Scholars@Duke
Evan Robert Myers

Evan Robert Myers

Walter L. Thomas Distinguished Professor of Obstetrics and Gynecology in the School of Medicine
Obstetrics and Gynecology, Women's Community & Population Health
evan.myers@duke.edu
Box 3279 Med Ctr, Durham, NC 27710
244 Baker House, Durham, NC 27710

Selected Publications

Weight-loss therapy in patients with obesity with endometrial intraepithelial neoplasia and uterine cancer.

Journal Article Gynecol Oncol · November 2024 OBJECTIVE: Although obesity is an important risk factor for endometrial intraepithelial neoplasia (EIN) and uterine cancer, little is known about the trends in use of weight-loss therapy for patients with obesity with EIN and uterine cancer. We examined th ... Full text Link to item Cite

Too much of a good thing? Projecting the need for gynecologic oncologists over the next 20 years.

Journal Article Gynecologic oncology · November 2024 ObjectiveTo estimate the effect of growth in gynecologic oncology fellowships in the United States on surgical volume for trainees and practicing gynecologic oncologists over the next 20 years.MethodsUsing 2010-2019 age-specific gynecolog ... Full text Cite

Reproductive Outcomes of Patients Undergoing Uterine Artery Embolization for Uterine Fibroids: Proceedings from The Dr. James B. Spies Summit for Uterine Fibroid Research-A Society of Interventional Radiology Foundation Research Consensus Panel.

Journal Article J Vasc Interv Radiol · September 2024 Reproductive outcomes after uterine artery embolization (UAE) for the treatment of uterine fibroids are challenging to study, leaving several unanswered questions surrounding the future fertility of patients undergoing the procedure. Subject matter experts ... Full text Link to item Cite

Trends in uterine cancer incidence in the United States: The contribution of age, period and cohort effects.

Journal Article Gynecol Oncol · August 2024 OBJECTIVE: In the U.S., uterine cancer incidence is rising, with racial and ethnic minorities experiencing the largest increases. We performed age-period-cohort analyses using novel methods to examine the contribution of age at diagnosis (age), year of dia ... Full text Link to item Cite

Estimated National Cost of Pelvic Organ Prolapse Surgery in the United States.

Journal Article Obstet Gynecol · March 1, 2024 OBJECTIVE: To estimate the national cost of pelvic organ prolapse (POP) surgery in the United States. METHODS: In this cross-sectional, population-based study, we used the 2016-2018 Healthcare Cost and Utilization Project National Inpatient Samples and Nat ... Full text Link to item Cite

Geographic variation in the rate and route of hysterectomy for benign disease in the USA: A retrospective cross-sectional study.

Journal Article BJOG · November 2023 OBJECTIVES: To describe population rate of hysterectomy for benign disease in the USA, including geographic variation across states and Hospital Service Areas (HSAs; areas defined by common patient flows to healthcare facilities). DESIGN: Cross-sectional s ... Full text Link to item Cite

Influenza Vaccination Implementation in Sri Lanka: A Cost-Effectiveness Analysis.

Journal Article Vaccines (Basel) · May 3, 2023 Influenza causes an estimated 3 to 5 million cases of severe illness annually, along with substantial morbidity and mortality, particularly in low- and middle-income countries (LMICs). Currently, Sri Lanka has no influenza vaccination policies and does not ... Full text Open Access Link to item Cite

A Comparative Analysis of Health-Related Quality of Life 1 Year Following Myomectomy or Uterine Artery Embolization: Findings from the COMPARE-UF Registry.

Journal Article J Womens Health (Larchmt) · April 2023 Objective: To compare 12-month post-treatment health-related quality of life (HR-QoL) and symptom severity (SS) changes among patients with symptomatic uterine fibroids (SUF) not seeking fertility and undergo a hysterectomy, abdominal myomectomy (AM), or u ... Full text Link to item Cite

Model-Projected Cost-Effectiveness of Adult Hearing Screening in the USA.

Journal Article J Gen Intern Med · March 2023 BACKGROUND: While 60% of older adults have hearing loss (HL), the majority have never had their hearing tested. OBJECTIVE: We sought to estimate long-term clinical and economic effects of alternative adult hearing screening schedules in the USA. DESIGN: Mo ... Full text Link to item Cite

The potential cost-effectiveness of novel cord blood therapies in children with autism spectrum disorder.

Journal Article PLoS One · 2023 OBJECTIVE: To model the long-term clinical and economic outcomes of potential cord blood therapy in autism spectrum disorder (ASD). STUDY DESIGN: Markov microsimulation of ASD over the lifespan was used to compare two strategies: 1) standard of care (SOC), ... Full text Link to item Cite

Cost-effectiveness of Strategies for Postpartum Glucose Intolerance Testing

Journal Article North Carolina Medical Journal · January 1, 2023 Background Abnormal glucose metabolism after gestational diabetes mellitus can persist postpartum. This study compares the cost and effectiveness of 4 postpartum glucose intolerance screening strategies and their influencing variables. Methods A decision m ... Full text Cite

Estimated Monetary Value of Future Research Clarifying Uncertainties Around the Optimal Adult Hearing Screening Schedule.

Journal Article JAMA Health Forum · November 4, 2022 IMPORTANCE: Adult hearing screening is not routinely performed, and most individuals with hearing loss (HL) have never had their hearing tested as adults. OBJECTIVE: To project the monetary value of future research clarifying uncertainties around the optim ... Full text Link to item Cite

Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium.

Journal Article Br J Cancer · November 2022 BACKGROUND: Obesity disproportionately affects African American (AA) women and has been shown to increase ovarian cancer risk, with some suggestions that the association may differ by race. METHODS: We evaluated body mass index (BMI) and invasive epithelia ... Full text Link to item Cite

Racial disparities in epithelial ovarian cancer survival: An examination of contributing factors in the Ovarian Cancer in Women of African Ancestry consortium.

Conference Int J Cancer · October 15, 2022 Black women diagnosed with epithelial ovarian cancer have poorer survival compared to white women. Factors that contribute to this disparity, aside from socioeconomic status and guideline-adherent treatment, have not yet been clearly identified. We examine ... Full text Link to item Cite

Race Differences in the Associations between Menstrual Cycle Characteristics and Epithelial Ovarian Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2, 2022 BACKGROUND: Menstrual cycle characteristics-including age at menarche and cycle length- have been associated with ovarian cancer risk in White women. However, the associations between menstrual cycle characteristics and ovarian cancer risk among Black wome ... Full text Link to item Cite

Cost-effectiveness of Pulmonary Rehabilitation Among US Adults With Chronic Obstructive Pulmonary Disease.

Journal Article JAMA Netw Open · June 1, 2022 IMPORTANCE: Pulmonary rehabilitation (PR) after exacerbation of chronic obstructive pulmonary disease (COPD) is effective in reducing COPD hospitalizations and mortality while improving health-related quality of life, yet use of PR remains low. Estimates o ... Full text Link to item Cite

Cost comparison of using reusable versus disposable equipment for retinopathy of prematurity screening rounds.

Conference J AAPOS · April 2022 Retinopathy of prematurity (ROP) screening rounds have been linked to pathogen transmission and serious adverse outcomes in neonatal intensive care units (NICUs). Using Monte Carlo simulations, we found that it is more likely less expensive to use reusable ... Full text Link to item Cite

Development and validation of DeciBHAL-US: A novel microsimulation model of hearing loss across the lifespan in the United States.

Journal Article EClinicalMedicine · February 2022 BACKGROUND: Hearing loss affects over 50% of people in the US across their lifespan and there is a lack of decision modeling frameworks to inform optimal hearing healthcare delivery. Our objective was to develop and validate a microsimulation model of hear ... Full text Link to item Cite

Estimated Prevalence of Risk Factors for Preeclampsia Among Individuals Giving Birth in the US in 2019.

Journal Article JAMA Netw Open · January 4, 2022 IMPORTANCE: Low-dose aspirin (LDA) is one of the few evidence-based interventions for preventing preeclampsia, which is a leading cause of maternal or fetal morbidity and mortality. Current guidelines recommend LDA based on the presence of risk factors for ... Full text Link to item Cite

Surveillance for gestational trophoblastic neoplasia following molar pregnancy: a cost-effectiveness analysis.

Journal Article Am J Obstet Gynecol · November 2021 BACKGROUND: Historically, published guidelines for care after molar pregnancy recommended monitoring human chorionic gonadotropin levels for the development of gestational trophoblastic neoplasia until normal and then for 6 months after the first normal hu ... Full text Link to item Cite

Oocyte cryopreservation versus ovarian tissue cryopreservation for adult female oncofertility patients: a cost-effectiveness study.

Journal Article J Assist Reprod Genet · September 2021 PURPOSE: In December 2019, the American Society for Reproductive Medicine designated ovarian tissue cryopreservation (OTC) as no longer experimental and an alternative to oocyte cryopreservation (OC) for women receiving gonadotoxic therapy. Anticipating in ... Full text Link to item Cite

Incremental healthcare resource utilization and costs for patients with cervical, vaginal, vulvar, anal, and oropharyngeal cancer in the United States.

Journal Article Curr Med Res Opin · September 2021 INTRODUCTION: Human papillomavirus (HPV) cause cancers in a variety of anatomic sites presenting at various stages of disease. Current economic assessments rely on HPV-related cancer cost estimates from data prior to the launch of the nonavalent HPV vaccin ... Full text Link to item Cite

A Scoping Review of Unintended Pregnancy in Active Duty United States Military Women.

Journal Article Womens Health Issues · August 25, 2021 INTRODUCTION: The purpose of this scoping review was to apply the Social Ecological Model for Military Women's Health to literature on unintended pregnancy (UIP) to answer the question: In United States active duty military women (population) with the pote ... Full text Link to item Cite

First- and second-degree family history of ovarian and breast cancer in relation to risk of invasive ovarian cancer in African American and white women.

Journal Article Int J Cancer · June 15, 2021 Family history (FH) of ovarian cancer and breast cancer are well-established risk factors for ovarian cancer, but few studies have examined this association in African American (AA) and white women by histotype. We assessed first- and second-degree FH of o ... Full text Link to item Cite

Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium.

Journal Article J Natl Cancer Inst · June 1, 2021 BACKGROUND: The causes of racial disparities in epithelial ovarian cancer (EOC) incidence remain unclear. Differences in the prevalence of ovarian cancer risk factors may explain disparities in EOC incidence among African American (AA) and White women. MET ... Full text Link to item Cite

Protocol for implementation of an evidence based parentally administered intervention for preterm infants.

Journal Article BMC Pediatr · March 24, 2021 BACKGROUND: Multi-sensory behavioral interventions for preterm infants have the potential to accelerate feeding, growth, and optimize developmental trajectories and increase parents' interactive engagement with their infants. However, few neonatal intensiv ... Full text Link to item Cite

Venous thromboembolism incidence among patients recommended for pharmacologic thromboembolism prophylaxis after cesarean delivery in selected guidelines.

Journal Article J Thromb Haemost · March 2021 BACKGROUND: Multiple guidelines regarding risk stratification for venous thromboembolism (VTE) incidence following cesarean delivery have been promulgated. OBJECTIVE: To estimate the percentage of cesarean delivery patients for which pharmacologic VTE woul ... Full text Link to item Cite

Black Women Are More Likely Than White Women to Schedule a Uterine-Sparing Treatment for Leiomyomas.

Journal Article J Womens Health (Larchmt) · March 2021 Background: To evaluate differences in the proportion of uterine fibroid (UF) treatments that are uterine-sparing between Black women and White women and identify factors that could explain disparities. Methods: Women at age 18-54 years who were enrolled f ... Full text Link to item Cite

Prevalence, incidence, and natural history of HPV infection in adult women ages 24 to 45 participating in a vaccine trial.

Journal Article Papillomavirus Res · December 2020 OBJECTIVES: The natural history of human papillomavirus (HPV) infection has been studied extensively in young women; this study investigated HPV infection in adult women. METHODS: Data from 3817 women aged 24-45 years in a global trial of the 4-valent HPV ... Full text Link to item Cite

Cost-effectiveness analysis comparing "PARP inhibitors-for-all" to the biomarker-directed use of PARP inhibitor maintenance therapy for newly diagnosed advanced stage ovarian cancer.

Journal Article Gynecol Oncol · November 2020 OBJECTIVES: Clinical trials evaluating universal PARP inhibitor (PARPi) frontline maintenance therapy for advanced stage ovarian cancer have reported progression-free survival (PFS) benefit. It is unclear whether PARPi maintenance therapy will universally ... Full text Link to item Cite

Addressing heterogenous outcomes in uterine fibroid research: a call to action.

Journal Article Am J Obstet Gynecol · July 2020 Uterine fibroid tumors are the most common benign pelvic tumors in women, with complications that include heavy menstrual bleeding, pelvic pain, reproductive complications, and bulk-related symptoms. Although the majority of uterine fibroid tumors are asym ... Full text Link to item Cite

Publisher Correction: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.

Journal Article Nat Commun · April 28, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

Short-term quality of life after myomectomy for uterine fibroids from the COMPARE-UF Fibroid Registry.

Journal Article Am J Obstet Gynecol · April 2020 BACKGROUND: Uterine fibroids may decrease quality of life in a significant proportion of affected women. Myomectomy offers a uterine-sparing treatment option for patients with uterine fibroids that can be performed abdominally, laparoscopically (with or wi ... Full text Link to item Cite

Comparative effectiveness of hysterectomy versus myomectomy on one-year health-related quality of life in women with uterine fibroids.

Journal Article Fertil Steril · March 2020 OBJECTIVE: To compare long-term health-related quality of life (HRQOL) 1 year after hysterectomy or myomectomy for treatment of uterine fibroids (UFs) and to determine whether route of procedure, race, or age affected improvements in HRQOL. DESIGN: Prospec ... Full text Link to item Cite

Economic Value of Lost Productivity Attributable to Human Papillomavirus Cancer Mortality in the United States.

Journal Article Front Public Health · 2020 Objectives: To estimate years of potential life lost (YPLL) and present value of future lost productivity (PVFLP) associated with premature mortality due to HPV-attributable cancers, specifically those targeted by nonavalent HPV (9vHPV) vaccination, in the ... Full text Link to item Cite

Simulation model of the relationship between cesarean section rates and labor duration.

Journal Article Health Care Manag Sci · December 2019 Cesarean delivery is the most common major abdominal surgery in many parts of the world, and it accounts for nearly one-third of births in the United States. For a patient who requires a C-section, allowing prolonged labor is not recommended because of the ... Full text Link to item Cite

Perspectives on the Costs of Cancer Care: A Survey of the American Society of Breast Surgeons.

Conference Ann Surg Oncol · October 2019 BACKGROUND: Cancer treatment costs are not routinely addressed in shared decisions for breast cancer surgery. Thus, we sought to characterize cost awareness and communication among surgeons treating breast cancer. METHODS: We conducted a self-administered, ... Full text Link to item Cite

Ovarian Cancer in Women of African Ancestry (OCWAA) consortium: a resource of harmonized data from eight epidemiologic studies of African American and white women.

Journal Article Cancer Causes Control · September 2019 PURPOSE: Although the incidence rate of epithelial ovarian cancer (EOC) is somewhat lower in African American (AA) than white women, survival is worse. The Ovarian Cancer in Women of African Ancestry (OCWAA) consortium will overcome small, study-specific s ... Full text Link to item Cite

Short-Term Health-Related Quality of Life After Hysterectomy Compared With Myomectomy for Symptomatic Leiomyomas.

Journal Article Obstet Gynecol · August 2019 OBJECTIVE: To compare short-term health-related quality of life (HRQOL) 6-12 weeks after hysterectomy or myomectomy for the treatment of symptomatic leiomyomas. METHODS: We conducted a prospective comparative effectiveness analysis of data. In an existing ... Full text Link to item Cite

Financial Costs and Burden Related to Decisions for Breast Cancer Surgery.

Journal Article J Oncol Pract · August 2019 PURPOSE: Financial toxicity is a well-recognized adverse effect of cancer care, yet little is known about how women consider treatment costs when facing preference-sensitive decisions for breast cancer surgery or how surgical treatment choice affects finan ... Full text Link to item Cite

Policy Changes Key To Promoting Sustainability And Growth Of The Specialty Palliative Care Workforce.

Journal Article Health Aff (Millwood) · June 2019 Specialized palliative care teams improve outcomes for the steadily growing population of people living with serious illness. However, few studies have examined whether the specialty palliative care workforce can meet the growing demand for its services. W ... Full text Link to item Cite

Safety and efficacy of the selective progesterone receptor modulator asoprisnil for heavy menstrual bleeding with uterine fibroids: pooled analysis of two 12-month, placebo-controlled, randomized trials.

Journal Article Hum Reprod · April 1, 2019 STUDY QUESTION: Can asoprisnil, a selective progesterone receptor modulator, provide clinically meaningful improvements in heavy menstrual bleeding (HMB) associated with uterine fibroids with an acceptable safety profile? SUMMARY ANSWER: Uninterrupted trea ... Full text Link to item Cite

Induction of Labor versus Scheduled Cesarean in Morbidly Obese Women: A Cost-Effectiveness Analysis.

Journal Article Am J Perinatol · March 2019 OBJECTIVE: To assess the costs, complication rates, and harm-benefit tradeoffs of induction of labor (IOL) compared to scheduled cesarean delivery (CD) in women with class III obesity. STUDY DESIGN: We conducted a cost analysis of IOL versus scheduled CD i ... Full text Link to item Cite

A 12-month extension study to evaluate the safety and efficacy of asoprisnil in women with heavy menstrual bleeding and uterine fibroids.

Journal Article Hum Reprod Open · 2019 STUDY QUESTION: What is the safety and efficacy profile during long-term (12-24 months) uninterrupted treatment with the selective progesterone receptor modulator asoprisnil, 10 and 25 mg in women with heavy menstrual bleeding (HMB) associated with uterine ... Full text Link to item Cite

The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions.

Journal Article Int J Gynaecol Obstet · December 2018 BACKGROUND: The International Federation of Gynecology and Obstetrics (FIGO) systems for nomenclature of symptoms of normal and abnormal uterine bleeding (AUB) in the reproductive years (FIGO AUB System 1) and for classification of causes of AUB (FIGO AUB ... Full text Link to item Cite

Comparative effectiveness of uterine fibroids procedures using linked medical record and claims data.

Journal Article J Comp Eff Res · December 2018 AIMS: To compare durability of uterus-conserving procedures for symptomatic fibroids in terms of incidence and time to subsequent procedures. PATIENTS & METHODS: We conducted a retrospective database study of 2648 patients having a uterus-conserving proced ... Full text Link to item Cite

Financial Burden Related to Decisions for Breast Cancer Surgery

Conference JOURNAL OF WOMENS HEALTH · November 1, 2018 Link to item Cite

The Comparing Options for Management: PAtient-centered REsults for Uterine Fibroids (COMPARE-UF) registry: rationale and design.

Journal Article Am J Obstet Gynecol · July 2018 BACKGROUND: Uterine fibroids are common in premenopausal women, yet comparative effectiveness research on uterine fibroid treatments is rare. OBJECTIVE: The purpose of this study was to design and establish a uterine fibroid registry based in the United St ... Full text Link to item Cite

Agency for Healthcare Research and Quality Evidence-based Practice Center methods provide guidance on prioritization and selection of harms in systematic reviews.

Journal Article J Clin Epidemiol · June 2018 OBJECTIVES: Systematic reviews should provide balanced assessments of benefits and harms, while focusing on the most important outcomes. Selection of harms to be reviewed can be a challenge due to the potential for large numbers of diverse harms. STUDY DES ... Full text Link to item Cite

Estimating the number of potential family members eligible for BRCA1 and BRCA2 mutation testing in a "Traceback" approach.

Journal Article Genet Epidemiol · February 2018 U.S. guidelines recommend BRCA1/2 mutation testing for women diagnosed with high-grade ovarian cancer (HGOC) to increase recognition of carriers, but most remain unidentified and at risk. Accordingly, an approach termed "Traceback" has been proposed in whi ... Full text Link to item Cite

Estimating Cost-effectiveness of a Multimodal Ovarian Cancer Screening Program in the United States: Secondary Analysis of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).

Journal Article JAMA Oncol · February 1, 2018 IMPORTANCE: The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) is the largest randomized clinical trial to evaluate screening's impact on ovarian cancer mortality, assigning women to multimodal screening (MMS) with serum cancer an ... Full text Link to item Cite

Cost-Effectiveness of Primary Radiation Therapy Versus Radical Prostatectomy for Intermediate- to High-Risk Prostate Cancer.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2018 PURPOSE: To compare, using a cost-effectiveness analysis, the quality-adjusted life expectancy (QALE) and cost between the 2 treatment options for intermediate- to high-risk prostate cancer: (1) radiation (RT) with androgen deprivation therapy (ADT) or (2) ... Full text Link to item Cite

Evidence-based pregnancy testing in clinical trials: Recommendations from a multi-stakeholder development process.

Journal Article PLoS One · 2018 Most clinical trials exclude pregnant women in order to avoid the possibility of adverse embryonic and/or fetal effects. Currently, there are no evidence-based guidelines regarding appropriate methods for identifying early pregnancy among research subjects ... Full text Link to item Cite

Uterine Fibroids: Burden and Unmet Medical Need.

Journal Article Semin Reprod Med · November 2017 Uterine fibroids affect a wide cross-section of the population, with prevalence, symptom severity, and overall disease burden generally higher among black women, likely due to both genetic and environmental factors. Potential symptoms of uterine fibroids i ... Full text Link to item Cite

Cost Effectiveness of Risk-Reducing Mastectomy versus Surveillance in BRCA Mutation Carriers with a History of Ovarian Cancer.

Journal Article Ann Surg Oncol · October 2017 BACKGROUND: The appropriate management of breast cancer risk in BRCA mutation carriers following ovarian cancer diagnosis remains unclear. We sought to determine the survival benefit and cost effectiveness of risk-reducing mastectomy (RRM) among women with ... Full text Link to item Cite

AHRQ series on complex intervention systematic reviews-paper 5: advanced analytic methods.

Journal Article J Clin Epidemiol · October 2017 BACKGROUND AND OBJECTIVE: Advanced analytic methods for synthesizing evidence about complex interventions continue to be developed. In this paper, we emphasize that the specific research question posed in the review should be used as a guide for choosing t ... Full text Link to item Cite

Monte Carlo simulations of randomized clinical trials in epilepsy

Journal Article Annals of Clinical and Translational Neurology · August 1, 2017 Background: The placebo response in epilepsy randomized clinical trials (RCTs) has recently been shown to largely reflect underlying natural variability in seizure frequency. Based on this observation, we sought to explore the parameter space of RCT design ... Full text Cite

Traceback: A Proposed Framework to Increase Identification and Genetic Counseling of BRCA1 and BRCA2 Mutation Carriers Through Family-Based Outreach.

Journal Article J Clin Oncol · July 10, 2017 In May 2016, the Division of Cancer Prevention and the Division of Cancer Control and Population Sciences, National Cancer Institute, convened a workshop to discuss a conceptual framework for identifying and genetically testing previously diagnosed but unr ... Full text Link to item Cite

Choice of Hemodialysis Access in Older Adults: A Cost-Effectiveness Analysis.

Journal Article Clin J Am Soc Nephrol · June 7, 2017 BACKGROUND AND OBJECTIVES: Although arteriovenous fistulas have been found to be the most cost-effective form of hemodialysis access, the relative benefits of placing an arteriovenous fistula versus an arteriovenous graft seem to be least certain for older ... Full text Link to item Cite

Mechanistic mathematical models: An underused platform for HPV research.

Journal Article Papillomavirus Res · June 2017 Health economic modeling has become an invaluable methodology for the design and evaluation of clinical and public health interventions against the human papillomavirus (HPV) and associated diseases. At the same time, relatively little attention has been p ... Full text Link to item Cite

Mortality reduction and cost-effectiveness of performing hysterectomy at the time of risk-reducing salpingo-oophorectomy for prophylaxis against serous/serous-like uterine cancers in BRCA1 mutation carriers.

Journal Article Gynecol Oncol · June 2017 OBJECTIVE: To estimate the survival benefit and cost-effectiveness of performing hysterectomy during risk-reducing salpingo-oophorectomy (RRSO) for BRCA1 mutation carriers. METHODS: Based on a recent prospective cohort study indicating an elevated incidenc ... Full text Link to item Cite

Disparities in Fibroid Incidence, Prognosis, and Management.

Journal Article Obstet Gynecol Clin North Am · March 2017 Health disparities in fibroid prevalence, prognosis, and treatment exist for underserved women. Access to fibroid treatment alternatives can have significant effect on choices and outcomes of fibroid disease. ... Full text Link to item Cite

Cost Comparison of Genetic Testing Strategies in Women With Epithelial Ovarian Cancer.

Journal Article J Oncol Pract · February 2017 PURPOSE: The advent of multigene panels has increased genetic testing options for women with epithelial ovarian cancer (EOC). We designed a decision model to compare costs and probabilities of identifying a deleterious mutation or variant of uncertain sign ... Full text Link to item Cite

Pregnancy Outcomes after Treatment for Cervical Cancer Precursor Lesions: An Observational Study.

Journal Article PLoS One · 2017 OBJECTIVE: To examine whether surgical procedures involving the uterine cervix were associated with pregnancy outcomes, including preterm birth, low birth weight, cesarean delivery and pregnancy loss. DESIGN: Population-based observational study nested in ... Full text Link to item Cite

Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region.

Journal Article Papillomavirus Res · December 2016 BACKGROUND: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region METHODS: Women ages 1 ... Full text Link to item Cite

Efficacy of a Nurse-Delivered Intervention to Prevent and Delay Postpartum Return to Smoking: The Quit for Two Trial.

Journal Article Nicotine Tob Res · October 2016 INTRODUCTION: Most pregnant women who quit smoking return to smoking postpartum. Trials to prevent this return have been unsuccessful. We tested the efficacy of a nurse-delivered intervention in maintaining smoking abstinence after delivery among pregnant ... Full text Link to item Cite

Levonorgestrel Intrauterine Device as an Endometrial Cancer Prevention Strategy in Obese Women: A Cost-Effectiveness Analysis.

Journal Article Obstet Gynecol · October 2016 OBJECTIVE: To estimate the cost-effectiveness of the levonorgestrel intrauterine device (IUD) as an endometrial cancer prevention strategy in obese women. METHODS: A modified Markov model was used to compare IUD placement at age 50 with usual care among wo ... Full text Link to item Cite

Vitamin D Status Relates to Reproductive Outcome in Women With Polycystic Ovary Syndrome: Secondary Analysis of a Multicenter Randomized Controlled Trial.

Journal Article J Clin Endocrinol Metab · August 2016 CONTEXT: Experimental evidence supports a relevance of vitamin D (VitD) for reproduction; however, data in humans are sparse and inconsistent. OBJECTIVE: To assess the relationship of VitD status with ovulation induction (OI) outcomes in women with polycys ... Full text Link to item Cite

An overview and discussion of the Patient-Centered Outcomes Research Institute's decision aid portfolio.

Journal Article J Comp Eff Res · July 2016 Decision aids (DAs) help patients make informed healthcare decisions in a manner consistent with their values and preferences. Despite their promise, DAs developed with public research dollars are not being implemented and adopted in real-world patient car ... Full text Link to item Cite

Unclear Information in Table

Journal Article JAMA · April 5, 2016 Full text Cite

Characterizing the Hospice and Palliative Care Workforce in the U.S.: Clinician Demographics and Professional Responsibilities.

Journal Article J Pain Symptom Manage · March 2016 CONTEXT: Palliative care services are growing at an unprecedented pace. Yet, the characteristics of the clinician population who deliver these services are not known. Information on the roles, motivations, and future plans of the clinician workforce would ... Full text Link to item Cite

Using percentile matching to simulate labor progression and the effect of labor duration on birth complications

Conference Proceedings - Winter Simulation Conference · February 16, 2016 Of the nearly 4 million births that occur each year in the U.S., almost 1 in 3 is a cesarean delivery. Due to the various increased risks associated with cesarean sections (C-sections) and the potential major complications in subsequent pregnancies, a re-e ... Full text Cite

Association Between Patient Characteristics and Treatment Procedure Among Patients With Uterine Leiomyomas.

Journal Article Obstet Gynecol · January 2016 OBJECTIVE: To analyze the association between patient characteristics and the probability of undergoing any uterine-sparing procedure (endometrial ablation, myomectomy, and uterine artery embolization) compared with hysterectomy as the first uterine leiomy ... Full text Link to item Cite

Decision making about infertility treatment: does unlimited access lead to inappropriate treatment?

Journal Article Isr J Health Policy Res · 2016 The proportion of women aged 40-44 undergoing IVF treatment covered by Maccabi Health Services increased between 2011 and 2014. Although age-specific birth rates did not substantially change over this time period, the demographic change was accompanied by ... Full text Link to item Cite

SIMULATION OF LABOR: A STUDY OF THE RELATIONSHIP BETWEEN CESAREAN SECTION RATES AND THE TIME SPENT IN LABOR

Conference 2016 10TH EUROPEAN CONFERENCE ON ANTENNAS AND PROPAGATION (EUCAP) · 2016 Link to item Cite

Future Research Prioritization: Implantable Cardioverter-Defibrillator Therapy in Older Patients.

Journal Article J Gen Intern Med · December 2015 BACKGROUND: Although the implantable cardioverter-defibrillator (ICD) is highly effective therapy for preventing sudden cardiac death, there is considerable uncertainty about its benefits and harms in older patients, especially in the presence of factors, ... Full text Link to item Cite

Trends in Treatment Patterns and Outcomes for Ductal Carcinoma In Situ.

Journal Article J Natl Cancer Inst · December 2015 BACKGROUND: Impact of contemporary treatment of pre-invasive breast cancer (ductal carcinoma in situ [DCIS]) on long-term outcomes remains poorly defined. We aimed to evaluate national treatment trends for DCIS and to determine their impact on disease-spec ... Full text Link to item Cite

Benefits and Harms of Breast Cancer Screening: A Systematic Review.

Journal Article JAMA · October 20, 2015 IMPORTANCE: Patients need to consider both benefits and harms of breast cancer screening. OBJECTIVE: To systematically synthesize available evidence on the association of mammographic screening and clinical breast examination (CBE) at different ages and in ... Full text Link to item Cite

Cost-Effectiveness of High-Risk Human Papillomavirus Testing With Messenger RNA Versus DNA Under United States Guidelines for Cervical Cancer Screening.

Journal Article J Low Genit Tract Dis · October 2015 OBJECTIVES: To compare the cost-effectiveness of high-risk human papillomavirus (hrHPV) testing using a hrHPV DNA and a hrHPV messenger RNA (mRNA) assay under current US cervical cancer screening guidelines. METHODS: We constructed a Markov model for stoch ... Full text Link to item Cite

Improving NCCN guideline-adherent care for ovarian cancer: Value of an intervention.

Journal Article Gynecol Oncol · September 2015 OBJECTIVE: To estimate the potential cost-effectiveness of an intervention to improve adherence to National Comprehensive Cancer Network (NCCN) guideline-based care for ovarian cancer. METHODS: A modified Markov model with a 5-year time horizon estimated t ... Full text Link to item Cite

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.

Journal Article Nat Commun · August 18, 2015 Polycystic ovary syndrome (PCOS) is a common, highly heritable complex disorder of unknown aetiology characterized by hyperandrogenism, chronic anovulation and defects in glucose homeostasis. Increased luteinizing hormone relative to follicle-stimulating h ... Full text Link to item Cite

Impact of coverage-dependent marginal costs on optimal HPV vaccination strategies.

Journal Article Epidemics · June 2015 The effectiveness of vaccinating males against the human papillomavirus (HPV) remains a controversial subject. Many existing studies conclude that increasing female coverage is more effective than diverting resources into male vaccination. Recently, severa ... Full text Open Access Link to item Cite

Vaginal native tissue repair versus transvaginal mesh repair for apical prolapse: how utilizing different methods of analysis affects the estimated trade-off between reoperation for mesh exposure/erosion and reoperation for recurrent prolapse.

Journal Article Int Urogynecol J · May 2015 INTRODUCTION AND HYPOTHESIS: Informed decision-making about optimal surgical repair of apical prolapse with vaginal native tissue (NT) versus transvaginal mesh (TVM) requires understanding the balance between the potential "harm" of mesh-related complicati ... Full text Link to item Cite

Costs, effectiveness, and workload impact of management strategies for women with an adnexal mass

Journal Article Obstetrical and Gynecological Survey · April 22, 2015 Full text Cite

HPV clearance and the neglected role of stochasticity.

Journal Article PLoS Comput Biol · March 2015 Clearance of anogenital and oropharyngeal HPV infections is attributed primarily to a successful adaptive immune response. To date, little attention has been paid to the potential role of stochastic cell dynamics in the time it takes to clear an HPV infect ... Full text Open Access Link to item Cite

A cost-utility analysis of NRG Oncology/Gynecologic Oncology Group Protocol 218: incorporating prospectively collected quality-of-life scores in an economic model of treatment of ovarian cancer.

Journal Article Gynecol Oncol · February 2015 OBJECTIVE: To estimate quality-of-life (QOL)-adjusted cost-utility with addition of bevacizumab (B) to intravenous paclitaxel/carboplatin (PC) for primary treatment of advanced-stage epithelial ovarian cancer. METHODS: A modified Markov state transition mo ... Full text Link to item Cite

Simulation of labor: A study of the relationship between cesarean section rates and the time spent in labor

Conference Proceedings - Winter Simulation Conference · January 23, 2015 Cesarean delivery is the most common major abdominal surgery in many parts of the world. As of October 2012, the cesarean section rate in the United States was reported to be 32.8% in 2011, rising from 4.5% in 1970. Cesarean sections are associated with an ... Full text Cite

Costs, effectiveness, and workload impact of management strategies for women with an adnexal mass.

Journal Article J Natl Cancer Inst · January 2015 BACKGROUND: We compared the estimated clinical outcomes, costs, and physician workload resulting from available strategies for deciding which women with an adnexal mass should be referred to a gynecologic oncologist. METHODS: We used a microsimulation mode ... Full text Link to item Cite

Pregnancy after treatment for cervical cancer precursor lesions in a retrospective matched cohort.

Journal Article PLoS One · 2015 OBJECTIVE: To determine whether treatments for precancerous cervical lesions were associated with lower pregnancy rates compared to rates in unexposed women and women who had a diagnostic cervical biopsy or colposcopy. DESIGN: Matched, retrospective cohort ... Full text Link to item Cite

Smoking in infertile women with polycystic ovary syndrome: baseline validation of self-report and effects on phenotype.

Journal Article Hum Reprod · December 2014 STUDY QUESTION: Do women with polycystic ovary syndrome (PCOS) seeking fertility treatment report smoking accurately and does participation in infertility treatment alter smoking? SUMMARY ANSWER: Self-report of smoking in infertile women with PCOS is accur ... Full text Link to item Cite

Factors associated with the change in prevalence of cardiomyopathy at delivery in the period 2000-2009: a population-based prevalence study.

Journal Article BJOG · October 2014 OBJECTIVE: Cardiomyopathy (CM) at delivery is increasing in prevalance. The objective of this study was to determine which medical conditions are attributable to this increasing prevalance. DESIGN: Population prevalence study from 2000 to 2009. SETTING: Th ... Full text Link to item Cite

Attribution of 12 high-risk human papillomavirus genotypes to infection and cervical disease.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2014 BACKGROUND: We estimated the prevalence and incidence of 14 human papillomavirus (HPV) types (6/11/16/18/31/33/35/39/45/51/52/56/58/59) in cervicovaginal swabs, and the attribution of these HPV types in cervical intraepithelial neoplasia (CIN), and adenoca ... Full text Link to item Cite

Impact of the National Breast and Cervical Cancer Early Detection Program on cervical cancer mortality among uninsured low-income women in the U.S., 1991-2007.

Journal Article Am J Prev Med · September 2014 BACKGROUND: The benefits of the National Breast and Cervical Cancer Early Detection Program (NBCCEDP) on cervical cancer screening for participating uninsured low-income women have never been measured. PURPOSE: To estimate the benefits in life-years (LYs) ... Full text Link to item Cite

Prioritization of patient-centered comparative effectiveness research for osteoarthritis.

Journal Article Ann Intern Med · June 17, 2014 Osteoarthritis is a leading cause of disability in the United States. This article describes a prioritized research agenda about osteoarthritis management developed for the Patient-Centered Outcomes Research Institute. Evidence gaps were identified by revi ... Full text Link to item Cite

Impact of a routine, opt-out HIV testing program on HIV testing and case detection in North Carolina sexually transmitted disease clinics.

Journal Article Sex Transm Dis · June 2014 BACKGROUND: The impact of routine, opt-out HIV testing programs in clinical settings is inconclusive. The objective of this study was to estimate the impact of an expanded, routine HIV testing program in North Carolina sexually transmitted disease (STD) cl ... Full text Link to item Cite

Prioritization of research addressing management strategies for ductal carcinoma in situ.

Journal Article Ann Intern Med · April 1, 2014 Ductal carcinoma in situ is a common finding in women having mammography screening, and there is considerable uncertainty about the balance of harms and benefits of different management options. This article outlines the process for developing a prioritize ... Full text Link to item Cite

Prioritization of research addressing antipsychotics for adolescents and young adults with bipolar disorder.

Journal Article Ann Intern Med · April 1, 2014 Despite a paucity of high-quality evidence about benefits and harms, antipsychotic medication use among adolescents and young adults with bipolar disorder is increasing. The Patient-Centered Outcomes Research Institute tasked the Duke Evidence Synthesis Gr ... Full text Link to item Cite

Oral contraceptive use and risk of cancer--response.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2014 Full text Link to item Cite

Oral contraceptives and risk of ovarian cancer and breast cancer among high-risk women: a systematic review and meta-analysis.

Journal Article J Clin Oncol · November 20, 2013 PURPOSE: To estimate the risks of ovarian cancer and breast cancer associated with oral contraceptive (OC) use among women at elevated risk owing to mutations in BRCA1/2 or a strong family history. METHODS: We searched PubMed, Embase, the Cochrane Database ... Full text Link to item Cite

Oral contraceptive use and risk of breast, cervical, colorectal, and endometrial cancers: a systematic review.

Journal Article Cancer Epidemiol Biomarkers Prev · November 2013 Oral contraceptives may influence the risk of certain cancers. As part of the AHRQ Evidence Report, Oral Contraceptive Use for the Primary Prevention of Ovarian Cancer, we conducted a systematic review to estimate associations between oral contraceptive us ... Full text Link to item Cite

In reply.

Journal Article Obstet Gynecol · November 2013 Full text Link to item Cite

Cost effectiveness of alternative strategies for incorporating bevacizumab into the primary treatment of ovarian cancer.

Journal Article Cancer · October 15, 2013 BACKGROUND: The objective of this study was to evaluate the comparative effectiveness of strategies that incorporated bevacizumab into the primary platinum-based treatment of ovarian cancer: 1) no bevacizumab; 2) concurrent and maintenance bevacizumab for ... Full text Link to item Cite

How much is another randomized trial of lymph node dissection in endometrial cancer worth? A value of information analysis.

Journal Article Gynecol Oncol · October 2013 OBJECTIVE: This study aimed to assess the value of a randomized controlled trial (RCT) of lymph node dissection (LND) at the time of hysterectomy for high-risk subsets of women with endometrial cancer. METHODS: A modified Markov decision model compared rou ... Full text Link to item Cite

Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis.

Journal Article Obstet Gynecol · August 2013 OBJECTIVE: To estimate the risk of venous thromboembolism, stroke, or myocardial infarction (MI) associated with the use of oral contraceptive pills (OCPs) and to describe how these risks vary by dose or formulation. DATA SOURCES: We searched PubMed, Embas ... Full text Link to item Cite

Oral contraceptive pills as primary prevention for ovarian cancer: a systematic review and meta-analysis.

Journal Article Obstet Gynecol · July 2013 OBJECTIVE: To estimate the overall reduction in ovarian cancer risk associated with the use of oral contraceptive pills (OCPs) and whether reduction in risk is affected by specifics of OCP use, such as formulation or duration of use. DATA SOURCES: We searc ... Full text Link to item Cite

Preference-based utility scores for adverse events associated with the treatment of gynecologic cancers.

Journal Article Int J Gynecol Cancer · July 2013 OBJECTIVE: Our goals were to (1) define a set of descriptive health states related to adverse events (AEs) associated with gynecologic cancer treatment with radical surgery and chemoradiation and (2) derive a set of quality of life-related utility scores c ... Full text Link to item Cite

Age-specific occurrence of HPV16- and HPV18-related cervical cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2013 The age-specific occurrence of cervical cancer related to human papillomavirus (HPV) genotypes HPV16 and HPV18, the two targeted by current HPV vaccines, is not well described. We therefore used data from two large, tissue-based HPV genotyping studies of c ... Full text Link to item Cite

Oral contraceptive use for the primary prevention of ovarian cancer.

Journal Article Evid Rep Technol Assess (Full Rep) · June 2013 OBJECTIVE: To estimate the overall balance of harms and benefits from the potential use of oral contraceptives (OCs) for the primary prevention of ovarian cancer DATA SOURCES: We searched PubMed®, Embase®, the Cochrane Database of Systematic Reviews, and C ... Link to item Cite

Perinatal implications of motor vehicle accident trauma during pregnancy: identifying populations at risk.

Journal Article Am J Obstet Gynecol · June 2013 OBJECTIVE: The purpose of this study was to examine the association between restraint use, race, and perinatal outcome after motor vehicle accidents (MVAs) during pregnancy. STUDY DESIGN: The Duke Trauma Registry and medical records were searched for infor ... Full text Link to item Cite

Cost-effectiveness of BRCA1 and BRCA2 mutation testing to target PARP inhibitor use in platinum-sensitive recurrent ovarian cancer.

Journal Article Int J Gynecol Cancer · June 2013 OBJECTIVES: (1) To determine whether use of a PARP inhibitor or (2) BRCA1/2 mutation testing followed by a PARP inhibitor for test positives is potentially cost-effective for maintenance treatment of platinum-sensitive recurrent high-grade serous ovarian c ... Full text Link to item Cite

How Obamacare will impact reproductive health.

Journal Article Semin Reprod Med · May 2013 For many years, health care delivery in the United States was accomplished through a complicated and evolving series of publicly and privately available insurance programs. In recent years, the increasing cost of health care as well as the relatively large ... Full text Link to item Cite

Screening for cervical cancer: a modeling study for the US Preventive Services Task Force.

Journal Article J Low Genit Tract Dis · April 2013 OBJECTIVE: This study addresses the following 3 questions posed by the US Preventive Services Task Force: (1) at what age should screening for cervical cancer begin; (2) at what age should screening for cervical cancer end; and (3) how do the benefits and ... Full text Link to item Cite

Comparison of characteristics of fibroids in African American and white women undergoing premenopausal hysterectomy.

Journal Article Fertil Steril · March 1, 2013 OBJECTIVE: To compare pathologic characteristics and epidemiologic risk factors for uterine fibroids in African American and white women undergoing hysterectomy. DESIGN: Cross-sectional analysis of women undergoing premenopausal hysterectomy. SETTING: Two ... Full text Link to item Cite

Clinical trial experience with prophylactic human papillomavirus 6/11/16/18 vaccine in young black women.

Journal Article J Adolesc Health · March 2013 PURPOSE: Human papillomavirus (HPV) is the causative agent of cervical cancer. Black women are disproportionally diagnosed and have higher mortality from cervical cancer in the United States. Here we describe the prophylactic efficacy and safety of a quadr ... Full text Link to item Cite

Computer modeling informs study design: vaginal estrogen to prevent mesh erosion after different routes of prolapse surgery.

Journal Article Int Urogynecol J · March 2013 INTRODUCTION AND HYPOTHESIS: Many clinicians use perioperative vaginal estrogen therapy (estradiol, E(2)) to diminish the risk of mesh erosion after prolapse surgery, though supporting evidence is limited. We assessed the feasibility of a factorial randomi ... Full text Link to item Cite

Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis.

Journal Article Obstetrics and gynecology · January 1, 2013 To estimate the risk of venous thromboembolism, stroke, or myocardial infarction (MI) associated with the use of oral contraceptive pills (OCPs) and to describe how these risks vary by dose or formulation. We searched PubMed, Embase, the Cochrane Database ... Cite

A branching process model of ovarian cancer.

Journal Article J Theor Biol · December 7, 2012 Ovarian cancer is usually diagnosed at an advanced stage, rendering the possibility of cure unlikely. To date, no cost-effective screening test has proven effective for reducing mortality. To estimate the window of opportunity for ovarian cancer screening, ... Full text Link to item Cite

Age trends in the prevalence of cervical squamous intraepithelial lesions among HIV-positive women in Cameroon: a cross-sectional study.

Journal Article BMC Res Notes · October 29, 2012 BACKGROUND: Cervical squamous intra-epithelial lesions (SIL) are more frequent in HIV-positive women overall. However the appropriate age at which to begin and end cervical cancer screening for early detection of lesions in HIV-positive women is not clear. ... Full text Link to item Cite

The Authors’ Reply

Journal Article American Journal of Clinical Pathology · October 1, 2012 Full text Cite

In reply

Journal Article Journal of Lower Genital Tract Disease · October 1, 2012 Full text Cite

Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome

Journal Article Obstetrical and Gynecological Survey · September 1, 2012 Full text Cite

American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer.

Journal Article J Low Genit Tract Dis · July 2012 An update to the American Cancer Society (ACS) guideline regarding screening for the early detection of cervical precancerous lesions and cancer is presented. The guidelines are based on a systematic evidence review, contributions from six working groups, ... Full text Link to item Cite

High prevalence of cervical squamous intraepithelial lesions in women on antiretroviral therapy in Cameroon: Is targeted screening feasible?

Journal Article Cancer Epidemiol · June 2012 BACKGROUND: Cervical cancer is the most common cancer in women in low-income countries. Although cervical cancer incidence and mortality is higher in HIV-positive women, resource limitations restrict the implementation of systematic screening programs in t ... Full text Link to item Cite

Altering hirsutism through ovulation induction in women with polycystic ovary syndrome.

Journal Article Obstet Gynecol · June 2012 OBJECTIVE: Many women with polycystic ovary syndrome (PCOS) experience infertility and hirsutism and often seek treatment for both concurrently. We investigated whether women who ovulate in response to treatment with clomiphene citrate, metformin, or both ... Full text Link to item Cite

Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treatment of ischemic heart disease: Future research needs prioritization.

Journal Article Am Heart J · May 2012 BACKGROUND: A recent review evaluated the comparative effectiveness of angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin II receptor blockers (ARBs) in patients with or at high risk for stable ischemic heart disease (IHD). The prioritizatio ... Full text Link to item Cite

Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome.

Journal Article Obstet Gynecol · May 2012 OBJECTIVE: To estimate whether progestin-induced endometrial shedding, before ovulation induction with clomiphene citrate, metformin, or a combination of both, affects ovulation, conception, and live birth rates in women with polycystic ovary syndrome (PCO ... Full text Link to item Cite

American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer.

Journal Article Am J Clin Pathol · April 2012 An update to the American Cancer Society (ACS) guideline regarding screening for the early detection of cervical precancerous lesions and cancer is presented. The guidelines are based on a systematic evidence review, contributions from 6 working groups, an ... Full text Link to item Cite

High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples.

Journal Article Hum Reprod · March 2012 BACKGROUND: Although histological dating of endometrial biopsies provides little help for prediction or diagnosis of infertility, analysis of individual endometrial proteins, proteomic profiling and transcriptome analysis have suggested several biomarkers ... Full text Link to item Cite

Cost-effectiveness of combination versus sequential docetaxel and carboplatin for the treatment of platinum-sensitive, recurrent ovarian cancer.

Journal Article Cancer · January 15, 2012 BACKGROUND: In a randomized controlled trial (RCT) of patients with recurrent, platinum-sensitive ovarian cancer, the combination weekly docetaxel and carboplatin was associated a with progression-free survival (PFS) of 13.7 months compared with 8.4 months ... Full text Link to item Cite

American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer.

Journal Article CA Cancer J Clin · 2012 An update to the American Cancer Society (ACS) guideline regarding screening for the early detection of cervical precancerous lesions and cancer is presented. The guidelines are based on a systematic evidence review, contributions from 6 working groups, an ... Full text Link to item Cite

Effect of hysterectomy with ovarian preservation on ovarian function.

Journal Article Obstet Gynecol · December 2011 OBJECTIVE: To prospectively estimate the risk for earlier ovarian failure among women undergoing hysterectomy with ovarian preservation, as compared with women of similar age without hysterectomy. METHODS: A prospective cohort study was conducted among wom ... Full text Link to item Cite

Preoperative screening strategies for bacterial vaginosis prior to elective hysterectomy: a cost comparison study.

Journal Article Am J Obstet Gynecol · November 2011 OBJECTIVE: The purpose of this study is to compare costs of 3 strategies for women undergoing hysterectomy: (1) test all patients for bacterial vaginosis; treat if positive; (2) treat all patients for bacterial vaginosis; (3) neither test nor treat patient ... Full text Link to item Cite

Leiomyoma-related hospitalization and surgery: prevalence and predicted growth based on population trends.

Journal Article Am J Obstet Gynecol · November 2011 OBJECTIVE: To estimate leiomyoma-related inpatient care in the United States for 2007 with predictions for the ensuing 40 years. STUDY DESIGN: We used the 2007 Nationwide Inpatient Sample to estimate hospitalizations and inpatient surgeries for uterine lei ... Full text Link to item Cite

Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome.

Journal Article J Clin Endocrinol Metab · October 2011 CONTEXT: Nonalcoholic fatty liver disease is common to insulin-resistant states such as polycystic ovary syndrome (PCOS). Metformin (MET) is often used to treat PCOS but information is limited as to its effects on liver function. OBJECTIVE: We sought to de ... Full text Link to item Cite

Cost comparison of strategies for the management of venous thromboembolic event risk following laparotomy for ovarian cancer.

Journal Article Gynecol Oncol · September 2011 OBJECTIVE: To evaluate the costs and effectiveness of thromboprophylaxis strategies following laparotomy for ovarian cancer. METHODS: We constructed a decision model to evaluate six strategies for management of postoperative venous thromboembolism (VTE) ri ... Full text Link to item Cite

Predicting the number of women who will undergo incontinence and prolapse surgery, 2010 to 2050.

Journal Article Am J Obstet Gynecol · September 2011 OBJECTIVE: We sought to estimate the number of women who will undergo inpatient and outpatient surgery for stress urinary incontinence (SUI) or pelvic organ prolapse (POP) in the United States from 2010 through 2050. STUDY DESIGN: Using the 2007 Nationwide ... Full text Link to item Cite

Reported symptoms before and one year after hysterectomy in African American and white women.

Journal Article J Womens Health (Larchmt) · July 2011 PURPOSE: Although African American women are more likely than white women to undergo hysterectomy, there are few data describing their symptoms before and after surgery. This report compares reported symptoms in white and African American women before and ... Full text Link to item Cite

End-of-study safety, immunogenicity, and efficacy of quadrivalent HPV (types 6, 11, 16, 18) recombinant vaccine in adult women 24-45 years of age.

Journal Article Br J Cancer · June 28, 2011 BACKGROUND: Previous analyses from a randomised trial in women aged 24-45 years have shown the quadrivalent human papillomavirus (qHPV) vaccine to be efficacious in the prevention of infection, cervical intraepithelial neoplasia (CIN), and external genital ... Full text Link to item Cite

Utility scores and treatment preferences for clinical early-stage cervical cancer.

Journal Article Value Health · June 2011 OBJECTIVES: To determine utility scores for health states relevant to the treatment of early-stage, high-risk cervical cancer. METHODS: Seven descriptive health states incorporating the physical and emotional aspects of medical treatment, recovery, and pro ... Full text Link to item Cite

Influence of timing of seasonal influenza vaccination on effectiveness and cost-effectiveness in pregnancy.

Journal Article Am J Obstet Gynecol · June 2011 The purpose of this review was to estimate the impact of timing of seasonal influenza vaccination during pregnancy on health and economic outcomes. Cost-effectiveness analysis with a dynamic model of the US population of pregnant women and infants who were ... Full text Link to item Cite

Potential impact of antiretroviral therapy and screening on cervical cancer mortality in HIV-positive women in sub-Saharan Africa: a simulation.

Journal Article PLoS One · April 4, 2011 BACKGROUND: Despite having high cervical cancer incidence and mortality rates, screening for cervical precancerous lesions remains infrequent in sub-Saharan Africa. The need to screen HIV-positive women because of the higher prevalence and faster progressi ... Full text Link to item Cite

Development of an ovarian cancer screening decision model that incorporates disease heterogeneity: implications for potential mortality reduction.

Journal Article Cancer · February 1, 2011 BACKGROUND: Pathologic and genetic data suggest that epithelial ovarian cancer may consist of indolent and aggressive phenotypes. The objective of the current study was to estimate the impact of a 2-phenotype paradigm of epithelial ovarian cancer on the mo ... Full text Link to item Cite

Smoking prevalence in early pregnancy: comparison of self-report and anonymous urine cotinine testing.

Journal Article J Matern Fetal Neonatal Med · January 2011 OBJECTIVE: Societal pressures against smoking during pregnancy may lead to a reduction in disclosure of smoking status. The objective of this study was to compare prevalence of smoking at prenatal intake by self-report with anonymous biochemical validation ... Full text Link to item Cite

Adverse birth outcomes among nulliparous vs. multiparous women.

Journal Article Public Health Rep · 2011 OBJECTIVES: Previous studies indicate that nulliparous women (i.e., women having no previous births) are at higher risk for adverse birth outcomes than multiparous women (i.e., women having had at least one previous birth). We examined whether part of the ... Full text Link to item Cite

Projecting the need for gynecologic oncologists for the next 40 years.

Journal Article Obstet Gynecol · December 2010 OBJECTIVE: To estimate the ratio of gynecologic cancer cases to practicing gynecologic oncologists in the United States over the next 40 years. METHODS: Using population projections from the U.S. Census Bureau and incidence and mortality rates from Surveil ... Full text Link to item Cite

Total testosterone assays in women with polycystic ovary syndrome: precision and correlation with hirsutism.

Journal Article J Clin Endocrinol Metab · December 2010 CONTEXT: There is no standardized assay of testosterone in women. Liquid chromatography mass spectrometry (LC/MS) has been proposed as the preferable assay by an Endocrine Society Position Statement. OBJECTIVE: The aim was to compare assay results from a d ... Full text Link to item Cite

Intercourse compliance, ovulation, and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial.

Journal Article Fertil Steril · September 2010 OBJECTIVE: To investigate the relationship among intercourse compliance, ovulation, and the occurrence of pregnancy in the Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (RMNPPCOS) Trial. DESIGN: Post hoc data analysis of subjects i ... Full text Link to item Cite

Body mass index and intercourse compliance.

Journal Article Fertil Steril · September 2010 OBJECTIVE: To investigate the relationship between body mass index and intercourse compliance in the Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (RMN PPCOS) Trial. DESIGN: Post hoc data analysis of subjects in the RMN PPCOS Trial ... Full text Link to item Cite

Cost comparison among robotic, laparoscopic, and open hysterectomy for endometrial cancer.

Journal Article Obstet Gynecol · September 2010 OBJECTIVE: To use decision modeling to compare the costs associated with robotic, laparoscopic, and open hysterectomy for the treatment of endometrial cancer. METHODS: Three separate models were used, each with sensitivity analysis: 1) a societal perspecti ... Full text Link to item Cite

Impact of a chemoresponse assay on treatment costs for recurrent ovarian cancer.

Journal Article Am J Obstet Gynecol · August 2010 OBJECTIVE: We sought to estimate mean costs of chemotherapy treatment for recurrent ovarian cancer with or without use of a chemoresponse assay. STUDY DESIGN: We estimated mean costs for 3 groups: (1) assay assisted: 75 women who received oncologist's choi ... Full text Link to item Cite

Four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trial.

Journal Article BMJ · July 20, 2010 OBJECTIVES: To evaluate the prophylactic efficacy of the human papillomavirus (HPV) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata). DESIGN: Data from two inte ... Full text Link to item Cite

Optimal timing of implantable cardioverter-defibrillator implantation after myocardial infarction: a decision analysis.

Journal Article J Cardiovasc Electrophysiol · July 2010 BACKGROUND: The optimal timing of implantable cardioverter defibrillator (ICD) placement for the primary prevention of sudden cardiac death after myocardial infarction (MI) remains unknown. METHODS AND RESULTS: We developed a Markov model to investigate th ... Full text Link to item Cite

Accuracy and cost-effectiveness of cervical cancer screening by high-risk human papillomavirus DNA testing of self-collected vaginal samples.

Journal Article J Low Genit Tract Dis · July 2010 OBJECTIVE: Estimate the accuracy and cost-effectiveness of cervical cancer screening strategies based on high-risk human papillomavirus (HPV) DNA testing of self-collected vaginal samples. MATERIALS AND METHODS: A subset of 1,665 women (age range, 18-50 y) ... Full text Link to item Cite

Impact of human papillomavirus (HPV)-6/11/16/18 vaccine on all HPV-associated genital diseases in young women.

Journal Article J Natl Cancer Inst · March 3, 2010 BACKGROUND: The impact of the prophylactic vaccine against human papillomavirus (HPV) types 6, 11, 16, and 18 (HPV6/11/16/18) on all HPV-associated genital disease was investigated in a population that approximates sexually naive women in that they were "n ... Full text Link to item Cite

Fertility patients' views about frozen embryo disposition: results of a multi-institutional U.S. survey.

Journal Article Fertil Steril · February 2010 OBJECTIVE: To describe fertility patients' preferences for disposition of cryopreserved embryos and determine factors important to these preferences. DESIGN: Cross-sectional survey conducted between June 2006 and July 2007. SETTING: Nine geographically div ... Full text Link to item Cite

Predictors of pregnancy in women with polycystic ovary syndrome

Journal Article Obstetrical and Gynecological Survey · January 1, 2010 Full text Cite

Cost-effectiveness of sacral neuromodulation versus intravesical botulinum A toxin for treatment of refractory urge incontinence.

Journal Article J Urol · December 2009 PURPOSE: We determined the cost-effectiveness of sacral neuromodulation vs intravesical botulinum toxin A for the treatment of refractory urge incontinence. MATERIALS AND METHODS: We developed a Markov decision model using a societal perspective to compare ... Full text Link to item Cite

Forecasting the prevalence of pelvic floor disorders in U.S. Women: 2010 to 2050.

Journal Article Obstet Gynecol · December 2009 OBJECTIVES: To estimate the number of women who will have symptomatic pelvic floor disorders in the United States from 2010 to 2050. METHODS: We used population projections from the U.S. Census Bureau from 2010 to 2050 and published age-specific prevalence ... Full text Link to item Cite

Human papillomavirus testing with Pap triage for cervical cancer prevention in Canada: a cost-effectiveness analysis.

Journal Article BMC Med · November 9, 2009 BACKGROUND: Recently published results from a large randomized trial (Canadian Cervical Cancer Screening Trial study group) suggest that human papillomavirus testing followed by Pap smear-based triage for human papillomavirus positive women may be an effec ... Full text Link to item Cite

A pooled analysis of continued prophylactic efficacy of quadrivalent human papillomavirus (Types 6/11/16/18) vaccine against high-grade cervical and external genital lesions.

Journal Article Cancer Prev Res (Phila) · October 2009 Quadrivalent human papillomavirus (HPV) vaccine has been shown to provide protection from HPV 6/11/16/18-related cervical, vaginal, and vulvar disease through 3 years. We provide an update on the efficacy of the quadrivalent HPV vaccine against high-grade ... Full text Link to item Cite

Evaluation of quadrivalent HPV 6/11/16/18 vaccine efficacy against cervical and anogenital disease in subjects with serological evidence of prior vaccine type HPV infection.

Journal Article Hum Vaccin · October 2009 OBJECTIVE: In the quadrivalent (types 6/11/16/18) HPV vaccine (GARDASIL/SILGARD) clinical program, 73% of women aged 16-26 were naïve to all vaccine HPV types. In these women, prophylactic administration of the vaccine was highly effective in preventing HP ... Full text Link to item Cite

Predictors of adverse events among pregnant smokers exposed in a nicotine replacement therapy trial.

Journal Article Am J Obstet Gynecol · October 2009 OBJECTIVE: The purpose of this study was to determine the contribution of randomization to nicotine replacement therapy (NRT), sociodemographic and psychosocial factors, and pregnancy and medical history to serious perinatal adverse events among pregnant s ... Full text Link to item Cite

Predictors of pregnancy in women with polycystic ovary syndrome.

Journal Article J Clin Endocrinol Metab · September 2009 CONTEXT: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. The selection of first-line therapies for ovulation induction is empiric. OBJECTIVE: The aim of the study was to develop a clinically useful predictive model of ... Full text Link to item Cite

The impact of human papillomavirus vaccination on cervical cancer prevention efforts.

Journal Article Gynecol Oncol · August 2009 OBJECTIVES: To review concepts, information, obstacles, and approaches to cervical cancer screening and prevention as vaccination against human papillomavirus (HPV) types 16 and 18 is adopted. METHODS: Expert forum, conducted September 12-13, 2008, hosted ... Full text Link to item Cite

Complications of hysterectomy in women with von Willebrand disease.

Journal Article Haemophilia · July 2009 Case reports and small case series suggest that women with von Willebrand disease (VWD) are at a very high risk of bleeding complications with hysterectomy. As the procedure may be beneficial to women who suffer from heavy menstrual bleeding and have compl ... Full text Link to item Cite

Safety, immunogenicity, and efficacy of quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine in women aged 24-45 years: a randomised, double-blind trial.

Journal Article Lancet · June 6, 2009 BACKGROUND: Although the peak incidence of human papillomavirus (HPV) infection occurs in most populations within 5-10 years of first sexual experience, all women remain at risk for acquisition of HPV infections. We tested the safety, immunogenicity, and e ... Full text Link to item Cite

Cost-effectiveness analysis of annual screening strategies for endometrial cancer.

Journal Article Am J Obstet Gynecol · June 2009 OBJECTIVE: The objective of the study was to determine the cost-effectiveness of annual screening tests for endometrial cancer. STUDY DESIGN: Markov state transition model of the natural history of endometrial cancer used as the design for the study. Incid ... Full text Link to item Cite

Determination of quality of life-related utilities for health states relevant to ovarian cancer diagnosis and treatment.

Journal Article Gynecol Oncol · May 2009 OBJECTIVES: (1) To define a set of health state descriptions related to screening, diagnosis, prognosis, and toxicities relevant to ovarian cancer; (2) To derive a set of quality of life-related utilities to be used for cost-effectiveness analyses. METHODS ... Full text Link to item Cite

Adherence to nicotine replacement therapy among pregnant smokers.

Journal Article Nicotine Tob Res · May 2009 INTRODUCTION: This secondary analysis examined the association between adherence to nicotine replacement therapy (NRT) and smoking cessation among pregnant smokers enrolled in Baby Steps, an open-label randomized controlled trial testing cognitive-behavior ... Full text Link to item Cite

A prospective study of weight gain after premenopausal hysterectomy.

Journal Article J Womens Health (Larchmt) · May 2009 PURPOSE: Many women who have had hysterectomies have the perception that they gained weight after surgery that cannot be attributed to changes in diet or physical activity. The purpose of this analysis was to assess weight gain in premenopausal women in th ... Full text Link to item Cite

Cost-effectiveness of botulinum toxin a versus anticholinergic medications for idiopathic urge incontinence.

Journal Article J Urol · May 2009 PURPOSE: We assessed the cost-effectiveness of botulinum toxin A injection compared to anticholinergic medications for the treatment of idiopathic urge incontinence. MATERIALS AND METHODS: A Markov decision analysis model was developed to compare the costs ... Full text Link to item Cite

The impact of quadrivalent human papillomavirus (HPV; types 6, 11, 16, and 18) L1 virus-like particle vaccine on infection and disease due to oncogenic nonvaccine HPV types in generally HPV-naive women aged 16-26 years.

Journal Article J Infect Dis · April 1, 2009 BACKGROUND: Human papillomavirus (HPV)-6/11/16/18 vaccine reduces the risk of HPV-6/11/16/18-related cervical intraepithelial neoplasia (CIN) 1-3 or adenocarcinoma in situ (AIS). Here, its impact on CIN1-3/AIS associated with nonvaccine oncogenic HPV types ... Full text Link to item Cite

The impact of quadrivalent human papillomavirus (HPV; types 6, 11, 16, and 18) L1 virus-like particle vaccine on infection and disease due to oncogenic nonvaccine HPV types in sexually active women aged 16-26 years.

Journal Article J Infect Dis · April 1, 2009 BACKGROUND: We evaluated the impact of a quadrivalent human papillomavirus (HPV) vaccine on infection and cervical disease related to 10 nonvaccine HPV types (31, 33, 35, 39, 45, 51, 52, 56, 58, and 59) associated with >20% of cervical cancers. The populat ... Full text Link to item Cite

Cost effectiveness of a test to detect metastases for endometrial cancer.

Journal Article Gynecol Oncol · March 2009 OBJECTIVE: To estimate the potential cost-effectiveness of a hypothetical test to screen for lymph node metastases in women with newly diagnosed, apparent early stage endometrial cancer. METHODS: A decision model was constructed to inform a choice between ... Full text Link to item Cite

HPV antibody levels and clinical efficacy following administration of a prophylactic quadrivalent HPV vaccine.

Journal Article Vaccine · December 9, 2008 The efficacy of the quadrivalent Human Papillomavirus (HPV) vaccine is thought to be mediated by humoral immunity. We evaluated the correlation between quadrivalent HPV vaccine-induced serum anti-HPV responses and efficacy. 17,622 women were vaccinated at ... Full text Link to item Cite

Reductions in human papillomavirus-disease resource use and costs with quadrivalent human papillomavirus (types 6, 11, 16, and 18) recombinant vaccination: the FUTURE Study Economic Evaluation.

Journal Article Value Health · December 2008 OBJECTIVE: To examine the short-term impact of quadrivalent human papillomavirus (HPV) (types 6/11/16/18) recombinant vaccination upon HPV disease-related health-care resource utilization and costs among young women. METHODS: We analyzed data from a random ... Full text Link to item Cite

Reducing ovarian cancer mortality through screening: Is it possible, and can we afford it?

Journal Article Gynecol Oncol · November 2008 OBJECTIVE: Ovarian cancer is a leading cause of cancer-related deaths among women. Given the low prevalence of this disease, the effectiveness of screening strategies has not been established. We wished to estimate the clinical impact and cost-effectivenes ... Full text Link to item Cite

Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial.

Journal Article Fertil Steril · October 2008 We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphe ... Full text Link to item Cite

Descriptive evidence that risk profiles for cervical intraepithelial neoplasia 1, 2, and 3 are unique.

Journal Article Cancer Epidemiol Biomarkers Prev · September 2008 OBJECTIVE: This study aimed to estimate if risk factor profiles for histologically confirmed cervical intraepithelial neoplasia (CIN) 2 lesions differ from those for CIN 1 or 3. METHODS: A total of 2,055 women positive for high-risk human papillomavirus, w ... Full text Link to item Cite

Extended-release metformin does not reduce the clomiphene citrate dose required to induce ovulation in polycystic ovary syndrome.

Journal Article J Clin Endocrinol Metab · August 2008 CONTEXT: When used for ovulation induction, higher doses of clomiphene may lead to antiestrogenic side effects that reduce fecundity. It has been suggested that metformin in combination with clomiphene can restore ovulation to some clomiphene-resistant ano ... Full text Link to item Cite

A national study of the complications of lupus in pregnancy.

Journal Article Am J Obstet Gynecol · August 2008 OBJECTIVE: This study was undertaken to determine the risk of rare complications during pregnancy for women with systemic lupus erythematosus. STUDY DESIGN: By using the Nationwide Inpatient Sample from 2000-2003, we compared maternal and pregnancy complic ... Full text Link to item Cite

Baseline demographic characteristics of subjects enrolled in international quadrivalent HPV (types 6/11/16/18) vaccine clinical trials.

Journal Article Curr Med Res Opin · June 2008 BACKGROUND: In Phase II/III trials, administration of quadrivalent human papillomavirus (HPV) (types 6/11/16/18) L1 virus-like-particle vaccine was highly effective in preventing HPV6/11/16/18-related cervical intraepithelial neoplasia and non-invasive cer ... Full text Link to item Cite

Weight gain after pre-menopausal hysterectomy

Conference AMERICAN JOURNAL OF EPIDEMIOLOGY · June 1, 2008 Link to item Cite

The current and future role of screening in the era of HPV vaccination.

Journal Article Gynecol Oncol · May 2008 With the introduction of cervical screening programs, the incidence and mortality of cervical cancer has been drastically reduced. Techniques such as the traditional Papanicolaou test and the newer liquid-based cytology allow for the early detection of cer ... Full text Link to item Cite

Effectiveness of assisted reproductive technology (ART).

Journal Article Evid Rep Technol Assess (Full Rep) · May 2008 OBJECTIVES: We reviewed the evidence regarding the outcomes of interventions used in ovulation induction, superovulation, and in vitro fertilization (IVF) for the treatment of infertility. Short-term outcomes included pregnancy, live birth, multiple gestat ... Link to item Cite

Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene.

Journal Article J Clin Endocrinol Metab · March 2008 CONTEXT: Clomiphene and insulin sensitizers such as metformin are used to induce ovulation in polycystic ovary syndrome (PCOS), but the ovulatory response is variable, and the causes of this variation are poorly understood. OBJECTIVE: Our objective was to ... Full text Link to item Cite

Adding a quadrivalent human papillomavirus vaccine to the UK cervical cancer screening programme: A cost-effectiveness analysis.

Journal Article Cost Eff Resour Alloc · February 15, 2008 BACKGROUND: We assessed the cost-effectiveness of adding a quadrivalent (6/11/16/18) human papillomavirus (HPV) vaccine to the current screening programme in the UK compared to screening alone. METHODS: A Markov model of the natural history of HPV infectio ... Full text Link to item Cite

Uterine artery embolization for treatment of leiomyomata: long-term outcomes from the FIBROID Registry.

Journal Article Obstet Gynecol · January 2008 OBJECTIVE: To assess long-term clinical outcomes of uterine artery embolization across a wide variety of practice settings in a large patient cohort. METHODS: The Fibroid Registry for Outcomes Data (FIBROID) for Uterine Embolization was a 3-year, single-ar ... Full text Link to item Cite

Primary surgery versus chemoradiation in the treatment of IB2 cervical carcinoma: a cost effectiveness analysis.

Journal Article Gynecol Oncol · December 2007 OBJECTIVES: To estimate the relative cost-effectiveness of treatments for patients with FIGO stage IB2 cervical cancer and no evidence of metastasis as determined by combination of positron emission tomography/computed tomography (PET/CT). METHODS: A Marko ... Full text Link to item Cite

Potential effects of decreased cervical cancer screening participation after HPV vaccination: an example from the U.S.

Journal Article Vaccine · November 23, 2007 A concern with widespread implementation of HPV vaccination programs is that women may mistakenly decide that they do not need to be screened any longer, and thus be less likely to participate in cervical cancer screening, because they view themselves to b ... Full text Link to item Cite

Prophylactic efficacy of a quadrivalent human papillomavirus (HPV) vaccine in women with virological evidence of HPV infection.

Journal Article J Infect Dis · November 15, 2007 BACKGROUND: A quadrivalent (types 6, 11, 16, and 18) human papillomavirus (HPV) L1 virus-like-particle (VLP) vaccine has been shown to be 95%-100% effective in preventing cervical and genital disease related to HPV-6, -11, -16, and -18 in 16-26-year-old wo ... Full text Link to item Cite

Management of platinum-sensitive recurrent ovarian cancer: a cost-effectiveness analysis.

Journal Article Gynecol Oncol · November 2007 OBJECTIVE: We wished to compare the cost-effectiveness of three chemotherapy regimens for treatment of recurrent platinum-sensitive ovarian cancer. METHODS: A Markov decision tree was constructed comparing three chemotherapy regimens: (1) carboplatin alone ... Full text Link to item Cite

Nicotine replacement and behavioral therapy for smoking cessation in pregnancy.

Journal Article Am J Prev Med · October 2007 BACKGROUND: This study examines whether adding nicotine replacement therapy (NRT) to cognitive-behavioral therapy (CBT) for pregnant smokers increases rates of smoking cessation. METHODS: An open-label randomized trial (Baby Steps, n=181) of CBT-only versu ... Full text Link to item Cite

Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions

Journal Article Obstetrical and Gynecological Survey · September 1, 2007 Full text Cite

Cost-effectiveness of treatment strategies for cervical infection among women at high risk in Madagascar.

Journal Article Sex Transm Dis · September 2007 BACKGROUND: According to the national guidelines developed in 2001, a woman at high risk of gonorrhea and chlamydia in Madagascar is treated presumptively at her first sexually transmitted infection clinic visit; risk-based treatment (RB) is subsequently u ... Full text Link to item Cite

A cost-effectiveness analysis of adding a human papillomavirus vaccine to the Australian National Cervical Cancer Screening Program.

Journal Article Sex Health · September 2007 BACKGROUND: The cost-effectiveness of adding a human papillomavirus (HPV) vaccine to the Australian National Cervical Screening Program compared to screening alone was examined. METHODS: A Markov model of the natural history of HPV infection that incorpora ... Full text Link to item Cite

Cost-effectiveness of adjuvant radiotherapy in intermediate risk endometrial cancer.

Journal Article Gynecol Oncol · August 2007 OBJECTIVES: Endometrial cancer is the most common gynecologic malignancy in the United States. Adjuvant radiotherapy in patients with intermediate risk disease (stage IB, IC, and occult stage II) is controversial. Despite no proven survival advantage, a si ... Full text Link to item Cite

Is Burch colposuspension ever cost-effective compared with tension-free vaginal tape for stress incontinence?

Journal Article Am J Obstet Gynecol · July 2007 OBJECTIVE: This study was undertaken to evaluate the cost-effectiveness of Burch colposuspension compared with tension-free vaginal tape. STUDY DESIGN: A Markov decision model was developed to compare costs (2005 US dollars) and effectiveness (quality-adju ... Full text Link to item Cite

The authors reply [5]

Journal Article New England Journal of Medicine · May 10, 2007 Cite

Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions.

Journal Article N Engl J Med · May 10, 2007 BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the preventi ... Full text Link to item Cite

Treatment of infertility in the polycystic ovary syndrome - Reply

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · May 10, 2007 Link to item Cite

Response to Letter to the Editor

Journal Article Contraception · April 1, 2007 Full text Cite

Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.

Journal Article N Engl J Med · February 8, 2007 Featured Publication BACKGROUND: The polycystic ovary syndrome is a common cause of infertility. Clomiphene and insulin sensitizers are used alone and in combination to induce ovulation, but it is unknown whether one approach is superior. METHODS: We randomly assigned 626 infe ... Full text Link to item Cite

Utility of screening for other causes of infertility in women with "known" polycystic ovary syndrome.

Journal Article Fertil Steril · February 2007 Featured Publication We investigated the prevalence of abnormal screening results (questionnaire and testing for other causes of oligo-ovulation, male or tubal factor infertility) in a group of 1,313 oligo-ovulatory women (included and excluded subjects) whose condition was sc ... Full text Link to item Cite

Abnormal outcomes following cervical cancer screening: event duration and health utility loss.

Journal Article Med Decis Making · 2007 BACKGROUND: For decision analytic models, little empirical data are available from which to model the amount of time women spend with various cervical cytologic and histologic diagnoses following an abnormal Pap smear or the associated loss in quality-adju ... Full text Link to item Cite

Health care resource use for uterine fibroid tumors in the United States.

Journal Article Am J Obstet Gynecol · October 2006 Featured Publication OBJECTIVE: The purpose of this study was to quantify the total direct cost to the US health care system for the management of uterine leiomyomas. STUDY DESIGN: We used Center for Disease Control heath care databases for estimates of inpatient care, ambulat ... Full text Link to item Cite

Genomic tests for ovarian cancer detection and management.

Journal Article Evid Rep Technol Assess (Full Rep) · October 2006 OBJECTIVES: To assess the evidence that the use of genomic tests for ovarian cancer screening, diagnosis, and treatment leads to improved outcomes. DATA SOURCES: PubMed and reference lists of recent reviews. REVIEW METHODS: We evaluated tests for: (a) sing ... Link to item Cite

The Pregnancy in Polycystic Ovary Syndrome study: baseline characteristics of the randomized cohort including racial effects.

Journal Article Fertil Steril · October 2006 OBJECTIVE: To report the baseline characteristics and racial differences in the polycystic ovary syndrome (PCOS) phenotype from a large multicenter clinical trial (PPCOS). DESIGN: Double-blind, randomized trial of three treatment regimens (with extended re ... Full text Link to item Cite

O-2

Conference Fertility and Sterility · September 2006 Full text Cite

Chapter 19: Cost-effectiveness of cervical cancer screening.

Journal Article Vaccine · August 31, 2006 In the last two decades, computer-based models of cervical cancer screening have been used to evaluate the cost-effectiveness of different secondary prevention policies. Analyses in countries with existing screening programs have focused on identifying the ... Full text Link to item Cite

Challenges and solutions for recruiting pregnant smokers into a nicotine replacement therapy trial.

Journal Article Nicotine Tob Res · August 2006 Improvements in smoking cessation interventions for pregnant smokers are needed. One major step is to examine the potential effectiveness of nicotine replacement therapy (NRT). The potential benefits of providing pregnant women with NRT to help them quit s ... Full text Link to item Cite

Cost-effectiveness analysis of liquid-based cytology and human papillomavirus testing in cervical cancer screening.

Journal Article Obstet Gynecol · May 2006 Featured Publication OBJECTIVE: To compare the outcomes of several cervix cancer screening strategies in a military population using a model that considers both direct and indirect costs of health care. METHODS: A Markov model of the natural history of cervical cancer was used ... Full text Link to item Cite

Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality.

Journal Article Am J Obstet Gynecol · May 2006 Featured Publication OBJECTIVE: The purpose of this study was to estimate the incidence, risk factors, and mortality from pregnancy-related venous thromboembolism. STUDY DESIGN: The Nationwide Inpatient Sample from the Healthcare Cost and Utilization Project of the Agency for ... Full text Link to item Cite

Acupuncture as adjunctive therapy in assisted reproduction: remaining uncertainties.

Journal Article Fertil Steril · May 2006 Two randomized trials provide suggestive evidence that acupuncture might be an effective adjunctive therapy in assisted reproductive technologies, leading to improved pregnancy rates. However, additional research addressing remaining scientific and methodo ... Full text Link to item Cite

Cost-effectiveness of HPV vaccines

Journal Article · April 11, 2006 Full text Cite

Acute myocardial infarction in pregnancy: a United States population-based study.

Journal Article Circulation · March 28, 2006 Featured Publication BACKGROUND: The purpose of this study was to determine the incidence, mortality, and risk factors for pregnancy-related acute myocardial infarction in the United States. METHODS AND RESULTS: The Nationwide Inpatient Sample for the years 2000 to 2002 was qu ... Full text Link to item Cite

Cost-effectiveness of extending cervical cancer screening intervals among women with prior normal pap tests.

Journal Article Obstet Gynecol · February 2006 Featured Publication OBJECTIVE: Annual cervical cancer screening in women with many prior normal Pap tests is common despite limited evidence on the cost-effectiveness of this strategy. We estimated the cost-effectiveness of screening women with 3 or more prior normal tests co ... Full text Link to item Cite

Management of adnexal mass.

Journal Article Evid Rep Technol Assess (Full Rep) · February 2006 OBJECTIVES: To assess diagnostic strategies for distinguishing benign from malignant adnexal masses. DATA SOURCES: MEDLINE(R) and reference lists of recent reviews; discharge data from the Nationwide Inpatient Sample. REVIEW METHODS: The major diagnostic m ... Link to item Cite

Cost-effectiveness analysis based on the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion Triage Study (ALTS).

Journal Article J Natl Cancer Inst · January 18, 2006 Featured Publication BACKGROUND: The ALTS (atypical squamous cells of undetermined significance [ASCUS] and low-grade squamous intraepithelial lesion [LSIL] Triage Study) suggests that, for women diagnosed with ASCUS, human papillomavirus (HPV) DNA testing followed by referral ... Full text Link to item Cite

Incidence and risk factors for stroke in pregnancy and the puerperium

Journal Article Obstetrical and Gynecological Survey · January 1, 2006 Full text Cite

The FIBROID Registry: symptom and quality-of-life status 1 year after therapy.

Journal Article Obstet Gynecol · December 2005 Featured Publication OBJECTIVES: To investigate the change in symptom severity and health-related quality of life among patients treated with uterine artery embolization for leiomyomata. METHODS: Using the Fibroid Registry for Outcomes Data (FIBROID), a multicenter, prospectiv ... Full text Link to item Cite

Comparison of self-reported smoking status and anonymous urinary cotinine testing in pregnancy

Conference American Journal of Obstetrics and Gynecology · December 2005 Full text Cite

Incidence and risk factors for stroke in pregnancy and the puerperium.

Journal Article Obstet Gynecol · September 2005 Featured Publication OBJECTIVE: To estimate the incidence, mortality, and risk factors for pregnancy-related stroke in the United States. METHODS: The Nationwide Inpatient Sample from the Healthcare Cost and Utilization Project of the Agency for Healthcare Research and Quality ... Full text Link to item Cite

Prospective data collection of a new procedure by a specialty society: the FIBROID registry.

Journal Article Obstet Gynecol · July 2005 Featured Publication OBJECTIVE: To describe registry methods and baseline patient demographics from a national sample of women undergoing uterine artery embolization for uterine leiomyomata. METHODS: Interventional radiology practices were recruited to submit data by a secure ... Full text Link to item Cite

The Fibroid Registry for outcomes data (FIBROID) for uterine embolization: short-term outcomes.

Journal Article Obstet Gynecol · July 2005 Featured Publication OBJECTIVE: To investigate the short-term safety of uterine embolization for leiomyomata in a large cohort of patients treated in a variety of clinical settings. METHODS: Examining the FIBROID Registry, a multicenter prospective voluntary registry of patien ... Full text Link to item Cite

Dissemination of Evidence-based Practice Center reports.

Journal Article Ann Intern Med · June 21, 2005 The Evidence-based Practice Center (EPC) program within the Agency for Healthcare Research and Quality (AHRQ) provides detailed evidence reports for partner organizations that they can translate into activities that improve patient care. A review of these ... Full text Link to item Cite

Estimating live birth rates after ovulation induction in polycystic ovary syndrome: sample size calculations for the pregnancy in polycystic ovary syndrome trial.

Journal Article Contemp Clin Trials · June 2005 Featured Publication Polycystic ovary syndrome (PCOS) affects approximately 5% of the female population, and is a leading cause of infertility, primarily secondary to anovulation. Clomiphene citrate has been standard therapy for ovulation induction in patients seeking pregnanc ... Full text Link to item Cite

Reply of the Authors

Journal Article Fertility and Sterility · June 2005 Full text Cite

FDG-PET for management of cervical and ovarian cancer.

Journal Article Gynecol Oncol · April 2005 Featured Publication OBJECTIVE: To assess the diagnostic performance of Positron Emission Tomography using fluorodeoxyglucose (FDG-PET) in comparison to conventional imaging modalities in the assessment of patients with cervical and ovarian cancer. METHODS: Studies published b ... Full text Link to item Cite

Levonorgestrel-releasing intrauterine system for menorrhagia cost less than hysterectomy over 5 years

Journal Article Evidence-based Obstetrics and Gynecology · March 1, 2005 Full text Cite

Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model.

Journal Article J Bone Miner Res · December 2004 UNLABELLED: To enhance the osteogenic activity of BMP, combination BMP2 and BMP7 gene transfer was performed. This approach led to a significant increase in osteoblastic differentiation of mesenchymal precursors compared with single BMP gene transfer in vi ... Full text Link to item Cite

Histological dating of timed endometrial biopsy tissue is not related to fertility status.

Journal Article Fertil Steril · November 2004 Featured Publication OBJECTIVE: To assess the ability of histological dating to discriminate between women of fertile and infertile couples. The utility of histological dating of endometrium in the evaluation of infertile couples is uncertain. DESIGN: Prospective multicenter s ... Full text Link to item Cite

Absence of secretory endometrium after false-positive home urine luteinizing hormone testing.

Journal Article Fertil Steril · November 2004 OBJECTIVE: To examine the proportion of cases with proliferative endometrium on biopsies performed after positive home urine LH testing. DESIGN: Multicenter clinical trial of the usefulness of endometrial biopsy in the evaluation of infertility, with women ... Full text Link to item Cite

Interobserver and intraobserver variability in the histological dating of the endometrium in fertile and infertile women.

Journal Article Fertil Steril · November 2004 OBJECTIVE: To assess effects of biopsy timing and fertility status on inter- and intraobserver variability in dating of the endometrium. DESIGN: Endometrial biopsy slides randomly selected from a multicenter study testing the utility of biopsy in the diagn ... Full text Link to item Cite

High-dose alendronate uncouples osteoclast and osteoblast function: a study in a rat spine pseudarthrosis model.

Journal Article Clin Orthop Relat Res · August 2004 The effect of alendronate on osteoclast and osteoblast function was studied in a novel spine pseudarthrosis model in rats. Sixty-three Sprague-Dawley rats were divided into three groups: control group (saline), therapeutic dose group (1 microg/kg/week), an ... Full text Link to item Cite

Surrogate end-points or primary outcomes in clinical trials in women with polycystic ovary syndrome?

Journal Article Hum Reprod · August 2004 There are multiple surrogate variables in polycystic ovary syndrome (PCOS), including biometric and biochemical parameters. The number of surrogate variables and their poor validity in relationship to primary clinical end-points pose major problems to cond ... Full text Link to item Cite

Testing for von Willebrand disease in women with menorrhagia: a systematic review.

Journal Article Obstet Gynecol · August 2004 Featured Publication OBJECTIVE: To review the evidence supporting screening of adult women with menorrhagia for von Willebrand disease. DATA SOURCES: MEDLINE search from January 1,1990, to December 31, 2003, for articles in English, using keywords "menorrhagia," "von Willebran ... Full text Link to item Cite

Should older women have antepartum testing to prevent unexplained stillbirth?

Journal Article Obstet Gynecol · July 2004 Featured Publication OBJECTIVE: Older women are at an increased risk for unexplained stillbirth late in pregnancy. The purpose of this study was to compare 3 strategies for the prevention of unexplained fetal death in women aged 35 years and older. We compared usual care (no a ... Full text Link to item Cite

Cost-effectiveness of combination thromboembolism prophylaxis in gynecologic oncology surgery.

Journal Article Gynecol Oncol · May 2004 OBJECTIVE: To compare the cost-effectiveness of external pneumatic compression devices with and without the addition of low-molecular-weight heparin for the prevention of deep vein thrombosis in high-risk surgical patients with gynecologic cancer. METHODS: ... Full text Link to item Cite

Absence of secretory endometrium after false positive home urine luteinizing hormone testing.

Conference JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION · February 1, 2004 Link to item Cite

A test can be reproducible but still not useful

Journal Article Fertility and Sterility · January 1, 2004 Good correlation between pathologists in assigning dates to endometrial biopsy specimens did not translate into good agreement in the dichotomous diagnosis of in-phase or out-of-phase. Design and analysis of reproducibility studies is complex; although alt ... Full text Cite

Decision science and cervical cancer.

Journal Article Cancer · November 1, 2003 Mathematical modeling is an effective tool for guiding cervical cancer screening, diagnosis, and treatment decisions for patients and policymakers. This article describes the use of mathematical modeling as outlined in five presentations from the Decision ... Full text Link to item Cite

Risk of cervical cancer associated with extending the interval between cervical-cancer screenings.

Journal Article N Engl J Med · October 16, 2003 Featured Publication BACKGROUND: Although contemporary guidelines suggest that the intervals between Papanicolaou tests can be extended to three years among low-risk women with previous negative tests, the excess risk of cervical cancer associated with less frequent than annua ... Full text Link to item Cite

Potential health and economic impact of adding a human papillomavirus vaccine to screening programs.

Journal Article JAMA · August 13, 2003 Featured Publication CONTEXT: Recently published results suggest that effective vaccines against cervical cancer-associated human papillomavirus (HPV) may become available within the next decade. OBJECTIVE: To examine the potential health and economic effects of an HPV vaccine ... Full text Link to item Cite

Primary care residents' characteristics and motives for providing differential medical treatment of cervical cancer screening

Journal Article Journal of the National Medical Association · July 1, 2003 Background: Cervical cancer screening rates in the United States are sub-optimal. Physician factors likely contribute to these lower rates. Previous studies provide inconclusive evidence about the association between physician characteristics and the likel ... Cite

The health and economic burden of genital warts in a set of private health plans in the United States.

Journal Article Clin Infect Dis · June 1, 2003 We estimated the prevalence of and costs associated with genital warts among privately insured individuals from the perspective of a private health plan in the United States. Health care claims data were derived from a sample of 3,664,686 privately insured ... Full text Link to item Cite

GnRHa treatment prior to surgery for uterine fibroids is not cost-effective

Journal Article Evidence-based Obstetrics and Gynecology · June 1, 2003 Cite

Effects of race and clinical factors on short-term outcomes of abdominal myomectomy.

Journal Article Obstet Gynecol · May 2003 Featured Publication OBJECTIVE: To estimate the effects of race and preoperative uterine anatomy on complication rates after myomectomy. METHODS: A total of 239 abdominal myomectomies were performed at Duke University Medical Center from July 1992 through June 1998. Charts wer ... Full text Link to item Cite

Costs and effectiveness of alternative strategies for cervical cancer screening in military beneficiaries.

Journal Article Obstet Gynecol · October 2002 Featured Publication OBJECTIVE: To estimate the potential effects, on costs and outcomes, of changes in sensitivity and specificity associated with new screening methods for cervical cancer in the military. METHODS: A Markov model of the natural history of cervical cancer was ... Full text Link to item Cite

Early physician experience with laparoscopically assisted vaginal hysterectomy and rates of surgical complications and conversion to laparotomy.

Journal Article Am J Obstet Gynecol · October 2002 OBJECTIVE: Our purpose was to determine whether the rates of conversion to laparotomy and surgical complication rate decrease with increasing physician experience with laparoscopically assisted vaginal hysterectomies (LAVH) in a large population-based admi ... Full text Link to item Cite

Management of uterine leiomyomata: what do we really know?

Journal Article Obstet Gynecol · July 2002 Featured Publication OBJECTIVE: To systematically review the literature on the surgical and nonsurgical management of uterine leiomyomata. DATA SOURCES: Published literature in English on the management of uterine leiomyomata published from 1975 through 2000 was identified in ... Full text Link to item Cite

Factors associated with patient-recalled smoking cessation advice in a low-income clinic.

Journal Article J Natl Med Assoc · May 2002 It is recommended that providers advise cessation to their patients who smoke. However, patients' reports of cessation advice indicate disparities based on patients' race, gender, age, and smoking level. Providers' reports do not corroborate these disparit ... Link to item Cite

Management of prolonged pregnancy.

Journal Article Evid Rep Technol Assess (Summ) · March 2002 Link to item Cite

Influence of stereotyping in smoking cessation counseling by primary care residents.

Journal Article Ethn Dis · 2002 This study examined racial differences in primary care residents' rates of addressing smoking cessation. We expected residents to have higher rates of addressing cessation with White female patients as compared with African-American or Hispanic female pati ... Link to item Cite

Mathematical models as research tools for HPV disease

Journal Article Papillomavirus Report · January 1, 2002 Cite

Technologic advances for evaluation of cervical cytology: is newer better?

Journal Article Obstet Gynecol Surv · December 2001 Among those women who have cervical cancer and have been screened, 14% to 33% of the cases represent failure to detect abnormalities that existed at the time of screening. New technologies intended to improve detection of cytologic abnormalities include li ... Full text Link to item Cite

How do residents prioritize smoking cessation for young "high-risk" women? Factors associated with addressing smoking cessation.

Journal Article Prev Med · October 2001 BACKGROUND: Sixty-seven percent of physicians report advising their smoking patients to quit. Primary care residents' priorities for preventive health for a young "high-risk" female are unknown. Factors related to residents addressing smoking also need exa ... Full text Link to item Cite

Cost-effectiveness of universal cystoscopy to identify ureteral injury at hysterectomy.

Journal Article Obstet Gynecol · May 2001 Featured Publication OBJECTIVE: To evaluate the cost-effectiveness of routine cystoscopy at the time of abdominal, vaginal, and laparoscopically assisted vaginal hysterectomy in terms of cost per ureteral injury identified and treated. METHODS: Using a hospital-based perspecti ... Full text Link to item Cite

Vaginal mesh erosion after abdominal sacral colpopexy.

Journal Article Am J Obstet Gynecol · February 2001 OBJECTIVE: Our goal was to compare the prevalence of vaginal mesh erosion between abdominal sacral colpopexy and various sacral colpoperineopexy procedures. STUDY DESIGN: We undertook a retrospective analysis of all sacral colpopexies and colpoperineopexie ... Full text Link to item Cite

The ethics of aggregation and hormone replacement therapy.

Journal Article Health Care Anal · 2001 The use of aggregated quality of life estimates in the formation of public policy and practice guidelines raises concerns about the moral relevance of variability in values in preferences for health care. This variability may reflect unique and deeply held ... Full text Link to item Cite

Management of uterine fibroids.

Journal Article Evid Rep Technol Assess (Summ) · January 2001 Link to item Cite

Which women with stress incontinence require urodynamic evaluation?

Journal Article Am J Obstet Gynecol · January 2001 OBJECTIVE: This study was undertaken to determine the predictive value of the symptom of stress urinary incontinence and to evaluate the ability of other factors suggested by a published Agency for Health Care Policy and Research guideline for the discrimi ... Full text Link to item Cite

Commentary

Journal Article Evidence-based Obstetrics and Gynecology · January 1, 2001 Full text Cite

Antepartum or postpartum isoniazid treatment of latent tuberculosis infection.

Journal Article Obstet Gynecol · November 2000 OBJECTIVE: To compare health outcomes and costs of different strategies for treatment of latent tuberculosis infection in pregnancy. METHODS: Using a Markov decision-analysis model, the following three strategies were evaluated for treatment of latent tube ... Full text Link to item Cite

Setting the target for a better cervical screening test: characteristics of a cost-effective test for cervical neoplasia screening.

Journal Article Obstet Gynecol · November 2000 Featured Publication OBJECTIVE: To determine the potential effects on costs and outcomes of changes in sensitivity and specificity with new screening methods for cervical cancer. METHODS: Using a Markov model of the natural history of cervical cancer, we estimated the effects ... Full text Link to item Cite

Mathematical model for the natural history of human papillomavirus infection and cervical carcinogenesis.

Journal Article Am J Epidemiol · June 15, 2000 Featured Publication The authors constructed a Markov model as part of a systematic review of cervical cytology conducted at the Duke University Evidence-based Practice Center (Durham, North Carolina) between October 1997 and September 1998. The model incorporated states for h ... Full text Link to item Cite

Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review.

Journal Article Ann Intern Med · May 16, 2000 PURPOSE: To evaluate the accuracy of conventional and new methods of Papanicolaou (Pap) testing when used to detect cervical cancer and its precursors. DATA SOURCES: Systematic search of English-language literature through October 1999 using MEDLINE, EMBAS ... Full text Link to item Cite

Cost-effectiveness of deep venous thrombosis prophylaxis in gynecologic oncology surgery.

Journal Article Obstet Gynecol · February 2000 OBJECTIVE: To estimate the cost-effectiveness of preventive strategies for deep vein thrombosis (DVT) in patients undergoing surgery for gynecologic cancer. METHODS: A model was constructed to estimate the costs and outcomes associated with the use of exte ... Full text Link to item Cite

Effect of augmentation on the mechanics of vertebral wedge fractures.

Journal Article Spine (Phila Pa 1976) · January 15, 2000 STUDY DESIGN: The effect of cement augmentation of wedge-fractured vertebral bodies on spine segment compliance was studied in 16 cadaver specimens. OBJECTIVES: 1) To assess the mechanical effects of cement augmentation of vertebral wedge fractures. 2) To ... Full text Link to item Cite

Preventive health services received by minority women aged 45-64 and the goals of healthy people 2000.

Journal Article Womens Health Issues · 2000 We attempted to evaluate the preventive health services received by minority women aged 45-64 in an underserved region of Boston. We compared two surveys of disease burden and preventive health services to national data sets and the goals of Healthy People ... Full text Link to item Cite

Universal HIV screening of pregnant women in England would be cost-effective in areas of high prevalence

Journal Article Evidence-based Obstetrics and Gynecology · January 1, 2000 OBJECTIVE To estimate the cost-effectiveness of a voluntary HIV-screening programme for all pregnant women. DESIGN Cost-effectiveness analysis. Only costs to the National Health Service were considered. SETTING England. INTERVENTION Serological screening f ... Full text Cite

Systemic methotrexate treatment of tubal pregnancy was more costly than laparoscopic salpingostomy

Journal Article Evidence-based Obstetrics and Gynecology · January 1, 2000 OBJECTIVE To compare the cost of treatment of unruptured tubal pregnancy with systemic methotrexate and laparoscopic salpingostomy. DESIGN Cost-minimization evaluation based on a multicentre, randomized controlled trial. Allocation was blocked and stratifi ... Full text Cite

Risk adjustment for complications of hysterectomy: limitations of routinely collected administrative data.

Journal Article Am J Obstet Gynecol · September 1999 Featured Publication OBJECTIVE: We sought to determine the utility of routinely collected administrative data for risk adjustment for complications of hysterectomy. STUDY DESIGN: Using abstracted discharge data on 107, 648 women undergoing hysterectomy in North Carolina from 1 ... Full text Link to item Cite

Evaluating new (and old) technologies: The role of economic analysis

Journal Article Journal of Gynecologic Techniques · August 20, 1999 As new technologies become available for preventing and treating illness, the costs of health care will inevitably rise. Those who develop, assess, and use new interventions need to become familiar with the methods of economic analysis. Cost-minimization s ... Cite

Cost-effectiveness of treatment of early stage endometrial cancer.

Journal Article Gynecol Oncol · August 1999 OBJECTIVE: The purpose of this study was to determine the average life-years gained and cost per life-year gained in treatment of early endometrial cancer. METHODS: We performed a decision analysis using statistical models for survival after treatment for ... Full text Link to item Cite

Evaluation of cervical cytology.

Journal Article Evid Rep Technol Assess (Summ) · January 1999 Link to item Cite

Cost-effectiveness of mandatory compared with voluntary screening for human immunodeficiency virus in pregnancy.

Journal Article Obstet Gynecol · February 1998 Featured Publication OBJECTIVE: To determine the cost-effectiveness of mandatory screening for human immunodeficiency virus (HIV) in pregnancy compared with that of voluntary screening under varying assumptions about patient behavior. METHODS: Using a health care system perspe ... Full text Link to item Cite

Prevention of respiratory distress syndrome: cost-effectiveness for managing idiopathic preterm labor

Journal Article Acta Diabetologica Latina · December 1, 1997 OBJECTIVE: To determine the relative cost-effectiveness of three strategies for preventing respiratory distress syndrome (RDS) resulting from preterm labor and delivery: (1) empiric tocolysis with betamimetic agonists and treatment with corticosteroids (TR ... Cite

Cost-effectiveness of fetal lung maturity testing in preterm labor.

Journal Article Obstet Gynecol · November 1997 OBJECTIVE: To determine the marginal cost-effectiveness of two strategies for preventing respiratory distress syndrome (RDS) resulting from preterm birth: 1) tocolysis with beta-mimetic agonists and treatment with corticosteroids (TREATALL), and 2) amnioce ... Full text Link to item Cite

Preoperative coagulation testing on a gynecologic oncology service.

Journal Article Obstet Gynecol · March 1994 OBJECTIVE: To determine the prevalence and clinical significance of abnormalities of preoperative coagulation tests in gynecologic oncology patients. METHODS: Three hundred fifty-one patients presenting for inpatient surgical procedures on the gynecologic ... Link to item Cite

Serum progesterone levels following vaginal administration of progesterone during the luteal phase.

Journal Article Fertil Steril · January 1987 We measured serum progesterone (P) levels after administration of 400 mg P vaginal suppositories to women during the luteal phase of the menstrual cycle. Blood samples were obtained before suppository insertion and at five intervals up to 8 hours after ins ... Link to item Cite