Scholars@Duke
Chad E. Cook

Chad E. Cook

Professor in Orthopaedic Surgery
Orthopaedic Surgery, Physical Therapy
chad.cook@dm.duke.edu
DUMC 104002, 2200 W. Main St. Ste. B230, Durham, NC 27710
311 Trent Drive, Durham, NC 27710

Selected Publications

"I'm Not the Same as I Was Before": A Qualitative Evidence Synthesis Exploring the Experiences and Perceptions of Patients Living With Whiplash-Associated Disorders.

Journal Article J Orthop Sports Phys Ther · September 2025 OBJECTIVE: To summarize the perceptions and experiences of patients living with whiplash-associated disorders (WADs). DESIGN: Qualitative evidence synthesis. LITERATURE SEARCH: Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Lib ... Full text Link to item Cite

"I Cannot Recognize My Body": Experiences and Perceptions of Patients Living With Frozen Shoulder: A Qualitative Systematic Review With Meta-synthesis and Meta-summary.

Journal Article J Orthop Sports Phys Ther · September 2025 OBJECTIVE: To systematically synthesize and summarize findings from qualitative studies exploring the perceptions and experiences of individuals living with frozen shoulder. DESIGN: Systematic review of qualitative studies. LITERATURE SEARCH: The search st ... Full text Link to item Cite

The person-centered hypothesis framework: Advancing clinical reasoning in musculoskeletal pain management.

Journal Article Musculoskelet Sci Pract · August 23, 2025 INTRODUCTION: The Person-Centered Hypothesis (PCH) framework is a structured clinical reasoning model designed to enhance "in action" reasoning in person-centered care (PCC). The PCH integrates elements of the biopsychosocial model, pain phenotyping, and c ... Full text Link to item Cite

Comparative Effectiveness of Blood Flow Restriction Therapy versus Exercise Alone after Arthroscopic Rotator Cuff Repair: S-TRONGER Randomised Controlled Trial Protocol

Journal Article New Zealand Journal of Physiotherapy · July 31, 2025 The purpose of this trial is to evaluate the effect of postoperative exercises with blood flow restriction therapy (BFRT) for 12 weeks in patients undergoing arthroscopic rotator cuff repair, compared to postoperative exercises alone. Fifty-eight adults ag ... Full text Cite

Self-reported disability trajectories and their predictors among patients receiving care by physical therapists for musculoskeletal conditions: a retrospective analysis of registry data.

Journal Article BMJ Open · June 20, 2025 OBJECTIVES: To identify clustered trajectories of self-reported disability following the initiation of care by a physical therapist in outpatient orthopaedic settings and to determine baseline factors that distinguish between different trajectories. DESIGN ... Full text Link to item Cite

Understanding degenerative cervical myelopathy in musculoskeletal practice.

Journal Article J Man Manip Ther · June 2025 BACKGROUND: Degenerative cervical myelopathy (DCM) is a clinical syndrome characterized by a progressive compression of the spinal cord. DCM often looks like common symptoms of aging or bilateral carpal tunnel syndrome in its early stages, requiring carefu ... Full text Link to item Cite

Reporting and incorporation of social risks in low back pain and exercise studies: A scoping review.

Journal Article Musculoskelet Sci Pract · June 2025 BACKGROUND: Exercise is a common intervention for low back pain, but its effect sizes are small to modest. Social risk factors significantly influence health outcomes, yet their consideration in randomized controlled trials on exercise for low back pain is ... Full text Link to item Cite

Diagnostic accuracy of neurodynamic tests in upper-limb entrapment neuropathies: A systematic review and meta-analysis.

Journal Article Musculoskeletal science & practice · June 2025 BackgroundUpper-limb neurodynamic tests are commonly used to diagnose neuropathies in this area, including cervical radiculopathy and carpal tunnel syndrome, although their diagnostic accuracy remains uncertain across different conditions and crit ... Full text Cite

Reasons for patient no-shows and drop-offs after initial evaluation in physical therapy outpatient care: a qualitative study.

Journal Article Musculoskelet Sci Pract · June 2025 BACKGROUND: No-shows and drop-offs by patients after their initial physical therapy evaluation can significantly impact clinics and therapists. To our knowledge, no previous studies have examined the patient's perspective of why they terminated their recom ... Full text Link to item Cite

Myosteatosis and skeletal muscle atrophy, but not fibrosis, are correlated with increasing tear sizes of full-thickness rotator cuff tears.

Journal Article J Shoulder Elbow Surg · May 14, 2025 BACKGROUND: Rotator cuff tears (RCTs) are a common shoulder pathology associated with degenerative muscle changes, including fatty accumulation (myosteatosis), muscle atrophy, and fibrosis. The purpose of this study was to utilize immunohistochemistry to a ... Full text Link to item Cite

Knowledge and use, perceptions of benefits and limitations of artificial intelligence chatbots among Italian physiotherapy students: a cross-sectional national study.

Journal Article BMC Med Educ · April 18, 2025 BACKGROUND: Artificial Intelligence (AI) Chatbots (e.g., ChatGPT, Microsoft Bing, and Google Bard) can emulate human interaction and may support physiotherapy education. Despite growing interest, physiotherapy students' perspectives remain unexplored. This ... Full text Link to item Cite

Is the YES/NO classification accurate in screening scapular dyskinesis in asymptomatic individuals? - A novel validation study utilizing surface electromyography as a surrogate measure in identifying movement asymmetries.

Journal Article J Man Manip Ther · April 2025 BACKGROUND: Scapular dyskinesis is a known risk factor for shoulder pain, making it important to screen for prevention. Physical therapists screen scapular dyskinesis by visually comparing asymmetries in scapular movement during overhead reach using the Sc ... Full text Link to item Cite

Patient perspectives of process variables in musculoskeletal care pathways.

Journal Article Musculoskelet Sci Pract · April 2025 BACKGROUND: The prevalence of disability caused by musculoskeletal conditions continues to increase. Little research has considered the effect of process variables of a musculoskeletal care pathway on patient outcomes. A process variable is as any modifiab ... Full text Link to item Cite

Myofascial Pain Syndromes: Controversies and Suggestions for Improving Diagnosis and Treatment.

Journal Article J Orthop Sports Phys Ther · April 2025 SYNOPSIS: Myofascial pain syndromes (MPSs) affect a significant portion of the population. However, they remain controversial because their etiology, diagnostics, and effect mechanisms rely on theoretical frameworks with limited scientific rigor. This View ... Full text Link to item Cite

Context is complex: Challenges and opportunities addressing contextual factors in manual therapy mechanisms research

Journal Article International Journal of Osteopathic Medicine · March 1, 2025 Mechanistic studies on manual therapy (MT) have potential to allow better understanding of ‘why’ and ‘how’ MT interventions provide an effect. Contextual factors (CF) include the multitude of intrinsic and extrinsic inputs outside of the specific intervent ... Full text Cite

Categorizing Treatment Mechanisms for Complementary and Integrative Musculoskeletal Interventions.

Journal Article Int J Osteopath Med · March 2025 Treatment mechanisms (TM) reflect the steps or processes through which a treatment unfolds. However, TM research faces challenges due to inconsistent terminology and varying measurement approaches for each mechanism, which creates confusion and controversy ... Full text Link to item Cite

Rehabilitation Management of Neck Pain-Development of a Diagnostic Framework Based on the Pain and Disability Drivers Management Model.

Journal Article J Eval Clin Pract · February 2025 RATIONALE: Neck pain is a major cause of disability worldwide, and current rehabilitation strategies show limited effectiveness. Subgrouping patients by their primary pain and disability drivers can help tailor treatments. At this end, the Pain and Disabil ... Full text Link to item Cite

The Effectiveness of Spinal Manipulative Therapy in Treating Spinal Pain Does Not Depend on the Application Procedures: A Systematic Review and Network Meta-analysis.

Journal Article The Journal of orthopaedic and sports physical therapy · February 2025 OBJECTIVE: To assess whether spinal manipulative therapy (SMT) application procedures (ie, target, thrust, and region) impacted changes in pain and disability for adults with spine pain. DESIGN: Systematic review with network meta-analysis. < ... Full text Cite

Amniotic Tissue Injections Are an Effective Alternative to Corticosteroid Injections for Pain Relief and Function in Patients With Severe Knee Osteoarthritis: A Double-Blind, Randomized, Prospective Study.

Journal Article J Am Acad Orthop Surg Glob Res Rev · January 1, 2025 INTRODUCTION: The use of corticosteroid injections for short-term pain relief for knee osteoarthritis can have deleterious adverse effects. Amniotic tissue has shown promise in vitro; therefore, this study compared a morcellized injectable amniotic tissue ... Full text Link to item Cite

The mechanisms of manual therapy: A living review of systematic, narrative, and scoping reviews.

Journal Article PLoS One · 2025 INTRODUCTION: Treatment mechanisms are the underlying process or pathway through which a treatment influences the body. This includes molecular, cellular and physiological processes or pathways contributing to treatment effect. Manual therapy (MT) evokes c ... Full text Link to item Cite

Risk Factors Associated with New Onset of Shoulder Pain and Injury Among the Athletic Population: A Systematic Review of the Literature

Journal Article International Journal of Sports Physical Therapy · January 1, 2025 Introduction There is a high incidence of shoulder injuries among overhead athletes. Identifying and understanding risk factors for these injuries, particularly those that can be modified, is a necessary step towards being able to effectively develop and i ... Full text Cite

Accuracy of ChatGPT-3.5, ChatGPT-4o, Copilot, Gemini, Claude, and Perplexity in advising on lumbosacral radicular pain against clinical practice guidelines: cross-sectional study.

Journal Article Front Digit Health · 2025 INTRODUCTION: Artificial Intelligence (AI) chatbots, which generate human-like responses based on extensive data, are becoming important tools in healthcare by providing information on health conditions, treatments, and preventive measures, acting as virtu ... Full text Link to item Cite

Shoulder pain: to image or not to image?

Journal Article Front Rehabil Sci · 2025 Full text Link to item Cite

A Model to guide force-based manipulation research and practice.

Journal Article PLoS One · 2025 INTRODUCTION: Manual therapies are forms of force-based manipulations (FBM) and involve the application of mechanical force to the outside of the body with therapeutic intent. The United States National Institutes of Health (NIH) U24 FBM Taxonomy and Termi ... Full text Link to item Cite

Knowledge, use and perceptions of artificial intelligence Chatbots among Italian physiotherapists: an online cross-sectional survey.

Journal Article Front Digit Health · 2025 INTRODUCTION: Artificial Intelligence (AI) Chatbots are increasingly being integrated into healthcare, but little is known about their role in physiotherapy. This study investigated the knowledge and use, perceived benefits, limits, and barriers of AI Chat ... Full text Link to item Cite

Autonomic nervous system and endocrine system response to upper or lower cervical spine mobilization in males with persistent post-concussion symptoms: a proof-of-concept trial.

Journal Article J Man Manip Ther · December 2024 INTRODUCTION: The peripheral stress response, consisting of the autonomic nervous system (ANS) and hypothalamic pituitary adrenal-axis (HPA-axis), functions to maintain homeostasis in response to stressors. Cervical spine manual therapy has been shown to d ... Full text Link to item Cite

Prognostic factors of pain, disability, and poor outcomes in persons with neck pain - an umbrella review.

Journal Article Clinical rehabilitation · December 2024 ObjectiveThe aim of this study was to identify prognostic factors pertaining to neck pain from systematic reviews.Data sourcesA search on PubMed, Scopus, and CINAHL was performed on June 27, 2024. Additional grey literature searches were ... Full text Cite

A consensus-based agreement on a definition of a process variable: findings from a New Zealand nominal group technique study.

Journal Article BMC Health Serv Res · November 16, 2024 BACKGROUND: Musculoskeletal pain and disability are leading causes of reduced health and significant economic costs worldwide. Individualised, and evidence-based treatment approaches for specific musculoskeletal conditions aimed at improving patient outcom ... Full text Link to item Cite

The implementation of a pain navigator program in the department of Veterans Affairs' (VA) health care systems: a cluster randomized pragmatic clinical trial.

Journal Article Pain Med · November 1, 2024 OBJECTIVE: This manuscript describes the uptake of the AIM-Back Pain Navigator Pathway (PNP) designed to encourage use of non-pharmacologic care options within the Veterans Health Administration (VHA). DESIGN: This manuscript describes the implementation o ... Full text Link to item Cite

"Dear Newly Graduated Physical Therapist": A Direct Message Containing Advice We Wish We Had Received.

Journal Article J Orthop Sports Phys Ther · October 2024 SYNOPSIS: This Viewpoint provides practical guidance for early-career musculoskeletal clinicians who are navigating the complexities of clinical practice. Key themes are embracing uncertainty, seeing and treating the whole person, avoiding judgemental mind ... Full text Link to item Cite

Identifying which adverse events associated with dry needling should be included for informed consent: A modified e-Delphi study.

Journal Article Physiother Theory Pract · August 2024 OBJECTIVE: Dry needling (DN) uses a monofilament needle to reduce pain and is performed by various healthcare professions. Due to the invasive needle puncture, adverse events (AEs) have been associated with DN. It is unclear, which AEs should be included i ... Full text Link to item Cite

How long does tendinopathy last if left untreated? Natural history of the main tendinopathies affecting the upper and lower limb: A systematic review and meta-analysis of randomized controlled trials.

Journal Article Musculoskelet Sci Pract · August 2024 BACKGROUND: Natural history of disease refers to the progression of a disease process in an individual over time, in the absence of treatment. Understanding natural history of tendinopathies is key for clinicians to make accurate prognostic predictions and ... Full text Link to item Cite

Comparative accuracy of ChatGPT-4, Microsoft Copilot and Google Gemini in the Italian entrance test for healthcare sciences degrees: a cross-sectional study.

Journal Article BMC Med Educ · June 26, 2024 BACKGROUND: Artificial intelligence (AI) chatbots are emerging educational tools for students in healthcare science. However, assessing their accuracy is essential prior to adoption in educational settings. This study aimed to assess the accuracy of predic ... Full text Link to item Cite

Unaccounted for Pitch Volume Among Adolescent Baseball Pitchers During a Travel Baseball Season.

Journal Article Clin J Sport Med · June 19, 2024 OBJECTIVE: The primary aim was to compare differences in live game pitch counts (LGPCs) with all pitch counts (APCs) over the course of a youth baseball season. DESIGN: Prospective longitudinal study. SETTING: Midwest youth travel baseball. PARTICIPANTS: T ... Full text Link to item Cite

Orthopaedic Manual Physical Therapy: A Modern Definition and Description.

Journal Article Phys Ther · June 4, 2024 Currently, orthopaedic manual physical therapy (OMPT) lacks a description of practice that reflects contemporary thinking and embraces advances across the scientific, clinical, and educational arms of the profession. The absence of a clear definition of OM ... Full text Link to item Cite

Association between radiographic soft-tissue thickness and increased length of stay, operative time, and infection rate after reverse shoulder arthroplasty.

Journal Article J Shoulder Elbow Surg · June 2024 BACKGROUND: Reverse shoulder arthroplasty (RSA) is a widely performed surgical procedure to address various shoulder pathologies. Several studies have suggested that radiographic soft-tissue thickness may play a role in predicting complications after ortho ... Full text Link to item Cite

Contextual Factors-Enriched Standard Care on mechanical neck pain (ContextualizAR trial): Protocol for a randomised controlled trial.

Journal Article Musculoskeletal Care · June 2024 BACKGROUND: Understanding the influence of contextual factors (CFs) on interventions for mechanical neck pain (MNP) is essential for evidence-based practice in physical therapy. However, the specific effects and synergies of combining different CFs remain ... Full text Link to item Cite

A modern way to teach and practice manual therapy.

Journal Article Chiropr Man Therap · May 21, 2024 BACKGROUND: Musculoskeletal conditions are the leading contributor to global disability and health burden. Manual therapy (MT) interventions are commonly recommended in clinical guidelines and used in the management of musculoskeletal conditions. Tradition ... Full text Link to item Cite

Waste not, want not: call to action for spinal manipulative therapy researchers.

Journal Article Chiropr Man Therap · May 14, 2024 BACKGROUND: Research waste is defined as research outcomes with no or minimal societal benefits. It is a widespread problem in the healthcare field. Four primary sources of research waste have been defined: (1) irrelevant or low priority research questions ... Full text Link to item Cite

The value of Clinical signs in the diagnosis of Degenerative Cervical Myelopathy - A Systematic review and Meta-analysis.

Journal Article Global Spine J · May 2024 STUDY DESIGN: Delayed diagnosis of degenerative cervical myelopathy (DCM) is likely due to a combination of its subtle symptoms, incomplete neurological assessments by clinicians and a lack of public and professional awareness. Diagnostic criteria for DCM ... Full text Link to item Cite

The Frequency of Symptoms in Patients With a Diagnosis of Degenerative Cervical Myelopathy: Results of a Scoping Review.

Journal Article Global Spine J · May 2024 STUDY DESIGN: Delayed diagnosis of degenerative cervical myelopathy (DCM) is associated with reduced quality of life and greater disability. Developing diagnostic criteria for DCM has been identified as a top research priority. OBJECTIVES: This scoping rev ... Full text Link to item Cite

Deciphering classification systems for neck pain—Understanding the content of classification systems to enhance physiotherapy management of neck pain

Journal Article Musculoskeletal Care · March 1, 2024 Background: Neck pain is a prevalent and disabling condition. Conservative management of this condition has shown only moderate effects. A solution to improve treatment effectiveness is to sub-group patients into a classification system (CS) that allows fo ... Full text Cite

Nociceptive, neuropathic, or nociplastic low back pain? The low back pain phenotyping (BACPAP) consortium's international and multidisciplinary consensus recommendations.

Journal Article Lancet Rheumatol · March 2024 The potential to classify low back pain as being characterised by dominant nociceptive, neuropathic, or nociplastic mechanisms is a clinically relevant issue. Preliminary evidence suggests that these low back pain phenotypes might respond differently to tr ... Full text Link to item Cite

Performance of ChatGPT Compared to Clinical Practice Guidelines in Making Informed Decisions for Lumbosacral Radicular Pain: A Cross-sectional Study.

Journal Article J Orthop Sports Phys Ther · March 2024 OBJECTIVE: To compare the accuracy of an artificial intelligence chatbot to clinical practice guidelines (CPGs) recommendations for providing answers to complex clinical questions on lumbosacral radicular pain. DESIGN: Cross-sectional study. METHODS: We ex ... Full text Link to item Cite

Identifying priority gaps in contextual factors research and force-based manipulation. An international and interdisciplinary Delphi study.

Journal Article J Man Manip Ther · February 2024 OBJECTIVE: To establish priority gaps related to contextual factors (CFs) research and force-based manipulation (FBM). METHODS: A three-round Delphi following recommended guidelines for conducting and reporting Delphi studies (CREDES) involving internation ... Full text Link to item Cite

An international consensus on gaps in mechanisms of forced-based manipulation research: findings from a nominal group technique.

Journal Article J Man Manip Ther · February 2024 Force-Based Manipulation (FBM) including light touch, pressure, massage, mobilization, thrust manipulation, and needling techniques are utilized across several disciplines to provide clinical analgesia. These commonly used techniques demonstrate the abilit ... Full text Link to item Cite

Specific and shared mechanisms associated with treatment for chronic neck pain: study protocol for the SS-MECH trial.

Journal Article J Man Manip Ther · February 2024 BACKGROUND: Treatment mechanisms involve the steps or processes through which an intervention unfolds and produces change in an outcome variable. Treatment mechanisms can be specific to the intervention provided (i.e. pain modulation) or shared with other ... Full text Link to item Cite

Wearable Devices to Improve Physical Activity and Reduce Sedentary Behaviour: An Umbrella Review.

Journal Article Sports Med Open · January 14, 2024 BACKGROUND: Several systematic reviews (SRs), with and without meta-analyses, have investigated the use of wearable devices to improve physical activity, and there is a need for frequent and updated syntheses on the topic. OBJECTIVE: We aimed to evaluate w ... Full text Link to item Cite

CLINICAL REASONING USINGSYSTEM 1 AND SYSTEM 2 MODELING

Chapter · January 1, 2024 I back away from conscious thought and turn the problem over to my unconscious mind. It will scan a broader array of patterns and find some new close fits from other information stored in my brain. -Arthur Fry, co-creator of the Post-it Note. ... Full text Cite

Early post-operative walking bouts are associated with improved gait speed and symmetry at 90 days.

Journal Article Gait Posture · January 2024 INTRODUCTION: There is a paucity of literature on optimal patterns of daily walking following joint arthroplasty, which are now evaluated with consumer technologies like smartphones, and can enhance our understanding of post-operative mobility. When smartp ... Full text Link to item Cite

Minimal Clinically Important Differences in Hand Pain Intensity (Numerical Pain Rate Scale) and Related-Function (Boston Carpal Tunnel Questionnaire) in Women With Carpal Tunnel Syndrome.

Journal Article Arch Phys Med Rehabil · January 2024 OBJECTIVE: To calculate the minimal clinically important differences (MCIDs) for hand pain intensity and the Boston Carpal Tunnel Questionnaire (BCTQ) in a sample of women with carpal tunnel syndrome (CTS). DESIGN: Secondary analysis of a randomized contro ... Full text Link to item Cite

Manual therapy and exercise effects on inflammatory cytokines: a narrative overview.

Journal Article Front Rehabil Sci · 2024 BACKGROUND: Matching disease and treatment mechanisms is a goal of the Precision Medicine Initiative. Pro- and anti-inflammatory cytokines (e.g., Tumor Necrosis Factor-alpha, Transforming Growth Factor-beta, and Interleukin-2, 10, and 12) have gained a sig ... Full text Link to item Cite

Treatment fidelity in clinical trials.

Journal Article Arch Physiother · 2024 In the context of clinical trials, treatment fidelity (TF) has traditionally referred to the extent to which an intervention or treatment is implemented by the clinicians as intended by the researchers who designed the trial. Updated definitions of TF have ... Full text Link to item Cite

Grieve's Modern Musculoskeletal Physiotherapy, Fifth Edition

Book · January 1, 2024 Originally edited by Gregory Grieve, a founder of modern manual therapy, the fifth edition of Grieve's Modern Musculoskeletal Physiotherapy continues to offer contemporary evidence, models of diagnosis and practice that make this one of the most highly res ... Cite

1.1 Introduction to the Text

Chapter · January 1, 2024 Full text Cite

3.4.10 Consensus Research

Chapter · January 1, 2024 Full text Cite

Autonomic nervous system and endocrine system response to upper and lower cervical spine mobilization in healthy male adults: a randomized crossover trial.

Journal Article J Man Manip Ther · December 2023 BACKGROUND: Cervical spine mobilizations may differentially modulate both components of the stress response, consisting of the autonomic nervous system and hypothalamic pituitary adrenal-axis, depending on whether the target location is the upper or lower ... Full text Link to item Cite

What factors do physical therapists consider when determining patient prognosis: A mixed methods study.

Journal Article Musculoskeletal Care · December 2023 INTRODUCTION: A prognosis provides valuable information to expected progress and anticipated outcome over the course of care. Although it is known that physical therapists can accurately prognose, it is unknown what factors are utilised in clinical practic ... Full text Link to item Cite

Effect of a Patient Engagement, Education, and Restructuring of Cognitions (PEERC) approach on conservative care in rotator cuff related shoulder pain treatment: a randomized control trial.

Journal Article BMC Musculoskelet Disord · December 1, 2023 BACKGROUND: Despite similar outcomes for surgery and physical therapy (PT), the number of surgeries to treat rotator cuff related shoulder pain (RCRSP) is increasing. Interventions designed to enhance treatment expectations for PT have been shown to improv ... Full text Link to item Cite

Pros and Cons of Using Artificial Intelligence Chatbots for Musculoskeletal Rehabilitation Management.

Journal Article J Orthop Sports Phys Ther · December 2023 SYNOPSIS: Artificial intelligence (AI), specifically large language models (LLMs), which focus on the interaction between computers and human language, can influence musculoskeletal rehabilitation management. AI chatbots (eg, ChatGPT, Microsoft Bing, and G ... Full text Link to item Cite

Creation and Validation of the Select Medical Patient Reported Experience Measure for Physical and Occupational Therapy Outpatient Clinics.

Journal Article Arch Phys Med Rehabil · November 2023 OBJECTIVE: This study describes the creation and examination of the internal consistency, content validity, construct/structural validity, and criterion/concurrent validity of the Select Medical Patient Reported Experience Measure (SM-PREM). DESIGN: Observ ... Full text Link to item Cite

Sociodemographic Trends in Telemedicine Visit Completion in Spine Patients During the COVID-19 Pandemic.

Journal Article Spine (Phila Pa 1976) · November 1, 2023 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: This study identifies potential disparities in telemedicine utilization in the wake of the COVID-19 pandemic and its aftermath in patients receiving spine surgery. SUMMARY OF BACKGROUND DATA: COVID-19 le ... Full text Open Access Link to item Cite

Responder Analyses: A Methodological Mess.

Journal Article J Orthop Sports Phys Ther · November 2023 SYNOPSIS: Responder analyses are methods for analyzing randomized controlled trials, which purport to identify individuals or subgroups of study participants who experienced a "clinically meaningful" improvement from a treatment. Unfortunately, responder a ... Full text Link to item Cite

Toward Shared Decision-Making in Degenerative Cervical Myelopathy: Protocol for a Mixed Methods Study.

Journal Article JMIR Res Protoc · October 9, 2023 BACKGROUND: Health care decisions are a critical determinant in the evolution of chronic illness. In shared decision-making (SDM), patients and clinicians work collaboratively to reach evidence-based health decisions that align with individual circumstance ... Full text Link to item Cite

The Association Between Sociodemographic Factors, Social Determinants of Health, and Spine Surgical Patient Portal Utilization.

Journal Article Clin Spine Surg · October 1, 2023 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To examine patient portal use among the surgical spine patient population across different sociodemographic groups and assess the impact of patient portal use on clinical outcomes. SUMMARY OF BACKGROUND ... Full text Open Access Link to item Cite

Optimising management of low back pain through the pain and disability drivers management model: Findings from a pilot cluster nonrandomised controlled trial.

Journal Article Musculoskeletal Care · September 2023 INTRODUCTION: Low back pain (LBP) remains the leading cause of disability. The Low Back Pain and Disability Drivers Management (PDDM) model aims to identify the domains driving pain and disability to guide clinical decisions. The objectives of this study w ... Full text Link to item Cite

Protocol for the development of a 'trustworthy' living systematic review and meta analyses of manual therapy interventions to treat neuromusculoskeletal impairments.

Journal Article J Man Manip Ther · August 2023 BACKGROUND: Preprocessed research resources are believed to be highly 'trustworthy' when translating research to clinical practice. However, the overall 'trustworthiness' is unknown if this evidence contains randomized clinical trials (RCTs) where prospect ... Full text Link to item Cite

The cervical spine in tension type headache.

Journal Article Musculoskelet Sci Pract · August 2023 INTRODUCTION: The concept that headaches may originate in the cervical spine has been discussed over decades and is still a matter of debate. The cervical spine has been traditionally linked to cervicogenic headache; however, current evidence supports the ... Full text Link to item Cite

Creation of a risk of harms informed consent form for dry needling: A nominal group technique.

Journal Article Musculoskelet Sci Pract · August 2023 BACKGROUND: When consenting patients to dry needling treatment, it is necessary to inform patients of potential risks of harms. OBJECTIVES: The aim of this study was to identify elements and framework for an Informed Consent (IC) risk of harm statement to ... Full text Link to item Cite

Cracking the code: unveiling the specific and shared mechanisms behind musculoskeletal interventions.

Journal Article Arch Physiother · July 6, 2023 BACKGROUND: Mechanisms reflect the steps or processes through which an intervention unfolds and produces change in a specified outcome variable. Mechanisms are responsible for determining "how treatments work" which has emerged as a critical question for b ... Full text Link to item Cite

Pain associated psychological distress is more strongly associated with shoulder pain and function than tear severity in patients undergoing rotator cuff repair.

Journal Article JSES Int · July 2023 BACKGROUND: Psychological distress has been associated with declining shoulder function in patients with rotator cuff tears (RCTs). Thus, we aimed to 1) evaluate the absence or presence of differences in shoulder pain, function, or pain-associated psycholo ... Full text Link to item Cite

Using Randomized Controlled Trials in the Sports Medicine and Performance Environment: Is It Time to Reconsider and Think Outside the Methodological Box?

Journal Article J Orthop Sports Phys Ther · June 2023 SYNOPSIS: Randomized controlled trials (RCTs) are ubiquitous in medicine and have facilitated great strides in clinical care. However, when applied in sport, RCTs have limitations that hinder implementing effective interventions in the real-world clinical ... Full text Link to item Cite

Modernizing patient-centered manual therapy: Findings from a Delphi study on orthopaedic manual therapy application.

Journal Article Musculoskelet Sci Pract · June 2023 BACKGROUND: Recent literature challenges the process by which orthopaedic manual therapy (OMT) has traditionally been applied. Progressive understanding of the complexities surrounding OMT analgesia and the decreased reliance on technique specific characte ... Full text Link to item Cite

Six Externally Validated Prognostic Models Have Potential Clinical Value to Predict Patient Health Outcomes in the Rehabilitation of Musculoskeletal Conditions: A Systematic Review.

Journal Article Phys Ther · May 4, 2023 OBJECTIVE: The purpose of this systematic review was to identify and appraise externally validated prognostic models to predict a patient's health outcomes relevant to physical rehabilitation of musculoskeletal (MSK) conditions. METHODS: We systematically ... Full text Link to item Cite

Social Risk Factors Are Associated With Disability Prevalence - Results From 17 States in the 2017 Behavioral Risk Factor Surveillance System.

Journal Article Am J Health Promot · May 2023 PURPOSE: Determine the association between incremental increases in the number of social risk factors and the prevalence of any disability and disability type. DESIGN: The cross-sectional analysis was conducted using 2017 Behavioral Risk Factor Surveillanc ... Full text Link to item Cite

The effectiveness of spinal manipulative therapy procedures for spine pain: protocol for a systematic review and network meta-analysis.

Journal Article Chiropractic & manual therapies · May 2023 BackgroundSpinal manipulative therapy (SMT) is a guideline-recommended treatment option for spinal pain. The recommendation is based on multiple systematic reviews. However, these reviews fail to consider that clinical effects may depend on SMT "a ... Full text Cite

"Trustworthiness," confidence in estimated effects, and confidently translating research into clinical practice.

Journal Article Arch Physiother · April 6, 2023 Trustworthy, preprocessed sources of evidence, such as systematic reviews and clinical practice guidelines, are crucial for practicing clinicians. Confidence in estimated effects is related to how different the outcome data were between the two groups. Fac ... Full text Link to item Cite

Does Surgery for Cruciate Ligament and Meniscus Injury Increase the Risk of Comorbidities at 2 Years in the Military System?

Journal Article J Knee Surg · April 2023 This study aims to determine whether surgery for cruciate ligament (anterior or posterior) or meniscus injury increased risks of subsequent comorbidities in beneficiaries of the Military Health System. The study was a retrospective case-control design in w ... Full text Link to item Cite

High-Impact Chronic Pain Transition in Lumbar Surgery Recipients.

Journal Article Pain Med · March 1, 2023 OBJECTIVE: High-impact chronic pain (HICP) is a term that characterizes the presence of a severe and troubling pain-related condition. To date, the prevalence of HICP in lumbar spine surgery recipients and their HICP transitions from before to after surger ... Full text Open Access Link to item Cite

Understanding barriers to adherence to home exercise programs in patients with musculoskeletal neck pain.

Journal Article Musculoskelet Sci Pract · February 2023 BACKGROUND: Home exercise program (HEP) prescription is commonplace in physical therapy (PT). Adherence to HEPs is generally poor, with non-adherence as high as 70%. Poor adherence may negatively impact outcomes. OBJECTIVES: To (i) qualitatively assess pat ... Full text Link to item Cite

Priorities in updating training paradigms in orthopedic manual therapy: an international Delphi study.

Journal Article J Educ Eval Health Prof · 2023 PURPOSE: Orthopedic manual therapy (OMT) education demonstrates significant variability between philosophies and while literature has offered a more comprehensive understanding of the contextual, patient specific, and technique factors which interact to in ... Full text Link to item Cite

An international consensus definition for contextual factors: findings from a nominal group technique.

Journal Article Front Psychol · 2023 OBJECTIVE: Emerging literature suggests contextual factors are important components of therapeutic encounters and may substantially influence clinical outcomes of a treatment intervention. At present, a single consensus definition of contextual factors, wh ... Full text Link to item Cite

Reliability of the scapular dyskinesis test yes-no classification in asymptomatic individuals between students and expert physical therapists.

Journal Article Clin Shoulder Elb · December 2022 BACKGROUND: Scapular dyskinesis is considered a risk factor for the shoulder pain that may warrant screening for prevention. Clinicians of all experience screen scapular dyskinesis using the scapular dyskinesis test yes-no classification (Y-N), yet its rel ... Full text Link to item Cite

Author Response to Shear et al.

Journal Article Phys Ther · October 6, 2022 Full text Link to item Cite

Identifying Factors That Influence Physical Activity Promotion in Outpatient Physical Therapist Practice Using the Theoretical Domains Framework.

Journal Article J Geriatr Phys Ther · October 2022 BACKGROUND AND PURPOSE: Physical activity (PA) promotion is not routine practice for physical therapists. Understanding the PA promotion beliefs of physical therapists may offer targets for behavior change interventions to improve PA promotion. The purpose ... Full text Link to item Cite

Classification of older adults who underwent lumbar-related surgery using pre-operative biopsychosocial predictors and relationships with surgical recovery: An observational study conducted in the United States.

Journal Article Health Soc Care Community · September 2022 Lumbar surgery is a commonly prescribed intervention for low back pain but poses higher risks and worse outcomes for older adults. Identifying clinical phenotypes based on biopsychosocial factors may help identify older adults who are at greatest risk for ... Full text Link to item Cite

The Collective Influence of Social Determinants of Health on Individuals Who Underwent Lumbar Spine Revision Surgeries: A Retrospective Cohort Study.

Journal Article World Neurosurg · September 2022 OBJECTIVE: To analyze the collective effect of social determinants of health (SDH) on lumbar spine revision surgery outcomes using a retrospective cohort study design. METHODS: Data from the Quality Outcomes Database were used, including 7889 adults who re ... Full text Link to item Cite

Differences in Outcomes between Patellar Dislocations Managed in Emergent versus Non-Emergent Care Settings.

Journal Article J Knee Surg · August 2022 Patellar dislocations occur at a much higher rate in military than civilian populations. Past population-level studies have shown that surgical management is as good as or superior to conservative care and may reduce future reoccurrences. Although in acute ... Full text Link to item Cite

Does Surgery for Concomitant Cruciate and Meniscus Injuries Increase or Decrease Subsequent Comorbidities at 2 Years?

Journal Article J Knee Surg · August 2022 Concomitant cruciate and meniscus injuries of the knee are generally associated with acute trauma and commonly treated with surgical intervention. Comorbidities (simultaneous presence of two or more medical conditions) may be acquired from changes in activ ... Full text Link to item Cite

Histologic Differences in Human Rotator Cuff Muscle Based on Tear Characteristics.

Journal Article J Bone Joint Surg Am · July 6, 2022 BACKGROUND: Fatty accumulation in the rotator cuff is associated with shoulder dysfunction and a risk of failure of rotator cuff repair. The aims of this study were to (1) describe cellular findings in rotator cuff muscles in patients presenting with varyi ... Full text Link to item Cite

High-impact chronic pain transition in surgical recipients with cervical spondylotic myelopathy.

Journal Article J Neurosurg Spine · July 1, 2022 OBJECTIVE: High-impact chronic pain (HICP) is a recently proposed metric that indicates the presence of a severe and troubling pain-related condition. Surgery for cervical spondylotic myelopathy (CSM) is designed to halt disease transition independent of c ... Full text Open Access Link to item Cite

Social risk factors predicting outcomes of cervical myelopathy surgery.

Journal Article J Neurosurg Spine · July 1, 2022 OBJECTIVE: Combinations of certain social risk factors of race, sex, education, socioeconomic status (SES), insurance, education, employment, and one's housing situation have been associated with poorer pain and disability outcomes after lumbar spine surge ... Full text Open Access Link to item Cite

Precise Analgesic Instructions Improve Narcotic Usage: A Randomized Trial.

Journal Article Aesthet Surg J · May 18, 2022 BACKGROUND: Given the ongoing battle with opioid abuse and overuse in the United States, new strategies are consistently being implemented to reduce opioid utilization and overprescribing. OBJECTIVES: The purpose of this study was to determine if a more re ... Full text Link to item Cite

Mastering Prognostic Tools: An Opportunity to Enhance Personalized Care and to Optimize Clinical Outcomes in Physical Therapy.

Journal Article Phys Ther · May 5, 2022 UNLABELLED: In health care, clinical decision making is typically based on diagnostic findings. Rehabilitation clinicians commonly rely on pathoanatomical diagnoses to guide treatment and define prognosis. Targeting prognostic factors is a promising way fo ... Full text Link to item Cite

Physical Activity Promotion: Moving From Talking the Talk to Walking the Walk.

Journal Article J Orthop Sports Phys Ther · May 2022 Despite its demonstrated efficacy, physical activity (PA) promotion is not routinely practiced by clinicians. We provide recommendations to improve PA promotion in routine clinical practice by (1) improving clinicians' capacity through enhancing knowledge, ... Full text Link to item Cite

Heterogeneity of pain-related psychological distress in patients seeking care for shoulder pathology.

Journal Article J Shoulder Elbow Surg · April 2022 BACKGROUND: Psychological distress is associated with disability and quality of life for patients with shoulder pain. However, uncertainty around heterogeneity of psychological distress has limited the adoption of shoulder care models that address psycholo ... Full text Link to item Cite

Do Short-Term Effects Predict Long-Term Improvements in Women Who Receive Manual Therapy or Surgery for Carpal Tunnel Syndrome? A Bayesian Network Analysis of a Randomized Clinical Trial.

Journal Article Phys Ther · April 1, 2022 OBJECTIVE: The purpose of this study was to develop a data-driven Bayesian network approach to understand the potential multivariate pathways of the effect of manual physical therapy in women with carpal tunnel syndrome (CTS). METHODS: Data from a randomiz ... Full text Link to item Cite

Physical Therapists' Knowledge, Skills, Beliefs, and Organizations Impact Physical Activity Promotion: A Systematic Review and Meta-Analysis.

Journal Article Phys Ther · March 1, 2022 OBJECTIVE: The purpose of this study was to characterize factors that influence physical therapists' physical activity (PA) promotion practices and map these factors to the Theoretical Domains Framework (TDF) to inform future implementation efforts. METHOD ... Full text Link to item Cite

Association of Burden and Prevalence of Arthritis With Disparities in Social Risk Factors, Findings From 17 US States.

Journal Article Prev Chronic Dis · February 17, 2022 INTRODUCTION: Social risks previously have been associated with arthritis prevalence and costs. Although social risks often cluster among individuals, no studies have examined associations between multiple social risks within the same individual. Our objec ... Full text Open Access Link to item Cite

Procedural Drift: An Underappreciated Element of Clinical Treatment Fidelity.

Journal Article J Orthop Sports Phys Ther · February 2022 Procedural fidelity involves delivering the correct guideline-supported treatment choice, in its designed manner, over the full care episode of the patient. Procedural drift is a subcomponent of procedural fidelity that involves performing the right treatm ... Full text Link to item Cite

What does it take to facilitate the integration of clinical practice guidelines for the management of low back pain into practice? Part 2: A strategic plan to activate dissemination.

Journal Article Pain Pract · January 2022 Low back pain (LBP) is the leading cause of disability worldwide among all musculoskeletal disorders despite an intense focus in research efforts. Researchers and decision makers have produced multiple clinical practice guidelines for the rehabilitation of ... Full text Link to item Cite

What is the believability of evidence that is read or heard by physical therapists?

Journal Article Braz J Phys Ther · 2022 BACKGROUND: Physical therapists obtain information from a variety of sources. The sources may influence their believability and use in clinical practice. OBJECTIVES: In this hypothesis-based study, we queried physical therapists (PTs) on the believability ... Full text Link to item Cite

Dysfunction of the stress response in individuals with persistent post-concussion symptoms: a scoping review

Journal Article Physical Therapy Reviews · January 1, 2022 Background: Preliminary evidence suggests that individuals with persistent post-concussion symptoms (PPCS) have a dysfunctional stress response, consisting of the autonomic nervous system (ANS) and hypothalamic pituitary adrenal-axis (HPA-axis). Objectives ... Full text Cite

Use of Non-Specific Knee Diagnoses and Incidence of Obscure Knee Injuries in a Large Government Health System.

Journal Article Clin Epidemiol · 2022 PURPOSE: Within a large government health system, to assess the practice of using non-specific diagnoses for knee disorders and determine how often they appear as the only diagnosis without more specificity. The secondary purpose was to identify the incide ... Full text Link to item Cite

Over time, evidence changes.

Journal Article Braz J Phys Ther · 2022 Full text Link to item Cite

Construct Validity and Item Response Theory Analysis of the PROMIS-29 v2.0 in Recipients of Lumbar Spine Surgery.

Journal Article Spine (Phila Pa 1976) · December 15, 2021 STUDY DESIGN: Observational cohort design involving measurement property assessment. OBJECTIVES: The aim of this study was to assess construct validity through hypothesis testing and to examine reliability and discrimination of the PROMIS-29 v2.0 using ite ... Full text Link to item Cite

Protocol for a multicenter, randomised controlled trial of surgeon-directed home therapy vs. outpatient rehabilitation by physical therapists for reverse total shoulder arthroplasty: the SHORT trial.

Journal Article Arch Physiother · December 10, 2021 BACKGROUND: Reverse total shoulder arthroplasty (RTSA) has emerged as a successful surgery with expanding indications. Outcomes may be influenced by post-operative rehabilitation; however, there is a dearth of research regarding optimal rehabilitation stra ... Full text Link to item Cite

Criterion validation and interpretability of the Single Assessment Numerical Evaluation (SANE) of self-reported recovery in patients with neck pain.

Journal Article Musculoskelet Sci Pract · December 2021 BACKGROUND: The SANE is a PROM of recovery, which may assist clinicians in clinical decision-making and discharge planning. The psychometric measurement properties of the SANE have yet to be determined for neck pain. OBJECTIVES: Threefold objectives includ ... Full text Link to item Cite

Five Recommendations to Address the Limitations of Patient-Reported Outcome Measures.

Journal Article J Orthop Sports Phys Ther · December 2021 Patient-reported outcome measures (PROMs) are reported by the patient and designed to capture patients' unique perspectives of their symptoms, quality of life, function, disability, and overall health status. Despite their important role in the health care ... Full text Link to item Cite

Delayed Rehabilitation Is Associated With Recurrence and Higher Medical Care Use After Ankle Sprain Injuries in the United States Military Health System.

Journal Article J Orthop Sports Phys Ther · December 2021 OBJECTIVE: To investigate the influence of time taken to begin musculoskeletal rehabilitation on injury recurrence and ankle-related medical care use at 1 year after ankle sprain. DESIGN: Retrospective cohort study of all beneficiaries of the US Military H ... Full text Link to item Cite

'Next steps' for researching orthopedic manual therapy.

Journal Article J Man Manip Ther · December 2021 Full text Link to item Cite

What does it take to facilitate the integration of clinical practice guidelines for the management of low back pain into practice? Part 1: A synthesis of recommendation.

Journal Article Pain Pract · November 2021 BACKGROUND: Despite the emergence of multiple clinical practice guidelines (CPGs) for the rehabilitation of low back pain (LBP) over the last decade, self-reported levels of disability in this population have not improved. This may be explained by the nume ... Full text Link to item Cite

Psychological, mobility, and satisfaction variables mediate the relationship between baseline back pain intensity and long-term outcomes in individuals who underwent lumbar spine surgery.

Journal Article Musculoskelet Sci Pract · October 2021 BACKGROUND: In patients who receive spine surgery, pain is relational to disability and quality of life, but exactly how this influence is mediated is not fully understood. Mediation analyses allow an understanding of a known relationship by exploring the ... Full text Link to item Cite

Diagnostic accuracy of upper limb neurodynamic tests in the diagnosis of cervical radiculopathy.

Journal Article Musculoskelet Sci Pract · October 2021 BACKGROUND: Upper limb neurodynamic tests (ULNT) are used to diagnose neuropathic conditions such as cervical radiculopathy (CR). Within the literature, a positive ULNT is defined in markedly variable ways, which is likely why the diagnostic accuracy of th ... Full text Link to item Cite

Student mental health and clinical education: exploring the DCE experience

Journal Article The Journal of Clinical Education in Physical Therapy · August 27, 2021 Purpose: There is a potential link between the clinical education phase of a physical therapist’s education and increased incidence of student mental health challenges. The Director of Clinical Education (DCE) has a complex role in supporting stude ... Full text Cite

The influence of a cognitive behavioural approach on changing patient expectations for conservative care in shoulder pain treatment: a protocol for a pragmatic randomized controlled trial.

Journal Article BMC Musculoskelet Disord · August 24, 2021 BACKGROUND: Despite similar outcomes for surgery and conservative care, the number of surgeries to treat rotator cuff related shoulder pain has increased. Interventions designed to enhance treatment expectations for conservative care have been shown to imp ... Full text Open Access Link to item Cite

Discharge destination influences risks of readmission and complications after lumbar spine surgery in severely disabled patients.

Journal Article Clin Neurol Neurosurg · August 2021 OBJECTIVE: For individuals with severe disability requiring spine surgery, appropriate discharge destination is a challenging and complex decision. Past studies have found associations between discharge destination and postoperative outcomes but were limit ... Full text Link to item Cite

True Differences in Poor Outcome Risks Between Revision and Primary Lumbar Spine Surgeries.

Journal Article HSS J · July 2021 Background: Previous studies have shown that the rates of complications associated with revision spine surgery are higher than those of primary spine surgery. However, there is a lack of research exploring the difference in magnitude of risk of poor outcom ... Full text Link to item Cite

Die Dämonisierung der Manuellen Therapie

Journal Article MSK – Muskuloskelettale Physiotherapie · July 2021 „Dämonisierung“ nennt der amerikanische Physiotherapeut und Professor Dr. Chad E. Cook die in den letzten Jahren lauter werdende Kritik an der Manuellen Therapie. Acht dieser „Dämonisierungen“ greift er auf und bewertet diese sorgfältig anhand der ... Full text Cite

Comparison of the accuracy of telehealth examination versus clinical examination in the detection of shoulder pathology.

Journal Article J Shoulder Elbow Surg · May 2021 HYPOTHESIS/BACKGROUND: In 2017, the American Orthopaedic Association advocated for the increased use of telehealth as an assessment and treatment platform, and demand has significantly increased during the coronavirus disease 2019 pandemic. Diagnostic effe ... Full text Link to item Cite

Providing value-based care as a physiotherapist.

Journal Article Arch Physiother · April 20, 2021 BACKGROUND: Despite millions spent in research funding, studies, and guidelines, outcomes involving musculoskeletal care continue to decline. The purpose of this Viewpoint is to describe value-based care and to suggest measures for its adoption by physioth ... Full text Link to item Cite

Manual Therapy in Preadolescent Children: A Delphi Investigation of Physical Therapists in the United States.

Journal Article Phys Ther · April 4, 2021 OBJECTIVE: Limited research has investigated the use of manual therapy to treat the preadolescent (0-12 years of age) population with musculoskeletal and neurological impairments. The purpose of this study was to identify the following among physical thera ... Full text Link to item Cite

The influence of prior opioid use on healthcare utilization and recurrence rates for non-surgical patients seeking initial care for patellofemoral pain.

Journal Article Clin Rheumatol · March 2021 INTRODUCTION/OBJECTIVES: Prior opioid use can influence outcomes for patients with musculoskeletal disorders. The purpose of this study was to compare downstream medical utilization-based outcomes (costs, visits, recurrent episodes) after an initial diagno ... Full text Link to item Cite

Adherence to Stepped Care for Management of Musculoskeletal Knee Pain Leads to Lower Health Care Utilization, Costs, and Recurrence.

Journal Article Am J Med · March 2021 OBJECTIVES: This study aimed to report compliance with stepped care management of patellofemoral pain and determine whether adherence to stepped care results in decreased recurrence and lower health care utilization. METHODS: A total of 60,730 participants ... Full text Link to item Cite

Factors associated with cervical arterial dysfunction: a survey of physical therapist educators in the United States.

Journal Article J Man Manip Ther · February 2021 Objectives: The purpose of this study was to identify the key constructs associated with symptom description and behavior, natural history of complaints, and previous medical history of cervical arterial dysfunction (CAD) according to a panel of physical t ... Full text Link to item Cite

Measurement Properties of the Oswestry Disability Index in Recipients of Lumbar Spine Surgery.

Journal Article Spine (Phila Pa 1976) · January 15, 2021 STUDY DESIGN: This is an observational study on the measurement properties of the Oswestry Disability Index (ODI) version 1.0. OBJECTIVES: To (1) determine the construct validity of the tool, specifically structural validity; (2) analyze the criterion vali ... Full text Open Access Link to item Cite

Long-term impact of obesity on patient-reported outcomes and patient satisfaction after lumbar spine surgery: an observational study.

Journal Article J Neurosurg Spine · January 1, 2021 OBJECTIVE: Obese body habitus is a challenging issue to address in lumbar spine surgery. There is a lack of consensus on the long-term influence of BMI on patient-reported outcomes and satisfaction. This study aimed to examine the differences in patient-re ... Full text Open Access Link to item Cite

Optimizing management of low back pain through the pain and disability drivers management model: A feasibility trial.

Journal Article PLoS One · 2021 INTRODUCTION: Self-reported levels of disability in individuals with low back pain (LBP) have not improved in the last decade. A broader perspective and a more comprehensive management framework may improve disability outcomes. We recently developed and va ... Full text Link to item Cite

Physician burnout and professional satisfaction in orthopedic surgeons during the COVID-19 Pandemic.

Journal Article Work · 2021 BACKGROUND: Burnout and professional satisfaction is an often an overlooked component for healthcare outcomes; the COVID-19 pandemic represents an unprecedented stressor that could contribute to higher levels of burnout. OBJECTIVES: Our primary objective w ... Full text Link to item Cite

The Influence of Unemployment and Disability Status on Clinical Outcomes in Patients Receiving Surgery for Low Back-Related Disorders: An Observational Study.

Journal Article Spine Surg Relat Res · 2021 INTRODUCTION: Employment status plays an essential role as a social determinant of health. Unemployed are more likely to have a longer length of hospital stay and a nearly twofold greater rate of 30 day readmission than those who were well employed at the ... Full text Open Access Link to item Cite

Dysfunction of the stress response in individuals with persistent post-concussion symptoms: a scoping review protocol

Journal Article Physical Therapy Reviews · January 1, 2021 Background: 10-15% of individuals who sustain a concussion develop persistent post-concussion symptoms (PPCS). Presently, there is no consensus regarding the pathophysiology of PPCS. Preliminary evidence suggests that individuals with PPCS have either a dy ... Full text Cite

What are the biopsychosocial risk factors associated with pain in postpartum runners? Development of a clinical decision tool.

Journal Article PLoS One · 2021 BACKGROUND: In 2019, a majority of runners participating in running events were female and 49% were of childbearing age. Studies have reported that women are initiating or returning to running after childbirth with up to 35% reporting pain. There are no st ... Full text Link to item Cite

Fractures and Chronic Recurrence are Commonly Associated with Ankle Sprains: a 5-year Population-level Cohort of Patients Seen in the U.S. Military Health System.

Journal Article Int J Sports Phys Ther · 2021 BACKGROUND: Whereas ankle-foot injuries are ubiquitous and affect ~16% of military service-members, granularity of information pertaining to ankle sprain subgroups and associated variables is lacking. The purpose of this study was to characterize and conte ... Full text Link to item Cite

Improving Veteran Access to Integrated Management of Back Pain (AIM-Back): Protocol for an Embedded Pragmatic Cluster-Randomized Trial.

Journal Article Pain Med · December 12, 2020 BACKGROUND: Coordinated efforts between the National Institutes of Health, the Department of Defense, and the Department of Veterans Affairs have built the capacity for large-scale clinical research investigating the effectiveness of nonpharmacologic pain ... Full text Open Access Link to item Cite

Effect of change in preoperative depression/anxiety on patient outcomes following lumbar spine surgery.

Journal Article Clin Neurol Neurosurg · December 2020 OBJECTIVE: The purpose of this study was to investigate the association between positive change in depression or anxiety within three months post-operation and clinically meaningful changes in long-term clinical outcomes after lumbar spine surgery. METHODS ... Full text Link to item Cite

Measurement properties of Patient-Reported Outcome Measures used to assess the sleep quality in adults with high prevalence chronic pain conditions: a systematic review.

Journal Article Sleep Med · October 2020 OBJECTIVES: To provide a comprehensive overview of the measurement properties of patient-reported outcome measures (PROMs) used to assess sleep quality in adult patients with prevalent pain-related conditions. METHODS: Without language restrictions PubMed, ... Full text Link to item Cite

Predictors of research productivity among physical therapy programs in the United States: an observational study.

Journal Article BMC Med Educ · July 11, 2020 BACKGROUND: This study targeted the association of program characteristics of 203 Doctor of Physical Therapy (DPT) programs in the United States (US) reported by the Commission on Accreditation in Physical Therapy Education (CAPTE) in their 2017 Annual Acc ... Full text Link to item Cite

The Effectiveness of Virtual Reality in Patients With Spinal Pain: A Systematic Review and Meta-Analysis.

Journal Article Pain Pract · July 2020 BACKGROUND: Virtual reality (VR) technologies have been shown to be beneficial in various areas of health care; to date, there are no systematic reviews examining the effectiveness of VR technology for the treatment of spinal pain. PURPOSE: To investigate ... Full text Link to item Cite

Harms and benefits of opioids for management of non-surgical acute and chronic low back pain: a systematic review.

Journal Article Br J Sports Med · June 2020 BACKGROUND: Consequences of prescription opioid use involve harms, addiction, tolerance and death. Despite routine prescription, opioids are not recommended for initial intervention by any major multidisciplinary low back pain (LBP) guideline. OBJECTIVE: O ... Full text Link to item Cite

Post-randomization bias.

Journal Article J Man Manip Ther · May 2020 Full text Link to item Cite

Operationalization of the new Pain and Disability Drivers Management model: A modified Delphi survey of multidisciplinary pain management experts.

Journal Article J Eval Clin Pract · February 2020 BACKGROUND: We recently proposed the Pain and Disability Drivers Management (PDDM) model, which was designed to outline comprehensive factors driving pain and disability in low back pain (LBP). Although we have hypothesized and proposed 41 elements, which ... Full text Link to item Cite

Higher order thinking about differential diagnosis.

Journal Article Braz J Phys Ther · 2020 BACKGROUND: Differential diagnosis is a systematic process used to identify the proper diagnosis from a set of possible competing diagnoses. METHODS: The goal of this masterclass is to discuss the higher order thinking components of differential diagnosis. ... Full text Link to item Cite

Do older adults with shoulder disorders who meet the minimal clinically important difference also present low disability at discharge? An observational study.

Journal Article Braz J Phys Ther · 2020 BACKGROUND: The choice of outcome success thresholds may influence clinical management, pay-for-performance, and assessment of value-based care. OBJECTIVE: To evaluate outcomes success thresholds in older adults using two different methods: 1) Minimal clin ... Full text Link to item Cite

Systematic review of diagnostic accuracy of patient history, clinical findings, and physical tests in the diagnosis of lumbar spinal stenosis.

Journal Article Eur Spine J · January 2020 PURPOSE: To update evidence of diagnostic potential for identification of lumbar spinal stenosis (LSS) based on demographic and patient history, clinical findings, and physical tests, and report posttest probabilities associated with test findings. METHODS ... Full text Open Access Link to item Cite

The Elephant in the Room: Too Much Medicine in Musculoskeletal Practice.

Journal Article J Orthop Sports Phys Ther · January 2020 While advances in assessment and management of musculoskeletal conditions have improved care for many people, there have been other, less beneficial developments in the provision of care for people with musculoskeletal pain conditions, one of which is the ... Full text Link to item Cite

Clinical examination factors that predict delayed recovery in individuals with concussion.

Journal Article Arch Physiother · 2020 BACKGROUND: Risk factors for prolonged recovery after concussion have been well researched, but specific objective clinical examination findings have not. This study examined whether clinical examination results could predict delayed recovery (DR) in indiv ... Full text Open Access Link to item Cite

The Risk of Prior Opioid Exposure on Future Opioid Use and Comorbidities in Individuals With Non-Acute Musculoskeletal Knee Pain.

Journal Article J Prim Care Community Health · 2020 OBJECTIVES: Due to their potentially deleterious effects, minimizing the use of opioids for musculoskeletal pain is a priority for healthcare systems. The objective of this study was to examine the risk of future opioid prescription use based on prior opio ... Full text Link to item Cite

Reliability, Validity, and Factor Structure of Pittsburgh Sleep Quality Index in Community-Based Centenarians.

Journal Article Front Psychiatry · 2020 BACKGROUND: The Pittsburgh Sleep Quality Index (PSQI) is a widely used self-report questionnaire that measures general sleep quality in general populations. However, its psychometric properties have yet to be thoroughly examined in longevous persons. OBJEC ... Full text Link to item Cite

Patients' perceptions with musculoskeletal disorders regarding their experience with healthcare providers and health services: an overview of reviews.

Journal Article Arch Physiother · 2020 OBJECTIVES: This overview of reviews aimed to identify (1) aspects of the patient experience when seeking care for musculoskeletal disorders from healthcare providers and the healthcare system, and (2) which mechanisms are used to measure aspects of the pa ... Full text Link to item Cite

Quantifying the collective influence of social determinants of health using conditional and cluster modeling.

Journal Article PLoS One · 2020 OBJECTIVES: Our objective was to analyze the collective effect of social determinants of health (SDoH) on lumbar spine surgery outcomes utilizing two different statistical methods of combining variables. METHODS: This observational study analyzed data from ... Full text Link to item Cite

Common musculoskeletal impairments in postpartum runners: an international Delphi study.

Journal Article Arch Physiother · 2020 BACKGROUND: Postpartum runners report musculoskeletal pain with running. Because of inadequate research, little is known about the origin and pain-related classification. Through expert consensus, this study is the first attempt to understand the musculosk ... Full text Link to item Cite

Concurrent validity of the single assessment numerical evaluation and patient-reported functional measures in patients with musculoskeletal disorders: An observational study.

Journal Article Musculoskelet Sci Pract · December 2019 INTRODUCTION: As patient-reported outcome measures (PROMs) continue to evolve as vital measures of patient status, it may be useful to identify efficiently, Single Assessment Numeric Evaluation (SANE) scores that are valid and related to the patient's spec ... Full text Link to item Cite

Social Determinants of Health: If You Aren't Measuring Them, You Aren't Seeing the Big Picture.

Journal Article J Orthop Sports Phys Ther · December 2019 Clinicians often assume that interventions directly influence the recovery of patients with musculoskeletal impairments. In reality, other factors may influence recovery more than the direct treatment provided. The most powerful factor may be upstream effe ... Full text Link to item Cite

Which patients do not seek additional medical care after a self-management class for low back pain? An observational cohort.

Journal Article Clin Rehabil · November 2019 OBJECTIVES: (1) To identify baseline variables associated with patients that sought no additional care during the 12 months following a single self-management education session for low back pain (LBP), and (2) in those who sought care, to determine whether ... Full text Link to item Cite

Concurrent validity of a low-cost and time-efficient clinical sensory test battery to evaluate somatosensory dysfunction.

Journal Article Eur J Pain · November 2019 BACKGROUND: This study describes a low-cost and time-efficient clinical sensory test (CST) battery and evaluates its concurrent validity as a screening tool to detect somatosensory dysfunction as determined using quantitative sensory testing (QST). METHOD: ... Full text Link to item Cite

Diagnostic utility of the Active Compression Test for the superior labrum anterior posterior tear: A systematic review.

Journal Article Shoulder Elbow · October 2019 BACKGROUND: The Active Compression Test has been proposed to have high diagnostic accuracy for superior labrum anterior to posterior tears. The aim of this systematic review was to compile the available evidence for this test and evaluate its diagnostic ac ... Full text Link to item Cite

Do prognostic variables predict a set of outcomes for patients with chronic low back pain: a long-term follow-up secondary analysis of a randomized control trial.

Journal Article J Man Manip Ther · September 2019 Objective: The objective was to explore for universal prognostic variables, or predictors, across three different outcome measures in patients with chronic low back pain (LBP). We hypothesized that selected prognostic variables would be 'universal' prognos ... Full text Link to item Cite

Comorbid Insomnia and Sleep Apnea are Associated with Greater Downstream Health Care Utilization and Chronic Opioid Use after Arthroscopic Hip Surgery.

Journal Article Pain Physician · July 2019 BACKGROUND: There is a relationship between sleep, pain, and chronic opioid utilization. This has been poorly explored in general, and especially in patients undergoing orthopaedic surgery. Fewer studies have investigated this relationship based on a sleep ... Link to item Cite

Comorbidities in the first 2 years after arthroscopic hip surgery: substantial increases in mental health disorders, chronic pain, substance abuse and cardiometabolic conditions.

Journal Article Br J Sports Med · May 2019 OBJECTIVES: We aimed to identify the rate of seven comorbidities (mental health disorders, chronic pain, substance abuse disorders, cardiovascular disorders, metabolic syndrome, systemic arthropathy and sleep disorders) that occurred within 2 years after h ... Full text Link to item Cite

Reliability and relationship of the fear-avoidance beliefs questionnaire with the shoulder pain and disability index and numeric pain rating scale in patients with shoulder pain.

Journal Article Physiother Theory Pract · May 2019 PURPOSE: The purpose of this study was to determine: 1) the test-retest reliability of Fear-Avoidance Beliefs Questionnaire (FABQ) Work (FABQW) subscale, FABQ Physical Activity (FABQPA) subscale, Shoulder Pain and Disability Index (SPADI) Pain subscale, SP ... Full text Link to item Cite

Differences in Characteristics and Downstream Drug Use Among Opioid-Naïve and Prior Opioid Users with Low Back Pain.

Journal Article Pain Pract · February 2019 BACKGROUND: Recent clinical practice guidelines have suggested conservative treatment approaches, including physical therapy, are indicated as first-line treatment for patients with low back pain (LBP); however, LBP continues to be managed with opioids, de ... Full text Link to item Cite

Explanatory multivariate modeling for disability, pain, and claims in patients with spine pain via a physical therapy direct access model of care.

Journal Article J Back Musculoskelet Rehabil · 2019 BACKGROUND: Direct access physical therapy (DAPT) may result in improved patient outcomes and reduced healthcare costs. Prognostic factors associated with spine-related outcomes and insurance claims with DAPT are needed. OBJECTIVE: To identify factors that ... Full text Link to item Cite

Concurrent validity of a patient self-administered examination and a clinical examination for femoroacetabular impingement syndrome.

Journal Article BMJ Open Sport Exerc Med · 2019 OBJECTIVE: Telehealth has been established as a viable option for improved access and timeliness of care. Physician-guided patient self-evaluation may improve the viability of telehealth evaluation; however, there are little data evaluating the efficacy of ... Full text Link to item Cite

Do alterations in muscle strength, flexibility, range of motion, and alignment predict lower extremity injury in runners: a systematic review.

Journal Article Arch Physiother · 2019 BACKGROUND: Injury is common in running and seen to impact up to 94% of recreational runners. Clinicians often use alterations from normal musculoskeletal clinical assessments to assess for risk of injury, but it is unclear if these assessments are associa ... Full text Link to item Cite

Association of Early Physical Therapy With Long-term Opioid Use Among Opioid-Naive Patients With Musculoskeletal Pain.

Journal Article JAMA Netw Open · December 7, 2018 IMPORTANCE: Nonpharmacologic methods of reducing the risk of new chronic opioid use among patients with musculoskeletal pain are important given the burden of the opioid epidemic in the United States. OBJECTIVE: To determine the association between early p ... Full text Link to item Cite

Clinimetric Testing of the Lumbar Spine Instability Questionnaire.

Journal Article J Orthop Sports Phys Ther · December 2018 BACKGROUND: The Lumbar Spine Instability Questionnaire (LSIQ) is a self-report measure of 15 items. Previous studies have used the LSIQ as a measure of clinical instability; however, a comprehensive evaluation of its clinimetric properties has not been con ... Full text Link to item Cite

Chronic diabetic peripheral neuropathic pain: psychometric properties of pain and physical function outcome measures

Journal Article Physical Therapy Reviews · November 2, 2018 Background: Diabetic peripheral neuropathy (DPN) not only produces severe pain, tingling, and numbness sensation in the involved limbs, but also limits physical function due to loss of sensation. There are no recommended methods for clinical situations to ... Full text Cite

Does Health Care Utilization Before Hip Arthroscopy Predict Health Care Utilization After Surgery in the US Military Health System? An Investigation Into Health-Seeking Behavior.

Journal Article J Orthop Sports Phys Ther · November 2018 BACKGROUND: The influence of prior patterns of health care utilization on future health care utilization has had minimal investigation in populations with musculoskeletal disorders. OBJECTIVES: The purpose of this study was to explore the relationship betw ... Full text Link to item Cite

Manual Therapy Cures Death: I Think I Read That Somewhere.

Journal Article J Orthop Sports Phys Ther · November 2018 Predatory journals are compromising the scientific credibility of "published" research. Past concerns with predatory journals have included the lack of a peer-review process, lack of an editorial board, and little to no description of the publication's eth ... Full text Link to item Cite

Getting the most out of intensive longitudinal data: a methodological review of workload-injury studies.

Journal Article BMJ Open · October 2, 2018 OBJECTIVES: To systematically identify and qualitatively review the statistical approaches used in prospective cohort studies of team sports that reported intensive longitudinal data (ILD) (>20 observations per athlete) and examined the relationship betwee ... Full text Link to item Cite

Preliminary reliability and validity of the shoulder functional reach score.

Journal Article Physiother Res Int · October 2018 OBJECTIVE: The purpose of this study was to determine (a) if the newly developed shoulder functional reach score (SFRS) is reliable; (b) if the SFRS demonstrates construct validity by being able to differentiate between patients' symptomatic and asymptomat ... Full text Link to item Cite

The impact of pragmatic vs. prescriptive study designs on the outcomes of low back and neck pain when using mobilization or manipulation techniques: a systematic review and meta-analysis.

Journal Article J Man Manip Ther · July 2018 OBJECTIVE: The purpose of this systematic review and meta-analysis was to examine the impact of pragmatic versus prescriptive study designs on the outcomes of low back and neck pain when using mobilization or manipulation techniques. METHODS: This study de ... Full text Link to item Cite

Comparison of Downstream Health Care Utilization, Costs, and Long-Term Opioid Use: Physical Therapist Management Versus Opioid Therapy Management After Arthroscopic Hip Surgery.

Journal Article Phys Ther · May 1, 2018 BACKGROUND: Physical therapy and opioid prescriptions are common after hip surgery, but are sometimes delayed or not used. OBJECTIVE: The objective of this study was to compare downstream health care utilization and opioid use following hip surgery for dif ... Full text Link to item Cite

Measurement Properties of the Central Sensitization Inventory: A Systematic Review.

Journal Article Pain Pract · April 2018 BACKGROUND AND OBJECTIVE: Central sensitization (CS) is a phenomenon associated with several medical diagnoses, including postcancer pain, low back pain, osteoarthritis, whiplash, and fibromyalgia. CS involves an amplification of neural signaling within th ... Full text Link to item Cite

Red flag screening for low back pain: nothing to see here, move along: a narrative review.

Journal Article Br J Sports Med · April 2018 Screening for red flags in individuals with low back pain (LBP) has been a historical hallmark of musculoskeletal management. Red flag screening is endorsed by most LBP clinical practice guidelines, despite a lack of support for their diagnostic capacity. ... Full text Link to item Cite

Physical examination of dizziness in athletes after a concussion: A descriptive study.

Journal Article Musculoskelet Sci Pract · April 2018 BACKGROUND: Dizziness is commonly reported after concussion. With the forces experienced at the time of the injury, several anatomical locations may have been altered, causing dizziness. OBJECTIVE: Describe an objective examination and the types of impairm ... Full text Link to item Cite

The association of discharge destination with 30-day rehospitalization rates among older adults receiving lumbar spinal fusion surgery.

Journal Article Musculoskelet Sci Pract · April 2018 BACKGROUND: As defined by Medicare (United States), post-acute rehabilitation services include care provided in inpatient rehabilitation units and facilities, skilled nursing facilities, long-term acute hospitals, and by home health services. METHODS: We r ... Full text Link to item Cite

The efficacy of stretching exercises to reduce posterior shoulder tightness acutely in the postoperative population: a single blinded randomized controlled trial.

Journal Article Physiother Theory Pract · February 2018 BACKGROUND: Posterior shoulder tightness (PST) is a postoperative complication leading to pain, impaired mobility, and reduced function. Despite the potential morbidity associated with PST, no studies have investigated the efficacy of shoulder-stretching m ... Full text Link to item Cite

The Influence of Patient Choice of First Provider on Costs and Outcomes: Analysis From a Physical Therapy Patient Registry.

Journal Article J Orthop Sports Phys Ther · February 2018 Study Design Retrospective study. Background Alternative models of care that allow patients to choose direct access to physical therapy have shown promise in terms of cost reduction for neck and back pain. However, real-world exploration within the US heal ... Full text Link to item Cite

Identifying risk factors for first-episode neck pain: A systematic review.

Journal Article Musculoskelet Sci Pract · February 2018 Neck pain affects 15.1% of the United States' general population every 3 months, and ranks fourth in global disability. Because of the tendency for neck pain to become a chronic issue, it is important to identify risk factors that could encourage preventio ... Full text Link to item Cite

Leveraging healthcare utilization to explore outcomes from musculoskeletal disorders: methodology for defining relevant variables from a health services data repository.

Journal Article BMC Med Inform Decis Mak · January 31, 2018 BACKGROUND: Large healthcare databases, with their ability to collect many variables from daily medical practice, greatly enable health services research. These longitudinal databases provide large cohorts and longitudinal time frames, allowing for highly ... Full text Link to item Cite

Benefits and Threats to Using Social Media for Presenting and Implementing Evidence.

Journal Article J Orthop Sports Phys Ther · January 2018 As a potential high-yield tool for disseminating information that can reach many people, social media is transforming how clinicians, the public, and policy makers are educated and find new knowledge associated with research-related information. Social med ... Full text Link to item Cite

Physical therapists familiarity and beliefs about health services utilization and health seeking behaviour.

Journal Article Braz J Phys Ther · 2018 BACKGROUND: Physical therapists' familiarity, perceptions, and beliefs about health services utilization and health seeking behaviour have not been previously assessed. OBJECTIVES: The purposes of this study were to identify physical therapists' characteri ... Full text Open Access Link to item Cite

What Constitutes Academic Dishonesty in Physical Therapy Education: Do Faculty and Learners Agree?

Journal Article J Allied Health · 2018 BACKGROUND: Academic dishonesty (AD) has been widely reported as an increasing concern in higher education. The primary purpose of the current study was to investigate the perceptions of what faculty and learners consider acts of AD and the level of seriou ... Link to item Cite

What Traits Are Reflective of Positive Professional Performance in Physical Therapy Program Graduates? A Delphi Study.

Journal Article J Allied Health · 2018 BACKGROUND: Physical therapist program level successes have been associated with cognitive and noncognitive predictors. To our knowledge, no studies in physical therapy have explored predictive criteria for positive professional performance (PPP) in one's ... Link to item Cite

Health seeking behavior as a predictor of healthcare utilization in a population of patients with spinal pain.

Journal Article PLoS One · 2018 BACKGROUND: The global burden of low back pain is growing rapidly, accompanied by increasing rates of associated healthcare utilization. Health seeking behavior (HSB) has been suggested as a mediator of healthcare utilization. The aims of this study were t ... Full text Link to item Cite

Variables Describing Individuals With Improved Pain and Function With a Primary Complaint of Low Back Pain: A Secondary Analysis.

Journal Article J Manipulative Physiol Ther · 2018 OBJECTIVES: The purpose of this study was to identify descriptive factors in individuals with a primary complaint of low back pain (LBP) associated with improved pain and function after receiving physical therapy for LBP with or without manual therapy and ... Full text Link to item Cite

A novel tool for evaluating non-cognitive traits of doctor of physical therapy learners in the United States.

Journal Article J Educ Eval Health Prof · 2018 PURPOSE: The primary aim of this study was to develop a survey addressing an individual's non-cognitive traits, such as emotional intelligence, interpersonal skills, social intelligence, psychological flexibility, and grit. Such a tool would provide benefi ... Full text Link to item Cite

Predictors of chronic prescription opioid use after orthopedic surgery: derivation of a clinical prediction rule.

Journal Article Perioper Med (Lond) · 2018 BACKGROUND: Prescription opioid use at high doses or over extended periods of time is associated with adverse outcomes, including dependency and abuse. The aim of this study was to identify mediating variables that predict chronic opioid use, defined as th ... Full text Link to item Cite

Treatment effectiveness and fidelity of manual therapy to the knee: A systematic review and meta-analysis.

Journal Article Musculoskeletal Care · September 2017 Manual therapy (MT) is a commonly used treatment for knee osteoarthritis (OA) but to date only one systematic review has explored its effectiveness. The purpos e of the present study was to perform a systematic review and meta-analysis of the literature, t ... Full text Link to item Cite

Diagnostic Accuracy of Imaging Modalities and Injection Techniques for the Diagnosis of Femoroacetabular Impingement/Labral Tear: A Systematic Review With Meta-analysis.

Journal Article Am J Sports Med · September 2017 BACKGROUND: Diagnosing femoroacetabular impingement/acetabular labral tear (FAI/ALT) and subsequently making a decision regarding surgery are based primarily on diagnostic imaging and intra-articular hip joint injection techniques of unknown accuracy. PURP ... Full text Link to item Cite

Does early change predict long-term (6 months) improvements in subjects who receive manual therapy for low back pain?

Journal Article Physiother Theory Pract · September 2017 Early change is commonly assessed for manual therapy interventions and has been used to determine treatment appropriateness. However, current studies have only explored the relationship of between or within-session changes and short-/medium-term outcomes. ... Full text Link to item Cite

Effects of manual therapy and exercise targeting the hips in patients with low-back pain-A randomized controlled trial.

Journal Article J Eval Clin Pract · August 2017 RATIONALE: The benefits of providing manual therapy and exercise targeting the hips in individuals with mechanical low-back pain (LBP) are not well established. OBJECTIVES: The objective in this study is to determine whether a formal prescriptive treatment ... Full text Link to item Cite

Does shared decision making results in better health related outcomes for individuals with painful musculoskeletal disorders? A systematic review.

Journal Article J Man Manip Ther · July 2017 Background: Shared Decision-Making (SDM) is a dynamic process by which the health care professional and the patient influence each other in making health-related choices or decisions. SDM is strongly embedded in today's health care approaches, and is advoc ... Full text Link to item Cite

Clinical Outcome Measures for Lateropulsion Poststroke: An Updated Systematic Review.

Journal Article J Neurol Phys Ther · July 2017 BACKGROUND AND PURPOSE: Contraversive Lateropulsion, also referred to as contraversive pushing, pusher behavior, and pusher syndrome, can be associated with increased hospital length of stay, increased health care costs, and delayed outcomes in persons wit ... Full text Link to item Cite

Risk Stratification for 4,837 Individuals with Knee Pain Who Receive Physical Therapy Treatment.

Journal Article Musculoskeletal Care · June 2017 Risk stratification is a modelling method that is designed to target interventions toward patients with specific needs. The objective of the present study was to identify predictive characteristics related to patients with knee impairments who had a high r ... Full text Link to item Cite

Influence of perioperative complication severity on 1- and 2-year outcomes of low back surgery.

Journal Article J Orthop Traumatol · June 2017 BACKGROUND: Several factors potentially influence outcomes of surgery, including perioperative complications. Complications may take many forms and the Clavien-Dindo (CD) classification is designed to categorize them by degree of severity. The aim of this ... Full text Link to item Cite

Important clinical descriptors to include in the examination and assessment of patients with femoroacetabular impingement syndrome: an international and multi-disciplinary Delphi survey.

Journal Article Knee Surg Sports Traumatol Arthrosc · June 2017 PURPOSE: Determine which examination findings are key clinical descriptors of femoroacetabular impingement syndrome (FAIS) through use of an international, multi-disciplinary expert panel. METHODS: A three-round Delphi survey utilizing an international, mu ... Full text Link to item Cite

Psychological Predictors of Outcomes with Lumbar Spinal Fusion: A Systematic Literature Review.

Journal Article Physiother Res Int · April 2017 PURPOSE: To review the predictive/risk psychological factors at baseline that are associated with a favourable (or non-favourable) outcome following lumbar spinal fusion (LSF). METHODS: A computer-assisted literature search of PubMed, CINAHL complete and E ... Full text Open Access Link to item Cite

Risk stratification of patients with shoulder pain seen in physical therapy practice.

Journal Article J Eval Clin Pract · April 2017 RATIONALE, AIMS AND OBJECTIVES: Musculoskeletal shoulder pain is commonly treated in physical therapy. There is inconsistency in the literature regarding patient characteristics related to prognosis. Having prognostic information could be useful for improv ... Full text Link to item Cite

Post-operative opioid pain management patterns for patients who receive hip surgery.

Journal Article Subst Abuse Treat Prev Policy · March 16, 2017 BACKGROUND: Identifying optimal, post-operative opioid management strategies is a priority of health providers and government agencies. At present, there are no studies we are aware of that have formally investigated opioid prescribing patterns for post-op ... Full text Open Access Link to item Cite

Rehabilitation management of low back pain - it's time to pull it all together!

Journal Article J Pain Res · 2017 In the past, rehabilitation research initiatives for low back pain (LBP) have targeted outcome enhancement through personalized treatment approaches, namely through classification systems (CS). Although the use of CS has enhanced outcomes, common managemen ... Full text Link to item Cite

Predatory Journals: The Worst Thing in Publishing, Ever.

Journal Article J Orthop Sports Phys Ther · January 2017 Viewpoint co-editor Chad Cook shares his experience with predatory journals. J Orthop Sports Phys Ther 2017;47(1):1-2. doi:10.2519/jospt.2017.0101. ... Full text Link to item Cite

Clinical guidelines for low back pain: A critical review of consensus and inconsistencies across three major guidelines.

Journal Article Best Pract Res Clin Rheumatol · December 2016 Given the scale and cost of the low back pain problem, it is imperative that healthcare professionals involved in the care of people with low back pain have access to up-to-date, evidence-based information to assist them in treatment decision-making. Clini ... Full text Link to item Cite

Scapulothoracic Muscle Strength Changes Following a Single Session of Manual Therapy and an Exercise Programme in Subjects with Neck Pain.

Journal Article Musculoskeletal Care · December 2016 INTRODUCTION: Scapulothoracic muscle weakness has been associated with neck pain (NP). Little evidence exists regarding lower trapezius (LT), middle trapezius (MT) and serratus anterior (SA) strength in this population. LT strength changes have been observ ... Full text Link to item Cite

Physical performance tests predict injury in National Collegiate Athletic Association athletes: a three-season prospective cohort study.

Journal Article Br J Sports Med · November 2016 BACKGROUND: The ability to predict injury is difficult. Prior injury is the only risk factor that has been reported consistently in multiple research studies. Convenient and easy to perform, physical performance tests (PPTs) have great allure as prognostic ... Full text Link to item Cite

The diagnostic credibility of second impact syndrome: A systematic literature review.

Journal Article J Sci Med Sport · October 2016 OBJECTIVES: The purpose of this review was to examine current literature to determine whether or not enough evidence exists to support a World Health Organization (WHO) recognized ICD-10 case definition for Second Impact Syndrome (SIS). DESIGN: Systematic ... Full text Link to item Cite

Does physiotherapy diagnosis of shoulder pathology compare to arthroscopic findings?

Journal Article Br J Sports Med · September 2016 AIMS: To explore the ability of a physiotherapist, using a standardised musculoskeletal physiotherapy assessment protocol, to accurately identify the structures potentially responsible for shoulder symptoms against a standardised arthroscopic shoulder diag ... Full text Link to item Cite

Scapulothoracic muscle strength in individuals with neck pain.

Journal Article J Back Musculoskelet Rehabil · August 10, 2016 BACKGROUND: People with neck pain often present with weakness in the scapulothoracic muscles. Few studies have examined lower trapezius (LT), middle trapezius (MT) and serratus anterior (SA) muscle strength in individuals with neck pain, nor compared stren ... Full text Link to item Cite

Pain and Physical Functioning in Neuropathic Pain: A Systematic Review of Psychometric Properties of Various Outcome Measures.

Journal Article Pain Pract · April 2016 INTRODUCTION: A range of outcome measures across various domains are used to evaluate change following an intervention in clinical trials on chronic neuropathic pain (NeP). However, to capture a real change in the variable of interest, the psychometric pro ... Full text Link to item Cite

A Prescriptively Selected Nonthrust Manipulation Versus a Therapist-Selected Nonthrust Manipulation for Treatment of Individuals With Low Back Pain: A Randomized Clinical Trial.

Journal Article J Orthop Sports Phys Ther · April 2016 STUDY DESIGN: Randomized controlled trial. BACKGROUND: Several studies that have investigated the effects of a therapist-selected versus a randomly assigned segmental approach have looked at immediate effects only for pain-related outcomes. OBJECTIVES: To ... Full text Link to item Cite

Improving the Reporting of Studies Using Routinely Collected Health Data in Physical Therapy.

Journal Article J Orthop Sports Phys Ther · March 2016 Reporting guidelines have been developed to improve the reporting of research, with the explicit aims that readers of research should understand what was planned, what was done, and what was found. The Strengthening of Reporting of Observational Studies in ... Full text Link to item Cite

Physical examination tests for screening and diagnosis of cervicogenic headache: A systematic review.

Journal Article Man Ther · February 2016 It has been suggested that differential diagnosis of headaches should consist of a robust subjective examination and a detailed physical examination of the cervical spine. Cervicogenic headache (CGH) is a form of headache that involves referred pain from t ... Full text Link to item Cite

Do Differences in Programmatic Resource Investments Result in Different 3-Year Pass Rates on the U.S. National Physical Therapy Examination?

Journal Article J Allied Health · 2016 PURPOSE: The rising cost of health professions education is well documented and a growing concern among educators; however, little is known about the implications of resource investment on student success. The objective of this study was to determine wheth ... Link to item Cite

Selectivity of physiotherapist programs in the United States does not differ by institutional funding source or research activity level.

Journal Article J Educ Eval Health Prof · 2016 PURPOSE: This study aimed to compare selectivity characteristics among institution characteristics to determine differences by institutional funding source (public vs. private) or research activity level (research vs. non-research). METHODS: This study inc ... Full text Open Access Link to item Cite

Does emotional intelligence influence success during medical school admissions and program matriculation?: a systematic review.

Journal Article J Educ Eval Health Prof · 2016 PURPOSE: It aimed at determining whether emotional intelligence is a predictor for success in a medical school program and whether the emotional intelligence construct correlated with other markers for admission into medical school. METHODS: Three database ... Full text Link to item Cite

Lumbar radiculopathy

Chapter · 2016 Cite

Risk stratification of patients with low back pain seen in physical therapy practice.

Journal Article Man Ther · December 2015 DESIGN: A secondary analysis of a retrospective cohort was conducted using data obtained from a commercial outcomes database. OBJECTIVE: To identify predictive characteristics related to patients with lumbar impairments who have a high risk of a bad progno ... Full text Link to item Cite

The effect of manual therapy with augmentative exercises for neck pain: a randomised clinical trial.

Journal Article J Man Manip Ther · December 2015 OBJECTIVES: To compare the effect of manual therapy (MT) and an augmentative exercise programme (AEP) versus MT and general neck range of motion (ROM) on functional outcomes for patients with neck pain. A secondary objective was to examine changes in self- ... Full text Link to item Cite

Differential diagnosis of dizziness after a sports-related concussion based on descriptors and triggers: an observational study.

Journal Article Inj Epidemiol · December 2015 BACKGROUND: Dizziness is often reported after a sports-related concussion. Forces experienced at the time of the concussion can cause an injury to multiple anatomical areas, including the central nervous system, the vestibular system, and the cervical spin ... Full text Link to item Cite

Predictors of pain and disability outcomes in one thousand, one hundred and eight patients who underwent lumbar discectomy surgery.

Journal Article Int Orthop · November 2015 BACKGROUND: A key component toward improving surgical outcomes is proper patient selection. Improved selection can occur through exploration of prognostic studies that identify variables which are associated with good or poorer outcomes with a specific int ... Full text Link to item Cite

Older Age and Leg Pain Are Good Predictors of Pain and Disability Outcomes in 2710 Patients Who Receive Lumbar Fusion.

Journal Article HSS J · October 2015 BACKGROUND: Identifying appropriate candidates for lumbar spine fusion is a challenging and controversial topic. The purpose of this study was to identify baseline characteristics related to poor/favorable outcomes at 1 year for a patient who received lumb ... Full text Link to item Cite

Scholarly research productivity is not related to higher three-year licensure pass rates for physical therapy academic programs.

Journal Article BMC Med Educ · September 11, 2015 BACKGROUND: In the domain of academia, the scholarship of research may include, but not limited to, peer-reviewed publications, presentations, or grant submissions. Programmatic research productivity is one of many measures of academic program reputation a ... Full text Open Access Link to item Cite

A Preliminary Risk Stratification Model for Individuals with Neck Pain.

Journal Article Musculoskeletal Care · September 2015 INTRODUCTION: The aim of the present study was to identify predictive characteristics related to patients with neck impairments who have a high risk of a poor prognosis (lowest functional recovery compared to visit utilization) as well as those who are at ... Full text Link to item Cite

The diagnostic utility of clinical tests for differentiating between cervicogenic and other causes of dizziness after a sports-related concussion: An international Delphi study.

Journal Article J Sci Med Sport · July 2015 OBJECTIVES: Dizziness after a sports-related concussion is very common and is associated with prolonged recovery. The events in sports that cause concussion include strong mechanical forces exerted to the head and neck, potentially injuring the cervical re ... Full text Link to item Cite

Diagnostic accuracy of clinical tests for the diagnosis of hip femoroacetabular impingement/labral tear: a systematic review with meta-analysis.

Journal Article Br J Sports Med · June 2015 BACKGROUND: Surgery for hip femoroacetabular impingement/acetabular labral tear (FAI/ALT) is exponentially increasing despite lacking investigation of the accuracy of various diagnostic measures. Useful clinical utility of these measures is necessary to su ... Full text Link to item Cite

The relationship between chief complaint and comparable sign in patients with spinal pain: An exploratory study.

Journal Article Man Ther · June 2015 Many musculoskeletal management philosophies advocate the exploration of the relationship between the patient's chief complaint (CC) and the physical examination findings that reproduce/reduce/change that CC. Geoffrey Maitland developed the concept "compar ... Full text Link to item Cite

Clinician-friendly lower extremity physical performance measures in athletes: a systematic review of measurement properties and correlation with injury, part 1. The tests for knee function including the hop tests.

Journal Article Br J Sports Med · May 2015 OBJECTIVE: To review the measurement properties of physical performance tests (PPTs) of the knee as each pertain to athletes, and to determine the relationship between PPTs and injury in athletes age 12 years to adult. METHODS: A search strategy was constr ... Full text Link to item Cite

Clinician-friendly lower extremity physical performance tests in athletes: a systematic review of measurement properties and correlation with injury. Part 2--the tests for the hip, thigh, foot and ankle including the star excursion balance test.

Journal Article Br J Sports Med · May 2015 OBJECTIVE: To review the quality of literature and measurement properties of physical performance tests (PPTs) of the lower extremity in athletes. METHODS: Using the PICOS method we established our research question as to whether individual PPTs of the low ... Full text Link to item Cite

Risk factors associated with sacral stress fractures: A systematic review

Journal Article Journal of Manual and Manipulative Therapy · May 1, 2015 Objectives: The objective of this study was to examine and identify risk factors associated with the development of sacral stress fractures in order to improve diagnosis in clinical practice. Methods: Electronic search strategies in PubMed, CINAHL, Scopus, ... Full text Cite

Physical examination tests for hip dysfunction and injury.

Journal Article Br J Sports Med · March 2015 BACKGROUND: Physical examination tests for hip dysfunction and injury of the strongest diagnostic accuracy were identified in a recent systematic review with meta-analysis in BJSM. These tests are described in this article. DISCUSSION: A detailed descripti ... Full text Link to item Cite

Modifiable variables in physical therapy education programs associated with first-time and three-year National Physical Therapy Examination pass rates in the United States.

Journal Article J Educ Eval Health Prof · 2015 PURPOSE: This study aimed to examine the modifiable programmatic characteristics reflected in the Commission on Accreditation in Physical Therapy Education (CAPTE) Annual Accreditation Report for all accredited programs that reported pass rates on the Nati ... Full text Link to item Cite

Can experienced physiotherapists identify which patients are likely to succeed with physical therapy treatment?

Journal Article Arch Physiother · 2015 BACKGROUND: The purpose of the study was to determine if clinician predicted prognosis is associated with patient outcomes. METHODS: The study was a secondary analysis of data that were collected in 8 physiotherapy outpatient clinics. Nine physiotherapists ... Full text Link to item Cite

100 Orthopedic Cases

Book · November 18, 2014 This is the eBook of the printed book and may not include any media, website access codes, or print supplements that may come packaged with the bound book. 100 orthopedics clinical cases address all regions of the body, helping instructors ... ... Cite

Is there preliminary value to a within- and/or between-session change for determining short-term outcomes of manual therapy on mechanical neck pain?

Journal Article Journal of Manual and Manipulative Therapy · November 1, 2014 Objectives: The primary purpose of this study was to determine whether occurrences of within- and between-session changes were significantly associated with functional outcomes, pain, and self-report of recovery in patients at discharge who were treated wi ... Full text Cite

Ohio physical therapists' accuracy in identifying abnormalities on diagnostic images with and without a clinical vignette.

Journal Article Int J Sports Phys Ther · October 2014 BACKGROUND: A strong understanding of diagnostic imaging has been advocated for physical therapists. There have been recent changes in physical therapy curricula and increased opportunities to utilize imaging during clinical practice. PURPOSE: The aim of t ... Link to item Cite

Derivation of a clinical decision guide in the diagnosis of cervical facet joint pain.

Journal Article Arch Phys Med Rehabil · September 2014 OBJECTIVE: To derive a clinical decision guide (CDG) to identify patients best suited for cervical diagnostic facet joint blocks. DESIGN: Prospective cohort study. SETTING: Pain management center. PARTICIPANTS: Consecutive patients with neck pain (N=125) r ... Full text Link to item Cite

Physical therapists' clinical knowledge of multidisciplinary low back pain treatment guidelines.

Journal Article Phys Ther · July 2014 BACKGROUND: Numerous clinical practice guidelines (CPGs) have been developed to assist clinicians in care options for low back pain (LBP). Knowledge of CPGs has been marginal across health-related professions. OBJECTIVE: The aims of this study were: (1) to ... Full text Link to item Cite

Risk factors for first time incidence sciatica: a systematic review.

Journal Article Physiother Res Int · June 2014 BACKGROUND AND PURPOSE: Characteristically, sciatica involves radiating leg pain that follows a dermatomal pattern along the distribution of the sciatic nerve. To our knowledge, there are no studies that have investigated risk factors associated with first ... Full text Link to item Cite

Authors’ comments in response.

Journal Article Pain Pract · June 2014 Link to item Cite

Clinical identifiers for detecting underlying closed cervical fractures.

Journal Article Pain Pract · February 2014 BACKGROUND: Although uncommon, closed cervical fractures (CCFs) may present in orthopedic clinical settings despite previous workup. The objective of this study was to describe the characteristics associated with missed CCF. METHODS: The study was a retros ... Full text Link to item Cite

The addition of cervical unilateral posterior-anterior mobilisation in the treatment of patients with shoulder impingement syndrome: a randomised clinical trial.

Journal Article Man Ther · February 2014 Shoulder impingement syndrome (SIS) is a complex, multi-factorial problem that is treated with a variety of different conservative options. One conservative option that has shown effectiveness is manual therapy to the thoracic spine. Another option, manual ... Full text Link to item Cite

No differences in outcomes in people with low back pain who met the clinical prediction rule for lumbar spine manipulation when a pragmatic non-thrust manipulation was used as the comparator

Journal Article Physiotherapy Canada · January 1, 2014 Purpose: To investigate differences in pain and disability between patients treated with thrust manipulation (TM) and those treated with non-thrust manipulation (NTM) in a group of patients with mechanical low back pain (LBP) who had a within-session respo ... Full text Cite

The creation of the diagnostic accuracy quality scale (DAQS)

Journal Article Journal of Manual and Manipulative Therapy · January 1, 2014 Background: The utility of a dedicated clinical test is dependent on the diagnostic accuracy values and the quality of the study in which the test was examined. Scales allow a summative scoring of bias within a study. At present, there are no scales advoca ... Full text Cite

Do the reported estimates of minimal clinically important difference scores amongst hiprelated patient-reported outcome measures support their use?

Journal Article Physical Therapy Reviews · January 1, 2014 Background: The use of minimal clinically important difference (MCID) scores has become increasingly popular amongst clinicians when determining patient response to treatment. Recent evidence has suggested that MCID scores are context specific and a single ... Full text Cite

Potential caveats in the use of interpretability of outcome measures

Journal Article Physical Therapy Reviews · January 1, 2014 Patient-reported outcome measures (PROMs) are health assessment instruments that are designed to assess the health status of an individual from the patient’s perspective. However, the interpretation of these instruments is frequently misunderstood. In this ... Full text Cite

How is recovery from lower-limb conditions measured? A systematic review: OPO3130

Journal Article Journal of Orthopaedic and Sports Physical Therapy · January 2014 Cite

Association of Goutallier classification findings and presence of fat content in the multifidus muscles with delayed or poor recovery after physiotherapy in adolescents with spondylolysis

Journal Article Physiotherapy Practice and Research · December 1, 2013 Background: The purpose of the study is to measure the relationship of findings of the Goutallier classification, a qualitative measure of fat content within a designated muscle group, and a dichotomous measure of fatty infiltration (presence or not presen ... Full text Cite

Identification of cut-points in commonly used hip osteoarthritis-related outcome measures that define the patient acceptable symptom state (PASS).

Journal Article Rheumatol Int · November 2013 To determine patient acceptable symptom state (PASS) estimates in outcome measures commonly used in hip osteoarthritis (OA). Identification of cut-points on commonly used outcome measures associated with patient satisfaction with their current state of hea ... Full text Link to item Cite

Diagnostic accuracy of clinical tests of the hip: a systematic review with meta-analysis.

Journal Article Br J Sports Med · September 2013 BACKGROUND: Hip Physical Examination (HPE) tests have long been used to diagnose a myriad of intra-and extra-articular pathologies of the hip joint. Useful clinical utility is necessary to support diagnostic imaging and subsequent surgical decision making. ... Full text Link to item Cite

Criterion validation of the rate of recovery, single alphanumeric measure, in patients with low back pain.

Journal Article Physiother Res Int · June 2013 BACKGROUND AND PURPOSE: The aim of this study was to determine the criterion validity of patient rate of recovery with the Oswestry Disability Index (ODI) and the Numeric Pain Rating Scale (NPRS). METHODS: Associations between rate of recovery and ODI and ... Full text Link to item Cite

Early use of thrust manipulation versus non-thrust manipulation: a randomized clinical trial.

Journal Article Man Ther · June 2013 The purpose of this study was to investigate the comparative effectiveness of early use of thrust (TM) and non-thrust manipulation (NTM) in sample of patients with mechanical low back pain (LBP). The randomized controlled trial included patients with mecha ... Full text Link to item Cite

The role of patients' expectation of appropriate initial manual therapy treatment in outcomes for patients with low back pain.

Journal Article J Manipulative Physiol Ther · June 2013 OBJECTIVES: The purpose of this study was to compare the outcomes of patients with low back pain who had a matched, unmatched, or were indifferent with their pretreatment expectation/preference to the manual therapy thrust or nonthrust intervention. A seco ... Full text Link to item Cite

Thrust and nonthrust manipulation for older adults with low back pain: an evaluation of pain and disability.

Journal Article J Manipulative Physiol Ther · June 2013 OBJECTIVE: The purpose of the study was to compare the effects of thrust manipulation (TM) and non-TM (NTM) on a sample of older subjects with low back pain. METHODS: This is a secondary data analysis of a randomized control trial. Forty-nine subjects aged ... Full text Link to item Cite

Diagnostic accuracy of clinical tests for the detection of splenomegaly

Journal Article Physical Therapy Reviews · June 1, 2013 Background: Due to common pain referral patterns, splenomegaly may present similarly to other conditions commonly seen in the physical therapy setting, and may become deadly if undetected. Therefore, when considering a differential diagnosis for left upper ... Full text Cite

Different minimally important clinical difference (MCID) scores lead to different clinical prediction rules for the Oswestry disability index for the same sample of patients

Journal Article Journal of Manual and Manipulative Therapy · May 28, 2013 Background: Minimal clinically important difference (MCID) scores for outcome measures are frequently used evidence-based guides to gage meaningful changes. There are numerous outcome instruments used for analyzing pain, disability, and dysfunction of the ... Full text Cite

Comments

Journal Article Neurosurgery · January 1, 2013 Full text Cite

Improving tinnitus with mechanical treatment of the cervical spine and jaw.

Journal Article J Am Acad Audiol · 2013 BACKGROUND: Tinnitus affects approximately 30-50 million Americans. In approximately 0.5-1.0% of the population, tinnitus has a moderate to severe impact on their quality of life. Musculature and joint pathologies of the head and neck are frequently associ ... Full text Link to item Cite

Validity of noncontrast magnetic resonance imaging in diagnosing superior labrum anterior-posterior tears.

Journal Article J Shoulder Elbow Surg · January 2013 BACKGROUND: The biceps labral complex has received much interest in recent years as a source of shoulder pain. Magnetic resonance imaging (MRI) is the imaging modality of choice for those patients with a suspected superior labrum anterior-posterior (SLAP) ... Full text Link to item Cite

Orthopedic Physical Examination Tests An Evidence-based Approach

Book · 2013 This is the field's most comprehensive evidence-based guide to clinical tests for orthopedic physical examination.ORTHOPEDIC PHYSICAL EXAMINATION TESTS: AN EVIDENCE-BASED APPROACH, 2/e presents complete explanations and photography ... ... Cite

Which prognostic factors for low back pain are generic predictors of outcome across a range of recovery domains?

Journal Article Phys Ther · January 2013 BACKGROUND: Recovery from low back pain (LBP) is multidimensional and requires the use of multiple-response (outcome) measures to fully reflect these many dimensions. Predictive prognostic variables that are present or stable in all or most predictive mode ... Full text Link to item Cite

Clinical trial registration in physiotherapy journals: recommendations from the International Society of Physiotherapy Journal Editors.

Journal Article J Orthop Sports Phys Ther · December 2012 Clinical trial registration involves placing the protocol for a clinical trial on a free, publicly available, and electronically searchable register. Registration is considered to be prospective if the protocol is registered before the trial commences (ie, ... Full text Link to item Cite

Does the use of a prescriptive clinical prediction rule increase the likelihood of applying inappropriate treatments? A survey using clinical vignettes.

Journal Article Man Ther · December 2012 Clinical prediction rules (CPR) have been promoted as a natural progression in treatment decision-making. Methodological limitations of derivation and validation studies have resulted in some researchers questioning the indiscriminate use of CPRs. The purp ... Full text Link to item Cite

Clinimetrics corner: The global rating of change score (GRoC) poorly correlates with functional measures and is not temporally stable

Journal Article Journal of Manual and Manipulative Therapy · November 27, 2012 The Global Rating of Change Score (GRoC) is a frequently used outcome measure that is used independently to measure improvements in a patient's condition or as an anchor for other outcomes measures. The tool has been criticized for recall bias, biases in a ... Full text Cite

Physical therapists drive thrust-manipulation research

Journal Article Journal of Manual and Manipulative Therapy · November 27, 2012 Full text Cite

Effect of resistance exercises on function in older adults with osteoporosis or osteopenia: A systematic review

Journal Article Physiotherapy Canada · November 6, 2012 Purpose: To examine the effect of resistance exercises on self-reported physical function and activities of daily living (ADL) in older adults with osteoporosis or osteopenia. Methods: A search of available literature was conducted using PubMed, CINAHL, SP ... Full text Cite

Which physical examination tests provide clinicians with the most value when examining the shoulder? Update of a systematic review with meta-analysis of individual tests.

Journal Article Br J Sports Med · November 2012 OBJECTIVE: To update our previously published systematic review and meta-analysis by subjecting the literature on shoulder physical examination (ShPE) to careful analysis in order to determine each tests clinical utility. METHODS: This review is an update ... Full text Link to item Cite

An interactive rehabilitation measures database for clinicians

Journal Article Journal of Physiotherapy · September 1, 2012 Full text Cite

Quadriceps tendon rupture: a biomechanical comparison of transosseous equivalent double-row suture anchor versus transosseous tunnel repair.

Journal Article J Knee Surg · September 2012 Quadriceps rupture off the patella is traditionally repaired by a transosseous tunnel technique, although a single-row suture anchor repair has recently been described. This study biomechanically tested a new transosseous equivalent (TE) double-row suture ... Full text Link to item Cite

Can a within/between-session change in pain during reassessment predict outcome using a manual therapy intervention in patients with mechanical low back pain?

Journal Article Man Ther · August 2012 The purposes of the study were to determine whether the combined occurrence of within/between-session changes were significantly associated with functional outcomes, pain, and self-report of recovery in patients at discharge who were treated with manual th ... Full text Link to item Cite

Investigation of nonmechanical findings during spinal movement screening for identifying and/or ruling out metastatic cancer.

Journal Article Pain Pract · July 2012 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To investigate the diagnostic accuracy of lumbar movement restrictions and pain in patients with metastatic bone cancer. BACKGROUND: When evaluating patients with low back pain, physical therapists have ... Full text Link to item Cite

In response to: Cook c. how about a little love for non-thrust manipulation?

Journal Article Journal of Manual and Manipulative Therapy · June 11, 2012 Full text Cite

Publication fraud, dishonesty, and deceit

Journal Article Journal of Manual and Manipulative Therapy · June 11, 2012 Full text Cite

Best tests/clinical findings for screening and diagnosis of patellofemoral pain syndrome: a systematic review.

Journal Article Physiotherapy · June 2012 BACKGROUND: Diagnosis of patellofemoral pain syndrome (PFPS) is commonly performed using a myriad of clinical and imaging-based criteria. OBJECTIVES: The objective of this systematic literature review was to summarize the research on accuracy of individual ... Full text Link to item Cite

Arthroscopic suture bridge transosseus equivalent fixation of rotator cuff tendon preserves intratendinous blood flow at the time of initial fixation.

Journal Article J Shoulder Elbow Surg · April 2012 BACKGROUND: Current etiologic theories concerning healing rates in rotator cuff repair have focused on the blood supply in the tendinous portion of the cuff. We currently have little information regarding the effect of our repair techniques on this critica ... Full text Link to item Cite

Challenges with diagnoses: Sketchy reference standards

Journal Article Journal of Manual and Manipulative Therapy · April 1, 2012 Full text Cite

Synthesis and antihormonal properties of novel 11β-benzoxazole- substituted steroids

Journal Article Bioorganic and Medicinal Chemistry Letters · February 15, 2012 Early studies led to the identification of 11β-aryl-4×,5 times;-dihydrospiro[estra-4,9-diene-17β,4 times;-oxazole] analogs with potent and more selective antiprogestational activity compared to antiglucocorticoid activity than mifepristone. In the present ... Full text Cite

How about a little love for non-thrust manipulation?

Journal Article Journal of Manual and Manipulative Therapy · February 13, 2012 Full text Cite

The short physical performance battery as a predictor for long term disability or institutionalization in the community dwelling population aged 65 years old or older

Journal Article Physical Therapy Reviews · February 1, 2012 Background: The short physical performance battery (SPPB) is a physical performance measure that has been used to predict long term disability and/or future institutionalization in adults aged 65 years old or older. The test involves three dedicated physic ... Full text Cite

Intermediate to long-term outcomes of the STAR Total Ankle Replacement: the patient perspective.

Journal Article J Bone Joint Surg Am · January 4, 2012 BACKGROUND: The purpose of the present study was to document the patient self-reported improvements in quality of life, function, and overall impairment scores, as well as the improvement in the clinically derived outcome scores, following a Scandinavian T ... Full text Link to item Cite

Diagnostic accuracy of five orthopedic clinical tests for diagnosis of superior labrum anterior posterior (SLAP) lesions.

Journal Article J Shoulder Elbow Surg · January 2012 BACKGROUND: The clinical diagnosis of a superior labral anterior posterior (SLAP) tear is extremely challenging. Most studies that advocate selected tests have errors in study design or significant bias, or both. The purpose of this study was to identify t ... Full text Link to item Cite

The pain provocation-based straight leg raise test for diagnosis of lumbar disc herniation, lumbar radiculopathy, and/or sciatica: a systematic review of clinical utility.

Journal Article J Back Musculoskelet Rehabil · 2012 PURPOSE: The purpose of this study was to investigate the diagnostic accuracy of a finding of pain during the straight leg raise test for lumbar disc herniation, lumbar radiculopathy, and/or sciatica. PATIENTS AND METHODS: The systematic review followed th ... Full text Link to item Cite

Diagnostic Utility of Special Tests for the Elbow and Forearm

Chapter · 2012 This is the field's most comprehensive evidence-based guide to clinical tests for orthopedic physical examination.ORTHOPEDIC PHYSICAL EXAMINATION TESTS: AN EVIDENCE-BASED APPROACH, 2/e presents complete explanations and photography ... ... Cite

Diagnostic Utility of Special Tests for the Wrist and Hand

Chapter · 2012 This is the field's most comprehensive evidence-based guide to clinical tests for orthopedic physical examination.ORTHOPEDIC PHYSICAL EXAMINATION TESTS: AN EVIDENCE-BASED APPROACH, 2/e presents complete explanations and photography ... ... Cite

Role of diabetes type in perioperative outcomes after hip and knee arthroplasty in the United States.

Journal Article J Surg Orthop Adv · 2012 The objective of this study was to determine whether the type of diabetes mellitus (DM) affected the incidence of immediate perioperative complications following joint replacement. From 1988 to 2003, the Nationwide Inpatient Sample recognized 65,769 patien ... Full text Link to item Cite

Cervical myelopathy and radiculopathy

Journal Article · December 1, 2011 Full text Cite

Accuracy of glenohumeral joint injections: comparing approach and experience of provider.

Journal Article J Shoulder Elbow Surg · October 2011 BACKGROUND: The purpose of this study was to prospectively evaluate the accuracy of three different approaches used for glenohumeral injections. In addition, the accuracy of the injection was compared to the experience and confidence of the provider. METHO ... Full text Link to item Cite

Clinical tests for screening and diagnosis of cervical spine myelopathy: a systematic review.

Journal Article J Manipulative Physiol Ther · October 2011 OBJECTIVE: The purpose of this review was to investigate the diagnostic accuracy for screening and confirmation of clinical tests for cervical spine myelopathy (CSM) and to investigate the quality of the studies that have investigated these values. METHODS ... Full text Link to item Cite

The clinical value of a cluster of patient history and observational findings as a diagnostic support tool for lumbar spine stenosis.

Journal Article Physiother Res Int · September 2011 OBJECTIVE: The study aims to create a diagnostic support tool to indicate the likelihood of the presence of lumbar spinal stenosis (LSS) using a cluster of elements from the patient history and observational findings. DESIGN: The study is case based and ca ... Full text Open Access Link to item Cite

Grassroots clinical research using crowdsourcing

Journal Article Journal of Manual and Manipulative Therapy · July 28, 2011 Full text Cite

Diagnostic accuracy of clinical tests and signs of temporomandibular joint disorders: a systematic review of the literature.

Journal Article J Orthop Sports Phys Ther · June 2011 STUDY DESIGN: Systematic review. OBJECTIVE: To summarize the research on accuracy of individual clinical diagnostic signs and tests for the presence of temporomandibular disorder (TMD), and for the subclassifications affiliated with TMD. BACKGROUND: Diagno ... Full text Link to item Cite

A comparison of 3 methodological approaches to defining major clinically important improvement of 4 performance measures in patients with hip osteoarthritis.

Journal Article J Orthop Sports Phys Ther · May 2011 STUDY DESIGN: Prospective cohort study. OBJECTIVES: To establish the major clinically important improvement (MCII) of the timed up-and-go test (TUG), 40-meter self-paced walk test (40-m SPWT), 30-second chair stand (30 CST), and a 20-cm step test in patien ... Full text Link to item Cite

An investigation of the relationship between measures of pain intensity, pain affect, and disability, in patients with shoulder dysfunction.

Journal Article J Man Manip Ther · May 2011 OBJECTIVES: Numerous outcomes measures can be used to capture and differentiate change in different constructs comprising recovery. Consequently, patients are often burdened by completing a number of measures which involves considerable time and effort. Th ... Full text Link to item Cite

Emotional-based practice

Journal Article Journal of Manual and Manipulative Therapy · April 27, 2011 Full text Cite

The risk of risk-adjustment measures for perioperative spine infection after spinal surgery.

Journal Article Spine (Phila Pa 1976) · April 20, 2011 STUDY DESIGN: Cross-sectional data analysis of the Nationwide Inpatient Sample (NIS). OBJECTIVE: To develop a risk-adjustment index specific for perioperative spine infection and compare this specific index to the Deyo Comorbidity Index. Assess specific mo ... Full text Open Access Link to item Cite

Predictors of response to physical therapy intervention in patients with primary hip osteoarthritis.

Journal Article Phys Ther · April 2011 BACKGROUND: Few studies have investigated or identified common clinical tests and measures as being associated with progression of hip osteoarthritis (OA); fewer still are longitudinal studies exploring prognostic variables associated with long-term outcom ... Full text Link to item Cite

Clinical equipoise and personal equipoise: Two necessary ingredients for reducing bias in manual therapy trials

Journal Article Journal of Manual and Manipulative Therapy · March 14, 2011 Clinical and personal equipoise exists when a clinician has no good basis for a choice between two or more care options or when one is truly uncertain about the overall benefit or harm offered by the treatment to his/her patient. For most manual therapy tr ... Full text Cite

Immediate effects from manual therapy: Much ado about nothing?

Journal Article Journal of Manual and Manipulative Therapy · March 14, 2011 Full text Cite

Between-session changes predict overall perception of improvement but not functional improvement in patients with shoulder impingement syndrome seen for physical therapy: an observational study.

Journal Article Physiother Theory Pract · February 2011 Do between-session changes in global rating of change (GRoC) predict change in GRoC and self-report of function at discharge in patients with shoulder impingement that initially improve in early sessions of treatment (GRoC>5)? Is there a difference between ... Full text Link to item Cite

Diagnostic utility of clinical tests for spinal dysfunction.

Journal Article Man Ther · February 2011 The purpose of this study was to outline the clinical tests that exhibit the highest diagnostic utility for the spine. Using a sensitive search strategy but highly restrictive inclusion criteria based on assessment of quality and reduction of bias, we iden ... Full text Link to item Cite

Femoral cross-pin safety in anterior cruciate ligament reconstruction as a function of femoral tunnel position and insertion angle.

Journal Article Arthroscopy · January 2011 PURPOSE: To compare femoral cross-pin guidewire insertion at differing angles to identify "safe zones" relative to saphenous nerve, popliteus tendon, fibular collateral ligament, peroneal nerve, and femoral artery/vein locations between transtibial and med ... Full text Link to item Cite

Differences in comorbidities on low back pain and low back related leg pain.

Journal Article Pain Pract · 2011 OBJECTIVE: Investigate the influence of external factors such as depression and BMI among subjects with primary severe low back pain (LBP) and low back related leg pain (LBLP). BACKGROUND: The report of disability in patients with LBP may be significantly ... Full text Open Access Link to item Cite

A comparison of perioperative outcomes in patients with and without rheumatoid arthritis after receiving a total shoulder replacement arthroplasty.

Journal Article J Shoulder Elbow Surg · January 2011 HYPOTHESIS: The long-term survival rate of total shoulder arthroplasty (TSA) is comparable to hip and knee arthroplasty. Although TSA is considered a safe and effective procedure with low complications in patients with osteoarthritis and rheumatoid arthrit ... Full text Link to item Cite

Factor structure and concurrent/convergent validity of the modified somatic perception questionnaire and pain beliefs instrument.

Journal Article J Manipulative Physiol Ther · January 2011 OBJECTIVE: Our goal was to create a parsimonious combination of the Modified Somatic Perception Questionnaire (MSPQ) and the Pain Beliefs Screening Instrument (PBSI) through factorial structural analysis and to investigate the associations of the new scale ... Full text Link to item Cite

Orthopedic Manual Therapy An Evidence-based Approach

Book · December 27, 2010 This edition's improvements include: new chapters on neurodynamics and soft tissue mobilization; more patient cases; greater focus on clinical decision-making; and new video procedures at www.myhealthprofessionskit.com. ... Cite

Clustered clinical findings for diagnosis of cervical spine myelopathy.

Journal Article J Man Manip Ther · December 2010 Cervical spine myelopathy (CSM) is a clinical diagnosis made with imaging confirmation. At present, most clinical tests used to identify CSM are specific and no clusters of tests have proven more beneficial than stand alone tests in guiding treatment decis ... Full text Open Access Link to item Cite

Dimensionality of measures for severe unilateral ankle arthritis.

Journal Article PM R · November 2010 OBJECTIVE: To analyze the dimensionality of 2 self-report outcome measures (Foot/Ankle Disability Index [FADI] and Short-Form [SF]-36), 3 biomechanical measures (stance and step symmetry measures, gait speed, and step width), 2 physical-performance measure ... Full text Link to item Cite

Relationship between the Western Ontario and McMaster Universities Osteoarthritis Index Physical Function Subscale and physical performance measures in patients with hip osteoarthritis.

Journal Article Arch Phys Med Rehabil · October 2010 OBJECTIVE: To examine the convergent and factor validity of the Western Ontario and McMaster Universities Osteoarthritis Index physical function subscale (WOMAC-PF) using a battery of physical performance measures (PPMs) in patients with non-end-stage hip ... Full text Link to item Cite

The inter-rater reliability and diagnostic accuracy of patellar mobility tests in patients with anterior knee pain.

Journal Article Phys Sportsmed · October 2010 BACKGROUND: Patients with patellofemoral pain syndrome (PFPS) often have nonspecific findings on clinical examination. A tight knee and diminished patellar mobility in particular, may contribute to anterior knee pain. METHODS: Qualifying patients with ante ... Full text Link to item Cite

Case Report: Return to Division 1A Football Following a 1st Metatarsophalangeal Joint Dorsal Dislocation

Journal Article North American Journal of Sports Physical Therapy · September 2010 Cite

Five per cent of the time it works 100 per cent of the time: The erroneousness of the P value

Journal Article Journal of Manual and Manipulative Therapy · September 1, 2010 Full text Cite

The ability of a sustained within-session finding of pain reduction during traction to dictate improved outcomes from a manual therapy approach on patients with osteoarthritis of the hip

Journal Article Journal of Manual and Manipulative Therapy · September 1, 2010 Objectives: The objectives of this study were to: (1) determine the association of a within-session finding after traction of the hip with self-report of well-being, pain, and self-report of function at 9 weeks; and (2) to determine if the interactions bet ... Full text Cite

Vascularity and tendon pathology in the rotator cuff: a review of literature and implications for rehabilitation and surgery.

Journal Article Br J Sports Med · September 2010 OBJECTIVE: To compile histological and imaging research detailing the microvascularity of the rotator cuff and determine the clinical application of these findings for clinicians. METHODS: A computer-assisted literature search of MEDLINE (1966 to September ... Full text Link to item Cite

Measures of arch height and their relationship to pain and dysfunction in people with lower limb impairments.

Journal Article Physiother Res Int · September 2010 BACKGROUND AND PURPOSE: Debate surrounds the theory that foot structure, and more specifically, the attitude of the midfoot as typified by the longitudinal arch, is associated with complaints of pain and injuries of the lower extremity. Recently, two simpl ... Full text Link to item Cite

Positive outcomes with intra-articular glenohumeral injections are independent of accuracy.

Journal Article J Shoulder Elbow Surg · September 2010 BACKGROUND: Shoulder pain is a common, costly, and recalcitrant affliction. One treatment for shoulder pain is intra-articular injection of corticosteroid. Clinical opinion is that injection guided by palpation is accurate and effective, and there is some ... Full text Link to item Cite

Author response

Journal Article Physical Therapy · July 1, 2010 Full text Cite

Mode of administration bias.

Journal Article J Man Manip Ther · June 2010 Full text Link to item Cite

Spondyloarthritis in a patient with unilateral buttock pain and history of Crohn disease.

Journal Article Phys Ther · May 2010 BACKGROUND AND PURPOSE: Patients with inflammatory spinal conditions related to spondyloarthritis are rarely seen by primary care practitioners. However, patients with a history of inflammatory bowel disease and chronic low back or buttock pain should be e ... Full text Link to item Cite

[Regional anesthesia practice in Chile: an online survey].

Journal Article Rev Esp Anestesiol Reanim · April 2010 OBJECTIVE: To conduct a survey to profile the practice of regional anesthesia in Chile and determine the limitations on its use. MATERIAL AND METHODS: A link to an online questionnaire was sent by e-mail to anesthesiologists who were members of their natio ... Full text Link to item Cite

Costs by industry and diagnosis among musculoskeletal claims in a state workers compensation system: 1999-2004.

Journal Article Am J Ind Med · March 2010 BACKGROUND: Musculoskeletal disorders (MSDs) are a tremendous burden on industry in the United States. However, there is limited understanding of the unique issues relating to specific industry sectors, specifically the frequency and costs of different MSD ... Full text Link to item Cite

Postoperative morbidity and mortality following total knee arthroplasty with computer navigation.

Journal Article Knee · March 2010 The incidence of postoperative complications following computer navigated total knee arthroplasty is unknown. There is no published evidence to support decreased morbidity compared to standard conventional technique. The Nationwide Inpatient Sample databas ... Full text Link to item Cite

The development of a clinical decision making algorithm for detection of osteoporotic vertebral compression fracture or wedge deformity.

Journal Article J Man Manip Ther · March 2010 The clinical diagnosis of an osteoporotic vertebral compression fracture (OVCF) is challenging and requires detailed assessment using comprehensive imaging methods. Further complicating matter is that the clinical sequelae associated with OVCF typically in ... Full text Link to item Cite

Changes in transversus abdominis thickness with use of the abdominal drawing-in maneuver during a functional task.

Journal Article PM R · March 2010 OBJECTIVE: The purpose of this study was to examine an individual's ability to produce an increase in transversus abdominis (TrA) thickness during the performance of a functional task with the use of the abdominal drawing-in maneuver (ADIM). DESIGN: Within ... Full text Link to item Cite

The temporal effects of a single session of high-velocity, low-amplitude thrust manipulation on subjects with spinal pain

Journal Article Physical Therapy Reviews · February 1, 2010 Background: A high velocity, low amplitude thrust manipulation (HVLAT) is an intervention commonly used in the treatment of patients with spinal pain. Recent studies have reported on the possible neurophysiological effects of this technique which may be pe ... Full text Cite

Diagnostic accuracy and association to disability of clinical test findings associated with patellofemoral pain syndrome.

Journal Article Physiother Can · 2010 PURPOSE: To investigate the diagnostic accuracy and association to disability of selected functional findings or physical examination tests for patellofemoral pain syndrome (PFPS) in patients with anterior knee pain. METHODS: A sample of 76 consecutive pat ... Full text Link to item Cite

Activity scale for arthroplasty patients after total hip arthroplasty.

Journal Article J Arthroplasty · January 2010 The purpose of the Activity Scale for Arthroplasty Patients (ASAP) is to develop and validate a self-report questionnaire that demonstrated discrimination of functional gains, low burden, appropriate concurrent validity, and was not limited by ceiling effe ... Full text Link to item Cite

Development of a Quality Checklist Using Delphi Methods for Prescriptive Clinical Prediction Rules: the QUADCPR.

Journal Article J Manipulative Physiol Ther · January 2010 OBJECTIVE: Clinical prediction rules (CPRs) are clinician decision-making aids designed to improve the accuracy of a variety of decisions made during patient care. To our knowledge, there are no formally developed consensus-based guidelines designed to pro ... Full text Link to item Cite

17beta-Nitro-5alpha-androstan-3alpha-ol and its 3beta-methyl derivative: neurosteroid analogs with potent anticonvulsant and anxiolytic activities.

Journal Article Eur J Pharmacol · September 1, 2009 Many 17-substituted androstan-3alpha-ol analogs act as positive allosteric modulators of GABA(A) receptors and exert anticonvulsant and anxiolytic-like activity actions in animal models. The endogenous neurosteroid allopregnanolone (17beta-acetyl; 1) is am ... Full text Link to item Cite

Posterior capsular injections of ropivacaine during total knee arthroplasty: a randomized, double-blind, placebo-controlled study.

Journal Article J Arthroplasty · September 2009 We investigated the hypothesis that a posterior capsular injection of ropivacaine would improve pain and accelerate functional recovery after total knee arthroplasty in a randomized, double-blind, placebo-controlled study design. Sixty-six patients receive ... Full text Link to item Cite

Impact of body habitus on perioperative morbidity associated with fusion of the thoracolumbar and lumbar spine.

Journal Article Neurosurgery · September 2009 OBJECTIVE: Spinal fusion is performed in patients ranging from young and healthy to aged and frail. Although recent population trends in the United States are toward obesity, no large-scale study has evaluated how body habitus affects mortality, complicati ... Full text Link to item Cite

Resident duty-hour reform associated with increased morbidity following hip fracture.

Journal Article J Bone Joint Surg Am · September 2009 BACKGROUND: The Accreditation Council for Graduate Medical Education implemented resident duty-hour reform for orthopaedic resident surgeons in the United States on July 1, 2003. This study sought to determine whether the change in duty-hour regulations wa ... Full text Link to item Cite

Variables associated with the progression of hip osteoarthritis: a systematic review.

Journal Article Arthritis Rheum · July 15, 2009 OBJECTIVE: As populations age and the prevalence of hip osteoarthritis (OA) increases, health care providers must manage increasing demands for services. Evidence regarding the progression of hip OA can assist health care practitioners in determining expec ... Full text Link to item Cite

Complications of hysterectomy in women with von Willebrand disease.

Journal Article Haemophilia · July 2009 Case reports and small case series suggest that women with von Willebrand disease (VWD) are at a very high risk of bleeding complications with hysterectomy. As the procedure may be beneficial to women who suffer from heavy menstrual bleeding and have compl ... Full text Link to item Cite

The impact of glycemic control and diabetes mellitus on perioperative outcomes after total joint arthroplasty.

Journal Article J Bone Joint Surg Am · July 2009 BACKGROUND: As the prevalence of diabetes mellitus in people over the age of sixty years is expected to increase, the number of diabetic patients who undergo total hip and knee arthroplasty should be expected to increase accordingly. In general, patients w ... Full text Link to item Cite

The financial impact of orthopaedic fellowship training.

Journal Article J Bone Joint Surg Am · July 2009 BACKGROUND: Previous reports have compared the expected financial return of a medical education with those expected in other professions. However, we know of no published report estimating the financial return of orthopaedic training. The purpose of this s ... Full text Link to item Cite

Reliability and diagnostic accuracy of clinical special tests for myelopathy in patients seen for cervical dysfunction.

Journal Article J Orthop Sports Phys Ther · March 2009 STUDY DESIGN: Case control study. BACKGROUND: Myelopathy is a clinical diagnosis based largely on initial examination findings during a clinical screen, followed by imaging verification of cord injury or compression. At present, few studies have examined t ... Full text Link to item Cite

Effects of spinal manipulation on trunk proprioception in subjects with chronic low back pain during symptom remission.

Journal Article J Manipulative Physiol Ther · February 2009 OBJECTIVE: The purpose of this study was to examine the immediate effects of spinal manipulative therapy (SMT) on trunk proprioception in subjects with asymptomatic chronic low back pain (CLBP) and determine if those effects lasted 1 week. METHODS: This un ... Full text Link to item Cite

Is clinical gestalt good enough?

Journal Article J Man Manip Ther · 2009 Full text Link to item Cite

Publishing a scientific manuscript on manual therapy

Journal Article Journal of Manual and Manipulative Therapy · January 1, 2009 Publication in peer-reviewed journals is the way to introduce new information that has clinical implications. However, clinicians may be reluctant to embark on the publication process because of lack of confidence or uncertainty about the process. The aim ... Full text Cite

Physical Activity as a Mechanism for Treatment: A Call for an Acceptable Operational Definition

Journal Article American Journal of Lifestyle Medicine · January 1, 2009 Full text Cite

Comparison of perioperative complications in patients with and without rheumatoid arthritis who receive total elbow replacement.

Journal Article J Shoulder Elbow Surg · 2009 Total elbow replacement is a well-recognized surgical treatment for patients with advanced rheumatoid arthritis (RA) of the elbow. At present, there is minimal literature outlining the perioperative complications associated with total elbow replacement. We ... Full text Link to item Cite

Cementless porous-coated anatomic total hip arthroplasty at Duke: 18- to 24-year follow-up.

Journal Article J Surg Orthop Adv · 2009 The porous-coated anatomic (PCA) total hip was a first-generation cementless implant system introduced in 1983 for both primary and revision total hip arthroplasty. Between February 1983 and June 1989, 219 uncemented PCA total hips were implanted in 194 pa ... Link to item Cite

Impact of surgical approach on complications and resource utilization of cervical spine fusion: a nationwide perspective to the surgical treatment of diffuse cervical spondylosis.

Journal Article Spine J · 2009 BACKGROUND CONTEXT: Cervical spine fusion is performed for various indications in patient populations ranging from young and healthy to aged and frail. The choice of surgical approach is affected not only by disease pathoanatomy, but also by age, medical c ... Full text Link to item Cite

Correlation of magnetic resonance imaging findings and reported symptoms in patients with chronic cervical dysfunction.

Journal Article J Man Manip Ther · 2009 Information gathered from the patient history, physical examination, and advanced testing augments the decision-making process and is proposed to improve the probability of diagnostic and prognostic accuracy. However, these findings may provide inconsisten ... Full text Link to item Cite

The impact of diabetes on perioperative patient outcomes after total hip and total knee arthroplasty in the United States.

Journal Article J Arthroplasty · September 2008 The purpose of this study was to determine whether patients with diabetes mellitus (DM) have a higher likelihood of immediate, inpatient complications following primary and revision total hip (THA) and total knee arthroplasty (TKA) than patients without DM ... Full text Link to item Cite

Continental variations in preoperative and postoperative management of patients with anterior cruciate ligament repair.

Journal Article Eur J Phys Rehabil Med · September 2008 AIM: Surgeon decision making for non-operative anterior cruciate ligament (ACL) treatment and postoperative rehabilitation is influenced by a myriad of factors. The aim of this study was to investigate intercontinental differences in surgeon decision makin ... Link to item Cite

Two-year outcomes in primary THA in obese male veterans administration medical center patients.

Journal Article Rheumatol Int · September 2008 The objective of this study was to examine the influence of obesity on the rate of infection, dislocation, and overall complications in a group of male patients undergoing primary total hip arthroplasty (THA). The study involved a retrospective review of t ... Full text Link to item Cite

Effect of the Deyo score on outcomes and costs in shoulder arthroplasty patients.

Journal Article J Orthop Surg (Hong Kong) · August 2008 PURPOSE: To evaluate the effect of preoperative comorbidity status (defined by the Deyo index) on hospital mortality, postoperative complications, length of hospital stay, and hospital costs for shoulder arthroplasty patients. METHODS: The overall mean hos ... Full text Link to item Cite

Impact of preoperative neurological status on perioperative morbidity associated with anterior and posterior cervical fusion.

Journal Article J Neurosurg Spine · July 2008 Featured Publication OBJECT: Cervical spine fusion is performed for various indications in patient populations ranging from young and healthy to aged and frail. Whereas disease pathoanatomy dictates the surgical approach, preoperative neurological status does not necessarily i ... Full text Link to item Cite

Clinimetrics Corner: Use of Effect Sizes in Describing Data

Journal Article Journal of Manual & Manipulative Therapy · June 2008 Full text Cite

Manual therapy provided by physical therapists in a hospital-based setting: a retrospective analysis.

Journal Article J Manipulative Physiol Ther · June 2008 OBJECTIVE: The purpose of this study was to compare outcomes, complications, and hospital disposition in a cohort of patients hospitalized for low back pain who receive physical therapist (PT)-administered manual therapy (mobilization and manipulation) vs ... Full text Link to item Cite

The impact of race and insurance type on the outcome of endovascular abdominal aortic aneurysm (AAA) repair.

Journal Article J Vasc Surg · June 2008 BACKGROUND: Although mortality and complication rates for abdominal aortic aneurysm (AAA) have declined over the last 20 years, operative complication rates and perioperative mortality are still high, specifically for repair of ruptures. The goal of this s ... Full text Link to item Cite

Observer agreement of spine stenosis on magnetic resonance imaging analysis of patients with cervical spine myelopathy.

Journal Article J Manipulative Physiol Ther · May 2008 OBJECTIVES: The purpose of this study was to measure the intraobserver and interobserver reliability of magnetic resonance detection of cervical spondylotic myelopathy with and without operational guidelines. METHODS: Seven radiologists examined images fro ... Full text Link to item Cite

Diabetes and perioperative outcomes following cervical fusion in patients with myelopathy.

Journal Article Spine (Phila Pa 1976) · April 15, 2008 Featured Publication STUDY DESIGN: Database study using the Nationwide Inpatient Sample administrative data from 1988 through 2004. OBJECTIVE: To examine perioperative morbidity and mortality for patients diagnosed with myelopathy, with and without diabetes mellitus (DM) (and ... Full text Link to item Cite

Physical examination tests of the shoulder: a systematic review with meta-analysis of individual tests.

Journal Article Br J Sports Med · February 2008 Featured Publication OBJECTIVE: To compile and critique research on the diagnostic accuracy of individual orthopaedic physical examination tests in a manner that would allow clinicians to judge whether these tests are valuable to their practice. METHODS: A computer-assisted li ... Full text Link to item Cite

Importance of gender-specific role models in vascular surgery.

Journal Article Vascular · 2008 The percentage of female physicians selecting vascular surgery for residency and/or fellowship lags behind percentages in general surgery selections. A number of factors, such as mentorship, gender biases, lifestyle, and job characteristics, have been prop ... Full text Link to item Cite

Intrinsic and extrinsic factors important to manual therapy competency development: a delphi investigation.

Journal Article J Man Manip Ther · 2008 A learner's development of orthopaedic manual physical therapy (OMPT) psychomotor skills may be influenced by selected intrinsic and extrinsic factors. The purposes of this study were to identify the factors that influence learners' development of manual p ... Full text Link to item Cite

Excellence is a Moving Target.

Journal Article J Man Manip Ther · 2008 Full text Link to item Cite

Three-dimensional movements of the sacroiliac joint: a systematic review of the literature and assessment of clinical utility.

Journal Article J Man Manip Ther · 2008 The high frequency of static and dynamic palpation methods used during evaluation of SIJ problems in clinical practice demands an understanding of the factual quantity of movement at the SIJ. The objective of this systematic literature review was to synthe ... Full text Link to item Cite

Identifying myelopathy caused by thoracic syringomyelia: a case report.

Journal Article J Man Manip Ther · 2008 Myelopathy is a form of neurological disease caused by compression of the spinal cord. Upper and lower quarter screens are commonly used in identifying myelopathy, although most of the screen components demonstrate poor or unstudied diagnostic value. The p ... Full text Link to item Cite

Relative validity of the modified American Shoulder and Elbow Surgeons (M-ASES) questionnaire using item response theory.

Journal Article Rheumatol Int · January 2008 The modified American Shoulder and Elbow Surgeon's (M-ASES) questionnaire is purported to be a non-region specific functional measure of the entire upper extremity. The purpose of this study was to determine the factor structure of the M-ASES and to determ ... Full text Link to item Cite

Use of physical therapy in patients hospitalized with a diagnosis of generalized weakness: a retrospective study.

Journal Article J Allied Health · 2008 In a retrospective analysis of data from a national database, we observed and compared the presence of complications, lengths of stay, inflation-adjusted charges, and discharge statuses of two groups of patients hospitalized with a primary diagnosis of gen ... Link to item Cite

Intra- and inter-observer reliability of MRI examination of intervertebral disc abnormalities in patients with cervical myelopathy.

Journal Article Eur J Radiol · January 2008 PURPOSE: Intervertebral cervical disc herniation (CDH) is a relatively common disorder that can coexist with degenerative changes to worsen cervicogenic myelopathy. Despite the frequent disc abnormalities found in asymptomatic populations, magnetic resonan ... Full text Link to item Cite

Clinimetrics Corner: The Minimal Clinically Important Change Score (MCID): A Necessary Pretense.

Journal Article J Man Manip Ther · 2008 Minimal clinically important differences (MCID) are patient derived scores that reflect changes in a clinical intervention that are meaningful for the patient. At present, there are a number of different methods to obtain an MCID, as there a number of diff ... Full text Link to item Cite

Reliability and validity of the International Knee Documentation Committee (IKDC) Subjective Knee Form.

Journal Article Joint Bone Spine · December 2007 BACKGROUND: Patient-oriented questionnaires are important measures of clinical outcomes in medical practice but require systematic testing of reliability and validity. The International Knee Documentation Committee (IKDC) Subjective Knee Form is a patient- ... Full text Link to item Cite

Little science, big science: strategies for research portfolio selection in academic surgery departments.

Journal Article Ann Surg · December 2007 OBJECTIVE: To evaluate National Institutes of Health (NIH) funding for academic surgery departments and to determine whether optimal portfolio strategies exist to maximize this funding. SUMMARY BACKGROUND DATA: The NIH budget is expected to be relatively s ... Full text Link to item Cite

Diabetes and early postoperative outcomes following lumbar fusion.

Journal Article Spine (Phila Pa 1976) · September 15, 2007 Featured Publication STUDY DESIGN: Retrospective cohort study using data from the Nationwide Inpatient Sample administrative data from 1988 through 2003. OBJECTIVE: To examine perioperative morbidity and mortality for patients with and without diabetes mellitus following lumba ... Full text Link to item Cite

Assessment of the importance of glenohumeral peripheral mechanics by practicing physiotherapists.

Journal Article Physiother Res Int · September 2007 BACKGROUND AND PURPOSE: Physiotherapists develop clinical reasoning theories and applied manual therapy skills through a variety of educational exposures. No studies have assessed the importance of selected theories such as the convex-concave rule, capsula ... Full text Link to item Cite

A pragmatic neurological screen for patients with suspected cord compressive myelopathy.

Journal Article Phys Ther · September 2007 Featured Publication Physical therapists commonly use screening tests to identify upper motoneuron lesions such as cord compressive myelopathy (CCM), the presence of which necessitates appropriate medical referral. Signs and symptoms of CCM include sensory and ataxic changes o ... Full text Link to item Cite

Physical examination tests for assessing a torn meniscus in the knee: a systematic review with meta-analysis.

Journal Article J Orthop Sports Phys Ther · September 2007 Featured Publication STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVES: To identify, analyze, and synthesize the literature to determine which physical examination tests, if any, accurately diagnose a torn tibial meniscus. BACKGROUND: Knee pain has a lifetime preva ... Full text Link to item Cite

Stress fractures of the second metatarsal base occur in nondancers.

Journal Article Clin Orthop Relat Res · August 2007 Stress fractures of the base of the second metatarsal are common in ballet dancers and essentially are unreported in nondancers. We presumed base of the second metatarsal stress fractures in nondancers occur in a wide variety of individuals regardless of d ... Full text Link to item Cite

Second metatarsal stress fracture in sport: comparative risk factors between proximal and non-proximal locations.

Journal Article Br J Sports Med · August 2007 BACKGROUND: Stress fractures of the second metatarsal are common injuries in athletes and military recruits. There are two distinct areas in the second metatarsal where stress fractures develop: one proximal (at the base) and the other non-proximal (distal ... Full text Link to item Cite

Coupling behavior of the thoracic spine: a systematic review of the literature.

Journal Article J Manipulative Physiol Ther · June 2007 OBJECTIVE: The knowledge of 3-dimensional spine coupling characteristics is important for treating patients with spinal pain. The purpose of this study was to examine the coupling directional pattern of the thoracic spine by systematic review. This review ... Full text Link to item Cite

Calibration of an item pool for assessing the disability associated with foot pain: an application of item response theory to the Manchester Foot Pain and Disability Index

Journal Article Physiotherapy · June 1, 2007 Objective: To analyze the relative validity of the 17-item Manchester Foot Pain and Disability Index (MFPDI) using graded response item response theory analysis (G-IRT). Design: The design of the study involved a survey instrument validation. Participants/ ... Full text Cite

Copper-catalyzed cyclization of steroidal acylaminoacetylenes: syntheses of novel 11beta-aryl-17,17- spiro[(4'H,5'-methylene)oxazol]-substituted steroids.

Journal Article Org Lett · May 10, 2007 A variety of novel 11beta-aryl-17,17-spiro[(4'H,5'-methylene)oxazol]-substituted steroids have been synthesized in moderate to good yields via copper-catalyzed cyclization of acylaminoacetylenes. The best result was obtained with a catalytic amount of CuI ... Full text Link to item Cite

Interrater reliability and diagnostic accuracy of pelvic girdle pain classification.

Journal Article J Manipulative Physiol Ther · May 2007 OBJECTIVE: The purpose of this study was to measure the reliability of a classification system for pelvic girdle pain (PGP) and diagnostic accuracy of selected examination and clinical special findings for diagnosis of PGP. METHODS: The design involved a p ... Full text Link to item Cite

Medical screening for red flags in the diagnosis and management of musculoskeletal spine pain.

Journal Article Pain Pract · March 2007 When a patient presents with pain in the different regions of the spine, the clinician executes a region-appropriate basic examination that includes appropriate historical cues and specific physical examination tests that can be used to identify red flags. ... Full text Link to item Cite

Osteoarthritis and the impact on quality of life health indicators.

Journal Article Rheumatol Int · February 2007 The purpose of this study was to compare quality of life health identifiers in patients with and without osteoarthritis (OA) while controlling for the potentially confounding variables of gender, age, race, education, and income. Data were obtained for com ... Full text Link to item Cite

Diagnostic Utility of Special Tests for the Elbow, Wrist and Hand

Chapter · 2007 This is the field's most comprehensive evidence-based guide to clinical tests for orthopedic physical examination.ORTHOPEDIC PHYSICAL EXAMINATION TESTS: AN EVIDENCE-BASED APPROACH, 2/e presents complete explanations and photography ... ... Cite

Eight critical skill sets required for manual therapy competency: a Delphi study and factor analysis of physical therapy educators of manual therapy.

Journal Article J Allied Health · 2007 Erudition of clinical "skills" used by manually trained physical therapists involves the complex domain of cognitive, affective, and psychomotor concepts. The purpose of the study was to obtain consensus among manual therapy educators regarding stand-alone ... Link to item Cite

Differential diagnosis of atypical focal peripheral neuropathy: case report.

Journal Article Physiother Theory Pract · 2007 Carpal tunnel syndrome (CTS) is the most frequent form of focal peripheral neuropathy but is commonly misdiagnosed. The aim of this case report was to describe the differential diagnosis of CTS and atypical focal peripheral neuropathy in a 34-year-old fema ... Full text Link to item Cite

Creation and Critique of Studies of Diagnostic Accuracy: Use of the STARD and QUADAS Methodological Quality Assessment Tools.

Journal Article J Man Manip Ther · 2007 Clinical special tests are a mainstay of orthopaedic diagnosis. Within the context of the evidence-based practice paradigm, data on the diagnostic accuracy of these special tests are frequently used in the decision-making process when determining the diagn ... Full text Link to item Cite

"Tot ziens en bedankt, peter".

Journal Article J Man Manip Ther · 2007 Full text Link to item Cite

Influential variables associated with outcomes in patients with cervicogenic headache.

Journal Article J Man Manip Ther · 2007 Cervicogenic headache (CGH) is a common sequela of upper cervical dysfunction with a significant impact on patients. Diagnosis and treatment have been well validated; however, few studies have described characteristics of patients that are associated with ... Full text Link to item Cite

Geographic variation in lumbar fusion for degenerative disorders: 1990 to 2000.

Journal Article Spine J · 2007 Featured Publication BACKGROUND CONTEXT: Past studies have shown that proportion of lumbar fusion surgery to all forms of lumbar surgery is variable among geographic regions. At present, no studies have investigated whether fusion outcome is associated with geographic region. ... Full text Link to item Cite

Real-time updates of meta-analyses of HIV treatments supported by a biomedical ontology.

Journal Article Account Res · 2007 Meta-analyses involve a systematic statistical explanation of available evidence and are a commonly used systematic reviewing strategy for addressing health related scientific research. Publication biases often delay reporting of meta-analyses and subseque ... Full text Link to item Cite

Diagnosis of a rare source of upper extremity symptoms in a healthy woman after weight lifting.

Journal Article J Orthop Sports Phys Ther · November 2006 STUDY DESIGN: Resident's case problem. BACKGROUND: The popularity of weight training has increased dramatically during the past 20 years. With the increase in popularity of weight training, the rate of injury has also increased dramatically. The types of i ... Full text Link to item Cite

Validation of a Spanish version of the Short Musculoskeletal Function Assessment Questionnaire (SMFA).

Journal Article J Orthop Trauma · October 2006 OBJECTIVES: The purpose of this study was to develop a linguistically appropriate, culturally adapted, and appropriately validated Spanish version of the SMFA (SMFA-Mex). DESIGN: Validation of a survey-based outcome instrument. SETTING: Busy state hospital ... Full text Link to item Cite

In response

Journal Article Journal of Orthopaedic Trauma · October 1, 2006 Full text Cite

Coupling behavior of the cervical spine: a systematic review of the literature.

Journal Article J Manipulative Physiol Ther · September 2006 OBJECTIVE: The purpose of this study was to investigate evidence of consistency of reported directional coupling patterns among selected studies and to determine its use in manual medical treatment. METHODS: The study was a systematic literature review of ... Full text Link to item Cite

Validation of the NHANES ADL scale in a sample of patients with report of cervical pain: factor analysis, item response theory analysis, and line item validity.

Journal Article Disabil Rehabil · August 15, 2006 BACKGROUND: Few functional outcomes scales have used Item Response Theory (IRT) for validation. IRT allows individual line item validations and offers substantial advantages over classic methods of scale validation or the simplest from of IRT known as Rasc ... Full text Link to item Cite

Cross-cultural adaptation and validation of the Brazilian Portuguese version of the Neck Disability Index and Neck Pain and Disability Scale.

Journal Article Spine (Phila Pa 1976) · June 15, 2006 Featured Publication STUDY DESIGN: This study's design was a cross-cultural validation of the Neck Disability Index and Neck Pain and Disability Scale. OBJECTIVES: This study's objective was to translate, culturally adapt, and validate a Brazilian Portuguese version of the Nec ... Full text Link to item Cite

Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators.

Journal Article Mol Endocrinol · June 2006 We have previously identified a family of novel androgen receptor (AR) ligands that, upon binding, enable AR to adopt structures distinct from that observed in the presence of canonical agonists. In this report, we describe the use of these compounds to es ... Full text Link to item Cite

Item analysis of the NHANES ADL instrument in a sample of patients reporting frequent severe headaches.

Journal Article Physiother Res Int · June 2006 BACKGROUND AND PURPOSE: The National Health and Nutrition Examination Surveys (NHANES) activity of daily living (ADL) instrument is a 16-item questionnaire designed to represent the internal latent construct of activities of daily living. The purpose of th ... Full text Link to item Cite

Subjective and objective descriptors of clinical lumbar spine instability: a Delphi study.

Journal Article Man Ther · February 2006 Featured Publication Accurate ability to diagnose lumbar spine clinical instability is controversial for numerous reasons, including inaccuracy and limitations in capabilities of radiographic findings, poor reliability and validity of clinical special tests, and poor correlati ... Full text Link to item Cite

Variables associated with abandoning the manual therapy approach learned in physical therapy school

Journal Article Journal of Manual and Manipulative Therapy · January 1, 2006 Numerous manual therapy backgrounds are taught during formal education and continuing education courses within the United States. Many of these approaches employ disparate philosophies for examination and treatment. The purpose of this study was to determi ... Full text Cite

Dimensionality, internal consistency, and item analysis of the National Health and Nutrition Examination Surveys activities of daily living instrument among patients with report of low back pain.

Journal Article J Manipulative Physiol Ther · 2006 OBJECTIVE: To measure selected psychometric properties of individual item responses from the National Health and Nutrition Examination Surveys (NHANES) activities of daily living (ADL) instrument among a population of patients with low back pain (LBP). MET ... Full text Link to item Cite

Validation of an item bank in a sample of community-dwelling survivors of a stroke.

Journal Article J Geriatr Phys Ther · 2006 PURPOSE: The purpose of this study was to validate an item bank of questions associated with activities of daily living (ADL), using graded item response theory (G-IRT), in a sample of community-dwelling survivors of a stroke. METHODS: The study sample con ... Full text Link to item Cite

National trends in health care utilization and racial and socioeconomic disparities in pediatric pyogenic arthritis.

Journal Article J Pediatr Orthop · 2006 PURPOSE: To determine national trends and putative racial and socioeconomic disparities in health care utilization in pediatric patients with pyogenic arthritis over a 13-year period. STUDY DESIGN: We assessed trends in length of hospital stay, hospital di ... Full text Link to item Cite

Gender, racial, and ethnic disclosure in NIH K-Award funded diabetes and obesity clinical trials.

Journal Article Account Res · 2006 In 1993, the National Institutes of Health (NIH) passed The Revitalization Act (Subtitle B) which mandated that all NIH funded clinical trials have "appropriate representation" of minority and women subjects. Our aim was to evaluate the impact of the manda ... Full text Link to item Cite

Identifiers suggestive of clinical cervical spine instability: a Delphi study of physical therapists.

Journal Article Phys Ther · September 2005 BACKGROUND AND PURPOSE: Clinical cervical spine instability (CCSI) is controversial and difficult to diagnose. Within the literature, no clinical or diagnostic tests that yield valid and reliable results have been described to differentially diagnose this ... Link to item Cite

7alpha,11beta-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties.

Journal Article Bioorg Med Chem Lett · February 15, 2005 7alpha,11beta-Dimethyl-19-nortestosterone, made by 1,6-methyl addition to 17beta-acetoxy-11beta-methylestra-4,6-dien-3-one, was a highly potent and selective androgen response modulator, with enhanced androgen receptor binding, androgenic activity and anab ... Full text Link to item Cite

Physical therapy exercise intervention based on classification using the patient response method: A systematic review of the literature

Journal Article Journal of Manual and Manipulative Therapy · January 1, 2005 It has been suggested that inclusion into a study that categorizes patients in mutually exclusive, clinometric classifications should improve the outcome of an exercise based randomized clinical trial. This review examined the evidence regarding the effect ... Full text Cite

A variables associated with occupational and physical therapy stroke rehabilitation utilization and outcomes.

Journal Article J Allied Health · 2005 Many studies have reported the benefits of a comprehensive stroke team including occupational therapy/physical therapy (OT/PT) services; however, factors associated with access to these services are less known. This study used a subsample of the Health and ... Link to item Cite

Factors associated with physiotherapists' confidence during assessment of clinical cervical and lumbar spine instability.

Journal Article Physiother Res Int · 2005 BACKGROUND AND PURPOSE: Physiotherapists commonly encounter patients with complaints of vague, indistinguishable neck and back pain, such as clinical spine instability. Since confidence is a component of expert clinical practice, we were interested in meas ... Full text Link to item Cite

Psychosocial Variables Associated with Back Pain in the Elderly: A Retrospective Analysis

Journal Article Journal of Geriatric Physical Therapy · December 2004 Full text Cite

A survey on the importance of lumbar coupling biomechanics in physiotherapy practice.

Journal Article Man Ther · August 2004 Knowledge of lumbar coupling biomechanics is foundational in many manual therapy disciplines. 3-D studies of lumbar coupling indicate that coupling direction may not be predictable. The purpose of this study was to investigate physiotherapists' perception ... Full text Link to item Cite

Ergonomic pain--part 2: differential diagnosis and management considerations.

Journal Article Pain practice : the official journal of World Institute of Pain · June 2004 Work-related musculoskeletal disorders (MSDs) can produce ergonomic pain in several different regions of the body, including the shoulder, elbow, wrist and hand, lumbar spine, knee, and ankle/foot. Each family of disorders is distinctive in presentation an ... Full text Cite

Preventing falls with interior design

Journal Article Journal of Family and Consumer Sciences · April 2004 Cite

Ergonomic pain--part 1: etiology, epidemiology, and prevention.

Journal Article Pain practice : the official journal of World Institute of Pain · March 2004 Work-related musculoskeletal disorders (MSDs) have reached a costly epidemic proportion in recent years, producing ergonomic pain as their most frequent clinical consequence. While work-related MSDs have declined in incidence, their prevalence continues. I ... Full text Cite

Preparation of monoclonal antibodies reactive to the endogenous small molecule, anandamide.

Journal Article J Immunol Methods · February 15, 2004 The development of an easy and inexpensive immunoassay to measure the limited quantities of endogenous cannabinoids found in the body would be beneficial for both cannabinoid researchers and clinicians. This report describes the hapten design and carrier m ... Full text Link to item Cite

Inter-rater reliability of coupling pattern observations of the pathological lumbar spine: A pilot study

Journal Article Journal of Manual and Manipulative Therapy · January 1, 2004 The orthopedic assessment of low back pain by some clinicians is based to some extent, on observational detection of directional lumbar coupling analysis. This assessment process is controversial, specifically in the presence of pathology. The purpose of t ... Full text Cite

Letter to the Editor

Journal Article Journal of Manual and Manipulative Therapy · January 1, 2004 Full text Cite

Rehabilitation for clinical lumbar instability in a female adolescent competitive diver with spondylolisthesis

Journal Article Journal of Manual and Manipulative Therapy · January 1, 2004 Few studies have investigated conservative lumbar stabilization approaches with adolescent athletes, specifically those with radiographic evidence of a unilateral pars interarticularis fracture. The purpose of this case study was to describe a lumbar stabi ... Full text Cite

Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion.

Journal Article Cancer Res · November 15, 2003 The androgen receptor (AR), a member of the nuclear receptor family, is a ligand-inducible transcription factor. In the prostate gland, androgens regulate the transcription of several genes that ultimately result in cell growth and differentiation. With a ... Link to item Cite

Coupling Behavior of the Lumbar Spine: A Literature Review

Journal Article Journal of Manual and Manipulative Therapy · January 1, 2003 Coupling behavior has been described as fundamental to the theory of lumbar biomechanics. Different manual therapy approaches use discrepant coupling biomechanical models. Despite these inconsistencies, coupling models have been frequently used in the mana ... Full text Cite

Lower extremity neuromuscular recovery following anterior cruciate ligament reconstruction; a 2-week case study.

Journal Article Electromyogr Clin Neurophysiol · 2003 The lower extremity neuromuscular recovery of a 31-year-old male physical therapy student during the initial 2-weeks following anterior cruciate ligament reconstruction was evaluated by measuring involved side vastus medialis (VM), gluteus maximus (GMAX) a ... Link to item Cite

The Use of an Educational Model in the Improvement of Student Reliability in Finding R1

Journal Article Journal of Manual and Manipulative Therapy · January 1, 2003 Low inter-therapist reliability determining R1 has been reported in numerous studies. A lack of a standardized teaching method for mobilizations is frequently suggested as a reason for the poor reliability. The purpose of this study was to determine if a s ... Full text Cite

Distance Learning Outcomes for Texas Tech Universityʼs Physical Therapy Program

Journal Article Journal of Physical Therapy Education · 2003 Full text Cite

The effect of a pre-perceptual educational instrument on inter-rater reliability in physical therapists

Journal Article The Internet Journal of Allied Health Sciences & Practice · 2003 Cite

The relationship between posture and balance disturbances in women with osteoporosis

Journal Article Physical and Occupational Therapy in Geriatrics · December 1, 2002 In the population diagnosed with osteoporosis, balance impairments may contribute to frailty. Consequences of osteoporosis include thoracic kyphosis caused by compression fractures. This author investigated whether postural changes could negatively impact ... Full text Cite

Vigorous Physical Activity and Fall Occurrence

Journal Article Physical and Occupational Therapy in Geriatrics · December 1, 2002 The purpose of this study was to examine whether vigorous physical activity, defined as sports, heavy housework, or a job that involves physical labor, is associated with falls, falls with a serious injury, broken hip, and fall frequency. This study uses t ... Full text Cite

Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins.

Journal Article Endocrinology · August 2002 The steroid hormones estrogen and progesterone together regulate the development and maintenance of the female reproductive system. The actions of these two hormones are mediated by their respective nuclear receptors located within overlapping cell populat ... Full text Link to item Cite

Predictive factors in poor inter-rater reliability among physical therapists

Journal Article Journal of Manual and Manipulative Therapy · January 1, 2002 Manual therapy is a widely used form of treatment among physical therapists and has been shown to be effective in the treatment of musculoskeletal disorders. In numerous studies, the reliability of clinicians performing the four grades of mobilization of m ... Full text Cite

Effect of a 17alpha-(3-hydroxypropyl)-17beta-acetyl substituent pattern on the glucocorticoid and progestin receptor binding of 11beta-arylestra-4,9-dien-3-ones.

Journal Article Org Lett · April 5, 2001 [structure: see text]. Replacing the 17alpha-acetoxy substituent in an antiprogestational 17beta-acetyl-11beta-arylestra-4,9-dien-3-one by 3-hydroxypropyl significantly diminished glucocorticoid receptor binding with little effect on progestin receptor bin ... Link to item Cite

28-day toxicology test: indenopyridine RTI 4587-056 in male Sprague-Dawley rats.

Journal Article Reprod Toxicol · 2000 The potential toxicity of RTI 4587-056, a hexahydroindenopyridine analog of SANDOZ 20-438, was examined in adult male Sprague-Dawley rats. Testicular, intestinal, and erythropoietic histology was assessed after 28 days of gavage treatment at 0, 10, and 100 ... Full text Link to item Cite

Drugs for male contraception

Journal Article Emerging Drugs · January 1, 1999 In spite of the long and successful use of drugs for contraception for women, the development of drug contraceptives for men has not yet reached fruition. Complexity of the spermatogenic process, lack of understanding of many of the factors involved, socio ... Full text Cite

Characterization of infectious aerosols in health care facilities: an aid to effective engineering controls and preventive strategies.

Journal Article Am J Infect Control · August 1998 Assessment of strategies for engineering controls for the prevention of airborne infectious disease transmission to patients and to health care and related workers requires consideration of the factors relevant to aerosol characterization. These factors in ... Full text Link to item Cite

Enhancing value of outcomes management in outpatient rehabilitation

Journal Article J Rehab Outcome Measure · 1998 Cite

Reversal of expected stereochemical outcome in the oppolzer reaction of a cyclic N-enoylsultam: Enantioselective synthesis and absolute configuration of antispermatogenic hexahydroindeno[1,2-c]pyridines

Journal Article Tetrahedron Letters · May 26, 1997 p-Tolylmagnesium bromide added with high enantioselectivity to a cyclic enoylsultam (4), but the diastereofacial selectivity (determined by X-ray crystallography of the product) was opposite that reported for acyclic enoylsultams. The reaction was used in ... Full text Cite

16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity.

Journal Article Proc Natl Acad Sci U S A · August 6, 1996 Previously, we have shown that agonists and antagonists interact with distinct, though overlapping regions within the human progesterone receptor (hPR) resulting in the formation of structurally different complexes. Thus, a link was established between the ... Full text Link to item Cite

Structure-activity studies of 2,3,4,4a,5,9b-hexahydroindeno[1,2-c]pyridines as antispermatogenic agents for male contraception.

Journal Article J Med Chem · March 3, 1995 Analogs of (4aRS,5SR,9bRS)-2-ethyl-2,3,4,4a,5,9b-hexahydro-7-meth yl-5-p- tolyl-1H-indeno[1,2-c]pyridine (Sandoz 20-438, 10a; R1 = ethyl, R2 = R3 = methyl, R4 = H) have been synthesized and tested in mice for their ability to reduce testes weight and disru ... Full text Link to item Cite

Antibody-Catalyzed Michael Reaction of Cyanide with an α,β-Unsaturated Ketone

Journal Article Journal of the American Chemical Society · January 1, 1995 Full text Cite

Comparison in humans of the potency and pharmacokinetics of intravenously injected cocaethylene and cocaine.

Journal Article Psychopharmacology (Berl) · December 1994 Cocaethylene (the ethyl ester of benzoylecgonine) is a product of the interaction between ethanol and cocaine. The results of preclinical studies and of a pilot clinical study have shown cocaethylene to produce pharmacologic effects similar to those of coc ... Full text Link to item Cite

Effects of D-ring substituents on antiprogestational (antagonist) and progestational (agonist) activity of 11 beta-aryl steroids.

Journal Article Hum Reprod · June 1994 The discovery of antiprogestational steroids by the Roussel-Uclaf group not only was a major scientific advance but also opened the way to new methods of fertility control and new therapies for such conditions as cancer. RU486, the prototype of the series, ... Full text Link to item Cite

Determination of l-alpha-acetylmethadol, l-alpha-noracetylmethadol and l-alpha-dinoracetylmethadol in plasma by gas chromatography-mass spectrometry.

Journal Article J Chromatogr B Biomed Appl · May 13, 1994 A method is described for the simultaneous determination of l-alpha-acetylmethadol (LAAM) and its N-demethylated metabolites, l-alpha-noracetylmethadol (norLAAM) and l-alpha-dinoracetylmethadol (dinorLAAM), in plasma by gas chromatography-chemical ionizati ... Full text Link to item Cite

Human disposition of intravenous, oral and sublingual [3H]buprenorphine

Conference NIDA Research Monograph Series · January 1, 1993 Cite

Pharmacokinetics of methamphetamine self-administered to human subjects by smoking S-(+)-methamphetamine hydrochloride.

Journal Article Drug Metab Dispos · 1993 S-(+)-methamphetamine hydrochloride ("ice") is abused by smoking (inhaling the vapors of the material). Male human volunteers inhaled the drug from a pipe heated at 300 degrees-305 degrees C for an average inhaled dose of 21.8 +/- 0.3 (SE) mg. The same vol ... Link to item Cite

Analytical methods validation: Bioavailability, bioequivalence and pharmacokinetic studies. Sponsored by the American Association of Pharmaceutical Chemists, U.S. Food and Drug Administration, Fédération Internationale Pharmaceutique, Health Protection Branch (Canada) and Association of Official Analytical Chemists

Conference International Journal of Pharmaceutics · April 20, 1992 This is a summary report of the conference on 'Analytical Methods Validation: Bioavailability, Bioequivalence and Pharmacokinetic Studies.' The conference was held from December 3 to 5, 1990, in the Washington, DC area and was sponsored by the American Ass ... Full text Cite

Analytical methods validation: Bioavailability, bioequivalence, and pharmacokinetic studies

Journal Article Journal of Pharmaceutical Sciences · January 1, 1992 This is a summary report of the conference on “Analytical Methods Validation: Bioavailability, Bioequivalence and Pharmacokinetic Studies.” The conference was held from December 3 to 5, 1990, in the Washington, D.C., area and was sponsored by the American ... Full text Cite

Pharmacokinetics of oral methamphetamine and effects of repeated daily dosing in humans.

Journal Article Drug Metab Dispos · 1992 The pharmacokinetics of orally administered S-(+)-methamphetamine-d3 were investigated in human male volunteers before and after a 13-day course of a slow release form of S-methamphetamine hydrochloride. A one-compartment pharmacokinetic model incorporatin ... Link to item Cite

Clinical effects of daily methamphetamine administration.

Journal Article Clin Neuropharmacol · August 1991 This study investigated alterations in the disposition and pharmacodynamics of methamphetamine HCl after daily administration. Six male paid volunteers familiar with the use of amphetamines participated. Each subject was administered 10 mg of methamphetami ... Full text Link to item Cite

Clinical effects of methamphetamine vapor inhalation.

Journal Article Life Sci · 1991 Despite the increasing popularity of crystalline methamphetamine ("ice") vapor inhalation, no investigations have reported drug plasma concentrations and effects. Under controlled laboratory conditions, six subjects were studied. Plasma concentrations of m ... Full text Link to item Cite

The application of true countercurrent chromatography in the isolation of bioactive natural products

Journal Article Journal of Natural Products · July 1, 1989 This paper describes a highly economical and efficient chromatography system based on continuous countercurrent principles. © 1989, American Chemical Society. All rights reserved. ... Full text Cite

Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking.

Journal Article Drug Metab Dispos · 1989 The disposition of radiolabeled cocaine in humans has been studied after three routes of administration: iv injection, nasal insufflation (ni, snorting), and smoke inhalation (si). Metabolism, followed by urinary excretion of metabolites, proved to be the ... Link to item Cite

Confirmation of cannabis use. II. Determination of tetrahydrocannabinol metabolites in urine and plasma by HPLC with ECD.

Journal Article J Anal Toxicol · 1989 Simultaneous determination of delta 9-tetrahydrocannabinol (THC) and its major metabolites--11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) and 11-hydroxy-delta 9-tetrahydrocannabinol (11-OH THC)--in urine and plasma by HPLC with electroch ... Full text Link to item Cite

Interaction between marihuana and ethanol: effects on psychomotor performance.

Journal Article Alcohol Clin Exp Res · April 1988 This is a report of the results of a placebo-controlled study in which the effects of the interaction between ethanol and marihuana on drug plasma concentrations, subjective ratings of intoxication, heart rate acceleration, and psychomotor performance were ... Full text Link to item Cite

Analytical high speed countercurrent chromatography

Journal Article Journal of Liquid Chromatography · January 1, 1988 The resolution of countercurrent distribution has long been demonstrated. However, the long elution time limits its analytical applications. The development of a high speed planet centrifuge has markedly improved the efficiency of the system; thus the coun ... Full text Cite

Application of countercurrent chromatography/thermospray mass spectrometry for the analysis of natural products

Journal Article Journal of Liquid Chromatography · January 1, 1988 The versatility and high resolving power of countercurrent chromatography (CCC) has been demonstrated with a newly developed analytical high speed planet centrifuge system. Interfacing countercurrent chromatography with mass spectrometry (MS) provides a ne ... Full text Cite

Dual countercurrent chromatography

Journal Article Journal of Liquid Chromatography · January 1, 1988 A modern method of performing conventional countercurrent distribution called Dual Countercurrent Chromatography is described. The system consists of a multilayer coiled column integrated with two inlet and two outlet lines for solvent phases and a sample ... Full text Cite

Pharmacokinetics of pentobarbital enantiomers as determined by enantioselective radioimmunoassay after administration of racemate to humans and rabbits.

Journal Article J Pharmacol Exp Ther · June 1987 Radioimmunoassays were developed for R- and S-pentobarbital. The optical isomers of pentobarbital were individually alkylated to N-crotonic acid analogs that were coupled to bovine serum albumin. Immunization of rabbits with the conjugates, which were enan ... Link to item Cite

MAHA: hospital liability and the volunteer.

Journal Article Mich Hosp · November 1985 Link to item Cite

preparative separation of demeton isomers with ito multi-layer coil countercurrent chromatography

Journal Article Journal of Liquid Chromatography · October 1, 1985 The active constituents of the insecticide Demeton, consisting of isomeric 0,0-diethyl (0, S)-ethylmercaptoethyl thiophos-phates, have been conveniently separated on a preparative scale with an Ito multi-layer coil countercurrent system. © 1985 by Marcel D ... Full text Cite

Paired-ion liquid chromatographic method for the analysis of a phenanthrenemethanol antimalarial in whole blood.

Journal Article J Pharm Sci · April 1985 A sensitive and specific high-performance liquid chromatographic (HPLC) assay was developed for the determination of the candidate antimalarial (+/-)-(1,3-dichloro-6-trifluoromethyl-9-phenanthryl)-3-di-(n-butyl )aminopropanol hydrochloride in whole blood. ... Full text Link to item Cite

Pyrolysis products of heroin.

Journal Article J Forensic Sci · January 1985 Heating of heroin hydrochloride or of heroin at 250 degrees C led to extensive degradation. Major components of the pyrolysate were identified as heroin, 6-acetylmorphine, N,6-diacetylnormorphine, and N-acetylnorheroin by comparison of mass spectra and 13C ... Link to item Cite

Enantioselective drug analysis

Journal Article Pharmacy International · January 1, 1985 Cite

Plasma delta-9-tetrahydrocannabinol in pregnant sheep and fetus after inhalation of smoke from a marijuana cigarette.

Journal Article Alcohol Drug Res · 1985 Seven pregnant ewes were prepared with open-ended tracheal T tubes and with catheters in maternal femoral artery and in central circulation of fetus. Several days postoperatively, at 129-132 days gestation, ewes inhaled smoke from one marijuana cigarette c ... Link to item Cite

Identification of in vitro rat metabolites of 1-phenylcyclohexene.

Journal Article Drug Metab Dispos · 1984 In vitro metabolites of 1-phenylcyclohexene produced by the 10,000g supernatant fraction from rat liver homogenates were identified by a combination of spectrometric, chromatographic, and synthetic techniques. Initial oxidation occurred in the 3-position o ... Link to item Cite

Naltrexone disposition in man after subcutaneous administration.

Journal Article Drug Metab Dispos · 1984 The metabolism, excretion, and pharmacokinetics of [15,16-3H2]naltrexone were studied in six human males after sc administration of the hydrochloride salt. Biological fluids were analyzed by a combination of high performance liquid chromatography with liqu ... Link to item Cite

Immunoassay of enantiomers: radioimmunoassay (RIA) for d- and l-hexobarbital (HB)

Journal Article Federation Proceedings · January 1, 1984 Cite

Evaluation of immunoassays for cannabinoids in urine

Journal Article Journal of Analytical Toxicology · January 1, 1984 A comparison was made of several cannabinoid urine assays. Two hundred randomly selected urine specimens were initially screened by two enzyme immunoassays (EMIT-st and EMIT-d.a.u.) and a radioimmunoassay (Abuscreen RIA). Selected specimens found positive ... Full text Cite

Phencyclidine disposition in humans after small doses of radiolabeled drug.

Journal Article Fed Proc · June 1983 Administration of small doses of radiolabeled phencyclidine hydrochloride (PCP X HCl) to normal volunteers has resulted in basic information on the disposition of PCP in humans. The drug and its metabolites were excreted mainly in the urine whether it was ... Link to item Cite

Urine pH and phencyclidine excretion.

Journal Article Clin Pharmacol Ther · November 1982 Subeffective doses (0.5 mg) of 3H-phencyclidine (PCP) were given intravenously to three healthy men under two regimens designed to alkalinize or acidify their urine (oral sodium bicarbonate or ammonium chloride). The concentrations of PCP and its metabolit ... Full text Link to item Cite

Free-base cocaine smoking.

Journal Article Clin Pharmacol Ther · October 1982 Six healthy male, paid subjects smoked 50 mg of free-base cocaine in a specially designed glass pipe under a rigidly controlled smoking protocol. The method of heating the pipe and the temperature that produced the most efficient and consistent vaporizatio ... Full text Link to item Cite

Comparison of effects of marihuana cigarettes to three different potencies.

Journal Article Clin Pharmacol Ther · May 1982 Marihuana cigarettes containing 1.32%, 1.97%, and 2.54% delta 9-tetrahydrocannabinol (THC) were smoked by six experienced marihuana users at weekly intervals in a double-blind cross-over design under laboratory conditions. Puff duration, number of puffs ta ... Full text Link to item Cite

Phencyclidine disposition after intravenous and oral doses.

Journal Article Clin Pharmacol Ther · May 1982 [3H]-Phencyclidine (PCP) hydrochloride was given in intravenous (0.1 or 1 mg) or oral (1 mg) doses to male subjects. After 1 mg IV, drug and metabolites were recovered in urine (72.8 +/- 4.0% of dose), feces (4.7 +/- 0.9%), and perspiration. Fecal excretio ... Full text Link to item Cite

Phencyclidine and phenylcyclohexene disposition after smoking phencyclidine.

Journal Article Clin Pharmacol Ther · May 1982 Five men who smoked parsley cigarettes containing 100 micrograms of [3H]-phencyclidine hydrochloride (PCP.HCl) inhaled 69 +/- 5(SEM) % of the total radioactivity in the cigarette. Both PCP and its pyrolysis product, 1-phenylcyclohexene (PC), were found and ... Full text Link to item Cite

Immunoassay of racemic drugs: a problem of enantioselective antisera and a solution.

Journal Article J Pharmacol Exp Ther · March 1982 Although it has been demonstrated that immunization with drug-protein conjugates derived from enantiomerically pure drug derivatives leads to stereoselective antisera, the effect of the use of conjugates of racemic drugs on antibody stereoselectivity has r ... Link to item Cite

Orthostatic hypotension after delta 9-tetrahydrocannabinol marihuana inhalation.

Journal Article Ophthalmic Res · 1982 3 male glaucoma subjects experienced orthostatic hypotension within 10 min after completing 2% delta 9-THC ranging from 57 to 233 ng/ml were found 5 min after smoking. Peripheral venodilation appeared responsible for the precipitous decrease in systolic bl ... Full text Link to item Cite

Radioimmunoassays for cannabinoids.

Journal Article NIDA Res Monogr · 1982 The simplicity, sensitivity, and specificity of radioimmunoassay have made it an attractive procedure for the analysis of delta-9-tetrahydrocannabinol (THC) in biological fluids or tissues. The presence of closely related compounds such as metabolites may ... Link to item Cite

Hybridoma antibodies to S-warfarin

Journal Article Federation Proceedings · January 1, 1981 Cite

Bioavailability of terfenadine in man.

Journal Article Biopharm Drug Dispos · 1981 Fourteen normal male subjects were given either 60mg or 180mg of terfenadine suspension in a randomized two-way crossover study. Peak plasma concentrations of 1.544 +/- 0.726 (mean +/- S.D.) ng ml-1 were obtained in 0.786 h following the 60 mg dose and dis ... Full text Link to item Cite

Radioimmunoassay for terfenadine in human plasma.

Journal Article J Pharm Sci · December 1980 A radioimmunoassay procedure was developed for the antihistamine terfenadine (alpha[4-(1,2-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol). The keto analog of terfenadine was converted to its O-carboxymethyloxime derivative, which was ... Full text Link to item Cite

Warfarin enantiomer disposition: determination by stereoselective radioimmunoassay.

Journal Article J Pharmacol Exp Ther · September 1979 Immunoassay techniques offer promise for the selective analysis of enantiomeric substances without prior separation. In a demonstrationof this selective analysis, radioimmunoassays were developed for R- and S-warfarin. The 4'-carboxyethyl analog of R,S-war ... Link to item Cite

Synthesis of 11 beta,13 beta- and 13 beta,16 beta-propano steroids: probes of hormonal activity.

Journal Article J Med Chem · August 1979 Syntheses of 11 beta,13 beta- and 13 beta,16 beta-propano derivatives of 17 alpha-ethynyl-17 beta-hydroxygon-4-en-3-one are described. The 13 beta,16 beta bridge was constructed by intramolecular alkylation of the C-16 enolate anion from 3-methoxy-13 beta- ... Full text Link to item Cite

Pharmacokinetic profile of caffeine in the premature newborn infant with apnea.

Journal Article J Pediatr · April 1979 The pharmacokinetic profile of caffeine was studied in 32 premature newborn infants with apnea: 12 following a single intravenous dose; 3 after a single oral dose; 7 during treatment with an initial empirical (high) maintenance dose schedule; and 10 during ... Full text Link to item Cite

Synthetic Route to an Aromatic Analog of Strigol

Journal Article Journal of Organic Chemistry · January 1, 1979 An aromatic analogue which contains all but one of the carbon atoms of the witchweed seed germination stimulant strigol has been prepared. 6-Methyldihydrocoumarin was converted to a phenolic indanone (4) which was alkylated by reaction of its dianion with ... Full text Cite

Secobarbital enantiomers: Stereoselective radioimmunoassay in human plasma and saliva

Journal Article Federation Proceedings · January 1, 1979 Cite

Synthesis of high specific activity R‐and S‐ warfarin‐3H

Journal Article Journal of Labelled Compounds and Radiopharmaceuticals · January 1, 1979 4‐Hydroxy‐3‐[3‐oxo‐1‐(3‐bromophenyl)butyl]‐2H‐1‐benzopyran‐2‐one (3′ ‐bromowarfarin) was synthesized and resolved into its enantiomers by formation of the d‐10‐camphorsulfonate diastereoisomers, which were separated by liquid chromatography and hydrolyzed. ... Full text Cite

Steady-state serum levels of quinidine and active metabolites in cardiac patients with varying degrees of renal function.

Journal Article Clin Pharmacol Ther · July 1978 The concentrations of quinidine, (3S)-3-hydroxyquinidine (3-OH), and 2'-oxoquinidinone (2'-OXO) in serum samples from 25 patients on long-term quinidine therapy were determined by a high-pressure liquid chromatography assay. Large individual variation in t ... Full text Link to item Cite

Synthesis and activity (post-coital antifertility and hormonal) of 2,7α-dimethyl steroids

Journal Article Journal of Steroid Biochemistry · January 1, 1978 Full text Cite

Caffeine in plasma and saliva by a radioimmunoassay procedure.

Journal Article J Pharmacol Exp Ther · December 1976 Caffeine was analyzed in human plasma and saliva by a simple, rapid, and sensitive radioimmunoassay procedure. Immunization of rabbits with an antigen prepared by coupling 7-(5-carboxypentyl)-1,3-dimethylxanthine to bovine serum albumin resulted in the for ... Link to item Cite

Radiommunoassay of delta9-tetrahydrocannabinol.

Journal Article NIDA Res Monogr · May 1976 Link to item Cite

Theophylline radioimmunoassay: synthesis of antigen and characterization of antiserum.

Journal Article Res Commun Chem Pathol Pharmacol · March 1976 Antisera to theophylline (T) have been obtained by immunizing rabbits with a conjugate of 8-(3-carboxypropyl)-1,3-dimethylxanthine and bovine serum albumin. Comparison of 50% displacement values indicated good selectivity for T vs. a number of other xanthi ... Link to item Cite

Measurement of diphenylhydantoin in 0.1-ml plasma samples: gas chromatography and radioimmunoassay compared.

Journal Article Clin Chem · February 1976 Concentrations of diphenylhydantoin in 364 plasma samples have been measured both by radioimmunoassay and with a recently developed gas-chromatographic method, which requires only 0.1 ml of plasma per determination. There was an excellent correlation betwe ... Link to item Cite

Active quinidine metabolites

Journal Article Clinical Research · January 1, 1976 Cite

Phenytoin and phenobarbital concentrations in saliva and plasma measured by radioimmunoassay.

Journal Article Clin Pharmacol Ther · December 1975 Saliva and plasma levels of phenytoin (DPH) and phenobarbital (PB) in a series of epileptic patients were compared by means of a radioimmunoassat (RIA) that required only 10 mul of saliva or plasma. There was an excellent linear relation (r = 0.98) between ... Full text Link to item Cite

Flavonoids. 8. Synthesis and antifertility and estrogen receptor binding activities of coumarins and delta3-isoflavenes.

Journal Article J Med Chem · October 1975 A series of coumarins and delta3-isoflavenes was prepared. Although antifertility activity was shown by all of these compounds, the required dosage in mice varied from 13.5 mug/kg/day to 50 mg/kg/day. The most potent compounds were the 2-methyl-4-ethylisof ... Full text Link to item Cite

A complex pattern of disposition of phenytoin in severe intoxication.

Journal Article Clin Pharmacol Ther · July 1975 A 5-year-old child developed phenytoin (diphenylhydantoin, DPH) toxicity after receiving 500 mg of the drug daily for 3 weeks. Plasma, urine, and duodenal fluid were collected for assay of DPH and its metabolites. The peak plasma concentration of DPH was 1 ... Full text Link to item Cite

Quinidine radioimmunoassay: development and characterization of antiserum

Journal Article Pharmacologist · January 1, 1975 Cite

Phenylbutazone antiserum

Journal Article Federation Proceedings · January 1, 1975 Cite

Norethindrone plasma levels in human subjects.

Journal Article Life Sci · November 1, 1974 Full text Link to item Cite

Specificity of barbiturate antisera

Journal Article Pharmacologist · January 1, 1974 Cite

Comparison of diphenylhydantoin and phenobarbital serum and blood levels

Journal Article Pharmacologist · January 1, 1974 Cite

Ethynodiol diacetate metabolites in human plasma.

Journal Article J Pharmacol Exp Ther · June 1973 Link to item Cite

Antiserum to diphenylhydantoin: preparation and characterization.

Journal Article Res Commun Chem Pathol Pharmacol · May 1973 Link to item Cite

Specific ria for 5,5 diphenylhydantoin

Journal Article Pharmacologist · January 1, 1973 Cite

Norethynodrel metabolites in human plasma and urine.

Journal Article J Pharmacol Exp Ther · October 1972 Link to item Cite

Metabolism of norethynodrel by rat liver.

Journal Article Biochem Pharmacol · July 1971 Full text Link to item Cite

The effect of different incubation systems on the in vitro metabolism of norethynodrel

Journal Article Journal of Steroid Biochemistry · January 1, 1971 The in vitro metabolism of norethynodrel by male rat liver has been studied under a number of different incubation conditions. Both the postmitochondrial supernatant and the microsomal pellet were used as the enzyme source. Optimum incubation conditions fo ... Full text Cite

The pectinase inhibitor from sericea (Lespedeza cuneata)

Journal Article Lloydia · December 1, 1970 A pectinase inhibitor extracted from sericea (Lespedeza cuneata Don) could be purified by countercurrent distribution in an isopropyl alcohol-water-sodium chloride system or by dialysis. Purified material was less stable than cruder preparations. Although ... Cite

DL-4-acetamido-4-hydroxy-2-butenoic acid γ-lactone

Journal Article Organic Preparations and Procedures · January 1, 1970 Full text Cite

Synthesis of (R)‐5‐(2′‐pentyl)barbituric acid derivatives of high optical purity

Journal Article Journal of Heterocyclic Chemistry · January 1, 1969 Natural (R)‐(+)‐pulegone (1) was converted to 3‐methylhexanoic acid (4) by a sequence which precluded racemization. Conversion of this to malonic esters8, 5, and 11 permitted the synthesis of pentobarbital (6) secobarbital (12), thiopental (9),thiamylal(10 ... Full text Cite

An examination of the hexane extract of flue-cured tobacco involving gel permeation chromatography

Journal Article Phytochemistry · January 1, 1969 Techniques have been investigated for separating the hexane extract of flue-cured tobacco into classes based on polarity and molecular size. The method developed, which depends upon counter-current distribution for polarity separation and gel permeation ch ... Full text Cite

A ready synthetical route to the estrogenic 2,4-dialkylisoflav-3-enes

Journal Article Chemical Communications London · December 1, 1968 Full text Cite

Cholesteryl esters in flue-cured tobacco.

Journal Article Experientia · December 15, 1967 Full text Link to item Cite

Germination of witchweed (striga lutea lour.): Isolation and properties of a potent stimulant

Journal Article Science · January 1, 1966 Abstract. A crystalline germination stimulant (trivial name strigol) for the root parasite, witchweed (Striga lutea Lour.), has been isolated from cotton root exudates and characterized as a C19H22O6 compound. Although appa ... Full text Cite

Flavonoids. I. Synthesis of 2,2-Dialkyl-Δ3-isoflavenes from Coumarins

Journal Article Journal of Organic Chemistry · December 1, 1965 The preparation of a series of 2,2-dialkyl-Δ3-isoflavenes [3-aryl-l(2H)-benzopyrans] has been carried out by reaction of Grignard reagents with coumarins. The required coumarins were synthesized by the following route: arylacetonitrile → α-aryl-β-ketonitri ... Full text Cite

Flavonoids. II. Rearrangement of 2,2-Dimethyl-Δ3-isoflavenes to Indenes

Journal Article Journal of Organic Chemistry · December 1, 1965 Attempts to demethylate methoxy derivatives of 2,2-dimethyl-Δ3-isoflavenes under acidic conditions (pyridine hydrochloride, aluminum chloride) led to facile rearrangement to the corresponding 7-hydroxyindenes. © 1965, American Chemical Society. All rights ... Full text Cite

Physical Activity Promotion Attitudes and Practices Among Outpatient Physical Therapists: Results of a National Survey.

Journal Article J Geriatr Phys Ther BACKGROUND AND PURPOSE: Physical activity (PA) promotion delivered by physical therapists is effective. However, little is known about how much PA promotion is integrated into outpatient US physical therapist practice. The purpose of this study was to dete ... Full text Link to item Cite