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Pratap Challa

Professor of Ophthalmology
Ophthalmology, Glaucoma
Box 3802 Med Ctr, Durham, NC 27710
Wadsworth Bldg, Durham, NC 27710

Selected Publications


Influence of Growth Differentiation Factor 15 on Intraocular Pressure in Mice.

Journal Article Lab Invest · April 2024 Growth differentiation factor 15 (GDF15), a stress-sensitive cytokine, and a distant member of the transforming growth factor β superfamily, has been shown to exhibit increased levels with aging, and in various age-related pathologies. Although GDF15 level ... Full text Link to item Cite

Resident involvement in cataract surgery at the Veterans Health Administration: complications, case complexity, and the role of experience.

Journal Article J Cataract Refract Surg · March 1, 2023 PURPOSE: To characterize intraoperative complications, case complexity, and changes in complication rates with surgical experience for cataract surgeries involving residents at the Veterans Health Administration (VHA). SETTING: All VHA facilities where cat ... Full text Link to item Cite

Learning From the 2021 Ophthalmology Match: Virtual Residency Matching During the COVID-19 Pandemic.

Journal Article J Grad Med Educ · December 2022 BACKGROUND: The effect of virtual interviews on residency match outcomes during the COVID-19 pandemic is unknown. Examining the ophthalmology match may help inform all specialties undergoing virtual interviews. OBJECTIVE: To determine the impact of allopat ... Full text Link to item Cite

Role of vasorin, an anti-apoptotic, anti-TGF-β and hypoxia-induced glycoprotein in the trabecular meshwork cells and glaucoma.

Journal Article J Cell Mol Med · April 2022 Glaucoma, one of the leading causes of irreversible blindness, is commonly associated with elevated intraocular pressure due to impaired aqueous humour (AH) drainage through the trabecular meshwork. The aetiological mechanisms contributing to impaired AH o ... Full text Link to item Cite

Elevated Levels of Growth/Differentiation Factor-15 in the Aqueous Humor and Serum of Glaucoma Patients.

Journal Article J Clin Med · January 29, 2022 Dysregulated levels of growth/differentiation factor-15 (GDF15), a divergent member of the transforming growth factor-beta super family, have been found to be associated with the pathology of various diseases. In this study, we evaluated the levels of GDF1 ... Full text Link to item Cite

Infections and glaucoma.

Journal Article Surv Ophthalmol · 2022 Glaucoma is an intraocular pressure-related ophthalmic disease with multiple causes that results in an optic neuropathy and vision loss. Intraocular pressure elevation is among its strongest risk factors. While glaucoma is mostly primary in etiology, secon ... Full text Link to item Cite

Long-Term Decrease of Intraocular Pressure in Rats by Viral Delivery of miR-146a.

Journal Article Transl Vis Sci Technol · July 1, 2021 PURPOSE: To evaluate the effects of miR-146a in trabecular meshwork (TM) cells and on intraocular pressure (IOP) in vivo via viral delivery of miR-146a to the anterior chamber of rat eyes. METHODS: Human TM cells were transfected with miR-146 mimic or inhi ... Full text Link to item Cite

Netarsudil Improves Trabecular Outflow Facility in Patients with Primary Open Angle Glaucoma or Ocular Hypertension: A Phase 2 Study.

Journal Article Am J Ophthalmol · June 2021 PURPOSE: Intraocular pressure (IOP) reduction is key to controlling primary open angle glaucoma (POAG). Pharmacotherapies for POAG or ocular hypertension (OHT) commonly lower IOP by increasing uveoscleral outflow or decreasing aqueous humor production. Net ... Full text Link to item Cite

Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis.

Journal Article Elife · March 30, 2021 Glucocorticoids are widely used as an ophthalmic medication. A common, sight-threatening adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the conventional outflow pathway. We report that netarsudil, a rho-kinase inhibi ... Full text Link to item Cite

Infectious and Sterile Endophthalmitis in Eyes with Glaucoma Drainage Device from Two Large Ophthalmic Institutions.

Journal Article Ophthalmol Glaucoma · 2021 PURPOSE: To describe the predisposing factors, presentation, management, and outcome of glaucoma drainage implant (GDI)-associated endophthalmitis. DESIGN: Retrospective chart review. PARTICIPANTS: Eyes that developed GDI-associated endophthalmitis between ... Full text Link to item Cite

Vasorin, an antagonist of TGF-β is decreased in glaucoma patients

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Factors Impacting Outcomes and the Time to Recovery From Malignant Glaucoma.

Journal Article Am J Ophthalmol · January 2020 PURPOSE: To identify factors associated with the successful treatment of malignant glaucoma (MG). DESIGN: Retrospective case series. METHODS: Setting: single institution; study population: 64 eyes (55 subjects) with MG; observation procedure(s): chart revi ... Full text Link to item Cite

Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity.

Journal Article Biochim Biophys Acta Mol Basis Dis · January 1, 2020 Ocular hypertension due to impaired aqueous humor (AH) drainage through the trabecular meshwork (TM) is a major risk factor for glaucoma, a leading cause of irreversible blindness. However, the etiology of ocular hypertension remains unclear. Although auto ... Full text Link to item Cite

Reply to Correspondence.

Journal Article Am J Ophthalmol · January 2020 Full text Link to item Cite

Recurrent Tube Erosions with Anti-Vascular Endothelial Growth Factor Therapy in Patients with Age-Related Macular Degeneration.

Journal Article Ophthalmol Glaucoma · 2020 PURPOSE: To determine the rates of primary and recurrent glaucoma tube shunt erosions in patients with age-related macular degeneration (AMD) receiving anti-vascular endothelial growth factor (VEGF) intravitreal injections. DESIGN: Retrospective case serie ... Full text Link to item Cite

Influence of Growth Differentiation Factor 15 on Intraocular Pressure in Mice.

Journal Article Lab Invest · April 2024 Growth differentiation factor 15 (GDF15), a stress-sensitive cytokine, and a distant member of the transforming growth factor β superfamily, has been shown to exhibit increased levels with aging, and in various age-related pathologies. Although GDF15 level ... Full text Link to item Cite

Resident involvement in cataract surgery at the Veterans Health Administration: complications, case complexity, and the role of experience.

Journal Article J Cataract Refract Surg · March 1, 2023 PURPOSE: To characterize intraoperative complications, case complexity, and changes in complication rates with surgical experience for cataract surgeries involving residents at the Veterans Health Administration (VHA). SETTING: All VHA facilities where cat ... Full text Link to item Cite

Learning From the 2021 Ophthalmology Match: Virtual Residency Matching During the COVID-19 Pandemic.

Journal Article J Grad Med Educ · December 2022 BACKGROUND: The effect of virtual interviews on residency match outcomes during the COVID-19 pandemic is unknown. Examining the ophthalmology match may help inform all specialties undergoing virtual interviews. OBJECTIVE: To determine the impact of allopat ... Full text Link to item Cite

Role of vasorin, an anti-apoptotic, anti-TGF-β and hypoxia-induced glycoprotein in the trabecular meshwork cells and glaucoma.

Journal Article J Cell Mol Med · April 2022 Glaucoma, one of the leading causes of irreversible blindness, is commonly associated with elevated intraocular pressure due to impaired aqueous humour (AH) drainage through the trabecular meshwork. The aetiological mechanisms contributing to impaired AH o ... Full text Link to item Cite

Elevated Levels of Growth/Differentiation Factor-15 in the Aqueous Humor and Serum of Glaucoma Patients.

Journal Article J Clin Med · January 29, 2022 Dysregulated levels of growth/differentiation factor-15 (GDF15), a divergent member of the transforming growth factor-beta super family, have been found to be associated with the pathology of various diseases. In this study, we evaluated the levels of GDF1 ... Full text Link to item Cite

Infections and glaucoma.

Journal Article Surv Ophthalmol · 2022 Glaucoma is an intraocular pressure-related ophthalmic disease with multiple causes that results in an optic neuropathy and vision loss. Intraocular pressure elevation is among its strongest risk factors. While glaucoma is mostly primary in etiology, secon ... Full text Link to item Cite

Long-Term Decrease of Intraocular Pressure in Rats by Viral Delivery of miR-146a.

Journal Article Transl Vis Sci Technol · July 1, 2021 PURPOSE: To evaluate the effects of miR-146a in trabecular meshwork (TM) cells and on intraocular pressure (IOP) in vivo via viral delivery of miR-146a to the anterior chamber of rat eyes. METHODS: Human TM cells were transfected with miR-146 mimic or inhi ... Full text Link to item Cite

Netarsudil Improves Trabecular Outflow Facility in Patients with Primary Open Angle Glaucoma or Ocular Hypertension: A Phase 2 Study.

Journal Article Am J Ophthalmol · June 2021 PURPOSE: Intraocular pressure (IOP) reduction is key to controlling primary open angle glaucoma (POAG). Pharmacotherapies for POAG or ocular hypertension (OHT) commonly lower IOP by increasing uveoscleral outflow or decreasing aqueous humor production. Net ... Full text Link to item Cite

Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis.

Journal Article Elife · March 30, 2021 Glucocorticoids are widely used as an ophthalmic medication. A common, sight-threatening adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the conventional outflow pathway. We report that netarsudil, a rho-kinase inhibi ... Full text Link to item Cite

Infectious and Sterile Endophthalmitis in Eyes with Glaucoma Drainage Device from Two Large Ophthalmic Institutions.

Journal Article Ophthalmol Glaucoma · 2021 PURPOSE: To describe the predisposing factors, presentation, management, and outcome of glaucoma drainage implant (GDI)-associated endophthalmitis. DESIGN: Retrospective chart review. PARTICIPANTS: Eyes that developed GDI-associated endophthalmitis between ... Full text Link to item Cite

Vasorin, an antagonist of TGF-β is decreased in glaucoma patients

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Factors Impacting Outcomes and the Time to Recovery From Malignant Glaucoma.

Journal Article Am J Ophthalmol · January 2020 PURPOSE: To identify factors associated with the successful treatment of malignant glaucoma (MG). DESIGN: Retrospective case series. METHODS: Setting: single institution; study population: 64 eyes (55 subjects) with MG; observation procedure(s): chart revi ... Full text Link to item Cite

Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity.

Journal Article Biochim Biophys Acta Mol Basis Dis · January 1, 2020 Ocular hypertension due to impaired aqueous humor (AH) drainage through the trabecular meshwork (TM) is a major risk factor for glaucoma, a leading cause of irreversible blindness. However, the etiology of ocular hypertension remains unclear. Although auto ... Full text Link to item Cite

Reply to Correspondence.

Journal Article Am J Ophthalmol · January 2020 Full text Link to item Cite

Recurrent Tube Erosions with Anti-Vascular Endothelial Growth Factor Therapy in Patients with Age-Related Macular Degeneration.

Journal Article Ophthalmol Glaucoma · 2020 PURPOSE: To determine the rates of primary and recurrent glaucoma tube shunt erosions in patients with age-related macular degeneration (AMD) receiving anti-vascular endothelial growth factor (VEGF) intravitreal injections. DESIGN: Retrospective case serie ... Full text Link to item Cite

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.

Journal Article JAMA · November 5, 2019 IMPORTANCE: Primary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations of African ancestry compared with European or Asian ancestry. Despite this, individuals of African ancestry remain understudi ... Full text Link to item Cite

Treatment Outcomes Following Resident Performed Nonvalved (Baerveldt 350) Glaucoma Drainage Device Implantation.

Journal Article J Glaucoma · November 2019 PRECIS: When compared with outcomes by glaucoma specialists in several prospective studies, residents at the Durham Veterans Affairs Medical Center achieved comparable reductions in intraocular pressure (IOP) and failure rates during the year following Bae ... Full text Link to item Cite

Generation of Reversible Immortalized Cell Lines to Model Pseudoexfoliation Syndrome

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Supervision and autonomy of ophthalmology residents in the outpatient clinic in the United States II: a survey of senior residents.

Journal Article BMC Med Educ · June 13, 2019 BACKGROUND: A balance between autonomy and supervision can be difficult to obtain in medical education. In this study, we sought to determine whether the presence and level of supervision of ophthalmology resident outpatient clinic correlates with metrics ... Full text Link to item Cite

Prophylactic anterior vitrectomy during cataract surgery in eyes at increased risk for aqueous misdirection.

Journal Article Am J Ophthalmol Case Rep · December 2018 PURPOSE: Patients with chronic narrow angle glaucoma (CNAG) are at increased risk of developing aqueous misdirection (AM) following intraocular surgery. We present a retrospective case series on the use of posterior capsulorrhexis with core vitrectomy by a ... Full text Link to item Cite

Composition of Exfoliation Material.

Journal Article J Glaucoma · July 2018 Exfoliation glaucoma (XFG) is the most common identifiable cause of open-angle glaucoma worldwide, and results from the accumulation of extracellular fibrillary material (XFM) within the trabecular meshwork and the Schlemm canal leading to increased intrao ... Full text Link to item Cite

Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma.

Journal Article Hum Mol Genet · April 1, 2018 Both exfoliation glaucoma (XFG) and primary open-angle glaucoma (POAG) have been linked to decreased conventional outflow of aqueous humor (AH). To better understand the molecular changes in the AH content under such conditions, we analyzed the miRNA profi ... Full text Link to item Cite

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.

Journal Article Nat Genet · July 2017 Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma and a major cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A, have previously been associated with XFS. To further elucidate the genetic basis of X ... Full text Link to item Cite

The influence of intraocular pressure on the severity of diabetic retinopathy

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Evaluation of the potential of iPSCs as a tool to study Pseudoexfoliation Syndrome

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

VEGF as a Paracrine Regulator of Conventional Outflow Facility.

Journal Article Invest Ophthalmol Vis Sci · March 1, 2017 PURPOSE: Vascular endothelial growth factor (VEGF) regulates microvascular endothelial permeability, and the permeability of Schlemm's canal (SC) endothelium influences conventional aqueous humor outflow. We hypothesize that VEGF signaling regulates outflo ... Full text Link to item Cite

Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration.

Journal Article Invest Ophthalmol Vis Sci · March 1, 2017 PURPOSE: We assess the effect of intravitreal anti-VEGF injections on tonographic outflow facility. METHODS: Patients with age-related macular degeneration who had received unilateral intravitreal anti-VEGF injections were recruited into two groups, those ... Full text Link to item Cite

Simultaneous Implantation of an Ahmed and Baerveldt Glaucoma Drainage Device for Uncontrolled Intraocular Pressure in Advanced Glaucoma.

Journal Article J Glaucoma · February 2017 PURPOSE: To evaluate efficacy and safety of a novel technique, simultaneous implantation of Ahmed and Baerveldt shunts, for improved control of intraocular pressure (IOP) in advanced glaucoma with visual field defects threatening central fixation. PATIENTS ... Full text Link to item Cite

Four-dimensional microscope- integrated optical coherence tomography to enhance visualization in glaucoma surgeries.

Journal Article Indian J Ophthalmol · January 2017 We report the first use of swept-source microscope-integrated optical coherence tomography (SS-MIOCT) capable of live four-dimensional (4D) (three-dimensional across time) imaging intraoperatively to directly visualize tube shunt placement and trabeculecto ... Full text Link to item Cite

Atypical Presentation of Acute Angle-Closure Glaucoma in Maroteaux-Lamy Mucopolysaccharidosis with Patent Prophylactic Laser Peripheral Iridotomy: A Case Report.

Journal Article Perm J · 2017 INTRODUCTION: Maroteaux-Lamy syndrome (MLS) is a rare progressive condition characterized by inflammation and scarring of multiple organs. Ocular complications caused by anterior segment abnormalities commonly cause visual impairment in MLS. Angle-closure ... Full text Link to item Cite

Physical Factors Affecting Outflow Facility Measurements in Mice.

Journal Article Invest Ophthalmol Vis Sci · December 2015 PURPOSE: Mice are commonly used to study conventional outflow physiology. This study examined how physical factors (hydration, temperature, and anterior chamber [AC] deepening) influence ocular perfusion measurements in mice. METHODS: Outflow facility (C) ... Full text Link to item Cite

Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus.

Journal Article Hum Mol Genet · November 15, 2015 Exfoliation syndrome (XFS) is a common, age-related, systemic fibrillinopathy. It greatly increases risk of exfoliation glaucoma (XFG), a major worldwide cause of irreversible blindness. Coding variants in the lysyl oxidase-like 1 (LOXL1) gene are strongly ... Full text Link to item Cite

A common variant near TGFBR3 is associated with primary open angle glaucoma.

Journal Article Hum Mol Genet · July 1, 2015 Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significa ... Full text Link to item Cite

Complete 360° circumferential gonioscopic optical coherence tomography imaging of the iridocorneal angle.

Journal Article Biomed Opt Express · April 1, 2015 Clinically, gonioscopy is used to provide en face views of the ocular angle. The angle has been imaged with optical coherence tomography (OCT) through the corneoscleral limbus but is currently unable to image the angle from within the ocular anterior chamb ... Full text Link to item Cite

Human aqueous humor exosomes.

Journal Article Exp Eye Res · March 2015 Aqueous humor (AH) is a dynamic intraocular fluid that supports the vitality of tissues that regulate intraocular pressure. We recently discovered that extracellular nanovesicles called exosomes are a major constituent of AH. Exosomes function in extracell ... Full text Link to item Cite

RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.

Journal Article Am J Pathol · February 2015 Ocular hypertension arising from increased resistance to aqueous humor (AH) outflow through the trabecular meshwork is a primary risk factor for open-angle glaucoma, a leading cause of blindness. Ongoing efforts have found little about the molecular and ce ... Full text Link to item Cite

Early Postoperative Increase in Intraocular Pressure

Chapter · January 1, 2015 Early postoperative pressure increases following trabeculectomy surgery can occur from many causes. Careful examination, including slit lamp, gonioscopy, and funduscopy, can help discern the etiology of the pressure elevation. Many of the conditions can be ... Full text Cite

Rho kinase inhibitors for glaucoma treatment - Review.

Journal Article Arq Bras Oftalmol · 2015 Glaucoma is a progressive optic neuropathy characterized by the loss of ganglion cells and their axons. A major risk factor for glaucomatous visual field loss is elevated intraocular pressure (IOP), and several studies have shown that lowering IOP reduces ... Full text Link to item Cite

Simultaneous Implantation of Two Glaucoma Drainage Devices for Uncontrolled Advanced Glaucoma

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Osteogenesis imperfecta and primary open angle glaucoma: genotypic analysis of a new phenotypic association.

Journal Article Mol Vis · 2014 PURPOSE: Osteogenesis imperfecta (OI) is a group of inherited disorders characterized by bone fragility. Ocular findings include blue sclera, low ocular rigidity, and thin corneal thickness. However, there are no documented cases linking OI and primary ope ... Link to item Cite

Rho-kinase inhibitors offer a new approach in the treatment of glaucoma.

Journal Article Expert Opin Investig Drugs · January 2014 INTRODUCTION: Primary open-angle glaucoma (POAG) is a leading cause for worldwide blindness and is characterized by progressive optic nerve damage. The etiology of POAG is unknown, but elevated intraocular pressure (IOP) and advanced age have been identifi ... Full text Link to item Cite

Investigation of known genetic risk factors for primary open angle glaucoma in two populations of African ancestry.

Journal Article Invest Ophthalmol Vis Sci · September 17, 2013 PURPOSE: Multiple genes have been associated with primary open angle glaucoma (POAG) in Caucasian populations. We now examine the association of these loci in populations of African ancestry, populations at particularly high risk for POAG. METHODS: We geno ... Full text Link to item Cite

PEDF Effects on Outflow Facility

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

FOXOs in the Mouse Visual System

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

Upregulation of miR-146a in retina in rodent models of elevated intraocular pressure

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

The Protective effects of Resveratrol in Experimental Retinal Detachment

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

Optimizing gene transfer to conventional outflow cells in living mouse eyes.

Journal Article Exp Eye Res · April 2013 The mouse eye has physiological and genetic advantages to study conventional outflow function. However, its small size and shallow anterior chamber presents technical challenges to efficient intracameral delivery of genetic material to conventional outflow ... Full text Link to item Cite

The effect of Rho-associated kinase inhibition on the ocular penetration of timolol maleate.

Journal Article Invest Ophthalmol Vis Sci · February 7, 2013 PURPOSE: To assess the effects of Rho-associated kinase (ROCK) inhibition on the intraocular penetration of timolol maleate. METHODS: Ex vivo porcine corneal penetration of timolol maleate, sotalol hydrochloride, or brinzolamide incubated with or without Y ... Full text Link to item Cite

Osteogenesis Imperfecta and the Eye

Chapter · January 1, 2013 While the many skeletal, auditory, dental and other anomalies in osteogenesis imperfecta (OI) have been well documented in the medical literature, the eye and the visual system are also commonly affected in patients with OI. As type I collagen fibers are a ... Full text Cite

The Miotics

Chapter · 2013 Cite

Protective effects of resveratrol in experimental retinal detachment.

Journal Article PLoS One · 2013 BACKGROUND: Oxidative stress is one of the major factors that trigger photoreceptor apoptosis. To investigate whether resveratrol, a potent antioxidant and small molecule activator of the FoxO pathway, would be neuroprotective against photoreceptor cell de ... Full text Link to item Cite

The Tube Versus Trabeculectomy Study: interpretation of results and application to clinical practice.

Journal Article Curr Opin Ophthalmol · March 2012 PURPOSE OF REVIEW: The Tube Versus Trabeculectomy (TVT) Study is a multicenter randomized clinical trial comparing the safety and efficacy of tube-shunt surgery to trabeculectomy with mitomycin C (MMC) in eyes with previous cataract and/or failed glaucoma ... Full text Link to item Cite

Low prevalence of myocilin mutations in an African American population with primary open-angle glaucoma.

Journal Article Mol Vis · 2012 PURPOSE: Mutations in the myocilin gene (MYOC) are associated with primary open-angle glaucoma (POAG) in many different populations. This study represents the first large survey of MYOC mutations in an African American population. METHODS: We recruited 529 ... Link to item Cite

Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure.

Journal Article PLoS One · 2012 Primary open-angle glaucoma is the second leading cause of blindness in the United States and is commonly associated with elevated intraocular pressure (IOP) resulting from diminished aqueous humor (AH) drainage through the trabecular pathway. Developing e ... Full text Link to item Cite

Resveratrol prevention of oxidative stress damage to lens epithelial cell cultures is mediated by forkhead box O activity.

Journal Article Invest Ophthalmol Vis Sci · June 21, 2011 Featured Publication PURPOSE: To evaluate the potential role that FoxO transcription factors play in modulating resveratrol's protective effects against oxidative stress in lens epithelial cells. METHODS: Primary human or porcine lens epithelial cells (LECs) were treated with ... Full text Link to item Cite

GALC deletions increase the risk of primary open-angle glaucoma: the role of Mendelian variants in complex disease.

Journal Article PLoS One · 2011 DNA copy number variants (CNVs) have been reported in many human diseases including autism and schizophrenia. Primary Open Angle Glaucoma (POAG) is a complex adult-onset disorder characterized by progressive optic neuropathy and vision loss. Previous studi ... Full text Link to item Cite

Genome-wide linkage scan for primary open angle glaucoma: influences of ancestry and age at diagnosis.

Journal Article PLoS One · 2011 Primary open-angle glaucoma (POAG) is the most common form of glaucoma and one of the leading causes of vision loss worldwide. The genetic etiology of POAG is complex and poorly understood. The purpose of this work is to identify genomic regions of interes ... Full text Link to item Cite

Genetics of adult glaucoma.

Journal Article Int Ophthalmol Clin · 2011 Full text Link to item Cite

LOXL1 expression in lens capsule tissue specimens from individuals with pseudoexfoliation syndrome and glaucoma.

Journal Article Mol Vis · November 2, 2010 Featured Publication PURPOSE: To study lysyl oxidase-like 1 (LOXL1) expression in freshly collected lens capsules from pseudoexfoliation syndrome (XFS), pseudoexfoliation glaucoma (XFG), and normal cataract control individuals. We also investigated the effects of four glaucoma ... Link to item Cite

In vivo Viral Infusion Method for Gene Delivery to Trabecular Meshwork Cells in Rat Eyes

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2010 Link to item Cite

FOXO Protein Expression is Down-Regulated With Aging in the Lens

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2010 Link to item Cite

The Anterior Segment Effects of a Conditional Dicer Knockout in a Rodent Model

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2010 Link to item Cite

Review of results from the Tube Versus Trabeculectomy Study.

Journal Article Curr Opin Ophthalmol · March 2010 PURPOSE OF REVIEW: The Tube Versus Trabeculectomy (TVT) Study is a multicenter randomized clinical trial comparing the safety and efficacy of tube-shunt surgery to trabeculectomy with mitomycin (MMC) in eyes with previous cataract and/or unsuccessful glauc ... Full text Link to item Cite

Descemet's stripping automated endothelial keratoplasty in a patient with four glaucoma tubes.

Journal Article Ann Ophthalmol (Skokie) · 2010 Featured Publication Descemet's stripping automated endothelial keratoplasty (DSAEK) is an increasingly popular techniquefor transplanting corneal endothelial cells. The presence of glaucoma, and especially glaucoma tubes, however, renders the DSAEK procedure more challenging. ... Link to item Cite

Extracellular release of ATP mediated by cyclic mechanical stress leads to mobilization of AA in trabecular meshwork cells.

Journal Article Invest Ophthalmol Vis Sci · December 2009 Featured Publication PURPOSE: To investigate the mechanisms that mediate the release of ATP induced by cyclic mechanical stress (CMS) and the role of extracellular ATP in the mobilization of arachidonic acid (AA) and prostaglandin secretion. METHODS: Porcine trabecular meshwor ... Full text Link to item Cite

Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits.

Journal Article J Ocul Pharmacol Ther · June 2009 Featured Publication AIM: Poor topical bioavailability and ocular irritation have impeded the development of the diuretic, ethacrynic acid (ECA) as a clinically useful ocular hypotensive for the treatment of glaucoma. Thus, the development of analogs and prodrugs of analogs wi ... Full text Link to item Cite

Genetics of pseudoexfoliation syndrome.

Journal Article Curr Opin Ophthalmol · March 2009 Featured Publication PURPOSE OF REVIEW: Pseudoexfoliation syndrome (XFS) is a late-onset and complex disorder that is strongly associated with the development of glaucoma. The purpose of this review is to discuss the inheritance patterns and recent genetic advances in the stud ... Full text Link to item Cite

Surgical management of hypotony owing to overfiltration in eyes receiving glaucoma drainage devices.

Journal Article J Glaucoma · 2009 Featured Publication PURPOSE: To assess rates of surgical revision of glaucoma drainage devices (GDDs) from hypotony owing to overfiltration and its management. DESIGN: Retrospective case series. METHODS: Demographic characteristics, type of GDD implanted, type of surgical rev ... Full text Link to item Cite

Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells.

Journal Article Food Chem Toxicol · January 2009 Featured Publication Elevated intraocular pressure (IOP) constitutes the best characterized risk for primary open-angle glaucoma (POAG). Elevated IOP is believed to result from an increase in aqueous humor outflow resistance at the level of the trabecular meshwork (TM)/Schlemm ... Full text Link to item Cite

Glaucoma patients' trust in the physician.

Journal Article J Ophthalmol · 2009 Featured Publication Objectives. To describe glaucoma patients' trust in the physician and to test the hypothesis that increased interpersonal trust is associated with increased medication adherence. Methods. One hundred ninety-five subjects with open-angle glaucoma seen by mu ... Full text Link to item Cite

Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations.

Journal Article Invest Ophthalmol Vis Sci · August 2008 Featured Publication PURPOSE: Significant association has recently been reported between pseudoexfoliation glaucoma (XFG) and two single-nucleotide polymorphisms (SNPs), rs3825942, and rs1048661, in the lysyl oxidase-like 1 gene (LOXL1). The purpose of this study was to invest ... Full text Link to item Cite

Health literacy and vision-related quality of life.

Journal Article Br J Ophthalmol · June 2008 Featured Publication BACKGROUND: Non-visual factors influence a person's vision-related quality of life (VRQoL). The purpose of this study was to assess the relationship between health literacy and VRQoL in glaucoma patients. METHODS: One hundred and ninety-five subjects with ... Full text Link to item Cite

Use of a standardized patient satisfaction questionnaire to assess the quality of care provided by ophthalmology residents.

Journal Article Ophthalmology · April 2008 Featured Publication PURPOSE: To develop and use a standardized patient satisfaction questionnaire (PSQ) to address two study questions: (1) What is the overall level of satisfaction with resident care? (2) Can the study questionnaire be used to detect differences in the level ... Full text Link to item Cite

Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma.

Journal Article Mol Vis · January 29, 2008 Featured Publication PURPOSE: To identify if recently described LOXL1 (lysyl oxidase-like 1) polymorphisms are associated with pseudoexfoliation glaucoma (XFG) in a United States (U.S.) Caucasian patient population. METHODS: Individuals with XFG were identified using standard ... Link to item Cite

Optineurin coding variants in Ghanaian patients with primary open-angle glaucoma.

Journal Article Mol Vis · 2008 Featured Publication PURPOSE: Coding variants in the optineurin gene (OPTN, GLC1E) have been reported to play a role in primary open-angle glaucoma (POAG) in various populations. This study investigated the role of OPTN sequence variants in patients with POAG in Ghana (West Af ... Link to item Cite

Glaucoma genetics.

Journal Article Int Ophthalmol Clin · 2008 Featured Publication Full text Link to item Cite

Proteomic analysis of regenerated rabbit lenses reveal crystallin expression characteristic of adult rabbits.

Journal Article Mol Vis · 2008 Featured Publication PURPOSE: To explore lens crystallin characteristics and morphology of rabbit regenerated lenses in comparison with wild type natural lenses by means of proteomic analysis and histological assay. METHODS: The lens regeneration model of the New Zealand rabbi ... Link to item Cite

Exposure of Ex-PRESS Miniature Glaucoma Devices: case series and technique for tube shunt removal.

Journal Article J Glaucoma · December 2007 PURPOSE: To report a series of cases involving Ex-PRESS Miniature Glaucoma Device exposure and discuss the surgical techniques we used to remove the shunts. METHODS: A retrospective chart review was performed to identify all patients who were referred for ... Full text Link to item Cite

Mechanisms of action and efficacy of argon laser trabeculoplasty and selective laser trabeculoplasty.

Journal Article Curr Opin Ophthalmol · March 2007 PURPOSE OF REVIEW: Since the 1980s, laser trabeculoplasty has served as an effective way to lower intraocular pressure in patients with primary or secondary open angle glaucomas, both as an initial therapy or in conjunction with hypotensive medications. Th ... Full text Link to item Cite

In response [3]

Other Journal of Glaucoma · March 1, 2007 Full text Cite

Transscleral diffusion of ethacrynic acid and sodium fluorescein.

Journal Article Mol Vis · February 22, 2007 PURPOSE: One of the current limitations in developing novel glaucoma drugs that target the trabecular meshwork (TM) is the induced corneal toxicity from eyedrop formulations. To avoid the corneal toxicity, an alternative approach would be to deliver TM dru ... Link to item Cite

Surgical complications in the Tube Versus Trabeculectomy Study during the first year of follow-up.

Journal Article Am J Ophthalmol · January 2007 PURPOSE: To describe the intraoperative and postoperative complications encountered during the first year of follow-up in the Tube Versus Trabeculectomy (TVT) Study. DESIGN: Multicenter randomized clinical trial. SETTING: Seventeen clinical centers. STUDY ... Full text Link to item Cite

Treatment outcomes in the tube versus trabeculectomy study after one year of follow-up.

Journal Article Am J Ophthalmol · January 2007 PURPOSE: To report one-year results of the Tube Versus Trabeculectomy (TVT) Study. DESIGN: Multicenter randomized clinical trial. SETTING: 17 Clinical Centers. STUDY POPULATION: Patients 18 to 85 years of age who had previous trabeculectomy and/or cataract ... Full text Link to item Cite

Juvenile bilateral lens dislocation and glaucoma associated with a novel mutation in the fibrillin 1 gene.

Journal Article Mol Vis · August 28, 2006 PURPOSE: To describe the clinical, ocular, and genetic findings in multiple members of a family with early-onset and bilateral lens dislocation, clinical corneal guttae, and glaucoma. METHODS: All family members underwent complete physical and ophthalmic e ... Link to item Cite

Health literacy and adherence to glaucoma therapy.

Journal Article Am J Ophthalmol · August 2006 PURPOSE: To describe the health literacy of subjects with open angle glaucoma and to investigate the hypothesis that low health literacy is associated with poor glaucoma medication adherence. DESIGN: Cross-sectional patient survey and concomitant chart rev ... Full text Link to item Cite

Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue.

Journal Article Mol Vis · July 12, 2006 PURPOSE: To contrast genome-wide gene expression profiles of cultured human trabecular meshwork (HTM) cells to that of control and primary open angle glaucoma (POAG) HTM tissues. METHODS: Cultured HTM cells, HTM tissue dissected from control donors, and HT ... Link to item Cite

A modeled economic analysis of a digital tele-ophthalmology system as used by three federal health care agencies for detecting proliferative diabetic retinopathy.

Journal Article Telemed J E Health · December 2005 The objective of this study was to compare, using a 12-month time frame, the cost-effectiveness of a non-mydriatic digital tele-ophthalmology system (Joslin Vision Network) versus traditional clinic-based ophthalmoscopy examinations with pupil dilation to ... Full text Link to item Cite

Induction of TGF-beta1 in the trabecular meshwork under cyclic mechanical stress.

Journal Article J Cell Physiol · December 2005 The pathophysiological mechanisms involved in the failure of the trabecular meshwork (TM) to maintain normal levels of aqueous outflow in glaucoma are not yet understood. Aberrant activation of the transforming growth factor beta-1 (TGF-beta1) pathway has ... Full text Link to item Cite

High failure rate associated with 180 degrees selective laser trabeculoplasty.

Journal Article J Glaucoma · October 2005 PURPOSE: To determine the efficacy of selective laser trabeculoplasty (SLT) in a tertiary care referral center. PATIENTS AND METHODS: In this retrospective study of selective laser trabeculoplasty performed by five physicians, 94 eyes from 94 patients were ... Full text Link to item Cite

The tube versus trabeculectomy study: design and baseline characteristics of study patients.

Journal Article Am J Ophthalmol · August 2005 PURPOSE: The Tube Versus Trabeculectomy (TVT) Study will compare the safety and efficacy of nonvalved tube shunt surgery to trabeculectomy with mitomycin C in patients with previous intraocular surgery. DESIGN: Multicenter randomized clinical trial. SETTIN ... Full text Link to item Cite

Lentiviral mediated gene delivery to the anterior chamber of rodent eyes.

Journal Article Mol Vis · June 21, 2005 PURPOSE: To study the in vivo efficiency of lentiviral vectors in delivering genes to the trabecular meshwork (TM) of rodent eyes. METHODS: Lentiviral vectors were constructed using the elongation factor 1 alpha (EF-1alpha) promoter driving expression of t ... Link to item Cite

Author reply

Conference American Journal of Ophthalmology · March 2005 Full text Cite

Cellular senescence in the glaucomatous outflow pathway.

Journal Article Exp Gerontol · 2005 The mechanisms responsible for the progressive malfunction of the trabecular meshwork (TM)-Schlemm's canal (SC) conventional outflow pathway tissue in primary open angle glaucoma (POAG) are still not fully understood. To determine whether POAG is character ... Full text Link to item Cite

Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter.

Journal Article Invest Ophthalmol Vis Sci · January 2005 PURPOSE: To compare the gene expression profile of trabecular meshwork (TM) and Schlemm's canal (SC) primary cultures and to identify promoters for targeting gene expression to specific cells in the outflow pathway. METHODS: The differential gene expressio ... Full text Link to item Cite

Novel anti-glaucoma formulations of ethacrynic acid containing chitosan

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · January 1, 2005 Link to item Cite

The effect of surgery on intraocular pressure fluctuations with electroconvulsive therapy in a patient with severe glaucoma.

Journal Article J ECT · December 2004 We sought to report glaucoma surgery as a possibly protective measure in patients with elevated intraocular pressure (IOP) during electroconvulsive therapy (ECT). An interventional case report is reported. IOP measurements were taken in patients with progr ... Full text Link to item Cite

Effects of donor age on proteasome activity and senescence in trabecular meshwork cells.

Journal Article Biochem Biophys Res Commun · October 22, 2004 The mechanisms involved in the progressive malfunction of the trabecular meshwork (TM) in glaucoma are not yet understood. To study age-related changes in human TM cells, we isolated primary TM cell cultures from young (ages 9, 14, and 25) and old (ages 66 ... Full text Link to item Cite

Early rapid rise in intraocular pressure after intravitreal triamcinolone acetonide injection.

Journal Article Am J Ophthalmol · August 2004 PURPOSE: To report the occurrences of early rapid increases in intraocular (IOP) after intravitreal glucocorticoid injection. DESIGN: Observational case series. METHODS: We retrospectively reviewed the records of three patients seen and treated at Duke Eye ... Full text Link to item Cite

Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.

Journal Article Biomaterials · August 2004 Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure. However, conventional methods of ECA administration may cause toxicity to normal eye tissues and are inconvenient to patients. Therefore, we developed and characterize ... Full text Link to item Cite

Glaucoma in Ghana, West Africa: clinical features and the role of mutations in Myocilin.

Journal Article Ophthalmol Clin North Am · December 2003 POAG is a severely debilitating disease in West Africa. Currently, many patients seem to be misclassified as having POAG who in fact have CACG. Improved examination techniques, including routine gonioscopy, would increase diagnostic accuracy and improve tr ... Full text Link to item Cite

Gene expression profile in a novel cell type in primary cultures of human trabecular meshwork

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · May 1, 2003 Link to item Cite

Correlation among retinal thickness, optic disc, and visual field in glaucoma patients and suspects: a pilot study.

Journal Article J Glaucoma · April 2003 OBJECTIVE: To correlate losses of retinal thickness in the perifoveal area in glaucoma as measured by the Retinal Thickness Analyzer (Talia Technology Ltd, Israel) with optic nerve and visual field changes in glaucoma patients and suspects. METHODS: Observ ... Full text Link to item Cite

Readability of ocular medication inserts.

Journal Article J Glaucoma · February 2003 OBJECTIVE: To determine the readability of ocular medication inserts and whether they are an appropriate source of medication information for patients. MATERIALS AND METHODS: The Flesch-Kincaid and SMOG readability formulas were used to calculate the reada ... Full text Link to item Cite

Using the arteriolar Pressure Attenuation Index to predict ocular hypertension progression to open-angle glaucoma.

Journal Article Arch Ophthalmol · January 2003 BACKGROUND: Vascular phenomena are considered important to optic nerve and visual field progression in open-angle glaucoma (OAG). A recently described formulation, the Pressure Attenuation Index (PAI), links arteriolar caliber variations to pressure loss a ... Full text Link to item Cite

Prevalence of myocilin mutations in adults with primary open-angle glaucoma in Ghana, West Africa.

Journal Article J Glaucoma · October 2002 PURPOSE: Investigators have noted that primary open-angle glaucoma (POAG) in West Africa has an earlier age of onset and appears to be more clinically severe than in the United States and Europe. Primary open-angle glaucoma patients with mutations in myoci ... Full text Link to item Cite

Survey of glaucoma in an eye clinic in Ghana, West Africa.

Journal Article J Glaucoma · October 2002 PURPOSE: To report the various types of glaucoma among West African patients presenting to an eye clinic in Ghana. METHODS: A complete evaluation was performed in 198 consecutive Ghanaian glaucoma patients. Main outcome measures included intraocular pressu ... Full text Link to item Cite

Early clinical experience with the ahmed glaucoma bi-plate

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · May 1, 2002 Link to item Cite

The effects of drying on central corneal thickness

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · May 1, 2002 Link to item Cite

Generation of gene arrays from human trabecular meshwork cDNA libraries

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · May 1, 2002 Link to item Cite

Attitudes toward genetic testing for glaucoma: A survey of patients

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · May 1, 2002 Link to item Cite

Novel myocilin mutations in individuals with POAG from West Africa.

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 2001 Link to item Cite

Types of glaucoma in a Ghanaian clinic.

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 2001 Link to item Cite

A duplication in chromosome 4q35 is associated with hereditary benign intraepithelial dyskeratosis.

Journal Article Am J Hum Genet · February 2001 Hereditary benign intraepithelial dyskeratosis (HBID) is an autosomal dominant disorder characterized by elevated epithelial plaques on the ocular and oral mucous membranes. It has been reported primarily, but not exclusively, in individuals of American In ... Full text Link to item Cite

Phenotypic characteristics of hereditary benign intraepithelial dyskeratosis (HBID).

Conference AMERICAN JOURNAL OF HUMAN GENETICS · October 1, 2000 Link to item Cite

Who comes to community eye screenings? A survey.

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 2000 Link to item Cite

Genetic mapping of a syndrome of early-onset lens dislocation

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 2000 Link to item Cite

A novel inherited syndrome of early lens dislocation

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1999 Link to item Cite

Comparison of intraocular pressure lowering by topical and systemic carbonic anhydrase inhibitors in the rabbit.

Journal Article J Ocul Pharmacol Ther · February 1999 We compared the effect on intraocular pressure (IOP) of maximal doses of a topical carbonic anhydrase inhibitor (CAI) at acidic and alkaline pH where it is maximally effective with full systemic CA inhibition in ocular normotensive New Zealand Albino rabbi ... Full text Link to item Cite