal Article AJR Am J Roentgenol · December 2002 OBJECTIVE: The first purpose of this study was to compare the degree of anisotropy in compact white matter and noncompact white matter in each of three pediatric age groups using diffusion tensor imaging. We hypothesized that anisotropy would be higher in ... Full text Link to item Cite

Advances in brain tumor imaging and therapy

Journal Article Neuroimaging Clinics of North America · November 1, 2002 Full text Cite

Development of a semi-automated method for quantification of MRI gray and white matter lesions in geriatric subjects.

Journal Article Psychiatry Res · August 20, 2002 Brain magnetic resonance imaging (MRI) allows for quantitative assessment of hyperintense foci, which are seen with aging and various diseases. These foci, considered to represent lesions, are important in the study of various psychiatric illnesses, includ ... Full text Link to item Cite

Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype.

Journal Article Am J Med Genet · August 8, 2002 The purpose of the study was to consider MRI hyperintensities as a potential endophenotype for bipolar disorder (BPD) and to investigate Notch3 (CADASIL) as a candidate gene for BPD. MRI scans were performed on 21 members of a family with a high incidence ... Full text Link to item Cite

Adult age differences in visual word identification: functional neuroanatomy by positron emission tomography.

Journal Article Brain Cogn · August 2002 Adult age differences in the neural systems mediating semantic (context-independent) memory were investigated using positron emission tomography (PET). Younger (20-29 years) and older (62-70 years) participants performed lexical decision (word/nonword disc ... Full text Link to item Cite

Evaluation of software for registration of contrast-enhanced brain MR images in patients with glioblastoma multiforme.

Journal Article AJR Am J Roentgenol · July 2002 OBJECTIVE: We evaluated commercially available software that rapidly and automatically registers brain MR images on a clinical workstation, and we studied the accuracy of these registrations. SUBJECTS AND METHODS: Ten patients with a diagnosis of glioblast ... Full text Link to item Cite

Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics.

Journal Article Radiology · July 2002 PURPOSE: To determine if water diffusivity within lymphomas and high-grade astrocytomas correlates with cellularity. MATERIALS AND METHODS: Echo-planar diffusion-weighted magnetic resonance (MR) images obtained in 11 patients with brain lymphomas (19 lesio ... Full text Link to item Cite

Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.

Journal Article J Clin Oncol · May 1, 2002 PURPOSE: We conducted a phase II trial of carmustine (BCNU) plus the O(6)-alkylguanine-DNA alkyltransferase inhibitor O(6)-benzylguanine (O(6)-BG) to define the activity and toxicity of this regimen in the treatment of adults with progressive or recurrent ... Full text Link to item Cite

Multiple sclerosis: diffusion tensor MR imaging for evaluation of normal-appearing white matter.

Journal Article Radiology · March 2002 PURPOSE: To determine whether the normal-appearing white matter (NAWM) regions surrounding and remote from multiple sclerosis (MS) plaques have abnormal diffusional anisotropy and to compare anisotropy maps with apparent diffusion coefficient (ADC) maps fo ... Full text Link to item Cite

Comparison of permeability in high-grade and low-grade brain tumors using dynamic susceptibility contrast MR imaging.

Journal Article AJR Am J Roentgenol · March 2002 OBJECTIVE: The purpose of this study was to compare permeability measurements in high-grade and low-grade glial neoplasms using a T2(*)-weighted method. Our hypothesis was that permeability measurements using a T2(*)-weighted technique would show permeabil ... Full text Link to item Cite

Diffusion-weighted imaging in a patient with vertebral and epidural abscesses.

Journal Article AJNR Am J Neuroradiol · March 2002 In this report, we describe the appearance of the spinal vertebral body and epidural abscesses in a patient who underwent diffusion-weighted imaging of the spine and CT-guided aspiration of one of the abscesses. The abscesses were hyperintense relative to ... Link to item Cite

Aging and attentional guidance during visual search: functional neuroanatomy by positron emission tomography.

Journal Article Psychol Aging · March 2002 Positron emission tomography (PET) was used to examine adult age differences in neural activation during visual search. Target detection was less accurate for older adults than for younger adults, but both age groups were successful in using color to guide ... Full text Link to item Cite

Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas.

Journal Article J Clin Oncol · March 1, 2002 PURPOSE: To assess the efficacy and toxicity of intraresection cavity (131)I-labeled murine antitenascin monoclonal antibody 81C6 and determine its true response rate among patients with newly diagnosed malignant glioma. PATIENTS AND METHODS: In this phase ... Full text Link to item Cite

Dynamic CT perfusion imaging with acetazolamide challenge for the preprocedural evaluation of a patient with symptomatic middle cerebral artery occlusive disease.

Journal Article AJNR Am J Neuroradiol · February 2002 We describe the use of a CT-based method of cerebral perfusion imaging, dynamic CT perfusion imaging, for the pre- and postprocedural assessment of cerebral blood flow in a patient with symptomatic middle cerebral artery occlusive disease who underwent bal ... Link to item Cite

Hypointense thrombus on T2-weighted MR imaging: a potential pitfall in the diagnosis of dural sinus thrombosis.

Journal Article Eur J Radiol · February 2002 PURPOSE: To determine the frequency of hypointense appearance of dural sinus thrombosis on T2-weighted images, which may mimic a normal flow void, and when possible correlate with appearance on T1-weighted images. METHODS AND MATERIALS: Retrospective revie ... Full text Link to item Cite

Tensor diffusion imaging in B12 leukoencephalopathy.

Journal Article J Comput Assist Tomogr · 2002 Anisotropy measurements were obtained from periventricular foci of T2 prolongation and adjacent normal-appearing white matter in a case of B12 leukoencephalopathy. Measurements were compared with mean values from two age-matched control subjects. Anisotrop ... Full text Link to item Cite

CT perfusion scanning with deconvolution analysis: pilot study in patients with acute middle cerebral artery stroke.

Journal Article Radiology · January 2002 PURPOSE: To measure mean cerebral blood flow (CBF) in ischemic and nonischemic territories and in low-attenuation regions in patients with acute stroke by using deconvolution-derived hemodynamic imaging. MATERIALS AND METHODS: Twelve patients with acute mi ... Full text Link to item Cite

Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions.

Journal Article Prog Brain Res · 2002 Whether or not severe febrile seizures in infancy cause hippocampal injury and subsequent medial temporal sclerosis is an often debated question in epilepsy. Recent magnetic resonance imaging (MRI) of infants suffering from febrile seizures has provided pr ... Full text Link to item Cite

Glioneuronal tumors of the central nervous system.

Journal Article Brain Tumor Pathol · 2002 Advances in the immunohistochemical detection of neuron-specific and neuronal-associated antigens have resulted in the discovery of neuronal elements in certain primary human brain tumors. The results have been not only to expand what neuropathologists com ... Full text Link to item Cite

Normal structures in the intracranial dural sinuses: delineation with 3D contrast-enhanced magnetization prepared rapid acquisition gradient-echo imaging sequence.

Journal Article AJNR Am J Neuroradiol · 2002 BACKGROUND AND PURPOSE: The potential pitfalls in the diagnosis of dural sinus thrombosis include the presence of arachnoid granulations, intrasinus fibrotic bands (so-called septa), and hypoplasia or aplasia of the dural sinuses. The purpose of this study ... Link to item Cite

Subcortical white matter lesions and functional impairment in geriatric depression.

Journal Article Depress Anxiety · 2002 Geriatric depression is associated with significant functional impairment. There is also growing evidence linking vascular brain changes to depression in late life. We sought to examine the relationship between cerebrovascular disease and impairment in bas ... Full text Link to item Cite

Human herpesvirus 6 limbic encephalitis after stem cell transplantation.

Journal Article Ann Neurol · November 2001 Central nervous system complications are common in stem cell transplant recipients, but selective involvement of the medial temporal area is unusual. The 5 patients reported here presented after stem cell transplantation with increased hippocampal T2 signa ... Full text Link to item Cite

Phase I study of Gliadel wafers plus temozolomide in adults with recurrent supratentorial high-grade gliomas.

Journal Article Neuro Oncol · October 2001 Both Gliadel wafers [1,3-bis(2-chloroethyl)-1-nitrosourea] and temozolomide (TEMO) have been shown in independent studies to prolong survival of patients with recurrent malignant glioma following surgery and radiotherapy. On the basis of preclinical eviden ... Full text Link to item Cite

Quantitative assessment of diffusion abnormalities in posterior reversible encephalopathy syndrome.

Journal Article AJNR Am J Neuroradiol · September 2001 BACKGROUND AND PURPOSE: Previous studies have shown that lesions in posterior reversible encephalopathy syndrome are often isointense on diffusion-weighted MR images. We hypothesized that 1) apparent diffusion coefficient (ADC) maps using various threshold ... Link to item Cite

MRI correlates of suicide attempt history in unipolar depression.

Journal Article Biol Psychiatry · August 15, 2001 BACKGROUND: Suicide represents a major health problem in the United States, and prediction of suicide attempts is difficult. No structural neuroimaging studies have been done to specifically examine findings in patients who have attempted suicide. The obje ... Full text Link to item Cite

(18)F-fluorodeoxyglucose positron emission tomography and MR imaging findings in Rasmussen encephalitis.

Journal Article AJNR Am J Neuroradiol · August 2001 BACKGROUND AND PURPOSE: Rasmussen encephalitis is a chronic, progressive encephalitis that manifests as an abrupt-onset, intractable seizure disorder in previously developmentally normal children. The objectives of the current study were to characterize th ... Link to item Cite

Evidence of white matter tract disruption in MRI hyperintensities.

Journal Article Biol Psychiatry · August 1, 2001 BACKGROUND: Diffusion tensor imaging (DTI) of brain tissue measures the apparent diffusion coefficient (ADC), or isotropic diffusion, and anisotropy, or diffusion as influenced by tissue structure. We hypothesized that hyperintensities, when compared with ... Full text Link to item Cite

March 2000: A 16 year old female with a cerebellar mass.

Journal Article Brain Pathol · July 2001 The March COM: A 16 year old female presented with headaches and cerebellar dysfunction. MR images showed a mass lesion of the right cerebellar hemisphere with mass effect on the medulla. The mass exhibited a striated pattern of alternating isointense and ... Link to item Cite

Medial orbital frontal lesions in late-onset depression.

Journal Article Biol Psychiatry · May 1, 2001 BACKGROUND: Early studies using magnetic resonance (MR) imaging suggested that subcortical vascular changes are more prevalent in late-life depression and that they may play a role in the pathophysiology of depression. Studying the location of the lesion r ... Full text Link to item Cite

Cerebral abscesses: investigation using apparent diffusion coefficient maps.

Journal Article Neuroradiology · May 2001 The combination of high signal and reduced apparent diffusion coefficients (ADC) within abscesses on diffusion-weighted MRI (DWI) has been reported as characteristic of abscesses, and useful for distinguishing them from cystic or necrotic neoplasms. To ass ... Full text Link to item Cite

Increased brain apparent diffusion coefficient in children with neurofibromatosis type 1.

Journal Article Radiology · May 2001 PURPOSE: To describe the changes in brain water diffusibility in five anatomic locations in children with neurofibromatosis type 1 (NF 1) compared with these changes in control subjects and to describe the water diffusibility changes associated with hyperi ... Full text Link to item Cite

Long term response in a patient with neoplastic meningitis secondary to melanoma treated with (131)I-radiolabeled antichondroitin proteoglycan sulfate Mel-14 F(ab')(2): a case study.

Journal Article Cancer · May 1, 2001 Even with novel chemotherapeutic agents and external beam radiation therapy, the prognosis of neoplastic meningitis secondary to malignant melanoma is still dismal. The authors report a case study of a 46-year-old white female who presented with progressiv ... Link to item Cite

Use of exponential diffusion imaging to determine the age of ischemic infarcts.

Journal Article J Neuroimaging · April 2001 Diffusion-weighted magnetic resonance imaging (DWI) detects acute ischemic infarcts with high lesion conspicuity. Determination of infarct age is difficult on DWI alone because infarct signal intensity (SIinfarct) on DWI is influenced by T2 properties ("T2 ... Full text Link to item Cite

Practical injection-rate CT perfusion imaging: deconvolution-derived hemodynamics in a case of stroke.

Journal Article Neuroradiology · March 2001 Previously reported methods of dynamic, contrast-enhanced, CT perfusion imaging in acute stroke have been promising but substantially limited by their dependence on very rapid rates of injection (typically 10-20 ml/s in an arm vein). Newly available deconv ... Full text Link to item Cite

Evaluation of white matter anisotropy in Krabbe disease with diffusion tensor MR imaging: initial experience.

Journal Article Radiology · March 2001 PURPOSE: To compare diffusion tensor magnetic resonance imaging with conventional T2-weighted imaging for evaluation of white matter changes in patients with Krabbe disease. MATERIALS AND METHODS: In eight patients with Krabbe disease and eight age-matched ... Full text Link to item Cite

Serial MR imaging of pineal cysts: implications for natural history and follow-up.

Journal Article AJR Am J Roentgenol · March 2001 OBJECTIVE: The purpose of this study was to examine the frequency of change in size of pineal cysts on serial MR studies. MATERIALS AND METHODS: Thirty-two patients (19 females, 13 males) with a diagnosis of pineal cyst at any time who underwent brain MR i ... Full text Link to item Cite

Magnetic resonance imaging applications in the evaluation of tumor angiogenesis.

Journal Article Semin Radiat Oncol · January 2001 Angiogenesis, the growth of new blood vessels, is a critical component in the development of solid tumors. Over the last decade, progress in the study of the biology of angiogenesis has led to identification of a large number of molecules that promote, par ... Full text Link to item Cite

Analysis of normal-appearing white matter in multiple sclerosis: comparison of diffusion tensor MR imaging and magnetization transfer imaging.

Journal Article AJNR Am J Neuroradiol · 2001 BACKGROUND AND PURPOSE: Our purpose was to compare diffusion tensor MR and magnetization transfer imaging in assessing normal-appearing white matter (WM) regions in multiple sclerosis (MS). METHODS: Diffusion tensor, magnetization transfer, and conventiona ... Link to item Cite

18F-fluorodeoxyglucose positron emission tomography and MR imaging findings in rasmussen encephalitis

Journal Article American Journal of Neuroradiology · 2001 BACKGROUND AND PURPOSE: Rasmussen encephalitis is a chronic, progressive encephalitis that manifests as an abrupt-onset, intractable seizure disorder in previously developmentally normal children. The objectives of the current study were to characterize th ... Cite

Nonischemic causes of hyperintense signals on diffusion-weighted magnetic resonance images: a pictorial essay.

Journal Article Can Assoc Radiol J · December 2000 A number of entities other than acute cerebral infarction can produce bright signal intensity on diffusion-weighted magnetic resonance images, and an understanding of the range of possible diagnoses for these hyperintense lesions is important for radiologi ... Link to item Cite

Vertex epidural hematomas: imaging findings and diagnostic pitfalls.

Journal Article Eur J Radiol · December 2000 PURPOSE: Our purpose was to show the computed tomography (CT) and magnetic resonance (MR) imaging features of vertex epidural hematomas (EDHs) and emphasize pitfalls in the diagnosis of this entity. SUBJECTS AND METHODS: The neuroradiologic studies of four ... Full text Link to item Cite

Phase I trial results of iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with newly diagnosed malignant gliomas.

Journal Article J Clin Oncol · November 15, 2000 PURPOSE: To determine the maximum-tolerated dose (MTD) of iodine-131 ((131)I)-labeled 81C6 antitenascin monoclonal antibody (mAb) administered clinically into surgically created resection cavities (SCRCs) in malignant glioma patients and to identify any ob ... Full text Link to item Cite

Assessment of vasogenic edema in eclampsia using diffusion imaging.

Journal Article Neuroradiology · November 2000 We qualitatively assessed the regional distribution of vasogenic edema in a case of postpartum eclampsia. Although diffusion-weighted imaging showed no abnormalities, bilateral high signal was seen on T2-weighted images and apparent diffusion coefficient ( ... Full text Link to item Cite

Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.

Journal Article J Clin Oncol · October 15, 2000 PURPOSE: The major mechanism of resistance to alkylnitrosourea therapy involves the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT), which removes chloroethylation or methylation damage from the O(6) position of guanine. O(6)-benzylguanine ... Full text Link to item Cite

The effect of aging on the apparent diffusion coefficient of normal-appearing white matter.

Journal Article AJR Am J Roentgenol · August 2000 OBJECTIVE: The purpose of our study was to test the hypothesis that the apparent diffusion coefficient (ADC) of normal-appearing white matter increases with advancing age. SUBJECTS AND METHODS: We selected 38 patients with normal MR imaging findings from 3 ... Full text Link to item Cite

Magnetic resonance imaging in patients with central nervous system pathology: a comparison of OptiMARK (Gd-DTPA-BMEA) and Magnevist (Gd-DTPA).

Journal Article Invest Radiol · July 2000 RATIONALE AND OBJECTIVES: The objective of the two pivotal phase 3 studies was to evaluate the safety and efficacy of OptiMARK (Gd-DTPA-bis(methoxyethylamide) [Gd-DTPA-BMEA]) compared with Magnevist (Gd-DTPA) in magnetic resonance imaging of the central ne ... Full text Link to item Cite

Gliomas of the optic nerve: histological, immunohistochemical (MIB-1 and p53), and MRI analysis.

Journal Article Acta Neuropathol · May 2000 Gliomas of the optic nerve, although typically of pilocytic (WHO grade I) histology, can present within the spectrum of astrocytic neoplasia including glioblastoma (WHO grade IV). In certain cases, histologic features alone make the distinction between pil ... Full text Link to item Cite

Perfusion MR imaging of brain neoplasms.

Journal Article AJR Am J Roentgenol · April 2000 Full text Link to item Cite

Comparison of patient age with MR imaging features of gangliogliomas.

Journal Article AJR Am J Roentgenol · March 2000 OBJECTIVE: The purpose of this study was to compare MR imaging features of gangliogliomas in children less than 10 years old with those seen in patients at least 10 years old. MATERIALS AND METHODS: Our study population consisted of 15 female patients and ... Full text Link to item Cite

Dosimetry and dose-response relationships in newly diagnosed patients with malignant gliomas treated with iodine-131-labeled anti-tenascin monoclonal antibody 81C6 therapy.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2000 PURPOSE: The objective of this study was to perform the dosimetry and evaluate the dose-response relationships in newly diagnosed patients with malignant brain tumors treated by direct injections of (131)I-labeled 81C6 monoclonal antibody (MAb) into surgic ... Full text Link to item Cite

Centennial dissertation. Honoring Arthur W. Goodspeed, MD and James B. Bullitt, MD. CT and MR imaging and nontraumatic neurologic emergencies.

Journal Article AJR Am J Roentgenol · February 2000 This review has highlighted some of the disease processes that produce diagnostic difficulty in the emergency neuroradiology setting. Because radiologists are often the first individuals to consider these entities, they must be familiar with the clinical f ... Full text Link to item Cite

Brain morphological changes and early marijuana use: a magnetic resonance and positron emission tomography study.

Journal Article J Addict Dis · 2000 BACKGROUND: The focus of this report is on the possible role that the age of first use of marijuana may play on brain morphology and function. METHODS: Magnetic resonance imaging (MRI) and positron emission tomography (PET) were utilized to study 57 subjec ... Full text Link to item Cite

Diffusion-weighted MR imaging in acute stroke: theoretic considerations and clinical applications.

Journal Article AJR Am J Roentgenol · December 1999 The major clinical use of diffusion-weighted imaging to date has been in evaluation of cerebral infarction, at which it excels. However, diffusion-weighted imaging has also shown promise for other applications, ranging from quantitative analysis of biologi ... Full text Link to item Cite

Emergency MR imaging of the central nervous system

Journal Article Emergency Radiology · December 1, 1999 Magnetic resonance (MR) of the central nervous system has few, but important indications for use in the acute setting. This report reviews the few true current clinical indications for emergency MR imaging, including ruling out spinal cord compression, vas ... Full text Cite

White matter lesion contrast in fast spin-echo fluid-attenuated inversion recovery imaging: effect of varying effective echo time and echo train length.

Journal Article AJR Am J Roentgenol · October 1999 OBJECTIVE: Our aim was to determine whether the contrast between white matter lesions and normal-appearing white matter in fast spin-echo fluid-attenuated inversion recovery (FLAIR) images can be improved by lengthening the effective TE and the echo train ... Full text Link to item Cite

Aging and recognition memory: changes in regional cerebral blood flow associated with components of reaction time distributions.

Journal Article J Cogn Neurosci · September 1999 We used H(2)15O positron emission tomography (PET) to measure age-related changes in regional cerebral blood flow (rCBF) during a verbal recognition memory task. Twelve young adults (20 to 29 years) and 12 older adults (62 to 79 years) participated. Separa ... Full text Link to item Cite

Recent advances in imaging of cerebrovascular disease.

Journal Article Radiol Clin North Am · May 1999 The recent advances made in CT and MR imaging have led to increased accuracy in making a number of diagnoses in the emergency room setting. Increasingly, radiologists are asked to perform these studies and accurately interpret the findings, which often hav ... Full text Link to item Cite

Irinotecan therapy in adults with recurrent or progressive malignant glioma.

Journal Article J Clin Oncol · May 1999 PURPOSE: To determine the activity, toxicity, and pharmacokinetics of irinotecan (CPT-11, Camptosar; Pharmacia & Upjohn, Kalamazoo, MI) in the treatment of adults with progressive, persistent, or recurrent malignant glioma. PATIENTS AND METHODS: Patients w ... Full text Link to item Cite

Malignant supratentorial ganglioglioma (ganglion cell-giant cell glioblastoma): a case report and review of the literature.

Journal Article Arch Pathol Lab Med · April 1999 BACKGROUND: From both epidemiologic and pathologic viewpoints, gangliogliomas exhibiting components of giant cell glioblastomas are extraordinary neoplasms. We report herein the case of a 6-year-old girl who presented initially with a World Health Organiza ... Full text Link to item Cite

Gangliogliomas: characterization by registered positron emission tomography-MR images.

Journal Article AJR Am J Roentgenol · April 1999 OBJECTIVE: The purpose of this study was to correlate 18F-fluorodeoxyglucose positron emission tomography (PET) and MR imaging features of cerebral gangliogliomas before and after PET-MR image registration. CONCLUSION: After registration of PET and MR imag ... Full text Link to item Cite

Adult age differences in the functional neuroanatomy of verbal recognition memory.

Journal Article Hum Brain Mapp · 1999 Adult age differences are frequently observed in the performance of memory tasks, but the changes in neural function mediating these differences are largely unknown. We used (H2)15O positron emission tomography (PET) to measure changes in regional cerebral ... Full text Link to item Cite

Anti-phospholipid antibodies in patients with multiple sclerosis and MS-like illnesses: MS or APS?

Journal Article Lupus · 1999 OBJECTIVE: To describe the frequency, clinical, and laboratory features of patients diagnosed with multiple sclerosis (MS) or MS-like illnesses (MSL) among a large, prospectively followed cohort of anti-phospholipid antibody (aPL)-positive patients. METHOD ... Full text Link to item Cite

MR arteriography of intracranial circulation.

Journal Article AJR Am J Roentgenol · December 1998 Full text Link to item Cite

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

Journal Article J Clin Oncol · December 1998 PURPOSE: We evaluated the response to Temodal (Schering-Plough Research Institute, Kenilworth, NJ) of patients with newly diagnosed malignant glioma, as well as the predictive value of quantifying tumor DNA mismatch repair activity and O6-alkylguanine-DNA ... Full text Link to item Cite

Familial leukoencephalopathy in bipolar disorder.

Journal Article Am J Psychiatry · November 1998 OBJECTIVE: Imaging studies of patients with bipolar disorder demonstrate changes in deep white matter and subcortical gray nuclei that are seen as focal hyperintensities on T2-weighted magnetic resonance imaging (MRI). The objective of this study was to ex ... Full text Link to item Cite

Recurrent thrombosis of the superior vena cava associated with activated protein C resistance: imaging findings.

Journal Article Pediatr Radiol · August 1998 The purpose of this report is to describe imaging findings in activated protein C resistance, a hereditary cause of recurrent thrombosis. The case described was unusual in that a neonate was affected, whereas the vast majority of cases occur in adulthood. ... Full text Link to item Cite

Schistosomal myelitis: findings at MR imaging.

Journal Article Eur J Radiol · July 1998 Schistosomal spinal cord involvement is a rare complication of infection by Schistosoma mansoni. This work reports the MR imaging findings in a patient with schistosomal myelitis involving the lower spinal cord and conus medullaris. MR imaging showed a foc ... Full text Link to item Cite

Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas: phase I trial results.

Journal Article J Clin Oncol · June 1998 PURPOSE: To determine the maximum-tolerated dose (MTD) of iodine 131 (131I)-labeled 81C6 monoclonal antibody (mAb) in brain tumor patients with surgically created resection cavities (SCRCs) and to identify any objective responses to this treatment. METHODS ... Full text Link to item Cite

Phase II study of carboplatin (CBDCA) in progressive low-grade gliomas.

Journal Article Neurosurg Focus · April 15, 1998 In this study, the authors sought to investigate the response rate and toxicity of carboplatin in patients with progressive low-grade glioma (LGG). Thirty-two patients with progressive LGG were treated with carboplatin at a dosage of 560 mg/m(2). Treatment ... Full text Link to item Cite

Cerebrovascular disease risk factors: neuroradiologic findings in patients with activated protein C resistance.

Journal Article Radiology · April 1998 PURPOSE: To assess the patterns of abnormal neuroradiologic findings in patients with a hypercoagulable state related to activated protein C (APC) resistance. MATERIALS AND METHODS: Records in 23 patients with a hypercoagulable state related to APC resista ... Full text Link to item Cite

Antiphospholipid antibodies: findings at arteriography.

Journal Article AJNR Am J Neuroradiol · April 1998 PURPOSE: The purpose of this study was to determine the frequency and types of abnormalities at arteriography in patients with antiphospholipid antibodies (APA) and ischemic cerebrovascular events. METHODS: Twenty-three patients with APA and ischemic cereb ... Link to item Cite

Dural sinus thrombosis associated with activated protein C resistance: MR imaging findings and proband identification.

Journal Article AJR Am J Roentgenol · February 1998 OBJECTIVE: The purpose of this study was to report the association of dural sinus thrombosis with a hypercoagulable state associated with activated protein C resistance. CONCLUSION: In our small study population, hemorrhagic venous infarction was common (t ... Full text Link to item Cite

Disseminated thrombosis in primary antiphospholipid syndrome: MR findings.

Journal Article Eur J Radiol · February 1998 We report the MR imaging findings in a patient with primary antiphospholipid syndrome, adrenal infarction and widespread thrombosis involving abdominal, pelvic, and pulmonary vessels. This syndrome should be suspected in patients with thromboses and organ ... Full text Link to item Cite

Metastatic rhabdomyosarcoma presenting as intracranial hemorrhage: imaging findings.

Journal Article Eur J Radiol · February 1998 The CNS is rarely the first site of metastasis for rhabdomyosarcoma. CNS involvement is uncommon, and usually seen as leptomeningeal spread after development of pulmonary metastases. We present the imaging findings in a 13-year-old boy in whom a large intr ... Full text Link to item Cite

Systemic thrombosis in patients with antiphospholipid antibodies: lesion distribution and imaging findings.

Journal Article AJR Am J Roentgenol · February 1998 OBJECTIVE: The purpose of this study was to determine the patterns of non-CNS thromboses in patients with a hypercoagulable state associated with antiphospholipid antibodies (APA). MATERIALS AND METHODS: A search of our institution's clinical coagulation a ... Full text Link to item Cite

Thoracic imaging features of patients with antiphospholipid antibodies.

Journal Article J Comput Assist Tomogr · 1998 PURPOSE: Our aim was to determine the thoracic manifestations of patients with antiphospholipid antibodies (APAs). METHOD: We performed a retrospective review of the clinical records and thoracic imaging studies of 88 patients (63 women, 25 men; mean age 4 ... Full text Link to item Cite

Nontraumatic neurologic emergencies: Imaging findings

Journal Article Emergency Radiology · December 1, 1997 For some common nontraumatic neurologic conditions encountered in the emergency setting, the clinical history is important in helping the radiologist to choose the most appropriate imaging study. The clinical and radiologic features of four such conditions ... Full text Cite

Brain infarction in young adults: etiology and imaging findings.

Journal Article AJR Am J Roentgenol · October 1997 The causes of stroke in young adults differ substantially from those in older adults. In many instances, the diagnosis can be made by taking a clinical history and performing laboratory studies (e.g., in patients who have multiple thromboses associated wit ... Full text Link to item Cite

Brain and spine imaging findings in AIDS patients.

Journal Article Radiol Clin North Am · September 1997 Central nervous system complications in AIDS patients are common and often the cause of severe morbidity and mortality. Most symptomatic central nervous system complications in AIDS patients involve the brain, principally in the form of HIV encephalitis, v ... Link to item Cite

Typical and atypical MR imaging features of intracranial epidermoid tumors.

Journal Article AJR Am J Roentgenol · September 1997 OBJECTIVE: We categorized the MR imaging characteristics of intracranial epidermoid tumors. MATERIALS AND METHODS: MR images from 23 cases of intracranial epidermoid tumors were reviewed retrospectively. Signal intensities of tumor relative to surrounding ... Full text Link to item Cite

Pictorial review: magnetic resonance angiography of arterial variants at the Circle of Willis.

Journal Article Clin Radiol · June 1997 As intracranial MR angiography becomes more widely used and spatial resolution improves, anomalies at the Circle of Willis which have been previously well described on angiographic studies and anatomic dissections will become more frequently appreciated by ... Full text Link to item Cite

Craniocerebral plasmacytoma: MR features.

Journal Article AJNR Am J Neuroradiol · February 1997 We report the MR imaging findings in two patients with solitary craniocerebral plasmacytoma, a benign plasma cell tumor that can arise from the skull, the dura, or, rarely, the brain. In both patients, the lesion was extraaxial and nearly isointense with g ... Link to item Cite

Selective and divided visual attention: age-related changes in regional cerebral blood flow measured by H2(15)O PET.

Journal Article Hum Brain Mapp · 1997 Regional cerebral blood flow (rCBF) was measured using H2(15)O and positron emission tomography (PET) to test the hypothesis that age-related changes in the pattern of rCBF activation would be greater under divided attention conditions than under selective ... Full text Link to item Cite

Patients with antiphospholipid antibodies: CT and MR findings of the brain.

Journal Article AJR Am J Roentgenol · December 1996 OBJECTIVE: The purpose of this study was to determine the spectrum of neuroradiologic findings in patients with antiphospholipid antibodies (APA) and to compare findings in systemic lupus erythematosus (SLE) and non-SLE patients. MATERIALS AND METHODS: We ... Full text Link to item Cite

Reversible leukoencephalopathy associated with graft-versus-host disease: MR findings.

Journal Article AJNR Am J Neuroradiol · August 1996 Ten weeks after undergoing bone marrow transplantation for metastatic lymphoma of the parotid gland, a 9-year-old girl became disoriented and had tremor and myoclonus in the context of graft-versus-host disease (GVHD). MR images showed abnormal signal prim ... Link to item Cite

MRI in hemiballismus due to subthalamic nucleus hemorrhage: an unusual complication of liver transplantation.

Journal Article Neuroradiology · May 1996 A 60-year-old man developed hemiballismus due to an intracranial hemorrhage involving the subthalamic nucleus 8 weeks after orthotopic liver transplantation. The hemorrhage was thought to be due to alterations in cerebral blood flow following a period of h ... Full text Link to item Cite

Wegener granulomatosis: CT and MR findings.

Journal Article AJNR Am J Neuroradiol · April 1996 PURPOSE: To demonstrate the spectrum of CT and MR imaging findings in patients with Wegener granulomatosis and to determine how often these findings could be attributed to either direct extension from paranasal or orbital disease sites, remote granulomas, ... Link to item Cite

Spinal angiolipomas: MR features.

Journal Article AJNR Am J Neuroradiol · April 1996 PURPOSE: To determine the MR features of spinal angiolipomas and to compare these findings with their histologic appearance. METHODS: The MR examinations of three patients with surgically proved angiolipomas were reviewed for tumor location and extent, sig ... Link to item Cite

Orbital involvement by Wegener's granulomatosis: imaging findings.

Journal Article AJR Am J Roentgenol · April 1996 OBJECTIVE: The purpose of this study was to define patterns of Wegener's granulomatosis (WG) orbital disease involvement. SUBJECTS AND METHODS: We evaluated the orbital examinations of 14 WG patients (CT for nine, MR imaging for three, and both CT and MR i ... Full text Link to item Cite

Adult age differences in regional cerebral blood flow during visual world identification: evidence from H215O PET.

Journal Article Neuroimage · April 1996 We used H215O PET to investigate adult age differences in regional cerebral blood flow (rCBF) during the performance of a visual word identification task. The study participants were 20 healthy, right-handed men: 10 young adults between 18 and 27 years of ... Full text Link to item Cite

Delayed development of sensorineural hearing loss after neonatal hyperbilirubinemia: a case report with brain magnetic resonance imaging.

Journal Article Dev Med Child Neurol · March 1996 Sensorineural hearing loss has long been known to be a clinical consequence of kernicterus. Brainstem auditory evoked potentials (BAEPs) that occur in hyperbilirubinemic infants, can be reversed in the neonatal period by exchange transfusion. The case was ... Full text Link to item Cite

Cerebral infarction associated with Kearns-Sayre syndrome-related cardiomyopathy.

Journal Article Neurology · March 1996 We present the clinical and neuroradiologic findings of a 31-year-old man with Kearns-Sayre syndrome- related dilated cardiomyopathy who experienced a left middle cerebral artery territory stroke, thought to be due to cardiogenic embolism. The rate of clin ... Full text Link to item Cite

Spontaneous vertebral dissection: clinical, conventional angiographic, CT, and MR findings.

Journal Article J Comput Assist Tomogr · 1996 OBJECTIVE: The purpose of this study was to determine if typical clinical and neuroradiologic patterns exist in patients with spontaneous vertebral artery (VA) dissection. MATERIALS AND METHODS: The medical records and neuroradiologic examinations of 14 pa ... Full text Link to item Cite

Neuroradiologic findings in polyarteritis nodosa.

Journal Article AJNR Am J Neuroradiol · 1996 PURPOSE: To demonstrate the neuroradiologic findings in patients with polyarteritis nodosa. METHODS: A review of hospital records for a 10-year period revealed 50 patients with a discharge diagnosis of polyarteritis nodosa. Thirteen patients had undergone ... Link to item Cite

A hemodialysis patient with excruciating back pain

Journal Article Seminars in Dialysis · January 1, 1996 Full text Cite

Dissection of the internal carotid and vertebral arteries: imaging features.

Journal Article AJR Am J Roentgenol · November 1995 Dissection of either the internal carotid artery or the vertebral artery (cervicocephalic arterial dissection) was once considered uncommon. However, in the past few decades, it has been increasingly recognized as a cause of stroke in young and middle-aged ... Full text Link to item Cite

Anatomic distribution of venous thrombosis in patients with antiphospholipid antibody: imaging findings.

Journal Article AJR Am J Roentgenol · August 1995 OBJECTIVE: Antiphospholipid antibodies are immunoglobulins that cross-react with phospholipid within cell membranes. These antibodies have been associated with a hypercoagulable state manifested by early stroke, frequent arterial and venous thromboses, rec ... Full text Link to item Cite

Adrenal hemorrhage in patients with primary antiphospholipid syndrome: imaging findings.

Journal Article AJR Am J Roentgenol · August 1995 OBJECTIVE: The primary antiphospholipid syndrome consists of recurrent thromboses, early stroke, recurrent fetal loss, and livedo reticularis in patients with antiphospholipid antibodies and without systemic lupus erythematosus. The purpose of this study w ... Full text Link to item Cite

MR of the brain in mitochondrial myopathy.

Journal Article AJNR Am J Neuroradiol · May 1995 PURPOSE: To determine the spectrum of MR findings in patients with mitochondrial myopathy and correlate them with central nervous system symptoms and signs. METHODS: We performed a prospective evaluation of the MR findings of eight patients with mitochondr ... Link to item Cite

Neuroradiologic findings in fucosidosis, a rare lysosomal storage disease.

Journal Article AJNR Am J Neuroradiol · April 1995 Fucosidosis is a rare lysosomal storage disorder with the clinical features of mental retardation, cardiomegaly, dysostosis multiplex, progressive neurologic deterioration, and early death. The neuroradiologic findings in two patients are reported, and inc ... Link to item Cite

Shadow cells in an intracranial dermoid cyst.

Journal Article Arch Pathol Lab Med · April 1995 A case of an intracranial dermoid cyst containing shadow cells is presented. This case expands the group of lesions in which shadow cells, indicative of hair matrical differentiation, have been described. ... Link to item Cite

Hemiballismus: CT and MR findings.

Journal Article J Comput Assist Tomogr · 1995 OBJECTIVE: Our aim was to determine the frequency with which a lesion responsible for hemiballismus was detectable on CT and MR examinations. MATERIALS AND METHODS: The CT and MR examinations of six patients with hemiballismus were reviewed. Three patients ... Link to item Cite

Post-traumatic epidermoid cyst: CT appearance.

Other J Comput Assist Tomogr · 1995 We report development of an intracranial epidermoid cyst 2 years after a depressed skull fracture. The epidermoid cyst is presumed to be the result of introduction of epidermal elements at the time of trauma. Post-traumatic intracranial epidermoid cysts ar ... Full text Link to item Cite

Supratentorial ependymomas and subependymomas: CT and MR appearance.

Journal Article J Comput Assist Tomogr · 1995 OBJECTIVE: Our goal was to characterize the CT and MR features of supratentorial ependymomas and subependymomas. MATERIALS AND METHODS: The CT or MRI examinations of 11 supratentorial ependymomas (average patient age: 16 years) and 3 supratentorial subepen ... Full text Link to item Cite

Internal carotid artery dissection associated with pituitary apoplexy: MR findings.

Journal Article J Comput Assist Tomogr · 1995 Pituitary apoplexy almost invariably occurs following hemorrhage into a pituitary neoplasm. We report a case in which pituitary apoplexy occurred in the setting of, and probably secondary to, dissection of the internal carotid artery. ... Full text Link to item Cite

Exercise-related dissection of craniocervical arteries: CT, MR, and angiographic findings.

Journal Article J Comput Assist Tomogr · 1995 OBJECTIVE: Our goal was to demonstrate the spectrum of neuroradiologic (CT, MR, and angiographic) findings in craniocervical arterial dissection (CAD) related to exercise or sporting activities and compare the diagnostic utility of CT, MRI, and MR angiogra ... Full text Link to item Cite

Neuroradiologic findings in fucosidosis, a rare lysosomal storage disease

Journal Article American Journal of Neuroradiology · January 1, 1995 Fucosidosis is a rare lysosomal storage disorder with the clinical features of mental retardation, cardiomegaly, dysostosis multiplex, progressive neurologic deterioration, and early death. The neuroradiologic findings in two patients are reported, and inc ... Cite

Lupus-related myelitis: serial MR findings.

Journal Article AJNR Am J Neuroradiol · November 1994 PURPOSE: To correlate the MR findings in transverse myelitis secondary to systemic lupus erythematosus with clinical findings during disease exacerbation and remission. METHODS: Four patients (ages 33 to 47 years) with episodes of transverse myelitis secon ... Link to item Cite

Antiphospholipid antibodies in patients without systemic lupus erythematosus: neuroradiologic findings.

Journal Article Radiology · August 1994 PURPOSE: To study neuroradiologic findings in patients with hypercoagulability due to antiphospholipid antibodies (APAs). MATERIALS AND METHODS: Retrospective review of abnormal angiographic, computed tomographic, and magnetic resonance imaging findings wa ... Full text Link to item Cite

Hemiballismus.

Journal Article AJNR Am J Neuroradiol · August 1994 Link to item Cite

Dural sinus thrombosis and venous infarction associated with antiphospholipid antibodies: MR findings.

Journal Article J Comput Assist Tomogr · 1994 OBJECTIVE: Our goal was to describe the neuroradiologic findings in hemorrhagic venous infarction related to a hypercoagulable state caused by antiphospholipid antibodies (aPA). MATERIALS AND METHODS: Magnetic resonance imaging was performed on two patient ... Full text Link to item Cite

MR diagnosis of Creutzfeldt-Jakob disease: significance of high signal intensity of the basal ganglia.

Journal Article AJR Am J Roentgenol · January 1994 OBJECTIVE: Creutzfeldt-Jakob disease is a rare dementing illness that usually affects older adults. Currently, neuroradiologic examinations play a minor role in the diagnosis of Creutzfeldt-Jakob disease. Several single case reports have noted a distinctiv ... Full text Link to item Cite

Spinal dural arteriovenous fistula: demonstration using phase contrast MRA.

Journal Article J Comput Assist Tomogr · 1994 Contrast angiography is the standard means of diagnosing spinal dural arteriovenous fistulas. We present a patient in whom a spinal dural arteriovenous fistula was demonstrated on phase contrast MR angiography. ... Full text Link to item Cite

CT and MRI evaluation of intracranial trauma

Journal Article Imaging · December 1, 1993 Cite

Lupus-related myelopathy: report of three cases and review of the literature.

Journal Article J Neurol Neurosurg Psychiatry · September 1992 Transverse myelopathy is an uncommon complication of systemic lupus erythematosus (SLE). Three patients with SLE are reported who developed transverse myelopathy, including the neuropathological findings in one patient on whom necropsy was performed. Parap ... Full text Link to item Cite

Tuberous sclerosis.

Journal Article Am Fam Physician · February 1991 Tuberous sclerosis is an inherited disorder characterized by a triad of signs--mental retardation, seizures and adenoma sebaceum. The hamartomas that commonly affect multiple organ systems can be seen on plain film radiography. Computed tomography and ultr ... Link to item Cite

Peritoneal lymphomatosis.

Journal Article Am Fam Physician · October 1989 Link to item Cite

Desmoplastic fibroma.

Journal Article Am Fam Physician · August 1989 This benign bone tumor is locally invasive and has a high rate of recurrence. Three-quarters of cases present before age 30. The characteristic plain film finding is a centrally located lytic lesion, usually in the metaphysis or metadiaphyseal region of a ... Link to item Cite

Treatment modalities in Guillain-Barré syndrome.

Journal Article Hosp Pract (Off Ed) · March 15, 1987 Link to item Cite

Anorexia nervosa--thinness as illness.

Journal Article Postgrad Med · October 1983 Anorexia nervosa appears to be on the rise, perhaps in part due to the cultural ideal of a thin figure. The anorectic is typically a highly motivated, over-compliant adolescent girl or young woman who has had problems with self-image and social interaction ... Full text Link to item Cite