Scholars@Duke
Christopher Ritchie Mantyh

Christopher Ritchie Mantyh

Professor of Surgery
Surgical Oncology
christopher.mantyh@duke.edu
Box 3117 Med Ctr, Durham, NC 27710
7676 Hosp North Hafs Building, Durham, NC 27710

Selected Publications

The Uroplastic Approach to Complex Rectourethral Fistula Repair: Indications, Technique, Results.

Journal Article Plast Reconstr Surg Glob Open · April 2025 BACKGROUND: Rectourethral fistulae are complex pathologies with significant morbidity that warrant multidisciplinary care. Although gracilis muscle interposition for fistula repair has been reported, specific indications and techniques for this mode of rec ... Full text Link to item Cite

Perioperative and Oncologic Outcomes of Hepatic Arterial Infusion (HAI) Pump Chemotherapy for Patients with Unresectable Colorectal Liver Metastases at an Expanding HAI Program.

Conference Ann Surg Oncol · February 2025 BACKGROUND: Hepatic arterial infusion (HAI) is an established treatment for patients with unresectable colorectal liver metastases (uCRLM). Until recently, HAI was only performed at a limited number of centers. We previously reported early outcomes suggest ... Full text Link to item Cite

The Role of Sleep Apnea in Postoperative Neurocognitive Disorders Among Older Noncardiac Surgery Patients: A Prospective Cohort Study.

Journal Article Anesth Analg · January 1, 2025 BACKGROUND: Obstructive sleep apnea is associated with increased dementia risk, yet its role in postoperative neurocognitive disorders is unclear. Here, we studied whether the severity of untreated obstructive sleep apnea is associated with the severity of ... Full text Link to item Cite

Social Vulnerability Index and Survivorship after Colorectal Cancer Resection.

Journal Article J Am Coll Surg · April 1, 2024 BACKGROUND: Race and socioeconomic status incompletely identify patients with colorectal cancer (CRC) at the highest risk for screening, treatment, and mortality disparities. Social vulnerability index (SVI) was designed to delineate neighborhoods requirin ... Full text Link to item Cite

The empty pelvis syndrome: a core data set from the PelvEx collaborative.

Journal Article Br J Surg · March 2, 2024 BACKGROUND: Empty pelvis syndrome (EPS) is a significant source of morbidity following pelvic exenteration (PE), but is undefined. EPS outcome reporting and descriptors of radicality of PE are inconsistent; therefore, the best approaches for prevention are ... Full text Link to item Cite

Beating the empty pelvis syndrome: the PelvEx Collaborative core outcome set study protocol.

Journal Article BMJ Open · February 5, 2024 INTRODUCTION: The empty pelvis syndrome is a significant source of morbidity following pelvic exenteration surgery. It remains poorly defined with research in this field being heterogeneous and of low quality. Furthermore, there has been minimal engagement ... Full text Link to item Cite

A Risk-Prediction Platform for Acute Kidney Injury and 30-Day Readmission After Colorectal Surgery.

Journal Article J Surg Res · December 2023 INTRODUCTION: Few known risk factors for certain surgical complications are prospectively analyzed to ascertain their influence on outcomes. Health systems can use integrated machine-learning-derived algorithms to provide information regarding patients' ri ... Full text Link to item Cite

Research Priorities in Prehabilitation for Patients Undergoing Cancer Surgery: An International Delphi Study.

Journal Article Ann Surg Oncol · November 2023 BACKGROUND: Recently, the number of prehabilitation trials has increased significantly. The identification of key research priorities is vital in guiding future research directions. Thus, the aim of this collaborative study was to define key research prior ... Full text Link to item Cite

Outcomes of an Algorithmic, Multidisciplinary Approach to Rectourethral Fistula Repair: A Pre- and Postintervention Quasi-Experimental Study.

Conference Diseases of the colon and rectum · April 2023 BackgroundRectourethral fistulas are a rare yet severe complication of prostate surgery, pelvic irradiation therapy, or both. Multiple surgical repairs exist with widely varying success rates.ObjectiveThis study aimed to present our insti ... Full text Cite

Discussion.

Journal Article J Am Coll Surg · April 1, 2023 Full text Link to item Cite

Closed Incision Negative Pressure Therapy versus Standard of Care in Reduction of Surgical Site Complications: A Systematic Review and Meta-analysis

Journal Article Plastic and Reconstructive Surgery - Global Open · March 16, 2023 Introduction: Closed incision negative pressure therapy (ciNPT) has been utilized to help manage closed incisions across many surgical specialties. This systematic review and meta-analysis evaluated the effect of ciNPT on postsurgical and health economic o ... Full text Cite

Surgical Site Infection Prevention: A Review.

Journal Article JAMA · January 17, 2023 IMPORTANCE: Approximately 0.5% to 3% of patients undergoing surgery will experience infection at or adjacent to the surgical incision site. Compared with patients undergoing surgery who do not have a surgical site infection, those with a surgical site infe ... Full text Link to item Cite

Early recognition and response to increases in surgical site infections using optimised statistical process control charts-The early 2RIS trial: A multicentre stepped wedge cluster randomised controlled trial.

Journal Article EClinicalMedicine · December 2022 BACKGROUND: Traditional approaches for surgical site infection (SSI) surveillance have deficiencies that delay detection of SSI outbreaks and other clinically important increases in SSI rates. We investigated whether use of optimised statistical process co ... Full text Open Access Link to item Cite

Patient-Reported and Physiologic Outcomes Following Pelvic Exenteration for Non-Repairable Radiated Rectourethral Fistula.

Journal Article Urology · August 2022 OBJECTIVE: To investigate the impact of pelvic exenteration (PelvEX) on patient-reported pain, distress, and quality of life along with physiologic indicators of health in cancer survivors with radiated, non-repairable rectourethral fistula (RUF). MATERIAL ... Full text Link to item Cite

Estimation of Surgery Durations Using Machine Learning Methods-A Cross-Country Multi-Site Collaborative Study.

Journal Article Healthcare (Basel) · June 25, 2022 The scheduling of operating room (OR) slots requires the accurate prediction of surgery duration. We evaluated the performance of existing Moving Average (MA) based estimates with novel machine learning (ML)-based models of surgery durations across two sit ... Full text Link to item Cite

Combined Primary Resection with Hepatic Artery Infusion Pump Implantation Is Safe for Unresectable Colorectal Liver Metastases.

Journal Article J Gastrointest Surg · April 2022 BACKGROUND: Colorectal liver metastases (CRLM) are the most common cause of disease-specific mortality in patients with colorectal cancer. Hepatic artery infusion (HAI) combined with systemic chemotherapy improves survival for these patients. The safety of ... Full text Link to item Cite

Contemporary Management of Locally Advanced and Recurrent Rectal Cancer: Views from the PelvEx Collaborative

Journal Article Cancers · March 1, 2022 Pelvic exenteration is a complex operation performed for locally advanced and recurrent pelvic cancers. The goal of surgery is to achieve clear margins, therefore identifying adjacent or involved organs, bone, muscle, nerves and/or vascular structures that ... Full text Cite

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

Journal Article Ann Clin Transl Neurol · February 2022 OBJECTIVE: Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cereb ... Full text Open Access Link to item Cite

Delphi Consensus on Intraoperative Technical/Surgical Aspects to Prevent Surgical Site Infection after Colorectal Surgery.

Journal Article J Am Coll Surg · January 1, 2022 BACKGROUND: Previous studies have focused on the development and evaluation of care bundles to reduce the risk of surgical site infection (SSI) throughout the perioperative period. A focused examination of the technical/surgical aspects of SSI reduction du ... Full text Link to item Cite

Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.

Journal Article Br J Anaesth · December 2021 BACKGROUND: Cognitive dysfunction after surgery is a major issue in older adults. Here, we determined the effect of APOE4 on perioperative neurocognitive function in older patients. METHODS: We enrolled 140 English-speaking patients ≥60 yr old scheduled fo ... Full text Open Access Link to item Cite

Induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as neoadjuvant treatment for locally recurrent rectal cancer: study protocol of a multicentre, open-label, parallel-arms, randomized controlled study (PelvEx II).

Journal Article BJS Open · May 7, 2021 BACKGROUND: A resection with clear margins (R0 resection) is the most important prognostic factor in patients with locally recurrent rectal cancer (LRRC). However, this is achieved in only 60 per cent of patients. The aim of this study is to investigate wh ... Full text Link to item Cite

Does Fragmentation of Care in Locally Advanced Rectal Cancer Increase Patient Mortality?

Journal Article J Gastrointest Surg · May 2021 OBJECTIVE: To evaluate health care fragmentation in patients with stage II and III rectal cancers. BACKGROUND: Fragmentation of care among multiple hospitals may worsen outcomes for cancer patients. METHODS: National Cancer Database was queried for adult p ... Full text Link to item Cite

Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.

Journal Article Sci Rep · February 4, 2021 Arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) derived lipids play key roles in initiating and resolving inflammation. Neuro-inflammation is thought to play a causal role in perioperative neurocognitive disorders, yet th ... Full text Open Access Link to item Cite

Perioperative management and anaesthetic considerations in pelvic exenterations using Delphi methodology: results from the PelvEx Collaborative.

Journal Article BJS Open · January 8, 2021 BACKGROUND: The multidisciplinary perioperative and anaesthetic management of patients undergoing pelvic exenteration is essential for good surgical outcomes. No clear guidelines have been established, and there is wide variation in clinical practice inter ... Full text Link to item Cite

Evolution of minimally invasive surgery for rectal cancer: update from the national cancer database.

Journal Article Surg Endosc · January 2021 BACKGROUND: As the use of minimally invasive techniques in colorectal surgery has become increasingly prevalent, concerns remain about the oncologic effectiveness and long-term outcomes of minimally invasive low anterior resection (MI-LAR) for the treatmen ... Full text Link to item Cite

Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2021 BACKGROUND: Postoperative cognitive dysfunction (POCD), a syndrome of cognitive deficits occurring 1-12 months after surgery primarily in older patients, is associated with poor postoperative outcomes. POCD is hypothesized to result from neuroinflammation; ... Full text Open Access Link to item Cite

Predicting outcomes of pelvic exenteration using machine learning.

Journal Article Colorectal Dis · December 2020 AIM: We aim to compare machine learning with neural network performance in predicting R0 resection (R0), length of stay > 14 days (LOS), major complication rates at 30 days postoperatively (COMP) and survival greater than 1 year (SURV) for patients having ... Full text Link to item Cite

A Precision Medicine Drug Discovery Pipeline Identifies Combined CDK2 and 9 Inhibition as a Novel Therapeutic Strategy in Colorectal Cancer.

Journal Article Mol Cancer Ther · December 2020 Colorectal cancer is the third most common cancer in the United States and responsible for over 50,000 deaths each year. Therapeutic options for advanced colorectal cancer are limited, and there remains an unmet clinical need to identify new treatments for ... Full text Link to item Cite

Simultaneous pelvic exenteration and liver resection for primary rectal cancer with synchronous liver metastases: results from the PelvEx Collaborative.

Journal Article Colorectal Dis · October 2020 AIM: At presentation, 15-20% of patients with rectal cancer already have synchronous liver metastases. The aim of this study was to determine the surgical and survival outcomes in patients with advanced rectal cancer who underwent combined pelvic exenterat ... Full text Link to item Cite

Management strategies for patients with advanced rectal cancer and liver metastases using modified Delphi methodology: results from the PelvEx Collaborative.

Journal Article Colorectal Dis · September 2020 AIM: A total of 15-20% of patients with rectal cancer have liver metastases on presentation. The management of these patients is controversial. Heterogeneity in management strategies is considerable, with management often being dependent on local resources ... Full text Link to item Cite

A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.

Journal Article J Neurol · July 2020 OBJECTIVE: Lumbar punctures (LPs) are important for obtaining CSF in neurology studies but are associated with adverse events and feared by many patients. We determined adverse event rates and pain scores in patients prospectively enrolled in two cohort st ... Full text Link to item Cite

Comparison of survival of stage I-III colon cancer by travel distance and hospital volume.

Journal Article Tech Coloproctol · July 2020 BACKGROUND: Previous studies have demonstrated improved outcomes at high-volume colorectal surgery centers; however, the benefit for patients who live far from such centers has not been assessed relative to local, low-volume facilities. METHODS: The 2010-2 ... Full text Link to item Cite

Roadmap for Transforming Preoperative Assessment to Preoperative Optimization.

Journal Article Anesth Analg · April 2020 Preoperative assessment typically equates to evaluating and accepting the presenting condition of the patient (unless extreme) and commonly occurs only a few days before the planned surgery. While this timing enables a preoperative history and examination ... Full text Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.

Journal Article Anesth Analg · November 2019 Animal models suggest postoperative cognitive dysfunction may be caused by brain monocyte influx. To study this in humans, we developed a flow cytometry panel to profile cerebrospinal fluid (CSF) samples collected before and after major noncardiac surgery ... Full text Open Access Link to item Cite

Disparity of Colon Cancer Outcomes in Rural America: Making the Case to Travel the Extra Mile.

Journal Article J Gastrointest Surg · November 2019 OBJECTIVES: Rural patients experience disparities in cancer care compared to urban patients. We hypothesized that rural patients with colon cancer who traveled to high-volume centers for treatment have similar survival compared to urban patients who also t ... Full text Link to item Cite

Palliative pelvic exenteration: A systematic review of patient-centered outcomes.

Journal Article European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · October 2019 ObjectivePalliative pelvic exenteration (PPE) is a technically complex operation with high morbidity and mortality rates, considered in patients with limited life expectancy. There is little evidence to guide practice. We performed a systematic re ... Full text Cite

Association between Survival and Fragmented Care in Stage II and III Rectal Cancer

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · October 1, 2019 Link to item Cite

Adjuvant Chemotherapy Improves Survival Following Resection of Locally Advanced Rectal Cancer with Pathologic Complete Response.

Conference J Gastrointest Surg · August 2019 BACKGROUND: Controversy exists over the use of adjuvant chemotherapy for locally advanced (stages II-III) rectal cancer (LARC) patients who demonstrate pathologic complete response (pCR) following neoadjuvant chemoradiation. We conducted a retrospective an ... Full text Link to item Cite

The side of the primary tumor affects overall survival in colon adenocarcinoma: an analysis of the national cancer database.

Journal Article Tech Coloproctol · June 2019 BACKGROUND: Due to conflicting study results on the effect of laterality on overall survival in primary colon cancers, we sought to examine the impact of left compared to right-sided primary tumors on overall survival for stage I-III colon cancer using the ... Full text Link to item Cite

Disparities in colostomy reversal after Hartmann's procedure for diverticulitis.

Journal Article Tech Coloproctol · May 2019 BACKGROUND: Hartmann's procedure for diverticulitis is a common procedure, with highly variable rates and timing of colostomy reversal. The aim of this study was to evaluate the impact of race and insurance coverage on reversal within 2 years of Hartmann's ... Full text Link to item Cite

Multidisciplinary Approach to Clostridium difficile Infection in Adult Surgical Patients.

Journal Article J Am Coll Surg · April 2019 BACKGROUND: In 2017, our hospital was identified as a high outlier for postoperative Clostridium difficile infections (CDIs) in the American College of Surgeons NSQIP semi-annual report. The Department of Surgery initiated a CDI task force with representat ... Full text Link to item Cite

Modified V-Y Fasciocutaneous Flap Reconstruction After Abdominoperineal Resection in Irradiated Patients Prevents Wound Dehiscence and Associated Complications: A Retrospective Analysis and Benchtop Confirmation.

Journal Article Ann Plast Surg · February 2019 BACKGROUND: Primary perineal closure following abdominal perineal resection (APR) is reported to have a wound complication rate as high as 66%, whereas flap reconstruction reduces wound complications to 15% to 35%. A modified de-epithelialized V-Y fasciocu ... Full text Link to item Cite

With widespread adoption of MIS colectomy for colon cancer, does hospital type matter?

Journal Article Surg Endosc · January 2019 BACKGROUND: Recent studies have shown that hospital type impacts patient outcomes, but no studies have examined hospital differences in outcomes for patients undergoing minimally invasive surgery (MIS) for segmental colectomies. METHODS: The 2010-2014 Nati ... Full text Link to item Cite

Impact of Disgust on Intentions to Undergo Colorectal Surgery.

Journal Article Dis Colon Rectum · December 2018 BACKGROUND: Surgeons present patients with complex information at the perioperative appointment. Emotions likely play a role in surgical decision-making, and disgust is an emotion of revulsion at a stimulus that can lead to avoidance. OBJECTIVE: The purpos ... Full text Link to item Cite

Local excision results in comparable survival to radical resection for early-stage rectal carcinoid.

Journal Article J Surg Res · October 2018 BACKGROUND: Controversy exists regarding current National Comprehensive Cancer Network guidelines, which recommend local excision for rectal carcinoids ≤2 cm and radical resection for tumors >2 cm. Given the limited data examining optimal surgical approach ... Full text Link to item Cite

Resected irradiated rectal cancers: Are twelve lymph nodes really necessary in the era of neoadjuvant therapy?

Conference Am J Surg · September 2018 BACKGROUND: Our study aims to identify the minimum number of lymph nodes (LN) associated with improved survival in patients who underwent NRT for stage II-III rectal cancer. METHODS: Adults with clinical stage II and III rectal adenocarcinoma in the Nation ... Full text Link to item Cite

Response to Mroczkowski.

Journal Article Colorectal Dis · May 2018 Full text Link to item Cite

Response to Letter to the Editor.

Journal Article Dis Colon Rectum · May 2018 Full text Link to item Cite

Flap repair of complex pilonidal sinus: a single institution experience

Journal Article European Journal of Plastic Surgery · April 1, 2018 Background: Healing of pilonidal cysts after initial excision remains a vexing problem for surgeons. While simple sinus can be managed with success, recurrence of the cyst after primary excision or sizeable sinus often requires a more complex repair; howev ... Full text Cite

Delay in Adjuvant Chemotherapy and Survival Advantage in Stage III Colon Cancer.

Journal Article J Am Coll Surg · April 2018 BACKGROUND: Adjuvant chemotherapy after resection is the standard of care for stage III colon cancer, yet many patients omit chemotherapy. We aimed to describe the impact of delayed chemotherapy on overall survival across multiple time points. STUDY DESIGN ... Full text Link to item Cite

The appropriateness of 30-day mortality as a quality metric in colorectal cancer surgery.

Journal Article Am J Surg · January 2018 BACKGROUND: Our study compares 30-day vs. 90-day mortality following colorectal cancer surgery (CRS), and examines hospital performance ranking based on this assessment. METHODS: Mortality rates were compared between 30 vs. 90 days following CRS for patien ... Full text Link to item Cite

Association between neoadjuvant chemoradiation and survival for patients with locally advanced rectal cancer.

Journal Article Colorectal Dis · December 2017 AIM: To examine the overall survival differences for the following neoadjuvant therapy modalities - no therapy, chemotherapy alone, radiation alone and chemoradiation - in a large cohort of patients with locally advanced rectal cancer. METHOD: Adults with ... Full text Link to item Cite

Adjuvant Chemotherapy After Preoperative Chemoradiation Improves Survival in Patients With Locally Advanced Rectal Cancer.

Journal Article Dis Colon Rectum · October 2017 BACKGROUND: Practice guidelines differ in their support of adjuvant chemotherapy use in patients who received preoperative chemoradiation for rectal cancer. OBJECTIVE: The purpose of this study was to evaluate the impact of adjuvant chemotherapy among pati ... Full text Link to item Cite

Association Between Incomplete Neoadjuvant Radiotherapy and Survival for Patients With Locally Advanced Rectal Cancer.

Journal Article JAMA Surg · June 1, 2017 IMPORTANCE: Failing to complete chemotherapy adversely affects survival in patients with colorectal cancer. However, the effect of incomplete delivery of neoadjuvant radiotherapy is unclear. OBJECTIVE: To determine whether incomplete radiotherapy delivery ... Full text Link to item Cite

How Can We Effectively Address the Medical and Psychological Concerns of Survivors of Pelvic Malignancies?

Journal Article Oncology (Williston Park) · April 15, 2017 Sexual and urinary morbidities resulting from treatment of pelvic malignancies are common. These treatment sequelae are significantly bothersome to patients and challenging to address. Awareness of these complications is critical in order to properly couns ... Link to item Cite

Insurance Status, Not Race, is Associated With Use of Minimally Invasive Surgical Approach for Rectal Cancer.

Journal Article Ann Surg · April 2017 OBJECTIVE: To determine the impact of race and insurance on use of minimally invasive (MIS) compared with open techniques for rectal cancer in the United States. BACKGROUND: Race and socioeconomic status have been implicated in disparities of rectal cancer ... Full text Link to item Cite

Hand-Assisted Laparoscopic Colectomy Improves Perioperative Outcomes Without Increasing Operative Time Compared to the Open Approach: a National Analysis of 8791 Patients.

Journal Article J Gastrointest Surg · April 2017 INTRODUCTION: Hand-assisted laparoscopic surgery (HALS) is often used in procedures too complex for completely minimally invasive approaches. However, there are concerns for whether this hybrid approach abrogates perioperative benefits of the completely mi ... Full text Link to item Cite

Determining the Optimal Quantitative Threshold for Preoperative Albumin Level Before Elective Colorectal Surgery.

Journal Article J Gastrointest Surg · April 2017 BACKGROUND: Hypoalbuminemia is associated with adverse surgical outcomes. A minimum threshold and the impact of incrementally decreasing albumin remain undefined for colorectal surgery patients. STUDY DESIGN: The 2011-2013 National Surgical Quality Improve ... Full text Link to item Cite

Minimizing hair dispersal: Is this an opportunity for improvement in health care-acquired infection prevention?

Journal Article Am J Infect Control · March 1, 2017 We performed a study to understand common practices in surgical site hair removal and barriers to guideline compliance in surgical site hair removal. We found most health care providers in the United States do not remove hair outside of the operating room. ... Full text Link to item Cite

V-Y fasciocutaneous flap closure technique is a safe and efficacious alternative to primary closure of the perineal wound following abdominoperineal resection.

Journal Article Am J Surg · February 2017 BACKGROUND: The aim of this study was to compare wound complications from V-Y flap vs primary closure in the setting of abdominoperineal resection. METHODS: This was a single institution retrospective review (1999-2014). The main outcome measures were any ... Full text Link to item Cite

Intensity-Modulated Radiation Therapy Is Not Associated with Perioperative or Survival Benefit over 3D-Conformal Radiotherapy for Rectal Cancer.

Journal Article J Gastrointest Surg · January 2017 INTRODUCTION: The use of intensity-modulated radiation therapy (IMRT) in rectal cancer has steadily increased over traditional 3D conformal radiotherapy (3D-CRT) due to perceived benefit of delivering higher treatment doses while minimizing exposure to sur ... Full text Link to item Cite

Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.

Journal Article Front Syst Neurosci · 2017 Each year over 16 million older Americans undergo general anesthesia for surgery, and up to 40% develop postoperative delirium and/or cognitive dysfunction (POCD). Delirium and POCD are each associated with decreased quality of life, early retirement, incr ... Full text Open Access Link to item Cite

Hand-Assisted Laparoscopic Versus Standard Laparoscopic Colectomy: Are Outcomes and Operative Time Different?

Journal Article J Gastrointest Surg · November 2016 BACKGROUND: HAL colectomy is a technique perceived to provide the benefits of laparoscopic surgery while improving tactile feedback and operative time. Published data are largely limited to small, single-institution studies. METHODS: The 2012-2013 National ... Full text Link to item Cite

Message Framing and Physical Activity Promotion in Colorectal Cancer Survivors.

Journal Article Oncol Nurs Forum · November 1, 2016 PURPOSE/OBJECTIVES: To test effects of gain-framed versus loss-framed mailed brochures on increasing physical activity (PA) among colorectal cancer (CRC) survivors.
. DESIGN: Randomized trial with repeated measures at baseline, 1 month, and 12 months posti ... Full text Link to item Cite

Robotic-Assisted Versus Laparoscopic Colectomy Results in Increased Operative Time Without Improved Perioperative Outcomes.

Journal Article J Gastrointest Surg · August 2016 BACKGROUND: Interest in robotic technology is burgeoning within the field of colorectal surgery. However, benefits of robotic-assisted colectomy (RAC) compared with laparoscopic colectomy (LC) remain ambiguous. STUDY DESIGN: Patients who underwent minimall ... Full text Link to item Cite

Alvimopan Provides Additional Improvement in Outcomes and Cost Savings in Enhanced Recovery Colorectal Surgery.

Conference Ann Surg · July 2016 OBJECTIVE: To examine the impact of alvimopan on outcomes and costs in a rigorous enhanced recovery colorectal surgery protocol. BACKGROUND: Postoperative ileus remains a major source of morbidity and costs in colorectal surgery. Alvimopan has been shown t ... Full text Link to item Cite

Minimally Invasive Versus Open Low Anterior Resection: Equivalent Survival in a National Analysis of 14,033 Patients With Rectal Cancer.

Journal Article Ann Surg · June 2016 OBJECTIVE: To examine survival of patients who underwent minimally invasive versus open low anterior resection (LAR) for rectal cancer. BACKGROUND: Utilization of laparoscopic and robotic LAR for rectal cancer has steadily increased. Short-term outcomes be ... Full text Link to item Cite

Urinary Dysfunction in the Rectal Cancer Survivor

Journal Article Current Bladder Dysfunction Reports · June 1, 2016 Improvements in diagnosis and treatment have resulted in significant improvement in survival rates for rectal cancer. This has led to increasing focus on post-treatment quality of life. One common sequela of treatment for rectal cancer is urinary dysfuncti ... Full text Cite

Does Conversion in Laparoscopic Colectomy Portend an Inferior Oncologic Outcome? Results from 104,400 Patients.

Journal Article J Gastrointest Surg · May 2016 BACKGROUND: Limited data exist regarding the effect of conversion from laparoscopic to open colectomy on perioperative and oncologic outcomes in colon cancer. STUDY DESIGN: The National Cancer Data Base was used to identify patients who underwent colectomy ... Full text Link to item Cite

Optimal Timing to Surgery after Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer.

Journal Article J Am Coll Surg · April 2016 BACKGROUND: Neoadjuvant chemoradiotherapy (nCRT) has demonstrated proven benefit in tumor regression and improved long-term local control for patients with locally advanced rectal cancer. However, precise analysis of the optimal waiting time that maximizes ... Full text Link to item Cite

Surgical Resection of the Primary Tumor in Stage IV Colorectal Cancer Without Metastasectomy is Associated With Improved Overall Survival Compared With Chemotherapy/Radiation Therapy Alone.

Journal Article Dis Colon Rectum · April 2016 BACKGROUND: Controversy exists over whether resection of the primary tumor in stage IV colorectal cancer with inoperable metastases improves patient outcomes. OBJECTIVE: The purpose of this study was to evaluate whether resection of the primary tumor witho ... Full text Link to item Cite

Determining the Optimal Timing for Initiation of Adjuvant Chemotherapy After Resection for Stage II and III Colon Cancer.

Journal Article Dis Colon Rectum · February 2016 BACKGROUND: Several reports suggest that the efficacy of adjuvant chemotherapy on survival diminishes over time for colon cancer; however, precise timing of its loss of benefit has not been established. OBJECTIVE: This study aimed to determine the relation ... Full text Link to item Cite

Effect of combined neoadjuvant chemoradiation on overall survival for patients with locally advanced rectal cancer.

Conference Journal of Clinical Oncology · February 1, 2016 657 Background: Prospective randomized trials have demonstrated that neoadjuvant chemoradiation improves local control and results in a higher rate of sphincter-sparing surgery for patients with locally advanced rectal cancer. Ho ... Full text Cite

Colonic arteriovenous malformations

Chapter · January 1, 2016 Arteriovenous malformations are degenerative vascular lesions of the gastrointestinal tract that result in lower gastrointestinal bleeding, especially in the elderly. Although self-limiting in most cases, symptomatic arteriovenous malformations can present ... Full text Cite

Robotic Low Anterior Resection for Rectal Cancer: A National Perspective on Short-term Oncologic Outcomes.

Journal Article Ann Surg · December 2015 OBJECTIVE: This study examines short-term outcomes and pathologic surrogates of oncologic results among patients undergoing robotic versus laparoscopic low anterior resection for rectal cancer. A total of 6403 patients met inclusion criteria. Although the ... Full text Link to item Cite

Combined Mechanical and Oral Antibiotic Bowel Preparation Reduces Incisional Surgical Site Infection and Anastomotic Leak Rates After Elective Colorectal Resection: An Analysis of Colectomy-Targeted ACS NSQIP.

Journal Article Ann Surg · August 2015 OBJECTIVE: To determine the association between preoperative bowel preparation and 30-day outcomes after elective colorectal resection. METHODS: Patients from the 2012 Colectomy-Targeted American College of Surgeons National Surgical Quality Improvement Pr ... Full text Link to item Cite

Improving Outcomes in Colorectal Surgery by Sequential Implementation of Multiple Standardized Care Programs.

Journal Article J Am Coll Surg · August 2015 BACKGROUND: The purpose of this study was to examine the impact of the sequential implementation of the enhanced recovery program (ERP) and surgical site infection bundle (SSIB) on short-term outcomes in colorectal surgery (CRS) to determine if the presenc ... Full text Open Access Link to item Cite

Metastatic gallbladder cancer masquerading as primary colon malignancy.

Journal Article Clinical Medicine Review Case Reports · June 1, 2015 Cite

Wound classification reporting in HPB surgery: can a single word change public perception of institutional performance?

Journal Article HPB (Oxford) · December 2014 INTRODUCTION: The drive to improve outcomes and the inevitability of mandated public reporting necessitate uniform documentation and accurate databases. The reporting of wound classification in patients undergoing hepato-pancreatico-biliary (HPB) surgery a ... Full text Link to item Cite

Adjuvant chemotherapy for t1 node-positive colon cancers provides significant survival benefit.

Journal Article Dis Colon Rectum · December 2014 BACKGROUND: Contemporary treatment of node-positive (N+) colon cancer consists of adjuvant chemotherapy; however, randomized data supporting this practice were derived from lesions T2 or greater. Minimal data exist regarding the use and need for adjuvant c ... Full text Link to item Cite

A modified bipedicle VRAM flap for simultaneous reconstruction of a perineal and posterior vaginal defect

Journal Article Gynakologe · October 14, 2014 The management of locally advanced pelvic tumors regularly requires radical surgical resection. The resection results in significant intrinsic and extrinsic pelvic defects. The advent of composite flaps has revolutionized vaginal and perineal reconstructio ... Full text Cite

The preventive surgical site infection bundle in colorectal surgery: an effective approach to surgical site infection reduction and health care cost savings.

Journal Article JAMA Surg · October 2014 IMPORTANCE: Surgical site infections (SSIs) in colorectal surgery are associated with increased morbidity and health care costs. OBJECTIVE: To determine the effect of a preventive SSI bundle (hereafter bundle) on SSI rates and costs in colorectal surgery. ... Full text Link to item Cite

Surgical management of complex rectourethral fistulas in irradiated and nonirradiated patients.

Journal Article Dis Colon Rectum · September 2014 BACKGROUND: Rectourethral fistulas are an uncommon, yet devastating occurrence after treatment for prostate cancer or trauma, and their surgical management has historically been nonstandardized. Anecdotally, irradiated rectourethral fistulas portend a wors ... Full text Link to item Cite

Rectourethral fistulas in the cancer survivor.

Journal Article Curr Opin Urol · July 2014 PURPOSE OF REVIEW: Iatrogenic rectourethral fistulas (RUFs) are a rare but challenging complication that can follow the treatment of prostate cancer. We review the literature regarding the surgical management of RUFs and subsequent outcomes, focusing on a ... Full text Link to item Cite

Discrete improvement in racial disparity in survival among patients with stage IV colorectal cancer: a 21-year population-based analysis.

Journal Article J Gastrointest Surg · June 2014 PURPOSE: Recently, multiple clinical trials have demonstrated improved outcomes in patients with metastatic colorectal cancer. This study investigated if the improved survival is race dependent. PATIENTS AND METHODS: Overall and cancer-specific survival of ... Full text Link to item Cite

Reduced length of hospital stay in colorectal surgery after implementation of an enhanced recovery protocol.

Journal Article Anesth Analg · May 2014 BACKGROUND: Enhanced recovery after surgery (ERAS) is a multimodal approach to perioperative care that combines a range of interventions to enable early mobilization and feeding after surgery. We investigated the feasibility, clinical effectiveness, and co ... Full text Open Access Link to item Cite

A simple scoring system for risk-stratifying rectal cancer patients prior to radical resection.

Journal Article Tech Coloproctol · May 2014 BACKGROUND: Various predictors of perioperative risk for patients with rectal cancer undergoing radical resection have been well described, but no simple scoring system for surgeons to estimate this risk currently exists. The objective of this study was to ... Full text Link to item Cite

The impact of laparoscopic versus open approach on reoperation rate after segmental colectomy: a propensity analysis.

Journal Article J Gastrointest Surg · February 2014 BACKGROUND: Reoperation rate has not been well studied as a primary outcome when comparing laparoscopic with open approaches for colorectal resection. The goal of this study was to determine the impact of a laparoscopic approach on rate of reoperation afte ... Full text Link to item Cite

A molecular profile of colorectal cancer to guide prognosis and therapy after resection of primary or metastatic disease.

Conference Journal of Clinical Oncology · February 1, 2013 339 Background: Biomarkers used to identify patients at high risk for recurrence after surgical resection of colorectal cancer (CRC) lack predictive capacity and are applicable only to localized disease. As the use of adjuvant th ... Full text Cite

Survival trends of 89,543 patients with metastatic colorectal cancer: A population-based analysis.

Conference Journal of Clinical Oncology · February 1, 2013 476 Background: Metastatic colorectal cancer remains among the most common causes for cancer death and is a major public health problem. While overall survival improvements have been achieved in clinical trials, it is unknown how ... Full text Cite

Minimally invasive surgery for diverticulitis.

Journal Article Tech Coloproctol · February 2013 The realm of minimally invasive surgery now encompasses the majority of abdominal operations in the field of colorectal surgery. Diverticulitis, a common pathology seen in most colorectal practices, poses unique challenges to surgeons implementing laparosc ... Full text Link to item Cite

Laparoscopic versus open Hartmann procedure for the emergency treatment of diverticulitis: a propensity-matched analysis.

Journal Article Dis Colon Rectum · January 2013 BACKGROUND: A laparoscopic approach has been proposed to reduce the high morbidity and mortality associated with the Hartmann procedure for the emergency treatment of diverticulitis. OBJECTIVE: The objective of our study was to determine whether a laparosc ... Full text Link to item Cite

Is there a role for simultaneous hepatic and colorectal resections? A contemporary view from NSQIP.

Journal Article J Gastrointest Surg · November 2012 INTRODUCTION: The optimal timing of primary and metastatic tumor management in patients with synchronous hepatic colorectal metastases remains controversial. We aimed to compare perioperative outcomes of simultaneous colorectal/liver resection (SCLR) with ... Full text Open Access Link to item Cite

Effect of surgeon specialization on long-term survival following colon cancer resection at an NCI-designated cancer center.

Journal Article J Surg Oncol · September 1, 2012 BACKGROUND: Recent studies have documented improved outcomes for patients undergoing colorectal cancer resection at NCI cancer centers compared to hospitals without this designation. Proposed contributory factors include a higher proportion of surgeons wit ... Full text Link to item Cite

Ex vivo evaluation of preoperatively treated rectal cancer specimens of patients undergoing radical resection.

Journal Article Ann Surg Oncol · June 2012 BACKGROUND: Previous reports have suggested that a subset of patients with advanced rectal cancer that demonstrate minimal or no residual disease after neoadjuvant treatment may either be followed closely or may undergo local resection. We prospectively ev ... Full text Link to item Cite

Bevacizumab-associated fistula formation in postoperative colorectal cancer patients.

Journal Article J Am Coll Surg · April 2012 BACKGROUND: Adjuvant chemotherapy regimens for metastatic colorectal cancer (CRC) routinely include bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor (VEGF). We have identified a correlation between bevacizumab and fistula for ... Full text Link to item Cite

Predictive and prognostic markers of recurrence after resection of primary or metastatic colorectal cancer.

Journal Article Journal of Clinical Oncology · February 1, 2012 447 Background: Current biomarkers for colorectal cancer sub-classify tumors based on single mutations, such as KRAS; however, studies of single mutations belie the molecular complexity of colorectal cancer in which an average of ... Full text Cite

Bevacizumab-Associated Fistula Formation in Postoperative Colorectal Cancer Patients Discussion

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · 2012 Cite

Histological and molecular evaluation of patient-derived colorectal cancer explants.

Journal Article PLoS One · 2012 Mouse models have been developed to investigate colorectal cancer etiology and evaluate new anti-cancer therapies. While genetically engineered and carcinogen-induced mouse models have provided important information with regard to the mechanisms underlying ... Full text Link to item Cite

Detection of intestinal dysplasia using angle-resolved low coherence interferometry.

Journal Article J Biomed Opt · October 2011 Angle-resolved low coherence interferometry (a/LCI) is an optical biopsy technique that allows for depth-resolved, label-free measurement of the average size and optical density of cell nuclei in epithelial tissue to assess the tissue health. a/LCI has pre ... Full text Link to item Cite

Advanced fellowship training is associated with improved lymph node retrieval in colon cancer resections.

Journal Article J Surg Res · September 2011 BACKGROUND: Examination of at least 12 lymph nodes has been established as the standard of care for adequate staging of colon cancer. The purpose of this study was to determine whether surgeon fellowship training, patient body mass index (BMI), and surgica ... Full text Link to item Cite

Complex abdominal wall hernias: a new classification system and approach to management based on review of 133 consecutive patients.

Journal Article Ann Plast Surg · May 2011 BACKGROUND: Plastic surgeons are increasingly involved in the repair of complex ventral hernias. Although this typically involves recurrent incisional hernias, operative strategies can be applied to most abdominal wall defects, including chronic wounds wit ... Full text Link to item Cite

Colonic arteriovenous malformations

Chapter · December 1, 2010 Arteriovenous malformations (also known as angiodysplasias, vascular ectasias, or angiomas) are defined as degenerative lesions of the gastrointestinal tract that result from chronic obstruction of the submucosal veins. Even though the etiology of these le ... Full text Cite

Bleeding colonic tumors

Chapter · December 1, 2010 Bleeding colonic tumors represent one of many causes of lower gastrointestinal bleeding (LGIB) and may present acutely or chronically. The evaluation and management LGIB as a whole is discussed elsewhere in this text. This chapter will focus on the etiolog ... Full text Cite

Abstract LB-213: Plasma soluble VEGFR1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer

Journal Article Cancer Research · April 15, 2010 AbstractWe explored plasma and urinary concentration of four members of the vascular endothelial growth factor (VEGF) family as potential response and toxicity biomarker of bevacizumab with neoadjuvant chemo ... Full text Cite

Abstract LB-76: A study of neoadjuvant bevacizumab with standard chemoradiation versus chemoradiation alone in locally advanced rectal cancer

Conference Cancer Research · April 15, 2010 AbstractThe anti-vascular endothelial growth factor (VEGF) antibody bevacizumab is increasingly being tested with pre-operative (neoadjuvant) regimens in patients with localized cancer, but its effects on me ... Full text Cite

A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer.

Journal Article Oncologist · 2010 INTRODUCTION: Bevacizumab is increasingly being tested with neoadjuvant regimens in patients with localized cancer, but its effects on metastasis and survival remain unknown. This study examines the long-term outcome of clinical stage II/III rectal cancer ... Full text Link to item Cite

Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer.

Journal Article Oncologist · 2010 We explored plasma and urinary concentrations of two members of the vascular endothelial growth factor (VEGF) family and their receptors as potential response and toxicity biomarkers of bevacizumab with neoadjuvant chemoradiation in patients with localized ... Full text Link to item Cite

Neoadjuvant Bevacizumab Does Not Appear to Contribute to Postoperative Complications after Surgery of Rectal Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Neoadjuvant chemoradiation for rectal cancer reduces lymph node harvest in proctectomy specimens.

Journal Article J Gastrointest Surg · February 2009 PURPOSE: The purpose of this study was to compare the number of lymph nodes retrieved following proctectomy for rectal cancer in patients either receiving no neoadjuvant therapy versus those treated with standard preoperative chemoradiation. METHODS: A ret ... Full text Link to item Cite

Extrinsic surgical denervation ameliorates TNBS-induced colitis in rats.

Journal Article Hepatogastroenterology · 2009 BACKGROUND/AIMS: Neurogenic inflammation refers to an inflammatory reflex arc by sensory neurons which transmit nocious stimulus centrally and results in both pain perception and intense local inflammatory reaction. Specific neurons, receptors, and their r ... Link to item Cite

Endogenous ghrelin and 5-HT regulate interdigestive gastrointestinal contractions in conscious rats.

Journal Article Am J Physiol Gastrointest Liver Physiol · August 2008 Endogenous ghrelin causes interdigestive contractions of the stomach in rats. In contrast, previous studies showed that 5-HT(3) and 5-HT(4) receptors were involved in regulating intestinal interdigestive contractions. We studied the possible role of endoge ... Full text Link to item Cite

Routine contrast imaging of low pelvic anastomosis prior to closure of defunctioning ileostomy: is it necessary?

Journal Article J Gastrointest Surg · July 2008 PURPOSE: The purpose of the study was to determine the utility of routine contrast enema prior to ileostomy closure and its impact on patient management in patients with a low pelvic anastomosis. MATERIAL AND METHODS: Two hundred eleven patients had a temp ... Full text Link to item Cite

Does ghrelin explain accelerated gastric emptying in the early stages of diabetes mellitus?

Journal Article Am J Physiol Regul Integr Comp Physiol · June 2008 During the early stages of diabetes, gastric emptying is often accelerated, rather than delayed. The mechanism of accelerated gastric emptying in diabetes has not been fully studied. A recent study showed that plasma ghrelin levels were elevated in diabete ... Full text Link to item Cite

Surgical autonomic denervation results in altered colonic motility: an explanation for low anterior resection syndrome?

Journal Article Surgery · June 2008 BACKGROUND: We hypothesized that the bowel dysfunction known as low anterior resection syndrome is caused by denervation of the left colon. The purpose of this study is to determine how surgical denervation changes left colon motility and to identify the m ... Full text Link to item Cite

Daily intake of high dietary fiber slows accelerated colonic transit induced by restrain stress in rats.

Journal Article Dig Dis Sci · May 2008 BACKGROUND: Stress and central corticotropin releasing factor (CRF) are contributing factors to the pathogenesis of irritable bowel syndrome (IBS). It has been shown that restraint stress and central CRF stimulate colonic motility in rats. Short-chain fatt ... Full text Link to item Cite

Fixed feeding potentiates interdigestive gastric motor activity in rats: importance of eating habits for maintaining interdigestive MMC.

Journal Article Am J Physiol Gastrointest Liver Physiol · March 2008 Endogenous ghrelin regulates the occurrence of interdigestive gastric phase III-like contractions in rats. However, the fasted motor pattern is not as regular and potent in humans and dogs. We hypothesize that eating habits play an important role in mainta ... Full text Link to item Cite

Outcomes Review of Reconstructive Techniques Following Proctectomy

Journal Article Seminars in Colon and Rectal Surgery · March 1, 2008 Surgery continues to be essential in the management of colorectal tumors. For patients with mid and low rectal tumors, sphincter-preserving techniques have become increasingly common and acceptable oncologic results can be achieved. In general, straight co ... Full text Cite

Effects of electroacupuncture on gastric motility and heart rate variability in conscious rats.

Journal Article Auton Neurosci · February 29, 2008 To clarify the mechanism of site-specific effects of acupuncture on gastric motor function, we studied the simultaneous recording of gastric motility and electrocardiogram (ECG) for heart rate variability (HRV) analysis in conscious rats. Gastric motility ... Full text Link to item Cite

Ghrelin accelerates gastric emptying via early manifestation of antro-pyloric coordination in conscious rats.

Journal Article Regul Pept · February 7, 2008 Ghrelin is known to enhance gastric motility and accelerate gastric emptying of liquid and solid food in rats. As solid gastric emptying is regulated by the coordinated motor pattern between the antrum and pylorus (antro-pyloric coordination), we studied t ... Full text Link to item Cite

Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis.

Journal Article Ann Surg Oncol · December 2007 BACKGROUND: The safety of simultaneous resections of colorectal cancer and synchronous liver metastases (SCRLM) is not established. This multi-institutional retrospective study compared postoperative outcomes after simultaneous and staged colorectal and he ... Full text Link to item Cite

Assessing the quality of colorectal cancer care: do we have appropriate quality measures? (A systematic review of literature).

Journal Article J Eval Clin Pract · December 2007 RATIONALE, AIMS AND OBJECTIVES: The burden of illness from colorectal cancer (CRC) can be reduced by improving the quality of care. Identifying appropriate quality measures is the first step in this direction. We identified process measures currently avail ... Full text Link to item Cite

Functional evaluation of the grafted wall with porcine-derived small intestinal submucosa (SIS) to a stomach defect in rats.

Journal Article Surgery · September 2007 BACKGROUND: Small intestinal submucosa (SIS) represents a novel bio-scaffolding material that may be used to repair hollow-organ defects. However, it is unclear whether neurophysiologic responses return to SIS-grafted areas in the gut. We evaluated the fun ... Full text Link to item Cite

Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells.

Journal Article Surgery · August 2007 BACKGROUND: Osteopontin (OPN) mediates cancer metastasis. Mechanisms regulating OPN expression in human colorectal cancer are unknown. Using SW480 colon adenocarcinoma cells, we hypothesized that transcription determines OPN expression. METHODS: SW480 cons ... Full text Link to item Cite

Reconstruction techniques after proctectomy: what's the best?

Journal Article Clin Colon Rectal Surg · August 2007 There are approximately 40,000 new rectal cancer cases diagnosed each year in the United States, representing the second most common gastrointestinal malignancy (behind colon cancer). With the advent of sphincter preserving techniques, patients with mid an ... Full text Link to item Cite

Endogenous acyl ghrelin is involved in mediating spontaneous phase III-like contractions of the rat stomach.

Journal Article Neurogastroenterol Motil · August 2007 In humans and dogs, it is known that motilin regulates phase III contractions of migrating motor complex (MMC) in the fasted state. In rats, however, motilin and its receptor have not been found, and administration of motilin failed to induce any phase III ... Full text Link to item Cite

Invited commentary [1]

Other Diseases of the Colon and Rectum · August 1, 2007 Full text Cite

Luminally released serotonin stimulates colonic motility and accelerates colonic transit in rats.

Journal Article Am J Physiol Regul Integr Comp Physiol · July 2007 Enterochromaffin (EC) cells of the epithelial cells release 5-HT into the lumen, as well as basolateral border. However, the physiological role of released 5-HT into the lumen is poorly understood. Concentrations of 5-HT in the colonic mucosa, colonic lume ... Full text Link to item Cite

Bevacizumab, oxaliplatin, and capecitabine with radiation therapy in rectal cancer: Phase I trial results.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2007 PURPOSE: The overexpression of vascular endothelial growth factor (VEGF) is associated with poor outcomes in colorectal cancer patients. Bevacizumab, a VEGF inhibitor, enhances the effects of chemotherapy and radiation therapy on tumor cytotoxicity in prec ... Full text Link to item Cite

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats.

Journal Article Am J Physiol Gastrointest Liver Physiol · April 2007 Although restraint stress accelerates colonic transit via a central corticotropin-releasing factor (CRF), the precise mechanism still remains unclear. We tested the hypothesis that restraint stress and central CRF stimulate colonic motility and transit via ... Full text Link to item Cite

Fecal pellet output does not always correlate with colonic transit in response to restraint stress and corticotropin-releasing factor in rats.

Journal Article J Gastroenterol · April 2007 BACKGROUND: Fecal pellet output has been assessed as a colonic motor activity because of its simplicity. However, it remains unclear whether an acceleration of colonic transit correlates well with an increase in fecal pellet output. We examined the causal ... Full text Link to item Cite

Quality measures for the use of adjuvant chemotherapy and radiation therapy in patients with colorectal cancer: a systematic review.

Journal Article Cancer · November 15, 2006 BACKGROUND: Chemotherapy (CT) and radiation therapy (RT) are essential components of adjuvant (preoperative or postoperative) therapy for many patients with colorectal cancer (CRC); however, quality measures (QMs) of these critical aspects of CRC treatment ... Full text Link to item Cite

2097

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

The selective mu opioid receptor antagonist, alvimopan, improves delayed GI transit of postoperative ileus in rats.

Journal Article Brain Res · August 2, 2006 Postoperative ileus (POI) is often exacerbated by opioid analgesic use during and following surgery, since mu opioid receptor activation results in a further delay of gastrointestinal (GI) transit. The effects of alvimopan, a novel, selective, and peripher ... Full text Link to item Cite

Quality measures for the diagnosis and management of colorectal cancer.

Journal Article J Clin Oncol · June 20, 2006 16031 Background: The huge burden of illness from colorectal cancer (CRC) can be reduced by improving the quality of care for CRC patients. Identifying appropriate quality measures that can assess the processes of care is the first step in this process. Th ... Link to item Cite

Peripherally administered CRF stimulates colonic motility via central CRF receptors and vagal pathways in conscious rats.

Journal Article Am J Physiol Regul Integr Comp Physiol · June 2006 Corticotropin releasing factor (CRF) is one of the most important factors in the mechanism of stress-induced stimulation of colonic motility. However, it is controversial whether stress-induced stimulation of colonic motility is mediated via central or per ... Full text Link to item Cite

Cancer care quality measures: diagnosis and treatment of colorectal cancer.

Journal Article Evid Rep Technol Assess (Full Rep) · May 2006 OBJECTIVES: To identify measures that are currently available to assess the quality of care provided to patients with colorectal cancer (CRC), and to assess the extent to which these measures have been developed and tested. DATA SOURCES: Published and unpu ... Link to item Cite

The herbal medicine, Dai-Kenchu-to, accelerates delayed gastrointestinal transit after the operation in rats.

Journal Article J Surg Res · April 2006 BACKGROUND: Post-operative ileus (POI) is a transient bowel dysmotility after operation. We have previously shown that laparotomy alone significantly delayed gastrointestinal (GI) transit, compared to anesthesia alone. The GI transit was further delayed af ... Full text Link to item Cite

Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: phase I trial results.

Journal Article J Clin Oncol · February 1, 2006 PURPOSE: Overexpression of epidermal growth factor receptor (EGFR) has been associated with aggressive tumor phenotypes, chemotherapy, and radiation resistance, as well as poor survival in preclinical and clinical models. The EGFR inhibitor gefitinib poten ... Full text Link to item Cite

Comparative analysis of vagotomy and drainage versus vagotomy and resection procedures for bleeding peptic ulcer disease: results of 907 patients from the Department of Veterans Affairs National Surgical Quality Improvement Program database.

Journal Article J Am Coll Surg · January 2006 BACKGROUND: The purpose of this study was to determine postoperative outcomes and risk factors for morbidity and mortality in patients requiring surgery for bleeding peptic ulcer disease (PUD). Vagotomy and drainage procedures are technically simpler but a ... Full text Link to item Cite

Attenuation of acid induced oesophagitis in VR-1 deficient mice.

Journal Article Gut · January 2006 BACKGROUND AND AIMS: Activation of the vanilloid receptor subtype 1 (VR-1) results in release of proinflammatory peptides which initiate an inflammatory cascade known as neurogenic inflammation. We investigated its role in an acute model of surgically indu ... Full text Link to item Cite

Surgical autonomic denervation results in altered colonic motility

Conference DISEASES OF THE COLON & RECTUM · March 1, 2005 Link to item Cite

Inhibition of the vanilloid receptor subtype-1 attenuates TNBS-colitis.

Journal Article J Gastrointest Surg · November 2004 Primary sensory neurons are important in regard to the initiation and propagation of intestinal inflammation. The vanilloid receptor subtype-1 (VR-1) is a cation channel located on the sensory nerves that, when stimulated, release proinflammatory peptides. ... Full text Link to item Cite

Magnitude of abdominal incision affects the duration of postoperative ileus in rats.

Journal Article Surg Endosc · April 2004 BACKGROUND: The pathogenesis of reduced postoperative ileus (POI) in laparoscopic gastrointestinal (GI) surgery still remains controversial. The aim of this study was to investigate the effect of surgical incision on postoperative ileus. METHODS: The effec ... Full text Link to item Cite

A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2004 PURPOSE: Eniluracil, an effective inactivator of dihydropyrimidine dehydrogenase, allows for oral dosing of 5-fluorouracil (5-FU), which avoids the morbidity of continuous infusion 5-FU. We addressed the safety of oral eniluracil and 5-FU combined with pre ... Full text Link to item Cite

Ileal pouch-anal anastomosis for ulcerative colitis and familial adenomatous polyposis: historical development and current status.

Journal Article Ann Surg · December 2003 In summary, the history and development of the proctocolectomy and ileal pouch-anal anastomosis has involved innovative animal and clinical research by several surgical investigators. This evolution followed the classic process of academic surgical progres ... Full text Link to item Cite

Elective stoma construction improves outcomes in medically intractable pressure ulcers.

Journal Article Dis Colon Rectum · November 2003 Featured Publication PURPOSE: Perineal pressure ulcers are a common and devastating complication for paralyzed or chronically bedridden patients. Controversy exists on the benefit of fecal diversion for the treatment and prevention of these ulcers. This study compared outcomes ... Full text Link to item Cite

Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats.

Journal Article Gut · May 2003 Featured Publication BACKGROUND AND AIMS: The role of sensory neurones in colitis was studied by chemical denervation of primary sensory neurones as well as antagonism of the vanilloid receptor-1 (VR-1) in rats prior to administration of dextran sulphate sodium (DSS) to induce ... Full text Link to item Cite

Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats

Journal Article American Journal of Physiology - Regulatory Integrative and Comparative Physiology · May 1, 2003 We studied whether physiological concentration of short-chain fatty acids (SCFAs) affects colonic transit and colonic motility in conscious rats. Intraluminal administration of SCFAs (100-200 mM) into the proximal colon significantly accelerated colonic tr ... Cite

Loop ileostomy closure at an ambulatory surgery facility: a safe and cost-effective alternative to routine hospitalization.

Journal Article Dis Colon Rectum · April 2003 Featured Publication INTRODUCTION: Temporary loop ileostomies have become widely used in colorectal surgery. Subsequent ileostomy closure has traditionally required hospital admission with observation until return of bowel function. On the basis of clinical observation, the au ... Full text Link to item Cite

Preoperative immune status determines anal condyloma recurrence after surgical excision.

Journal Article Dis Colon Rectum · March 2003 Featured Publication PURPOSE: Immunosuppression is an important risk factor for anal condyloma progression; however, its effects on postoperative outcomes remain unclear. In the present study, we investigated risk factors and recurrence rates in immunocompromised patients requ ... Full text Link to item Cite

Evaluation of porcine-derived small intestine submucosa as a biodegradable graft for gastrointestinal healing.

Journal Article J Gastrointest Surg · January 2003 Featured Publication High-risk anastomoses in the gut may benefit from the application of a synthetic reinforcement to prevent an enteric leak. Recently a porcine-derived small intestine submucosa (SIS) was tested as a bioscaffold in a number of organ systems. The aim of this ... Full text Link to item Cite

Complete response to neoadjuvant chemoradiation for rectal cancer does not influence survival.

Journal Article Ann Surg Oncol · December 2001 BACKGROUND: Up to 30% of patients with locally advanced rectal cancer have a complete clinical or pathologic response to neoadjuvant chemoradiation. This study analyzes complete clinical and pathologic responders among a large group of rectal cancer patien ... Full text Link to item Cite

Neoadjuvant chemoradiation for rectal cancer: analysis of clinical outcomes from a 13-year institutional experience.

Journal Article Ann Surg · June 2001 OBJECTIVE: To examine clinical outcomes in patients receiving neoadjuvant chemoradiation for locally advanced rectal adenocarcinoma. SUMMARY BACKGROUND DATA: Preoperative radiation therapy, either alone or in combination with 5-fluorouracil-based chemother ... Full text Link to item Cite

Extrinsic surgical denervation inhibits Clostridium difficile toxin A-induced enteritis in rats.

Journal Article Neurosci Lett · October 6, 2000 Featured Publication Clostridium difficile enteritis is caused by toxin A (TA) which stimulates substance P release and subsequent receptor activation. This receptor stimulation results in secretion, inflammation, and structural damage. However, it is unclear as to which subse ... Full text Link to item Cite

Colonic "coloplasty": novel technique to enhance low colorectal or coloanal anastomosis.

Journal Article Dis Colon Rectum · October 2000 Featured Publication After low colorectal or coloanal anastomosis, bowel dysfunction may exist. A colonic J-pouch has been proposed to reduce bowel dysfunction. We present an alternative technique to augment the reservoir function of the neorectum and reduce bowel dysfunction. ... Full text Link to item Cite

Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum.

Journal Article Gastroenterology · November 1996 Featured Publication BACKGROUND & AIMS: Nerves have been suggested to mediate the effects of bacterial toxins in intestinal diseases. However, the mechanisms involved are unknown. This study examined endogenous substance P (SP) activation of the substance P receptor (SPR) on e ... Full text Link to item Cite

Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo.

Journal Article Brain Res · May 6, 1996 Featured Publication Recent pharmacological and biochemical studies have suggested that there may be more than one molecular form of the neurokinin-1 receptor (NK-1), a long and short isoform differing in the length of their cytoplasmic carboxyl-terminal tails, but no definiti ... Full text Link to item Cite

Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis.

Journal Article Dig Dis Sci · March 1996 Featured Publication Pseudomembranous colitis is most often caused by toxins secreted by Clostridium difficile following bowel flora overgrowth after antibiotic use. The secretory and inflammatory effects observed in C. difficile toxin A-induced enterocolitis in the rat ileum ... Full text Link to item Cite

Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis.

Journal Article Gastroenterology · September 1995 Featured Publication BACKGROUND & AIMS: Although clinical and pathological differences exist between Crohn's disease (CD) and ulcerative colitis (UC), distinguishing features are often absent, making diagnosis and treatment problematic. This study evaluated the differences in ... Full text Link to item Cite

Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation.

Journal Article Science · June 16, 1995 Featured Publication In vivo somatosensory stimuli evoked the release of substance P from primary afferent neurons that terminate in the spinal cord and stimulated endocytosis of substance P receptors in rat spinal cord neurons. The distal dendrites that showed substance P rec ... Full text Link to item Cite

Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo.

Journal Article Proc Natl Acad Sci U S A · March 28, 1995 Featured Publication Studies on cultured cells have shown that agonists induce several types of G protein-coupled receptors to undergo internalization. We have investigated this phenomenon in rat striatum, using substance P (SP)-induced internalization of the SP receptor (SPR) ... Full text Link to item Cite

Reply

Other Gastroenterology · 1995 Cite

Localization of cholecystokinin A and cholecystokinin B/gastrin receptors in the canine upper gastrointestinal tract.

Journal Article Gastroenterology · October 1994 Featured Publication BACKGROUND/AIMS: Cholecystokinin (CCK) is a neuropeptide that exerts numerous effects in the gut. To determine the sites of action of CCK, the distribution and properties of CCK receptor subtypes were studied. METHODS: CCK receptors were localized by autor ... Full text Link to item Cite

Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors.

Journal Article Neurosci Lett · September 12, 1994 Featured Publication Previous reports have described the ectopic expression of substance P binding sites on lymphoid aggregates and small blood vessels in inflammatory bowel disease. In this report, three non-peptide NK-1 receptor antagonists, CP-96,345, RP-67,580, and L-703,6 ... Full text Link to item Cite

Effect of CGRP antagonist, alpha-CGRP 8-37, on acid secretion in the dog.

Journal Article Dig Dis Sci · July 1994 Featured Publication The recently synthesized calcitonin gene-related peptide (CGRP) antagonist, human alpha-CGRP 8-37, was used to study its effects on gastric acid secretion. Four dogs with gastric fistula were used to measure the antagonist's physiologic effects in the stom ... Full text Link to item Cite

Glomerular atrial natriuretic factor receptors in primary glomerulopathies: studies on human renal biopsies.

Journal Article Am J Kidney Dis · November 1989 Featured Publication Human renal biopsies are currently used to provide information about morphologic changes, chronicity of disease, patterns of inflammation, and immunoglobulin deposition. This practice has provided only limited insight into functional aberrations and has fa ... Full text Link to item Cite

Substance P receptors on canine chief cells: localization, characterization, and function.

Journal Article J Neurosci · August 1989 Featured Publication Saturable binding sites for 125I-Bolton-Hunter substance P were observed in frozen sections of the oxyntic mucosa of the canine stomach using quantitative autoradiography. The cell type possessing substance P binding sites in this region was identified as ... Full text Link to item Cite

Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues.

Journal Article J Neurosci · January 1989 Featured Publication Quantitative receptor autoradiography using several radiolabeled tachykinins was used to localize and characterize tachykinin peptide receptor binding sites in rat CNS and peripheral tissues. Autoradiographic localization and displacement experiments using ... Full text Link to item Cite

Calcitonin gene-related peptide-alpha receptor binding sites in the gastrointestinal tract.

Journal Article Neuroscience · 1989 Featured Publication Calcitonin gene-related peptide-alpha (CGRP alpha) is a putative neurotransmitter in the brain and in peripheral tissues. Quantitative receptor autoradiography was used to localize and quantify the distribution of specific binding sites for radiolabeled hu ... Full text Link to item Cite

Vasoactive intestinal polypeptide receptor binding sites in the human gastrointestinal tract: localization by autoradiography.

Journal Article Neuroscience · 1989 Featured Publication Vasoactive intestinal polypeptide (VIP) is a putative neurotransmitter in both the brain and peripheral tissues. To define possible target tissues of VIP we have used quantitative receptor autoradiography to localize and quantify the distribution of [125I] ... Full text Link to item Cite

Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons.

Journal Article Peptides · 1989 Glutamate and several neuropeptides are synthesized and released by subpopulations of primary afferent neurons. These sensory neurons play a role in regulating the inflammatory and immune responses in peripheral tissues. Using quantitative receptor autorad ... Full text Link to item Cite

Calcitonin gene-related peptide (CGRP) in the rat central nervous system: patterns of immunoreactivity and receptor binding sites.

Journal Article Brain Res · November 1, 1988 Featured Publication The distribution of immunoreactive (IR) axons and neurons in the rat central nervous system (CNS) has been studied with an antiserum directed against the C-terminal sequence of rat a-calcitonin gene-related peptide (CGRP) and a durable peroxidase reaction ... Full text Link to item Cite

Receptor binding sites for substance P and substance K in the canine gastrointestinal tract and their possible role in inflammatory bowel disease.

Journal Article Neuroscience · June 1988 Featured Publication The mammalian tachykinins, substance P, substance K (neurokinin A) and neuromedin K (neurokinin B), are putative peptide neurotransmitters in both the brain and peripheral tissues. We used quantitative receptor autoradiography to localize and quantify the ... Full text Link to item Cite

Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease.

Journal Article Proc Natl Acad Sci U S A · May 1988 Featured Publication Several lines of evidence indicate that tachykinin neuropeptides [substance P (SP), substance K (SK), and neuromedin K (NK)] play a role in regulating the inflammatory and immune responses. To test this hypothesis in a human inflammatory disease, quantitat ... Full text Link to item Cite

SUBSTANCE-P RECEPTORS ON CANINE CHIEF CELLS

Conference GASTROENTEROLOGY · May 1, 1988 Link to item Cite

The localization of sensory nerve fibers and receptor binding sites for sensory neuropeptides in canine mesenteric lymph nodes.

Journal Article Peptides · 1988 Featured Publication Previous work has established that the central nervous system can modulate the immune response. Direct routes through which this regulation may occur are the sympathetic and sensory innervation of lymphoid organs. We investigated the innervation of canine ... Full text Link to item Cite

Substance P and substance K receptor binding sites in the human gastrointestinal tract: localization by autoradiography.

Journal Article Peptides · 1988 Featured Publication Quantitative receptor autoradiography was used to localize and quantify the distribution of binding sites for 125I-radiolabeled substance P (SP), substance K (SK) and neuromedin K (NK) in the human GI tract using histologically normal tissue obtained from ... Full text Link to item Cite

Vasoactive intestinal peptide (VIP) receptors in the canine gastrointestinal tract.

Journal Article Peptides · 1988 Featured Publication Vasoactive intestinal peptide (VIP) is a putative neurotransmitter in both the brain and peripheral tissues. To define possible target tissues of VIP we have used quantitative receptor autoradiography to localize and quantify the distribution of 125I-VIP r ... Full text Link to item Cite

Receptor binding sites for atrial natriuretic factor are expressed by brown adipose tissue.

Journal Article Peptides · 1988 Featured Publication To explore the possibility that atrial natriuretic factor (ANF) is involved in thermoregulation we used quantitative receptor autoradiography and homogenate receptor binding assays to identify ANF bindings sites in neonatal rat and sheep brown adipose tiss ... Full text Link to item Cite

Localization of specific binding sites for bombesin in the canine gastrointestinal tract.

Journal Article Gastroenterology · December 1987 Featured Publication The goal of these studies was to determine the tissue and cell types possessing specific binding sites for bombesin/gastrin-releasing peptide in the canine gastrointestinal tract. Monoiodinated, biologically active (Tyr-4)-bombesin 14 (100 pM) was applied ... Full text Link to item Cite

Localization of specific binding sites for atrial natriuretic factor in the central nervous system of rat, guinea pig, cat and human.

Journal Article Brain Res · June 2, 1987 Featured Publication Specific, high-affinity binding sites for atrial natriuretic factor (ANF) were identified and localized in the rat and guinea pig central nervous system (CNS), the cat brainstem, and the rat, guinea pig, cat and human spinal cord using quantitative autorad ... Full text Link to item Cite

Estrous cyclicity of 125I-cholecystokinin octapeptide binding in the ventromedial hypothalamic nucleus. Evidence for downmodulation by estrogen.

Journal Article Neuroendocrinology · April 1987 Featured Publication Although there is a good correlation between the levels of gonadal steroids and sex differences in reproductive behavior and food intake, the neurochemical mechanisms by which a gonadal steroid may regulate these behaviors remain unknown. An important cent ... Full text Link to item Cite

Localization of specific binding sites for atrial natriuretic factor in peripheral tissues of the guinea pig, rat, and human.

Journal Article Hypertension · August 1986 Featured Publication Specific, high affinity atrial natriuretic factor (ANF) binding sites were identified and localized by autoradiographic techniques in peripheral tissues of the guinea pig, rat, and human. In the guinea pig kidney, high concentrations of ANF binding sites w ... Full text Link to item Cite