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Daniel John Sexton

Daniel John Sexton

Professor Emeritus of Medicine
Medicine, Infectious Diseases
sexto002@mc.duke.edu
Duke Box 102359, Durham, NC 27710
Hanes House--Trent Drive, Room 164, Durham, NC 27710

Selected Publications

Updated Genomic Epidemiologic Description of Candida (Candidozyma) auris, United States.

Journal Article Emerg Infect Dis · May 2026 The multidrug-resistant yeast Candida (Candidozyma) auris has caused several healthcare-associated outbreaks in the United States. We provide a genomic epidemiologic description of 1,535 C. auris isolates collected in the United States during 2013-2022. We ... Full text Link to item Cite

Pediatric CSF diversion procedures for treatment of hydrocephalus during the COVID-19 pandemic.

Journal Article J Neurosurg Pediatr · January 1, 2025 OBJECTIVE: Because there is not a link between COVID-19 and pediatric hydrocephalus, the COVID-19 pandemic should not have altered the incidence of pediatric hydrocephalus or the rate of CSF diversion procedures or shunt failure. Therefore, hydrocephalus-r ... Full text Link to item Cite

Rapid Environmental Contamination With Candida auris and Multidrug-Resistant Bacterial Pathogens Near Colonized Patients.

Journal Article Clin Infect Dis · May 15, 2024 BACKGROUND: Environmental contamination is suspected to play an important role in Candida auris transmission. Understanding speed and risks of contamination after room disinfection could inform environmental cleaning recommendations. METHODS: We conducted ... Full text Link to item Cite

Sporotrichosis Cluster in Domestic Cats and Veterinary Technician, Kansas, USA, 2022.

Journal Article Emerg Infect Dis · May 2024 We describe a feline sporotrichosis cluster and zoonotic transmission between one of the affected cats and a technician at a veterinary clinic in Kansas, USA. Increased awareness of sporotrichosis and the potential for zoonotic transmission could help vete ... Full text Link to item Cite

Harvesting the low-hanging fruit? Comparative assessment of intravenous to oral route antimicrobial conversion policy implementation.

Journal Article Infect Control Hosp Epidemiol · June 2023 Policies that promote conversion of antibiotics from intravenous to oral route administration are considered "low hanging fruit" for hospital antimicrobial stewardship programs. We developed a simple metric based on digestive days of therapy divided by tot ... Full text Link to item Cite

Therapeutic monoclonal antibodies with a focus on hereditary angioedema.

Journal Article Allergol Int · January 2023 Monoclonal antibodies (mAbs) have been shown to be effective and generally safe across a continually expanding list of therapeutic areas. We describe the advantages and limitations of mAbs as a therapeutic option compared with small molecules. Specifically ... Full text Link to item Cite

Impact of Antibiotic Stewardship Rounds in the Intensive Care Setting: A Prospective Cluster-Randomized Crossover Study.

Journal Article Clin Infect Dis · June 10, 2022 BACKGROUND: Few groups have formally studied the effect of dedicated antibiotic stewardship rounds (ASRs) on antibiotic use (AU) in intensive care units (ICUs). METHODS: We implemented weekly ASRs using a 2-arm, cluster-randomized, crossover study in 5 ICU ... Full text Link to item Cite

Impact of Oral Metronidazole, Vancomycin, and Fidaxomicin on Host Shedding and Environmental Contamination With Clostridioides difficile.

Journal Article Clin Infect Dis · March 1, 2022 BACKGROUND: Shedding of Clostridioides difficile spores from infected individuals contaminates the hospital environment and contributes to infection transmission. We assessed whether antibiotic selection affects C. difficile shedding and contamination of t ... Full text Link to item Cite

Effects of a Collaborative, Community Hospital Network for Antimicrobial Stewardship Program Implementation.

Journal Article Clin Infect Dis · November 2, 2021 BACKGROUND: Individual hospitals may lack expertise, data resources, and educational tools to support antimicrobial stewardship programs (ASP). METHODS: We established a collaborative, consultative network focused on hospital ASP implementation. Services i ... Full text Link to item Cite

Ehrlichiosis and anaplasmosis subcommittee report to the Tick-borne Disease Working Group.

Journal Article Ticks Tick Borne Dis · November 2021 Ehrlichioses and anaplasmosis have undergone dramatic increases in incidence, and the geographic ranges of their occurrence and vectors have also expanded. There is marked underreporting of these diseases owing to deficient physician awareness and knowledg ... Full text Link to item Cite

Tap Water Avoidance Decreases Rates of Hospital-onset Pulmonary Nontuberculous Mycobacteria.

Journal Article Clin Infect Dis · August 2, 2021 We analyzed the impact of a hospital tap water avoidance protocol on respiratory isolation of nontuberculous mycobacteria (NTM). After protocol implementation, hospital-onset episodes of respiratory NTM isolation on high-risk units decreased from 41.0 to 9 ... Full text Link to item Cite

Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases.

Journal Article J Intern Med · July 2021 BACKGROUND: Phosphorylcholine (PC) is an important pro-inflammatory damage-associated molecular pattern. Previous data have shown that natural IgM anti-PC protects against cardiovascular disease. We aimed to develop a monoclonal PC IgG antibody with anti-i ... Full text Link to item Cite

Assessing severe acute respiratory coronavirus virus 2 (SARS-CoV-2) preparedness in US community hospitals: A forgotten entity.

Journal Article Infect Control Hosp Epidemiol · May 2021 We performed a cross-sectional survey of infection preventionists in 60 US community hospitals between April 22 and May 8, 2020. Several differences in hospital preparedness for SARS-CoV-2 emerged with respect to personal protective equipment conservation ... Full text Link to item Cite

Invasive Mycobacterium abscessus Complex Infection After Cardiac Surgery: Epidemiology, Management, and Clinical Outcomes.

Journal Article Clin Infect Dis · April 8, 2021 BACKGROUND: We recently mitigated a clonal outbreak of hospital-acquired Mycobacterium abscessus complex (MABC), which included a large cluster of adult patients who developed invasive infection after exposure to heater-cooler units during cardiac surgery. ... Full text Link to item Cite

Microbial Assessment of Health Care-Associated Pathogens on Various Environmental Sites in Patient Rooms After Terminal Room Disinfection.

Journal Article Open Forum Infect Dis · February 2021 We examined the microbial burden on hospital room environmental sites after standard (quaternary ammonium [Quat]) or enhanced disinfection (quat/ultraviolet light [UV-C], bleach, or bleach/UV-C). An enhanced terminal room disinfection reduced the microbial ... Full text Link to item Cite

Effects of Patient Characteristics on Diagnostic Performance of Self-Collected Samples for SARS-CoV-2 Testing.

Journal Article Emerg Infect Dis · 2021 We evaluated the performance of self-collected anterior nasal swab (ANS) and saliva samples compared with healthcare worker-collected nasopharyngeal swab specimens used to test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We used the s ... Full text Link to item Cite

Universal masking in hospitals in the COVID-19 era: Is it time to consider shielding?

Journal Article Infect Control Hosp Epidemiol · September 2020 With concerns for presymptomatic transmission of COVID-19 and increasing burden of contact tracing and employee furloughs, several hospitals have supplemented pre-existing infection prevention measures with universal masking of all personnel in hospitals. ... Full text Link to item Cite

Comparative evaluation of the microbicidal activity of low-temperature sterilization technologies to steam sterilization.

Journal Article Infect Control Hosp Epidemiol · April 2020 OBJECTIVE: To compare the microbicidal activity of low-temperature sterilization technologies (vaporized hydrogen peroxide [VHP], ethylene oxide [ETO], and hydrogen peroxide gas plasma [HPGP]) to steam sterilization in the presence of salt and serum to sim ... Full text Link to item Cite

Long-term safety outcomes of prekallikrein (Fletcher factor) deficiency: A systematic literature review of case reports.

Journal Article Allergy Asthma Proc · January 17, 2020 Background: Hereditary prekallikrein (Fletcher factor) deficiency is a rare condition characterized by a prolonged activated partial thromboplastin time. Inhibitors of plasma kallikrein have recently been approved for prophylaxis of hereditary angioedema a ... Full text Link to item Cite

Practical Guidance for Clinical Microbiology Laboratories: A Comprehensive Update on the Problem of Blood Culture Contamination and a Discussion of Methods for Addressing the Problem.

Journal Article Clin Microbiol Rev · December 18, 2019 In this review, we present a comprehensive discussion of matters related to the problem of blood culture contamination. Issues addressed include the scope and magnitude of the problem, the bacteria most often recognized as contaminants, the impact of blood ... Full text Link to item Cite

Impact of FDA black box warning on fluoroquinolone and alternative antibiotic use in southeastern US hospitals.

Journal Article Infect Control Hosp Epidemiol · November 2019 We analyzed antibiotic use data from 29 southeastern US hospitals over a 5-year period to determine changes in antibiotic use after the fluoroquinolone US Food and Drug Administration (FDA) advisory update in 2016. Fluoroquinolone use declined both before ... Full text Link to item Cite

Feasibility of Core Antimicrobial Stewardship Interventions in Community Hospitals.

Journal Article JAMA Netw Open · August 2, 2019 IMPORTANCE: The feasibility of core Infectious Diseases Society of America-recommended antimicrobial stewardship interventions in community hospitals is unknown. OBJECTIVE: To determine the feasibility and results of implementing 2 core stewardship interve ... Full text Link to item Cite

Lanadelumab for the Prophylactic Treatment of Hereditary Angioedema with C1 Inhibitor Deficiency: A Review of Preclinical and Phase I Studies.

Journal Article BioDrugs · February 2019 Hereditary angioedema (HAE) with C1 esterase inhibitor (C1-INH) deficiency (C1-INH-HAE) is a rare disease characterized by diminished levels or dysfunctional activity of C1-INH, leading to dysregulated plasma kallikrein activity within the kallikrein-kinin ... Full text Link to item Cite

A prospective study of transmission of Multidrug-Resistant Organisms (MDROs) between environmental sites and hospitalized patients-the TransFER study.

Journal Article Infect Control Hosp Epidemiol · January 2019 OBJECTIVE: Hospital environmental surfaces are frequently contaminated by microorganisms. However, the causal mechanism of bacterial contamination of the environment as a source of transmission is still debated. This prospective study was performed to char ... Full text Link to item Cite

Endogenous bradykinin and B1-B5 during angiotensin-converting enzyme inhibitor-associated angioedema.

Journal Article J Allergy Clin Immunol · November 2018 Bradykinin concentrations and the ratio of bradykinin to its stable metabolite BK1–5 (RPPGF) were significantly increased in patients presenting with angiotensin-converting enzyme (ACE) inhibitor-associated angioedema compared to ACE inhibitor-treated cont ... Full text Link to item Cite

Antimicrobial activity of a continuous visible light disinfection system.

Journal Article Infect Control Hosp Epidemiol · October 2018 We evaluated the ability of high-intensity visible violet light with a peak output of 405 nm to kill epidemiologically important pathogens. The high irradiant light significantly reduced both vegetative bacteria and spores at some time points over a 72-hou ... Full text Link to item Cite

Hospital epidemiologists and the art of salesmanship.

Journal Article Infect Control Hosp Epidemiol · October 2018 Full text Link to item Cite

Enhanced disinfection leads to reduction of microbial contamination and a decrease in patient colonization and infection.

Journal Article Infect Control Hosp Epidemiol · September 2018 In this prospective study, we monitored 4 epidemiologically important pathogens (EIPs): methicillin-resistane Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), Clostridium difficile, and multidrug-resistant (MDR) Acinetobacter to assess ... Full text Link to item Cite

Performance of statistical process control methods for regional surgical site infection surveillance: a 10-year multicentre pilot study.

Journal Article BMJ Qual Saf · August 2018 BACKGROUND: Traditional strategies for surveillance of surgical site infections (SSI) have multiple limitations, including delayed and incomplete outbreak detection. Statistical process control (SPC) methods address these deficiencies by combining longitud ... Full text Link to item Cite

Effectiveness of targeted enhanced terminal room disinfection on hospital-wide acquisition and infection with multidrug-resistant organisms and Clostridium difficile: a secondary analysis of a multicentre cluster randomised controlled trial with crossover design (BETR Disinfection).

Journal Article Lancet Infect Dis · August 2018 BACKGROUND: The hospital environment is a source of pathogen transmission. The effect of enhanced disinfection strategies on the hospital-wide incidence of infection has not been investigated in a multicentre, randomised controlled trial. We aimed to asses ... Full text Link to item Cite

Feasibility and Value of Developing a Regional Antibiogram for Community Hospitals.

Journal Article Infect Control Hosp Epidemiol · June 2018 OBJECTIVETo determine the feasibility and value of developing a regional antibiogram for community hospitals.DESIGNMulticenter retrospective analysis of antibiograms.SETTING AND PARTICIPANTSA total of 20 community hospitals in central and eastern North Car ... Full text Link to item Cite

Denominator Matters in Estimating Antimicrobial Use: A Comparison of Days Present and Patient Days.

Journal Article Infect Control Hosp Epidemiol · May 2018 Patient days and days present were compared to directly measured person time to quantify how choice of different denominator metrics may affect antimicrobial use rates. Overall, days present were approximately one-third higher than patient days. This diffe ... Full text Link to item Cite

Implementation Lessons Learned From the Benefits of Enhanced Terminal Room (BETR) Disinfection Study: Process and Perceptions of Enhanced Disinfection with Ultraviolet Disinfection Devices.

Journal Article Infect Control Hosp Epidemiol · February 2018 OBJECTIVE To summarize and discuss logistic and administrative challenges we encountered during the Benefits of Enhanced Terminal Room (BETR) Disinfection Study and lessons learned that are pertinent to future utilization of ultraviolet (UV) disinfection d ... Full text Link to item Cite

Real-Time Surveillance of Influenza Morbidity: Tracking Intensive Care Unit Resource Utilization.

Journal Article Ann Am Thorac Soc · December 2017 RATIONALE: Existing real-time surveillance of influenza morbidity, based primarily on time-trended U.S. hospitalization and death data, is inadequate. These surveillance methods do not accurately predict hospital resource requirements or sufficiently captu ... Full text Link to item Cite

Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.

Journal Article J Biol Chem · October 20, 2017 The neonatal Fc receptor FcRn plays a critical role in the trafficking of IgGs across tissue barriers and in retaining high circulating concentrations of both IgG and albumin. Although generally beneficial from an immunological perspective in maintaining I ... Full text Link to item Cite

The Antimicrobial Scrub Contamination and Transmission (ASCOT) Trial: A Three-Arm, Blinded, Randomized Controlled Trial With Crossover Design to Determine the Efficacy of Antimicrobial-Impregnated Scrubs in Preventing Healthcare Provider Contamination.

Journal Article Infect Control Hosp Epidemiol · October 2017 OBJECTIVE To determine whether antimicrobial-impregnated textiles decrease the acquisition of pathogens by healthcare provider (HCP) clothing. DESIGN We completed a 3-arm randomized controlled trial to test the efficacy of 2 types of antimicrobial-impregna ... Full text Link to item Cite

2D-LC-MS/MS to measure cleaved high-molecular-weight kininogen in human plasma as a biomarker for C1-INH-HAE.

Journal Article Bioanalysis · October 2017 AIM: C1-INH-HAE is caused by activation of plasma kallikrein which subsequently cleaves high-molecular-weight kininogen (HMWK) to generate bradykinin and cHMWK. MATERIALS & METHODS: A novel ion-pair 2D LC-MS/MS assay was developed to measure the 46 kDa cHM ... Full text Link to item Cite

Influence of vancomycin minimum inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus left-sided infective endocarditis treated with antistaphylococcal β-lactam antibiotics: a prospective cohort study by the International Collaboration on Endocarditis.

Journal Article Clin Microbiol Infect · August 2017 OBJECTIVES: Left-sided methicillin-susceptible Staphylococcus aureus (MSSA) endocarditis treated with cloxacillin has a poorer prognosis when the vancomycin minimum inhibitory concentration (MIC) is ≥1.5 mg/L. We aimed to validate this using the Internatio ... Full text Open Access Link to item Cite

Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation.

Journal Article Clin Infect Dis · April 1, 2017 BACKGROUND: Nontuberculous mycobacteria (NTM) commonly colonize municipal water supplies and cause healthcare-associated outbreaks. We investigated a biphasic outbreak of Mycobacterium abscessus at a tertiary care hospital. METHODS: Case patients had recen ... Full text Link to item Cite

Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomised, multicentre, crossover study.

Journal Article Lancet · February 25, 2017 BACKGROUND: Patients admitted to hospital can acquire multidrug-resistant organisms and Clostridium difficile from inadequately disinfected environmental surfaces. We determined the effect of three enhanced strategies for terminal room disinfection (disinf ... Full text Link to item Cite

Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis.

Journal Article N Engl J Med · February 23, 2017 BACKGROUND: Hereditary angioedema with C1 inhibitor deficiency is characterized by recurrent, unpredictable swelling episodes caused by uncontrolled plasma kallikrein generation and excessive bradykinin release resulting from cleavage of high-molecular-wei ... Full text Link to item Cite

Clinical Outcomes and Healthcare Utilization Related to Multidrug-Resistant Gram-Negative Infections in Community Hospitals.

Journal Article Infect Control Hosp Epidemiol · January 2017 OBJECTIVE To evaluate the impact of multidrug-resistant gram-negative rod (MDR-GNR) infections on mortality and healthcare resource utilization in community hospitals. DESIGN Two matched case-control analyses. SETTING Six community hospitals participating ... Full text Link to item Cite

Identification of novel risk factors for community-acquired Clostridium difficile infection using spatial statistics and geographic information system analyses.

Journal Article PLoS One · 2017 BACKGROUND: The rate of community-acquired Clostridium difficile infection (CA-CDI) is increasing. While receipt of antibiotics remains an important risk factor for CDI, studies related to acquisition of C. difficile outside of hospitals are lacking. As a ... Full text Open Access Link to item Cite

Assessment of Self-Contamination During Removal of Personal Protective Equipment for Ebola Patient Care.

Journal Article Infect Control Hosp Epidemiol · October 2016 OBJECTIVE Ebola virus disease (EVD) places healthcare personnel (HCP) at high risk for infection during patient care, and personal protective equipment (PPE) is critical. Protocols for EVD PPE doffing have not been validated for prevention of viral self-co ... Full text Link to item Cite

A Multicenter Pragmatic Interrupted Time Series Analysis of Chlorhexidine Gluconate Bathing in Community Hospital Intensive Care Units.

Journal Article Infect Control Hosp Epidemiol · July 2016 OBJECTIVE To determine whether daily chlorhexidine gluconate (CHG) bathing of intensive care unit (ICU) patients leads to a decrease in hospital-acquired infections (HAIs), particularly infections caused by methicillin-resistant Staphylococcus aureus (MRSA ... Full text Link to item Cite

Epidemiology of Surgical Site Infection in a Community Hospital Network.

Journal Article Infect Control Hosp Epidemiol · May 2016 OBJECTIVE: To describe the epidemiology of complex surgical site infection (SSI) following commonly performed surgical procedures in community hospitals and to characterize trends of SSI prevalence rates over time for MRSA and other common pathogens METHOD ... Full text Link to item Cite

A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation.

Journal Article Thromb Res · April 2016 Studies with animal models implicate the plasma proteases factor XIIa (FXIIa) and α-kallikrein in arterial and venous thrombosis. As congenital deficiencies of factor XII (FXII) or prekallikrein (PK), the zymogens of FXIIa and α-kallikrein respectively, do ... Full text Link to item Cite

Increasing Incidence of Extended-Spectrum β-Lactamase-Producing Escherichia coli in Community Hospitals throughout the Southeastern United States.

Journal Article Infect Control Hosp Epidemiol · January 2016 OBJECTIVE To describe the epidemiology of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (ESBL-EC) and Klebsiella pneumoniae (ESBL-KP) infections DESIGN Retrospective cohort SETTING Inpatient care at community hospitals PATIENTS All patien ... Full text Link to item Cite

Short Operative Duration and Surgical Site Infection Risk in Hip and Knee Arthroplasty Procedures.

Journal Article Infect Control Hosp Epidemiol · December 2015 OBJECTIVE: To determine the association (1) between shorter operative duration and surgical site infection (SSI) and (2) between surgeon median operative duration and SSI risk among first-time hip and knee arthroplasties. DESIGN: Retrospective cohort study ... Full text Link to item Cite

Seasonal Variation of Common Surgical Site Infections: Does Season Matter?

Journal Article Infect Control Hosp Epidemiol · September 2015 OBJECTIVE: To evaluate seasonal variation in the rate of surgical site infections (SSI) following commonly performed surgical procedures. DESIGN: Retrospective cohort study. METHODS: We analyzed 6 years (January 1, 2007, through December 31, 2012) of data ... Full text Link to item Cite

Challenges in Preparation of Cumulative Antibiogram Reports for Community Hospitals.

Journal Article J Clin Microbiol · September 2015 Knowledge of local antimicrobial resistance is critical for management of infectious diseases. Community hospitals' compliance with Clinical and Laboratory Standards Institute (CLSI) guidance for creation of cumulative antibiograms is uncertain. This descr ... Full text Link to item Cite

Postoperative infection in spine surgery: does the month matter?

Journal Article J Neurosurg Spine · July 2015 OBJECT: The relationship between time of year and surgical site infection (SSI) following neurosurgical procedures is poorly understood. Authors of previous reports have demonstrated that rates of SSI following neurosurgical procedures performed during the ... Full text Link to item Cite

Delay in diagnosis of invasive surgical site infections following knee arthroplasty versus hip arthroplasty.

Journal Article Clin Infect Dis · April 1, 2015 BACKGROUND: The timing of diagnosis of invasive surgical site infection (SSI) following joint replacement surgery is an important criterion used to determine subsequent medical and surgical management. METHODS: We compared time to diagnosis of invasive SSI ... Full text Link to item Cite

Candida infective endocarditis: an observational cohort study with a focus on therapy.

Journal Article Antimicrob Agents Chemother · April 2015 Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and u ... Full text Link to item Cite

The potential impact of excluding funguria from the surveillance definition of catheter-associated urinary tract infection.

Journal Article Infect Control Hosp Epidemiol · April 2015 Funguria rarely represents true infection in the urinary tract. Excluding yeast from the catheter-associated urinary tract infection (CAUTI) surveillance definition reduced CAUTI rates by nearly 25% in community hospitals and at an academic, tertiary-care ... Full text Link to item Cite

Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study.

Journal Article Clin Infect Dis · March 1, 2015 BACKGROUND: The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the fir ... Full text Link to item Cite

A comparison between National Healthcare Safety Network laboratory-identified event reporting versus traditional surveillance for Clostridium difficile infection.

Journal Article Infect Control Hosp Epidemiol · February 2015 OBJECTIVE Hospitals in the National Healthcare Safety Network began reporting laboratory-identified (LabID) Clostridium difficile infection (CDI) events in January 2013. Our study quantified the differences between the LabID and traditional surveillance me ... Full text Link to item Cite

The preventability of ventilator-associated events. The CDC Prevention Epicenters Wake Up and Breathe Collaborative.

Journal Article Am J Respir Crit Care Med · February 1, 2015 RATIONALE: The CDC introduced ventilator-associated event (VAE) definitions in January 2013. Little is known about VAE prevention. We hypothesized that daily, coordinated spontaneous awakening trials (SATs) and spontaneous breathing trials (SBTs) might pre ... Full text Link to item Cite

One-year outcome following biological or mechanical valve replacement for infective endocarditis.

Journal Article Int J Cardiol · January 15, 2015 BACKGROUND: Nearly half of patients require cardiac surgery during the acute phase of infective endocarditis (IE). We describe the characteristics of patients according to the type of valve replacement (mechanical or biological), and examine whether the ty ... Full text Link to item Cite

Association between surgical indications, operative risk, and clinical outcome in infective endocarditis: a prospective study from the International Collaboration on Endocarditis.

Journal Article Circulation · January 13, 2015 BACKGROUND: Use of surgery for the treatment of infective endocarditis (IE) as related to surgical indications and operative risk for mortality has not been well defined. METHODS AND RESULTS: The International Collaboration on Endocarditis-PLUS (ICE-PLUS) ... Full text Link to item Cite

Staphylococcus aureus infections following knee and hip prosthesis insertion procedures.

Journal Article Antimicrob Resist Infect Control · 2015 BACKGROUND: Staphylococcus aureus is the most common and most important pathogen following knee and hip arthroplasty procedures. Understanding the epidemiology of invasive S. aureus infections is important to quantify this serious complication. METHODS: Th ... Full text Link to item Cite

Fully human monoclonal antibody inhibitors of the neonatal fc receptor reduce circulating IgG in non-human primates.

Journal Article Front Immunol · 2015 The therapeutic management of antibody-mediated autoimmune disease typically involves immunosuppressant and immunomodulatory strategies. However, perturbing the fundamental role of the neonatal Fc receptor (FcRn) in salvaging IgG from lysosomal degradation ... Full text Link to item Cite

Epidemiology of methicillin-resistant Staphylococcus aureus pneumonia in community hospitals.

Journal Article Infect Control Hosp Epidemiol · December 2014 OBJECTIVE: Describe the epidemiology of healthcare-related (ie, healthcare-associated and hospital-acquired) pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA) among hospitalized patients in community hospitals. DESIGN: Retrospective cohor ... Full text Link to item Cite

Whole Genome Sequencing of a Methicillin-Resistant Staphylococcus aureus Pseudo-Outbreak in a Professional Football Team.

Journal Article Open Forum Infect Dis · December 2014 Two American football players on the same team were diagnosed with methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections on the same day. Our investigation, including whole genome sequencing, confirmed that players did not tran ... Full text Open Access Link to item Cite

Methicillin-resistant Staphylococcus aureus bloodstream infection surveillance: National Healthcare Safety Network's laboratory-identified event reporting versus traditional laboratory-confirmed bloodstream infection surveillance.

Journal Article Infect Control Hosp Epidemiol · October 2014 Hospitals must report cases of methicillin-resistant Staphylococcus aureus bloodstream infection (BSI) using a new laboratory-identified (LabID) event reporting module. BSI rates obtained using LabID differ from rates of BSI obtained from traditional surve ... Full text Link to item Cite

A phase 1 study investigating DX-2930 in healthy subjects.

Journal Article Ann Allergy Asthma Immunol · October 2014 BACKGROUND: DX-2930 is a human monoclonal antibody inhibitor of plasma kallikrein under investigation for long-term prophylaxis of hereditary angioedema. OBJECTIVE: To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of DX-2930 in he ... Full text Link to item Cite

Necrotizing fasciitis caused by Haemophilus influenzae serotype f.

Journal Article J Clin Microbiol · September 2014 Haemophilus influenzae is a rare cause of soft tissue infection. In this report, we present a case of multifocal necrotizing fasciitis in a healthy adult patient, secondary to Haemophilus influenzae serotype f infection, and we review literature on this ra ... Full text Link to item Cite

Inhibition of plasma kallikrein by a highly specific active site blocking antibody.

Journal Article J Biol Chem · August 22, 2014 Plasma kallikrein (pKal) proteolytically cleaves high molecular weight kininogen to generate the potent vasodilator and the pro-inflammatory peptide, bradykinin. pKal activity is tightly regulated in healthy individuals by the serpin C1-inhibitor, but indi ... Full text Link to item Cite

Rising rates of carbapenem-resistant enterobacteriaceae in community hospitals: a mixed-methods review of epidemiology and microbiology practices in a network of community hospitals in the southeastern United States.

Journal Article Infect Control Hosp Epidemiol · August 2014 OBJECTIVE: Describe the epidemiology of carbapenem-resistant Enterobacteriaceae (CRE) and examine the effect of lower carbapenem breakpoints on CRE detection. DESIGN: Retrospective cohort. SETTING: Inpatient care at community hospitals. PATIENTS: All patie ... Full text Link to item Cite

A comparison of environmental contamination by patients infected or colonized with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci: a multicenter study.

Journal Article Infect Control Hosp Epidemiol · July 2014 A total of 1,023 environmental surfaces were sampled from 45 rooms with patients infected or colonized with methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant enterococci (VRE) before terminal room cleaning. Colonized patients had h ... Full text Link to item Cite

Repeat endocarditis: analysis of risk factors based on the International Collaboration on Endocarditis - Prospective Cohort Study.

Journal Article Clin Microbiol Infect · June 2014 Repeat episodes of infective endocarditis (IE) can occur in patients who survive an initial episode. We analysed risk factors and 1-year mortality of patients with repeat IE. We considered 1874 patients enrolled in the International Collaboration on Endoca ... Full text Link to item Cite

Surveying the surveillance: surgical site infections excluded by the January 2013 updated surveillance definitions.

Journal Article Infect Control Hosp Epidemiol · May 2014 The updated 2013 Centers for Disease Control and Prevention/National Healthcare Safety Network definitions for surgical site infections (SSIs) reduced the duration of prolonged surveillance from 1 year to 90 days and defined which procedure types require p ... Full text Link to item Cite

Outbreak of bacteremia due to Burkholderia contaminans linked to intravenous fentanyl from an institutional compounding pharmacy.

Journal Article JAMA Intern Med · April 2014 IMPORTANCE Many health care facilities compound medications on site to fulfill local demands when customized formulations are needed, national supply is critically low, or costs for manufactured pharmaceuticals are excessive. Small, institutional compoundi ... Full text Link to item Cite

Widespread dissemination of CTX-M-15 genotype extended-spectrum-β-lactamase-producing enterobacteriaceae among patients presenting to community hospitals in the southeastern United States.

Journal Article Antimicrob Agents Chemother · 2014 Extended-spectrum-β-lactamase (ESBL)-producing organisms are increasingly prevalent. We determined the characteristics of 66 consecutive ESBL-producing isolates from six community hospitals in North Carolina and Virginia from 2010 to 2012. Fifty-three (80% ... Full text Link to item Cite

Bloodstream infections in community hospitals in the 21st century: a multicenter cohort study.

Journal Article PLoS One · 2014 BACKGROUND: While the majority of healthcare in the US is provided in community hospitals, the epidemiology and treatment of bloodstream infections in this setting is unknown. METHODS AND FINDINGS: We undertook this multicenter, retrospective cohort study ... Full text Open Access Link to item Cite

Drugs derived from phage display: from candidate identification to clinical practice.

Journal Article MAbs · 2014 Phage display, one of today’s fundamental drug discovery technologies, allows identification of a broad range of biological drugs, including peptides, antibodies and other proteins, with the ability to tailor critical characteristics such as potency, speci ... Full text Link to item Cite

In-hospital and 1-year mortality in patients undergoing early surgery for prosthetic valve endocarditis.

Journal Article JAMA Intern Med · September 9, 2013 IMPORTANCE: There are limited prospective, controlled data evaluating survival in patients receiving early surgery vs medical therapy for prosthetic valve endocarditis (PVE). OBJECTIVE: To determine the in-hospital and 1-year mortality in patients with PVE ... Full text Link to item Cite

Diagnostic dilemma in a returning traveler with fever.

Journal Article Diagn Microbiol Infect Dis · September 2013 This case report of fever of unknown origin in a returning traveler from South America illustrates the need for a thorough understanding of limitations of laboratory testing modalities in order to prevent delays in diagnosis in potentially fatal but curabl ... Full text Link to item Cite

Comparison of non-intensive care unit (ICU) versus ICU rates of catheter-associated urinary tract infection in community hospitals.

Journal Article Infect Control Hosp Epidemiol · July 2013 We describe and compare the epidemiology of catheter-associated urinary tract infection (CAUTI) occurring in non-intensive care unit (ICU) versus ICU wards in a network of community hospitals over a 2-year period. Overall, 72% of cases of CAUTI occurred in ... Full text Link to item Cite

The epidemiology of ventilator-associated pneumonia in a network of community hospitals: a prospective multicenter study.

Journal Article Infect Control Hosp Epidemiol · July 2013 OBJECTIVE: To describe the epidemiology of ventilator-associated pneumonia (VAP) in community hospitals. DESIGN AND SETTING: Prospective study in 31 community hospitals from 2007 to 2011. METHODS: VAP surveillance was performed by infection preventionists ... Full text Link to item Cite

A homogeneous fluorescence anisotropy assay for measuring transglutaminase 2 activity.

Journal Article Anal Biochem · May 1, 2013 Transglutaminases catalyze the covalent linkage of protein polypeptides through their glutamine and lysine side chains. Tissue transglutaminase 2 (TG2) has been of particular interest given its potential role in several disorders, including a variety of ca ... Full text Link to item Cite

Decontamination of targeted pathogens from patient rooms using an automated ultraviolet-C-emitting device.

Journal Article Infect Control Hosp Epidemiol · May 2013 OBJECTIVE. To determine the effectiveness of an automated ultraviolet-C (UV-C) emitter against vancomycin-resistant enterococci (VRE), Clostridium difficile, and Acinetobacter spp. in patient rooms. DESIGN. Prospective cohort study. SETTING. Two tertiary c ... Full text Link to item Cite

Role of the environment in the transmission of Clostridium difficile in health care facilities.

Journal Article Am J Infect Control · May 2013 Recent data demonstrate that the contaminated hospital surface environment plays a key role in the transmission of Clostridium difficile. Enhanced environmental cleaning of rooms housing Clostridium difficile-infected patients is warranted, and, if additio ... Full text Link to item Cite

Diagnosis and management of Q fever--United States, 2013: recommendations from CDC and the Q Fever Working Group.

Journal Article MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control · March 29, 2013 Q fever, a zoonotic disease caused by the bacterium Coxiella burnetii, can cause acute or chronic illness in humans. Transmission occurs primarily through inhalation of aerosols from contaminated soil or animal waste. No licensed vaccine is available in th ... Cite

Diagnosis and management of Q fever--United States, 2013: recommendations from CDC and the Q Fever Working Group.

Journal Article MMWR Recomm Rep · March 29, 2013 Q fever, a zoonotic disease caused by the bacterium Coxiella burnetii, can cause acute or chronic illness in humans. Transmission occurs primarily through inhalation of aerosols from contaminated soil or animal waste. No licensed vaccine is available in th ... Link to item Cite

Central line-associated infections as defined by the Centers for Medicare and Medicaid Services' Hospital-acquired condition versus standard infection control surveillance: why hospital compare seems conflicted.

Journal Article Infect Control Hosp Epidemiol · March 2013 OBJECTIVE: To evaluate the concordance of case-finding methods for central line-associated infection as defined by Centers for Medicare and Medicaid Services (CMS) hospital-acquired condition (HAC) compared with traditional infection control (IC) methods. ... Full text Link to item Cite

Observing and improving hand hygiene compliance: implementation and refinement of an electronic-assisted direct-observer hand hygiene audit program.

Journal Article Infect Control Hosp Epidemiol · February 2013 We implemented a direct-observer hand hygiene audit program that used trained observers, wireless data entry devices, and an intranet portal. We improved the reliability and utility of the data by standardizing audit processes, regularly retraining auditor ... Full text Link to item Cite

Diagnosis and management of Q fever - United States, 2013: Recommendations from CDC and the Q Fever Working Group

Journal Article MMWR Recommendations and Reports · January 1, 2013 Q fever, a zoonotic disease caused by the bacterium Coxiella burnetii, can cause acute or chronic illness in humans. Transmission occurs primarily through inhalation of aerosols from contaminated soil or animal waste. No licensed vaccine is available in th ... Cite

Metastatic complications of bloodstream infections in hemodialysis patients.

Journal Article Semin Dial · 2013 Bacteremia is a common infectious complication in hemodialysis patients. Metastatic sites of infection including infective endocarditis, vertebral osteomyelitis, spinal epidural abscess, and septic arthritis occur relatively frequently. These complications ... Full text Link to item Cite

Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke.

Journal Article Clin Infect Dis · January 2013 BACKGROUND: The timing of cardiac surgery after stroke in infective endocarditis (IE) remains controversial. We examined the relationship between the timing of surgery after stroke and the incidence of in-hospital and 1-year mortalities. METHODS: Data were ... Full text Link to item Cite

HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort.

Journal Article PLoS One · 2013 The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics a ... Full text Link to item Cite

Delays in appropriate antibiotic therapy for gram-negative bloodstream infections: a multicenter, community hospital study.

Journal Article PLoS One · 2013 BACKGROUND: Gram-negative bacterial bloodstream infection (BSI) is a serious condition with estimated 30% mortality. Clinical outcomes for patients with severe infections improve when antibiotics are appropriately chosen and given early. The objective of t ... Full text Open Access Link to item Cite

Role of plasma kallikrein-kinin system activation in synovial recruitment of endothelial progenitor cells in experimental arthritis.

Journal Article Arthritis Rheum · November 2012 OBJECTIVE: To examine whether activation of the plasma kallikrein-kinin system (KKS) mediates synovial recruitment of endothelial progenitor cells (EPCs) in arthritis. METHODS: EPCs were isolated from Lewis rat bone marrow, and expression of progenitor cel ... Full text Link to item Cite

"What the eyes don't see, the heart doesn't grieve over": epidemiology and risk factors for bloodstream infections following cardiac catheterization.

Journal Article Infect Control Hosp Epidemiol · August 2012 No standard definition exists for surveillance and characterization of the epidemiology of bloodstream infections (BSIs) after cardiac catheterization (CC) procedures. We proposed a novel case definition and determined the epidemiology and risk factors of ... Full text Link to item Cite

Fibrin specific peptides derived by phage display: characterization of peptides and conjugates for imaging.

Journal Article Bioconjug Chem · March 21, 2012 Peptides that bind to fibrin but not to fibrinogen or serum albumin were selected from phage display libraries as targeting moieties for thrombus molecular imaging probes. Three classes of cyclic peptides (cyclized via disulfide bond between two Cys) were ... Full text Link to item Cite

The impact of depth of infection and postdischarge surveillance on rate of surgical-site infections in a network of community hospitals.

Journal Article Infect Control Hosp Epidemiol · March 2012 OBJECTIVE: To describe the epidemiology of surgical-site infections (SSIs) in community hospitals and to explore the impact of depth of SSI, healthcare location at the time of diagnosis, and variations in surveillance practices on the overall rate of SSI. ... Full text Link to item Cite

Spotted Fever Group Rickettsioses

Journal Article · December 1, 2011 Full text Cite

Surgical site infections following bariatric surgery in community hospitals: a weighty concern?

Journal Article Obes Surg · July 2011 BACKGROUND: Although obesity is a well-known risk factor for surgical site infection (SSI), specific risk factors for SSI among obese patients undergoing bariatric surgery (BS) have not been well-defined. METHODS: We performed a prospective cohort study on ... Full text Link to item Cite

Blood culture contamination with Enterococci and skin organisms: implications for surveillance definitions of primary bloodstream infections.

Journal Article Am J Infect Control · June 2011 Enterococci are a common cause of bacteremia but are also common contaminants. In our institution, approximately 17% of positive blood cultures with enterococci are mixed with skin organisms. Such isolates are probable contaminants. The specificity of the ... Full text Link to item Cite

Comparison of the burdens of hospital-onset, healthcare facility-associated Clostridium difficile Infection and of healthcare-associated infection due to methicillin-resistant Staphylococcus aureus in community hospitals.

Journal Article Infect Control Hosp Epidemiol · April 2011 Featured Publication We sought to determine the burden of nosocomial Clostridium difficile infection in comparison to other healthcare-associated infections (HAIs) in community hospitals participating in an infection control network. Our data suggest that C. difficile has repl ... Full text Link to item Cite

The network approach for prevention of healthcare-associated infections: long-term effect of participation in the Duke Infection Control Outreach Network.

Journal Article Infect Control Hosp Epidemiol · April 2011 Featured Publication OBJECTIVE: To describe the rates of several key outcomes and healthcare-associated infections (HAIs) among hospitals that participated in the Duke Infection Control Outreach Network (DICON). DESIGN AND SETTING: Prospective, observational cohort study of pa ... Full text Link to item Cite

Cluster of oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infections on a hospital ward among immunocompromised patients--North Carolina, 2009.

Journal Article J Infect Dis · March 15, 2011 BACKGROUND: Oseltamivir resistance among 2009 pandemic influenza A (H1N1) viruses (pH1N1) is rare. We investigated a cluster of oseltamivir-resistant pH1N1 infections in a hospital ward. METHODS: We reviewed patient records and infection control measures a ... Full text Link to item Cite

Selection and Screening of Antibody Phage Display Libraries

Chapter · January 1, 2011 The following sections are included: Introduction Antibody Gene Rearrangement and Variable Region Sequence Diversity Antibody architecture and germline gene segment recombination Variable region sequence diversity and structure guiding library design Ampli ... Full text Cite

Evaluation of an evidence-based, nurse-driven checklist to prevent hospital-acquired catheter-associated urinary tract infections in intensive care units.

Journal Article J Nurs Care Qual · 2011 Catheter-associated urinary tract infections account for 40% of all health care-associated infections. An evidence-based, nurse-driven daily checklist for initiation and continuance of urinary catheters was implemented in 5 adult intensive care units. Meas ... Full text Link to item Cite

Revisiting the effect of referral bias on the clinical spectrum of infective endocarditis in adults.

Journal Article Eur J Clin Microbiol Infect Dis · October 2010 Referral bias occurs because of the clustering of patients at tertiary care centers. This may result in the distortion of observed clinical manifestations of rare diseases. This analysis evaluates the effect of referral bias on the epidemiology of infectiv ... Full text Link to item Cite

Reply to Fe Talento et al

Journal Article Infection Control & Hospital Epidemiology · September 2010 Full text Open Access Cite

Variation in the type and frequency of postoperative invasive Staphylococcus aureus infections according to type of surgical procedure.

Journal Article Infect Control Hosp Epidemiol · July 2010 OBJECTIVE: To determine the epidemiological characteristics of postoperative invasive Staphylococcus aureus infection following 4 types of major surgical procedures.design. Retrospective cohort study. SETTING: Eleven hospitals (9 community hospitals and 2 ... Full text Open Access Link to item Cite

Acute eosinophilic pneumonia secondary to daptomycin: a report of three cases.

Journal Article Clin Infect Dis · June 1, 2010 We describe 3 cases of daptomycin-induced pulmonary toxic effects that are consistent with drug-induced acute eosinophilic pneumonia. Patients presented similarly with dyspnea, cough, hypoxia, and diffuse ground-glass opacities at chest computed tomography ... Full text Open Access Link to item Cite

Hacek

Chapter · January 1, 2010 The acronym HACEK describes a heterogeneous group of organisms that share three major characteristics. First, they are small gram-negative rods that are commonly present as part of normal oral–pharyngeal or respiratory flora. Second, they are fastidious mi ... Full text Cite

Validating a 3-point prediction rule for surgical site infection after coronary artery bypass surgery.

Journal Article Infect Control Hosp Epidemiol · January 2010 BACKGROUND: Surgical site infection (SSI) after coronary artery bypass graft (CABG) surgery is an increasing healthcare problem. Investigators from Australia proposed a new, 3-point scale that assesses SSI risk on the basis of diagnosis of diabetes mellitu ... Full text Link to item Cite

Clinical and financial outcomes due to methicillin resistant Staphylococcus aureus surgical site infection: a multi-center matched outcomes study.

Journal Article PLoS One · December 15, 2009 BACKGROUND: The clinical and financial outcomes of SSIs directly attributable to MRSA and methicillin-resistance are largely uncharacterized. Previously published data have provided conflicting conclusions. METHODOLOGY: We conducted a multi-center matched ... Full text Link to item Cite

Empirical antimicrobial therapy for bloodstream infection due to methicillin-resistant Staphylococcus aureus: no better than a coin toss.

Journal Article Infect Control Hosp Epidemiol · November 2009 BACKGROUND: Despite the high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection in the hospital, the proportion of patients with MRSA bacteremia who receive appropriate empirical therapy remains suboptimal. OBJECTIVE: To investigate ... Full text Link to item Cite

Seasonal peaks in Escherichia coli infections: possible explanations and implications.

Journal Article Clin Microbiol Infect · October 2009 Escherichia coli is a common cause of infections in all populations and countries of the world, causing an enormous burden of disease. In this issue of Clinical Microbiology and Infection, Al-Hasan et al. describe seasonal peaks in the incidence of E. coli ... Full text Link to item Cite

Postoperative joint infections due to Propionibacterium species: a case-control study.

Journal Article Clin Infect Dis · October 1, 2009 We compared 40 patients with Propionibacterium acnes postoperative joint infection to a cohort of uninfected patients. Infection manifested a median of 210 days after surgery. Most patients with joint prostheses underwent hardware removal. Prior joint surg ... Full text Link to item Cite

Patient-days: a better measure of incidence of occupational bloodborne exposures.

Journal Article Am J Infect Control · September 2009 BACKGROUND: There is currently no accepted standard denominator to calculate and to report the incidence of occupational exposures to bloodborne pathogens (OEBBPs) in health care. METHODS: We performed a multicenter study of OEBBP injuries reported from 31 ... Full text Link to item Cite

Legionella as a cause of hyperpyrexia.

Journal Article Clin Infect Dis · August 15, 2009 Full text Link to item Cite

Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases.

Journal Article Biochem J · August 13, 2009 KLK1 (tissue kallikrein 1) is a member of the tissue kallikrein family of serine proteases and is the primary kinin-generating enzyme in human airways. DX-2300 is a fully human antibody that inhibits KLK1 via a competitive inhibition mechanism (Ki=0.13 nM) ... Full text Link to item Cite

Emergence of extended-spectrum beta-lactamase-producing Escherichia coli in community hospitals throughout North Carolina: a harbinger of a wider problem in the United States?

Journal Article Clin Infect Dis · July 15, 2009 Featured Publication Community-onset urinary tract infections due to extended-spectrum beta-lactamase-producing Escherichia coli have become increasingly common worldwide but have been considered to be uncommon infections in the United States. We report the emergence and subse ... Full text Link to item Cite

Law of unintended consequences and Medicare's new reimbursement rules

Journal Article Infectious Diseases in Clinical Practice · July 1, 2009 Full text Cite

Risk factors for gram-negative bacterial surgical site infection: do allergies to antibiotics increase risk?

Journal Article Infect Control Hosp Epidemiol · May 2009 OBJECTIVE: To determine the relationship between inadequate antimicrobial prophylaxis and development of gram-negative bacterial (GNB) surgical site infection (SSI). DESIGN: Retrospective case-control study. SETTING: A 369-bed acute care community hospital ... Full text Link to item Cite

Coagulase-negative staphylococcal prosthetic valve endocarditis--a contemporary update based on the International Collaboration on Endocarditis: prospective cohort study.

Journal Article Heart · April 2009 OBJECTIVE: To describe the contemporary features of coagulase-negative staphylococcal (CoNS) prosthetic valve endocarditis (PVE). DESIGN: Observational study of prospectively collected data from a multinational cohort of patients with infective endocarditi ... Full text Link to item Cite

Living arrangement and coronary heart disease: the JPHC study.

Journal Article Heart · April 2009 BACKGROUND: Previous studies have suggested that living in a multi-generational household (a type of family structure prevalent in Japan) confers mixed health benefits and stresses, especially for women who report such living arrangements. OBJECTIVE: To ex ... Full text Link to item Cite

Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis.

Journal Article Cancer Res · February 15, 2009 Inhibition of specific matrix metalloproteinases (MMP) is an attractive noncytotoxic approach to cancer therapy. MMP-14, a membrane-bound zinc endopeptidase, has been proposed to play a central role in tumor growth, invasion, and neovascularization. Beside ... Full text Link to item Cite

Scrub typhus and rickettsial diseases in international travelers: a review.

Journal Article Curr Infect Dis Rep · January 2009 Physicians caring for febrile returned travelers face the difficult task of recognizing the typical and atypical features of more than 16 known rickettsial diseases and separating these diseases from potentially serious nonrickettsial diseases. Currently a ... Full text Link to item Cite

The effect of surgical site infection on older operative patients.

Journal Article J Am Geriatr Soc · January 2009 OBJECTIVES: To determine the effect of surgical site infection (SSI) on mortality, duration of hospitalization, and hospital cost in older operative patients. DESIGN: Retrospective matched-outcomes study. SETTING: Eight hospitals, including Duke University ... Full text Link to item Cite

Clinical and financial outcomes due to methicillin resistant staphylococcus aureus surgical site infection: A multi-center matched outcomes study

Journal Article PLoS ONE · 2009 Background: The clinical and financial outcomes of SSIs directly attributable to MRSA and methicillin-resistance are largely uncharacterized. Previously published data have provided conflicting conclusions. Methodology: We conducted a multi-center matched ... Full text Cite

Current features of infective endocarditis in elderly patients: results of the International Collaboration on Endocarditis Prospective Cohort Study.

Journal Article Arch Intern Med · October 27, 2008 BACKGROUND: Elderly patients are emerging as a population at high risk for infective endocarditis (IE). However, adequately sized prospective studies on the features of IE in elderly patients are lacking. METHODS: In this multinational, prospective, observ ... Full text Link to item Cite

Infectious complications following endoscopic retrograde cholangiopancreatography: an automated surveillance system for detecting postprocedure bacteremia.

Journal Article Am J Infect Control · October 2008 We have developed an automated surveillance system to detect bloodstream infection (BSI) occurring after endoscopic retrograde cholangiopancreatography (ERCP). We retrospectively applied this automated surveillance tool to all patients who underwent ERCP a ... Full text Link to item Cite

Complex surgical site infections and the devilish details of risk adjustment: important implications for public reporting.

Journal Article Infect Control Hosp Epidemiol · October 2008 OBJECTIVE: To validate the National Nosocomial Infection Surveillance (NNIS) risk index as a tool to account for differences in case mix when reporting rates of complex surgical site infection (SSI). DESIGN: Prospective cohort study. SETTING: Twenty-four c ... Full text Link to item Cite

What's new in Rocky Mountain spotted fever?

Journal Article Infect Dis Clin North Am · September 2008 Rocky Mountain spotted fever (RMSF) remains an important illness despite an effective therapy because it is difficult to diagnose and is capable of producing a fatal outcome. The pathogenesis of RMSF remains, in large part, an enigma. However, recent resea ... Full text Link to item Cite

Poor functional status as a risk factor for surgical site infection due to methicillin-resistant Staphylococcus aureus.

Journal Article Infect Control Hosp Epidemiol · September 2008 OBJECTIVE: To identify risk factors for surgical site infection (SSI) due to methicillin-resistant Staphylococcus aureus (MRSA). DESIGN: Prospective case-control study. SETTING: One tertiary and 6 community-based institutions in the southeastern United Sta ... Full text Link to item Cite

Treatment of TIPS/biliary fistula-related endotipsitis with a covered stent.

Journal Article J Vasc Interv Radiol · June 2008 "Infective endotipsitis" describes a recurrent bacteremia or fungemia in patients with a transjugular intrahepatic portosystemic shunt (TIPS) in place and no other identifiable source of infection. The present report describes a patient who developed polym ... Full text Link to item Cite

The deadly toll of invasive methicillin-resistant Staphylococcus aureus infection in community hospitals.

Journal Article Clin Infect Dis · May 15, 2008 INTRODUCTION: Data regarding the epidemiology, treatment, and outcomes of methicillin-resistant Staphylococcus aureus (MRSA) infections in rural and community hospitals are limited. METHODS: This cohort study was conducted at 1 tertiary care hospital and 8 ... Full text Link to item Cite

Echocardiographic risk stratification for early surgery with endocarditis: a cost-effectiveness analysis.

Journal Article Heart · May 2008 BACKGROUND: Despite widespread acceptance of echocardiography for diagnosis of infective endocarditis, few investigators have evaluated its utility as a risk-stratification tool to aid therapeutic decision-making. METHODS: A decision tree and Markov analys ... Full text Link to item Cite

Risk factors for bloodstream infections in older hospitalized patients: A multi-center study

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 1, 2008 Link to item Cite

Seasonal variation in Klebsiella pneumoniae bloodstream infection on 4 continents.

Journal Article J Infect Dis · March 1, 2008 BACKGROUND: Klebsiella pneumoniae causes serious, life-threatening infections in humans in endemic and epidemic settings. The objective of this study was to determine whether the incidence of K. pneumoniae bloodstream infection (BSI) was higher during warm ... Full text Link to item Cite

Obesity and mode of delivery in primigravid and multigravid women.

Journal Article Am J Perinatol · March 2008 Our objective was to study the effects of maternal body mass index (BMI) on the mode of delivery for primigravid and multigravid women. A retrospective cohort study was conducted at the University College Hospital Galway, Ireland, of 5162 women delivered f ... Full text Link to item Cite

Leptotrichia endocarditis: report of two cases from the International Collaboration on Endocarditis (ICE) database and review of previous cases.

Journal Article Eur J Clin Microbiol Infect Dis · February 2008 Leptotrichia species typically colonize the oral cavity and genitourinary tract. We report the first two cases of endocarditis secondary to L. goodfellowii sp. nov. Both cases were identified using 16S rRNA gene sequencing. Review of the English literature ... Full text Link to item Cite

Expression levels of mRNA for Rho A/Rho kinase and its role in isoprostane-induced vasoconstriction of human placental and maternal vessels.

Journal Article Reprod Sci · February 2008 Preeclampsia is characterized by intense and prolonged vasoconstriction. Rho A-mediated calcium sensitization is central to prolonged contractility of vascular smooth muscle. The aims of this study are (1) to investigate mRNA expression levels of Rho A/Rho ... Full text Link to item Cite

Surgical volume and the risk of surgical site infection in community hospitals: size matters.

Journal Article Ann Surg · February 2008 OBJECTIVE: To determine if surgical volume affects the risk of surgical site infections (SSI) in community hospitals. BACKGROUND: The utility of public reporting and the optimal methods to employ when reporting SSI rates remain controversial and contentiou ... Full text Link to item Cite

Non-HACEK gram-negative bacillus endocarditis.

Journal Article Ann Intern Med · December 18, 2007 BACKGROUND: Infective endocarditis caused by non-HACEK (species other than Haemophilus species, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, or Kingella species) gram-negative bacilli is rare, is poorly characterized, ... Full text Link to item Cite

The relationship between the initiation of antimicrobial therapy and the incidence of stroke in infective endocarditis: an analysis from the ICE Prospective Cohort Study (ICE-PCS).

Journal Article Am Heart J · December 2007 BACKGROUND: Embolic events to the central nervous system are a major cause of morbidity and mortality in patients with infective endocarditis (IE). The appropriate role of valvular surgery in reducing such embolic events is unclear. The purpose of this stu ... Full text Link to item Cite

Severe surgical site infection in community hospitals: epidemiology, key procedures, and the changing prevalence of methicillin-resistant Staphylococcus aureus.

Journal Article Infect Control Hosp Epidemiol · September 2007 OBJECTIVE: To characterize the epidemiology of severe (ie, nonsuperficial) surgical site infection (SSI) in community hospitals. METHODS: SSI data were collected prospectively at 26 community hospitals in the southeastern United States. Two analyses were p ... Full text Link to item Cite

Risk factors for surgical site infection complicating laminectomy.

Journal Article Infect Control Hosp Epidemiol · September 2007 OBJECTIVE: To examine risk factors for surgical site infection (SSI) following spinal surgery and to analyze the associations between a surgeon's years of operating experience and surgical specialty and patients' SSI risk. DESIGN: Case-control study. SETTI ... Full text Link to item Cite

Methicillin-resistant Staphylococcus aureus outbreak in an intensive care nursery: potential for interinstitutional spread.

Journal Article Pediatr Infect Dis J · August 2007 BACKGROUND: After surveillance surveys documented the absence of methicillin-resistant Staphylococcus aureus (MRSA) in our intensive care nursery, an outbreak of MRSA infection occurred there during a 7-month period in 2005. METHODS: Control measures inclu ... Full text Link to item Cite

Medical treatment of endocarditis.

Journal Article Curr Infect Dis Rep · July 2007 Infective endocarditis (IE) remains a serious and deadly disease. The incidence, which varies by gender and on the presence of predisposing factors, has not decreased, due in part to the aging population with more healthcare exposures and predisposing risk ... Full text Link to item Cite

Underresourced hospital infection control and prevention programs: penny wise, pound foolish?

Journal Article Infect Control Hosp Epidemiol · July 2007 OBJECTIVES: To estimate the cost of healthcare-associated infections (HAIs) in a network of 28 community hospitals and to compare this sum to the amount budgeted for infection control programs at each institution and for the entire network. DESIGN: We revi ... Full text Link to item Cite

Discovery and characterization of human antibody inhibitors of pregnancy-associated plasma protein-A.

Journal Article Biol Chem · May 2007 Pregnancy-associated plasma protein-A (PAPP-A) is a metalloprotease that cleaves insulin-like growth factor-binding proteins (IGFBPs) to release bioactive levels of free insulin-like growth factor. Specific and potent inhibitors of PAPP-A may further eluci ... Full text Link to item Cite

Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.

Journal Article J Biol Chem · April 13, 2007 ADAMTS-4 and ADAMTS-5 are aggrecanases responsible for the breakdown of cartilage aggrecan in osteoarthritis. Multiple ADAMTS-4 cleavage sites have been described in several matrix proteins including aggrecan, versican, and brevican, but no concise predict ... Full text Link to item Cite

Gram negative bloodstream infections (GN-BSI) lead to poor outcomes in older adults.

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 1, 2007 Link to item Cite

THG113.31, a specific PGF2alpha receptor antagonist, induces human myometrial relaxation and BKCa channel activation.

Journal Article Reprod Biol Endocrinol · March 16, 2007 BACKGROUND: PGF2alpha exerts a significant contractile effect on myometrium and is central to human labour. THG113.31, a specific non-competitive PGF2alpha receptor (FP) antagonist, exerts an inhibitory effect on myometrial contractility. The BKCa channel ... Full text Link to item Cite

Infection control and hospital epidemiology: A growth opportunity in medicine

Journal Article Infectious Diseases in Clinical Practice · March 1, 2007 Full text Cite

Thirty operating rules for infectious diseases apprentices

Journal Article Infectious Diseases in Clinical Practice · March 1, 2007 Like most physicians, we have developed our clinical skills by caring for patients, reading, discussing with other clinicians, and watching our mentors at work. Also, like most experienced clinicians, we rely on a relatively small number of basic rules rep ... Full text Cite

Early surgery in patients with infective endocarditis: a propensity score analysis.

Journal Article Clin Infect Dis · February 1, 2007 BACKGROUND: An accurate assessment of the predictors of long-term mortality in patients with infective endocarditis is not possible using retrospective data because of inherent treatment biases and predictable imbalances in the distribution of prognostic f ... Full text Link to item Cite

Gender differences in infective endocarditis: pre- and co-morbid conditions lead to different management and outcomes in female patients.

Journal Article Scand J Infect Dis · 2007 The impact of gender on the presenting characteristics, management, and outcomes in infective endocarditis (IE) has not been adequately studied. The goal of our study was to better understand differences in management and outcome of IE between genders. Dat ... Full text Link to item Cite

Carbapenems for surgical prophylaxis?

Journal Article N Engl J Med · December 21, 2006 Full text Link to item Cite

Spotted Fever Group Rickettsioses

Journal Article · December 1, 2006 Full text Cite

Molecular characterization of Rickettsia rickettsii infecting dogs and people in North Carolina.

Journal Article Ann N Y Acad Sci · October 2006 Rocky Mountain spotted fever (RMST) is an important cause of morbidity and mortality in people and dogs in the United States. Disease manifestations are strikingly similar in both species, and illness in dogs can precede illness in people. R. rickettsii ha ... Full text Link to item Cite

Risk factors for 1-year mortality after postoperative mediastinitis.

Journal Article J Thorac Cardiovasc Surg · September 2006 OBJECTIVE: Postoperative mediastinitis after median sternotomy is associated with disability and mortality. The aim of this study was to identify risk factors for mortality 1 year after postoperative mediastinitis diagnosis. METHODS: Postoperative mediasti ... Full text Link to item Cite

Sample preparation for MALDI mass spectrometry using an elastomeric device reversibly sealed on the MALDI target.

Journal Article Anal Chem · September 1, 2006 A new method for improving low-concentration sample recovery and reducing sample preparation steps in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) is presented. In the conventional approach, samples are typically desalted and/or ... Full text Link to item Cite

Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction.

Journal Article Reproduction · July 2006 Pre eclampsia represents a state of increased or prolonged vasoconstriction, partially linked to the potent vasocontractile effect of isoprostanes. The process of Rho A-mediated calcium sensitisation is inherent to a state of prolonged contractility in man ... Full text Link to item Cite

Acute hearing loss and rickettsial diseases.

Journal Article Clin Infect Dis · May 15, 2006 Full text Link to item Cite

High-throughput affinity ranking of antibodies using surface plasmon resonance microarrays.

Journal Article Anal Biochem · April 15, 2006 A method was developed to rapidly identify high-affinity human antibodies from phage display library selection outputs. It combines high-throughput Fab fragment expression and purification with surface plasmon resonance (SPR) microarrays to determine kinet ... Full text Link to item Cite

The epidemiology of nosocomial blood stream infection (BSI) in the elderly.

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 1, 2006 Link to item Cite

Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis--United States: a practical guide for physicians and other health-care and public health professionals.

Journal Article MMWR Recomm Rep · March 31, 2006 Tickborne rickettsial diseases (TBRD) continue to cause severe illness and death in otherwise healthy adults and children, despite the availability of low cost, effective antimicrobial therapy. The greatest challenge to clinicians is the difficult diagnost ... Link to item Cite

Rapid kinetic-based screening of human Fab fragments.

Journal Article J Immunol Methods · March 20, 2006 Human antibodies able to bind with high affinity and specificity to numerous targets have been successfully identified from Fab phage display libraries. A key step in the library selection screening process is the early characterization of library isolates ... Full text Link to item Cite

Risk factors for surgical site infections in older people.

Journal Article J Am Geriatr Soc · March 2006 OBJECTIVES: To identify risk factors for surgical site infection (SSI) in older people and to test a priori hypotheses regarding particular variables and SSI risk. DESIGN: Case-control study. SETTING: Duke University Medical Center and seven community hosp ... Full text Link to item Cite

Favorable impact of an infection control network on nosocomial infection rates in community hospitals.

Journal Article Infect Control Hosp Epidemiol · March 2006 OBJECTIVE: To describe an infection control network (the Duke Infection Control Outreach Network [DICON]) and its impact on nosocomial infection rates in community hospitals. DESIGN: Prospective cohort study of rates of nosocomial infections and exposures ... Full text Link to item Cite

Influence of diabetes mellitus on the clinical manifestations and prognosis of infective endocarditis: a report from the International Collaboration on Endocarditis-Merged Database.

Other Scand J Infect Dis · 2006 The purpose of this investigation was to study the influence of diabetes mellitus (DM) on outcomes of infective endocarditis (IE). Outcomes were compared between 150 diabetic and 905 non-diabetic patients with IE from the International Collaboration on End ... Full text Link to item Cite

Spotted Fever Group Rickettsioses

Chapter · December 21, 2005 Full text Cite

A returning traveler with fever and rash.

Journal Article Clin Infect Dis · November 15, 2005 Full text Link to item Cite

Enterococcal prosthetic valve infective endocarditis: report of 45 episodes from the International Collaboration on Endocarditis-merged database.

Journal Article Eur J Clin Microbiol Infect Dis · October 2005 Enterococcal prosthetic valve infective endocarditis (PVE) is an incompletely understood disease. In the present study, patients with enterococcal PVE were compared to patients with enterococcal native valve endocarditis (NVE) and other types of PVE to det ... Full text Link to item Cite

A distinct strategy to generate high-affinity peptide binders to receptor tyrosine kinases.

Journal Article Protein Eng Des Sel · September 2005 We describe a novel and general way of generating high affinity peptide (HAP) binders to receptor tyrosine kinases (RTKs), using a multi-step process comprising phage-display selection, identification of peptide pairs suitable for hetero-dimerization (non- ... Full text Link to item Cite

Repeat infective endocarditis: differentiating relapse from reinfection.

Journal Article Clin Infect Dis · August 1, 2005 Repeat infective endocarditis due to the same species can represent relapse of the initial infection or a new infection. We used time-based clinical criteria and pulsed-field gel electrophoresis-based molecular criteria to classify 13 cases of repeat infec ... Full text Link to item Cite

Specific PGF(2alpha) receptor (FP) antagonism and human uterine contractility in vitro.

Journal Article BJOG · August 2005 OBJECTIVE: PGF(2alpha) acts through its receptor, FP, as an important smooth muscle contractile agent. The aim of this study was to investigate the effects of specific FP antagonism, using the novel-specific FP non-competitive antagonist THG113.31, on spon ... Full text Link to item Cite

Enterococcal endocarditis: 107 cases from the international collaboration on endocarditis merged database.

Journal Article Am J Med · July 2005 PURPOSE: To describe clinical features and outcomes of enterococcal left-sided native valve endocarditis and to compare it to endocarditis caused by other pathogens. SUBJECTS AND METHODS: Patients in the International Collaboration on Endocarditis-Merged D ... Full text Link to item Cite

The effect of increasing age on the risk of surgical site infection.

Journal Article J Infect Dis · April 1, 2005 BACKGROUND: An increasing number of older persons undergo surgery, but the relationship between increasing age and risk of surgical site infection (SSI) has not been established. The objective of the present study was to determine the relationship between ... Full text Link to item Cite

Risk of endocarditis among patients with prosthetic valves and Staphylococcus aureus bacteremia.

Journal Article Am J Med · March 2005 PURPOSE: Staphylococcus aureus is a common cause of bacteremia and of native valve infective endocarditis. However, the risk of endocarditis in patients with a prosthetic valve who develop S. aureus bacteremia is unclear. The aim of this study was to defin ... Full text Link to item Cite

Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity.

Journal Article Nat Biotechnol · March 2005 Combinatorial libraries of rearranged hypervariable V(H) and V(L) sequences from nonimmunized human donors contain antigen specificities, including anti-self reactivities, created by random pairing of V(H)s and V(L)s. Somatic hypermutation of immunoglobuli ... Full text Link to item Cite

Aortic coarctation endarteritis in an adult: case report with cardiovascular magnetic resonance imaging findings and review of the literature.

Journal Article Clin Infect Dis · February 15, 2005 We describe a case of coarctation endarteritis in an adult and review the literature pertaining to this condition. Adult coarctation endarteritis is a rare entity but often represents the initial presentation of coarctation. Diagnosis is critically importa ... Full text Link to item Cite

Risk factors for ineffective therapy in patients with bloodstream infection.

Journal Article Arch Intern Med · February 14, 2005 BACKGROUND: Infections occurring among outpatients having recent contact with the health care system have been termed health care-associated infections. The objective of this study was to analyze the impact of health care-associated status on effectiveness ... Full text Link to item Cite

Discovery of high-affinity peptide binders to BLyS by phage display.

Journal Article J Mol Recognit · 2005 B lymphocyte stimulator (BLyS) is a tumor necrosis factor (TNF) family member and a key regulator of B cell responses. We employed a phage display-based approach to identify peptides that bind BLyS with high selectivity and affinity. Sequence analysis of f ... Full text Link to item Cite

Making a home in the community for the academic medical center.

Journal Article Acad Med · January 2005 Academic medical centers (AMCs) have traditionally provided primary care for low-income and other underserved populations. However, they have had difficulty developing lasting partnerships with other organizations serving the same populations. This article ... Full text Link to item Cite

Functional effects of 17alpha-hydroxyprogesterone caproate (17P) on human myometrial contractility in vitro.

Journal Article Reprod Biol Endocrinol · December 7, 2004 BACKGROUND: 17 alpha-hydroxyprogesterone caproate (17P) administration reportedly improves outcome for women with a previous spontaneous preterm delivery. This study, using in vitro strips of human uterine smooth muscle, aimed to investigate the direct non ... Full text Link to item Cite

Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries.

Journal Article J Immunol Methods · June 2004 We introduce a procedure for the rapid generation of fully human antibodies derived from "Fab-on-phage" display libraries. The technology is based on the compatibility of display vectors and IgG expression constructs, and allows reformatting of individual ... Full text Link to item Cite

Surgical-site infection due to Staphylococcus aureus among elderly patients: mortality, duration of hospitalization, and cost.

Journal Article Infect Control Hosp Epidemiol · June 2004 OBJECTIVES: To examine the impact of surgical-site infection (SSI) due to Staphylococcus aureus on mortality, duration of hospitalization, and hospital charges among elderly surgical patients and the impact of older age on these outcomes by comparing older ... Full text Link to item Cite

Risk factors for postoperative mediastinitis due to methicillin-resistant Staphylococcus aureus.

Journal Article Clin Infect Dis · June 1, 2004 Risk factors for developing postoperative mediastinitis (POM) due to methicillin-resistant Staphylococcus aureus (MRSA) were analyzed in a case-case control study of patients who underwent median sternotomy during the period from 1994 through 2000. Three p ... Full text Link to item Cite

Early predictors of in-hospital death in infective endocarditis.

Journal Article Circulation · April 13, 2004 BACKGROUND: Data on early determinants of outcome in infective endocarditis (IE) are limited. We evaluated the prognostic significance of early clinical characteristics in a large, prospective cohort of patients with IE. METHODS AND RESULTS: Two hundred si ... Full text Link to item Cite

Risk factors for infective endocarditis in patients with enterococcal bacteremia: a case-control study.

Journal Article Infection · April 2004 BACKGROUND: Based on previous studies, enterococcal infective endocarditis (IE) is considered a unimicrobial, community-acquired disease of older Caucasian men. PATIENTS AND METHODS: We evaluated the relationship between enterococcal bacteremia and IE by c ... Full text Link to item Cite

Stroke location, characterization, severity, and outcome in mitral vs aortic valve endocarditis.

Journal Article Neurology · November 25, 2003 OBJECTIVE: To characterize the incidence and clinical features of patients with infective endocarditis (IE) and stroke. METHODS: The authors reviewed the records of 707 patients diagnosed with definite or possible IE between January 1984 and November 1999. ... Full text Link to item Cite

Elevated preoperative fasting serum glucose levels increase the risk of postoperative mediastinitis in patients undergoing open heart surgery.

Journal Article Infect Control Hosp Epidemiol · October 2003 We conducted a case-control study to investigate the relationship between preoperative fasting serum glucose and postoperative mediastinitis in patients undergoing open heart surgery. Multivariate analysis revealed that a glucose level of 126 mg/dL or grea ... Full text Link to item Cite

Staphylococcus aureus pericardial abscess in a patient with liver cirrhosis: case report.

Journal Article South Med J · September 2003 Pericardial abscess is a rare complication of Staphylococcus aureus bacteremia. We report the case of a 40-year-old man with hepatitis C and liver cirrhosis who presented with high-grade fever and chest pain. Transthoracic echocardiography showed a pericar ... Full text Link to item Cite

Health Care–Associated Bloodstream Infections

Journal Article Annals of Internal Medicine · August 5, 2003 Full text Cite

Health care--associated bloodstream infections.

Journal Article Ann Intern Med · August 5, 2003 Full text Link to item Cite

Staphylococcus aureus bacteremia after median sternotomy: clinical utility of blood culture results in the identification of postoperative mediastinitis.

Journal Article Circulation · July 8, 2003 BACKGROUND: Mediastinitis is a complication of coronary artery bypass graft surgery (CABG) that can be difficult to diagnose. This study evaluated the utility of blood culture results in identifying patients with mediastinitis. METHODS AND RESULTS: All uni ... Full text Link to item Cite

Novel peptide inhibitors of angiotensin-converting enzyme 2.

Journal Article J Biol Chem · May 2, 2003 Angiotensin-converting enzyme 2 (ACE2), a recently identified human homolog of ACE, is a novel metallocarboxypeptidase with specificity, tissue distribution, and function distinct from those of ACE. ACE2 may play a unique role in the renin-angiotensin syst ... Full text Link to item Cite

Current best practices and guidelines. Assessment and management of complications in infective endocarditis.

Journal Article Cardiol Clin · May 2003 The most important complications of endocarditis are congestive heart failure, paravalvular abscess formation, and embolism, especially stroke. In addition, endocarditis may be complicated by septic arthritis, vertebral osteomyelitis, pericarditis, metasta ... Full text Link to item Cite

The value of an infectious diseases specialist.

Journal Article Clin Infect Dis · April 15, 2003 Infectious diseases (ID) specialists have played a major role in patient care, infection control, and antibiotic management for many years. With the rapidly changing nature of health care, it has become necessary for ID specialists to articulate their valu ... Full text Link to item Cite

Risk factors for pediatric ventriculoperitoneal shunt infection and predictors of infectious pathogens.

Journal Article Clin Infect Dis · April 1, 2003 Identification of risk factors for shunt infection and predictors of infectious pathogens may improve current methods to prevent and treat shunt infections. We reviewed data on 820 consecutive ventriculoperitoneal (VP) shunt placement procedures in 442 ped ... Full text Link to item Cite

Efficacy of permethrin-treated bed nets in the prevention of mortality in young children in an area of high perennial malaria transmission in western Kenya.

Journal Article Am J Trop Med Hyg · April 2003 A group-randomized controlled trial of insecticide (permethrin)-treated bed nets (ITNs) was conducted in an area of high perennial malaria transmission in western Kenya to test the effect of ITNs on all-cause mortality in children 1-59 months of age. Child ... Link to item Cite

Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection.

Journal Article Clin Infect Dis · March 1, 2003 Data for 479 patients were analyzed to assess the impact of methicillin resistance on the outcomes of patients with Staphylococcus aureus surgical site infections (SSIs). Patients infected with methicillin-resistant S. aureus (MRSA) had a greater 90-day mo ... Full text Link to item Cite

Health care--associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections.

Journal Article Ann Intern Med · November 19, 2002 BACKGROUND: Bloodstream infections occurring in persons residing in the community, regardless of whether those persons have been receiving health care in an outpatient facility, have traditionally been categorized as community-acquired infections. OBJECTIV ... Full text Link to item Cite

Rickettsialpox in North Carolina: a case report.

Journal Article Emerg Infect Dis · July 2002 We report a case of rickettsialpox from North Carolina confirmed by serologic testing. To our knowledge, this case is the first to be reported from this region of the United States. Including rickettsialpox in the evaluation of patients with eschars or ves ... Full text Link to item Cite

Current best practices and guidelines. Assessment and management of complications in infective endocarditis.

Journal Article Infect Dis Clin North Am · June 2002 The most important complications of endocarditis are congestive heart failure, paravalvular abscess formation, and embolism, especially stroke. In addition, endocarditis may be complicated by septic arthritis, vertebral osteomyelitis, pericarditis, metasta ... Full text Link to item Cite

Acute terminal ileitis associated with pneumococcal bacteremia: case report and review of pneumococcal gastrointestinal diseases.

Journal Article Clin Infect Dis · May 15, 2002 In this report, we describe a patient with acute terminal ileitis due to Streptococcus pneumoniae, review 3 previously reported cases of isolated enteritis due to S. pneumoniae, and summarize the English-language literature on primary and secondary pneumoc ... Full text Link to item Cite

The impact of surgical-site infections following orthopedic surgery at a community hospital and a university hospital: adverse quality of life, excess length of stay, and extra cost.

Journal Article Infect Control Hosp Epidemiol · April 2002 OBJECTIVE: To measure the impact of orthopedic surgical-site infections (SSIs) on quality of life, length of hospitalization, and cost. DESIGN: A pairwise-matched (1:1) case-control study within a cohort. SETTING: A tertiary-care university medical center ... Full text Link to item Cite

Rocky mountain spotted fever.

Journal Article Med Clin North Am · March 2002 Rocky mountain spotted fever (RMSF) is a fulminant tick-borne infection by Rickettsia rickettsii. The classical diagnostic triad is fever, headache and rash in a patient with a recent tick bite. With prompt, appropriate antimicrobial therapy, patient outco ... Full text Link to item Cite

Postoperative bacteremia secondary to surgical site infection.

Journal Article Clin Infect Dis · February 1, 2002 We evaluated all surgical site infections (SSI) and postoperative bacteremias secondary to SSI as part of an ongoing active surgical surveillance program at a community hospital. Among 40,191 surgical procedures, we identified 515 patients with SSI and 47 ... Full text Link to item Cite

Changing patient characteristics and the effect on mortality in endocarditis.

Journal Article Arch Intern Med · January 14, 2002 BACKGROUND: Limited data exist on recent demographic and microbiological changes in infective endocarditis (IE) and the impact of these changes on patient survival. METHODS: Data were collected from all patients with definite or possible IE at Duke Univers ... Full text Link to item Cite

Development of mammalian serum albumin affinity purification media by peptide phage display.

Journal Article Biotechnol Prog · 2002 Several phage isolates that bind specifically to human serum albumin (HSA) were isolated from disulfide-constrained cyclic peptide phage-display libraries. The majority of corresponding synthetic peptides bind with micromolar affinity to HSA in low salt at ... Full text Link to item Cite

Glove use versus hand washing to prevent hospital-acquired infection

Journal Article Journal of Critical Illness · January 1, 2002 Cite

Vascular access infections in patients undergoing dialysis with special emphasis on the role and treatment of Staphylococcus aureus.

Journal Article Infect Dis Clin North Am · September 2001 Access-related infections are the most important causes of the loss of vascular access for dialysis. These infections also may lead to devastating consequences, including sepsis with multiorgan failure; endocarditis; or metastatic infections such as verteb ... Full text Link to item Cite

Cardiac conduction abnormalities in endocarditis defined by the Duke criteria.

Journal Article Am Heart J · August 2001 BACKGROUND: Cardiac conduction abnormalities occur in endocarditis and have been associated with infection extension and increased mortality. There have been no prospective studies of electrocardiographic (ECG) conduction changes in endocarditis. We examin ... Full text Link to item Cite

The risk of stroke and death in patients with aortic and mitral valve endocarditis.

Journal Article Am Heart J · July 2001 BACKGROUND: Previous studies have generated inconsistent results when attempting to define predictors of stroke and death in patients with endocarditis. We sought to examine the relationship between vegetation 2-dimensional size and stroke in those with in ... Full text Link to item Cite

The effects of intravenous doxycycline therapy for rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial.

Journal Article Arthritis Rheum · May 2001 OBJECTIVE: To determine the feasibility, safety, and potential clinical efficacy of intravenous (IV) doxycycline therapy for rheumatoid arthritis (RA), as well as its possible effects on serum and urinary markers of collagen breakdown. METHODS: The explora ... Full text Link to item Cite

Cardiac conduction abnormalites complicating infective endocarditis

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 2001 Link to item Cite

The effect of changing trends in endocarditis on outcomes

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 2001 Link to item Cite

Bursitis due to Mycobacterium goodii, a recently described, rapidly growing mycobacterium.

Journal Article J Clin Microbiol · January 2001 We report a case of olecranon bursitis due to Mycobacterium goodii in a 60-year-old man. Prior to recognition of his infection, he received intrabursal steroids and underwent olecranon bursectomy. His infection was cured with antimicrobial therapy consisti ... Full text Link to item Cite

Findings of the 1998 Infectious Diseases Society of America membership survey.

Journal Article Clin Infect Dis · December 2000 The Infectious Diseases Society of America (IDSA) conducted a survey in 1998 to characterize its membership and to determine their needs. The response rate was 39%. Although only 23% of the respondents spent most of their time in the field of teaching and ... Full text Link to item Cite

A pseudo-outbreak of Aureobasidium species lower respiratory tract infections caused by reuse of single-use stopcocks during bronchoscopy.

Journal Article Infect Control Hosp Epidemiol · July 2000 OBJECTIVE: To investigate and control an apparent outbreak of lower respiratory tract infections due to Aureobasidium species. DESIGN: Outbreak investigation. SETTING: University-affiliated medical center. PATIENTS: Nine patients who underwent bronchoscopy ... Full text Link to item Cite

Clinical information determines the impact of transesophageal echocardiography on the diagnosis of infective endocarditis by the duke criteria.

Journal Article Am Heart J · June 2000 BACKGROUND: Although transesophageal echocardiography (TEE) is more sensitive than transthoracic echocardiography (TTE) in detecting echocardiographic evidence of infective endocarditis (IE), the impact of TEE on the clinical diagnosis of IE has not been c ... Full text Link to item Cite

Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis.

Journal Article Clin Infect Dis · April 2000 Although the sensitivity and specificity of the Duke criteria for the diagnosis of infective endocarditis (IE) have been validated by investigators from Europe and the United States, several shortcomings of this schema remain. The Duke IE database contains ... Full text Link to item Cite

Prospective analysis of Staphylococcus aureus bacteremia in nonneutropenic adults with malignancy.

Journal Article J Clin Oncol · March 2000 PURPOSE: To determine the primary sources and secondary complications of Staphylococcus aureus bacteremia (SAB) in cancer patients, as well as predictors of outcome in cancer patients with SAB. PATIENTS AND METHODS: Fifty-two patients at Duke University Me ... Full text Link to item Cite

Staphylococcus aureus bacteremia in the surgical patient: a prospective analysis of 73 postoperative patients who developed Staphylococcus aureus bacteremia at a tertiary care facility.

Journal Article J Am Coll Surg · January 2000 BACKGROUND: Staphylococcus aureus is a frequent cause of infection and bacteremia in the postoperative patient. Unfortunately, there have been no prospective studies evaluating these patients, so the incidence of complications, subsequent treatment algorit ... Full text Link to item Cite

The impact of antimicrobial resistance on empiric antibiotic selection and antimicrobial use in clinical practice.

Journal Article J Med Liban · 2000 The prevalence of antimicrobial resistance may vary dramatically between countries and regions and even among different patient populations and between hospitals in the same community. In light of these variations, physicians in practice must make a clinic ... Link to item Cite

The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs.

Journal Article Infect Control Hosp Epidemiol · November 1999 OBJECTIVE: To determine mortality, morbidity, and costs attributable to surgical-site infections (SSIs) in the 1990s. DESIGN: A matched follow-up study of a cohort of patients with SSI, matched one-to-one with patients without SSI. SETTING: A 415-bed commu ... Full text Link to item Cite

Nosocomial fever of unknown origin

Journal Article Infectious Diseases in Clinical Practice · November 1, 1999 This study described the demographics, etiology, and prognosis of nosocomial fever of unknown origin (FUO) using a retrospective study design. The study sites included a university-controlled, tertiary referral teaching hospital, a university-associated Ve ... Full text Cite

The incidence of ehrlichial and rickettsial infection in patients with unexplained fever and recent history of tick bite in central North Carolina.

Journal Article J Infect Dis · September 1999 We examined the clinical and laboratory findings of a consecutive series of patients from central North Carolina presenting with fever and a history of tick bite within the preceding 14 days. Evidence of a tick-transmitted pathogen was detected in 16 of 35 ... Full text Link to item Cite

Sliding clamp of the bacteriophage T4 polymerase has open and closed subunit interfaces in solution.

Journal Article Biochemistry · June 15, 1999 The sliding clamps of bacteriophage T4 (gp45), Escherichia coli (beta clamp), and yeast (PCNA) are required for processive DNA synthesis by their cognate DNA polymerases. The X-ray crystal structures of all three of these clamps have been shown to be close ... Full text Link to item Cite

Staphylococcus aureus bacteremia among elderly vs younger adult patients: comparison of clinical features and mortality.

Journal Article Arch Intern Med · June 14, 1999 BACKGROUND: Previous studies give conflicting results regarding the effect of age on outcomes in Staphylococcus aureus bacteremia (SAB). These studies have been limited by retrospective design or small sample size. METHODS: We conducted a prospective cohor ... Full text Link to item Cite

Nosocomial methicillin-resistant and methicillin-susceptible Staphylococcus aureus primary bacteremia: at what costs?

Journal Article Infect Control Hosp Epidemiol · June 1999 OBJECTIVE: To determine the attributable hospital stay and costs for nosocomial methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) primary bloodstream infections (BSIs). DESIGN: Pairwise-matched (1:1) nested case- ... Full text Link to item Cite

Imported African tick bite fever: a case report.

Journal Article Am J Trop Med Hyg · May 1999 We describe a patient with African tick-bite fever who acquired his infection while visiting rural areas of South Africa and then became sick after returning to the United States. The dominant clinical feature of his illness was the presence of multiple, u ... Full text Link to item Cite

Recurrent Staphylococcus aureus bacteremia: pulsed-field gel electrophoresis findings in 29 patients.

Journal Article J Infect Dis · May 1999 To identify risk factors for relapse among 309 prospectively identified cases of Staphylococcus aureus bacteremia, patients with recurrent S. aureus bacteremia were identified, and pulsed-field gel electrophoresis (PFGE) was performed on isolates from both ... Full text Link to item Cite

Infective endocarditis due to Staphylococcus aureus: 59 prospectively identified cases with follow-up.

Journal Article Clin Infect Dis · January 1999 Fifty-nine consecutive patients with definite Staphylococcus aureus infective endocarditis (IE) by the Duke criteria were prospectively identified at our hospital over a 3-year period. Twenty-seven (45.8%) of the 59 patients had hospital-acquired S. aureus ... Full text Link to item Cite

Septic arthritis

Journal Article Infectious Diseases in Clinical Practice · January 1, 1999 Full text Cite

Primary care of HIV infection.

Journal Article Hosp Pract (1995) · December 15, 1998 Four cases illustrate some of the issues involved in treating HIV-infected patients in a primary care setting. Primary care physicians are hard-pressed to achieve the same results as infectious disease specialists, yet are increasingly responsible for perf ... Full text Link to item Cite

Ceftriaxone once daily for four weeks compared with ceftriaxone plus gentamicin once daily for two weeks for treatment of endocarditis due to penicillin-susceptible streptococci. Endocarditis Treatment Consortium Group.

Journal Article Clin Infect Dis · December 1998 This randomized, multicenter, open-label study compared the efficacy and safety of monotherapy with 2 g of intravenous ceftriaxone once daily for 4 weeks with those of combination therapy with 2 g of intravenous ceftriaxone and 3 mg of intravenous gentamic ... Full text Link to item Cite

Incidence and outcome of Staphylococcus aureus bacteremia in hemodialysis patients.

Journal Article Kidney Int · November 1998 BACKGROUND: Staphylococcus aureus bacteremia is frequently associated with metastatic complications and infective endocarditis (IE). The Duke criteria for the diagnosis of IE utilize echocardiographic techniques and are more sensitive than previous criteri ... Full text Link to item Cite

Outcome of Staphylococcus aureus bacteremia according to compliance with recommendations of infectious diseases specialists: experience with 244 patients.

Journal Article Clin Infect Dis · September 1998 To determine whether recommendations of infectious diseases specialists affect outcome for patients, we evaluated 244 hospitalized patients with Staphylococcus aureus bacteremia. We offered our management recommendations to each patient's physicians and th ... Full text Link to item Cite

S-nitrosoglutathione/glutathione disulphide/Cu2+-dependent stimulation of L-arginine transport in human platelets.

Journal Article Thromb Res · August 1, 1998 In this study, we have examined the effects of authentic nitric oxide (NO), NO+ (NOBF4), glutathione (GSH), glutathione disulphide (GSSG), and S-nitrosoglutathione (GSNO) in the presence and absence of Cu2+, which thermally releases NO from S-nitrosothiols ... Full text Link to item Cite

Reply

Journal Article Clinical Infectious Diseases · August 1998 Full text Cite

Reply

Journal Article Clinical Infectious Diseases · July 1998 Full text Cite

Dissecting the order of bacteriophage T4 DNA polymerase holoenzyme assembly.

Journal Article Biochemistry · May 26, 1998 Most biological organisms rely upon a DNA polymerase holoenzyme for processive DNA replication. The bacteriophage T4 DNA polymerase holoenzyme is composed of the polymerase enzyme and a clamp protein (the 45 protein), which functions as a processivity fact ... Full text Link to item Cite

Native valve infective endocarditis in elderly and younger adult patients: comparison of clinical features and outcomes with use of the Duke criteria and the Duke Endocarditis Database.

Journal Article Clin Infect Dis · May 1998 The effect of age on the presentation and outcome of infective endocarditis (IE) is unclear. Many of the available data are based on analyses of mixed populations of patients including intravenous drug users or those with prosthetic valve endocarditis or n ... Full text Link to item Cite

Catheter-Related Bacteremia in Patients Undergoing Hemodialysis

Journal Article Annals of Internal Medicine · April 1, 1998 Full text Cite

Clamp subunit dissociation dictates bacteriophage T4 DNA polymerase holoenzyme disassembly.

Journal Article Biochemistry · February 17, 1998 Clamp proteins confer processivity to the DNA polymerase during DNA replication. These oligomeric proteins are loaded onto DNA by clamp loader protein complexes in an ATP-dependent manner. The mechanism by which the trimeric bacteriophage T4 clamp protein ... Full text Link to item Cite

Infection control: past, present, and future issues.

Journal Article Compr Ther · February 1998 Primary care providers serve as role models for the prevention of nosocomial infections through membership on hospital infection-control committees and daily patient care. This article will review five fundamental infection control measures: surveillance, ... Link to item Cite

Predictors of prognosis and risk of acute renal failure in bacterial endocarditis.

Journal Article Clin Nephrol · February 1998 BACKGROUND: The epidemiology, criteria for diagnosis and treatment of bacterial endocarditis has changed substantially in the past 2 decades, yet little attention has been given to the changing etiologies of renal insufficiency and the predictors of renal ... Link to item Cite

Prospective Study of Clinical Outcome in Endocarditis Patients

Journal Article Journal of the American College of Cardiology · February 1998 Full text Cite

Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report.

Journal Article Emerg Infect Dis · 1998 Well-documented cases of simultaneous human infection with more than one tick-borne pathogen are rare. To our knowledge only two dual infections have been reported: simultaneous human infection with the agent of human granulocytic ehrlichiosis and Borrelia ... Full text Open Access Link to item Cite

An evaluation of the Duke criteria in 25 pathologically confirmed cases of prosthetic valve endocarditis.

Journal Article Clin Infect Dis · December 1997 Six studies have compared the sensitivity of the Duke criteria with that of the Beth Israel criteria for the diagnosis of infective endocarditis without attempting to distinguish between native valve and prosthetic valve cases. After reviewing clinical dat ... Full text Link to item Cite

Outcome of Staphylococcus aureus Bacteremia according to compliance with infectious diseases specialist recommendations: experience with 253 patients

Journal Article Clinical Infectious Diseases · December 1, 1997 The impact of infectious disease specialist involvement on the clinical outcome of hospitalized patients has been inadequately studied. To determine whether recommendations of infectious disease specialists affect the clinical outcome of hospitalized patie ... Cite

Staphylococcus aureus bacteremia: A treatment algorithm

Journal Article Clinical Infectious Diseases · December 1, 1997 An algorithm to define the duration of therapy for patients with Staphylococcus aureus bacteremia was prospectively tested. Recommendations for all patients with SAB were as follows: all removable foci of infection should be removed, surveillance blood cul ... Cite

Dissociation of bacteriophage T4 DNA polymerase and its processivity clamp after completion of Okazaki fragment synthesis.

Journal Article Biochemistry · November 25, 1997 The mechanism of bacteriophage T4 DNA polymerase (gp43) and clamp (gp45) protein dissociation from the holoenzyme DNA complex was investigated under conditions simulating the environment encountered upon completion of an Okazaki fragment. Lagging strand DN ... Full text Link to item Cite

Bacterial endocarditis in hemodialysis patients.

Journal Article Am J Kidney Dis · October 1997 Infective endocarditis (IE) is one of the most serious complications of bacteremia. Hemodialysis patients with prosthetic vascular access devices such as dual-lumen cuffed venous catheters and polytetrafluoroethylene (PTFE) grafts are at increased risk for ... Full text Link to item Cite

Role of echocardiography in evaluation of patients with Staphylococcus aureus bacteremia: experience in 103 patients.

Journal Article J Am Coll Cardiol · October 1997 OBJECTIVES: The purpose of this prospective study was to examine the role of echocardiography in patients with Staphylococcus aureus bacteremia (SAB). BACKGROUND: The reported incidence of infective endocarditis (IE) among patients with SAB varies widely. ... Full text Link to item Cite

Assembly and disassembly of DNA polymerase holoenzyme.

Journal Article Curr Opin Chem Biol · October 1997 The complex task of genomic replication requires a large collection of proteins properly assembled within the close confines of the replication fork. The mechanism and dynamics of holoenzyme assembly and disassembly have been investigated using steady stat ... Full text Link to item Cite

The great imitator: Rocky Mountain spotted fever occurring after hospitalization for unrelated illnesses.

Journal Article South Med J · September 1997 We describe two patients who had Rocky Mountain spotted fever after they were admitted to the hospital for emergency and elective surgical procedures. We initially thought one patient had a hospital-acquired infection; the correct diagnosis was deduced fro ... Full text Link to item Cite

Catheter-related bacteremia and outcome of attempted catheter salvage in patients undergoing hemodialysis.

Journal Article Ann Intern Med · August 15, 1997 BACKGROUND: Dual-lumen cuffed catheters are used for vascular access in patients undergoing hemodialysis. The incidence and appropriate management of catheter-related bacteremia are unknown. OBJECTIVE: To determine the incidence and outcome of catheter-rel ... Full text Link to item Cite

Seroepidemiology of Rickettsia typhi, spotted fever group rickettsiae, and Coxiella burnetti infection in pregnant women from urban Tanzania.

Journal Article Am J Trop Med Hyg · August 1997 Immunofluorescent antibody (IFA) testing was performed on sera drawn from 150 pregnant women in the port city of Dar es Salaam, Tanzania. Prevalence of antibodies to Rickettsia typhi was 28%, higher than in any of the 12 other African countries in which se ... Full text Link to item Cite

Immunoperoxidase and immunofluorescent staining of Rickettsia rickettsii in skin biopsies. A comparative study.

Journal Article Arch Pathol Lab Med · August 1997 OBJECTIVE: To compare immunofluorescent and immunoperoxidase staining of Rickettsia rickettsii in skin biopsies of patients suspected of having Rocky Mountain spotted fever (RMSF). DESIGN: Immunofluorescent staining results for R rickettsii from skin biops ... Link to item Cite

Life-threatening Cache Valley virus infection.

Journal Article N Engl J Med · February 20, 1997 Full text Link to item Cite

Hospital pharmacists and infectious diseases specialists

Journal Article Clinical Infectious Diseases · January 1, 1997 Full text Cite

Predictors of prognosis and risk of acute renal failure in patients with Rocky Mountain spotted fever.

Journal Article Am J Med · December 1996 BACKGROUND: Acute renal failure has long been associated with severe Rocky Mountain spotted fever (RMSF). Despite many descriptions of the protean manifestations of this disease, relatively little is known concerning the risk factors for acute renal failur ... Full text Link to item Cite

Protein-protein and protein-DNA interactions at the bacteriophage T4 DNA replication fork. Characterization of a fluorescently labeled DNA polymerase sliding clamp.

Journal Article J Biol Chem · November 8, 1996 The T4 DNA polymerase holoenzyme is composed of the polymerase enzyme complexed to the sliding clamp (the 45 protein), which is loaded onto DNA by an ATP-dependent clamp loader (the 44/62 complex). This paper describes a new method to directly investigate ... Full text Link to item Cite

Predictors of prognosis and risk of acute renal failure in Rocky Mountain spotted fever.

Journal Article JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY · September 1, 1996 Link to item Cite

Reply

Journal Article Clinical Infectious Diseases · July 1, 1996 Full text Cite

Monitoring community response to malaria control using insecticide-impregnated bed nets, curtains and residual spray at Nsukka, Nigeria.

Journal Article Health Educ Res · June 1996 A project testing the efficacy of insecticide (permethrin)-impregnated bed nets, compared with impregnated door and window curtains, residual house spraying, and a control group was implemented in 12 village clusters in the Nsukka Local Government Area of ... Full text Link to item Cite

Negative predictive value of the Duke criteria for infective endocarditis.

Journal Article Am J Cardiol · February 15, 1996 With use of new Duke criteria, 405 episodes of suspected endocarditis were previously classified as "definite," "possible," or "rejected" endocarditis. To determine the negative predictive value of the Duke clinical criteria for the classification of suspe ... Full text Link to item Cite

Periprosthetic infections due to Mycobacterium tuberculosis in patients with no prior history of tuberculosis.

Journal Article J Arthroplasty · February 1996 Although uncommon, infection of prostheses with Mycobacterium tuberculosis can be managed successfully if it is diagnosed early and treated correctly. A case of M. tuberculosis infection of a prosthetic knee first diagnosed 4.5 years after initial arthropl ... Full text Link to item Cite

Resistant enterococci: a prospective study of prevalence, incidence, and factors associated with colonization in a university hospital.

Journal Article Infect Control Hosp Epidemiol · January 1996 OBJECTIVE: To determine the prevalence of gastrointestinal tract colonization with antibiotic-resistant enterococci at ward entry and to study the incidence and risk factors for nosocomial acquisition of colonization with resistant enterococci. DESIGN: A p ... Full text Link to item Cite

Rocky Mountain spotted fever presenting with acute monarticular arthritis.

Journal Article Arthritis Rheum · January 1996 This report describes a 30-year-old man who presented with an acute multisystem illness which was diagnosed as Rocky Mountain spotted fever (RMSF). Near the time of admission the patient was noted to have a newly developed aseptic monarticular arthritis of ... Full text Link to item Cite

Prolonged Bartonella bacteremia in cats associated with cat-scratch disease patients.

Journal Article J Clin Microbiol · December 1995 Recent evidence supports a causal relationship between Bartonella (Rochalimaea) henselae, cat-scratch disease (CSD), and bacillary angiomatosis. Cats appear to be the primary reservoir. Blood from 19 cats owned by 14 patients diagnosed with CSD was culture ... Full text Link to item Cite

Mediastinitis after coronary artery bypass graft surgery. Risk factors and long-term survival.

Journal Article Circulation · October 15, 1995 BACKGROUND: Mediastinitis is a severe complication of coronary artery bypass graft surgery (CABG). The purpose of the present study was to determine preoperative and intraoperative variables that predict mediastinitis and to determine the impact of this co ... Full text Link to item Cite

Photo quiz. Murine typhus (Rickettsia typhi).

Journal Article Clin Infect Dis · October 1995 Link to item Cite

MURINE TYPHUS (RICKETTSIA-TYPHI)

Journal Article CLINICAL INFECTIOUS DISEASES · October 1, 1995 Link to item Cite

Photo quiz. Rocky Mountain Spotted Fever.

Journal Article Clin Infect Dis · August 1995 Link to item Cite

Long-term sequelae of Rocky Mountain spotted fever.

Journal Article Clin Infect Dis · May 1995 Twenty-five patients with definite or probable Rocky Mountain spotted fever (RMSF) who were hospitalized for > or = 2 weeks were identified from our database of 105 patients. Follow-up information was collected for 20 patients, per telephone and/or medical ... Full text Link to item Cite

Therapeutic delay and mortality in cases of Rocky Mountain spotted fever.

Journal Article Clin Infect Dis · May 1995 We conducted a retrospective cohort study of patients with Rocky Mountain spotted fever (RMSF) at a university hospital in order to assess the relationship between delay in treatment and mortality and to identify predictors of delay in initiating therapy. ... Full text Link to item Cite

The effectiveness of insecticide-impregnated bed nets in reducing cases of malaria infection: a meta-analysis of published results.

Journal Article Am J Trop Med Hyg · May 1995 The use of insecticide-impregnated bed nets to minimize human-vector contact may reduce the incidence of malaria. Consequently, several field trials have evaluated their effectiveness as a malaria prevention strategy. A meta-analysis of published reports o ... Full text Link to item Cite

Consultation in university-based and community-based infectious disease practices: a prospective study.

Journal Article Clin Infect Dis · February 1995 Infectious disease physicians in university and community practices completed a standard data form following each of 1,366 inpatient consultations during a 7-month period. The rate of consultation was higher in the university practice than in the community ... Full text Link to item Cite

Answer to photo quiz (see page 315)

Journal Article Clinical Infectious Diseases · January 1, 1995 Full text Cite

Answer to photo quiz

Journal Article Clinical Infectious Diseases · January 1, 1995 Full text Cite

Mycobacterium avium intracellulare infection.

Journal Article J Bone Joint Surg Br · January 1995 Link to item Cite

Platelet glutathione transport: characteristics and evidence for regulation by intraplatelet thiol status.

Journal Article Biochem Cell Biol · 1995 The present study demonstrates the carrier-mediated uptake of intact glutathione (GSH) by human platelets. Platelet GSH uptake was characterized as being Na+ independent and saturable. The KM, apparent and Vmax, apparent for GSH uptake in platelet plasma m ... Full text Link to item Cite

Photo quiz

Journal Article Clinical Infectious Diseases · January 1, 1995 Full text Cite

Photo quiz

Journal Article Clinical Infectious Diseases · January 1, 1995 Full text Cite

MYCOBACTERIUM-AVIUM-INTRACELLULARE INFECTION

Journal Article JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME · January 1, 1995 Link to item Cite

Mycoplasma hominis septic arthritis: two case reports and review.

Journal Article Clin Infect Dis · December 1994 Mycoplasma hominis is normally a commensal of humans. When the organism is pathogenic, it primarily causes disease in the genitourinary tract. Septic arthritis caused by M. hominis is a rare condition that occurs chiefly in the postpartum period, in immuno ... Full text Link to item Cite

Pott's disease caused by Mycobacterium xenopi: case report and review.

Journal Article Clin Infect Dis · December 1994 We report a case of Mycobacterium xenopi infection of the spine in a 70-year-old woman. The findings of our case and of five other published reports of bone or joint infection with M. xenopi illustrate the problems with diagnosis and management of infectio ... Full text Link to item Cite

Necrotizing fasciitis and myositis caused by group A streptococci. Epidemiology, diagnosis, and treatment of "flesh-eating bacteria".

Journal Article N C Med J · October 1994 Despite the absence of conclusive proof, the incidence of necrotizing fasciitis and myositis due to GAS may be increasing, possibly related to shifts in the proportion of GAS isolates of M-Types 1 and 3. These M-types (or the production of exotoxins and pr ... Link to item Cite

Dermatologic manifestations of arthropod-borne diseases.

Journal Article Infect Dis Clin North Am · September 1994 The arthropod-borne rickettsial, borrelial, and bacterial diseases of North America are a diverse group of disorders that produce a wide variety of cutaneous abnormalities. These dermatologic abnormalities are often valuable clinical clues that may reveal ... Link to item Cite

Effects of permethrin-impregnated bed nets on malaria vectors of northern Guatemala.

Journal Article Bull Pan Am Health Organ · June 1994 The authors evaluated the effects on malaria vectors of bed nets impregnated with permethrin over the course of a 16-month controlled study in four communities of Northern Guatemala. Anopheles albimanus and An. vestitipennis were the known malaria vectors ... Link to item Cite

Visible light photochemical release of nitric oxide from S-nitrosoglutathione: potential photochemotherapeutic applications.

Journal Article Photochem Photobiol · April 1994 Some aspects of the physiological role of NO may be mediated by stable NO-carriers such as S-nitrosoglutathione and related S-nitrosothiols. In this report we show that irradiation of S-nitrosoglutathione at either absorption band (lambda max = 340 nm or 5 ... Full text Link to item Cite

New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service.

Journal Article Am J Med · March 1994 PURPOSE: This study was designed to develop improved criteria for the diagnosis of infective endocarditis and to compare these criteria with currently accepted criteria in a large series of cases. PATIENTS AND METHODS: A total of 405 consecutive cases of s ... Full text Link to item Cite

The use of a polymerase chain reaction as a diagnostic test for Rocky Mountain spotted fever.

Journal Article Am J Trop Med Hyg · January 1994 A polymerase chain reaction (PCR) for amplifying ribosomal DNA of Rickettsia rickettsii was performed on blood clots and urine samples from 10 patients with suspected Rocky Mountain spotted fever (RMSF) and five controls with nonrickettsial diseases. The r ... Link to item Cite

Impregnated bed nets for malaria control: biological success and social responsibility.

Journal Article Am J Trop Med Hyg · 1994 Malaria is a serious public health problem in numerous countries of the world. In Africa alone, it is estimated that more than a million children less than five years of age die each year from this disease. The problem has become more critical with the dev ... Full text Link to item Cite

A case-control study of nosocomial ampicillin-resistant enterococcal infection and colonization at a university hospital.

Journal Article Infect Control Hosp Epidemiol · November 1993 OBJECTIVE: To assess risk factors for colonization and nosocomial infection with ampicillin-resistant enterococci (ARE). DESIGN: Patients with ampicillin-resistant enterococci were compared retrospectively by logistic regression analysis with controls harb ... Full text Link to item Cite

Postoperative pubic osteomyelitis misdiagnosed as osteitis pubis: report of four cases and review.

Journal Article Clin Infect Dis · October 1993 Osteitis pubis is a painful inflammatory process resulting in bony destruction of the margins of the symphysis pubis. Despite six decades of speculation, the pathogenesis of, criteria for diagnosis of, natural history of, and optimal therapy for osteitis p ... Full text Link to item Cite

Permethrin-impregnated bed nets for malaria control in northern Guatemala: epidemiologic impact and community acceptance.

Journal Article Am J Trop Med Hyg · October 1993 Permethrin-impregnated bed nets were evaluated as a control measure for malaria in northern Guatemala. Twelve hundred forty participants were allocated to one of three experimental groups (impregnated bed nets [IBN], untreated bed nets [UBN], and controls) ... Full text Link to item Cite

Brazilian spotted fever in Espirito Santo, Brazil: description of a focus of infection in a new endemic region.

Journal Article Am J Trop Med Hyg · August 1993 Although Brazilian spotted fever is known to occur in several adjacent states, infection with spotted fever group (SFG) rickettsiae has not previously been documented in the Brazilian state of Espirito Santo. We report a cluster of two proven and four susp ... Full text Link to item Cite

Acute pubic osteomyelitis.

Journal Article Clin Infect Dis · June 1993 Full text Link to item Cite

Rocky Mountain spotted fever complicated by gangrene: report of six cases and review.

Journal Article Clin Infect Dis · May 1993 Although mortality due to fulminant Rocky Mountain spotted fever (RMSF) is well appreciated, the ability of the disease to cause survivors to become permanently disabled is not as widely known. We report six cases of RMSF complicated by gangrene. Although ... Full text Link to item Cite

RECURRENT VIBRIO-VULNIFICUS CELLULITIS AND BACTEREMIA

Journal Article INFECTIOUS DISEASES IN CLINICAL PRACTICE · 1993 Full text Link to item Cite

A spectrophotometric glutathione S-transferase assay displaying alpha-class selectivity utilizing 1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3- one hydrobromide.

Journal Article Biochem Cell Biol · 1993 The conjugation of 1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3- one hydrobromide (CDDP), a Mannich base of an alpha,beta-unsaturated ketone, to glutathione is catalyzed selectively by alpha-class glutathione S-transferase. The reaction of CDDP ... Full text Link to item Cite

Glutathione reductases from a variety of sources are inhibited by physiological levels of glutathione.

Journal Article Comp Biochem Physiol B · December 1992 1. Glutathione reductase from human platelets, bovine intestinal mucosa, yeast and E. coli were inhibited in vitro by physiological levels of reduced glutathione with IC50s of 6.61 mM, 2.92 mM, 2.40 mM and 12.11 mM, respectively. 2. A steady-state kinetic ... Full text Link to item Cite

HIV transmission in a dental practice.

Journal Article Ann Intern Med · November 1, 1992 Link to item Cite

HIV transmission in a dental practice.

Journal Article Ann Intern Med · November 1, 1992 Link to item Cite

Rocky Mountain "spotless" and "almost spotless" fever: a wolf in sheep's clothing.

Journal Article Clin Infect Dis · September 1992 In 10 (10.8%) of 93 laboratory-confirmed or probable cases of Rocky Mountain spotted fever seen at Duke University Medical Center from 1969 to 1991, illness without rash or fleeting or atypical skin eruptions were noted. Data from these 10 cases and 33 sim ... Full text Link to item Cite

Zidovudine and the natural history of AIDS.

Journal Article N Engl J Med · October 31, 1991 Full text Link to item Cite

ZIDOVUDINE AND THE NATURAL-HISTORY OF AIDS

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · October 31, 1991 Link to item Cite

Prevalence of antibodies to spotted fever group rickettsiae in dogs from southeastern Australia.

Journal Article Am J Trop Med Hyg · August 1991 Recent epidemiologic data suggests that Rickettsia australis, the cause of Queensland tick typhus, is present in southeastern Australia. In order to further confirm this observation, a canine serosurvey was undertaken to determine if naturally occurring an ... Full text Link to item Cite

Twice daily intramuscular imipenem/cilastatin in the treatment of skin and soft tissue infections.

Journal Article Chemotherapy · 1991 One hundred and two patients were enrolled in an open-label evaluation of intramuscular imipenem/cilastatin using doses of either 500 or 750 mg every 12 h in the treatment of mild to moderately severe skin and soft tissue infections. Seventy-four of 102 pa ... Full text Link to item Cite

Spotted fever group rickettsial infections in Australia.

Journal Article Rev Infect Dis · 1991 More than four decades ago, Rickettsia australis was discovered to be the etiologic agent of Queensland tick typhus (QTT), yet many unanswered questions persist about the ecology, epidemiology, and clinical features of this disease. We review 46 previously ... Full text Link to item Cite

Fatal Queensland tick typhus.

Journal Article J Infect Dis · September 1990 Full text Link to item Cite

Osteomyelitis: approaching the 1990s.

Journal Article Med J Aust · July 16, 1990 Link to item Cite

Permethrin-impregnated curtains and bed-nets prevent malaria in western Kenya.

Journal Article Am J Trop Med Hyg · July 1990 The effectiveness of permethrin-impregnated (0.5 g/m2) bed-nets and curtains as malaria control measures was evaluated in Uriri, Kenya in 1988. One hundred five families were randomly assigned to 1 of 3 study groups (control, bed-net, or curtain). All part ... Full text Link to item Cite

Randomized, double-blind trial of cefonicid and nafcillin in the treatment of skin and skin structure infections.

Journal Article Antimicrob Agents Chemother · April 1990 We compared treatment with one daily intravenous dose of cefonicid and multidose nafcillin in 65 patients with severe infections of the skin or skin structure. Clinical cure or improvement was achieved in 91% of the patients given cefonicid and in 87% of t ... Full text Link to item Cite

Rocky Mountain spotted fever. A clinical review based on 48 confirmed cases, 1943-1986.

Journal Article Medicine (Baltimore) · January 1990 We reviewed 48 cases of Rocky Mountain spotted fever seen between 1943 and 1986. The data provided a view of the diverse presentations and manifestations of this disease. Exposure to a rural environment or to dogs was the rule, and over two-thirds of patie ... Link to item Cite

HIV-associated myocarditis treated with zidovudine (AZT).

Journal Article Tex Heart Inst J · 1989 Congestive cardiomyopathy has been reported in patients infected with human immunodeficiency virus (HIV). In this report of diffuse lymphocytic myocarditis in a patient who tested positive for HIV antibody after receiving blood from an HIV-positive donor, ... Link to item Cite

Parasitologic and clinical efficacy of 25 and 50 mg/kg of chloroquine for treatment of Plasmodium falciparum malaria in Rwandan children.

Journal Article Am J Trop Med Hyg · March 1988 The standard chloroquine treatment for Plasmodium falciparum malaria is 25 mg (base)/kg (C25) given over 3 days. In Rwanda, 50 mg/kg (C50) administered over 6 days has been recommended by the Faculty of Medicine, Ministry of Health. The present study compa ... Full text Link to item Cite

Amodiaquine and sulfadoxine-pyrimethamine as treatment for chloroquine-resistant Plasmodium falciparum in Rwanda.

Journal Article Am J Trop Med Hyg · March 1988 The efficacy of amodiaquine and sulfadoxine-pyrimethamine combination as a second-line therapy for chloroquine-resistant Plasmodium falciparum infections was investigated in Rwanda in September 1986. Children less than or equal to 5 years old presenting wi ... Full text Link to item Cite

Response of children with Plasmodium falciparum to chloroquine and development of a national malaria treatment policy in Zaire.

Journal Article Trans R Soc Trop Med Hyg · 1988 In vivo sensitivity of Plasmodium falciparum to chloroquine was evaluated in 4 of 9 regions of Zaire in 1985 to develop a national strategy for treatment of malaria. Children less than 5 years of age were treated with either a single dose of chloroquine ba ... Full text Link to item Cite

Immunization is the adult thing to do.

Journal Article J Okla State Med Assoc · October 1987 Link to item Cite

Impact of education on cephalosporin prescribing patterns.

Journal Article J Okla State Med Assoc · September 1987 Link to item Cite

Interactions between precipitating and nonprecipitating antibodies in the formation of immune complexes.

Journal Article J Immunol · April 15, 1987 In the present study, we used monoclonal antidinitrophenol (DNP) antibodies to determine certain of the biophysical characteristics of precipitating and nonprecipitating antibodies. In addition, we studied the dynamics of immune complex (IC) formation when ... Link to item Cite

Clinical diagnosis of endophthalmitis.

Journal Article Int Ophthalmol Clin · 1987 Full text Link to item Cite

The biting and resting behavior of Anopheles albimanus in northern Haiti.

Journal Article J Am Mosq Control Assoc · June 1986 A one-year study of the biting and resting habits of the malaria vector Anopheles albimanus was carried out in four rural villages of northern Haiti. Man-biting rates and nightly biting cycles were determined by the use of all-night man-biting captures ins ... Link to item Cite

Comparison of an experimental updraft ultraviolet light trap with the CDC miniature light trap and biting collections in sampling for Anopheles albimanus in Haiti.

Journal Article J Am Mosq Control Assoc · June 1986 Three methods of capturing Anopheles albimanus mosquitoes were compared during a field study in four villages in northern Haiti. Updraft ultraviolet (UV) light traps proved to be more effective than biting collections, regardless of season or whether the t ... Link to item Cite

Rocky Mountain spotted fever.

Journal Article Arch Intern Med · December 1985 Link to item Cite

Mucormycosis after open fracture injury.

Journal Article South Med J · December 1985 An 18-year-old woman (a former intravenous drug abuser) sustained open tibial plateau and shaft fractures, followed by cellulitis and a wound infection caused by a Rhizopus species, which is a fungus of the class Mucorales. The patient responded to surgica ... Full text Link to item Cite

Pregnancy-associated group B streptococcal endocarditis: a report of two fatal cases.

Journal Article Obstet Gynecol · September 1985 Group B streptococci commonly colonize parturient women, yet pregnancy-associated endocarditis due to this organism is rare. Most reports of group B streptococcal endocarditis are from the preantibiotic era and occurred in women with rheumatic mitral valve ... Link to item Cite

Pregnancy-associated group B streptococcal endocarditis: A report of two fatal cases

Journal Article Obstetrics and Gynecology · January 1, 1985 Group B streptococci commonly colonize parturient women, yet pregnancy-associated endocarditis due to this organism is rare. Most reports of group B streptococcal endocarditis are from the preantibiotic era and occurred in women with rheumatic mitral valve ... Cite

Pregnancy-associated group B streptococcal endocarditis: A report of two fatal cases

Journal Article Obstetrics and Gynecology · 1985 Group B streptococci commonly colonize parturient women, yet pregnancy-associated endocarditis due to this organism is rare. Most reports of group B streptococcal endocarditis are from the preantibiotic era and occurred in women with rheumatic mitral valve ... Cite

In vivo and in vitro susceptibility to chloroquine of Plasmodium falciparum in Kinshasa and Mbuji-Mayi, Zaire.

Journal Article Bull World Health Organ · 1985 From April to June 1983, combined in vivo and in vitro studies were conducted to assess the response to chloroquine of Plasmodium falciparum in Kinshasa and Mbuji-Mayi, Zaire. A total of 109 patients were treated with chloroquine, either as a single dose o ... Link to item Cite

Immune deficiency presenting as disseminated sporotrichosis.

Journal Article J Okla State Med Assoc · April 1984 Link to item Cite

Endophthalmitis: current approaches.

Journal Article Ophthalmology · September 1982 Seventy patients referred with a diagnosis of endophthalmitis underwent anterior chamber and vitreous taps with intracameral antibiotic injections. Fifty-four eyes were culture positive, 34 (63%) after previous intraocular surgery, 12 (22%) had sustained p ... Full text Link to item Cite

Cytomegalovirus infection and chronic hemodialysis.

Journal Article Clin Nephrol · January 1979 Serologic and virologic studies of cytomegalovirus (CMV), a virus infection often disseminated in immunosuppressed patients, were initiated among hemodialysis patients, home dialysis partners, hemodialysis center personnel, and several groups of patients. ... Link to item Cite

Newer antibiotics.

Journal Article J Okla State Med Assoc · May 1978 Link to item Cite

Amebiasis: epidemiologic studies in the United States, 1971-1974.

Journal Article Ann Intern Med · January 1978 Seven investigations of suspected foci of amebiasis between October 1971 and June 1974 lead to three conclusions. (1) A number of laboratories have vastly overdiagnosed amebiasis and have reported leukocytes in stools as Entamoeba histolytica. Two laborato ... Full text Link to item Cite

A nonoccupational outbreak of inorganic mercury vapor poisoning.

Journal Article Arch Environ Health · 1978 An outbreak of inorganic mercury vapor poisoning involving 12 people occurred in a trailer park in Mississippi in 1973-74. For information concerning levels of mercury in hair and blood of humans with short-term exposures, these individuals were observed f ... Full text Link to item Cite

Endemic amebiasis in an extended family.

Journal Article Am J Trop Med Hyg · July 1977 Two cousins from a large Spanish-American family were simultaneously diagnosed as having amebic liver abscesses. Survey of 183 extended-family members revealed that 45.7% of 162 had a positive amebiasis indirect hemagglutination test and 12.6% of 111 had c ... Full text Link to item Cite

Inappropriate antidiuretic hormone secretion. Occurrence in a patient with Rocky Mountain spotted fever.

Journal Article Arch Intern Med · March 1977 A 51-year-old man with serologically confirmed Rocky Mountain spotted fever was believed to have inappropriate antidiuretic hormone (ADH) secretion. He was observed for four days in the hospital until the correct diagnosis was made. During this period, he ... Full text Link to item Cite

A comparison of serologic methods for diagnosis of Rocky Mountain spotted fever.

Journal Article Am J Epidemiol · January 1977 Sera referred to the North Carolina Division of Health Services for rickettsial serology in 1974 were tested by complement fixation (CF), microimmunofluorescence (micro-IF), microagglutination (MA) and hemagglutination (HA) for antibodies against Rickettsi ... Full text Link to item Cite

Rocky Mountain Spotted Fever: Diagnosis

Journal Article JAMA the Journal of the American Medical Association · September 6, 1976 Full text Cite

Rocky Mountain spotted fever in Mississippi: survey for spotted fever antibodies in dogs and for spotted fever group reckettsiae in dog ticks.

Journal Article Am J Epidemiol · February 1976 During epidemiologic studies of Rocky Mountain Spotted Fever in Mississippi in 1973, dogs were surveyed for antibodies tp spotted fever group antigens and for tick parasites infected with rickettsiae of the spotted fever group. Fifty-three (46%) of 116 ser ... Full text Link to item Cite

HYPONATREMIA IN ROCKY-MOUNTAIN SPOTTED-FEVER

Conference CLINICAL RESEARCH · January 1, 1976 Link to item Cite

Clinical and epidemiologic features of Rocky Mountain spotted fever in Mississippi, 1933-1973.

Journal Article South Med J · December 1975 During the period 1933-1973, 169 cases of Rocky Mountain spotted fever (RMSF) were either reported by physicians or detected in a retrospective survey of hospitals and practicing physicians in Mississippi. The epidemiologic characteristics of 119 cases and ... Full text Link to item Cite

Human-to-human transmission of Pseudomonas pseudomallei.

Journal Article Ann Intern Med · October 1975 Melioidosis, the clinical manifestation of infection with Pseudomonas pseudomallei, has occurred infrequently in American citizens; almost all reported cases have been in Vietnam veterans, usually associated with respiratory disease. A Vietnam veteran from ... Full text Link to item Cite

Rhipicephalus sanguineus: vector of a new spotted fever group rickettsia in the United States.

Journal Article Infect Immun · July 1975 A rickettsia related to but distinct from the spotted fever agent, Rickettsia rickettsii, has been detected in 167 (18.9%) of 884 Rhipicephalus sanguineus taken off dogs in central and northern Mississippi. The organisms could readily be isolated in male m ... Full text Link to item Cite

Tetanus in Mississippi, 1951-1973

Journal Article J Miss State MED Ass · January 1, 1974 Cite