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Edward Charles Halperin

Edward Charles Halperin

R. J. Reynolds Distinguished Professor Emeritus of Medical Education, in the School of Medicine
Radiation Oncology
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Selected Publications

Particle therapy and treatment of cancer.

Journal Article Lancet Oncol · August 2006 The desire of radiation oncologists and medical physicists to maximise the radiation dose to the tumour while minimising that to healthy tissues has led to attempts to improve the dose distributions and biological effects achievable with photons and electr ... Full text Link to item Cite

What or who killed Alexander the Great?

Journal Article Pharos Alpha Omega Alpha Honor Med Soc · 2006 Link to item Cite

Should an academic radiation oncologist be allowed to "opt out" of medicare?

Journal Article J Am Coll Radiol · October 2005 Federal law permits physicians to "opt out" of Medicare. When a radiation oncologist chooses this option, he or she may neither bill nor collect from Medicare, but may legally attempt to charge and collect what he or she considers the value of services pro ... Full text Link to item Cite

A population-based study of the prevalence and influence of gifts to radiation oncologists from pharmaceutical companies and medical equipment manufacturers.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2004 PURPOSE: Hospital-based physicians are responsible for the purchase of expensive equipment. Little is known about the influence of gift giving on their behavior. We wanted to ascertain the prevalence of gift giving from the pharmaceutical industry and medi ... Full text Link to item Cite

Paleo-oncology: the role of ancient remains in the study of cancer.

Journal Article Perspect Biol Med · 2004 Paleo-oncology is the study of carcinomas and sarcomas in ancient human populations and their hominid precursors. These populations are informative concerning the possible influences on cancer of morphologic and functional evolution, diet, lifestyle, and o ... Full text Link to item Cite

Unrelated umbilical cord blood transplantation in adult patients.

Journal Article Biol Blood Marrow Transplant · December 2003 Since January 1996, we have administered myeloablative therapy followed by infusion of unrelated umbilical cord blood cells in 57 adult patients with high-risk disease. The median age was 31 years (range, 18-58 years), and the median weight was 70 kg (rang ... Full text Link to item Cite

Free speech and snake oil.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2003 Full text Link to item Cite

Is the long-term survival of patients with intracranial glioblastoma multiforme overstated?

Journal Article Cancer · October 15, 2003 BACKGROUND: The 5-year survival rate for intracranial glioblastoma multiforme (GBM) has remained at 4-5% for the last 30 years, in spite of multiple randomized prospective trials. The authors hypothesized, based on the literature, that even this remarkably ... Full text Link to item Cite

Selection of patients with melanoma brain metastases for aggressive treatment.

Journal Article Am J Clin Oncol · August 2003 The purpose of this study was to determine prognostic factors for patients with melanoma brain metastases that can be recommended for patient selection for clinical trials. A retrospective review was conducted of 65 patients irradiated for brain metastases ... Full text Link to item Cite

High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas.

Journal Article J Clin Oncol · June 1, 2003 PURPOSE: We evaluated the usefulness of a treatment regimen that included high-dose chemotherapy (HDC) with autologous stem-cell rescue (ASCR) in patients with newly diagnosed pineoblastoma (PBL). PATIENTS AND METHODS: Twelve patients with PBL were initial ... Full text Link to item Cite

Low-dose radiation for posttransplant lymphoproliferative disorder.

Journal Article Am J Clin Oncol · April 2003 Initial treatment for posttransplant lymphoproliferative disorder (PTLD) usually involves discontinuation of immunosuppressants. Anti-CD20 monoclonal antibody and/or antivirals are typically employed for persistent disease. Chemotherapy is generally reserv ... Full text Link to item Cite

Prospective study of neuropsychologic testing and quality-of-life assessment of adults with primary malignant brain tumors.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2003 PURPOSE: To identify the characteristics of adult patients with newly diagnosed primary brain tumors associated with identifiable deficits in neuropsychologic function to target interventions to improve function and quality of life (QOL). MATERIALS AND MET ... Full text Link to item Cite

The hidden persuaders: subtle advertising in radiation oncology.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2002 Full text Link to item Cite

The corporate presence at oncology meetings.

Journal Article Am J Clin Oncol · October 2002 Full text Link to item Cite

An evaluation of the relationship between the quality of prophylactic cranial radiotherapy in childhood acute leukemia and institutional experience: a Quality Assurance Review Center-Pediatric Oncology Group study.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2002 PURPOSE: The Pediatric Oncology Group Protocol 9404 was a prospective clinical trial of two forms of chemotherapy in childhood T-cell acute lymphoblastic leukemia and advanced stage T-cell lymphoblastic non-Hodgkin's lymphoma. The protocol called for proph ... Full text Link to item Cite

Should academic medical centers conduct clinical trials of the efficacy of intercessory prayer?

Journal Article Acad Med · August 2001 Intercessory prayers for health or healing are requests to an object of worship for the preservation or restoration of health. There has been a recent proliferation of clinical trials that compare the health outcome of a group of prayed-for patients with t ... Full text Link to item Cite

Non-human to human organ transplantation: its biologic basis and a potential role for radiation therapy.

Journal Article Int J Cancer · April 20, 2001 There is an inadequate supply of human donor organs for transplantation. Xenotransplantation, the transplantation of organs from non-human animals to humans, is one of the potential solutions to this problem. The pig appears to be the preferred donor. For ... Full text Link to item Cite

Duration of symptoms prior to diagnosis is related inversely to presenting disease stage in children with medulloblastoma.

Journal Article Cancer · April 15, 2001 BACKGROUND: The authors tested the hypothesis that children with a longer duration of symptoms prior to diagnosis of medulloblastoma have more advanced disease. In addition, they evaluated whether there are correlations between gender, duration of presenti ... Full text Link to item Cite

The Jewish problem in U.S. medical education, 1920-1955.

Journal Article J Hist Med Allied Sci · April 2001 Full text Link to item Cite

Second malignant neoplasms of the head and neck in survivors of retinoblastoma.

Journal Article Ear Nose Throat J · February 2001 Retinoblastoma is a malignant tumor of the embryonic retina. Although it is rare, it is the most common primary eye tumor of childhood. Life expectancy following treatment is now excellent, but survivors who have heritable retinoblastoma face an increased ... Link to item Cite

Particle therapy and treatment of cancer.

Journal Article Lancet Oncol · August 2006 The desire of radiation oncologists and medical physicists to maximise the radiation dose to the tumour while minimising that to healthy tissues has led to attempts to improve the dose distributions and biological effects achievable with photons and electr ... Full text Link to item Cite

What or who killed Alexander the Great?

Journal Article Pharos Alpha Omega Alpha Honor Med Soc · 2006 Link to item Cite

Should an academic radiation oncologist be allowed to "opt out" of medicare?

Journal Article J Am Coll Radiol · October 2005 Federal law permits physicians to "opt out" of Medicare. When a radiation oncologist chooses this option, he or she may neither bill nor collect from Medicare, but may legally attempt to charge and collect what he or she considers the value of services pro ... Full text Link to item Cite

A population-based study of the prevalence and influence of gifts to radiation oncologists from pharmaceutical companies and medical equipment manufacturers.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2004 PURPOSE: Hospital-based physicians are responsible for the purchase of expensive equipment. Little is known about the influence of gift giving on their behavior. We wanted to ascertain the prevalence of gift giving from the pharmaceutical industry and medi ... Full text Link to item Cite

Paleo-oncology: the role of ancient remains in the study of cancer.

Journal Article Perspect Biol Med · 2004 Paleo-oncology is the study of carcinomas and sarcomas in ancient human populations and their hominid precursors. These populations are informative concerning the possible influences on cancer of morphologic and functional evolution, diet, lifestyle, and o ... Full text Link to item Cite

Unrelated umbilical cord blood transplantation in adult patients.

Journal Article Biol Blood Marrow Transplant · December 2003 Since January 1996, we have administered myeloablative therapy followed by infusion of unrelated umbilical cord blood cells in 57 adult patients with high-risk disease. The median age was 31 years (range, 18-58 years), and the median weight was 70 kg (rang ... Full text Link to item Cite

Free speech and snake oil.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2003 Full text Link to item Cite

Is the long-term survival of patients with intracranial glioblastoma multiforme overstated?

Journal Article Cancer · October 15, 2003 BACKGROUND: The 5-year survival rate for intracranial glioblastoma multiforme (GBM) has remained at 4-5% for the last 30 years, in spite of multiple randomized prospective trials. The authors hypothesized, based on the literature, that even this remarkably ... Full text Link to item Cite

Selection of patients with melanoma brain metastases for aggressive treatment.

Journal Article Am J Clin Oncol · August 2003 The purpose of this study was to determine prognostic factors for patients with melanoma brain metastases that can be recommended for patient selection for clinical trials. A retrospective review was conducted of 65 patients irradiated for brain metastases ... Full text Link to item Cite

High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas.

Journal Article J Clin Oncol · June 1, 2003 PURPOSE: We evaluated the usefulness of a treatment regimen that included high-dose chemotherapy (HDC) with autologous stem-cell rescue (ASCR) in patients with newly diagnosed pineoblastoma (PBL). PATIENTS AND METHODS: Twelve patients with PBL were initial ... Full text Link to item Cite

Low-dose radiation for posttransplant lymphoproliferative disorder.

Journal Article Am J Clin Oncol · April 2003 Initial treatment for posttransplant lymphoproliferative disorder (PTLD) usually involves discontinuation of immunosuppressants. Anti-CD20 monoclonal antibody and/or antivirals are typically employed for persistent disease. Chemotherapy is generally reserv ... Full text Link to item Cite

Prospective study of neuropsychologic testing and quality-of-life assessment of adults with primary malignant brain tumors.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2003 PURPOSE: To identify the characteristics of adult patients with newly diagnosed primary brain tumors associated with identifiable deficits in neuropsychologic function to target interventions to improve function and quality of life (QOL). MATERIALS AND MET ... Full text Link to item Cite

The hidden persuaders: subtle advertising in radiation oncology.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2002 Full text Link to item Cite

The corporate presence at oncology meetings.

Journal Article Am J Clin Oncol · October 2002 Full text Link to item Cite

An evaluation of the relationship between the quality of prophylactic cranial radiotherapy in childhood acute leukemia and institutional experience: a Quality Assurance Review Center-Pediatric Oncology Group study.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2002 PURPOSE: The Pediatric Oncology Group Protocol 9404 was a prospective clinical trial of two forms of chemotherapy in childhood T-cell acute lymphoblastic leukemia and advanced stage T-cell lymphoblastic non-Hodgkin's lymphoma. The protocol called for proph ... Full text Link to item Cite

Should academic medical centers conduct clinical trials of the efficacy of intercessory prayer?

Journal Article Acad Med · August 2001 Intercessory prayers for health or healing are requests to an object of worship for the preservation or restoration of health. There has been a recent proliferation of clinical trials that compare the health outcome of a group of prayed-for patients with t ... Full text Link to item Cite

Non-human to human organ transplantation: its biologic basis and a potential role for radiation therapy.

Journal Article Int J Cancer · April 20, 2001 There is an inadequate supply of human donor organs for transplantation. Xenotransplantation, the transplantation of organs from non-human animals to humans, is one of the potential solutions to this problem. The pig appears to be the preferred donor. For ... Full text Link to item Cite

Duration of symptoms prior to diagnosis is related inversely to presenting disease stage in children with medulloblastoma.

Journal Article Cancer · April 15, 2001 BACKGROUND: The authors tested the hypothesis that children with a longer duration of symptoms prior to diagnosis of medulloblastoma have more advanced disease. In addition, they evaluated whether there are correlations between gender, duration of presenti ... Full text Link to item Cite

The Jewish problem in U.S. medical education, 1920-1955.

Journal Article J Hist Med Allied Sci · April 2001 Full text Link to item Cite

Second malignant neoplasms of the head and neck in survivors of retinoblastoma.

Journal Article Ear Nose Throat J · February 2001 Retinoblastoma is a malignant tumor of the embryonic retina. Although it is rare, it is the most common primary eye tumor of childhood. Life expectancy following treatment is now excellent, but survivors who have heritable retinoblastoma face an increased ... Link to item Cite

Overpriced technology in radiation oncology.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2000 Full text Link to item Cite

Grievances against physicians: 11 years' experience of a medical society grievance committee.

Journal Article West J Med · October 2000 OBJECTIVE: To understand causes of patient dissatisfaction that result in complaints. DESIGN: Grievances received by the grievance committee between January 1, 1989, and January 1, 2000, were reviewed. SETTING: A 2-county area of North Carolina. SUBJECTS: ... Full text Link to item Cite

Neonatal neoplasms.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2000 PURPOSE: To describe neoplasms diagnosed in children Full text Link to item Cite

Whatever happened to psychotherapy?

Journal Article N C Med J · 2000 Link to item Cite

The influence of hyperbaric oxygen therapy and irradiation on hydroxyapatite ocular implant exposure and fibrovascular ingrowth in New Zealand white rabbits.

Journal Article Ophthalmic Plast Reconstr Surg · November 1999 PURPOSE: Lack of adequate fibrovascular ingrowth has been implicated as a cause of exposure of hydroxyapatite (HA) implants in anophthalmic sockets. We investigated the vasculopathic effects of external beam irradiation, and the fibrovascular-enhancement e ... Full text Link to item Cite

Anesthesia for pediatric external beam radiation therapy.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 1999 BACKGROUND: For very young patients, anesthesia is often required for radiotherapy. This results in multiple exposures to anesthetic agents over a short period of time. We report a consecutive series of children anesthetized for external beam radiation the ... Full text Link to item Cite

Fractionated external-beam radiation therapy for meningiomas of the cavernous sinus.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 1999 PURPOSE: Despite advances in microsurgical technique, many cavernous sinus meningiomas remain unresectable or only partially resectable, prompting referral of patients for radiation therapy. Stereotactic radiosurgery is recommended as therapy at some insti ... Full text Link to item Cite

Kidney cancer.

Journal Article Lancet · February 13, 1999 Full text Link to item Cite

Defining the superior border of posterior fossa radiation treatment fields.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 1998 PURPOSE: Lateral posterior fossa treatment fields are usually defined on traditional simulation films based on bony landmarks. The superior field border, intended to include the apex of the tentorium cerebelli, is frequently difficult to define. While sagi ... Full text Link to item Cite

Toxicity, pharmacology and feasibility of administration of PEG-L-asparaginase as consolidation therapy in patients undergoing bone marrow transplantation for acute lymphoblastic leukemia.

Journal Article Bone Marrow Transplant · May 1998 We attempted to administer PEG-L-asparaginase (PEG-L-A) following hematologic recovery to 38 patients undergoing autologous or allogeneic marrow transplantation for acute lymphoblastic leukemia (ALL). Twenty-four patients (12 of 22 receiving allogeneic and ... Full text Link to item Cite

Event-free survival of children with biologically favourable neuroblastoma based on the degree of initial tumour resection: results from the Pediatric Oncology Group.

Journal Article Eur J Cancer · October 1997 We analysed the 2-year event-free survival (EFS) of 49 patients 1 year of age and older, with stage 2B or 3 neuroblastoma, treated on Pediatric Oncology Group protocols 8742 and 9244, with respect to the degree of tumour resection at diagnosis. The 2-year ... Full text Link to item Cite

Are there sex biases in standardized tests of radiation oncology knowledge?

Journal Article J Clin Oncol · July 1997 PURPOSE/OBJECTIVE: Recent studies have identified biases directed against women in standardized tests. We tested for the existence of such biases in the American College of Radiology (ACR) In-Training Examination in Radiation Oncology and the American Boar ... Full text Link to item Cite

Long-term results of therapy for stage C neuroblastoma.

Journal Article J Surg Oncol · November 1996 BACKGROUND: The appropriate therapy for Stage C neuroblastoma (NB) is uncertain. Because of the need for information applicable to the development of new randomized trials, we deemed it appropriate to investigate the patient characteristics, survival, patt ... Full text Link to item Cite

New and recurrent tumors in germinal retinoblastoma: is there a treatment effect?

Journal Article Ophthalmic Genet · September 1996 Patients with germinal retinoblastoma (those with bilateral disease or positive family history) have a mutation which puts them at risk for developing new tumors. It is unclear whether the frequency of new tumor development is effected by the type of treat ... Full text Link to item Cite

Is there a correlation between duration of presenting symptoms and stage of medulloblastoma at the time of diagnosis?

Journal Article Cancer · August 15, 1996 BACKGROUND: Does a "delay in diagnosis" lead to a child being diagnosed with advanced stage as opposed to early stage medulloblastoma? Correlation between the duration of a patient's presenting symptoms and stage at diagnosis was examined. METHODS: The pop ... Full text Link to item Cite

Impact of radiation technique upon the outcome of treatment for medulloblastoma.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 1996 Craniospinal irradiation (CSI) is an essential component of the therapy of medulloblastoma. Because medulloblastoma disseminates via the cerebrospinal fluid (CSF), CSI technique involves the irradiation of all CSF-bearing areas which are at risk for tumor ... Full text Link to item Cite

Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients.

Journal Article N Engl J Med · July 18, 1996 BACKGROUND: Transplantation of bone marrow from unrelated donors is limited by a lack of HLA-matched donors and the risk of graft-versus-host disease (GVHD). Placental blood from sibling donors can reconstitute hematopoiesis. We report preliminary results ... Full text Link to item Cite

Resolution of Budd-Chiari syndrome following bone marrow transplantation for paroxysmal nocturnal haemoglobinuria.

Journal Article Br J Haematol · March 1996 Thrombosis of the hepatic veins (Budd-Chiari syndrome) is a life-threatening thrombotic complication which can occur in patients with paroxysmal nocturnal haemoglobinuria (PNH). Despite aggressive medical and surgical therapy, mortality from Budd-Chiari sy ... Full text Link to item Cite

A phase III randomized prospective trial of external beam radiotherapy, mitomycin C, carmustine, and 6-mercaptopurine for the treatment of adults with anaplastic glioma of the brain. CNS Cancer Consortium.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 1996 PURPOSE: This study was designed to evaluate strategies to overcome the resistance of anaplastic gliomas of the brain to external beam radiotherapy (ERT) plus carmustine (BCNU). Patients were > or = 15 years of age, had a histologic diagnosis of malignant ... Full text Link to item Cite

Fabrication and testing of a device capable of reducing the incidence of ventricular shunt promoted metastasis.

Journal Article J Neurooncol · January 1996 PURPOSE/OBJECTIVE: Some malignant brain tumors shed cells into the cerebrospinal fluid (CSF). These tumors may implant throughout the neuroaxis via the CSF. With the placement of a ventriculoperitoneal (VP) or ventriculoatrial (VA) shunt, tumor cells free- ... Full text Link to item Cite

Is tenure irrelevant for academic clinicians?

Journal Article South Med J · November 1995 Academic tenure is the guarantee that a faculty member cannot be arbitrarily dismissed. The tenure system developed to maintain academics free of external pressure and coercion, and in dramatic instances tenure has been used to defend academic freedom. Wit ... Full text Link to item Cite

What medical schools and universities can learn from one another.

Journal Article Acad Med · October 1995 Colleges and universities devoted to undergraduate education and non-medical graduate education (hereafter called "universities") have much to teach medical schools and much to learn from them. Universities and medical schools differ significantly in their ... Full text Link to item Cite

Malignant gliomas in older adults with poor prognostic signs. Getting nowhere, and taking a long time to do it.

Journal Article Oncology (Williston Park) · March 1995 The median survival time of adults with supratentorial malignant glioma treated in clinical studies with surgery, 6 weeks of external-beam radiotherapy, and carmustine (BiCNU) is approximately 1 year. This poor survival time is almost certainly optimistic, ... Link to item Cite

Recipient Kupffer cell influx into xenografted liver.

Journal Article Dig Dis Sci · March 1995 Previously we reported that the combination of total lymphoid irradiation (TLI), cyclosporine A (CsA), and splenectomy have an immunosuppressive effect sufficient to significantly prolong liver xenograft survival in the LVG hamster to the LEW rat model. Us ... Full text Link to item Cite

Techniques of experimental animal radiotherapy.

Journal Article Lab Anim Sci · October 1994 Animal research is a crucial component of the generation of new knowledge in human and veterinary medicine. Total body irradiation, whole brain irradiation, total lymphoid irradiation, and local field irradiation of experimental animals are powerful tools ... Link to item Cite

Cyclophosphamide, doxorubicin, vincristine, and prednisone for primary central nervous system lymphoma: short-duration response and multifocal intracerebral recurrence preceding radiotherapy.

Journal Article Neurology · September 1994 The activity of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in the treatment of primary central nervous system lymphoma (PCNSL) prior to radiotherapy was studied in six patients. Primary lesions were reduced by 80% or more on contrast ... Full text Link to item Cite

A prospective study of short-course radiotherapy in poor prognosis glioblastoma multiforme.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 1994 PURPOSE: Older age and poor performance status at presentation are unfavorable prognostic factors for patients with glioblastoma multiforme. Some studies suggest a shorter, palliative course of radiotherapy may confer similar benefits as compared to a radi ... Full text Link to item Cite

Eureka! It's a negative study!

Journal Article N C Med J · February 1994 Link to item Cite

Management of pineal non-germinoma germ cell tumor with residual teratoma and normal alpha-fetoprotein.

Journal Article Med Pediatr Oncol · 1994 A 16-year-old white male presented with multiple abnormal extraocular movements secondary to an enhancing pineal tumor. Subtotal resection of the lesion revealed a mixed malignant germ cell tumor. The preoperative serum alpha-fetoprotein (AFP) was markedly ... Full text Link to item Cite

Well differentiated astrocytoma occurring nine years after radiation therapy for medulloblastoma.

Journal Article Clin Neuropathol · 1994 Conventional treatment for medulloblastoma includes surgical resection followed by craniospinal irradiation, with the potential risk of subsequent radiotherapy-induced secondary neoplasms. We report a 23-year-old woman previously irradiated nine years earl ... Link to item Cite

Arteriovenous malformation mimicking recurrent medulloblastoma.

Journal Article Med Pediatr Oncol · 1994 Magnetic resonance imaging (MRI) is becoming the method of choice for evaluation of central nervous system tumors. However, the sensitivity of this modality raises concern that new lesions in patients previously diagnosed with a brain tumor may not necessa ... Full text Link to item Cite

Surgery, hyperfractionated craniospinal irradiation, and adjuvant chemotherapy in the management of supratentorial embryonal neuroepithelial neoplasms in children.

Journal Article Surg Neurol · October 1993 Supratentorial embryonal neuroepithelial tumors are undifferentiated neoplasms. We have used this term in preference to the controversial classification primitive neuroectodermal tumors (PNET). These lesions in children are malignant neoplasms which are us ... Full text Link to item Cite

Final results of a study of escalating doses of hyperfractionated radiotherapy in brain stem tumors in children: a Pediatric Oncology Group study.

Journal Article Int J Radiat Oncol Biol Phys · September 30, 1993 PURPOSE: In September 1984, the Pediatric Oncology Group began accrual to a Phase I/II study designed to assess the efficacy and toxicity of sequentially escalated doses of hyperfractionated (twice daily) radiotherapy in children with poor-prognosis brain ... Full text Link to item Cite

Multiple fraction-per-day radiotherapy for patients with brain stem tumors.

Journal Article J Neurooncol · August 1993 Brain stem tumors are among the most resistant brain tumors to therapy. The majority progress within 18 months of diagnosis and treatment. Multiple-fraction-per-day (MFD) radiotherapy would theoretically allow higher total doses of radiotherapy to be deliv ... Full text Link to item Cite

The use of G-CSF during craniospinal irradiation.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 1993 Full text Link to item Cite

The management of desmoid tumors.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 1993 PURPOSE: To determine the efficacy of different treatment modalities for desmoid tumors. MATERIALS AND METHODS: We reviewed the treatment of 40 patients with histologically confirmed desmoid tumors seen at Duke University Medical Center between 1974 and 19 ... Full text Link to item Cite

Efficacy and toxicity of 9-beta-D-arabinofuranosylguanine (araG) as an agent to purge malignant T cells from murine bone marrow: application to an in vivo T-leukemia model.

Journal Article Leukemia · August 1993 9-beta-D-Arabinofuranosylguanine (araG), an analog of deoxyguanosine which is not degraded by purine nucleoside phosphorylase, has been previously shown in in vitro studies by our laboratory to be effective in purging malignant T cells from human bone marr ... Link to item Cite

An analysis of radiotherapy data from the CNS cancer consortium's randomized prospective trial comparing AZQ to BCNU in the treatment of patients with primary malignant brain tumors. The CNS cancer consortium.

Journal Article Am J Clin Oncol · August 1993 The CNS Cancer Consortium has conducted a phase III study comparing diaziquone (AZQ) with carmustine (BCNU) in the treatment of adults with primary anaplastic glial brain tumors. Patients eligible for this study were 18 years of age or older at the time of ... Full text Link to item Cite

A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. CNS Cancer Consortium.

Journal Article Int J Radiat Oncol Biol Phys · June 15, 1993 PURPOSE: The object of this study was to ascertain the value of topical ascorbic acid in the prevention of radiation dermatitis. METHODS AND MATERIALS: Patients with primary or metastatic brain tumors were eligible. Patients applied a topical solution, twi ... Full text Link to item Cite

Concerning the inferior portion of the spinal radiotherapy field for malignancies that disseminate via the cerebrospinal fluid.

Journal Article Int J Radiat Oncol Biol Phys · May 20, 1993 PURPOSE: Many radiotherapists widen the inferior aspect of the craniospinal irradiation field to encompass the sacroiliac joints and "cover the sacral nerve roots." This is commonly referred to as a "spade" field. Other therapists, however, reject the noti ... Full text Link to item Cite

Malignant glioma--timing of response to radiation therapy.

Journal Article Int J Radiat Oncol Biol Phys · April 2, 1993 PURPOSE: The response of malignant gliomas to radiation was examined retrospectively in 71 patients with newly diagnosed supratentorial malignant gliomas. Questions asked included frequency, timing and clinical significance of response. METHODS AND MATERIA ... Full text Link to item Cite

Comparison of serial PET and MRI scans in a pediatric patient with a brainstem glioma.

Journal Article Med Pediatr Oncol · 1993 Profound clinical deficits may be associated with insults to the brainstem, making management of patients with brainstem gliomas very complex. Small changes in the radiographic appearance of a brainstem tumor may be associated with significant clinical det ... Full text Link to item Cite

125I embedded in an orbital prosthesis for retreatment of recurrent retinoblastoma.

Journal Article Med Dosim · 1993 The application of radiation therapy in the retreatment of unilateral recurrent retinoblastoma presents a very difficult dilemma in which consideration must be given to preservation of vision in the remaining eye while tumoricidal doses of irradiation are ... Full text Link to item Cite

Randomized comparison of diaziquone and carmustine in the treatment of adults with anaplastic glioma.

Journal Article J Clin Oncol · January 1993 PURPOSE: We conducted a phase III trial comparing intravenous (IV) diaziquone (AZQ) and carmustine (BCNU) as single agents in patients with cerebral anaplastic gliomas who had received surgery and radiotherapy. Its purpose was to compare the efficacy of AZ ... Full text Link to item Cite

Multiple authorship in two English-language journals in radiation oncology.

Journal Article Acad Med · December 1992 Multiple authorship is the listing of more than one person as author of an article in the scholarly literature. Editors, researchers, and others in science publishing have raised concerns about the increasing number of authors being listed per article, the ... Full text Link to item Cite

Multiple-fraction-per-day external beam radiotherapy for adults with supratentorial malignant gliomas.

Journal Article J Neurooncol · November 1992 The prognosis following therapy for adults with supratentorial malignant gliomas is poor. Standard therapy of 60 Gy of external beam radiotherapy with chemotherapy achieves a median survival time of 35 to 51 weeks following surgery. A variety of innovative ... Full text Link to item Cite

Successful therapy for trilateral retinoblastoma.

Journal Article Am J Ophthalmol · July 15, 1992 Trilateral retinoblastoma, the intracranial malignancy associated with bilateral retinoblastoma, is an uncommon and clinically aggressive malignancy with a uniformly fatal outcome. Three children with newly diagnosed trilateral retinoblastoma were treated ... Full text Link to item Cite

Endobronchial interstitial Au-198 implantation in the treatment of recurrent bronchogenic carcinoma.

Journal Article J Surg Oncol · April 1992 Nineteen patients with non-small-cell bronchogenic carcinoma, recurrent following initial conventional external beam radiotherapy, were treated with endobronchial implantation of Au-198 seeds. Seventeen patients were symptomatic with primary symptoms of pe ... Full text Link to item Cite

Medical oaths.

Journal Article Acad Med · April 1992 Full text Link to item Cite

Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx.

Journal Article Cancer · March 15, 1992 A patient with a primary undifferentiated carcinoma of the nasopharynx manifested the clinical syndrome of inappropriate antidiuretic hormone secretion (SIADH). Immunohistochemical techniques demonstrated the presence of vasopressin, neurophysin, and their ... Full text Link to item Cite

Influence of coralline hydroxyapatite used as an ocular implant on the dose distribution of external beam photon radiation therapy.

Journal Article Ophthalmology · March 1992 Coralline hydroxyapatite spheres are used as buried integrated ocular implants after enucleation or evisceration surgery. Because such implants are used after surgery for intraocular malignancy and because some patients may require postoperative radiation ... Full text Link to item Cite

Post-mastectomy radiotherapy following adjuvant chemotherapy and autologous bone marrow transplantation for breast cancer patients with greater than or equal to 10 positive axillary lymph nodes. Cancer and Leukemia Group B.

Journal Article Int J Radiat Oncol Biol Phys · 1992 Between 2/87 and 2/91, 49 women with operable breast cancer involving greater than or equal to 10 axillary nodes were treated following mastectomy, with four cycles of Cyclophosphamide, Adriamycin, 5FU, followed by high doses of Cyclophosphamide, Cisplatin ... Full text Link to item Cite

Interspecies cytogenetic comparisons: studies with X-radiation and bleomycin sulfate.

Journal Article Environ Mol Mutagen · 1992 A series of in vitro experiments were conducted to determine if there are innate differences in the sensitivity of peripheral blood lymphocytes (PBLs) from different mammalian species to clastogens. Mouse, rat, and human whole blood samples were exposed to ... Full text Link to item Cite

Supratentorial malignant glioma: patterns of recurrence and implications for external beam local treatment.

Journal Article Int J Radiat Oncol Biol Phys · 1992 Pre- and postoperative computerized tomography scans, simulator films, and computerized tomography scans documenting tumor recurrence were analyzed on 70 patients with supratentorial malignant glioma treated with whole brain plus boost radiation therapy to ... Full text Link to item Cite

FDG-PET in pediatric posterior fossa brain tumors.

Journal Article J Comput Assist Tomogr · 1992 Seventeen pediatric patients with posterior fossa brain tumors were studied with 2-[18F]fluoro-2-deoxy-D-glucose (FDG) and positron emission tomography (PET). The FDG uptake was ranked by two observers, and the results were correlated with tumor histology. ... Full text Link to item Cite

Subfrontal recurrence of medulloblastoma.

Journal Article AJNR Am J Neuroradiol · 1992 Link to item Cite

The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine.

Journal Article Int J Radiat Oncol Biol Phys · 1992 We have used an extensively characterized human glioma cell line in an athymic mouse model to evaluate new therapeutic approaches for human supratentorial high grade gliomas. The tumor, D-54MG, is a subline of a human anaplastic glioma. Eight days after ho ... Full text Link to item Cite

A groundless hypothesis, megaloblastic madness, and the founding of Duke University.

Journal Article Med Hypotheses · November 1991 In a recent issue of Medical Hypotheses, Dr H L Newbold repeats the assertion that the cause of James B Duke's death in 1925 was pernicious anemia. Dr Newbold postulates that Mr Duke was neurologically impaired as a result of vitamin B-12 deficiency and th ... Full text Link to item Cite

Induction of micronuclei by X-radiation in human, mouse and rat peripheral blood lymphocytes.

Journal Article Mutat Res · October 1991 We compared the radiosensitivity of human, rat and mouse peripheral blood lymphocytes (PBLs) by analyzing micronuclei (MN) in cytochalasin B-induced binucleated (BN) cells. For each species and dose 4-ml aliquots of whole blood were X-irradiated to obtain ... Full text Link to item Cite

Hyperfractionated radiation therapy in brain stem tumors. Results of treatment at the 7020 cGy dose level of Pediatric Oncology Group study #8495.

Journal Article Cancer · August 1, 1991 Between May 1986 and February 1988, 57 patients were accrued to the second dose level of a Phase I/II Pediatric Oncology Group (POG) study exploring the use of hyperfractionated radiation therapy (HRT) in children with high-risk brain stem tumors. Local fi ... Full text Link to item Cite

The effect of total-body irradiation on corneal neovascularization in the Fischer 344 rat after chemical cauterization.

Journal Article Invest Ophthalmol Vis Sci · June 1991 Previous investigations of corneal neovascularization after irradiation yielded discordant results. Most studies indicated that new blood vessel formation in the cornea is inhibited by irradiation. However, others reported that angiogenesis after corneal c ... Link to item Cite

Suspicionless drug testing of physicians.

Journal Article N C Med J · April 1991 Link to item Cite

Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma.

Journal Article Med Pediatr Oncol · 1991 Two patients with brain stem gliomas were treated with hyperfractionated radiation therapy (HFR) (7,020 and 7,560 cGy, respectively). Despite initial clinical improvement during irradiation, both patients demonstrated clinical deterioration approximately 3 ... Full text Link to item Cite

High-dose areas are unintentionally created as a result of gap shifts when the prescribed dose in the two adjacent areas are different.

Journal Article Med Dosim · December 1990 A large number of methods have been described for matching adjacent fields to prevent over- or underdosage at a field junction. Most authors recommend that the location of field junctions be shifted to different locations during the course of the treatment ... Full text Link to item Cite

The persistence of lymphocytes with dicentric chromosomes following whole-body X irradiation of mice.

Journal Article Radiat Res · October 1990 Thirty-six male C57B1/6 mice were X-irradiated whole body with 3 Gy to generate lymphocytes with dicentric chromosomes to study the persistence of these lymphocytes in the spleen and peripheral blood to estimate the life span of mature B- and T-cells. Peri ... Link to item Cite

Doublespeak in high places.

Journal Article N C Med J · August 1990 Link to item Cite

Effects of hyperthermia and irradiation on the growth of mouse melanoma tumors following immunotherapy.

Journal Article J Surg Oncol · August 1990 Recent investigations suggest that adjuvant hyperthermia enhances the response of human malignant melanoma to ionizing radiation. A study was undertaken to explore the effect of radiation and hyperthermia on the responsiveness of melanoma following active ... Full text Link to item Cite

Irradiation for xenogeneic transplantation.

Journal Article Radiother Oncol · May 1990 Xenogeneic transplantation (XT) is the transplantation of organs or tissues from a member of one species to a member of another. Mammalian species frequently have circulating antibody which is directed against the foreign organ irrespective of known prior ... Full text Link to item Cite

L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice.

Journal Article Neurosurgery · February 1990 An intracranial (i.c.) interstitial radiotherapy model in athymic nude mice bearing i.c. D-54 MG human glioma xenografts was developed, allowing evaluation of the therapeutic benefits seen after L-buthionine-S,R-sulfoximine (L-BSO)-mediated depletion of tu ... Full text Link to item Cite

The North Carolina Medical Journal and its peers.

Journal Article N C Med J · January 1990 Link to item Cite

Significant prolongation of hamster liver transplant survival in Lewis rats by total-lymphoid irradiation, cyclosporine, and splenectomy.

Journal Article Transplantation · January 1990 The effects of total lymphoid irradiation, cyclosporine and splenectomy alone and in combination have been studied in liver transplants from the LVG hamster to the LEW rat. Neither CsA alone, splenectomy alone, nor TLI alone prolonged graft survival. CsA/s ... Full text Link to item Cite

Radiation therapy treatment planning in supratentorial glioblastoma multiforme: an analysis based on post mortem topographic anatomy with CT correlations.

Journal Article Int J Radiat Oncol Biol Phys · December 1989 In a previous study of the brains of 15 adults with glioblastoma multiforme who received minimal or no radiotherapy we determined the topographic distribution of tumor cells. All 15 brains had been fixed and then cut in the coronal or horizontal plane. The ... Full text Link to item Cite

Reducing infant mortality in North Carolina.

Journal Article N C Med J · August 1989 Link to item Cite

Phase II treatment of medulloblastoma and pineoblastoma with melphalan: clinical therapy based on experimental models of human medulloblastoma.

Journal Article J Clin Oncol · July 1989 We conducted a phase II study of intravenous (IV) melphalan in the treatment of children with recurrent medulloblastoma and in the initial treatment of children with poor-prognosis medulloblastoma and pineoblastoma. There was one complete response (CR) and ... Full text Link to item Cite

Consent for a minor's abortion.

Journal Article N C Med J · April 1989 Link to item Cite

The effects of total lymphoid irradiation upon corneal vascularization in the rat following chemical cautery.

Journal Article Radiat Res · February 1989 The effect of total lymphoid irradiation (TLI), a form of radiotherapy known to suppress the number of circulating lymphocytes, on corneal neovascularization was assessed in rats. The corneas of TLI-treated rats were cauterized with silver/potassium nitrat ... Link to item Cite

Micronuclei in binucleated lymphocytes of mice following exposure to gamma radiation.

Journal Article Environ Mol Mutagen · 1989 Experiments were designed to investigate the induction of micronuclei (MN) in mouse peripheral blood lymphocytes (PBLs) after in vitro or in vivo exposure to 60Co gamma radiation. For the in vitro experiments, 4 ml of blood from male C57BL/6J mice were eit ... Full text Link to item Cite

Criteria for termination of phase II chemotherapy for patients with progressive or recurrent brain tumor.

Journal Article Neurology · January 1989 We report six patients with progressive primary tumors of the brain who had prolonged periods with stable contrast-enhancing CT lesions following initial responses to chemotherapy. Chemotherapy was discontinued after 21 to 36 months, despite the persistenc ... Full text Link to item Cite

Selection of a management strategy for pediatric brainstem tumors.

Journal Article Med Pediatr Oncol · 1989 Brainstem tumors arise in portions of the rhombencephalon and mesencephalon. Some authorities include diencephalic tumors in this group. We have reviewed our clinical experience of 69 children (less than 21 years of age) with brainstem tumors evaluated and ... Full text Link to item Cite

The right to privacy and the duty to protect.

Journal Article South Med J · October 1988 Full text Link to item Cite

The role of irradiation in solid organ transplantation.

Journal Article Int J Radiat Oncol Biol Phys · October 1988 Full text Link to item Cite

The audition elective.

Journal Article Int J Radiat Oncol Biol Phys · September 1988 Full text Link to item Cite

The fallacy of the localized supratentorial malignant glioma.

Journal Article Int J Radiat Oncol Biol Phys · August 1988 Full text Link to item Cite

A cytogenetic comparison of the responses of mouse and human peripheral blood lymphocytes to 60Co gamma radiation.

Journal Article Radiat Res · August 1988 Experiments were conducted to compare the chromosome damaging effects of 60Co gamma radiation on mouse and human peripheral blood lymphocytes (PBLs). Either whole blood or isolated and pelleted mononuclear leucocytes (MNLs) were irradiated with a 60Co unit ... Link to item Cite

X-rays at the bar, 1896-1910.

Journal Article Invest Radiol · August 1988 Full text Link to item Cite

Intracranial atherosclerosis following radiotherapy.

Journal Article Neurology · July 1988 We describe a case of severe intracranial atherosclerosis in a young man who had received therapeutic radiation for a presumed brain neoplasm. Since there was no evidence of vascular disease outside the radiation ports, we speculate that accelerated athero ... Full text Link to item Cite

Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc.

Journal Article Am J Pathol · March 1988 D341 Med is a new continuous cell line and transplantable xenograft derived from a cerebellar medulloblastoma. This line grew in vitro in suspension culture with spontaneous macroscopic spheroid formation and demonstrated 20-fold amplification of c-myc. Cu ... Link to item Cite

Medical origins of Duke University?

Journal Article N C Med J · December 1987 Link to item Cite

Hepatic metastasis from neuroblastoma.

Journal Article South Med J · November 1987 Neuroblastoma is a common solid tumor of infancy and childhood. From 1967 to 1986 we evaluated and treated 58 children with neuroblastoma; in ten (17%) of these children, symptomatic hepatic metastasis developed. The ten children ranged in age from 2 days ... Full text Link to item Cite

Oligodendroglioma. An analysis of the value of radiation therapy.

Journal Article Cancer · November 1, 1987 The role of radiation therapy in the treatment of supratentorial oligodendrogliomas is controversial. To evaluate the role of radiation therapy, the Duke University Medical Center series was retrospectively analyzed. Clinical history, radiation dosages, an ... Full text Link to item Cite

The influence of dose and dose rate of total lymphoid irradiation in the rat cardiac allograft model.

Journal Article Radiother Oncol · August 1987 Immunosuppression generated by total lymphoid irradiation (TLI) may be of use in solid organ transplantation. We have investigated the use of TLI in the rat cardiac allograft model. Lewis rats received TLI from a cobalt-60 machine. The daily dose was 1.25 ... Full text Link to item Cite

Xenograft survival in two species combinations using total-lymphoid irradiation and cyclosporine.

Journal Article Transplantation · February 1987 Total lymphoid irradiation (TLI) has profound immunosuppressive actions and has been applied successfully to allotransplantation but not xenotransplantation. Cyclosporine (CsA) has not generally permitted successful xenotransplantation of organs but has no ... Full text Link to item Cite

Medulloblastoma: the Duke University Medical Center experience.

Journal Article Int J Radiat Oncol Biol Phys · October 1986 We have reviewed the clinical experience in the treatment of medulloblastoma with radiotherapy at Duke University Medical Center. One hundred and twenty-seven patients treated between January 1, 1940 and December 31, 1983 were evaluated. The irradiation te ... Full text Link to item Cite

Radiation therapy in the management of neuroblastoma: the Duke University Medical Center experience 1967-1984.

Journal Article Int J Radiat Oncol Biol Phys · October 1986 We have evaluated the role of radiotherapy in providing local control of primary tumors and to palliate metastases from neuroblastoma (NB). Fifty-five children with histologically verified NB were evaluated and treated from 1967 to 1984. In univariate anal ... Full text Link to item Cite

Pediatric radiation oncology.

Journal Article Invest Radiol · May 1986 Full text Link to item Cite

Prolonged heart xenograft survival using combined total lymphoid irradiation and cyclosporine.

Journal Article J Heart Transplant · 1986 Total lymphoid irradiation and cyclosporine have profound immunosuppressive properties and permit successful heart allotransplantation. Cyclosporine used alone has not permitted consistently successful transplantation between species in all cases. Total ly ... Link to item Cite

Conventional external beam radiotherapy for central nervous system malignancies.

Journal Article Neurol Clin · November 1985 Fractionated external beam photon radiotherapy is an important component of the clinical management of malignant disease of the central nervous system. The practicing neurologist or neurosurgeon frequently relies on the consultative and treatment skills of ... Link to item Cite

Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med.

Journal Article J Neuropathol Exp Neurol · November 1985 A new continuous cell line and transplantable xenograft, D283 Med, was derived from the peritoneal implant and ascitic fluid of a child with metastatic medulloblastoma and grew in vitro in suspension culture with spontaneous macroscopic spheroid formation. ... Full text Link to item Cite

Pediatric brain stem tumors: patterns of treatment failure and their implications for radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · July 1985 There have been conflicting opinions regarding the correct volume to be used in radiotherapy fields for brain stem tumors of childhood. Whereas many clinicians recommend limited fields designed to cover the tumor volume with a margin, some have advocated w ... Full text Link to item Cite

Total lymphoid irradiation as an immunosuppressive agent for transplantation and the treatment of 'autoimmune' disease: a review.

Journal Article Clin Radiol · March 1985 Total lymphoid irradiation (TLI) is a powerful immunosuppressive agent. This immunosuppression has the potential for clinical application in certain selected situations. In this review, the immunological changes produced by TLI and its potential applicatio ... Full text Link to item Cite

The effect of cyclosporine, total lymphoid irradiation, and cobra venom factor on hyperacute rejection.

Journal Article J Heart Transplant · 1985 Transplantation into sensitized recipients is contraindicated due to the potential for hyperacute rejection. In order to study the mechanism of hyperacute rejection and the role of immunosuppression in the face of presensitization, we evaluated the effect ... Link to item Cite

The use of local allograft irradiation following renal transplantation.

Journal Article Int J Radiat Oncol Biol Phys · July 1984 Over a 10 year period, 67 recipients of 71 renal allografts received graft irradiation following the diagnosis of rejection. The majority of kidneys were treated with a total dose of 600 rad, 150 rad per fraction, in 4 daily fractions. Fifty-three kidneys ... Full text Link to item Cite

Sarcoma of bone and soft tissue following treatment of Hodgkin's disease.

Journal Article Cancer · January 15, 1984 Intensive chemotherapy and radiotherapy of Hodgkin's Disease has resulted in improved survival rates. With long-term follow-up, however, a risk of secondary malignancy in these individuals is now appreciated. The authors of this report have encountered fiv ... Full text Link to item Cite

Adrenal insufficiency secondary to metastatic lung carcinoma: CT aided diagnosis.

Journal Article J Comput Assist Tomogr · December 1983 A patient with adenocarcinoma of the lung associated with clinical and laboratory evidence of adrenal insufficiency is described. Bilateral adrenal masses were identified on computed tomography and percutaneous needle biopsy confirmed metastatic adenocarci ... Full text Link to item Cite

The role of radiation therapy in the management of metastatic renal cell carcinoma.

Journal Article Cancer · February 15, 1983 From 1965 to 1980, 35 patients were treated by radiation for palliation of symptoms related to metastatic renal cell carcinoma. The male:female ratio was 1.9:1. Eighty-six percent (30/35) of the patients were over 40 years of age at initial presentation. S ... Full text Link to item Cite

Radiotherapy of polymorphic reticulosis.

Journal Article Br J Radiol · September 1982 The term "lethal mid-line granuloma" does not properly reflect current knowledge that several different diseases can produce non-infectious mid-facial destruction. The disorders producing erosion of the upper aerodigestive passages are more accurately clas ... Full text Link to item Cite

The use of D-penicillamine in cystinuria: efficacy and untoward reactions.

Journal Article Yale J Biol Med · 1981 A retrospective study was conducted to assess the efficacy of D-penicillamine in the management of cystinuria, as well as to define the frequency and nature of untoward reactions to this drug. Fifty-six individuals were identified who, by stone analysis an ... Link to item Cite