Scholars@Duke
Hilliard Foster Seigler

Hilliard Foster Seigler

Professor of Surgery
Surgical Oncology
seigl001@mc.duke.edu
Box 3966 Med Ctr, Durham, NC 27710
Room 469 Seeley Mudd Bldg, Durham, NC 27710

Selected Publications

A Historical Cohort in Kidney Transplantation: 55-Year Follow-Up of 72 HLA-Identical, Donor-Recipient Pairs.

Journal Article J Clin Med · November 24, 2021 The impact of HLA matching on graft survival has been well characterized in renal transplantation, with a higher degree of matching associated with superior graft survival. Additionally, living donor grafts are known to confer superior survival compared to ... Full text Link to item Cite

Overall Survival Improved for Contemporary Patients with Melanoma

Conference ANNALS OF SURGICAL ONCOLOGY · February 1, 2019 Link to item Cite

Efficacy of repeat sentinel lymph node biopsy in patients who develop recurrent melanoma.

Journal Article J Am Coll Surg · April 2014 BACKGROUND: Even after negative sentinel lymph node biopsy (SLNB) for primary melanoma, patients who develop in-transit (IT) melanoma or local recurrences (LR) can have subclinical regional lymph node involvement. STUDY DESIGN: A prospective database ident ... Full text Link to item Cite

Surgical training programs continue to evolve

Journal Article Journal of Surgical Radiology · December 21, 2012 Cite

Current trends in regional therapy for melanoma: lessons learned from 225 regional chemotherapy treatments between 1995 and 2010 at a single institution.

Journal Article J Am Coll Surg · August 2011 BACKGROUND: Hyperthermic isolated limb perfusion (HILP) and isolated limb infusion (ILI) are used to manage advanced extremity melanoma, but no consensus exists as to which treatment is preferable and how to monitor patients post-treatment. STUDY DESIGN: U ... Full text Link to item Cite

Does protected research time during general surgery training contribute to graduates' career choice?

Journal Article Am Surg · July 2011 A number of general surgery training programs offer a dedicated research experience during the training period. There is much debate over the importance of these experiences with the added constraints placed on training surgeons including length of trainin ... Link to item Cite

Potential Benefit of Radiation Therapy in Resectable Anorectal Melanoma

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Pediatric melanoma: a single-institution experience of 150 patients.

Journal Article J Pediatr Surg · August 2009 PURPOSE: Differentiating pigmented skin lesions from malignant melanoma in the pediatric population has been a challenge. Despite guidelines describing clinical features and histopathologic criteria to distinguish these lesions, misdiagnoses still occur. W ... Full text Link to item Cite

A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US.

Journal Article J Am Coll Surg · May 2009 BACKGROUND: Isolated limb infusion (ILI) is a minimally invasive approach for treating in-transit extremity melanoma, with only two US single-center studies reported. Establishing response and toxicity to ILI as compared with hyperthermic isolated limb per ... Full text Link to item Cite

Isolated limb infusion for in-transit malignant melanoma of the extremity: a well-tolerated but less effective alternative to hyperthermic isolated limb perfusion.

Journal Article Ann Surg Oncol · August 2008 BACKGROUND: Isolated limb infusion (ILI) is a recently described minimally invasive technique developed in Australia for delivering regional chemotherapy. This study examined the efficacy and toxicity of ILI, compared to hyperthermic isolated limb perfusio ... Full text Link to item Cite

Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity.

Journal Article Blood · December 15, 2007 The process of dendritic cell (DC) maturation, critical for effective DC-based immunotherapy, also alters the proteasome such that peptides presented in the context of HLA class I are generated not by the constitutive proteasome, but by the immunoproteasom ... Full text Link to item Cite

Improved survival with pulmonary metastasectomy: an analysis of 1720 patients with pulmonary metastatic melanoma.

Journal Article J Thorac Cardiovasc Surg · January 2007 OBJECTIVES: The outcomes of patients with metastatic melanoma are poor. Although prognostic models have been developed to predict the occurrence of pulmonary metastasis from cutaneous melanoma, few data exist to define the outcomes of these patients once m ... Full text Link to item Cite

The Kraske procedure: a critical analysis of a surgical approach for mid-rectal lesions.

Journal Article J Surg Oncol · September 1, 2006 BACKGROUND AND OBJECTIVES: To analyze the Kraske procedure as an approach to mid-rectal disease. METHODS: Twenty-two patients underwent a Kraske procedure at either Duke University Medical Center, the Durham Veterans Administration Medical Center, or the D ... Full text Link to item Cite

Melanoma of the ear: treatment and survival probabilities based on 199 patients.

Journal Article Ann Plast Surg · July 2006 BACKGROUND: In 2005, it is now estimated that one in 62 Americans have a lifetime risk of developing invasive melanoma. Melanoma of the ear accounts for 1% of all cases of melanoma and 14.5% of all head and neck melanomas. With this increase in incidence, ... Full text Link to item Cite

Histopathologic characteristics, recurrence patterns, and survival of 129 patients with desmoplastic melanoma.

Journal Article Ann Surg Oncol · May 2006 BACKGROUND: Desmoplastic melanoma (DM) has been associated with higher local recurrence rates than other types of cutaneous melanoma. Current controversies regarding locoregional treatment strategies warrant further investigation. METHODS: Retrospective re ... Full text Link to item Cite

Pathologic nodal status predicts disease-free survival after neoadjuvant chemoradiation for gastroesophageal junction carcinoma.

Journal Article Ann Surg Oncol · March 2006 BACKGROUND: The incidence of carcinoma of the gastroesophageal junction (GEJ) is rapidly increasing, and the prognosis remains poor. We examined outcomes in patients who received neoadjuvant chemoradiation for GEJ tumors to identify factors that predict di ... Full text Link to item Cite

Melanoma, a tumor based on a mutant stem cell?

Journal Article J Invest Dermatol · January 2006 Stem cells play a critical role in normal tissue maintenance, and mutations in these stem cells may give rise to cancer. We hypothesize that melanoma develops from a mutated stem cell and therefore residual stem cell characteristics should be able to be id ... Full text Link to item Cite

Brain metastases from malignant melanoma

Journal Article · December 1, 2005 Full text Cite

Predictors of outcome after hyperthermic isolated limb perfusion: role of tumor response.

Journal Article Arch Surg · November 2005 HYPOTHESIS: Analysis of multiple clinical and pathological factors in patients undergoing therapeutic hyperthermic isolated limb perfusion for extremity melanoma can identify variables with prognostic significance. DESIGN: Retrospective review of a prospec ... Full text Link to item Cite

Melanoma arising in a skin graft.

Journal Article Ann Plast Surg · January 2005 Cutaneous melanoma remains an ongoing public health threat, and the cornerstone of management continues to be early diagnosis and treatment. Unfortunately, primary melanomas may have atypical presentations, making early diagnosis difficult and causing sign ... Full text Link to item Cite

Mucosal melanoma.

Journal Article J Surg Oncol · July 1, 2004 Full text Link to item Cite

A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2004 PURPOSE: Eniluracil, an effective inactivator of dihydropyrimidine dehydrogenase, allows for oral dosing of 5-fluorouracil (5-FU), which avoids the morbidity of continuous infusion 5-FU. We addressed the safety of oral eniluracil and 5-FU combined with pre ... Full text Link to item Cite

Immunotherapy of surgical malignancies.

Journal Article Curr Probl Surg · January 2004 Full text Link to item Cite

Thin melanomas: predictive lethal characteristics from a 30-year clinical experience.

Journal Article Ann Surg · October 2003 OBJECTIVE: To guide treatment and clinical follow-up by defining the natural history of thin melanomas and identifying negative prognostic characteristics that may delineate high-risk patients. SUMMARY BACKGROUND DATA: In following > 10,000 patients with c ... Full text Link to item Cite

Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism.

Journal Article J Surg Oncol · February 2003 Featured Publication The rare finding of heterotopic ossification in a case of primary rectal adenocarcinoma is described along with a review of the literature. Immunohistochemistry for a bone morphogenic protein (BMP-2) and fibroblast growth factor (FGF-2), both of which indu ... Full text Link to item Cite

Invited critique

Journal Article Archives of Surgery · January 1, 2003 Cite

Combined hardening of composite materials based on aluminum

Journal Article Materials Science · November 1, 2002 Full text Cite

The long-term clinical course of patients with cutaneous melanoma.

Journal Article Cancer · September 15, 2002 Featured Publication BACKGROUND: The clinical course of cutaneous melanoma is associated with pathologic and clinical factors, such as thickness, ulceration, and location of tumor and gender of the patient. The authors used a parametric survival model that incorporated a cured ... Full text Link to item Cite

Screen and identification of proteins interacting with ADAM19 cytoplasmic tail.

Journal Article Mol Biol Rep · September 2002 ADAM family plays important roles in neurogenesis. The cytoplasmic tail of ADAM19 (ADAM19-CT) contains 193 residues. The presence of two putative SH3 ligand-binding sites suggests potential interactions with cytosolic proteins, which could be possibly link ... Full text Link to item Cite

Mutations of the BRAF gene in human cancer.

Journal Article Nature · June 27, 2002 Featured Publication Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis si ... Full text Link to item Cite

Long-term survival in 2,505 patients with melanoma with regional lymph node metastasis.

Journal Article Ann Surg · June 2002 Featured Publication OBJECTIVE: To examine the long-term outcomes of patients with melanoma metastatic to regional lymph nodes. SUMMARY BACKGROUND DATA: Regional lymph node metastasis is a major determinant of outcome for patients with melanoma, and the presence of regional ly ... Full text Link to item Cite

Poor outcome and quality of life in female patients undergoing secondary surgery for recurrent peptic ulcer disease.

Journal Article J Gastrointest Surg · 2002 Featured Publication Secondary peptic ulcer surgery is uncommon given the success of a wide variety of medical therapies, plus the good outcome expected after primary peptic ulcer surgery. Early reports of secondary peptic ulcer surgery in the 1950s and 1960s suggested good lo ... Full text Link to item Cite

Complete response to neoadjuvant chemoradiation for rectal cancer does not influence survival.

Journal Article Ann Surg Oncol · December 2001 BACKGROUND: Up to 30% of patients with locally advanced rectal cancer have a complete clinical or pathologic response to neoadjuvant chemoradiation. This study analyzes complete clinical and pathologic responders among a large group of rectal cancer patien ... Full text Link to item Cite

Primary chondroid melanoma.

Journal Article J Cutan Pathol · October 2001 BACKGROUND: Malignant melanoma is notorious for the wide range of histologic patterns it can assume, among the least frequent of which is chondroid melamona. METHODS: Two cases of primary chondroid melanoma of the distal lower extremity were studied. Tissu ... Full text Link to item Cite

Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells.

Journal Article Cell Immunol · June 15, 2001 Recognition of melanoma antigens by HLA class-II-restricted CD4(+) T lymphocytes has been investigated. Two cytotoxic CD4(+) T cell lines were established by stimulating PBLs from a melanoma patient with either parental or IFN-gamma-transduced autologous t ... Full text Link to item Cite

Impact of core-needle breast biopsy on the surgical management of mammographic abnormalities.

Journal Article Ann Surg · June 2001 OBJECTIVE: To evaluate the accuracy of percutaneous, image-guided core-needle breast biopsy (CNBx) and to compare the surgical management of patients with breast cancer diagnosed by CNBx with patients diagnosed by surgical needle-localization biopsy (SNLBx ... Full text Link to item Cite

Neoadjuvant chemoradiation for rectal cancer: analysis of clinical outcomes from a 13-year institutional experience.

Journal Article Ann Surg · June 2001 OBJECTIVE: To examine clinical outcomes in patients receiving neoadjuvant chemoradiation for locally advanced rectal adenocarcinoma. SUMMARY BACKGROUND DATA: Preoperative radiation therapy, either alone or in combination with 5-fluorouracil-based chemother ... Full text Link to item Cite

Identification of higher risk thin melanomas should be based on Breslow depth not Clark level IV.

Journal Article Cancer · March 1, 2001 BACKGROUND: There is good prognostic correlation for the two microstaging systems, Breslow depth and Clark level, commonly used to stage melanomas. Many investigators have reported that Breslow depth is the superior microstaging method. Although Clark leve ... Link to item Cite

Using a continuous transformation of the Breslow thickness for prognosis in cutaneous melanoma.

Journal Article Am J Clin Pathol · February 2001 Although the Breslow thickness provides the most important histologic information for prognosis in cutaneous melanoma, controversies and uncertainty remain about how best to use thickness. It is unclear whether cut points should be used, or, if they are us ... Full text Link to item Cite

Validation of delayed sentinel lymph node mapping for melanoma.

Journal Article Cancer J · 2001 PURPOSE: Sentinel lymph node mapping using radiolabeled tracer and blue dye is widely accepted and applied for staging melanoma. Common practice involves injection of radiolabeled tracer on the morning of surgery. However, optimal timing of radiolabeled co ... Link to item Cite

A model for pretest probability of lymph node metastasis from cutaneous Melanoma.

Journal Article Am J Clin Pathol · December 2000 Although many statistical models have been developed to predict survival in cutaneous melanoma, few predict the end point of regional lymph node metastasis shortly after the diagnosis of melanoma. We used routine clinical and histologic data from 573 patie ... Full text Link to item Cite

Gastrointestinal carcinoids: characterization by site of origin and hormone production.

Journal Article Ann Surg · October 2000 OBJECTIVE: To describe a large series of patients with carcinoid tumors in terms of presenting symptoms, hormonal data, stage at diagnosis, pathologic features, and survival. SUMMARY BACKGROUND DATA: Published series have described significant prognostic f ... Full text Link to item Cite

Subungual melanoma. A review of 93 cases with identification of prognostic variables.

Journal Article Clin Orthop Relat Res · September 2000 From 1970 to 1996, 93 patients received diagnoses of subungual melanoma. Followup data were complete on all patients and reviewed with a median duration of followup of 5.2 years. This study identifies significant clinicopathologic variables that affect sur ... Link to item Cite

Positron emission tomography scanning in malignant melanoma.

Journal Article Cancer · September 1, 2000 BACKGROUND: Several recent studies have demonstrated the low yield of anatomically based computed tomography scans in evaluating Stage III (American Joint Committee on Cancer) patients with malignant melanoma. The purpose of this study was to investigate t ... Link to item Cite

Depression after successful treatment for nonsmall cell lung carcinoma.

Journal Article Cancer · September 1, 2000 BACKGROUND: There have been few studies of depression in nonsmall cell lung carcinoma (NSCLC) patients after successful treatment. The purpose of the study was to clarify the prevalence and the correlated factors of depression after surgery. METHODS: A str ... Full text Link to item Cite

Dendritic cells infected with a vaccinia vector carrying the human gp100 gene simultaneously present multiple specificities and elicit high-affinity T cells reactive to multiple epitopes and restricted by HLA-A2 and -A3.

Journal Article J Immunol · April 15, 2000 To investigate the ability of human dendritic cells (DC) to process and present multiple epitopes from the gp100 melanoma tumor-associated Ags (TAA), DC from melanoma patients expressing HLA-A2 and HLA-A3 were pulsed with gp100-derived peptides G9154, G920 ... Full text Link to item Cite

Analysis of prognosis and disease progression after local recurrence of melanoma.

Journal Article Cancer · March 1, 2000 BACKGROUND: Local recurrence of melanoma is associated with a grave prognosis. However, the characteristics and the mode of disease progression for patients with local recurrence have not been adequately addressed in the literature. METHODS: A retrospectiv ... Full text Link to item Cite

Murine dendritic cells transfected with human GP100 elicit both antigen-specific CD8(+) and CD4(+) T-cell responses and are more effective than DNA vaccines at generating anti-tumor immunity.

Journal Article Int J Cancer · November 12, 1999 Dendritic cells (DCs) are potent inducers of cytotoxic T lymphocytes (CTLs) when pulsed with an antigenic peptide or tumor lysate. In this report, we have used liposome-mediated gene transfer to examine the ability of plasmid DNA encoding the human melanom ... Full text Link to item Cite

Timing of sentinel lymph node mapping after lymphoscintigraphy.

Journal Article Surgery · August 1999 BACKGROUND: Sentinel lymph node (SLN) mapping is an effective technique for staging patients with melanoma. In an attempt to avoid reinjection of radiolabeled colloid and facilitate SLN mapping at the time of surgery, we examined whether residual radioacti ... Link to item Cite

MCA106 fibrosarcoma cells transduced with granulocyte/macrophage colony-stimulating factor are not superior to the wild-type cells in suppressing the growth of hepatic metastases.

Journal Article J Surg Oncol · May 1999 BACKGROUND AND OBJECTIVES: Vaccination with cytokine gene-modified tumor cells augments the immune response against established tumors and protects against tumor challenges. In this study, we investigated the vaccine potential of GM-CSF-transduced MCA106 f ... Full text Link to item Cite

Monitoring antitumour immune response during immunotherapy of cancer: why and how?

Journal Article BioDrugs · April 1999 Cancer remains one of the most important public health concerns facing us today. Despite recent therapeutic developments, conventional therapies have provided only limited success in the management of patients with advanced disease. The recent discovery of ... Full text Link to item Cite

Tumor cells cotransduced with B7.1 and gamma-IFN induce effective rejection of established parental tumor.

Journal Article Gene Ther · February 1999 Genetic modification of tumor cells with the gene for the B7.1 or with the genes for cytokines results in increased tumor cell immunogenicity. In the work reported here, immunization of naive animals with either B7.1 or gamma-IFN gene-modified MCA106 tumor ... Full text Link to item Cite

Melanoma of the gallbladder: a review of cases seen at Duke University Medical Center.

Journal Article Cancer · January 1, 1999 BACKGROUND: Both primary and metastatic melanoma of the gallbladder are rare. In cases involving isolated tumors of the gallbladder, there continues to be controversy regarding the establishment of primary status. Despite appropriate therapy, the diagnosis ... Link to item Cite

Malignant melanoma of the mucous membranes: a review of 119 cases.

Journal Article Ann Surg Oncol · December 1998 BACKGROUND: Melanomas arising from the mucous membranes lining the respiratory, digestive, and genitourinary tracts are rare. Women are more commonly affected than are men, mainly because there is no male counterpart for vulvovaginal lesions. The mainstay ... Full text Link to item Cite

Reporting fine-needle aspirates of breast: a survey of preferences among surgeons.

Journal Article Diagn Cytopathol · October 1998 BACKGROUND: The optimal format for reporting results of breast fine-needle aspiration cytology is controversial, with some experts favoring a five-category system and others recommending a four-category format. METHODS: A survey of 200 surgeons was perform ... Full text Link to item Cite

Mucosal melanoma of the female genitalia: a clinicopathologic study of forty-three cases at Duke University Medical Center.

Journal Article Surgery · July 1998 BACKGROUND: Mucosal melanoma of the female genitalia is a rare neoplasm. Only nine reports reviewing more than 40 patients have been published on this subject in the past 30 years. These lesions arise from melanocytes, which can be found within the mucosa ... Link to item Cite

Pulsing of dendritic cells with cell lysates from either B16 melanoma or MCA-106 fibrosarcoma yields equally effective vaccines against B16 tumors in mice.

Journal Article J Surg Oncol · June 1998 BACKGROUND AND OBJECTIVES: Dendritic cells (DC) pulsed in vitro with a variety of antigens have proved effective in producing specific antitumor effects in vivo. Experimental evidence from other laboratories has confirmed that shared antigens can be encoun ... Full text Link to item Cite

Human dendritic cells, pulsed with either melanoma tumor cell lysates or the gp100 peptide(280-288), induce pairs of T-cell cultures with similar phenotype and lytic activity.

Journal Article Cell Immunol · May 25, 1998 Dendritic cells (DCs) pulsed with unfractionated tumor cell lysates or defined tumor peptides provide potent vaccines which elicit strong antitumor immunity. In this study, we generated DCs from the 2-h adherent progenitor cells obtained from the periphera ... Full text Link to item Cite

Vaccination with dendritic cells inhibits the growth of hepatic metastases in B6 mice.

Journal Article Cell Immunol · April 10, 1998 Dendritic cells (DC) are specialized antigen-presenting cells that can activate naive and mature T-cells, induce cellular immunity, and stimulate strong antitumor reactions in vivo. This study was undertaken to examine the function of DC vaccines in suppre ... Full text Link to item Cite

Demographics, prognosis, and therapy in 702 patients with brain metastases from malignant melanoma.

Journal Article J Neurosurg · January 1998 UNLABELLED: Brain metastases are a common and devastating complication in patients with malignant melanoma. Therapeutic options for these patients are limited, and the prognosis is usually poor. OBJECT: A retrospective review of 6953 patients with melanoma ... Full text Link to item Cite

Primary malignant melanoma of the esophagus.

Journal Article J Surg Oncol · November 1997 A 48-year-old woman presented with a 6-month history of dysphagia, often associated with retrosternal chest pain. Upper endoscopy revealed an unusual pigmented lesion within the middle portion of the esophagus, and multiple biopsies were obtained. The hist ... Full text Link to item Cite

A Phase I clinical trial of immunotherapy with interferon-gamma gene-modified autologous melanoma cells: monitoring the humoral immune response.

Journal Article Cancer · August 1, 1997 BACKGROUND: Tumor cells transduced with cytokine genes provide immunogenic vaccines for cancer immunotherapy. METHODS: A Phase I clinical trial was conducted for the specific active immunization of melanoma patients with interferon-gamma (IFN-gamma) gene-m ... Full text Link to item Cite

Immunotherapeutic potential of tumor antigen-pulsed and unpulsed dendritic cells generated from murine bone marrow.

Journal Article Cell Immunol · July 10, 1997 Dendritic cells (DC) are highly efficient antigen-presenting cells able to capture, process, and present antigens to naive and primed T-cells. In this study, we have investigated the ability of DC, derived from murine bone marrow and pulsed with tumor cell ... Full text Link to item Cite

Generation of primary tumor-specific cytotoxic T lymphocytes from autologous and human lymphocyte antigen class I-matched allogeneic peripheral blood lymphocytes by B7 gene-modified melanoma cells.

Journal Article Cancer Res · April 15, 1997 Expression of B7.1 costimulatory molecules on tumor cells has been shown to elicit antitumor immunity in mice. In the present study, we have developed a human B7.1 retroviral vector system to effectively transduce human melanoma cell lines and investigated ... Link to item Cite

Eradication of melanoma pulmonary metastases by immunotherapy with tumor cells engineered to secrete interleukin-2 or gamma interferon.

Journal Article Cancer Gene Ther · 1997 This study was undertaken to investigate the effectiveness of interleukin-2 (IL-2) and gamma interferon (gammaIFN)-modified B16 melanoma cells in the immunotherapy of established melanoma pulmonary metastases. The genes for IL-2 and gammaIFN were introduce ... Link to item Cite

Recognition and lysis of human melanoma by a CD3+, CD4+, CD8- T-cell clone restricted by HLA-A2.

Journal Article Cell Immunol · August 25, 1996 The in vitro cytotoxic response to human melanoma is characterized by CD3+ CD8+ T-cells which recognize shared peptide antigens presented in the context of HLA class-I-encoded gene products. We report here studies of a CD3+, CD4+, CD8-, HLA-A2-restricted, ... Full text Link to item Cite

Effect of irradiation on cytokine production, MHC antigen expression, and vaccine potential of interleukin-2 and interferon-gamma gene-modified melanoma cells.

Journal Article Cell Immunol · August 1, 1996 Recent studies have shown that tumor cells transduced with interleukin-2 (IL-2) or interferon-gamma (IFN-gamma) genes stimulated a potent and specific antitumor immunity in experimental animals. For use as a human vaccine, tumor cells must be inactivated b ... Full text Link to item Cite

Letter to the Editor

Journal Article Annals of Surgery · July 1996 Full text Cite

Immunological memory induced by genetically transduced tumor cells.

Journal Article Ann Surg Oncol · May 1996 BACKGROUND: Recent studies have demonstrated the usefulness of gene-modified tumor cells for immunotherapy. Using the tumorigenic murine fibrosarcoma, MCA 106, we investigated the effects of localized interferon-gamma (IFNg) secretion on tumorigenicity and ... Full text Link to item Cite

Modulation of specific active immunization against murine melanoma using recombinant cytokines.

Journal Article Surg Oncol · 1996 Specific active immunization with tumour cells and IL-1beta or IL-2 was examined in a murine model. Mice were treated with irradiated B16 melanoma, IL-1beta or IL-2 only, or with B16 plus cytokines prior to i.v. challenge with viable B16. Lung metastases w ... Full text Link to item Cite

Pregnancy in association with malignant melanoma

Journal Article Clinical Consultations in Obstetrics and Gynecology · December 1, 1995 J.P. is a 35-year-old white female who presented in December 1988 with an irregular pigmented lesion on her right lower thigh and a palpable node in her right groin. Biopsy of the lesion showed an ulcerated, Clark Level 4. 2.7 mm malignant melanoma [Fig 1) ... Cite

Immunotherapy of Human Melanoma With Gene-Modified Tumor Cell Vaccines.

Journal Article Cancer Control · October 1995 The incidence of melanoma in the United States is increasing at a faster rate than that of any other cancer. The prognosis for metastatic disease is poor, and more effective treatments for disseminated disease are needed. Since melanoma is one of the more ... Full text Link to item Cite

Metastatic melanoma to the spine. Demographics, risk factors, and prognosis in 114 patients.

Journal Article Spine (Phila Pa 1976) · October 1, 1995 STUDY DESIGN: One-hundred-fourteen patients with metastatic melanoma of the spine were retrospectively reviewed. OBJECTIVE: The goal was to define the demographics, risk factors, and prognosis for this population. SUMMARY OF BACKGROUND DATA: The incidence ... Full text Link to item Cite

Preoperative radiation and chemotherapy in the treatment of adenocarcinoma of the rectum.

Journal Article Ann Surg · June 1995 OBJECTIVE: In this study, the impact of preoperative chemotherapy and radiation on the histopathology of a subgroup of patients with rectal adenocarcinoma was examined. As well, survival, disease-free survival and pelvic recurrence rates were examined, and ... Full text Link to item Cite

The orderly progression of melanoma nodal metastases.

Journal Article Ann Surg · December 1994 OBJECTIVE: The aim of this study was to determine the order of melanoma nodal metastases. SUMMARY BACKGROUND DATA: Most solid tumors are thought to demonstrate a random nodal metastatic pattern. The incidence of skip nodal metastases precluded the use of s ... Full text Link to item Cite

Transduction of human melanoma cells with interleukin-2 gene reduces tumorigenicity and enhances host antitumor immunity: a nude mouse model.

Journal Article Cell Immunol · November 1994 Human melanoma tumor cells were genetically modified in vitro by transferring the interleukin-2 (IL-2) gene via a retroviral vector into established or fresh tumor cells. In addition, human melanoma cells were transduced in vivo by the direct injection of ... Full text Link to item Cite

Transduction of human melanoma cells with the gamma interferon gene enhances cellular immunity.

Journal Article Cancer Gene Ther · September 1994 Human tumor cells transduced with the gamma interferon (gamma IFN) gene are currently used in specific active immunotherapy protocols to enhance the antitumor immune responses of cancer patients. This in vitro study was undertaken to examine the initial ev ... Link to item Cite

Malignant melanoma in children.

Journal Article Ann Surg Oncol · July 1994 BACKGROUND: Cutaneous melanoma is an uncommon malignancy in children and for this reason, there is little information available regarding the timing and patterns of recurrence in children with this disease. This study reviews the experience at a single ins ... Full text Link to item Cite

Melanoma of the foot.

Journal Article J Bone Joint Surg Am · June 1994 We performed a prospective study of the results of treatment of primary cutaneous melanoma of the foot in 282 patients to determine if there were any factors that could predict survival. These patients were part of a group of 1018 patients who had primary ... Full text Link to item Cite

Survival superiority of females with melanoma. A multivariate analysis of 6383 patients exploring the significance of gender in prognostic outcome.

Journal Article Arch Surg · March 1994 OBJECTIVE: To evaluate the effects of gender on prognostic outcome of patients with melanoma. DESIGN: Retrospective cohort study, including 20 years of follow-up. SETTING: Duke University Melanoma Clinic, Durham, NC, a referral center for patients with mel ... Full text Link to item Cite

Surgical management of regional lymph nodes in patients with melanoma. Experience with 4682 patients.

Journal Article Ann Surg · February 1994 OBJECTIVE: The purpose of this study was to evaluate a large number of patients with cutaneous melanoma who had or who were at risk for lymph node metastases to contribute to the understanding of the behavior of and appropriate management of draining nodes ... Full text Link to item Cite

Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy.

Journal Article Cancer Res · January 15, 1994 Topoisomerase I has been identified as an intracellular target of camptothecin, a plant alkaloid with anticancer activity. Various lines of evidence suggest that the sensitivity of cells to this drug is directly related to the topoisomerase I content. In h ... Link to item Cite

Survival superiority of females with melanoma

Journal Article Archives of Surgery · 1994 Cite

Cell surface reactive human monoclonal antibody directed to human melanoma-associated gangliosides.

Journal Article Melanoma Res · December 1993 An IgM human monoclonal antibody (human MAb) was generated by fusing lymph node cells isolated from a surgical specimen of malignant melanoma with the heteromyeloma cell line SHMD-33. The antibody, designated 7c11.e8, reacted with surface antigens on human ... Full text Link to item Cite

Skin melanoma. Cured fraction and survival time as functions of thickness, site, histologic type, age, and sex.

Journal Article Cancer · August 15, 1993 BACKGROUND: Previously, nonparametric or semiparametric methods have been used to determine the relationship of various prognostic covariates with survival of skin cancer. Unfortunately, these methods do not readily distinguish between factors that modulat ... Full text Link to item Cite

Randomized trial of high-dose chemotherapy with autologous bone marrow support as adjuvant therapy for high-risk, multi-node-positive malignant melanoma.

Journal Article J Natl Cancer Inst · July 7, 1993 BACKGROUND: Chemotherapy adjuvant to surgery in metastatic melanoma has been evaluated in only a few prospective randomized trials. In the treatment of metastatic melanoma, dacarbazine has response rates of 15%-25% and in several studies, when combined wit ... Full text Link to item Cite

Lentigo maligna melanoma of the head and neck.

Journal Article Laryngoscope · May 1993 Historically, lentigo maligna melanoma has been considered a "favorable" histological type of melanoma, and treatment by wide local excision was considered curative. A retrospective multivariate analysis of 143 head and neck patients with stage I lentigo m ... Full text Link to item Cite

Survival of patients with carcinoma of the esophagus treated with combined-modality therapy.

Journal Article J Thorac Cardiovasc Surg · April 1993 Since 1985, 229 cases of carcinoma of the esophagus have been considered for entry into a protocol with the use of preoperative chemotherapy and radiation therapy followed by surgical intervention as the primary element of treatment. One hundred sixty-five ... Link to item Cite

Multiple primary melanoma: incidence and risk factors in 283 patients.

Journal Article Surgery · March 1993 To identify patients with melanoma at risk for a second primary lesion and to assess the prognostic relevance of multiple primary lesions, 7816 patients treated for malignant melanoma have been reviewed. Two to nine primary lesions were identified in 283 p ... Link to item Cite

Epidural spinal metastases from malignant melanoma: Demographics, prognosis and treatment.

Journal Article Canadian Journal of Neurological Sciences · 1993 Cite

Prevention and early detection of melanoma: a surgeon's perspective.

Journal Article Semin Surg Oncol · 1993 Americans are clearly losing the battle against malignant melanoma. In 1930, it was estimated that one in 1,500 people would develop melanoma sometime during their lifetimes, but by the year 2000, one in 75 people in the United States will develop the dise ... Link to item Cite

Possibilities of immunotherapy and gene therapy for malignant melanoma.

Journal Article Semin Surg Oncol · 1993 Over the last decade, both immunotherapy and gene therapy have emerged as exciting new modalities in the treatment of malignant melanoma. The fact that many melanoma patients mount cellular and humoral responses against their tumors, and that melanomas exp ... Link to item Cite

Letter to the editor [5]

Journal Article Annals of Surgery · January 1, 1993 Cite

Relationship between disease-free interval and survival in patients with recurrent melanoma.

Journal Article Arch Surg · November 1992 A total of 2468 patients with recurrent melanoma were subdivided on the basis of disease-free interval: group 1 had recurrences within 1 year (n = 810), group 2 at years 1 to 3 (n = 1001), group 3 at years 3 to 5 (n = 363), group 4 at years 5 to 10 (n = 32 ... Full text Link to item Cite

The annual risk of melanoma progression. Implications for the concept of cure.

Journal Article Cancer · October 1, 1992 BACKGROUND: Melanoma may remain clinically dormant for years, and patients may have distant metastatic disease decades after the initial diagnosis is made. Because of this potential for late recurrence, the concept of "cure" for melanoma is not particularl ... Full text Link to item Cite

Thin malignant melanomas of the head and neck.

Journal Article Laryngoscope · August 1992 Historically, Breslow classified thin melanomas as invasive lesions less than 0.76 mm in depth with rare instances of recurrence and mortality. From 1970 to 1990, 87 patients with thin head and neck melanoma were treated at Duke Medical Center. A computer- ... Full text Link to item Cite

Human melanoma-mediated inhibition of autologous CD4+ helper tumor-infiltrating lymphocyte growth in vitro.

Journal Article Cancer · April 1, 1992 Tumor-infiltrating lymphocytes (TIL) were isolated from a human melanoma metastatic to the abdomen. The TIL were 99% CD3+ and 99% CD4+ and CD8-. They were dependent on interleukin-2 (IL-2) for growth, as measured in a thymidine uptake assay, and were not c ... Full text Link to item Cite

Inhibition of the growth of human melanoma metastases in nude mice by melanoma-specific murine monoclonal antibody.

Journal Article Surg Oncol · April 1992 The administration of anti-melanoma murine monoclonal antibody (MAB) 16.C8 (IgG2a) to nude mice bearing established human melanoma lung or liver metastases resulted in a significant inhibition of tumour growth. A total dose of 2 mg of affinity purified 16. ... Full text Link to item Cite

Analysis of 945 cases of pulmonary metastatic melanoma.

Journal Article J Thorac Cardiovasc Surg · April 1992 From 1970 to 1990, 7564 patients with melanoma were seen at Duke University Cancer Center. Complete follow-up data were available in all patients. The estimated probability of a pulmonary metastasis developing 5, 10, or 20 years after initial diagnosis was ... Link to item Cite

Human xenograft-nude mouse model of adoptive immunotherapy with human melanoma-specific cytotoxic T-cells.

Journal Article Cancer Res · January 15, 1992 We investigated the efficacy of human melanoma-specific cytotoxic T-cells (CTLs) in treating experimental human melanoma metastases in a nude mouse model of adoptive immunotherapy. Hepatic metastases were generated by the intrasplenic injection of 1.5 x 10 ... Link to item Cite

Prospects for cellular immunotherapy for metastatic melanoma.

Journal Article Ann Plast Surg · January 1992 Systemic therapy for metastatic malignant melanoma has been disappointing. The search for alternate therapeutic methods includes investigation of the interaction between melanoma and the human immune system. A cellular immune response to melanoma has been ... Full text Link to item Cite

Immunotherapy for malignant melanoma with a tumor cell vaccine.

Journal Article Ann Plast Surg · January 1992 Specific active immunotherapy for melanoma has been administered to several thousand patients since 1972, using an irradiated whole-cell preparation. A humoral response to vaccination can be demonstrated in a large percentage of patients. This response inc ... Full text Link to item Cite

Generation of human IgG, IgA, and IgM anti-melanoma monoclonal antibodies utilizing lymphocytes of an actively immunized melanoma patient.

Journal Article Hum Antibodies Hybridomas · January 1992 Active specific immunotherapy with irradiated allogeneic melanoma cells has been shown to enhance the humoral immune response in melanoma patients. An increased titer of melanoma-binding antibodies was demonstrated in sera of immunized patients. Lymph node ... Link to item Cite

Malignant melanoma and pregnancy.

Journal Article Ann Plast Surg · January 1992 Among 100 patients diagnosed with melanoma during pregnancy and followed a mean of 6.8 years, when compared with a nonpregnant female population, there was a significantly shorter disease-free interval for the pregnant group. Median disease-free intervals ... Full text Link to item Cite

Anorectal melanoma: clinical characteristics and the role of abdominoperineal resection.

Journal Article Ann Plast Surg · January 1992 Twenty-four patients with primary anorectal melanoma diagnosed since 1974 have been retrospectively studied. The most common presenting symptom was rectal bleeding, typically misdiagnosed as hemorrhoids. Progressive disease most commonly presented as a lar ... Full text Link to item Cite

"Thin" malignant melanoma: risk factors and clinical management.

Journal Article Ann Plast Surg · January 1992 Thin melanomas can metastasize and can be lethal. Six hundred eighty-one patients with melanomas less than 0.76 mm thick have been evaluated, and are reviewed in this study and discussed in the context of a literature review. Among those referred without m ... Full text Link to item Cite

Recurrent malignant melanoma: the identification of prognostic factors to predict survival.

Journal Article Ann Plast Surg · January 1992 The prognostic factors for stage 1, 2 melanoma have been elucidated. Tumor thickness, ulceration of the primary melanoma, and perhaps, primary site may be used to predict the percentage of patients with regional nodal disease or systemic metastases and the ... Full text Link to item Cite

Therapeutic and prognostic considerations of head and neck melanoma.

Journal Article Ann Plast Surg · January 1992 Therapeutic considerations are discussed based on recurrence and survival statistics of 900 patients treated at Duke University Medical Center (Durham, NC). Approximately one-third of all patients developed recurrence. Factors affecting recurrence include ... Full text Link to item Cite

DNA ploidy of malignant melanoma determined by image cytometry of fresh frozen and paraffin-embedded tissue.

Journal Article J Cutan Pathol · December 1991 Image analysis of DNA content was performed from single nuclei of melanoma monolayer imprints made from fresh frozen tissue of 14 patients with primary malignant melanoma and 16 patients with local recurrences at the incision site and local or distant meta ... Full text Link to item Cite

Malignant melanoma in black Americans. A trend toward improved survival.

Journal Article Arch Surg · November 1991 A search of patients seen at the Duke University Melanoma Clinic (Durham, NC) identified 79 black patients. Five- and 10-year survival was 35% and 26%, respectively. Patients presenting in the recent decade had less advanced disease, resulting in an improv ... Full text Link to item Cite

Role of surgical intervention in the management of intestinal metastases from malignant melanoma.

Journal Article Am J Surg · November 1991 Malignant melanoma is the most common metastatic lesion of the intestine. Surgical consultation is often sought when bowel metastases become symptomatic. To determine the role of surgical intervention in such cases, a database of 6,000 melanoma patients wa ... Full text Link to item Cite

Cell binding and tumor inhibiting functions of a new antihuman melanoma murine monoclonal antibody.

Journal Article Mol Biother · September 1991 Murine, antihuman melanoma cell monoclonal antibody (mAb) 16.C8 was generated by fusing the murine myeloma cell line P3X63/Ag8.653 with splenocytes from a nude mouse bearing a human melanoma xenograft, after reconstitution with splenocytes from syngeneic i ... Link to item Cite

Treatment of human melanoma hepatic metastases in nude mice with human cytotoxic T lymphocytes.

Journal Article Arch Surg · April 1991 We investigated the effects of human melanoma-specific cytotoxic T lymphocytes in treating experimental human melanoma hepatic metastases in a nude mouse model of adoptive immunotherapy. Hepatic metastases were generated by intrasplenic injection of 1.5 x ... Full text Link to item Cite

MHC-restricted recognition of autologous melanoma by tumor-specific cytotoxic T cells. Evidence for restriction by a dominant HLA-A allele.

Journal Article J Immunol · March 1, 1991 Autologous melanoma-specific CTL recognize a common tumor-associated Ag (TAA) in the context of HLA class I antigens. We have demonstrated that HLA-A2 can be a restricting Ag and, in T cell lines homozygous for HLA-A2, that CTL can be generated by stimulat ... Link to item Cite

The role of resection in the management of melanoma metastatic to the adrenal gland.

Journal Article Surgery · February 1991 Melanoma metastatic to the adrenal gland diagnosed before death was exceedingly rare before the development of computed tomographic (CT) scanning. The records of 28 patients with melanoma metastatic to the adrenal gland seen since 1975 were reviewed. Eight ... Link to item Cite

Experimental trials of immunotherapy for malignant melanoma.

Journal Article Semin Surg Oncol · 1991 Conventional treatment for metastatic melanoma consists of surgical resection, chemotherapy, and radiation therapy. New approaches toward treatment of this disease include the development of passive and active immunotherapeutic regimens. Malignant melanoma ... Full text Link to item Cite

The role of elective lymph node dissection in the management of patients with thick cutaneous melanoma.

Journal Article Cancer · December 15, 1990 A retrospective search of patients seen at the Duke Melanoma Clinic from 1970 to 1986 identified 308 clinically Stage I patients, with 4.0 to 10.0 mm cutaneous melanomas. Five-year and ten-year survival was 56% and 43%, respectively. Elective lymph node di ... Full text Link to item Cite

Acral melanoma: a review of 185 patients with identification of prognostic variables.

Journal Article J Surg Oncol · October 1990 One hundred eight-five patients with acral melanoma treated since 1972 were reviewed. These included 53 subungual lesions, 123 plantar lesions, and 9 palmar lesions. Eighty percent presented with stage I disease. Mean age was 57 years. Males outnumbered fe ... Full text Link to item Cite

Effects of hyperthermia and irradiation on the growth of mouse melanoma tumors following immunotherapy.

Journal Article J Surg Oncol · August 1990 Recent investigations suggest that adjuvant hyperthermia enhances the response of human malignant melanoma to ionizing radiation. A study was undertaken to explore the effect of radiation and hyperthermia on the responsiveness of melanoma following active ... Full text Link to item Cite

Implications of leukoregulin to autologous tumor-specific human T-cell populations.

Journal Article J Biol Response Mod · August 1990 Interactions between the cellular and humoral compartments of the human immune system are well documented. Leukoregulin (LR) is a hormone with the ability to upregulate the natural killer (NK) phenomenon by increasing target cell sensitivity to NK lymphocy ... Link to item Cite

Late recurrence of malignant melanoma. Analysis of 168 patients.

Journal Article Ann Surg · August 1990 Analysis of 7104 patients with melanoma seen at Duke University identified 168 who experienced their first recurrence 10 or more years after diagnosis, for an incidence of 2.4%. This included patients with all stages of disease. There was no sex, age, or p ... Full text Link to item Cite

Malignant melanoma arising during pregnancy. A study of 100 patients.

Journal Article Ann Surg · May 1990 Melanoma is often diagnosed in young adults, a significant proportion of whom are women of child-bearing age. The prognosis of women diagnosed with melanoma during a pregnancy continues to be debated. One hundred patients, ages 19 to 40 years, have been id ... Full text Link to item Cite

Generation of human autologous melanoma-specific cytotoxic T-cells using HLA-A2-matched allogeneic melanomas.

Journal Article Cancer Res · February 1, 1990 Autologous tumor-specific cytotoxic T-lymphocytes (CTLs), generated by repeated stimulation with autologous melanoma and expanded in interleukin 2, are major histocompatibility complex restricted. These CTLs recognize a common tumor-associated antigen in t ... Link to item Cite

Modulation of in vitro autologous melanoma-specific cytotoxic T-cell responses by phorbol dibutyrate and ionomycin.

Journal Article Cell Immunol · February 1990 Human melanoma-specific, HLA restricted, cytotoxic T-cell lines can be generated by in vitro stimulation and culturing of peripheral lymphocytes, or lymph node cells, with autologous or HLA-A region matched melanomas in the presence of a low concentration ... Full text Link to item Cite

Inhibition of the growth of human melanoma xenografts in nude mice by human tumor-specific cytotoxic T-cells.

Journal Article J Surg Oncol · February 1990 Melanoma-specific T-cells (CTLs) are specifically cytotoxic for autologous tumor, when assayed in vitro. To examine their effectiveness in vivo, we tested the ability of these human T-cells to inhibit growth of human melanoma xenografts by using a Winn ass ... Full text Link to item Cite

Free jejunal interposition graft for reconstruction of the esophagus.

Journal Article Head Neck · 1990 Forty-seven patients underwent pharyngoesophageal reconstruction using a free jejunal interposition graft (FJIG) at Duke University Medical Center from 1978 through 1987. There were 30 men and 17 women with ages ranging from 38 to 87 years old (mean age, 6 ... Full text Link to item Cite

Anorectal melanoma: clinical characteristics and results of surgical management in twenty-four patients.

Journal Article Surgery · January 1990 Twenty-four patients with primary anorectal melanoma diagnosed since 1974 have been studied retrospectively. There was a predominance of women (2.4:1): Mean age was 64 years. The most common initial symptom was rectal bleeding, typically misdiagnosed as he ... Link to item Cite

Hepatobiliary cystadenoma with mesenchymal stroma.

Journal Article Ann Surg · January 1990 In a detailed review of cystic hepatobiliary neoplasms, we identified a subset of 50 cases in which tumors were characterized by the presence of a mesenchymal cell layer interposed between an inner epithelial lining and an outer connective tissue layer. We ... Full text Link to item Cite

Renal transplantation in the American black.

Journal Article Transplant Proc · December 1989 Link to item Cite

Melanoma-specific cytotoxic T cells generated from peripheral blood lymphocytes. Implications of a renewable source of precursors for adoptive cellular immunotherapy.

Journal Article Ann Surg · August 1989 Cytotoxic T lymphocytes (CTL) specific for autologous human melanoma have been generated in vitro from peripheral blood lymphocytes (PBL) of five patients with resectable stage II malignant melanoma. The PBL were cultured with 5u/ml recombinant IL-2 and we ... Full text Link to item Cite

The role of HLA class I antigens in recognition of melanoma cells by tumor-specific cytotoxic T lymphocytes. Evidence for shared tumor antigens.

Journal Article J Immunol · May 1, 1989 CTL lines were established in vitro by stimulating patient lymphocytes with autologous melanoma cells in the presence of IL-2. Resulting CTL lines lysed autologous melanoma and failed to lyse several allogeneic melanomas or K562. The mechanism of target ce ... Link to item Cite

Juvenile malignant melanoma.

Journal Article Surg Gynecol Obstet · March 1989 Malignant melanoma in children and adolescents is a rare phenomenon. During a retrospective computer-aided chart review, 78 patients less than 20 years of age were identified who had the diagnosis of malignant melanoma. This accounted for 1.8 per cent of a ... Link to item Cite

Melanoma patient antibody responses to melanoma tumor-associated antigens defined by murine monoclonal antibodies.

Journal Article J Biol Response Mod · February 1989 Sera from melanoma patients undergoing immunization with three distinct immunogens were evaluated for development of IgG antibody specific for the melanoma tumor-associated antigens (TAAs) GD3 and 250-kd glycoprotein (high molecular weight; HMW). Of 99 pat ... Link to item Cite

Serological response of non-human primates to human melanoma disialoganglioside GD3.

Journal Article Cancer Immunol Immunother · 1989 The immunogenicity of the disialoganglioside, GD3, a melanoma-tumor-associated antigen, has been evaluated in non-human primates. Sera from four chimpanzees and two monkeys were evaluated for anti-GD3 antibody activity by solid-phase radioimmunoassay using ... Full text Link to item Cite

Stage II malignant melanoma: presentation of a prognostic model and an assessment of specific active immunotherapy in 1,273 patients.

Journal Article J Surg Oncol · November 1988 The ability to redefine risk factors and to predict prognosis in patients with malignant melanoma at the time they manifest nodal metastasis can be a benefit to the patient emotionally and to the physician therapeutically. A retrospective review of 1,273 p ... Full text Link to item Cite

Human cytotoxic T cells specific for autologous melanoma cells: successful generation from lymph node cells in seven consecutive cases.

Journal Article J Natl Cancer Inst · September 7, 1988 Human T-cell populations specifically cytotoxic for autologous melanoma cells have been successfully generated from lymph node cells obtained from seven consecutive patients. The lymph node cells were stimulated in vitro with autologous irradiated melanoma ... Full text Link to item Cite

Lethal "thin" malignant melanoma. Identifying patients at risk.

Journal Article Ann Surg · August 1988 Thin melanomas can metastasize and be lethal. The purpose of this review was to identify negative risk factors in patients with melanomas less than 0.76 mm thick. Six hundred and eighty-one (681) such patients are reviewed in this study. Of those referred ... Full text Link to item Cite

Autologous lymph node cell-derived tumor-specific cytotoxic T-cells for use in adoptive immunotherapy of human melanoma.

Journal Article Cancer · July 1, 1988 The in vitro development of tumor-specific cytotoxic T-cells from draining and tumor-involved lymph nodes obtained from melanoma patients were examined. Fresh draining or tumor-involved lymph node cells (LNC) demonstrate no significant cytotoxic activity a ... Full text Link to item Cite

Juvenile malignant melanoma of the head and neck.

Journal Article Laryngoscope · February 1988 Malignant melanoma of the head and neck is a potentially lethal disease and considered rare among juveniles. Treatment patterns have historically been dictated by experience with adults, however a paucity of data is available to determine the natural histo ... Full text Link to item Cite

Biliary cystadenoma with mesenchymal stroma: CT and angiographic appearance.

Journal Article J Comput Assist Tomogr · 1988 A case of malignant biliary cystadenoma with CT and angiographic findings is reported. Clinical presentation, possible origin, epidemiology, and differential diagnosis of biliary cystadenoma and cystadenocarcinoma are discussed. ... Full text Link to item Cite

DU-PAN-2 levels in serum and pancreatic ductal fluids of patients with benign and malignant pancreatic disease.

Journal Article Pancreas · 1988 Previous studies have shown that the DU-PAN-2 antigen is elevated in approximately 70% of serum samples obtained from pancreatic adenocarcinoma patients, and within the normal range (less than 400 U/ml) in 99% of normal subjects. In this study, the DU-PAN- ... Full text Link to item Cite

Human T cells specifically activated against autologous malignant melanoma.

Journal Article Arch Surg · December 1987 Lymphocytes from ten patients with melanoma were specifically stimulated in vitro with autologous melanoma cells and expanded in interleukin 2. Significant lysis of autologous melanoma cells was demonstrated in T cells derived from six of these patients. T ... Full text Link to item Cite

Positive relationship of clinical and serologic responses to vaccinia melanoma oncolysate.

Journal Article Arch Surg · December 1987 In this phase Ia/Ib trial, vaccinia melanoma oncolysate (VMO) is a virus-augmented melanoma cell membrane vaccine that has been shown to be safe and to stimulate the production of antimelanoma antibodies in high-risk melanoma patients treated in a surgical ... Full text Link to item Cite

Clinical and pharmacologic effects of high dose single agent busulfan with autologous bone marrow support in the treatment of solid tumors.

Journal Article Cancer Res · December 1, 1987 A Phase I-II clinical trial of high dose single agent busulfan (16-20 mg/kg) administered over a 4-day period was undertaken. Pharmacokinetic measurements reveal that steady state total plasma busulfan levels between 2 and 10 microM were achieved by the se ... Link to item Cite

Prognosis for recurrent stage I malignant melanoma.

Journal Article Arch Surg · November 1987 The outcome of patients with stage I malignant melanoma has been well assessed in terms of prognostic factors and their effect on survival; however, little is known of the recurrence patterns of cutaneous melanoma or the survival of these patients subseque ... Full text Link to item Cite

The prognostic significance of recall antigen testing in melanoma patients.

Journal Article Am J Med Sci · November 1987 A quantitative assessment of the long-term prognostic value and clinical usefulness of recall antigen reactions in patients with malignant melanoma is not available. The authors evaluated longitudinal observations of survival made in 846 patients over a 12 ... Full text Link to item Cite

Inflammatory breast carcinoma. Effective multimodal approach.

Journal Article Arch Surg · November 1987 Twenty-two patients with inflammatory breast carcinoma received preoperative chemotherapy consisting of weekly administration of cyclophosphamide, doxorubicin hydrochloride, fluorouracil, and vincristine sulfate for six weeks. Postoperative therapy consist ... Full text Link to item Cite

Absence of estrogen receptor in human melanoma as evaluated by a monoclonal antiestrogen receptor antibody.

Journal Article Arch Dermatol · June 1987 Controversy regarding the presence of estrogen receptor proteins in human melanomas persists despite extensive investigations on this subject. While apparent high-affinity binding has been observed using dextran-coated charcoal assays, several other charac ... Link to item Cite

Early results with combined modality therapy for carcinoma of the esophagus.

Journal Article Ann Surg · May 1987 Since January 1984, 74 patients (61 men, 13 women; age range: 43-76 years) with carcinoma of the esophagus were evaluated. Fifty-two patients had squamous cell carcinoma and 22 patients had adenocarcinoma. Sixty-three patients had preoperative chemotherapy ... Full text Link to item Cite

Immune response of chimpanzee to purified melanoma 250 kilodalton tumor-associated antigen.

Journal Article Cancer Immunol Immunother · 1987 Melanoma high molecular weight tumor-associated antigen (TAA), having a molecular weight of 250 kilodaltons (Kd), was purified from a crude cell membrane extract through a combination of lectin affinity, immunoadsorption, and high performance liquid molecu ... Full text Link to item Cite

Diagnosis of metastatic malignant melanoma by fine needle aspiration biopsy: a clinical and pathologic correlation of 298 cases.

Journal Article J Natl Cancer Inst · November 1986 Fine needle aspiration biopsies (FNABs) from 298 lesions in patients with suspected metastatic melanoma were studied. The results were correlated either with histopathologic diagnoses on resected lesions or with prolonged clinical follow-up. Of 165 maligna ... Link to item Cite

Investigative studies in the diagnosis and treatment of melanoma.

Journal Article Invest Radiol · July 1986 Patients with melanoma have prognostic indicators that can be accurately assessed using standard histopathologic techniques. First-order lymph node disease plays a significant role in determining both the prognosis of the patient and the therapeutic benefi ... Full text Link to item Cite

Pectoralis pyomyositis: an unusual cause of chest wall pain in a patient with diabetes mellitus and rheumatoid arthritis.

Journal Article J Rheumatol · April 1986 We describe a case of isolated pectoralis swelling and tenderness, without systemic signs of infection, in a North American adult with diabetes mellitus and rheumatoid arthritis. The etiology was discovered to be pyomyositis, usually thought to be a diseas ... Link to item Cite

HIGH-DOSE BUSULFAN (BU) WITH AUTOLOGOUS BONE-MARROW SUPPORT (ABMS) - A PHASE-I TRIAL

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1986 Link to item Cite

A Southeastern Cancer Study Group phase I/II trial with vaccinia melanoma oncolysates.

Journal Article Cancer · February 1, 1986 Vaccinia melanoma oncolysates (VMO) were tested in a Southeastern Cancer Study Group (SECSG) Phase I/II trial. Forty-eight patients with high-risk Stage I or pathologic Stage II disease were placed on study at six different dose levels and two different tr ... Full text Link to item Cite

Fine needle aspiration biopsy of metastatic melanoma. A morphologic analysis of 174 cases.

Journal Article Acta Cytol · 1986 The prognostic and therapeutic decisions in cases of metastatic melanoma depend upon the morphologic documentation of metastatic disease, which may rapidly and accurately be done by fine needle aspiration (FNA) biopsy of clinically suspicious lesions. The ... Link to item Cite

Monitoring the donor-specific response of renal transplant patients by needle biopsy and long-term culture of alloreactive T-cell clones

Journal Article Transplantation Proceedings · January 1, 1986 Analyses of infiltrates present in rejecting renal transplants have demonstrated a predominance of T-cells. Although these cells have generally had a short life span in vitro, techniques for long-term propagation of them have recently been developed. In an ... Cite

Pharyngoesophageal reconstruction using free jejunal interposition grafts.

Journal Article Arch Otolaryngol · November 1985 Forty patients underwent pharyngoesophageal reconstruction with a free jejunal interposition graft (FJIG). Three categories of disease were treated: (1) primary upper aerodigestive tract carcinomas, (2) recurrent carcinomas, and (3) benign pharyngoesophage ... Full text Link to item Cite

Carcinoma of the pancreas. Therapeutic efficacy as defined by a serodiagnostic test utilizing a monoclonal antibody.

Journal Article Ann Surg · October 1985 DU-PAN-2 is a high molecular weight glycoprotein defined by a murine monoclonal antibody elicited to a pancreatic ductal adenocarcinoma cell line. This monoclonal antibody recognizes an oncofetal antigen present on the surface of pancreatic tumor cells. Th ... Full text Link to item Cite

Long-term clinical outcome of immediate reconstruction after mastectomy.

Journal Article Plast Reconstr Surg · September 1985 Immediate reconstruction of a breast removed for treatment of carcinoma can be accomplished without altering the cancer-ablative surgical procedure. The theoretical possibility that reconstruction might compromise the cure rate has tempered enthusiasm for ... Full text Link to item Cite

Immunodiagnosis of human malignancy.

Journal Article Ann Surg · April 1985 Definition of normal cell membrane antigens using immunologic techniques has permitted investigators to distinguish normal cells from malignant cells. Malignant cells express fetal antigens in concentrations different from normal mature cells. Mutant cells ... Full text Link to item Cite

Malignant melanoma and pregnancy.

Journal Article Cancer · March 15, 1985 Confusion exists concerning the influence of pregnancy on survival in patients with malignant melanoma. To evaluate this problem a retrospective computer-aided study was performed of women in the child-bearing years treated for Stage I cutaneous melanoma a ... Full text Link to item Cite

Expression of a melanoma-tumor-associated antigen as demonstrated by a monoclonal antibody (D6.1) in cytopathologic preparations of human tumor cells from effusions and needle aspirates.

Journal Article Anal Quant Cytol Histol · March 1985 Immunocytopathologic studies were performed on 79 fine needle aspiration biopsies (FNABs) and effusions from 13 melanomas and 57 other human neoplasms with the monoclonal antibody (MAb) D6.1 raised against a partially purified melanoma-tumor-associated ant ... Link to item Cite

Clinical studies of an oncofetal antigen (DU-PAN-2) detected by a monoclonal antibody to pancreatic adenocarcinoma

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1985 Cite

CLINICAL-STUDIES OF A PANCREATIC ONCOFETAL ANTIGEN (DU-PAN-2)

Journal Article DIGESTIVE DISEASES AND SCIENCES · January 1, 1985 Link to item Cite

Sex related survival differences in instances of melanoma.

Journal Article Surg Gynecol Obstet · October 1984 While data concerning melanoma survival differences between the sexes as they relate to anatomic site, stage and age is scattered throughout the literature, few single studies on one large population of patients with melanoma have specifically addressed al ... Link to item Cite

Detection of a pancreatic cancer-associated antigen (DU-PAN-2 antigen) in serum and ascites of patients with adenocarcinoma.

Journal Article Proc Natl Acad Sci U S A · August 1984 A competition radioimmunoassay was developed, utilizing a murine monoclonal antibody to human pancreatic adenocarcinoma cells. Immunoblotting of a standard antigen preparation from either serum or ascites fluid after electrophoresis in 1% agarose showed th ... Full text Link to item Cite

Radiologic, endoscopic, and surgical considerations of melanoma metastatic to the gastrointestinal tract.

Journal Article Surgery · June 1984 Malignant melanoma is the most common malignancy to metastasize to the gastrointestinal tract. In a retrospective computer-assisted data search of over 2500 patients with melanoma registered over the past 10 years, 110 patients have been identified to have ... Link to item Cite

[In vivo evaluation of cellular immunity in melanoma patients against melanoma].

Journal Article Nihon Geka Gakkai Zasshi · February 1984 Evaluation of cellular immunity against human melanoma was performed in an in vivo model using Balb/c nude mice bearing the human melanoma. Intraperitoneal injection of 1 X 10(7) melanoma cells produced peritonitis carcinomatosa which lead to death of the ... Link to item Cite

D6.1, a murine antimelanoma monoclonal antibody from congenitally athymic nude mice immunized with purified melanoma tumor-associated antigen.

Journal Article Hybridoma · 1984 An IgM monoclonal antibody, D6.1, has been obtained by fusion of P3 X 63Ag8.653 with spleen cells from congenitally athymic nu/nu mice immunized with partially purified human melanoma TAA bound to insolubilized lens culinaris lectin. The D6.1-defined antig ... Full text Link to item Cite

Computed tomography in the detection of abdominal metastases from malignant melanoma.

Journal Article Invest Radiol · 1984 Malignant melanoma is an unpredictable and often virulent cutaneous malignancy. Although computed tomography is the most sensitive method for detection of intrathoracic metastases, its value in the assessment of abdominal spread has not been fully defined. ... Full text Link to item Cite

ESTROGEN BINDING IN BREAST-CARCINOMA - REPLY

Journal Article ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE · January 1, 1984 Link to item Cite

Cutaneous melanoma of the head and neck. A review of 399 cases.

Journal Article Arch Otolaryngol · December 1983 A retrospective search of the Duke University Melanoma Clinic patients identified 399 cases with primary malignant melanoma located in the head and neck region. Ninety-five percent of the deaths in this series were from metastatic melanoma. Various clinica ... Full text Link to item Cite

Lymphoscintigraphy for malignant melanoma. Surgical considerations.

Journal Article Am Surg · December 1983 Lymphoscintigraphy using technetium-99m atimony sulfur colloid was performed in 22 patients with melanoma referred to Duke University Comprehensive Cancer Center in an attempt to identify patterns of regional lymphatic drainage. Scans from six patients rev ... Link to item Cite

Efficacy of elective lymph node dissection in patients with intermediate thickness primary melanoma.

Journal Article Ann Surg · September 1983 One of the most controversial areas in the management of malignant melanoma concerns the efficacy of prophylactic lymph node dissection. During a retrospective computer-aided data review of over 3000 melanoma patients referred to the Duke University Cancer ... Full text Link to item Cite

Immunodiagnosis of tumors in vivo using radiolabeled monoclonal antibody A2B5.

Journal Article J Surg Oncol · July 1983 Recently a murine monoclonal antibody (A2B5) has been described that reacts with a membrane associated GQ ganglioside common to peptide secreting normal cells and tumors. In vitro binding data demonstrated the presence of this ganglioside on neurons, adren ... Full text Link to item Cite

Functional and morphologic changes associated with insulinoma transplantation into diabetic rats.

Journal Article Am J Pathol · July 1983 Because of the technical difficulties encountered with human islet cell transplantation, alternatives toward supplying the juvenile diabetic with an endogenous insulin source are sought. With the use of a streptozotocin-induced diabetic rat model, it was f ... Link to item Cite

Solitary pulmonary metastases in high-risk melanoma patients: a prospective comparison of conventional and computed tomography.

Journal Article AJR Am J Roentgenol · July 1983 A prospective comparison of chest radiography, conventional tomography, and computed tomography (CT) in the detection or confirmation of solitary pulmonary nodules was made in 42 patients with high propensity for pulmonary metastases due to advanced local ... Full text Link to item Cite

Application of posterior neck dissection in treating malignant melanoma of the posterior scalp.

Journal Article Laryngoscope · June 1983 Utilization of a posterior neck dissection in the treatment of nine patients with malignant melanoma of the posterior scalp is presented. Seven of nine patients presented with metastatic disease present in the posterior neck after initial treatment elsewhe ... Full text Link to item Cite

Comparison of monoamine oxidase in golden hamster islets and insulinoma.

Journal Article Res Commun Chem Pathol Pharmacol · May 1983 We compared the properties of monoamine oxidase (MAO) in hamster islets and insulinomas. The tryptamine concentration at which the monoamine oxidase velocity was half maximal (Km) was higher in islets than insulinomas; the maximal velocity (Vmax) of monoam ... Link to item Cite

In Reply

Journal Article JAMA: The Journal of the American Medical Association · March 18, 1983 Full text Cite

Metastatic malignant melanoma with an unknown primary.

Journal Article Surg Gynecol Obstet · March 1983 Patients who are diagnosed initially as having metastatic melanoma with no known cutaneous, mucosal or ocular primary are a perplexing clinical problem. In the Duke University Melanoma Clinic, 124 patients have been identified as meeting the criteria of an ... Link to item Cite

Transplantation of rat insulinoma allografts with cyclosporin A.

Journal Article Surgery · February 1983 Cyclosporin A (CyA), an investigational immunosuppressive drug, was tested for its ability as a single agent to prevent rejection and maintain function of islet cell tumors transplanted across a major histocompatibility barrier. Lewis rats have previously ... Link to item Cite

CLINICAL-TRIAL OF DTIC, CCNU, BLEOMYCIN, AND VINCRISTINE (BOLD) CHEMOTHERAPY FOR METASTATIC MELANOMA

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1983 Link to item Cite

In vivo and in vitro binding of iodinated monoclonal antibody A2B5 to RIN insulinoma cells.

Journal Article Hybridoma · 1983 Monoclonal antibody A2B5 reacts with the cell surface of a series of amine precursor uptake decarboxylation (APUD) cells and their tumors in many vertebrate species including chicken, rat, mouse, and man. We have studied the in vivo and in vitro binding of ... Full text Link to item Cite

Malignant melanoma in black American and white American populations. A comparative review.

Journal Article JAMA · October 15, 1982 Malignant melanoma, a type of cancer that accounts for 1% to 3% of all malignant neoplasms in 20 times more frequent in the American white than black population. During a computer-aided retrospective chart review of more than 2,500 patients with melanoma b ... Link to item Cite

Immunoglobulin localization in the normal human mammary gland: variation with the menstrual cycle.

Journal Article Am J Pathol · June 1982 Differences in immunoglobulin localization (IgG, IgM, IgA) in benign versus malignant lesions of the human mammary gland have been previously demonstrated. The present investigation was undertaken to evaluate the influence of menstrual cycling on these imm ... Link to item Cite

Rationale for immediate reconstruction of the breast following modified radical mastectomy.

Journal Article Ann Plast Surg · January 1982 In 62 patients in whom modified radical mastectomy was accompanied by immediate breast reconstruction, the operative and pathologic findings are compared to the clinical results. Immediate reconstruction following modified radical mastectomy appears to off ... Full text Link to item Cite

Multiple assay characterization of murine monoclonal antimelanoma antibodies.

Journal Article Hybridoma · 1982 Selected murine monoclonal antimelanoma antibodies have been extensively evaluated using multiple radioimmunoassay methods, immunoprecipitation and immunohistochemistry. Use of this approach has permitted more complete definition of the specificity of thes ... Full text Link to item Cite

In vivo tumor localization using tumor-specific monkey xenoantibody, alloantibody, and murine monoclonal xenoantibody.

Journal Article Ann Surg · November 1981 Specific in vivo localization of antibodies reactive with human melanoma cell membrane tumor associated antigens (TAA) has been attempted using congenitally athymic nude mice bearing subcutaneous human melanoma tumor xenografts as the experimental model. I ... Full text Link to item Cite

Lymphoscintigraphy in malignant melanoma: 99mTc antimony sulfur colloid.

Journal Article AJR Am J Roentgenol · October 1981 Lymphoscintigrams were performed using technetium-99m antimony sulfur colloid in 21 patients with cutaneous malignant melanoma. Scintigraphic results were concordant with clinical prediction of lymph drainage in six of 11 patients with trunk melanoma, in f ... Full text Link to item Cite

[Basis for a specific-active immunotherapy in malignant melanoma].

Journal Article Schweiz Med Wochenschr · September 5, 1981 Since Morton demonstrated in 1968 that malignant melanoma is antigenic, many immunologists have taken an interest in this disease. A basis for specific active immunotherapy has been worked out at Duke University Medical Center, Durham, N.C. (USA). A female ... Link to item Cite

FUNCTION OF JEJUNAL AUTOTRANSPLANTS FOR REPLACEMENT OF THE CERVICAL ESOPHAGUS

Journal Article Investigative Radiology · September 1981 Full text Cite

SOLITARY PULMONARY METASTASIS IN ADVANCED LOCAL MALIGNANT MELANOMAS

Conference Investigative Radiology · September 1981 Full text Cite

Metastatic melanoma in the thorax: report of 130 patients.

Journal Article AJR Am J Roentgenol · August 1981 Early detection of metastatic melanoma has become more important as newer and more effective therapeutic regimens are used. Between 1970 and 1980, 1,600 patients were treated at one institution for malignant melanoma. Of these, 260 (16.3%) developed thorac ... Full text Link to item Cite

Immunoglobulin localization in benign and malignant lesions of the human mammary gland.

Journal Article Cancer · July 1, 1981 Using direct imunofluorescence, lesions from 266 human breast specimens were studied for the presence of IgA, IgM, or IgG localization. The lesions included benign elements from 66 subcutaneous mastectomy specimens in which the absence of simultaneous brea ... Full text Link to item Cite

Modified radical mastectomy with immediate reconstruction for carcinoma of the breast.

Journal Article Ann Surg · May 1981 Fifty patients undergoing immediate reconstruction of the breast following modified radical mastectomy for carcinoma were characterized by their clinical findings and the pathologic features of their tumors. Evidence of nipple--areolar involvement by tumor ... Full text Link to item Cite

Renal artery stenosis in children.

Journal Article J Pediatr Surg · February 1981 Because high blood pressure in children is rare and most of these patients are asymptomatic, many are overlooked until they present with a hypertensive crisis or irreparable damage. Most children with renal artery stenosis are asymptomatic and the hyperten ... Full text Link to item Cite

In vivo evaluation of cell mediated immunity against human melanoma.

Journal Article J Surg Oncol · 1981 Evaluation of cell mediated immunity against human melanoma target cells was performed in an in vivo model using human tumor xenografts growing in Balb/c athymic mice. Intraperitoneal inoculation of 1 x 10(7) human melanoma cells produced carcinomatosis wh ... Full text Link to item Cite

Central nervous system metastases in malignant melanoma.

Journal Article Neurosurgery · January 1981 In a series of 1341 patients with histologically proven malignant melanoma seen at Duke University Medical Center from 1968 to 1978, 107 patients developed central nervous system (CNS) metastases. These patients were evaluated on the basis of which factors ... Full text Link to item Cite

Cytochemistry of sex steroid receptors: a critique.

Journal Article Breast Cancer Res Treat · 1981 Full text Link to item Cite

Human melanoma growth in the peritoneal cavity of the athymic mouse--a model for in vivo study of cell-mediated immunity.

Journal Article J Surg Oncol · 1981 Intraperitoneal injections of 2 X 10(7) SH-Me cells (human metastatic melanoma cells)( to 20 Balb/c nu/nu mice (Group A) and 1 X 10(7) cells to 20 mice (Group B) were performed. All animals were studied clinicopathologically. Five animals in Group A were s ... Full text Link to item Cite

Influence of mouse hepatitis virus on the growth of human melanoma in the peritoneal cavity of the athymic mouse.

Journal Article J Surg Oncol · 1981 Mouse hepatitis virus (MHV) infection was found in 15 of 40 athymic mice (Balb/c nu/nu) used in an experimental model designed to study the effect of cell mediated immunity on target human melanoma cells growing in the peritoneal cavity. Most non-MHV-infec ... Full text Link to item Cite

CHARACTERIZATION OF MONOCLONAL-ANTIBODIES TOHUMAN PANCREATIC TUMOR-CELLS

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1981 Link to item Cite

RECURRENT GLOMERULONEPHRITIS-(GN) IN TRANSPLANTS

Journal Article KIDNEY INTERNATIONAL · January 1, 1981 Link to item Cite

FACTORS INFLUENCING SEX-DIFFERENCES IN SURVIVAL FOR PATIENTS WITH MELANOMA

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1981 Link to item Cite

DTIC, CCNU, bleomycin and vincristine (BOLD) in metastatic melanoma.

Journal Article Cancer · December 1, 1980 Treatment of 91 consecutive patients having metastatic, Stage IV melanoma who had not received any previous chemotherapy was begun between January 1977 and April 1978. The therapy included bleomycin (B) at 7.5 units subcutaneously in the first course and 1 ... Full text Link to item Cite

Sex steroid receptor analysis in human melanoma.

Journal Article Cancer · September 15, 1980 Melanomas from 20 patients were evaluated for estrogen and progesterone receptors. No restriction as to patient's age, sex, race, or menstrual status was made. Fifteen of the tumors were melanin producing. Of the 20 tumors examined, seven contained more th ... Full text Link to item Cite

Immunological consequences of transplanting rat insulinomas.

Journal Article Transplantation · July 1980 We investigated the genetics of transplanting a NEDH rat insulinoma in various donor-recipient combinations. The insulinoma survived indefinitely when it was transplanted in the NEDH strain. Mean survival times of 8.6 +/- 1.2 and 3.3 +/- 1.0 days were reco ... Full text Link to item Cite

Primary intracranial melanoma presenting as a suprasellar tumor.

Journal Article Neurosurgery · May 1980 A 37-year-old white woman presented with progressive visual loss in the right eye. The diagnostic evaluation suggested a tumor in the suprasellar area. At operation an isolated melanoma was found just superior to the sella turcica. No evidence of other int ... Full text Link to item Cite

Selection of patients for heterotopic implantation of the areola and nipple.

Journal Article Surg Gynecol Obstet · April 1980 In a prospective analysis of 291 specimens taken at mastectomy for carcinoma, 48 contained tumor in the nipple-areola complex. The characteristics of greater tumor size, higher frequency of lymph node involvement, midbreast tumor location and multifocality ... Link to item Cite

Characterization of melanoma cell membrane tumor-associated antigens using xenoserum, alloserum, and autoserum: I. immunofluorescence.

Journal Article J Surg Oncol · 1980 Xenoantiserum, alloantiserum, and autoantiserum prepared against human melanoma cells from cell lines maintained in tissue culture were evaluated by indirect immunofluorescence (ind IF) for their content of antibodies reactive with melanoma cell membrane t ... Full text Link to item Cite

Transplantation of insulinoma into the diabetic Syrian hamster.

Journal Article Ann Surg · January 1980 Syrian hamsters were rendered diabetic with intraperitoneal streptozotocin and were maintained in the diabetic state for a minimum of 14 days. A hamster islet cell tumor was transplanted subcutaneously with a prompt return of water intake (38 +/- 9.1 ml/da ... Full text Link to item Cite

Melanoma.

Journal Article Adv Surg · 1980 Link to item Cite

Postoperative function of "free" jejunal transplants for replacement of the cervical esophagus.

Journal Article Ann Surg · 1980 The postoperative function of "free" jejunal autotransplants for replacement of the pharyngoesophagus after palliative resection was evaluated in nine patients using clinical assessment, cinefluoroscopy, manometry, and electrical studies. After an initial ... Full text Link to item Cite

SPECIFIC ACTIVE IMMUNIZATION IN MELANOMA - PROGNOSTIC FACTORS

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1980 Link to item Cite

SPECIFIC ISOTOPIC SCAN LOCALIZATION OF HUMAN-MELANOMA USING IODINATED MONOSPECIFIC ANTIBODY

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1980 Link to item Cite

COMPARATIVE-ANALYSIS OF SEX STEROID BINDING IN HUMAN-MELANOMA

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1980 Link to item Cite

Cystosarcoma phylloides. A steroid receptor and ultrastructure analysis.

Journal Article Ann Surg · November 1979 Six cases of cystosarcoma phylloides were evaluated by ultrastructure and steroid receptor analysis. Electron microscopy of the lesions supported previous reports of a heterogeneous tumor consisting of pleomorphic mesenchyme and normal or proliferative epi ... Full text Link to item Cite

Alimentary tract complications after renal transplantation.

Journal Article Ann Surg · October 1979 A computer analysis of post renal transplantation gastrointestinal problems was performed to identify important associated clinical factors. Thirty-seven per cent of all transplant recipients developed one or more significant problems. Hemorrhage, nondiver ... Full text Link to item Cite

Monoamine oxidase and catechol-O-methyltransferase activity in hamster and rat insulinomas.

Journal Article Diabetologia · October 1979 Hamster and rat insulinomas were assayed for norepinephrine, dopamine and serotonin concentration and for monoamine oxidase and catechol-o-ethyltransferase (COMT) activity. The concentration of norepinephrine (mean 0.55 mumol/kg, range less than 0.20 to 2. ... Full text Link to item Cite

Specific active immunotherapy for melanoma.

Journal Article Ann Surg · September 1979 Full text Link to item Cite

Non-specific and specific active immunotherapy in a B16 murine melanoma system.

Journal Article J Surg Oncol · 1979 Conflicts amongst reports concerning the efficacy of both nonspecific and specific attempts at immunotherapy may be ascribed to different animal models utilizing tumors of different immunogenicity. We have selected the B16 mouse melanoma model as the examp ... Full text Link to item Cite

A phase II study of bleomycin, oncovin, lomustine and DTIC (BOLD) in stage IV metastatic melanoma

Journal Article Proceedings of the American Association for Cancer Research · 1979 Cite

PHASE-II STUDY OF BLEOMYCIN, ONCOVIN LOMUSTINE AND DTIC (BOLD) IN STAGE-IV METASTATIC MELANOMA

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1979 Link to item Cite

A phase II study of bleomycin, oncovin, lomustine and DTIC (BOLD) in stage IV metastatic melanoma

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1979 Cite

The spectrum of small bowel melanoma.

Journal Article Gastrointestinal Radiology · October 1, 1978 Twenty-one patients with documented secondary small bowel involvement by malignant melanoma are reviewed. Roentgen mainfestations are discussed and illustrated. A vigorous diagnostic approach emphasizing enteroclysis is described. Clinical awareness and ag ... Cite

The spectrum of small bowel melanoma.

Journal Article Gastrointest Radiol · October 1, 1978 Twenty-one patients with documented secondary small bowel involvement by malignant melanoma are reviewed. Roentgen mainfestations are discussed and illustrated. A vigorous diagnostic approach emphasizing enteroclysis is described. Clinical awareness and ag ... Full text Link to item Cite

Factors which have a significant effect on the survival of human skin grafts.

Journal Article Transplantation · September 1978 Survival of 436 ABO-compatible skin grafts exchanged in 97 Caucasian families was prolonged if donor and recipient were genotypically, as compared with phenotypically, HLA identical. Among skin grafts between haploidentical family members, a mismatch at th ... Full text Link to item Cite

Skeletal metastases of melanoma.

Journal Article J Bone Joint Surg Am · July 1978 Sixteen hundred and seventy-seven melanoma patients were treated at Duke University Medical Center from 1956 to 1976. Osseous metastases were more common than previously reported and occurred in 116 patients (6.9 per cent), most often in the axial skeleton ... Link to item Cite

Incidence of anatomical variants in renal vasculature in the presence of normal renal function.

Journal Article Ann Surg · July 1978 This report defines the incidence of variations in the renal vascular pedicle in a group of patients with normal renal function as determined by standard laboratory criteria. The study group consisted of 166 patients undergoing renal arteriography as poten ... Full text Link to item Cite

Solubilization and partial isolation of human melanoma tumor-associated antigens.

Journal Article J Natl Cancer Inst · July 1978 Human melanoma cell membrane tumor-associated antigens (TAA's) were solubilized in an active form by pronase digestion of either a fresh melanoma or cells from a melanoma cell line maintained in tissue culture. Upon elution from Sephadex G-200 column, TAA' ... Full text Link to item Cite

Cloacogenic carcinoma.

Journal Article Ann Surg · July 1978 Cloacogenic carcinoma is a rare tumor of the anorectal region originating from a persistant remnant of the cloacal membrane of the embryo. The tumor accounts for 2-3% of anorectal carcinomas and occurs more than twice as often in women. Most tumors present ... Full text Link to item Cite

Tumor membrane lymphocyte stimulation assay in patients with renal cell carcinoma.

Journal Article Cancer Res · May 1978 Peripheral blood lymphocytes from 15 patients with hypernephroma were stimulated with partially purified tumor plasma membranes to incorporate [3H]thymidine. Kidney tumor and normal kidney membranes were adjusted to antigenic equivalence as determined by t ... Link to item Cite

Gallbladder with ectopic gastric mucosa: ultrastructural analysis.

Journal Article Arch Pathol Lab Med · April 1978 The clinical and pathological findings of two patients with ectopic gastric mucosa within the gallbladder are studied and compared with the findings recorded in the literature. A contrast between incidental and symptomatic ectopia was noted in these cases. ... Link to item Cite

PARTIAL ISOLATION OF HUMAN MELANOMA TUMOR ASSOCIATED ANTIGENS

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1978 Link to item Cite

Invited commentary

Journal Article World Journal of Surgery · September 1, 1977 Full text Cite

Current management of melanoma.

Journal Article Ann Surg · July 1977 Full text Link to item Cite

Immunodiagnosis of melanoma using chimpanzee antihuman melanoma antiserum.

Journal Article Am J Clin Pathol · June 1977 Three cases of metastatic malignant lesions are presented. By conventional pathologic examination these lesions were diagnosed as undifferentiated carcinomas. They were studied using a chimpanzee antiserum specific for human melanoma-associated antigens. I ... Full text Link to item Cite

Long-term results with forty-five living related renal allograft recipients genotypically identical for HLA.

Journal Article Surgery · March 1977 During the past decade 45 living related renal allografts have been performed between siblings genotypically identical for HLA. In each case all available family members were serotyped and haplotype analysis was performed. Immunosuppressive therapy consist ... Link to item Cite

Enzymatic susceptibility and spontaneous release of human melanoma tumor-associated antigens.

Journal Article J Natl Cancer Inst · February 1977 A chimpanzee anti-human melanoma antiserum was used to study the enzymatic susceptibility and spontaneous release into tissue culture medium of human melanoma tumor-associated antigens (TAA). Limited proteolytic digestion of melanoma cells with trypsin or ... Full text Link to item Cite

Abnormalitieis of monocyte chemotaxis in patients with melanoma: effects of immunotherapy and tumor removal.

Journal Article J Natl Cancer Inst · January 1977 The chemotactic responsiveness of peripheral blood monocytes was studied before and after immunotherapy was administered to 56 patients with melanoma. Abnormal chemotaxis was found in 36 patients (64%) prior to treatment; this abnormality correlated with s ... Full text Link to item Cite

HLA-B7 associated tuberculin hyporesponsiveness in BCG treated melanoma patients.

Journal Article Monogr Allergy · 1977 Cutaneous responses to tuberculin and control antigens were measured in 24 HLA-B7 and 39 non-B7 patients before and 5-44 (average 10.5) weeks after BCG immunotherapy for malignant melanoma. Delayed tuberculin hypersensitivity increased after immunotherapy ... Link to item Cite

HLA-B7 associated tuberculin hyporesponsiveness in BCG treated patients

Journal Article American Review of Respiratory Disease · January 1, 1977 Cite

Apparent recurrence of progressive systemic sclerosis in a renal allograft.

Journal Article JAMA · August 30, 1976 A young woman with progressive systemic sclerosis (PSS) and renal failure who received a renal transplant from her mother suffered accelerated loss of allograft function in the absence of hyperacute rejection or severe hypertension. A biopsy specimen and p ... Link to item Cite

Cystic fibrosis in a black woman.

Journal Article JAMA · March 15, 1976 Link to item Cite

Renal transplantation between HL-A haploidentical donor-recipient pairs: functional and morphological evaluation.

Journal Article Surgery · March 1976 Fifty-nine recipients received renal allografts from an HL-A haploidentical family member. Immunogenicity of the incompatible haplotype was measured by skin grafts exchanged within each family when possible, and renal allograft recipients were assigned pro ... Link to item Cite

The use of non-human primates for production of antisera to human tumor-associated antigens.

Journal Article J Immunol Methods · 1976 High-titered antisera against human melanoma- and leukemia-associated antigens have been produced in non-human primates. The data from this and from other studies suggest that this model may prove a valuable source of highly specific antisera against a var ... Full text Link to item Cite

ENZYMATIC SUSCEPTIBILITY AND PARTIAL ISOLATION OF A MELANOMA ASSOCIATED ANTIGEN

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1976 Link to item Cite

Ileocolonic perforation. A complication following renal transplantation.

Journal Article Am J Roentgenol Radium Ther Nucl Med · November 1975 During the decade, February, 1965, through February, 1975, 248 patients underwent renal transplantation at the Duke Medical Center. One hundred twenty-five were living related recipients, while 123 were cadaveric recipients. Eleven patients developed ileoc ... Full text Link to item Cite

The incidence and management of pulmonary mycosis in renal allograft patients.

Journal Article Ann Surg · November 1975 A retrospective analysis of 193 renal transplant recipients yielded 15 patients who developed pulmonary mycosis posttransplantation and one case in which mycotic lung infection existed at the time of transplant surgery. Agent responsible for infection incl ... Full text Link to item Cite

Characterization of a chimpanzee anti-human melanoma antiserum.

Journal Article Cancer Res · August 1975 An antiserum to human melanoma has been produced in a chimpanzee by hyperimmunization with melanoma cells from a single donor. After absorption with the peripheral blood lymphocytes of the tumor donor, this antiserum is specifically cytotoxic to melanoma c ... Link to item Cite

Membranoproliferative glomerulonephritis. Progression from the pure form to the crescentic form with recurrence after transplantation.

Journal Article Am J Med · August 1975 Described are the clinical course and renal morphologic findings in a patient with membranoproliferative glomerulonephritis. intially, the patient had a pure form of membranoproliferative glomerulonephritis but after a 3 year course, it became crescentic. ... Full text Link to item Cite

Human melanoma and leukemia associated antigens difined by nonhuman primate antisera.

Journal Article Fed Proc · July 1975 The rationale of our approach to the detection and characterization of human leukemia and melanoma associated membrane antigens is to take advantage of the unique immunological recognition perspective of simians to huamn antigens. There are enough antigeni ... Link to item Cite

Management of recurrent melanoma of the extremity.

Journal Article Cancer · March 1975 Two forms of therapy employed for treatment of patients with recurrent melanoma limited to the extremity, and carried out during different intervals of time, are presented. Perfusion of the involved extremity with phenylalanine mustard has resulted in a 5- ... Full text Link to item Cite

Intralesional BCG, intravenous immune lymphocytes, and immunization with neuraminidase-treated tumor cells to manage melanoma; A clinical assessment.

Journal Article Plast Reconstr Surg · March 1975 An attempt was made to produce tumor immunity in 193 patients who had melanoma, 160 of whom had metastases and 33 of whom did not. Four stages of treatment are outlined. The patients whose disease was confined to the skin, subcutaneous tissues, and lymph n ... Link to item Cite

Immune competence of chimpanzees following thymectomy, splenectomy, and X irradiation

Journal Article Federation Proceedings · January 1, 1975 Cite

Management of recurrent melanoma of the extremity

Journal Article EXCERPTA MEDICA, ICS NO. 354 · 1975 Perfusion chemotherapy with Phenylalanine mustard was employed for treatment of patients with recurrent melanoma limited to the extremity, and has resulted in a 5 yr survival rate of 28% in 43 patients. The side effects of this form of treatment have been ... Cite

The use of BCG, adoptive transfer, and neuraminidase treated tumor cells in the management of melanoma

Journal Article BEHRING INST.MITT. · January 1, 1975 BCG immunization in 193 patients proved successful for the stimulation of delayed cutaneous hypersensitivity to PPD. The data tends to refute the hypothesis that BCG immunization brings about a general augmentation of delayed cutaneous hypersensitivity. Fu ... Cite

Management of recurrent melanoma of the extremity

Book · January 1, 1975 Perfusion chemotherapy with Phenylalanine mustard was employed for treatment of patients with recurrent melanoma limited to the extremity, and has resulted in a 5 yr survival rate of 28% in 43 patients. The side effects of this form of treatment have been ... Cite

Histocompatibility testing in chimpanzee families.

Journal Article Transplant Proc · June 1974 Link to item Cite

Immune responsiveness and immunotherapy in patients with metastatic melanoma

Journal Article BOL.ASOC.MED.P.R. · January 1, 1974 The results in 120 patients with melanoma that the authors studied and treated by immunotherapy are described. Serum immunoglobulin levels in patients with malignant melanoma revealed normal IgA and IgG levels and only infrequent IgM values were below the ... Cite

Hl-a typing, mixed leukocyte reactivity, and skin graft survival in a family with a recombinant at the hl-1 chromosomal region (Major transplantation region)

Journal Article Transplantation · January 1, 1973 The members of family Sch were studied by three different parameters: HL-A typing, mixed leukocyte reaction (MLR), and skin grafting. There were two HL-A-identical, mixed leukocyte reaction-identical siblings (MLR-S); two HL-A-identical, MLR-S- different s ... Full text Cite

The rehabilitation of renal allograft recipients.

Journal Article Transplant Proc · December 1972 Link to item Cite

Renal transplantation between HL-A identical donor-recipient pairs. Functional and morphological evaluation.

Journal Article J Clin Invest · December 1972 16 patients underwent renal transplantation from a sibling donor who was prospectively determined to be ABO compatible and HL-A identical with the recipient. Unidirectional mixed leukocyte reactions were performed; in each instance, lymphocyte stimulation ... Full text Link to item Cite

Characterization of chimpanzee leukocyte alloantisera.

Journal Article Transplant Proc · March 1972 Link to item Cite

Urologic morbidity in renal transplantation.

Journal Article South Med J · December 1971 Full text Link to item Cite

Selection of donors for kidney transplantation.

Journal Article Transplant Proc · June 1971 Link to item Cite

HL-A antigenic loss in malignant transformation.

Journal Article J Natl Cancer Inst · March 1971 Link to item Cite

Anomalous MLR responsiveness among siblings.

Journal Article Transplant Proc · March 1971 Link to item Cite

The immunogenicity of human HL-A haplotypesas measured by skin graft survival times and mixed leukocyte reactions.

Journal Article J Exp Med · March 1, 1971 The immunogenicity of the haplotypes in 30 families was measured by survival of skin grafts between selected paired family members. These families were genotyped for HL-A using 57 selected cytotoxic alloantisera defining HL-A 1-12 as well as other nondefin ... Full text Link to item Cite

Urologic complications in renal transplantation.

Journal Article Trans Am Assoc Genitourin Surg · 1971 Link to item Cite

Kidney transplantation using living donors.

Journal Article N C Med J · April 1970 Link to item Cite

Rejection of canine cardiac allografts.

Journal Article Am J Pathol · October 1968 Link to item Cite

Fractionation studies of human antisera containing leukocyte-agglutinating and cytotoxic isoantibodies

Journal Article Transplantation · January 1, 1967 Ten antisera from multiparous women or immunized volunteers containing isoantibodies to human leukocyte antigens were fractionated on Biogel P-300 polyacrylamide chromatographic columns. The fractions were tested by lymphocyte cytotoxicity and leukocyte ag ... Full text Cite