Scholars@Duke
Meira Epplein

Meira Epplein

Professor in Population Health Sciences
Population Health Sciences
meira.epplein@duke.edu
DUMC 2715, Durham, NC 27710
2424 Erwin Road, Suite 602, Durham, NC 27705

Selected Publications

Reply to S. Sorscher.

Journal Article J Clin Oncol · September 10, 2024 Full text Link to item Cite

Prevalence of the cagA Virulence Factor Varies by Race Among Helicobacter pylori -Infected Patients Undergoing Upper Endoscopy.

Journal Article Clin Transl Gastroenterol · June 1, 2024 INTRODUCTION: We designed a race-conscious study to assess the presence of Helicobacter pylori v irulence factor cagA in a retrospective cohort of patients with active H. pylori infection. METHODS: We compared cagA status by race in gastric tissue samples ... Full text Link to item Cite

Type 2 Diabetes Mellitus and Helicobacter pylori Eradication in a Clinical Population.

Journal Article South Med J · April 2024 OBJECTIVES: Eradication of Helicobacter pylori reduces the risk of gastric cancer (GC). Individuals with type 2 diabetes mellitus (T2DM) are known to be at increased risk for GC. In a cohort of H. pylori-positive individuals, we assessed whether those with ... Full text Link to item Cite

Helicobacter pylori testing prior to or at gastric cancer diagnosis and survival in a diverse US patient population.

Journal Article Gastric Cancer · January 2024 BACKGROUND: Gastric cancer (GC) accounts for the greatest disparity in cancer mortality between Black and White Americans. Although clinical trials have shown that Helicobacter pylori (Hp) treatment reduces risk of GC, Hp testing and treatment is not consi ... Full text Link to item Cite

Supplement use and gastric cancer risk in the Southern Community Cohort Study.

Journal Article Cancer Causes Control · October 2023 PURPOSE: Gastric cancer remains a racial health disparity in the US, but few studies have examined supplements as a potential protective factor. We examined associations between regular supplement use and gastric cancer risk among the predominantly Black p ... Full text Link to item Cite

Cancer Progress and Priorities: Gastric Cancer-Reply.

Journal Article Cancer Epidemiol Biomarkers Prev · September 1, 2023 Full text Link to item Cite

Abstract 5519: Biobanking of gastric organoid models from a racially diverse cohort for gastric cancer interception

Conference Cancer Research · April 4, 2023 AbstractPurpose: In the United States, significant disparities exist in gastric cancer incidence and mortality between Black Americans and non-Hispanic White Americans. Helicobacter pylori (HP) infection is ... Full text Cite

Cancer Progress and Priorities: Gastric Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · April 3, 2023 Gastric cancer, the fifth leading cause of cancer worldwide, is estimated to be responsible for approximately 1.4% of all new cancers and 1.8% of all cancer-related deaths in the United States. Despite declining incidence rates and improved survival rates, ... Full text Link to item Cite

Controlling Gastric Cancer in a World of Heterogeneous Risk.

Journal Article Gastroenterology · April 2023 Gastric cancer (GC) is a leading cause of global mortality but also a cancer whose footprint is highly unequal. This review aims to define global disease epidemiology, critically appraise strategies of prevention and disease attenuation, and assess how the ... Full text Link to item Cite

Discrimination between Precancerous Gastric Lesions and Gastritis Using a Gastric Cancer Risk Stratification Model.

Journal Article Asian Pac J Cancer Prev · March 1, 2023 BACKGROUND: Seropositivity to certain Helicobacter pylori proteins may affect development of gastric lesions that could become cancerous. Previously, we developed a model of gastric cancer risk including gender, age, HP0305 sero-positivity, HP1564 sero-pos ... Full text Link to item Cite

An Approach to the Primary and Secondary Prevention of Gastric Cancer in the United States.

Journal Article Clin Gastroenterol Hepatol · October 2022 BACKGROUND & AIMS: Gastric cancer (GC) remains a leading cause of mortality among certain racial, ethnic, and immigrant groups in the United States (US). The majority of GCs are diagnosed at advanced stages, and overall survival remains poor. There exist n ... Full text Link to item Cite

Serum Pepsinogen as a Biomarker for Gastric Cancer in the United States: A Nested Case-Control Study Using the PLCO Cancer Screening Trial Data.

Journal Article Cancer Epidemiol Biomarkers Prev · July 1, 2022 BACKGROUND: Gastric cancer lacks specific symptoms, resulting in diagnosis at later stages and high mortality. Serum pepsinogen is a biomarker for atrophic gastritis, a gastric cancer precursor, and may be useful to detect persons at increased risk of gast ... Full text Link to item Cite

A Predictive Model of Noncardia Gastric Adenocarcinoma Risk Using Antibody Response to Helicobacter pylori Proteins and Pepsinogen.

Journal Article Cancer Epidemiol Biomarkers Prev · April 1, 2022 BACKGROUND: Blood-based biomarkers for gastric cancer risk stratification could facilitate targeting screening to people who will benefit from it most. The ABC Method, which stratifies individuals by their Helicobacter pylori infection and serum-diagnosed ... Full text Link to item Cite

Serum antibodies to selected Helicobacter pylori antigens are associated with active gastritis in patients seen at the University Teaching Hospital in Lusaka, Zambia.

Journal Article Malawi Med J · March 2022 INTRODUCTION: Little is known about specific bacterial characteristics of Helicobacter pylori (H. pylori) infection influencing gastric carcinogenesis in Zambia. The aim of this study was to evaluate the associations between pre-selected H. pylori antibodi ... Full text Link to item Cite

Abstract PO-183: Racial disparities in Helicobacter pylori infection: A systematic review and retrospective study

Conference Cancer Epidemiology, Biomarkers & Prevention · January 1, 2022 AbstractBackground/Aims: Racial disparities exist across the spectrum of non-cardia gastric carcinogenesis, from H. pylori infection through gastric intestinal metaplasia and gastric cancer. Currently, there ... Full text Cite

Racial Differences in Helicobacter pylori Prevalence in the US: A Systematic Review.

Journal Article Gastro Hep Adv · 2022 BACKGROUND AND AIMS: Helicobacter pylori remains an important risk factor for noncardia gastric cancer and a spectrum of disease from H. pylori infection to gastric cancer. As a step toward improved clinical strategies for gastric cancer prevention, we ass ... Full text Link to item Cite

Prediagnostic Antibody Responses to Fusobacterium nucleatum Proteins Are Not Associated with Risk of Colorectal Cancer in a Large U.S. Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · June 2021 BACKGROUND: The association between prediagnostic antibody responses to Fusobacterium nucleatum (F. nucleatum) and subsequent risk of colorectal cancer is not established. METHODS: We conducted a nested case-control study of 8,126 participants in a consort ... Full text Link to item Cite

Risk factors for gastric cancers in the United States: Variation by anatomic site and race/ethnicity.

Conference Journal of Clinical Oncology · January 20, 2021 189 Background: Gastric cancer (GC) is a high mortality cancer in the US. Differences in risk factors by anatomic location and race/ethnicity have been suggested but remain understudied in the US population. Methods: The Multieth ... Full text Cite

Immunostimulatory membrane proteins potentiate H. pylori-induced carcinogenesis by enabling CagA translocation.

Journal Article Gut Microbes · 2021 Infection with Helicobacter pylori is the single greatest risk factor for developing gastric adenocarcinoma. In prospective, population-based studies, seropositivity to the uncharacterized H. pylori proteins Hp0305 and Hp1564 was significantly associated w ... Full text Link to item Cite

Adverse childhood experiences and adult diet quality.

Journal Article J Nutr Sci · 2021 Childhood trauma is strongly associated with poor health outcomes. Although many studies have found associations between adverse childhood experiences (ACEs), a well-established indicator of childhood trauma and diet-related health outcomes, few have explo ... Full text Link to item Cite

Auto-antibodies to p53 and the Subsequent Development of Colorectal Cancer in a U.S. Prospective Cohort Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2020 BACKGROUND: Auto-antibodies to tumor suppressor p53 are found in a subset of patients with colorectal cancer. A recent prospective study in the United States has reported a significant 1.8-fold increased odds for colorectal cancer development with prediagn ... Full text Link to item Cite

Association of Combined Sero-Positivity to Helicobacter pylori and Streptococcus gallolyticus with Risk of Colorectal Cancer.

Journal Article Microorganisms · October 30, 2020 Previously, we found that risk of colorectal cancer (CRC) is increased in individuals with serum antibody response to both Helicobacter pylori (HP) Vacuolating Cytotoxin (VacA) toxin or Streptococcus gallolyticus (SGG) pilus protein Gallo2178. In the prese ... Full text Link to item Cite

Racial Differences in Helicobacter pylori CagA Sero-prevalence in a Consortium of Adult Cohorts in the United States.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2020 BACKGROUND: Prevalence of Helicobacter pylori (H. pylori) infection, the main risk factor for gastric cancer, has been decreasing in the United States; however, there remains a substantial racial disparity. Moreover, the time-trends for prevalence of CagA- ... Full text Link to item Cite

A Summary of the 2020 Gastric Cancer Summit at Stanford University.

Journal Article Gastroenterology · October 2020 There exists no coherent national strategy for the early detection or prevention of gastric cancer in the United States (US), even among identified high-risk groups such as Asian Americans, African Americans, Hispanic Americans, and Alaska Native/American ... Full text Link to item Cite

The Durham Initiative for Stomach Health (DISH): a pilot community-based Helicobacter pylori education and screening study.

Journal Article BMC Gastroenterol · August 6, 2020 BACKGROUND: Approximately 15% of all cancers are due to infection. The bacteria Helicobacter pylori is the single leading carcinogenic infectious agent and the main cause of stomach cancer. Prevalence of H. pylori, and, correspondingly, stomach cancer inci ... Full text Link to item Cite

The U-shaped association between body mass index and gastric cancer risk in the Helicobacter pylori Biomarker Cohort Consortium: A nested case-control study from eight East Asian cohort studies.

Journal Article Int J Cancer · August 1, 2020 The association between body mass index (BMI) and noncardia gastric cancer (NCGC) risk remains controversial. The purpose of our study was to examine the association of BMI with NCGC risk with consideration of Helicobacter pylori (HP) biomarkers. This inte ... Full text Link to item Cite

Differences in antibody levels to H. pylori virulence factors VacA and CagA among African Americans and whites in the Southeast USA.

Journal Article Cancer Causes Control · June 2020 PURPOSE: Helicobacter pylori (H. pylori) is the leading cause of gastric cancer. High antibody levels to H. pylori virulence factors Vacuolating cytotoxin A (VacA) and Cytotoxin-associated gene A (CagA) have been suggested as gastric cancer risk markers. I ... Full text Link to item Cite

Auto-antibodies to p53 and the Subsequent Development of Colorectal Cancer in a United States Prospective Cohort Consortium

Conference Cancer Epidemiology, Biomarkers & Prevention · March 1, 2020 AbstractAuto-antibodies to tumor suppressor p53 are found in a subset of colorectal cancer (CRC) patients. A prospective cohort study in the US (Cancer Prevention Study II) has recently reported a statistica ... Full text Cite

Performance of multiplex serology in discriminating active vs past Helicobacter pylori infection in a primarily African American population in the southeastern United States.

Journal Article Helicobacter · February 2020 PURPOSE: To feasibly analyze associations of Helicobacter pylori (H. pylori) with disease in large cohort studies, assays are needed to assess H. pylori prevalence in existing biospecimens. However, serology has traditionally been unable to distinguish act ... Full text Link to item Cite

Smoking, Helicobacter Pylori Serology, and Gastric Cancer Risk in Prospective Studies from China, Japan, and Korea.

Conference Cancer Prev Res (Phila) · October 2019 Smoking is an established risk factor for gastric cancer development. In this study, we aimed to assess prospectively the association of smoking with gastric cancer risk in 1,446 non-cardia gastric cancer cases and 1,796 controls from China, Japan, and Kor ... Full text Link to item Cite

Reply.

Journal Article Gastroenterology · June 2019 Full text Link to item Cite

Serologic Response to Helicobacter pylori Proteins Associated With Risk of Colorectal Cancer Among Diverse Populations in the United States.

Conference Gastroenterology · January 2019 BACKGROUND & AIMS: Previous studies reported an association of the bacteria Helicobacter pylori, the primary cause of gastric cancer, and risk of colorectal cancer (CRC). However, these findings have been inconsistent, appear to vary with population charac ... Full text Link to item Cite

Validation of a Blood Biomarker for Identification of Individuals at High Risk for Gastric Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2018 BACKGROUND: Helicobacter pylori is the leading cause of gastric cancer, yet the majority of infected individuals will not develop neoplasia. Previously, we developed and replicated serologic H. pylori biomarkers for gastric cancer risk among prospective co ... Full text Link to item Cite

Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia.

Journal Article Dig Dis Sci · October 2018 BACKGROUND: Epstein-Barr virus (EBV)-positive gastric cancers represent a distinct subtype of gastric cancers and account for nearly 10% of the gastric cancer burden, yet risk detection strategies for this cancer subtype are lacking. METHODS: We conducted ... Full text Link to item Cite

Antibody Responses to Streptococcus Gallolyticus Subspecies Gallolyticus Proteins in a Large Prospective Colorectal Cancer Cohort Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2018 Background: Antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG) proteins, especially pilus protein Gallo2178, have been consistently associated with colorectal cancer risk. Previous case-control studies and prospective studies wi ... Full text Link to item Cite

Helicobacter pylori Blood Biomarkers and Gastric Cancer Survival in China.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2018 Background: Infection with Helicobacter pylori is the leading risk factor for noncardia gastric cancer, yet its influence on prognosis of gastric cancer is largely unknown. Thus, exploring the role of Helicobacter pylori (H. pylori) in survival could lead ... Full text Link to item Cite

Helicobacter Pylori-mediated carcinogenesis

Chapter · January 1, 2018 Helicobacter pylori is the most successful bacterial pathogen worldwide, coevolving with humans for millennia and currently infecting over 50% of the global populous. It is a Gram-negative, spiral-shaped organism that can evade the immune response for the ... Full text Cite

Abstract 2272: A prospective study of urinary prostaglandin E2 metabolite, Helicobacter pylori antibodies, and gastric cancer risk

Conference Cancer Research · July 1, 2017 AbstractBackground. Previous studies suggest that a stable end-product of prostaglandin E2, the urinary metabolite PGE-M, is excreted in the urine and can be used as an index of systemic prostaglandin E2 (PG ... Full text Cite

A Prospective Study of Urinary Prostaglandin E2 Metabolite, Helicobacter pylori Antibodies, and Gastric Cancer Risk.

Journal Article Clin Infect Dis · May 15, 2017 BACKGROUND: Previous studies suggest that a stable end-product of prostaglandin E2, the urinary metabolite PGE-M, is associated with colorectal cancer, and 1 study of relatively small sample size found an association with gastric cancer among women. In the ... Full text Link to item Cite

Fruit and vegetable consumption, Helicobacter pylori antibodies, and gastric cancer risk: A pooled analysis of prospective studies in China, Japan, and Korea.

Journal Article Int J Cancer · February 1, 2017 Epidemiological findings on the association between fruit and vegetable consumption and gastric cancer risk remain inconsistent. The present analysis included 810 prospectively ascertained non-cardia gastric cancer cases and 1,160 matched controls from the ... Full text Link to item Cite

Abstract LB-361: Serology of Streptococcus gallolyticus subsp. gallolyticus and risk of colorectal cancer

Conference Cancer Research · July 15, 2016 AbstractBackground: The colonic opportunist Streptococcus gallolyticus subsp. gallolyticus (S. gallolyticus) has been hypothesized to be associated with colorectal cancer (CRC). A recent case-control study ( ... Full text Cite

Abstract 1735: Fruit and vegetable consumption and risk of gastric cancer: a prospective nested case-control study in China, Japan and Korea

Conference Cancer Research · July 15, 2016 AbstractIntroduction: Epidemiological findings on the association between fruit and vegetable consumption and gastric cancer risk remain inconsistent, resulting in the designation of fruits and vegetables as ... Full text Cite

Helicobacter pylori blood biomarker for gastric cancer risk in East Asia.

Journal Article Int J Epidemiol · June 2016 BACKGROUND: Incidence and mortality rates for gastric cancer, the fifth most commonly diagnosed and third most deadly cancer worldwide, are highest in East Asia. We sought to identify gastric cancer risk biomarkers among eight prospective studies from Chin ... Full text Link to item Cite

Population-based cohort studies of type 2 diabetes and stomach cancer risk in Chinese men and women.

Journal Article Cancer Sci · March 2015 Although positive associations have been found for diabetes and a number of cancer sites, investigations of stomach cancer are limited and the results lack consistency. In this prospective study we investigated the relationship between type 2 diabetes mell ... Full text Link to item Cite

Challenges and opportunities in international molecular cancer prevention research: An ASPO Molecular Epidemiology and the Environment and International Cancer Prevention Interest Groups Report.

Journal Article Cancer Epidemiol Biomarkers Prev · November 2014 The International Agency for Research on Cancer estimates that over half of the new cancer cases and almost two-thirds of the cancer deaths in 2012 occurred in low and middle income countries. To discuss the challenges and opportunities to reducing the bur ... Full text Link to item Cite

A prospective study of plasma Selenoprotein P and lung cancer risk among low-income adults.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2014 BACKGROUND: Epidemiologic studies have shown increased risks of lung cancer among adults with low blood levels of selenium, although evidence is inconsistent. In the United States, the incidence of lung cancer is higher and mean serum selenium levels lower ... Full text Link to item Cite

Helicobacter pylori Biomarkers and Risk of Colorectal Oncogenesis--Response.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2014 Full text Link to item Cite

Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men.

Journal Article Nutr Cancer · 2014 Evidence for the association of diet and gastric cancer is equivocal, and the majority of previous studies have not evaluated the interaction of diet and infection with Helicobacter pylori, the leading risk factor for gastric cancer. We examined these asso ... Full text Link to item Cite

Circulating cytokines and gastric cancer risk.

Journal Article Cancer Causes Control · December 2013 PURPOSE: Chronic inflammation has been hypothesized to play a significant role in the aetiology of cancer, including gastric cancer. In the present study, we sought to examine pre-diagnostic systemic cytokine levels in plasma, which can be seen as markers ... Full text Link to item Cite

Helicobacter pylori protein-specific antibodies and risk of colorectal cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · November 2013 BACKGROUND: There is biologic plausibility as to why infection with Helicobacter pylori, the leading cause of gastric cancer, may also increase the risk of colorectal cancer, but the epidemiologic findings have been inconsistent. We assessed the associatio ... Full text Link to item Cite

Intake of specific nonfermented soy foods may be inversely associated with risk of distal gastric cancer in a Chinese population.

Journal Article J Nutr · November 2013 Because the association between soy consumption and gastric cancer is inconsistent, we evaluated the putative preventive effect of soy food on gastric cancer risk in the Shanghai Women's and Men's Health Studies, comprising a total of 128,687 participants. ... Full text Link to item Cite

Prospective study of Helicobacter pylori biomarkers for gastric cancer risk among Chinese men.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2012 BACKGROUND: Helicobacter pylori is the leading risk factor for gastric cancer, yet only a fraction of infected individuals ever develop neoplasia. METHODS: To identify potential predictive biomarkers, we assessed the association of 15 antibodies to H. pylo ... Full text Link to item Cite

Neighborhood socio-economic characteristics, African ancestry, and Helicobacter pylori sero-prevalence.

Journal Article Cancer Causes Control · June 2012 PURPOSE: The authors recently reported high Helicobacter pylori sero-prevalence among African-Americans of high African ancestry. We sought to determine whether neighborhood-level socio-economic characteristics are associated with H. pylori prevalence and ... Full text Link to item Cite

Abstract 1027: Helicobacter pylori blood biomarkers for gastric cancer risk in the Shanghai Men's Health Study

Conference Cancer Research · April 15, 2012 AbstractBackground: Helicobacter pylori is the leading identified risk factor for distal gastric cancer, yet only a fraction of infected individuals ever develop neoplasia. To identify potential risk markers ... Full text Cite

The association of cigarette smoking with gastric cancer: the multiethnic cohort study.

Journal Article Cancer Causes Control · January 2012 PURPOSE: The purpose of this study is to investigate the association of cigarette smoking with gastric cancer. METHODS: Over 215,000 men and women, representing five ethnic groups (African Americans, Japanese Americans, Latino Americans, Native Hawaiians, ... Full text Link to item Cite

Helicobacter pylori prevalence and circulating micronutrient levels in a low-income United States population.

Journal Article Cancer Prev Res (Phila) · June 2011 High prevalence of Helicobacter pylori (H. pylori), the leading cause of gastric cancer, and low levels of micronutrients have been observed in many developing countries, and the question remains as to the whether an association between the 2 exists. The p ... Full text Link to item Cite

Race, African ancestry, and Helicobacter pylori infection in a low-income United States population.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2011 BACKGROUND: Gastric cancer incidence in African Americans is twice that of whites, and differing prevalence of Helicobacter pylori strain-specific isolates may help explain the disparity. METHODS: Serum levels of antibodies to each of 15 H. pylori proteins ... Full text Link to item Cite

Quality of life after breast cancer diagnosis and survival.

Journal Article J Clin Oncol · February 1, 2011 PURPOSE: To examine the association of quality of life (QOL) after diagnosis of breast cancer with mortality and recurrence. PATIENTS AND METHODS: From 2002 to 2004, a total of 2,230 breast cancer survivors completed the General Quality of Life Inventory-7 ... Full text Link to item Cite

Gastric cancer: an infectious disease.

Journal Article Infect Dis Clin North Am · December 2010 The role of infectious agents and chronic inflammation in carcinogenesis is being increasingly recognized. It has been estimated that about 18% of cancers are directly linked to infections, particularly gastric adenocarcinoma (Helicobacter pylori), cervica ... Full text Link to item Cite

Fruit and vegetable consumption and risk of distal gastric cancer in the Shanghai Women's and Men's Health studies.

Journal Article Am J Epidemiol · August 15, 2010 Results from case-control and cohort studies of the association between fruit and vegetable consumption and gastric cancer risk have been inconsistent. Cases for the current study consisted of incident distal gastric cancers identified between 1996 and 200 ... Full text Link to item Cite

Complex hyperplasia with and without atypia: clinical outcomes and implications of progestin therapy.

Journal Article Obstet Gynecol · August 2010 OBJECTIVE: Limited data exist to inform clinicians and patients as to the likelihood of long-term endometrial hyperplasia response to progestin therapy, especially for atypical hyperplasia. We evaluated women with complex and atypical endometrial hyperplas ... Full text Link to item Cite

Association of maternal and intrauterine characteristics with age at menarche in a multiethnic population in Hawaii.

Journal Article Cancer Causes Control · February 2010 This study seeks to further elucidate the mother-daughter hormonal relationship and its effects on daughter's breast cancer risk through the association with early age at menarche. Four hundred and thirty-eight healthy girls, age 9-18 and of White, Asian, ... Full text Link to item Cite

Nonsteroidal antiinflammatory drugs and risk of gastric adenocarcinoma: the multiethnic cohort study.

Journal Article Am J Epidemiol · August 15, 2009 In many epidemiologic studies, investigators have reported an inverse relation between nonsteroidal antiinflammatory drugs (NSAIDs) and colon cancer, but fewer researchers have examined the relation with gastric cancer. Cases for this study consisted of in ... Full text Link to item Cite

Association of plasma micronutrient levels and urinary isoprostane with risk of lung cancer: the multiethnic cohort study.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2009 Although smoking is the primary risk factor for lung cancer, there is evidence to suggest that fruit and vegetable intake are important cofactors. The present case-control study, nested within the Multiethnic Cohort Study, examined the associations of biom ... Full text Link to item Cite

Incidence of endometrial hyperplasia.

Journal Article Am J Obstet Gynecol · June 2009 OBJECTIVE: The objective of the study was to estimate the age-specific incidence of endometrial hyperplasia: simple, complex, and atypical, in order of increasing likelihood of progression to carcinoma. STUDY DESIGN: Women aged 18-90 years with endometrial ... Full text Link to item Cite

Progestin therapy of complex endometrial hyperplasia with and without atypia

Journal Article Obstetrical and Gynecological Survey · June 1, 2009 Full text Cite

Progestin therapy of complex endometrial hyperplasia with and without atypia.

Journal Article Obstet Gynecol · March 2009 OBJECTIVE: To assess the likelihood of histologic persistence/progression of complex hyperplasia and atypical hyperplasia among women treated with progestin compared with those not treated, with attention to type, dose, and duration. METHODS: This was a co ... Full text Link to item Cite

Plasma carotenoids, retinol, and tocopherols and postmenopausal breast cancer risk in the Multiethnic Cohort Study: a nested case-control study.

Journal Article Breast Cancer Res · 2009 INTRODUCTION: Assessments by the handful of prospective studies of the association of serum antioxidants and breast cancer risk have yielded inconsistent results. This multiethnic nested case-control study sought to examine the association of plasma carote ... Full text Link to item Cite

Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2009 Although an association between diet, especially cruciferous vegetables, and colorectal cancer has been hypothesized, recent studies have been inconsistent with their findings. One possibility for the discrepant results is that the interaction with related ... Full text Link to item Cite

Endometrial hyperplasia risk in relation to recent use of oral contraceptives and hormone therapy.

Journal Article Ann Epidemiol · January 2009 PURPOSE: We sought to examine the relationship between recent use of oral contraceptives and hormone therapy and endometrial hyperplasia (EH) risk. METHODS: Cases comprised women diagnosed with complex EH (n = 289) or atypical EH (n = 173) between 1985 and ... Full text Link to item Cite

Association of Helicobacter pylori infection and diet on the risk of gastric cancer: a case-control study in Hawaii.

Journal Article Cancer Causes Control · October 2008 OBJECTIVE: The risk factors most strongly associated with gastric cancer are the gastric bacteria Helicobacter pylori and diet. Utilizing data from a case-control study among residents in Hawaii, we examined the association of diet, presence of H. pylori, ... Full text Link to item Cite

Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history.

Journal Article Am J Epidemiol · September 15, 2008 The authors sought to test the hypothesis that characteristics and exposures which influence the balance of estrogen and progesterone bear on the incidence of endometrial hyperplasia (EH), a noninvasive proliferation of the lining of the uterus. Cases incl ... Full text Link to item Cite

Epplein et al. respond to "endometrial hyperplasia - Getting back to normal"

Journal Article American Journal of Epidemiology · September 1, 2008 Full text Cite

Trends in the incidence rates of nasopharyngeal carcinoma among Chinese Americans living in Los Angeles County and the San Francisco metropolitan area, 1992-2002.

Journal Article Am J Epidemiol · December 15, 2005 Nasopharyngeal carcinoma is much more common in Asian countries than in Western countries. However, since the 1980s, nasopharyngeal carcinoma incidence has fallen among both men and women in Hong Kong, and recently a similar trend has also been noted in Si ... Full text Link to item Cite

Smoking-adjusted lung cancer incidence among Asian-Americans (United States).

Journal Article Cancer Causes Control · November 2005 OBJECTIVE: Chinese women residing in Asia and Hawaii have low consumption of tobacco but a high incidence of lung cancer. To explore this question further, we conducted a study of lung cancer among Chinese women residing in mainland US. METHODS: Using data ... Full text Link to item Cite

A sister's risk: family history as a predictor of preeclampsia.

Journal Article Am J Obstet Gynecol · September 2005 OBJECTIVE: The purpose of this study was to determine if women with preeclampsia are more likely to have a sister who also had preeclampsia. STUDY DESIGN: This was a population-based case-control study using data from Washington (WA) state birth certificat ... Full text Link to item Cite

Genetic services for familial cancer patients: a follow-up survey of National Cancer Institute Cancer Centers.

Journal Article J Clin Oncol · July 20, 2005 PURPOSE: Anecdotal reports suggest that the volume of services offered to individuals concerned with hereditary cancer risk has increased substantially in recent years. As a follow-up to our 1993 survey, we sought to determine how the scope and volume of g ... Full text Link to item Cite

A sister's risk: Family history as a predictor of hypertensive disorders of pregnancy

Conference American Journal of Obstetrics and Gynecology · December 2004 Full text Cite