Scholars@Duke
W. Robert Lee

W. Robert Lee

Professor Emeritus of Radiation Oncology
Radiation Oncology
w.robert.lee@duke.edu
Box 3085 Med Ctr, Durham, NC 27710
201 Trent Drive, Box 3085, Durham, NC 27710

Selected Publications

Updated 5-year results for short course abiraterone acetate and LHRH agonist for unfavorable intermediate and favorable high-risk prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · June 2025 Combined androgen deprivation therapy (ADT) and radiotherapy (RT) improves outcomes for intermediate and high-risk prostate cancer. Treatment intensification with abiraterone acetate/prednisone (AAP) provides additional benefit for high-risk disease. We pr ... Full text Link to item Cite

Hypofractionated radiotherapy for prostate cancer (HYDRA): an individual patient data meta-analysis of randomised trials in the MARCAP consortium.

Journal Article Lancet Oncol · April 2025 BACKGROUND: Trials comparing moderately hypofractionated radiotherapy (MHFRT) to conventionally-fractionated radiotherapy (CFRT) for prostate cancer have varied considerably in intent (non-inferiority vs superiority) and MHFRT dose. We compare the efficacy ... Full text Link to item Cite

The interplay between acute and late toxicity among patients receiving prostate radiotherapy: an individual patient data meta-analysis of six randomised trials.

Journal Article Lancet Oncol · March 2025 BACKGROUND: The association between acute and late toxicity following prostate radiotherapy has not been well studied using data from multiple randomised clinical trials and fractionation schedules. We aimed to characterise the relationship between acute a ... Full text Link to item Cite

Long-Term Analysis of NRG Oncology RTOG 0415: A Randomized Phase III Noninferiority Study Comparing Two Fractionation Schedules in Patients With Low-Risk Prostate Cancer.

Journal Article J Clin Oncol · July 10, 2024 Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Up ... Full text Link to item Cite

Radiation technique and outcomes following moderately hypofractionated treatment of low risk prostate cancer: a secondary analysis of RTOG 0415.

Journal Article Prostate Cancer Prostatic Dis · March 2024 BACKGROUND: While moderately hypofractionated radiotherapy (MHRT) for prostate cancer (PC) is commonly delivered by intensity modulated radiation therapy, IMRT has not been prospectively compared to three-dimensional conformal radiotherapy (3D-CRT) in this ... Full text Link to item Cite

Neighborhood Deprivation and Rurality Associated With Patient-Reported Outcomes and Survival in Men With Prostate Cancer in NRG Oncology RTOG 0415.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2023 PURPOSE: Rurality and neighborhood deprivation can contribute to poor patient-reported outcomes, which have not been systematically evaluated in patients with specific cancers in national trials. Our objective was to examine the effect of rurality and neig ... Full text Link to item Cite

Second generation anti-androgens and androgen deprivation therapy with radiation therapy in the definitive management of high-risk prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · March 2023 BACKGROUND: Evolving data suggest that men with high-risk localized prostate cancer may benefit from more potent androgen receptor inhibition in the context of curative intent radiotherapy. Recently updated American Society for Clinical Oncology (ASCO) evi ... Full text Link to item Cite

Toxicity and Outcomes of Moderately Hypofractionated Radiation for Prostate Cancer With Seminal Vesicle Involvement.

Journal Article Adv Radiat Oncol · 2023 PURPOSE: The aim of this study was to assess the toxicity and outcomes following treatment of prostate cancer with seminal vesicle involvement (SVI) evident on magnetic resonance imaging or clinical examination with moderately hypofractionated radiation th ... Full text Link to item Cite

The Influence of the Pretreatment Immune State on Response to Radiation Therapy in High-Risk Prostate Cancer: A Validation Study From NRG/RTOG 0521.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2022 PURPOSE: The immunoinflammatory state has been shown to be associated with poor outcomes after radiation therapy (RT). We conducted an a priori designed validation study using serum specimens from Radiation Therapy Oncology Group (RTOG) 0521. It was hypoth ... Full text Link to item Cite

Impact of Race on Outcomes of High-Risk Patients With Prostate Cancer Treated With Moderately Hypofractionated Radiotherapy in an Equal Access Setting.

Journal Article Fed Pract · August 2022 BACKGROUND: Moderately hypofractionated radiotherapy (MHRT) is an accepted treatment for localized prostate cancer; however, limited MHRT data address high-risk prostate cancer (HRPC) and/or African American patients. We report clinical outcomes and toxici ... Full text Link to item Cite

Methodological Comparison of Mapping the Expanded Prostate Cancer Index Composite to EuroQoL-5D-3L Using Cross-Sectional and Longitudinal Data: Secondary Analysis of NRG/RTOG 0415.

Journal Article JCO Clin Cancer Inform · June 2022 PURPOSE: To compare the predictive ability of mapping algorithms derived using cross-sectional and longitudinal data. METHODS: This methodological assessment used data from a randomized controlled noninferiority trial of patients with low-risk prostate can ... Full text Link to item Cite

Radiation technique and outcomes following moderately hypofractionated treatment of low risk prostate cancer: A secondary analysis of the NRG oncology RTOG 0415 randomized clinical trial.

Conference Journal of Clinical Oncology · February 20, 2022 243 Background: While intensity-modulated radiotherapy (IMRT) is commonly used to deliver moderately hypofractionated radiotherapy (MHRT) for prostate cancer (PC), IMRT has not been prospectively compared to three-dimensional con ... Full text Cite

Effect of Large Prostate Volume on Efficacy and Toxicity of Moderately Hypofractionated Radiation Therapy in Patients With Prostate Cancer.

Journal Article Adv Radiat Oncol · 2022 PURPOSE: To evaluate the effect of prostate volume on outcomes after moderately hypofractionated radiation therapy (mHFRT) for prostate cancer. METHODS AND MATERIALS: Prostate cancer patients treated with mHFRT at a Veteran's Affairs Medical Center from Au ... Full text Link to item Cite

Phase II Trial of Enzalutamide and Androgen Deprivation Therapy with Salvage Radiation in Men with High-risk Prostate-specific Antigen Recurrent Prostate Cancer: The STREAM Trial.

Journal Article Eur Urol Oncol · December 2021 BACKGROUND: Salvage external beam radiotherapy (RT) with androgen deprivation therapy (ADT) improves survival over RT in men with prostate cancer (PC) and rising prostate-specific antigen (PSA) levels after radical prostatectomy (RP). OBJECTIVE: To investi ... Full text Link to item Cite

Comparison of Response to Definitive Radiotherapy for Localized Prostate Cancer in Black and White Men: A Meta-analysis.

Journal Article JAMA Netw Open · December 1, 2021 IMPORTANCE: Black men have a 2-fold increased risk of dying from prostate cancer compared with White men. However, race-specific differences in response to initial treatment remain unknown. OBJECTIVE: To compare overall and treatment-specific outcomes of B ... Full text Link to item Cite

Five Year Results of Short Course Complete Androgen Blockade With Abiraterone Acetate and LHRH Agonist for Unfavorable Intermediate and Favorable High Risk Prostate Cancer.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Androgen deprivation therapy (ADT) and radiotherapy (RT) are synergistic, and the combination results in improved survival outcomes for aggressive prostate cancers. However, long-term ADT carries substantial burden of toxicity ... Full text Cite

Mapping expanded prostate cancer index composite to EQ5D utilities to inform economic evaluations in prostate cancer: Secondary analysis of NRG/RTOG 0415

Conference Plos One · April 1, 2021 Purpose The Expanded Prostate Cancer Index Composite (EPIC) is the most commonly used patient reported outcome (PRO) tool in prostate cancer (PC) clinical trials, but health utilities associated with the different health states assessed with this tool are ... Full text Cite

Combination of Radiation Therapy and Short-Term Androgen Blockade With Abiraterone Acetate Plus Prednisone for Men With High- and Intermediate-Risk Localized Prostate Cancer.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2021 PURPOSE: Long-term androgen-deprivation therapy (ADT) is the standard of care in combination with radiation therapy (RT) in high-risk prostate cancer (PC), despite substantial toxicity from the resulting hypogonadism. We hypothesized that a combination of ... Full text Link to item Cite

Prostate Radiotherapy With Adjuvant Androgen Deprivation Therapy (ADT) Improves Metastasis-Free Survival Compared to Neoadjuvant ADT: An Individual Patient Meta-Analysis.

Journal Article J Clin Oncol · January 10, 2021 PURPOSE: There remains a lack of clarity regarding the influence of sequencing of androgen deprivation therapy (ADT) and radiotherapy (RT) on outcomes in prostate cancer (PCa). Herein, we evaluate the optimal sequencing of ADT with prostate-directed RT in ... Full text Link to item Cite

Implementation and Impact of a Risk-Stratified Prostate Cancer Screening Algorithm as a Clinical Decision Support Tool in a Primary Care Network.

Conference J Gen Intern Med · January 2021 BACKGROUND: Implementation methods of risk-stratified cancer screening guidance throughout a health care system remains understudied. OBJECTIVE: Conduct a preliminary analysis of the implementation of a risk-stratified prostate cancer screening algorithm i ... Full text Link to item Cite

Mapping expanded prostate cancer index composite to EQ5D utilities to inform economic evaluations in prostate cancer: Secondary analysis of NRG/RTOG 0415.

Journal Article PLoS One · 2021 PURPOSE: The Expanded Prostate Cancer Index Composite (EPIC) is the most commonly used patient reported outcome (PRO) tool in prostate cancer (PC) clinical trials, but health utilities associated with the different health states assessed with this tool are ... Full text Open Access Link to item Cite

Association of Presalvage Radiotherapy PSA Levels After Prostatectomy With Outcomes of Long-term Antiandrogen Therapy in Men With Prostate Cancer.

Journal Article JAMA Oncol · May 1, 2020 IMPORTANCE: In men with recurrent prostate cancer, addition of long-term antiandrogen therapy to salvage radiotherapy (SRT) was associated with overall survival (OS) in the NRG/RTOG 9601 study. However, hormone therapy has associated morbidity, and there a ... Full text Link to item Cite

Editor's Note.

Journal Article Pract Radiat Oncol · 2020 Full text Link to item Cite

Multi-Institutional Analysis of Synchronous Prostate and Rectosigmoid Cancers.

Journal Article Front Oncol · 2020 Purpose: To perform a multi-institutional analysis of patients with synchronous prostate and rectosigmoid cancers. Materials and Methods: A retrospective review of Duke University and Durham Veterans Affairs Medical Center records was performed for men wit ... Full text Link to item Cite

Tolerance doses for late adverse events after hypofractionated radiotherapy for prostate cancer on trial NRG Oncology/RTOG 0415.

Journal Article Radiother Oncol · June 2019 PURPOSE/OBJECTIVE: Hypofractionated radiotherapy (HRT) regimens for prostate cancer are emerging, but tolerance doses for late adverse events are scarce. The purpose of this study is to define dose-volume predictors for late gastrointestinal and genitourin ... Full text Link to item Cite

Quality of Life in Patients With Low-Risk Prostate Cancer Treated With Hypofractionated vs Conventional Radiotherapy: A Phase 3 Randomized Clinical Trial.

Journal Article JAMA Oncol · May 1, 2019 IMPORTANCE: Hypofractionated radiotherapy (HRT) would be more convenient for men with low-risk prostate cancer and cost less than conventional radiotherapy (CRT) as long as HRT is noninferior to CRT in terms of survival and quality of life (QOL) is not fou ... Full text Link to item Cite

A Nomogram for Testosterone Recovery After Combined Androgen Deprivation and Radiation Therapy for Prostate Cancer.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2019 PURPOSE: Testosterone recovery (TR) after androgen deprivation therapy (ADT) and radiation therapy (RT) is not well characterized. We studied TR in men who received RT and either short-term ADT (STADT) or long-term ADT (LTADT) and aimed to create a nomogra ... Full text Link to item Cite

Multi-institutional analysis of synchronous prostate and rectosigmoid cancers.

Conference Journal of Clinical Oncology · March 1, 2019 33 Background: Synchronous prostate cancer (PC) and rectosigmoid (RS) cancer (RSC) is a challenging clinical situation. Methods: A retrospective review of Duke University and Durham VA charts was performed for men with adenocarci ... Full text Cite

Phase II trial enzalutamide and androgen deprivation therapy (ADT) with salvage radiation in men with high-risk PSA recurrent prostate cancer (PC): The STREAM trial.

Conference Journal of Clinical Oncology · March 1, 2019 29 Background: Salvage external beam radiotherapy (RT) and hormonal therapy improves survival over RT alone in men with non-metastatic hormone naïve PC and PSA recurrence after radical prostatectomy (RP). We investigated the safe ... Full text Cite

Nonuniform Planning Target Volume Margins for Prostate Bed on the Basis of Surgical Clips on Daily Cone Beam Computed Tomography.

Journal Article Adv Radiat Oncol · 2019 PURPOSE: We hypothesized that the interfraction motions of the superior and inferior prostate beds differ and therefore require different margins. In this study, we used daily cone beam computed tomography (CBCT) to evaluate the motion of postprostatectomy ... Full text Open Access Link to item Cite

ASTRO Journals' Data Sharing Policy and Recommended Best Practices.

Journal Article Adv Radiat Oncol · 2019 Transparency, openness, and reproducibility are important characteristics in scientific publishing. Although many researchers embrace these characteristics, data sharing has yet to become common practice. Nevertheless, data sharing is becoming an increasin ... Full text Link to item Cite

Sequence of hormonal therapy and radiotherapy field size in unfavourable, localised prostate cancer (NRG/RTOG 9413): long-term results of a randomised, phase 3 trial.

Journal Article Lancet Oncol · November 2018 BACKGROUND: The NRG/RTOG 9413 study showed that whole pelvic radiotherapy (WPRT) plus neoadjuvant hormonal therapy (NHT) improved progression-free survival in patients with intermediate-risk or high-risk localised prostate cancer compared with prostate onl ... Full text Link to item Cite

In recognition of the 2017 PRO reviewer apprentices

Journal Article Practical Radiation Oncology · September 1, 2018 Full text Cite

Effect of the Adoption of a Comprehensive Electronic Health Record on Graduate Medical Education: Perceptions of Faculty and Trainees.

Journal Article South Med J · August 2018 OBJECTIVES: Health systems are adopting electronic health records (EHRs). There are few studies on the effects of EHR implementation on graduate medical education. The authors sought to longitudinally assess perceptions of the impact of EHRs on graduate me ... Full text Link to item Cite

Scholarly Publishing and the Metric System.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2018 Full text Link to item Cite

Multi-institutional Evaluation of Elective Nodal Irradiation and/or Androgen Deprivation Therapy with Postprostatectomy Salvage Radiotherapy for Prostate Cancer.

Journal Article Eur Urol · July 2018 BACKGROUND: Outcomes with postprostatectomy salvage radiation therapy (SRT) are not ideal. Little evidence exists regarding potential benefits of adding whole pelvic radiation therapy (WPRT) alone or in combination with androgen deprivation therapy (ADT). ... Full text Link to item Cite

Postoperative Radiation Therapy for Prostate Cancer: Comparison of Conventional Versus Hypofractionated Radiation Regimens.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2018 PURPOSE: To compare acute/late toxicity and biochemical control in contemporaneous prostate cancer patient cohorts treated with hypofractionated postprostatectomy radiation therapy (hypoPORT) or conventional PORT (coPORT). METHODS AND MATERIALS: Consecutiv ... Full text Link to item Cite

Moderate hypofractionation for prostate cancer.

Journal Article Transl Androl Urol · June 2018 The biologic effects of changing the daily radiation dose (fractionation) have been studied for more than a century. The fractionation question in the treatment of prostate cancer came into stark relief in 1999 with the publication of a provocative report ... Full text Link to item Cite

Comparison Between Adjuvant and Early-Salvage Postprostatectomy Radiotherapy for Prostate Cancer With Adverse Pathological Features.

Journal Article JAMA Oncol · May 10, 2018 IMPORTANCE: Prostate cancer with adverse pathological features (ie, pT3 and/or positive margins) after prostatectomy may be managed with adjuvant radiotherapy (ART) or surveillance followed by early-salvage radiotherapy (ESRT) for biochemical recurrence. T ... Full text Link to item Cite

Phase II trial of 6 months ADT/abiraterone acetate plus prednisone (AAP) and definitive radiotherapy (AbiRT) for men with intermediate to high risk localized prostate cancer.

Conference Journal of Clinical Oncology · February 20, 2018 11 Background: Combined external beam radiotherapy (RT) and androgen deprivation therapy (ADT) improves survival over RT alone for high risk prostate cancer (PC). Long-term ADT use, currently recommended for high risk PC, also in ... Full text Cite

Optimal timing of post-prostatectomy radiotherapy for prostate cancer with high-risk pathologic features: A multi-institutional analysis.

Conference Journal of Clinical Oncology · February 20, 2018 24 Background: The use of radical prostatectomy (RP) as initial treatment of high-risk/locally-advanced prostate cancer is increasing but patients (pts) with adverse pathologic features such as positive surgical margins or T3 dis ... Full text Cite

Cost-Effectiveness of Primary Radiation Therapy Versus Radical Prostatectomy for Intermediate- to High-Risk Prostate Cancer.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2018 PURPOSE: To compare, using a cost-effectiveness analysis, the quality-adjusted life expectancy (QALE) and cost between the 2 treatment options for intermediate- to high-risk prostate cancer: (1) radiation (RT) with androgen deprivation therapy (ADT) or (2) ... Full text Link to item Cite

Exploring the Margin Recipe for Online Adaptive Radiation Therapy for Intermediate-Risk Prostate Cancer: An Intrafractional Seminal Vesicles Motion Analysis.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2017 PURPOSE: To provide a benchmark for seminal vesicle (SV) margin selection to account for intrafractional motion and to investigate the effectiveness of 2 motion surrogates in predicting intrafractional SV coverage. METHODS AND MATERIALS: Fifteen prostate p ... Full text Link to item Cite

Why the Aversion?

Journal Article J Grad Med Educ · April 2017 Full text Link to item Cite

A nomogram for testosterone recovery following combined androgen deprivation therapy and radiation therapy for prostate cancer.

Conference Journal of Clinical Oncology · February 20, 2017 67 Background: Combined androgen deprivation therapy (ADT) and radiation therapy (RT) is a frequently used localized prostate cancer (PC) treatment. Testosterone recovery (TR) after combined ADT-RT is not well-characterized. We s ... Full text Cite

Toxicity and quality of life report of a phase II study of stereotactic body radiotherapy (SBRT) for low and intermediate risk prostate cancer.

Journal Article Radiat Oncol · January 13, 2017 BACKGROUND: Clinical data indicates that delivery of larger daily doses of radiation may improve the therapeutic ratio for prostate cancer compared to conventional fractionation. A phase II study of stereotactic body radiotherapy with real-time motion mana ... Full text Link to item Cite

Salvage Radiation Therapy Dose Response for Biochemical Failure of Prostate Cancer After Prostatectomy-A Multi-Institutional Observational Study.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2016 PURPOSE: To determine whether a dose-response relationship exists for salvage radiation therapy (RT) of biochemical failure after prostatectomy for prostate cancer. METHODS AND MATERIALS: Individual data from 1108 patients who underwent salvage RT at 10 ac ... Full text Link to item Cite

Invited commentary on GETUG-AFU 16.

Journal Article Transl Androl Urol · December 2016 Full text Link to item Cite

Contemporary Update of a Multi-Institutional Predictive Nomogram for Salvage Radiotherapy After Radical Prostatectomy.

Conference J Clin Oncol · October 20, 2016 PURPOSE: We aimed to update a previously published, multi-institutional nomogram of outcomes for salvage radiotherapy (SRT) following radical prostatectomy (RP) for prostate cancer, including patients treated in the contemporary era. METHODS: Individual da ... Full text Link to item Cite

Developing Teaching Strategies in the EHR Era: A Survey of GME Experts.

Journal Article J Grad Med Educ · October 2016 BACKGROUND: There is limited information on the impact of widespread adoption of the electronic health record (EHR) on graduate medical education (GME). OBJECTIVE: To identify areas of consensus by education experts, where the use of EHR impacts GME, with ... Full text Link to item Cite

Randomized Phase III Noninferiority Study Comparing Two Radiotherapy Fractionation Schedules in Patients With Low-Risk Prostate Cancer.

Journal Article J Clin Oncol · July 10, 2016 PURPOSE: Conventional radiotherapy (C-RT) treatment schedules for patients with prostate cancer typically require 40 to 45 treatments that take place from > 8 to 9 weeks. Preclinical and clinical research suggest that hypofractionation-fewer treatments but ... Full text Link to item Cite

In regard to Wu and Vapiwala et al.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2016 Full text Link to item Cite

A phase 2 multimodality trial of docetaxel/prednisone with sunitinib followed by salvage radiation therapy in men with PSA recurrent prostate cancer after radical prostatectomy.

Conference Prostate Cancer Prostatic Dis · March 2016 BACKGROUND: In men with high Gleason PC and rapid PSA progression after surgery, failure rates remain unacceptably high despite salvage radiation. We explored a novel multimodality approach of docetaxel with anti-angiogenic therapy before salvage radiother ... Full text Link to item Cite

NRG Oncology RTOG 0415: A randomized phase III non-inferiority study comparing two fractionation schedules in patients with low-risk prostate cancer.

Conference Journal of Clinical Oncology · January 10, 2016 1 Background: To determine whether the efficacy of a hypofractionated (H) schedule is no worse than a conventional (C) schedule in men with low-risk prostate cancer. Methods: From April 2006 to December 2009, one thousand one hun ... Full text Cite

Longitudinal Trends in Costs of Palliative Radiation for Metastatic Prostate Cancer.

Conference J Palliat Med · November 2015 BACKGROUND: In recent years, palliative treatment of prostate cancer metastases has been characterized by the use of more complex radiation treatment, despite a lack of evidence demonstrating a clinical benefit of these technologies in the palliative setti ... Full text Link to item Cite

Atlas-guided prostate intensity modulated radiation therapy (IMRT) planning.

Journal Article Phys Med Biol · September 21, 2015 An atlas-based IMRT planning technique for prostate cancer was developed and evaluated. A multi-dose atlas was built based on the anatomy patterns of the patients, more specifically, the percent distance to the prostate and the concaveness angle formed by ... Full text Link to item Cite

Seduced by technology?

Journal Article Cancer · July 15, 2015 Full text Link to item Cite

Is radical prostatectomy appropriate for very-high-risk prostate cancer patients? No

Journal Article Oncology United States · May 15, 2015 It is our opinion that surgery is inappropriate for very-high-risk prostate cancer and that a combination of EBRT and ADT should be the preferred treatment modality. ... Cite

Quantitative comparison of automatic and manual IMRT optimization for prostate cancer: the benefits of DVH prediction.

Journal Article J Appl Clin Med Phys · March 8, 2015 A recent publication indicated that the patient anatomical feature (PAF) model was capable of predicting optimal objectives based on past experience. In this study, the benefits of IMRT optimization using PAF-predicted objectives as guidance for prostate w ... Full text Open Access Link to item Cite

Practice patterns for peer review in radiation oncology.

Journal Article Pract Radiat Oncol · 2015 PURPOSE: Physician peer review seeks to improve the quality of care through the evaluation of physician performance, specifically medical decision making and technical expertise. To establish current peer review practice patterns, evaluate interest in reco ... Full text Link to item Cite

Quantitative comparison of automatic and manual IMRT optimization for prostate cancer: The benefits of DVH prediction

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2015 A recent publication indicated that the patient anatomical feature (PAF) model was capable of predicting optimal objectives based on past experience. In this study, the benefits of IMRT optimization using PAF-predicted objectives as guidance for prostate w ... Full text Cite

Editor's note: Say "Yes!" to NO.

Journal Article Pract Radiat Oncol · 2015 Full text Link to item Cite

External beam radiation therapy for clinically localized prostate cancer

Chapter · January 1, 2015 Radiation therapy is used in approximately one-third of patients newly diagnosed with prostate cancer. External beam radiotherapy alone to doses of 75.6 Gy or higher is appropriate for patients with low risk disease (T1, GS<7, PSA≤10 ng/ml). For intermedia ... Full text Cite

Does the multidisciplinary approach improve oncological outcomes in men undergoing surgical treatment for prostate cancer?

Journal Article Int J Urol · December 2014 OBJECTIVES: To determine whether oncological outcomes are improved in prostate cancer patients by using a multidisciplinary strategy as compared with a standard clinic paradigm, and whether time to treatment is delayed when using a multidisciplinary approa ... Full text Link to item Cite

Reporting of uncertainty at the 2013 annual meeting of the American Society for Radiation Oncology.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2014 PURPOSE: The annual meeting of the American Society for Radiation Oncology (ASTRO) is designed to disseminate new scientific findings and technical advances to professionals. Best practices of scientific dissemination require that some level of uncertainty ... Full text Link to item Cite

Palliative radiotherapy for prostate cancer.

Journal Article Oncology (Williston Park) · April 2014 Radiotherapy is an effective tool for the palliation of symptoms commonly caused by prostate cancer. The majority of painful bone metastases respond equally well to single or multiple fractions of external radiotherapy. Retreatment with a second course of ... Link to item Cite

We need better figures!

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2014 Full text Link to item Cite

Palliative radiotherapy for prostate cancer.

Journal Article Oncology (Williston Park, N.Y.) · January 1, 2014 Radiotherapy is an effective tool for the palliation of symptoms commonly caused by prostate cancer. The majority of painful bone metastases respond equally well to single or multiple fractions of external radiotherapy. Retreatment with a second course of ... Cite

Practical Radiation Oncology (PRO).

Journal Article Pract Radiat Oncol · 2014 Full text Link to item Cite

Can electronic web-based technology improve quality of life data collection? Analysis of Radiation Therapy Oncology Group 0828.

Journal Article Pract Radiat Oncol · 2014 PURPOSE: Missing data are a significant problem in clinical trials, particularly for quality of life (QOL), which cannot be obtained retrospectively. The purpose of this study was to evaluate the feasibility of an electronic web-based strategy for QOL data ... Full text Link to item Cite

Strategies for automatic online treatment plan reoptimization using clinical treatment planning system: a planning parameters study.

Journal Article Med Phys · November 2013 PURPOSE: Adaptive radiation therapy for prostate cancer using online reoptimization provides an improved control of interfractional anatomy variations. However, the clinical implementation of online reoptimization is currently limited by the low efficiency ... Full text Link to item Cite

Prostate cancer and the hypofractionation hypothesis.

Journal Article J Clin Oncol · November 1, 2013 Full text Link to item Cite

Image Guidance Affects Biochemical Outcome for Postprostatectomy Radiation Therapy

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Early Results From the ASTRO Practice Patterns in Peer Review Survey Project

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Longitudinal Trends in Costs for Palliative Radiation for Metastatic Prostate Cancer

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Single institution's dosimetry and IGRT analysis of prostate SBRT.

Journal Article Radiat Oncol · September 13, 2013 BACKGROUND AND PURPOSE: To report single institution's IGRT and dosimetry analysis on the 37 Gy/5 fraction prostate SBRT clinical trial. MATERIALS/METHODS: The IRB (Duke University Medical Center) approved clinical trial has treated 28 patients with stage ... Full text Link to item Cite

A knowledge-based approach to improving and homogenizing intensity modulated radiation therapy planning quality among treatment centers: an example application to prostate cancer planning.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2013 PURPOSE: Intensity modulated radiation therapy (IMRT) treatment planning can have wide variation among different treatment centers. We propose a system to leverage the IMRT planning experience of larger institutions to automatically create high-quality pla ... Full text Link to item Cite

Phase 1 trial of neoadjuvant radiation therapy before prostatectomy for high-risk prostate cancer.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2013 PURPOSE: To evaluate, in a phase 1 study, the safety of neoadjuvant whole-pelvis radiation therapy (RT) administered immediately before radical prostatectomy in men with high-risk prostate cancer. METHODS AND MATERIALS: Twelve men enrolled and completed a ... Full text Link to item Cite

In regard to Shah.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2013 Full text Link to item Cite

In regard to Shah.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2013 Full text Link to item Cite

Intensity-modulated radiotherapy

Chapter · July 1, 2013 Intensity-modulated radiotherapy (IMRT) is a radiation delivery technique that allows dose sculpting to improve target coverage while sparing normal tissues. In an IMRT plan, the number of photons delivered (or fluence) varies within a field. Such variabil ... Full text Cite

In regard to Pinn-Bingham et al.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2013 Full text Link to item Cite

Radiation therapy for prostate cancer.

Journal Article Surg Oncol Clin N Am · July 2013 Radiation therapy is an effective treatment for newly diagnosed prostate cancer, salvage treatment, or for palliation of advanced disease. Herein we briefly discuss the indications, results, and complications associated with brachytherapy and external beam ... Full text Link to item Cite

Hypofractionation for clinically localized prostate cancer.

Journal Article Semin Radiat Oncol · July 2013 This manuscript reviews the clinical evidence for hypofractionation in prostate cancer, focusing on data from prospective trials. For the purposes of this manuscript, we categorize hypofractionation as moderate (2.4-4 Gy per fraction) or extreme (6.5-10 Gy ... Full text Link to item Cite

Image guidance for post-prostatectomy radiotherapy: Are we missing the mark?

Journal Article J Clin Oncol · February 20, 2013 56 Background: Image-guided radiation therapy (IGRT) has been widely adopted for both definitive and post-operative prostate radiotherapy. In the postoperative setting, numerous studies of prostate bed motion have recommended tight planning margins (<10mm) ... Full text Link to item Cite

Results from the Quality Research in Radiation Oncology (QRRO) survey: Evaluation of dosimetric outcomes for low-dose-rate prostate brachytherapy.

Journal Article Brachytherapy · 2013 PURPOSE: We report on quality of dose delivery to target and normal tissues from low-dose-rate prostate brachytherapy using postimplantation dosimetric evaluations from a random sample of U.S. patients. METHODS AND MATERIALS: Nonmetastatic prostate cancer ... Full text Link to item Cite

Evaluation of Adherence to Quality Measures for Prostate Cancer Radiotherapy in the United States: Results from the Quality Research in Radiation Oncology (QRRO) Survey.

Journal Article Pract Radiat Oncol · January 2013 PURPOSE: To test the feasibility of using proposed quality indicators to assess radiotherapy quality in prostate cancer management based on a 2007 stratified random survey of treating academic and non-academic US institutions. METHODS AND MATERIALS: 414 pa ... Full text Link to item Cite

Editor's Note.

Journal Article Pract Radiat Oncol · 2013 Full text Link to item Cite

Resident-reported brachytherapy experience in ACGME-accredited radiation oncology training programs.

Journal Article Brachytherapy · 2013 PURPOSE: To describe resident-reported experience in brachytherapy in Accreditation Council of Graduate Medical Education-accredited radiation oncology training programs over the last 5 years. METHODS AND MATERIALS: Archived reports of Accreditation Counci ... Full text Link to item Cite

Quantitative analysis of the factors which affect the interpatient organ-at-risk dose sparing variation in IMRT plans.

Journal Article Med Phys · November 2012 PURPOSE: The authors present an evidence-based approach to quantify the effects of an array of patient anatomical features of the planning target volumes (PTVs) and organs-at-risk (OARs) and their spatial relationships on the interpatient OAR dose sparing ... Full text Link to item Cite

Pelvic normal tissue contouring guidelines for radiation therapy: a Radiation Therapy Oncology Group consensus panel atlas.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2012 PURPOSE: To define a male and female pelvic normal tissue contouring atlas for Radiation Therapy Oncology Group (RTOG) trials. METHODS AND MATERIALS: One male pelvis computed tomography (CT) data set and one female pelvis CT data set were shared via the Im ... Full text Link to item Cite

Radiotherapy following radical prostatectomy.

Journal Article Expert Rev Anticancer Ther · July 2012 Radiotherapy following radical prostatectomy has been controversial and no consensus has developed on the most appropriate use of radiotherapy after radical prostatectomy. In the last decade the results of three randomized controlled trials examining the e ... Full text Link to item Cite

SU-E-J-16: Prostate Bed Motion during Post-Prostatectomy Radiotherapy.

Journal Article Med Phys · June 2012 PURPOSE: To report the inter-fractional prostate bed motion (PBM) during post-prostatectomy radiotherapy using cone-beam CT (CBCT). The correlations between PBM, anterior rectal wall and posterior bladder wall shifts were also investigated. METHODS: Sevent ... Full text Link to item Cite

SU-E-T-406: Online Image-Guidance for Prostate SBRT: Dosimetric Benefits and Margin Analysis.

Conference Med Phys · June 2012 PURPOSE: To evaluate the dosimetric benefits of online image guidance during prostate stereotactic body radiotherapy (SBRT) and the potential on margin reduction. METHODS: 28 prostate SBRT patients were retrospectively studied, each treated with 37Gy in 5 ... Full text Link to item Cite

Long-term results of an RTOG Phase II trial (00-19) of external-beam radiation therapy combined with permanent source brachytherapy for intermediate-risk clinically localized adenocarcinoma of the prostate.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 PURPOSE: External-beam radiation therapy combined with low-doserate permanent brachytherapy are commonly used to treat men with localized prostate cancer. This Phase II trial was performed to document late gastrointestinal or genitourinary toxicity as well ... Full text Link to item Cite

Changes in initial treatment for prostate cancer among Medicare beneficiaries, 1999-2007.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 PURPOSE: In the absence of evidence from large clinical trials, optimal therapy for localized prostate cancer remains unclear; however, treatment patterns continue to change. We examined changes in the management of patients with prostate cancer in the Med ... Full text Link to item Cite

Development and clinical evaluation of a three-dimensional cone-beam computed tomography estimation method using a deformation field map.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 PURPOSE: To develop a three-dimensional (3D) cone-beam computed tomography (CBCT) estimation method using a deformation field map, and to evaluate and optimize the efficiency and accuracy of the method for use in the clinical setting. METHODS AND MATERIALS ... Full text Link to item Cite

Comparative analysis of prostate-specific antigen free survival outcomes for patients with low, intermediate and high risk prostate cancer treatment by radical therapy. Results from the Prostate Cancer Results Study Group.

Journal Article BJU Int · February 2012 What's known on the subject? and What does the study add? Very few comparative studies to date evaluate the results of treatment options for prostate cancer using the most sensitive measurement tools. PSA has been identified as the most sensitive tool for ... Full text Link to item Cite

Editor's Note.

Journal Article Pract Radiat Oncol · 2012 Full text Link to item Cite

Editor's Note.

Journal Article Pract Radiat Oncol · 2012 Full text Link to item Cite

Utilization trends at a multidisciplinary prostate cancer clinic: initial 5-year experience from the Duke Prostate Center.

Journal Article J Urol · January 2012 PURPOSE: The multidisciplinary approach is becoming increasingly encouraged but little is known about the multidisciplinary experience compared to routine care. For patients with prostate cancer the goal is to provide evaluations by urologists, medical and ... Full text Link to item Cite

Impact of primary Gleason grade on risk stratification for Gleason score 7 prostate cancers.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2012 PURPOSE: To evaluate the primary Gleason grade (GG) in Gleason score (GS) 7 prostate cancers for risk of non-organ-confined disease with the goal of optimizing radiotherapy treatment option counseling. METHODS: One thousand three hundred thirty-three patie ... Full text Link to item Cite

American Brachytherapy Society consensus guidelines for transrectal ultrasound-guided permanent prostate brachytherapy.

Journal Article Brachytherapy · 2012 PURPOSE: To provide updated American Brachytherapy Society (ABS) guidelines for transrectal ultrasound-guided transperineal interstitial permanent prostate brachytherapy (PPB). METHODS AND MATERIALS: The ABS formed a committee of brachytherapists and resea ... Full text Link to item Cite

Phase III trial of selenium to prevent prostate cancer in men with high-grade prostatic intraepithelial neoplasia: SWOG S9917.

Journal Article Cancer Prev Res (Phila) · November 2011 The threat of prostate cancer and the significant and often negative impact of its treatment underscore the importance of prevention. High-grade prostatic intraepithelial neoplasia (HGPIN) has been identified as a potential premalignant lesion marking an i ... Full text Link to item Cite

External beam radiation therapy for clinically localized prostate cancer: when and how we optimize with concurrent hormonal deprivation.

Journal Article Arch Esp Urol · October 2011 Androgen deprivation plays a major role in the treatment of prostate cancer.Preclinical studies have shown that androgen deprivation provides both an independent cytotoxic effect and radiosensitization on prostate tumors. For men with non-metastatic prosta ... Link to item Cite

3D Conformal and Intensity Modulated Radiotherapy to the Prostate Bed have Similar Biochemical Outcomes

Conference International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Neoadjuvant Radiotherapy plus Prostatectomy for High Risk Prostate Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Electronic Web-based Technology Significantly Improves Quality of Life (QOL) Data Collection: Analysis of RTOG 0828

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Salvage radiation in men after prostate-specific antigen failure and the risk of death.

Journal Article Cancer · September 1, 2011 BACKGROUND: A survival benefit has been observed with salvage radiation therapy (RT) for prostate-specific antigen (PSA) failure after radical prostatectomy (RP) in men with rapid rises in PSA doubling time (DT, < 6 months). Whether such a benefit exits in ... Full text Link to item Cite

Long-term results of a phase II trial of ultrasound-guided radioactive implantation of the prostate for definitive management of localized adenocarcinoma of the prostate (RTOG 98-05).

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2011 PURPOSE: To evaluate the long-term effectiveness of transrectal ultrasound-guided permanent radioactive I125 implantation of the prostate for organ confined adenocarcinoma of the prostate compared with historical data of prostatectomy and external beam rad ... Full text Link to item Cite

Does enrollment setting influence patient attributes and outcomes in RTOG prostate cancer trials?

Journal Article J Clin Oncol · May 20, 2011 4607 Background: The external validity of randomized trials (generalizability) has been called into question following the finding that patients treated on clinical trials vary substantially from patients treated in the usual care setting. The purpose of t ... Link to item Cite

Financial implications of changes in the initial treatment of prostate cancer among Medicare beneficiaries.

Journal Article J Clin Oncol · May 20, 2011 6115 Background: The traditional treament approaches for localized prostate cancer have included androgen suppression, watchful waiting, open radical prostatectomy, external beam radiation therapy and interstitial brachytherapy. In the last decade a number ... Link to item Cite

Knowledge-based IMRT treatment planning for prostate cancer.

Journal Article Med Phys · May 2011 PURPOSE: To demonstrate the feasibility of using a knowledge base of prior treatment plans to generate new prostate intensity modulated radiation therapy (IMRT) plans. Each new case would be matched against others in the knowledge base. Once the best match ... Full text Link to item Cite

Incorporating gross anatomy education into radiation oncology residency: a 2-year curriculum with evaluation of resident satisfaction.

Journal Article J Am Coll Radiol · May 2011 PURPOSE: Radiation oncologists require a thorough understanding of anatomy, but gross anatomy is not part of the standard residency curriculum. "Oncoanatomy" is an educational program for radiation oncology residents at Duke University that integrates cada ... Full text Link to item Cite

Editorial comment.

Journal Article Urology · April 2011 Full text Link to item Cite

Editorial comment.

Journal Article Urology · April 2011 Full text Link to item Cite

Adaptive prostate IGRT combining online re-optimization and re-positioning: a feasibility study.

Journal Article Phys Med Biol · March 7, 2011 In prostate radiation therapy, inter-fractional organ motion/deformation has posed significant challenges on reliable daily dose delivery. To correct for this issue, off-line re-optimization and online re-positioning have been used clinically. In this pape ... Full text Link to item Cite

Teaching the anatomy of oncology: evaluating the impact of a dedicated oncoanatomy course.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2011 PURPOSE: Anatomic considerations are often critical in multidisciplinary cancer care. We developed an anatomy-focused educational program for radiation oncology residents integrating cadaver dissection into the didactic review of diagnostic, surgical, radi ... Full text Link to item Cite

American Society for Radiation Oncology (ASTRO) and American College of Radiology (ACR) practice guideline for the transperineal permanent brachytherapy of prostate cancer.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2011 Transperineal permanent prostate brachytherapy is a safe and efficacious treatment option for patients with organ-confined prostate cancer. Careful adherence to established brachytherapy standards has been shown to improve the likelihood of procedural succ ... Full text Link to item Cite

[Not Available].

Journal Article Pract Radiat Oncol · 2011 Full text Link to item Cite

Editor's Note.

Journal Article Pract Radiat Oncol · 2011 Full text Link to item Cite

Editor's Note.

Journal Article Pract Radiat Oncol · 2011 Full text Link to item Cite

[Not Available].

Journal Article Pract Radiat Oncol · 2011 Full text Link to item Cite

The development of oncology treatment guidelines: an analysis of the National Guidelines Clearinghouse.

Journal Article Pract Radiat Oncol · 2011 PURPOSE: In the last 2 decades, guidelines have been developed to improve quality of patient care. A recent editorial of guideline development procedures suggested the process has significant limitations that affect their scientific validity.(1) This promp ... Full text Link to item Cite

Adjuvant versus salvage radiation therapy for prostate cancer and the risk of death.

Journal Article BJU Int · December 2010 OBJECTIVE: To investigate whether salvage radiation therapy (RT) for prostate-specific antigen (PSA) failure can provide the same result as adjuvant RT, which decreases the risk of all-cause mortality (ACM) for men with positive margins (R1), or extra-caps ... Full text Link to item Cite

Salvage Radiation in Men with PSA Failure following Radical Prostatectomy and the Risk of Death

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Incorporating Gross Anatomy Education into Radiation Oncology Residency

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

The beginning of a new journal.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2010 Full text Link to item Cite

Carcinoma of the urethra: radiation oncology.

Journal Article Urol Clin North Am · August 2010 Urethral cancer is a rare but aggressive neoplasm. Early-stage distal lesions can be successfully treated with a single modality. Results for definitive radiotherapy using either or both external beam radiation therapy and brachytherapy have shown excellen ... Full text Link to item Cite

Editorial comment.

Journal Article Urology · June 2010 Full text Link to item Cite

Seduced by dose?

Journal Article J Clin Oncol · March 1, 2010 Full text Link to item Cite

Radiotherapy treatment plans with RapidArc for prostate cancer involving seminal vesicles and lymph nodes.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2010 PURPOSE: Dosimetric results and treatment delivery efficiency of RapidArc plans to those of conventional intensity-modulated radiotherapy (IMRT) plans were compared using the Eclipse treatment planning system for high-risk prostate cancer. MATERIALS AND ME ... Full text Link to item Cite

Development of RTOG consensus guidelines for the definition of the clinical target volume for postoperative conformal radiation therapy for prostate cancer.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2010 PURPOSE: To define a prostate fossa clinical target volume (PF-CTV) for Radiation Therapy Oncology Group (RTOG) trials using postoperative radiotherapy for prostate cancer. METHODS AND MATERIALS: An RTOG-sponsored meeting was held to define an appropriate ... Full text Link to item Cite

The effects of iohexol administration on technetium thyroid scintigraphy in normal cats.

Journal Article Vet Radiol Ultrasound · 2010 Administration of iodinated contrast medium interferes with iodide uptake in the human thyroid gland and compromises diagnostic thyroid scintigraphy and radioiodine treatment for 4-6 weeks. However, the degree and duration of inhibition of thyroid uptake o ... Full text Link to item Cite

On-line adaptive radiation therapy: feasibility and clinical study.

Journal Article J Oncol · 2010 The purpose of this paper is to evaluate the feasibility and clinical dosimetric benefit of an on-line, that is, with the patient in the treatment position, Adaptive Radiation Therapy (ART) system for prostate cancer treatment based on daily cone-beam CT i ... Full text Open Access Link to item Cite

In Reply to Dr. Lawrence

Journal Article International Journal of Radiation Oncology Biology Physics · November 15, 2009 Full text Cite

Robot-assisted laparoscopic prostatectomy is not associated with early postoperative radiation therapy.

Journal Article BJU Int · November 2009 OBJECTIVE: To compare open radical prostatectomy (RP) and robot-assisted laparoscopic prostatectomy (RALP), and to determine whether RALP is associated with a higher risk of features that determine recommendations for postoperative radiation therapy (RT). ... Full text Link to item Cite

Hybrid IGRT Technique for Prostate Hypofractionation

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Performance Assessment for the Advancement of Radiation Oncology Treatment (PAAROT): Aggregate Data from the First Year

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Low-dose-rate Prostate Brachytherapy: Predictors of Freedom from Biochemical Recurrence

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Treatment Plan Comparison between IMRT and Volumetric IMAT using One- and Two-arc Beams for Prostate Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Variation in the definition of clinical target volumes for pelvic nodal conformal radiation therapy for prostate cancer.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2009 Featured Publication PURPOSE: We conducted a comparative study of clinical target volume (CTV) definition of pelvic lymph nodes by multiple genitourinary (GU) radiation oncologists looking at the levels of discrepancies amongst this group. METHODS AND MATERIALS: Pelvic compute ... Full text Link to item Cite

RTOG GU Radiation oncology specialists reach consensus on pelvic lymph node volumes for high-risk prostate cancer.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2009 Featured Publication PURPOSE: Radiation therapy to the pelvic lymph nodes in high-risk prostate cancer is required on several Radiation Therapy Oncology Group (RTOG) clinical trials. Based on a prior lymph node contouring project, we have shown significant disagreement in the ... Full text Link to item Cite

Comparison of online IGRT techniques for prostate IMRT treatment: adaptive vs repositioning correction.

Journal Article Med Phys · May 2009 This study compares three online image guidance techniques (IGRT) for prostate IMRT treatment: bony-anatomy matching, soft-tissue matching, and online replanning. Six prostate IMRT patients were studied. Five daily CBCT scans from the first week were acqui ... Full text Link to item Cite

Editorial Comment

Journal Article Journal of Urology · April 1, 2009 Full text Cite

The ethics of hypofractionation for prostate cancer.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2009 Featured Publication Full text Link to item Cite

SU‐FF‐J‐55: Acceptance Testing and Quality‐Assurance Protocols for the Calypso® 4D Localization System™ and Q‐Fix®/Calypso® Couchtop

Conference Medical Physics · January 1, 2009 Purpose: To develop quality‐assurance (QA) protocols for the Calypso® 4D Localization System including acceptance testing, commissioning, daily QA, monthly QA, and annual QA. Method and Materials: The following acceptance testing/commissioning/QA protocols ... Full text Cite

SU‐FF‐T‐574: Radiotherapy Treatment Plans with RapidArc for Prostate Cancer Involving Seminal Vesicles

Conference Medical Physics · January 1, 2009 Purpose: The purpose of this report is to compare RapidArc plans and conventional IMRT plans for prostate cancer involving seminal vesicles. Methods and Materials: This study included 10 patients. The planning‐target volume (PTV) contained the prostate and ... Full text Cite

Extreme hypofractionation for prostate cancer.

Journal Article Expert Rev Anticancer Ther · January 2009 Featured Publication In ideal circumstances the fractionation schedule of radiotherapy should match the fractionation sensitivity of the tumor relative to the nearby normal tissues. A number of recent publications have suggested that the alpha/beta ratio for prostate tumors is ... Full text Link to item Cite

Morbidity and prostate-specific antigen control of external beam radiation therapy plus low-dose-rate brachytherapy boost for low, intermediate, and high-risk prostate cancer.

Journal Article Brachytherapy · 2009 PURPOSE: Dose escalation has been shown beneficial in prostate cancer. Brachytherapy (BT) provides an opportunity for dose escalation beyond what can be safely delivered using only teletherapy methods. The purpose of this study was to determine cancer cont ... Full text Link to item Cite

Clinical evaluation of positioning verification using digital tomosynthesis and bony anatomy and soft tissues for prostate image-guided radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2009 PURPOSE: To evaluate on-board digital tomosynthesis (DTS) for patient positioning vs. two-dimensional (2D) radiography and three-dimensional cone beam (CBCT). METHODS AND MATERIALS: A total of 92 image sessions from 9 prostate cancer patients were analyzed ... Full text Link to item Cite

Radiation therapy for clinically localized prostate cancer

Journal Article · December 1, 2008 Radiation therapy (RT) is one of the two main local treatments for clinically localized prostate cancer; radical prostatectomy (RP) is the other. The treatment options that are available for a particular patient are extensive and can include expectant mana ... Full text Cite

What Factors Influence Referral for Postoperative Radiation Therapy for Prostate Cancer?

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

Dosimetrical Evaluation of an Online Adaptive IMRT Technique

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

Androgen suppression and radiotherapy? Yes, but...

Journal Article American Journal of Hematology Oncology · April 1, 2008 Cite

Technology assessment: vigilance required.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2008 Featured Publication Full text Link to item Cite

On-line re-optimization of prostate IMRT plans for adaptive radiation therapy.

Journal Article Phys Med Biol · February 7, 2008 Featured Publication For intermediate and high risk prostate cancer, both the prostate gland and seminal vesicles are included in the clinical target volume. Internal motion patterns of these two organs vary, presenting a challenge for adaptive treatment. Adaptive techniques s ... Full text Link to item Cite

SU‐GG‐J‐81: Efficacy of Patient Setup Correction Procedure in Prostate Radiotherapy

Conference Medical Physics · January 1, 2008 Purpose: Using an on‐board cone‐beam CT (CBCT) based statistical margin model to determine whether a prostate center‐of‐mass (COM) based translation correction procedure can significantly reduce the CTV‐to‐PTV margin required for prostate patients who were ... Full text Cite

SU‐GG‐T‐53: Integrating An Online Adaptive IMRT Process to the Prostate IGRT

Conference Medical Physics · January 1, 2008 Purpose: To investigate the feasibility of a novel online IMRT re‐optimization process. This online process can be an integral part to the current prostate IGRT paradigm to augment the existing patient alignment techniques for cases with complex daily orga ... Full text Cite

SU‐GG‐T‐13: Fast Seed Localization On MR Images For Post‐Prostate Implant Dosimetry

Conference Medical Physics · January 1, 2008 Purpose: Accurate and reliable post‐prostate implant dosimetric analysis requires optimal identification of the seeds on CT and optimal description of soft tissues on MRI. We present a fast seed localization technique for MRI that is also robust from motio ... Full text Cite

SU‐GG‐T‐54: On‐Line Adaptive IMRT for Prostate Cancer

Conference Medical Physics · January 1, 2008 Purpose: This study proposes a novel on‐line IGRT technique that can modify the original IMRT plan to match with the “anatomy‐of‐the‐day” within few minutes. The performance of this technique is compared with current on‐line IGRT strategies using bone/soft ... Full text Cite

Pretreatment prostate-specific antigen velocity is associated with freedom from biochemical recurrence of prostate cancer after low-dose-rate prostate brachytherapy alone.

Journal Article Brachytherapy · 2008 Featured Publication PURPOSE: This report examines the relationship between pretreatment prostate-specific antigen (PSA) velocity (PSAV) and freedom from biochemical recurrence (FFBR) in men with prostate cancer treated with low-dose-rate prostate brachytherapy (LDRPB). METHOD ... Full text Link to item Cite

Hypofractionation for prostate cancer: a critical review.

Journal Article Semin Radiat Oncol · January 2008 Featured Publication In ideal circumstances, the fractionation schedule of radiotherapy should match the fractionation sensitivity of the tumor relative to the nearby normal tissues. A number of recent publications have suggested that the alpha-beta ratio (alpha/beta) for pros ... Full text Link to item Cite

Reducing biochemical recurrence rates in EBRT-treated prostate cancer patients: the influence of dose and dose per fraction.

Journal Article Future Oncol · December 2007 Featured Publication In the last 15-20 years, technological improvements in radiation treatment planning and delivery have allowed radiation oncologists to increase the total dose to the prostate gland. The results of four randomized trials using conventional daily doses (1.8- ... Full text Link to item Cite

Follow-up after EBRT falls short of guideline: Commentary

Other Oncology Report · September 1, 2007 Cite

Adjuvant radiotherapy averts biochemical progression

Other Oncology Report · September 1, 2007 Cite

Male breast cancer during treatment with leuprolide for prostate cancer.

Journal Article Clin Adv Hematol Oncol · July 2007 Featured Publication Link to item Cite

Late toxicity and biochemical recurrence after external-beam radiotherapy combined with permanent-source prostate brachytherapy: analysis of Radiation Therapy Oncology Group study 0019.

Journal Article Cancer · April 15, 2007 Featured Publication BACKGROUND: The combination of external-beam radiotherapy and brachytherapy is used commonly to treat men with prostate cancer. In this analysis, the authors examined the rate of biochemical recurrence (BR) and late grade > or =3 genitourinary (GU) and gas ... Full text Link to item Cite

A simple model predicts freedom from biochemical recurrence after low-dose rate prostate brachytherapy alone.

Journal Article Am J Clin Oncol · April 2007 Featured Publication OBJECTIVE: The objective of this study was to describe a simple model that predicts freedom from biochemical recurrence (FFBR) in men with prostate cancer after treatment with low-dose rate prostate brachytherapy (LDRPB) alone. MATERIALS AND METHODS: One h ... Full text Link to item Cite

Does a delay in initiating definitive therapy affect biochemical recurrence rates in men with clinically localized prostate cancer?

Journal Article Urol Oncol · 2007 Featured Publication PURPOSE: To assess whether a delay in initiating definitive therapy for clinically localized prostate cancer affects outcome. METHODS: We retrospectively reviewed 393 men with localized prostate cancer treated with radiation therapy or surgery without syst ... Full text Link to item Cite

Prostate brachytherapy: a descriptive analysis from CaPSURE.

Journal Article Brachytherapy · 2007 Featured Publication PURPOSE: The purpose of this study was to describe demographic and clinical characteristics in a large disease registry of prostate cancer patients treated with prostate brachytherapy (PB) and to identify factors influencing the use of supplemental externa ... Full text Link to item Cite

Results of a phase II trial of transrectal ultrasound-guided permanent radioactive implantation of the prostate for definitive management of localized adenocarcinoma of the prostate (radiation therapy oncology group 98-05).

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2007 Featured Publication PURPOSE: To evaluate the effectiveness of transrectal ultrasound-guided permanent radioactive (125)I implantation of the prostate for organ-confined adenocarcinoma of the prostate compared with historical data of prostatectomy and external beam radiotherap ... Full text Link to item Cite

SU‐FF‐J‐48: Three‐Dimensional MRI and Cone‐Beam CT Matching for Localization of Prostate Cancer Treatment

Conference Medical Physics · January 1, 2007 PURPOSES: There is a growing interest using MRI only for prostate cancer treatment planning. This study is aimed to investigate clinical feasibility of matching 3D planning MRI to on‐board cone‐beam CT (CBCT) images for target localization. Materials and M ... Full text Cite

On-line adaptive planning system for prostate IMRT treatment

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · January 1, 2007 Link to item Cite

SU‐FF‐J‐68: Dosimetric Comparison of Patient‐Specific Margins Vs. Uniform Margins for Prostate IMRT Treatments

Conference Medical Physics · January 1, 2007 Purpose: To evaluate the dosimetric improvement of IMRT treatment plans generated with patient‐specific margins compared to uniform margins for prostate cancer patients. Methods and Materials: For 13 prostate cancer patients who underwent IMRT treatment, d ... Full text Cite

Interstitial implant alone or in combination with external beam radiation therapy for intermediate-risk prostate cancer: a survey of practice patterns in the United States.

Journal Article Brachytherapy · 2007 PURPOSE: This study is aimed at understanding and defining the current patterns of care with respect to prostate brachytherapy for patients with intermediate-risk localized disease in the combined academic and community setting. METHODS AND MATERIALS: A no ... Full text Link to item Cite

The Merrick/Wallner/Butler et al article reviewed

Journal Article Oncology · December 1, 2006 Cite

Computer-based learning in medical education: a critical view.

Journal Article J Am Coll Radiol · October 2006 Featured Publication A number of reports in the past decade have concluded that the medical education system must be reformed. These reports often call for the incorporation of new technologies into the educational process. One technology that has found its way into the medica ... Full text Link to item Cite

Confidence intervals and survival estimates: a systematic review of 3 oncology journals.

Journal Article Am J Clin Oncol · August 2006 Featured Publication PURPOSE: Kaplan-Meier methods generate an estimate of survival when follow-up is less than complete. Confidence intervals (CI) provide a range of values that is likely to contain the true result. We hypothesized that reporting of CI around survival estimat ... Full text Link to item Cite

Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse of prostate cancer after definitive local therapy.

Journal Article Urology · June 2006 Featured Publication OBJECTIVES: To report a prospective trial of lycopene supplementation in biochemically relapsed prostate cancer. METHODS: A total of 36 men with biochemically relapsed prostate cancer were enrolled in a dose-escalating, Phase I-II trial of lycopene supplem ... Full text Link to item Cite

Update on brachytherapy in localized prostate cancer: the importance of dosimetry.

Journal Article Curr Opin Urol · May 2006 Featured Publication PURPOSE OF REVIEW: Prostate brachytherapy has become a common treatment modality for clinical localized adenocarcinoma of the prostate. This is the result of prostate screening and improved technology that currently allows for an outpatient procedure that ... Full text Link to item Cite

A phase II study of external beam radiotherapy combined with permanent source brachytherapy for intermediate-risk, clinically localized adenocarcinoma of the prostate: preliminary results of RTOG P-0019.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2006 Featured Publication PURPOSE: To estimate the rate of acute and late Grade 3-5 genitourinary and gastrointestinal toxicity after treatment with external beam radiotherapy and permanent source brachytherapy in a multi-institutional, cooperative group setting. METHODS AND MATERI ... Full text Link to item Cite

Percentage of positive biopsies associated with freedom from biochemical recurrence after low-dose-rate prostate brachytherapy alone for clinically localized prostate cancer.

Journal Article Urology · February 2006 Featured Publication OBJECTIVES: To examine the relationship between the percentage of positive biopsies (PPBs) and freedom from biochemical recurrence (FFBR) in men treated with low-dose-rate prostate brachytherapy (LDRPB) alone. The PPBs has been associated with FFBR in men ... Full text Link to item Cite

A descriptive analysis of postimplant dosimetric parameters from Radiation Therapy Oncology Group P0019.

Journal Article Brachytherapy · 2006 Featured Publication BACKGROUND: To date, there are few descriptive analyses of postimplant dosimetry from multi-institutional clinical trials. The purpose of this report is to describe the postimplant dosimetry achieved in Radiation Therapy Oncology Group (RTOG) 0019. METHODS ... Full text Link to item Cite

Lycopene dietary supplements and prostate cancer treatment

Journal Article Seminars in Preventive and Alternative Medicine · January 1, 2006 Lycopene is the predominant carotenoid in tomatoes and is responsible for their red color. There is substantial epidemiologic evidence that suggests a protective effect of increased tomato and/or lycopene consumption and the development of prostate cancer. ... Full text Cite

Redox-transmetalation process as a generalized synthetic strategy for core-shell magnetic nanoparticles.

Journal Article J Am Chem Soc · November 23, 2005 Although multicomponent core-shell type nanomaterials are one of the highly desired structural motifs due to their simultaneous multifunctionalities, the fabrication strategy for such nanostructures is still in a primitive stage. Here, we present a redox-t ... Full text Link to item Cite

Pthiriasis capitis.

Journal Article Int J Dermatol · September 2005 Full text Link to item Cite

Health-related quality of life in men receiving prostate brachytherapy on RTOG 98-05.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2005 Featured Publication PURPOSE: To prospectively assess health-related quality of life (HRQOL) during the first year after treatment with prostate brachytherapy (PB) alone for T1c-2a prostate cancer. MATERIALS AND METHODS: Ninety-eight patients from 24 institutions were eligible ... Full text Link to item Cite

Langmuir monolayers of Co nanoparticles and their patterning by microcontact printing.

Journal Article J Phys Chem B · July 14, 2005 In this paper, we describe an easy and reliable method for the production of patterned monolayers of Co nanoparticles. A two-dimensional monolayer of Co nanoparticles is fabricated by spreading a nanoparticle solution over an air-water interface and then t ... Full text Link to item Cite

Three tears for EMAS.

Journal Article Occupational medicine (Oxford, England) · June 2005 Cite

Percutaneous coronary intervention versus coronary artery bypass grafting for diabetics with multivessel coronary artery disease: the Korean Multicenter Revascularization Registry (KORR).

Journal Article J Korean Med Sci · April 2005 This study was designed to assess the relative merits of percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in multivessel coronary artery disease (MVCAD), particularly for Korean diabetics. Among 3,279 patients with MVCAD ... Full text Link to item Cite

Is NNT AOK?

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2005 Featured Publication Full text Link to item Cite

Plasmacellular differentiation in extranodal marginal zone B cell lymphomas of the ocular adnexa: an analysis of the neoplastic plasma cell phenotype and its prognostic significance in 136 cases.

Journal Article Br J Ophthalmol · March 2005 AIM: To determine (a) the expression of plasma cell related antigens in extranodal marginal zone B cell lymphomas (EMZL) of the ocular adnexa; and (b) the prognostic value of plasmacellular differentiation in these tumours. METHODS: A consecutive case seri ... Full text Link to item Cite

Dosimetric quantifiers for low-dose-rate prostate brachytherapy: is V(100) superior to D(90)?

Journal Article Brachytherapy · 2005 Featured Publication PURPOSE: The purpose of the present report is to describe the relationship between two dosimetric quantifiers (V(100) and D(90)) and freedom from biochemical recurrence (FFBR) in a cohort of men treated with low-dose-rate prostate brachytherapy (LDRPB) alo ... Full text Link to item Cite

Publication rate of abstracts from the annual ASTRO meeting: comparison with other organizations.

Journal Article J Am Coll Radiol · January 2005 PURPOSE: One of the explicit goals of the American Society of Therapeutic Radiology and Oncology (ASTRO) is to promote research and disseminate research results. In the past few years, ASTRO has required that manuscripts be submitted for publication for al ... Full text Link to item Cite

Dosimetry and cancer control after low-dose-rate prostate brachytherapy.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2005 PURPOSE: To describe the relationship between two commonly used dosimetric quantifiers (dose received by 90% of the prostate [D(90)] and volume receiving 100% of dose [V(100)]) and biochemical disease-free survival (bDFS) in a cohort of men treated with lo ... Full text Link to item Cite

Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1.

Journal Article J Cell Biochem · November 15, 2004 Early growth response-1 (Egr-1) is an immediate-early gene induced by E2 in the rodent uterus and breast cancer cells. E2 induces Egr-1 mRNA and protein levels in MCF-7 human breast cancer cells and reporter gene activity in cells transfected with pEgr-1A, ... Full text Link to item Cite

Transdermal delivery of macromolecules by erbium:YAG laser.

Journal Article J Control Release · November 5, 2004 The aim of this study was to assess the effect of molecular weight (MW) on the transdermal delivery of macromolecules by erbium:yttrium-aluminum-garnet (Er:YAG) laser treatment. Fluorescein isothiocyanate (FITC)-labeled dextran (FD) of increasing MWs (4.4, ... Full text Link to item Cite

Changes in graduate medical education: a view from radiation oncology.

Journal Article J Am Coll Radiol · August 2004 Featured Publication The accreditation process of graduate medical education is changing. This change presents new challenges to teachers of radiation oncology. With the help of the ACR and other institutions, radiation oncology is well positioned to meet this challenge. ... Full text Link to item Cite

Characterization of superparamagnetic "core-shell" nanoparticles and monitoring their anisotropic phase transition to ferromagnetic "solid solution" nanoalloys.

Journal Article J Am Chem Soc · July 28, 2004 The structure, magnetism, and phase transition of core-shell type CoPt nanoparticles en route to solid solution alloy nanostructures are systematically investigated. The characterization of Co(core)Pt(shell) nanoparticles obtained by a "redox transmetalati ... Full text Link to item Cite

Enhancement of topical 5-aminolaevulinic acid delivery by erbium:YAG laser and microdermabrasion: a comparison with iontophoresis and electroporation.

Journal Article Br J Dermatol · July 2004 BACKGROUND: 5-aminolaevulinic acid (ALA) is used as a protoporphyrin IX-precursor for the photodynamic therapy of superficial skin cancer and cutaneous metastases of internal malignancies. However, the permeability of hydrophilic ALA across the skin is ver ... Full text Link to item Cite

Cancer control after low-dose-rate prostate brachytherapy performed by a multidisciplinary team with no previous prostate brachytherapy experience.

Journal Article Urology · June 2004 Featured Publication OBJECTIVES: To describe the biochemical disease-free survival observed in the first cohort men treated by a multidisciplinary team of clinicians with no previous experience in low-dose-rate prostate brachytherapy (LDRPB). METHODS: The information in this r ... Full text Link to item Cite

Milium-like syringoma: a case study on histogenesis.

Journal Article J Cutan Pathol · April 2004 BACKGROUND: Milium-like syringoma is a variant of syringoma first described in 1987. Only few cases have been reported in the literature. It may be misleading clinically, and its histogenesis has not been clarified. CASE REPORT: We present a case of perior ... Full text Link to item Cite

Erbium:YAG laser pretreatment accelerates the response of Bowen's disease treated by topical 5-fluorouracil.

Journal Article Dermatol Surg · March 2004 BACKGROUND: Topical 5-fluorouracil (5-FU) is a standard treatment for Bowen's disease. However, its efficacy may be limited by the presence of stratum corneum. The Er:YAG laser has shown a dramatic enhancement effect on the delivery of 5-FU in vitro by abl ... Full text Link to item Cite

Prognostic value of cell-cycle markers in ocular adnexal lymphoma: an assessment of 230 cases.

Journal Article Graefes Arch Clin Exp Ophthalmol · February 2004 BACKGROUND: To determine the prognostic value of cell-cycle associated markers in ocular adnexal lymphoma (OAL). METHODS: Two hundred sixty-one consecutive cases of ocular adnexal lymphoproliferative lesions were subdivided into reactive lymphoid hyperplas ... Full text Link to item Cite

Re: Dosimetric consequences of increased seed strength for I-125 prostate implants. Radiother Oncol. 2003 Sep;68(3):295-7.

Journal Article Radiotherapy and Oncology Journal of the European Society for Therapeutic Radiology and Oncology · January 1, 2004 Full text Cite

Medical malpractice and prostate brachytherapy.

Journal Article Brachytherapy · 2004 Featured Publication Full text Link to item Cite

Permanent prostate brachytherapy: the significance of postimplant dosimetry.

Journal Article Rev Urol · 2004 Featured Publication Recent developments in imaging science and treatment-planning software allow for accurate postimplant dosimetric assessment in all patients after prostate brachytherapy. This article reviews the available data correlating cancer control and morbidity with ... Link to item Cite

Improved survival rates in sebaceous carcinoma of the eyelid.

Journal Article Eye (Lond) · January 2004 PURPOSE: To review the clinicopathological features, management, and survival rates for patients with sebaceous gland carcinoma of the eyelid, and to analyse the reasons for improved survival. METHODS: In the west of Scotland between 1975 and 2001, 32 case ... Full text Link to item Cite

In vitro efficacy of a polyhexamethylene biguanide-impregnated gauze dressing against bacteria found in veterinary patients.

Journal Article Vet Surg · 2004 OBJECTIVE: To evaluate the in vitro efficacy of polyhexamethylene biguanide (PHMB)-impregnated gauze dressing in limiting the growth of bacteria both within and underneath the dressing. STUDY DESIGN: In vitro study. METHODS: Squares of PHMB-impregnated and ... Full text Link to item Cite

Facile fabrication of 2-dimensional arrays of sub-10 nm single crystalline Si nanopillars using nanoparticle masks.

Journal Article Chem Commun (Camb) · December 21, 2003 A simple procedure for the fabrication of sub-10 nm scale Si nanopillars in a 2-D array using reactive ion etching with 8 nm Co nanoparticles as etch masks is demonstrated. The obtained Si nanopillars are single crystalline tapered pillar structures of 5 n ... Full text Link to item Cite

In regard to Ghaly et al., IJROBP 2003;55:1288-1293.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2003 Featured Publication Full text Link to item Cite

The 1999 patterns of care study of radiotherapy in localized prostate carcinoma: a comprehensive survey of prostate brachytherapy in the United States.

Journal Article Cancer · November 1, 2003 Featured Publication BACKGROUND: The objective of the current study was to provide descriptive information on a representative national sample of patients with prostate carcinoma who were treated with prostate brachytherapy (PB) in calendar year 1999. METHODS: A random survey ... Full text Link to item Cite

Increased transmigration of G-CSF-mobilized peripheral blood CD34+ cells after overnight storage at 37 degrees C.

Journal Article Transfusion · November 2003 BACKGROUND: G-CSF-mobilized PBPCs are utilized in allogeneic and autologous PBPC transplants. Homing, adhesion, and transmigration of hematopoietic CD34+ cells are required for successful engraftment. Hematopoietic CD34+ cells undergo directional migration ... Full text Link to item Cite

Lasers and microdermabrasion enhance and control topical delivery of vitamin C.

Journal Article J Invest Dermatol · November 2003 The objective of this study was to evaluate the ability of lasers and microdermabrasion, both of which are skin resurfacing modalities, to enhance and control the in vitro skin permeation and deposition of vitamin C. The topical delivery of magnesium ascor ... Full text Link to item Cite

Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade.

Journal Article J Cell Biochem · August 1, 2003 Flavonoids were demonstrated to possess several biological effects including antitumor, antioxidant, and anti-inflammatory activities in our previous studies. However, the effect of glycosylation on their biological functions is still undefined. In the pre ... Full text Link to item Cite

Histological and morphometric analysis of the effects of argon laser epilation.

Journal Article Br J Ophthalmol · August 2003 AIM: To analyse the location and extent of tissue damage induced after argon laser epilation. METHODS: Laser burns were applied to the lid margins of four patients before excision for entropion ("live tissue") and the lid margin of one patient was lasered ... Full text Link to item Cite

Myxoid leiomyoma of the iris in a dog.

Journal Article Vet Ophthalmol · June 2003 A leiomyoma of the iris is described in an 11-year-old Yorkshire Terrier. This is a rare primary intraocular tumor in dogs and we describe the clinical presentation, gross findings and histopathologic characteristics of this tumor. The diagnosis was made o ... Full text Link to item Cite

Characterization of multiple CD34+ cell populations in cord blood.

Journal Article J Hematother Stem Cell Res · April 2003 Unlike granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood, which show a single homogeneous population of CD34(+) cells, umbilical cord blood (CB) CD34(+) cells are present as multiple populations, CD34(regular) and CD34(bright) (the l ... Full text Link to item Cite

A structured literature review to determine the use of the American Society for Therapeutic Radiology and Oncology consensus definition of biochemical failure.

Journal Article Urology · February 2003 Featured Publication OBJECTIVES: The American Society for Therapeutic Radiology and Oncology consensus definition (ACD) of biochemical failure after radiotherapy for prostate cancer requires three consecutive prostate-specific antigen increases from a nadir value. The members ... Full text Link to item Cite

Predictors of positive head-up tilt test in patients with suspected neurocardiogenic syncope or presyncope.

Journal Article Pacing Clin Electrophysiol · February 2003 Neurocardiogenic syncope is the most common cause of syncope in patients who present in outpatient clinics. Head-up tilt test (HUT) has been widely used to diagnose neurocardiogenic syncope. However, the HUT does not always produce a positive response in p ... Full text Link to item Cite

Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production.

Journal Article Biochem Pharmacol · December 15, 2002 Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is an active constituent of Rheum palmatum, and showed inhibitory activity on lipopolysaccharide-induced NO production in our previous study. However, the apoptosis-inducing activity of emodin has remained un ... Full text Link to item Cite

Radioactive sources embedded in suture are associated with improved postimplant dosimetry in men treated with prostate brachytherapy.

Journal Article Radiother Oncol · November 2002 Featured Publication BACKGROUND AND PURPOSE: Reports using the retropubic and transperineal technique of prostate brachytherapy suggest that adequate radiation doses are required for good clinical results with I-125. After 3 years of using loose sources (LS), radioactive sourc ... Full text Link to item Cite

Interobserver variability leads to significant differences in quantifiers of prostate implant adequacy.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2002 Featured Publication PURPOSE: To compare the prostate gland volumes and subsequent quantifiers of implant adequacy determined by five separate brachytherapists on postimplant CT images performed 1 day after prostate brachytherapy. METHODS AND MATERIALS: Ten consecutive patient ... Full text Link to item Cite

Coexistence of localized Langerhans cell histiocytosis and cutaneous Rosai-Dorfman disease.

Journal Article Br J Dermatol · October 2002 Rosai-Dorfman disease (RDD; sinus histiocytosis with massive lymphadenopathy) and Langerhans cell histiocytosis (LCH) are two different yet pathogenetically related histiocytic disorders. While systemic and localized forms have been identified in both dise ... Full text Link to item Cite

Flavanones structure-related inhibition on TPA-induced tumor promotion through suppression of extracellular signal-regulated protein kinases: involvement of prostaglandin E2 in anti-promotive process.

Journal Article J Cell Physiol · October 2002 Biological functions of flavanones have been studied extensively, however, the structure-related activities of flavanones on 12-o-tetradecanoylphorbol 13-acetate (TPA)-induced promotive effects are still unclear. In this study, flavanone, 2'-OH flavanone, ... Full text Link to item Cite

The role of androgen deprivation therapy combined with prostate brachytherapy.

Journal Article Urology · September 2002 Featured Publication Several prospective randomized clinical trials have demonstrated improved outcomes in men receiving androgen deprivation therapy (ADT) in combination with definitive local therapy (external-beam radiotherapy or surgery). ADT is commonly combined with prost ... Full text Link to item Cite

Quality of life after prostate cancer treatment.

Journal Article J Clin Oncol · July 1, 2002 Featured Publication Full text Link to item Cite

The effect of laser treatment on skin to enhance and control transdermal delivery of 5-fluorouracil.

Journal Article J Pharm Sci · July 2002 The effect of three lasers (i.e., the ruby, erbium:YAG, and CO2) on the ability to enhance and control skin permeation of 5-fluorouracil (5-FU) was studied in vitro. Light microscopic and ultrastructural (scanning electron microscopic) changes in the nude ... Full text Link to item Cite

In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production.

Journal Article Eur J Pharmacol · June 20, 2002 Flavonoids are widely distributed in plants, but their biological functions are still unclear. In the present study, in vitro and in vivo experiments were performed to demonstrate the inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccha ... Full text Link to item Cite

Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.

Journal Article Arch Toxicol · June 2002 Wogonin and fisetin are flavonoids, which are widely distributed in plants. Our recent study demonstrated that, among seven structurally related flavonoids, wogonin and fisetin showed the most potent apoptosis-inducing activities in human promyeloleukemic ... Full text Link to item Cite

Epidemiology of 21-hydroxylase deficiency in Singapore.

Journal Article J Pediatr Endocrinol Metab · April 2002 We report the incidence and epidemiology of 21-hydroxylase deficiency in Singapore, based on a retrospective study of all known patients diagnosed with classical 21-hydroxylase deficiency in the past 21 years. The database was obtained from the case regist ... Full text Link to item Cite

Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease.

Journal Article Biochem Pharmacol · January 15, 2002 Seven structurally related flavonoids including luteolin, nobiletin, wogonin, baicalein, apigenin, myricetin and fisetin were used to study their biological activities on the human leukemia cell line, HL-60. On MTT assay, wogonin, baicalein, apigenin, myri ... Full text Link to item Cite

Radiation dose to the neurovascular bundles or penile bulb does not predict erectile dysfunction after prostate brachytherapy.

Journal Article Brachytherapy · 2002 Featured Publication PURPOSE: To examine the relationship between calculated doses to the neurovascular bundles (NVBs) and the penile bulb (PB) and the development of erectile dysfunction (ED) after low-dose-rate prostate brachytherapy (LDRPB) alone. METHODS AND MATERIALS: Bet ... Full text Link to item Cite

Nitric oxide and prostaglandin E2 participate in lipopolysaccharide/interferon-gamma-induced heme oxygenase 1 and prevent RAW264.7 macrophages from UV-irradiation-induced cell death.

Journal Article J Cell Biochem · 2002 Induction of heme oxygenase (HO)-1 during inflammation has been demonstrated in many cell types, but the contribution of inflammatory molecules nitric oxide (NO) and prostaglandin E(2) (PGE(2)) has remained unresolved. Here we show that NO donors including ... Full text Link to item Cite

A prospective quality-of-life study in men with clinically localized prostate carcinoma treated with radical prostatectomy, external beam radiotherapy, or interstitial brachytherapy.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2001 PURPOSE: To prospectively assess the health-related quality of life (HRQOL) and changes in HRQOL during the first year after 3 different treatments for clinically localized prostate cancer. METHODS AND MATERIALS: Ninety men with T1-T2 adenocarcinoma of the ... Full text Link to item Cite

The status of diabetes mellitus in primary care institution and restructured hospitals in Singapore.

Journal Article Singapore medical journal · November 2001 The Diabcare-Asia Singapore 1998 project was carried out using data from 22 centres collected on paper forms to provide an overview of diabetes management and metabolic control status in 1697 diabetic patients from both primary health care clinic (PHC) (67 ... Cite

A window on the current status of diabetes mellitus in Singapore--the Diabcare-Singapore 1998 study.

Journal Article Singapore medical journal · November 2001 The Diabcare-Singapore project was carried out in 22 clinics (general hospitals, GH and primary healthcare centres, PHC) to provide an overview of diabetes management and metabolic control status. Data from 1697 diabetic patients were collected on paper fo ... Cite

Transdermal drug delivery enhanced and controlled by erbium:YAG laser: a comparative study of lipophilic and hydrophilic drugs.

Journal Article J Control Release · July 10, 2001 The influence of an erbium:YAG laser on the transdermal delivery of drugs across skin was studied in vitro. Indomethacin and nalbuphine, which have the same molecular weight, were selected as model lipophilic and hydrophilic drugs, respectively, to compare ... Full text Link to item Cite

Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells.

Journal Article Eur J Cell Biol · March 2001 We have investigated the regulation mechanism of chemical stress-induced HSP70 gene expression in human colorectal carcinoma cells (COLO205 and HT29). Our data show that chemical treatments including sodium arsenite and curcumin, induced significant synthe ... Full text Link to item Cite

Usefulness of diabetic retinopathy as a marker of risk for thallium myocardial perfusion defects in non-insulin-dependent diabetes mellitus.

Journal Article Am J Cardiol · February 15, 2001 Among 236 non-insulin-dependent diabetics with clinically suspected coronary artery disease, the rate of thallium-201 myocardial perfusion defects was significantly higher in subjects with (40.6%) than without (22.1%) diabetic retinopathy. Retinopathy was ... Full text Link to item Cite

Outcomes Committee

Journal Article International Journal of Radiation Oncology Biology Physics · January 1, 2001 Full text Cite

Radiation Therapy Oncology Group. Research Plan 2002-2006. Genitourinary Cancer Committee.

Journal Article International journal of radiation oncology, biology, physics · 2001 Cite

Radiation Therapy Oncology Group. Research Plan 2002-2006. Outcomes Committee.

Journal Article International Journal of Radiation Oncology Biology Physics · 2001 Cite

Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages.

Journal Article J Cell Biochem · 2001 Several natural flavonoids have been demonstrated to perform some beneficial biological activities, however, higher-effective concentrations and poor-absorptive efficacy in body of flavonoids blocked their practical applications. In the present study, we p ... Full text Link to item Cite

Iodine-123 MIBG imaging before treatment of heart failure with carvedilol to predict improvement of left ventricular function and exercise capacity.

Journal Article J Nucl Cardiol · 2001 BACKGROUND: We examined whether cardiac sympathetic imaging with iodine-123 metaiodobenzylguanidine (MIBG) would predict improvement of left ventricular (LV) function and exercise capacity in patients with heart failure after treatment with carvedilol. MET ... Full text Link to item Cite

Effect of mutagen-induced cell lethality on the dose response of germline mutations.

Journal Article Environ Mol Mutagen · 2001 Molecular tests for mutations require a sample of tissue from which DNA is extracted, to determine the presence or absence of one or more mutations per sample. To ensure mutation fixation each sample must consist of an equal number of cells that have had o ... Full text Link to item Cite

Dipyridamole myocardial SPECT with low heart rate response indicates cardiac autonomic dysfunction in patients with diabetes.

Journal Article J Nucl Cardiol · 2001 BACKGROUND: Because dipyridamole is used to assess heart rate (HR) variability, we investigated whether a low HR response during dipyridamole single photon emission computed tomography (SPECT) in patients with diabetes indicates the presence of cardiac aut ... Full text Link to item Cite

Decreased entropy of symbolic heart rate dynamics during daily activity as a predictor of positive head-up tilt test in patients with alleged neurocardiogenic syncope.

Journal Article Phys Med Biol · November 2000 Entropy measures of RR interval variability during daily activity over a 24h period were compared in 30 patients with a positive head-up tilt (HUT) test and 30 patients with a negative HUT test who had a history of alleged neurocardiogenic syncope. Two dif ... Full text Link to item Cite

The changing demography of diabetes mellitus in Singapore.

Journal Article Diabetes Res Clin Pract · October 2000 Diabetes mellitus has been on the rise in Singapore, while Singaporeans are becoming more affluent, our lifestyles are more sedentary and our population is ageing rapidly. The prevalence of diabetes mellitus rose from 2% in 1975 to 4.7% in 1984, 8.6% in 19 ... Full text Link to item Cite

Transformation of cell type in uveal melanomas: a quantitative histologic analysis.

Journal Article Arch Ophthalmol · October 2000 OBJECTIVE: To describe the cytologic transformation and tumor progression in a series of uveal melanomas. METHODS: Fifteen cases of uveal melanoma, treated by primary transscleral local resection without primary adjuvant treatment, needed enucleation becau ... Full text Link to item Cite

Regarding Mohan, Kuplian, and Willoughby, IJROBP 2000;46:575-580.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2000 Full text Link to item Cite

Takayasu's arteritis: assessment of disease activity with contrast-enhanced MR imaging.

Journal Article AJR Am J Roentgenol · August 2000 OBJECTIVE: The purpose of this study was to evaluate the role of contrast-enhanced MR imaging in the determination of disease activity in patients with Takayasu's arteritis. SUBJECTS AND METHODS: High-resolution contrast-enhanced T1-weighted spinecho MR im ... Full text Link to item Cite

Prevalence and risk factors of silent cerebral infarction in apparently normal adults.

Journal Article Hypertension · July 2000 Cerebrovascular disease is a major cause of death and disability in adults. Silent cerebral infarction (SCI) portends more severe cerebral infarctions or may lead to insidious progressive brain damage resulting in vascular dementia. This study was designed ... Full text Link to item Cite

A prospective analysis of patient-reported quality of life after prostate brachytherapy.

Journal Article Semin Urol Oncol · May 2000 The purpose of this study was to prospectively assess the patient-reported quality of life (QOL) and changes in QOL during the first 3 months after prostate brachytherapy (PB). Seventy-four men treated with PB between September 1997 and December 1998 compl ... Link to item Cite

Retinal vasoproliferative tumors: surgical management and histological findings.

Journal Article Arch Ophthalmol · April 2000 Vascular masses occurring in the peripheral retina have been described extensively in the literature. Many terms, including "presumed acquired hemangiomas," "hemangioma-like," "angiomatous masses," "angioma-like," "peripheral retinal telangiectasis," and " ... Full text Link to item Cite

Oncogenic base substitution mutations in circulating leukocytes of normal individuals.

Journal Article Cancer Res · April 1, 2000 The background frequency of mutations in human tissues is an important issue in cancer susceptibility and genotoxic exposure determinations. Here we report the detection of rare mutant leukocytes containing oncogenic base substitutions of the Harvey-ras, N ... Link to item Cite

A preliminary analysis of health-related quality of life in the first year after permanent source interstitial brachytherapy (PIB) for clinically localized prostate cancer.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2000 PURPOSE: To prospectively assess the health-related quality of life (HRQOL) and changes in HRQOL during the first year after permanent source interstitial brachytherapy (PIB). METHODS AND MATERIALS: Thirty-one men treated with PIB between September 1997 an ... Full text Link to item Cite

Postimplant analysis of transperineal interstitial permanent prostate brachytherapy: evidence for a learning curve in the first year at a single institution.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2000 PURPOSE: The utilization of transperineal interstitial permanent prostate brachytherapy (TIPPB) is increasing in the United States. Quality assessment of TIPPB is in its infancy, and to date, dosimetric analyses have only been reported from centers with a ... Full text Link to item Cite

Myocardial injury-induced fibroblast proliferation facilitates retroviral-mediated gene transfer to the rat heart in vivo.

Journal Article J Gene Med · 2000 BACKGROUND: Efficient and stable transfer of therapeutic DNA into injured myocardium would be an initial step towards a genetic treatment aimed at myocardial repair after myocardial infarction. Proliferating cardiac fibroblasts in the healing myocardium co ... Full text Link to item Cite

Penile length of newborns in Singapore.

Journal Article J Pediatr Endocrinol Metab · January 2000 Micropenis is an important sign in congenital hypopituitarism and various disorders. Documented norms for penile length exist only for babies of Caucasian and Middle-Eastern origin. This study was carried out to establish such norms for Asian newborns. We ... Full text Link to item Cite

Aging affects the association between endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction in the Korean male population.

Journal Article Korean J Intern Med · January 2000 OBJECTIVES: The aging process affects responsiveness and other functions of endothelium and vascular smooth muscle cells, predisposing the old vessels to the development of atherosclerotic lesions. Endothelial nitric oxide synthase (ecNOS) gene polymorphis ... Full text Link to item Cite

Takayasu arteritis: diagnosis with MR imaging and MR angiography in acute and chronic active stages.

Journal Article J Magn Reson Imaging · November 1999 Early diagnosis and treatment of Takayasu arteritis is important in prevention of serious complications. Spin-echo magnetic resonance imaging (MRI) can depict early wall thickening of the aorta and cine MRI can evaluate aortic valve function. Significant e ... Full text Link to item Cite

T-cell and T/natural killer-cell lymphomas involving ocular and ocular adnexal tissues: a clinicopathologic, immunohistochemical, and molecular study of seven cases.

Journal Article Ophthalmology · November 1999 OBJECTIVE: Lymphomas of the eye and its adnexa are frequently of B lineage. This study aims to characterize the clinical and histopathologic features of the rare non-B-cell non-Hodgkin lymphomas (NHL) of these locations. DESIGN: Retrospective, noncomparati ... Full text Link to item Cite

Angiotensin II stimulates proliferation of adventitial fibroblasts cultured from rat aortic explants.

Journal Article J Korean Med Sci · October 1999 It has been proposed that the local renin-angiotensin system is activated in the adventitia after vascular injury. However, the physiological role of Angiotensin II (Ang II) in the adventitia has not been studied at a cellular level. This study was designe ... Full text Link to item Cite

Idiopathic intracranial hypertension: a case report with optic nerve histopathology.

Journal Article J Neuroophthalmol · September 1999 We present the clinical and pathologic findings in an atypical case of idiopathic intracranial hypertension. A 51-year-old man had headaches, visual deterioration, papilloedema, and deafness. Neuroimaging was normal, and cerebrospinal fluid pressure monito ... Link to item Cite

Early quality of life assessment in men treated with permanent source interstitial brachytherapy for clinically localized prostate cancer.

Journal Article J Urol · August 1999 PURPOSE: We prospectively assessed quality of life changes with time using validated instruments in men with clinically localized prostate cancer treated with permanent source interstitial brachytherapy. MATERIALS AND METHODS: A total of 46 men consecutive ... Link to item Cite

Recent advances in the treatment of prostate cancer.

Journal Article Ann Oncol · August 1999 As new evidence for prostate cancer treatment has emerged in the last few years, longstanding controversies in the treatment of prostate cancer have resurfaced. A number of long-held tenets of prostate cancer therapy have been revisited, sometimes with sur ... Full text Link to item Cite

Needle-in-a-haystack detection and identification of base substitution mutations in human tissues.

Journal Article Mutat Res · August 1999 Background and induced germline mutagenesis and other genotoxicity studies have been hampered by the lack of a sufficiently sensitive technique for detecting mutations in a small cluster of cells or a single cell in a tissue sample composed of millions of ... Full text Link to item Cite

Moderate hyperhomocyst(e)inemia is associated with the presence of coronary artery disease and the severity of coronary atherosclerosis in Koreans.

Journal Article Thromb Res · April 1, 1999 To examine whether moderate hyperhomocyst(e)inemia is associated with coronary artery disease and the number of diseased coronary vessels in Koreans, we investigated 201 patients with angiographically documented coronary artery disease and 187 healthy subj ... Full text Link to item Cite

Immunohistochemical examination of an orbital alveolar soft part sarcoma.

Journal Article Graefes Arch Clin Exp Ophthalmol · April 1999 BACKGROUND: A 32 year-old male patient had a 6-week history of left-sided proptosis. Computer tomography revealed a 16x15x15 mm smooth and well-defined mass between the optic nerve and the medial and superior rectus muscles in the left orbit. METHODS: The ... Full text Link to item Cite

Dimorphic immunohistochemical staining in ocular sebaceous neoplasms: a useful diagnostic aid.

Journal Article Eye (Lond) · 1999 PURPOSE: We studied whether patterns of immunostaining in formalin-fixed, paraffin-embedded tissue could help to distinguish between sebaceous neoplasms of the eyelid and other eyelid neoplasms. METHODS: We applied antibodies to human milk fat globule-1 (H ... Full text Link to item Cite

Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma: a secondary analysis of RTOG 85-27.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 1998 PURPOSE: The purpose of the present study is to investigate the strength of association between anemia and overall survival, locoregional failure, and late radiation therapy (RT) complications in a large prospective study of patients with advanced head and ... Full text Link to item Cite

Phase III trial of neoadjuvant chemotherapy in patients with invasive bladder cancer treated with selective bladder preservation by combined radiation therapy and chemotherapy: initial results of Radiation Therapy Oncology Group 89-03.

Journal Article J Clin Oncol · November 1998 PURPOSE: To assess the efficacy of neoadjuvant methotrexate, cisplatin, and vinblastine (MCV) chemotherapy in patients with muscle-invading bladder cancer treated with selective bladder preservation. PATIENTS AND METHODS: One hundred twenty-three eligible ... Full text Link to item Cite

Magnetic resonance imaging diagnosis of Takayasu arteritis.

Journal Article Int J Cardiol · October 1, 1998 Conventional angiography has been used for diagnosis of Takayasu arteritis (TA). In early stage of TA, subtle inflammatory wall thickening of the aorta and its branches without significant stenosis may be the only morphologic change of TA. Magnetic resonan ... Full text Link to item Cite

Lymphoproliferative lesions of the ocular adnexa. Analysis of 112 cases.

Journal Article Ophthalmology · August 1998 OBJECTIVE: Lymphoproliferative lesions of the ocular adnexa were analyzed to examine (1) the suitability of the Revised European-American Lymphoma (REAL) classification for the subtyping of the lymphomas in these sites; (2) the predictive value of the REAL ... Full text Link to item Cite

Myolipoma of the eyelid.

Journal Article Graefes Arch Clin Exp Ophthalmol · August 1998 BACKGROUND: This report describes the pathology of a myolipoma which occurred in the eyelid. Myolipoma is a benign hamartomatous tumour in which smooth muscle cells are interspersed with adipocytes. PATIENT DETAILS: An irregular yellowish tumour (30 x 25 m ... Full text Link to item Cite

Trevor lloyd davies

Journal Article BMJ (Clinical research ed.) · July 1998 Cite

Pheochromocytoma complicated with cardiomyopathy after delivery--a case report and literature review.

Journal Article Korean J Intern Med · July 1998 Pheochromocytoma in pregnancy is very rare but it is associated with very high maternal and fetal mortality. Therefore, it is important to include pheochromocytoma in the differential diagnosis of hypertension associated with pregnancy. It is difficult to ... Full text Link to item Cite

Left main coronary artery dissection after blunt chest trauma presented as acute anterior myocardial infarction: assessment by intravascular ultrasound: a case report.

Journal Article Journal of Korean medical science · June 1998 Coronary artery injury after blunt chest trauma is very rare, but this can result in a serious acute myocardial infarction. Coronary artery dissection is an uncommon complication of thoracic injuries. We report a case of a 17-year-old male who was presente ... Cite

Keratoacanthoma of the bulbar conjunctiva.

Journal Article Br J Ophthalmol · May 1998 Full text Link to item Cite

Pleomorphic fibroma of the eyelid.

Journal Article Graefes Arch Clin Exp Ophthalmol · May 1998 BACKGROUND: This report describes the pathology of an unusual variant of fibroma of the eyelid. The soft ovoid tumour was excised from the centre of the left lower lid in an 84-year-old patient had been growing slowly for several years. METHODS: The tumour ... Full text Link to item Cite

Distribution of antioxidant enzymes in the normal aged human conjunctiva: an immunocytochemical study.

Journal Article Graefes Arch Clin Exp Ophthalmol · February 1998 BACKGROUND: The purpose of the study was to map the precise location of four antioxidant enzymes in the normal human conjunctiva. METHODS: Conjunctival tissue (seventeen specimens) from seven patients was processed for light microscopy and immunogold elect ... Full text Link to item Cite

Gating provides improved accuracy for differentiating artifacts from true lesions in equivocal fixed defects on technetium 99m tetrofosmin perfusion SPECT.

Journal Article J Nucl Cardiol · 1998 BACKGROUND: Because equivocal fixed perfusion defects on single photon emission computed tomography (SPECT) often cause a diagnostic dilemma in patients with suspected coronary artery disease (CAD), we used receiver-operating characteristic (ROC) curve ana ... Full text Link to item Cite

The developmental basis for germline mosaicism in mouse and Drosophila melanogaster.

Journal Article Genetica · 1998 Data involving germline mosaics in Drosophila melanogaster and mouse are reconciled with developmental observations. Mutations that become fixed in the early embryo before separation of soma from the germline may, by the sampling process of development, co ... Link to item Cite

Anti-GAD antibodies in Chinese patients with youth and adult-onset IDDM and NIDDM.

Journal Article Diabetologia · December 1997 An autoimmune basis for the pathogenesis of insulin-dependent diabetes mellitus (IDDM) is supported by the frequent presence of autoantibodies - islet cell antibodies (ICAs) and GAD antibodies (GADab). However, in Chinese patients with clinical IDDM, a low ... Full text Link to item Cite

Polymorphism of angiotensin converting enzyme gene is associated with circulating levels of plasminogen activator inhibitor-1.

Journal Article Arterioscler Thromb Vasc Biol · November 1997 The deletion (D) allele of the insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene is strongly associated with an increased level of circulating ACE. The ACE gene polymorphism may influence the production of angiotensin II ... Full text Link to item Cite

Microvilli elongate in response to hydrogen peroxide and to perturbations of intracellular calcium.

Journal Article Exp Cell Res · October 10, 1997 Using scanning electron microscopy and fluorescence microscopy, we have found that apical microvilli of diverse cell types, including nonepithelial cells, elongate in culture in response to the oxidative stress of hydrogen peroxide. The microvilli induced ... Full text Link to item Cite

A histologic study (including DNA quantification and Ki-67 labeling index) in uveal melanomas after brachytherapy with ruthenium plaques.

Journal Article Invest Ophthalmol Vis Sci · September 1997 PURPOSE: To investigate the proliferative potential and DNA damage in uveal melanomas treated by brachytherapy. METHODS: Forty-two enucleated eyes that had been treated with 106Ru/106Rh radioactive plaques for uveal melanoma were subgrouped according to th ... Link to item Cite

A novel pattern of oculocerebral malformation.

Journal Article Br J Ophthalmol · June 1997 AIMS/BACKGROUND: To report a novel pattern of oculocerebral malformation related to the group of diseases characterised by cobblestone lissencephaly. METHODS: By means of a case report with specialist descriptions of the novel neuropathological and ophthal ... Full text Link to item Cite

Initial clinical assessment of CT-MRI image fusion software in localization of the prostate for 3D conformal radiation therapy.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 1997 PURPOSE: To assess the utility of image fusion software and compare MRI prostate localization with CT localization in patients undergoing 3D conformal radiation therapy of prostate cancer. MATERIALS AND METHODS: After a phantom study was performed to ensur ... Full text Link to item Cite

Neck failure in T2N0 squamous cell carcinoma of the true vocal cords: the Fox Chase experience and review of the literature.

Journal Article Am J Clin Oncol · April 1997 There is a need for additional data in the literature regarding elective nodal irradiation in the treatment of T2N0 squamous cell carcinoma of the glottic larynx. We examined the experience at the Fox Chase Cancer Center and performed a literature review i ... Full text Link to item Cite

Cardiac tamponade due to a rupture of the coronary arteriovenous aneurysm--a case report.

Journal Article Journal of Korean medical science · April 1997 We experienced an unusual case of cardiac tamponde caused by a rupture of the coronary arteriovenous aneurysm in a 54-year-old woman. The patient was suffered from sudden chest pain and syncope, and was initially managed by pericardiocentesis following an ... Cite

Optimization of conformal radiation treatment of prostate cancer: report of a dose escalation study.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 1997 PURPOSE: The development of conformal radiation technique including improved patient immobilization has allowed us to test the value of dose escalation in optimizing the radiation treatment of prostate cancer. METHODS AND MATERIALS: Outcome is reported for ... Full text Link to item Cite

Evidence of increased failure in the treatment of prostate carcinoma patients who have perineural invasion treated with three-dimensional conformal radiation therapy.

Journal Article Cancer · January 1, 1997 BACKGROUND: The detection of perineural invasion (PNI) in the diagnostic transrectal biopsy of the prostate is associated with a 93% frequency of extracapsular disease extension in patients treated by prostatectomy for adenocarcinoma of the prostate. Extra ... Full text Link to item Cite

Late GI and GU complications in the treatment of prostate cancer.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 1997 PURPOSE: To assess the factors that predict late GI and GU morbidity in radiation treatment of the prostate. METHODS AND MATERIALS: Seven hundred twelve consecutive prostate cancer patients treated at this institution between 1986 and 1994 (inclusive) with ... Full text Link to item Cite

Increasing prostate-specific antigen profile following definitive radiation therapy for localized prostate cancer: clinical observations.

Journal Article J Clin Oncol · January 1997 PURPOSE: To examine the natural history of patients who have received definitive radiation therapy alone for clinically localized prostate cancer and have an increasing prostate-specific antigen (PSA) profile. PATIENTS AND METHODS: One hundred fifty-one me ... Full text Link to item Cite

Changing indications for penetrating keratoplasty in the west of Scotland from 1970 to 1995.

Journal Article Eye (Lond) · 1997 In an attempt to predict the trends which might occur in the changing patterns of corneal surgery in the next decade and hence the financial implications, a retrospective study of the treatment of corneal disease was carried out using the pathological repo ... Full text Link to item Cite

Short communication: CT-MRI image fusion for 3D conformal prostate radiotherapy: use in patients with altered pelvic anatomy.

Journal Article Br J Radiol · December 1996 We describe the application of CT-MRI fusion software for 3D conformal radiotherapy in two patients with localized prostate cancer who had significantly altered pelvic anatomy due to prior surgery. Patient A had a hemipelvectomy for fibrosarcoma and Patien ... Full text Link to item Cite

Keratokyphosis in rabbits: a functional and morphologic study.

Journal Article Cornea · November 1996 Keratokyphosis, a "nonfreeze keratomileusis" procedure, was applied in rabbits. The refractive changes were -6.5 +/- 0.7 (SD), -9.5 +/- 2.6, and -13.0 +/- 3.2 D for convex applanation surfaces with a vertex of +100 microns, +125 microns, and +150 microns i ... Link to item Cite

Multidrug resistance in ocular melanoma.

Journal Article Br J Ophthalmol · November 1996 AIMS/BACKGROUND: Metastatic disease in patients with ocular melanoma is resistant to chemotherapy. One of the main mechanisms of modulating multidrug resistance is the expression of the multidrug resistance gene 1 (MDR1) product (p-glycoprotein) by tumour ... Full text Link to item Cite

Prostate specific antigen nadir following external beam radiation therapy for clinically localized prostate cancer: the relationship between nadir level and disease-free survival.

Journal Article The Journal of urology · August 1996 PURPOSE: We determined whether the prostate specific antigen (PSA) nadir achieved following external beam radiation therapy alone predicts biochemical disease-free survival in a large cohort of men with clinically localized prostate cancer. MATERIALS AND M ... Cite

Prostate specific antigen nadir following external beam radiation therapy for clinically localized prostate cancer: the relationship between nadir level and disease-free survival.

Journal Article J Urol · August 1996 PURPOSE: We determined whether the prostate specific antigen (PSA) nadir achieved following external beam radiation therapy alone predicts biochemical disease-free survival in a large cohort of men with clinically localized prostate cancer. MATERIALS AND M ... Full text Link to item Cite

Conformal technique dose escalation for prostate cancer: biochemical evidence of improved cancer control with higher doses in patients with pretreatment prostate-specific antigen > or = 10 NG/ML.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 1996 PURPOSE: Conformal radiation technology results in fewer late complications and allows testing of the value of higher doses in prostate cancer. METHODS AND MATERIALS: We report the biochemical freedom from disease (bNED) rates (bNED failure is Prostate Spe ... Full text Link to item Cite

Urinary incontinence following external-beam radiotherapy for clinically localized prostate cancer.

Journal Article Urology · July 1996 OBJECTIVES: To determine the incidence of urinary incontinence in men with prostate cancer treated with definitive external-beam radiation therapy and to analyze the impact of various patient and treatment variables on the development of urinary incontinen ... Full text Link to item Cite

Erratum to Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells' [Mutation Res. 331 (1995) 213-224].

Journal Article Mutation research · July 1996 The 2-chloroethyl methanesulfonate (2CIEMS)-induced alcohol dehydrogenase (Adh) null germline mutation frequency in treated Drosophila melanogaster second instar larval gonia was two orders of magnitude greater than the spontaneous mutation frequency. DNA ... Cite

Metastatic choroidal melanoma to the contralateral orbit 40 years after enucleation.

Journal Article Arch Ophthalmol · June 1996 Metastatic uveal melanoma to the contralateral orbit is extremely rare, with only eight cases in the literature having been reported. We reviewed the clinical presentation, the histologic findings of the primary and secondary tumors, and the clinical outco ... Full text Link to item Cite

Lateral rectal shielding reduces late rectal morbidity following high dose three-dimensional conformal radiation therapy for clinically localized prostate cancer: further evidence for a significant dose effect.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 1996 PURPOSE: Using conventional treatment methods for the treatment of clinically localized prostate cancer central axis doses must be limited to 65-70 Gray (Gy) to prevent significant damage to nearby normal tissues. A fundamental hypothesis of three-dimensio ... Full text Link to item Cite

Young patients with prostate cancer have an outcome justifying their treatment with external beam radiation.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 1996 PURPOSE: The majority of young patients with early stage prostate cancer in the United States are treated with radical prostatectomy. To determine whether this preference for surgical care is justified, we analyzed by patient age the survival without bioch ... Full text Link to item Cite

Do the results of systematic biopsies predict outcome in patients with T1-T2 prostate cancer treated with radiation therapy alone?

Journal Article Urology · May 1996 OBJECTIVES: The present study examines whether findings from systematic biopsies add any prognostic information in men with clinical Stage T1-T2 prostate cancer treated with external beam radiation therapy alone. METHODS: Seventy-two men with clinical T1-T ... Full text Link to item Cite

Prostate carcinoma patients upstaged by imaging and treated with irradiation. An outcome-based analysis.

Journal Article Cancer · April 1, 1996 BACKGROUND: The American Joint Committee on Cancer (AJCC) staging of prostate cancer relies upon digital rectal examination (DRE) findings, but suggests using all available information, including prostate imaging studies, prior to definitive treatment of p ... Full text Link to item Cite

Patterns-of-failure analysis of patients with high pretreatment prostate-specific antigen levels treated by radiation therapy: the need for improved systemic and locoregional treatment.

Journal Article J Clin Oncol · April 1996 PURPOSE: The patterns of failure (local and/or regional v metastatic) have been determined for patients with prostate cancer and pretreatment prostate-specific antigen (PSA) levels > or = 20 ng/mL treated with radiation alone with the purpose to design app ... Full text Link to item Cite

Do overall treatment time, field size, and treatment energy influence local control of T1-T2 squamous cell carcinomas of the glottic larynx?

Journal Article Int J Radiat Oncol Biol Phys · March 1, 1996 PURPOSE: To evaluate treatment and patient related prognostic factors that may influence local control in the treatment of T1-T2 squamous cell carcinoma of the glottic larynx. METHODS AND MATERIALS: One hundred nine patients with invasive, previously untre ... Full text Link to item Cite

Ocular tumoral calcinosis. A clinicopathologic study.

Journal Article Arch Ophthalmol · March 1996 Tumoral calcinosis is a rare systemic disorder characterized by para-articular ectopic soft-tissue calcification. This case report describes the ophthalmic features (palpebral conjunctival calcific nodules, the white limbal girdle of Vogt, disc drusen, and ... Full text Link to item Cite

Amebic keratitis in a wearer of disposable contact lenses due to a mixed Vahlkampfia and Hartmannella infection.

Journal Article Ophthalmology · March 1996 PURPOSE: To support the hypothesis that Acanthamoeba is not a unique cause of amebic keratitis, we report a case of amebic keratitis in which viable Acanthamoeba could not be isolated from corneal tissue. Vahlkampfia and Hartmannella, two other genera of f ... Full text Link to item Cite

Pretreatment prostate-specific antigen doubling times: clinical utility of this predictor of prostate cancer behavior.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 1996 PURPOSE: The distribution of pretreatment and posttreatment prostate specific antigen (PSA) doubling times (PSADT) varies widely. This report examines the pretreatment PSADT as an independent predictor of biochemical freedom from disease (bNED) and describ ... Full text Link to item Cite

Systematic biopsies: do they add prognostic information in men with clinically localized prostate cancer treated with radiation therapy alone?

Journal Article Radiology · February 1996 PURPOSE: To determine whether systematic biopsy can help predict treatment outcome in men with clinically localized prostate cancer treated with external-beam radiation therapy alone. MATERIALS AND METHODS: Two hundred twenty-four men with clinically local ... Full text Link to item Cite

Oropharyngeal carcinoma treated with radiotherapy: a 30-year experience.

Journal Article Int J Radiat Oncol Biol Phys · January 15, 1996 PURPOSE: This study was done to determine the outcome in patients with oropharyngeal carcinoma treated at the University of Florida with radiotherapy alone to the primary site, for comparison with reported results of other types of treatment. METHODS AND M ... Full text Link to item Cite

Pretreatment serum prostate-specific antigen (PSA) level and PSA doubling times (PSADT) in black and white men with prostate cancer referred for radiation therapy

Journal Article Radiation Oncology Investigations · 1996 Numerous racial differences have been reported for carcinoma of the prostate diagnosed in African-American (AA) men when compared to whites. These differences include: (1) a higher incidence in AA compared to whites, (2) a more advanced stage at diagnosis ... Full text Cite

Abnormal extracellular material in the levator palpebrae superioris complex in congenital ptosis.

Journal Article Arch Ophthalmol · November 1995 OBJECTIVE: To determine the pathologic abnormalities of the levator palpebrae superioris in congenital ptosis. METHODS: By means of light and electron microscopy and immunohistochemistry, anterior levator tissue specimen from 15 patients with congenital pt ... Full text Link to item Cite

Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells.

Journal Article Mutat Res · October 1995 The 2-chloroethyl methanesulfonate (2ClEMS)-induced alcohol dehydrogenase (Adh) null germline mutation frequency in treated Drosophila melanogaster second instar larval gonia was two orders of magnitude greater than the spontaneous mutation frequency. DNA ... Full text Link to item Cite

Pretreatment hemoglobin level influences local control and survival of T1-T2 squamous cell carcinomas of the glottic larynx.

Journal Article J Clin Oncol · August 1995 PURPOSE: A number of reports have documented the relationship between pretreatment hemoglobin level and local control and/or survival in the treatment of cervix, bladder, and advanced head and neck tumors. Consideration of correcting anemia before initiati ... Full text Link to item Cite

Clinical and biochemical evidence of control of prostate cancer at 5 years after external beam radiation.

Journal Article The Journal of urology · August 1995 PURPOSE: We demonstrate the 5-year survival rate for patients with prostate cancer treated by irradiation, the value of the conformal technique and prostate specific antigen (PSA) doubling times after irradiation. MATERIALS AND METHODS: The outcome of 502 ... Cite

Clinical and biochemical evidence of control of prostate cancer at 5 years after external beam radiation.

Journal Article J Urol · August 1995 PURPOSE: We demonstrate the 5-year survival rate for patients with prostate cancer treated by irradiation, the value of the conformal technique and prostate specific antigen (PSA) doubling times after irradiation. MATERIALS AND METHODS: The outcome of 502 ... Full text Link to item Cite

Management of extremity soft tissue sarcomas with limb-sparing surgery and postoperative irradiation: do total dose, overall treatment time, and the surgery-radiotherapy interval impact on local control?

Journal Article Int J Radiat Oncol Biol Phys · July 15, 1995 PURPOSE: To evaluate potential prognostic factors in the treatment of extremity soft tissue sarcomas that may influence local control, distant metastases, and overall survival. METHODS AND MATERIALS: Sixty-seven patients with extremity soft tissue sarcomas ... Full text Link to item Cite

Incidence of and factors related to late complications in conformal and conventional radiation treatment of cancer of the prostate.

Journal Article Int J Radiat Oncol Biol Phys · June 15, 1995 PURPOSE: The fundament hypothesis of conformal radiation therapy is that tumor control can be increased by using conformal treatment techniques that allow a higher tumor dose while maintaining an acceptable level of complications. To test this hypothesis, ... Full text Link to item Cite

Prostate specific antigen density is not an independent predictor of response for prostate cancer treated by conformal radiotherapy.

Journal Article J Urol · June 1995 Although prostate specific antigen (PSA) density appears to be an important discriminator between benign and malignant prostatic disease, conflicting data exist concerning its prognostic value. The present study was undertaken to confirm whether PSA densit ... Link to item Cite

Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase.

Journal Article Biochem J · June 1, 1995 We have determined the nucleotide sequences of eight ethyl methanesulphonate-induced mutants in Drosophila alcohol dehydrogenase (ADH), of which six were previously characterized by Hollocher and Place [(1988) Genetics 116, 253-263 and 265-274]. Four of th ... Full text Link to item Cite

Conformal treatment of prostate cancer with improved targeting: superior prostate-specific antigen response compared to standard treatment.

Journal Article Int J Radiat Oncol Biol Phys · May 15, 1995 PURPOSE: Conformal radiation therapy (CRT) decreases the morbidity of prostate cancer treatment, but no published data attest to the improved ability of CRT to control disease. Therefore, we compared Prostate-Specific Antigen (PSA) response at 1 year among ... Full text Link to item Cite

Do the current subclassifications of stage T3 adenocarcinoma of the prostate have clinical relevance?

Journal Article Urology · March 1995 OBJECTIVES: To compare the outcome of patients with T3a and T3c adenocarcinoma of the prostate and determine the utility of these substages as defined in the current American Joint Committee on Cancer and the International Union Against Cancer (AJCC/UICC) ... Full text Link to item Cite

Ultrastructural study of the corneal epithelium in the recurrent erosion syndrome.

Journal Article Br J Ophthalmol · March 1995 BACKGROUND: This study describes the adhesion systems in the corneal epithelium in the recurrent erosion syndrome and the mechanisms by which binucleate and multinucleate cells are formed within the epithelium. METHODS: Twenty five samples of sliding epith ... Full text Link to item Cite

One step forward and two steps back.

Journal Article Int J Radiat Oncol Biol Phys · February 15, 1995 Link to item Cite

Localized prostate cancer treated by external-beam radiotherapy alone: serum prostate-specific antigen--driven outcome analysis.

Journal Article J Clin Oncol · February 1995 PURPOSE: To determine the 5-year rate of survival with no evidence of disease (NED) using strict biochemical criteria in men with prostate cancer treated by external-beam radiotherapy alone and to examine possible clinical and treatment factors that predic ... Full text Link to item Cite

Hydrogen peroxide induces microvilli on human retinal pigment epithelial cells in culture.

Journal Article Cell Biol Int · February 1995 We have found that hydrogen peroxide (10(-4)-10(-2) M) rapidly induces microvilli on separate cells and confluent sheets of human retinal pigment epithelium in culture. t-butyl hydroperoxide and sodium arsenite do not induce microvilli. A role for hydrogen ... Full text Link to item Cite

Radiation therapy following radical prostatectomy

Journal Article Cancer · January 1, 1995 Background. The incidence of pathologic upstaging to stage T3 is a common occurrence in patients undergoing radical prostatectomy for clinical stage T1‐2 prostate cancer. There is a considerable risk of local recurrence owing radical prostatectomy for path ... Full text Cite

External beam irradiation of prostate cancer. Conformal treatment techniques and outcomes for the 1990

Journal Article Cancer · January 1, 1995 Background. This paper presents the results of external beam treatment of prostate cancer. Long term results are represented by the U.S. national averages from the Patterns of Care study. The modern innovations of three‐dimensional‐assisted conformal treat ... Full text Cite

Observations of pretreatment prostate-specific antigen doubling time in 107 patients referred for definitive radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 1995 PURPOSE: To determine pretreatment prostate-specific antigen doubling times (PSADT) in patients referred for definitive radiotherapy. METHODS AND MATERIALS: One hundred and seven patients with histologically proven nonmetastatic prostate cancer and an elev ... Full text Link to item Cite

Histopathology of macular holes.

Journal Article Ophthalmology · January 1995 Full text Link to item Cite

Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among drosophila, mouse, and human.

Journal Article Environ Mol Mutagen · 1995 Spontaneous mutation rates per generation are similar among the three species considered here--Drosophila, mouse, and human--and are not related to time, as is often assumed. Spontaneous germline mutation rates per generation averaged among loci are less v ... Full text Link to item Cite

20th annual Frank Costenbader Lecture--adult strabismus.

Journal Article J Pediatr Ophthalmol Strabismus · 1995 BACKGROUND: A retrospective analysis of adults with strabismus was done to examine the potential risks and the possible benefits of surgical treatment and to describe the types of adult strabismus. METHODS: Eight hundred ninety-two patients were analyzed. ... Full text Link to item Cite

Uveal melanoma: updated considerations on current management modalities.

Journal Article Int Ophthalmol · 1995 Published data on growth rates of uveal melanomas and effects of treatment modalities raise important considerations. Dissemination from uveal melanomas starts after the tumour is larger than 7 mm diameter; growth from 7 to 10 mm diameter increases the ris ... Full text Link to item Cite

External beam irradiation of prostate cancer: Conformal treatment techniques and outcomes for the 1990s

Journal Article Cancer · 1995 Background. This paper presents the results of external beam treatment of prostate cancer. Long term results are represented by the U.S. national averages from the Patterns of Care study. The modern innovations of three- dimensional-assisted conformal trea ... Cite

Radiation therapy following radical prostatectomy

Journal Article Cancer · 1995 Background. The incidence of pathologic upstaging to stage T3 is a common occurrence in patients undergoing radical prostatectomy for clinical stage T1-2 prostate cancer. There is a considerable risk of local recurrence following radical prostatectomy for ... Cite

Adding a positive charge at residue 46 of Drosophila alcohol dehydrogenase increases cofactor specificity for NADP+.

Journal Article FEBS Lett · December 12, 1994 We previously reported that the D39N mutant of Drosophila alcohol dehydrogenase (ADH), in which Asp-39 is replaced with asparagine, has a 60-fold increase in affinity for NADP+ and a 1.5-fold increase in kcat compared to wild-type ADH [Chen et al. (1991) E ... Full text Link to item Cite

Multirecurrence of corneal posterior polymorphous dystrophy. An ultrastructural study.

Journal Article Cornea · November 1994 Posterior polymorphous corneal dystrophy (PPD) is a rare bilateral, autosomal-dominant disease. The presence of the epitheliumlike endothelium and the thickening of Descemet's membrane by the posterior collagenous layer (PCL) has been reported in the major ... Link to item Cite

Immunogold study of non-collagenous matrix components in normal and exfoliative iris.

Journal Article Br J Ophthalmol · November 1994 The present investigation was undertaken to determine if some of the components of exfoliation material in iris tissue were unique to exfoliation or were part of normal iris architecture. Eleven normal iris specimens and 10 exfoliative iris specimens were ... Full text Link to item Cite

Early prostate cancer: the national results of radiation treatment from the Patterns of Care and Radiation Therapy Oncology Group studies with prospects for improvement with conformal radiation and adjuvant androgen deprivation.

Journal Article J Urol · November 1994 Long-term outcome of the Patterns of Care Study and the Radiation Therapy Oncology Group are used to demonstrate the national average results of treating early prostate cancer in the United States. A group of patients with stage T1B2 disease and pathologic ... Full text Link to item Cite

Radiologic appearance of the irradiated larynx. Part I. Expected changes.

Journal Article Radiology · October 1994 PURPOSE: To present the expected appearance of the irradiated larynx and neck as seen at computed tomography (CT). MATERIALS AND METHODS: Sixty-one patients with primary squamous cell carcinoma of the larynx or hypopharynx were treated with radiation thera ... Full text Link to item Cite

Radiologic appearance of the irradiated larynx. Part II. Primary site response.

Journal Article Radiology · October 1994 PURPOSE: To evaluate the computed tomographic (CT) appearance of laryngeal tumors treated with radiation therapy and the ability of CT to depict persistent or residual tumor. MATERIALS AND METHODS: Sixty-one patients with primary squamous cell carcinoma of ... Full text Link to item Cite

Bacillary angiomatosis of the conjunctiva.

Journal Article Am J Ophthalmol · August 15, 1994 A 70-year-old man had unilateral congestion of the right upper eyelid, which contained a nodular mass. A biopsy was performed, and histologic, immunocytochemical, and ultrastructural studies disclosed a pseudoneoplastic proliferation of endothelial cells a ... Full text Link to item Cite

Value of laryngeal cartilage sclerosis as a predictor of outcome in patients with stage T3 glottic cancer treated with radiation therapy.

Journal Article Radiology · August 1994 PURPOSE: To determine whether sclerosis of the laryngeal cartilages was a predictor of a poor outcome in patients with stage T3 glottic cancer treated with radiation therapy. MATERIALS AND METHODS: Thirty-three patients with stage T3 glottic cancer underwe ... Full text Link to item Cite

Bilateral uveal melanoma presenting simultaneously.

Journal Article Ger J Ophthalmol · August 1994 A case of bilateral uveal melanoma in a 54-year-old man is described. On admission of the patient for a choroidal melanoma of the left eye, an asymptomatic ciliary-body tumour was detected in his right eye. A thorough general examination did not reveal any ... Link to item Cite

Corneal endothelial cell abnormalities in an early stage of the iridocorneal endothelial syndrome.

Journal Article Br J Ophthalmol · August 1994 A corneal disc, obtained from a 52-year-old woman suffering from an early stage of the iridocorneal endothelial syndrome (ICE), was investigated by various morphological techniques to analyse the structural variations in the endothelial cells and to identi ... Full text Link to item Cite

An ultrastructural investigation of an early manifestation of the posterior polymorphous dystrophy of the cornea.

Journal Article Ophthalmology · August 1994 BACKGROUND: Posterior polymorphous dystrophy of the cornea is an uncommon, but well-recognized, congenital disease affecting Descemet's membrane and endothelium. Visual impairment usually is minimal and slowly progressive. Edema develops in a small number ... Full text Link to item Cite

Radiotherapy alone for carcinoma of the vagina: the importance of overall treatment time.

Journal Article Int J Radiat Oncol Biol Phys · July 30, 1994 PURPOSE: Review treatment results, complications, and the importance of overall treatment time for carcinoma of the vagina treated with radiotherapy alone. METHODS AND MATERIALS: Between October 1964 and October 1990, 65 patients with histologically confir ... Full text Link to item Cite

Immuno-electron labelling of matrix components in congenital hereditary endothelial dystrophy.

Journal Article Graefes Arch Clin Exp Ophthalmol · June 1994 Two corneal buttons were obtained from a patient with congenital hereditary endothelial dystrophy (CHED) at the ages of 2.5 years (right eye) and 14 years (left eye) and were studied by light and electron microscopy including immunogold labelling for colla ... Full text Link to item Cite

The influence of large deletions on the mutation frequency induced by tritiated water and X-radiation in male Drosophila melanogaster post-meiotic germ cells.

Journal Article Mutat Res · May 1, 1994 Tritium beta radiation (3H beta-radiation) in the form of tritiated water was used to induce mutations at the alcohol dehydrogenase (Adh) locus in male Drosophila melanogaster post-meiotic germ cells. All 23 Adh null mutations were large deletions (> 20 kb ... Full text Link to item Cite

Collagens in the aged human macula.

Journal Article Graefes Arch Clin Exp Ophthalmol · March 1994 Immunogold cytochemistry was used to investigate the fine structural distribution of collagen types I-VI in Bruch's membrane and choroid of the aged human macula. Macular tissue was obtained from ten eyes, and processed for cryoultramicrotomy and London Re ... Full text Link to item Cite

T2‐T3 carcinoma of the supraglottic larynx: A comparison of surgery and radiotherapy

Journal Article Radiation Oncology Investigations · January 1, 1994 This paper compares results for T2‐T3 carcinoma of the supraglottic larynx treated with radiotherapy (RT), supraglottic laryngectomy, or total laryngectomy. Two hundred thirty patients with T2‐T3 carcinoma of the supraglottic larynx were treated at the Uni ... Full text Cite

Prostate cancer.

Journal Article Current problems in cancer · 1994 Prostate cancer is the most common noncutaneous malignancy diagnosed in American men, and in 1994 it will pass lung cancer as the most common cancer diagnosed in the United States, with an estimated 200,000 new cases. The molecular biology of prostate carc ... Cite

Pathology of hereditary retinal degeneration associated with hypobetalipoproteinemia.

Journal Article Ophthalmology · January 1994 BACKGROUND: The clinical features and previously unreported ocular pathology in a case of heterozygous hypobetalipoproteinemia (HBL) associated with a pigment epitheliopathy are documented. Night blindness developed in a white woman with familial heterozyg ... Full text Link to item Cite

Congenital ocular defects associated with an abnormality of the human chromosome 1: trisomy 1q32-qter.

Journal Article J Pediatr Ophthalmol Strabismus · 1994 This article describes the detailed ocular pathology found in a premature neonate, born at 34 weeks, with multiple congenital anomalies resulting from de novo trisomy 1q32-qter. The ocular defects include goniodysgenesis, persistent tunica vasculosa lentis ... Full text Link to item Cite

Prostate cancer.

Journal Article Curr Probl Cancer · 1994 Prostate cancer is the most common noncutaneous malignancy diagnosed in American men, and in 1994 it will pass lung cancer as the most common cancer diagnosed in the United States, with an estimated 200,000 new cases. The molecular biology of prostate carc ... Full text Link to item Cite

Localized carcinoma of the prostate (stages T1B, T1C, T2, and T3). Review of management with external beam radiation therapy.

Journal Article Cancer · December 1, 1993 BACKGROUND: Optimal treatment for patients with localized carcinoma of the prostate is controversial. Radiation therapy is an established modality in the management of these patients, and several reports indicate the results are comparable to those achieve ... Full text Link to item Cite

Morphology of iris vasculopathy in exfoliation glaucoma.

Journal Article Acta Ophthalmol (Copenh) · December 1993 Iris tissue obtained from 26 consecutive patients operated upon for exfoliation glaucoma and control iris tissue from 26 age-matched subjects operated upon for primary open angle glaucoma was used to investigate the iris vasculopathy associated with exfoli ... Full text Link to item Cite

Morphometric assessment of the central retinal artery and vein in the optic nerve head.

Journal Article Can J Ophthalmol · December 1993 The exact anatomy of the central retinal vein as it exits the eye is unknown. In this study serial sections of the central retinal vein and artery in the anterior optic nerve from six globes (five from cornea donors and one exenteration specimen) were exam ... Link to item Cite

Elective inguinal lymph node irradiation for pelvic carcinomas. The University of Florida experience.

Journal Article Cancer · September 15, 1993 BACKGROUND: There is little published information pertaining to elective inguinal lymph node irradiation for carcinomas originating in the pelvis that place the inguinal lymph nodes at risk. METHODS: Between October 1964 and October 1988, 164 patients with ... Link to item Cite

Collagens in ocular tissues.

Journal Article Br J Ophthalmol · August 1993 Full text Link to item Cite

Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure.

Journal Article J Biol Chem · July 25, 1993 On the basis of its primary sequence and the location of its disulfide bonds, we propose a structural model of the erythropoietic hormone erythropoietin (Epo) which predicts a four alpha-helical bundle motif, in common with other cytokines. In order to tes ... Link to item Cite

Mutational analysis of the leucine zipper-like motif of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein.

Journal Article J Virol · June 1993 The N-terminal region of the envelope (env) transmembrane protein of human immunodeficiency virus type 1 (HIV-1) has a leucine zipper-like motif. This highly conserved zipper motif, which consists of a heptad repeat of leucine or isoleucine residues, has b ... Full text Link to item Cite

Prevalence, diagnostic features, and response to trabeculectomy in exfoliation glaucoma.

Journal Article Ophthalmology · May 1993 BACKGROUND: The "true" prevalence and clinical attributes of exfoliation glaucoma remain controversial. The authors studied these characteristics in glaucoma patients requiring trabeculectomy. METHODS: One hundred consecutive patients undergoing trabeculec ... Full text Link to item Cite

Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis.

Journal Article Biochemistry · April 6, 1993 Amino acid sequence comparisons reveal that tyrosine-152 and lysine-156 of Drosophila alcohol dehydrogenase (ADH) are conserved in homologous dehydrogenases, suggesting that these residues are important in catalysis. To test this hypothesis, we used site-d ... Full text Link to item Cite

Can pretreatment computed tomography findings predict local control in T3 squamous cell carcinoma of the glottic larynx treated with radiotherapy alone?

Journal Article Int J Radiat Oncol Biol Phys · March 15, 1993 PURPOSE: To determine if pretreatment computed tomography findings can predict local control in T3 squamous cell carcinoma of the glottic larynx treated with radiotherapy alone. METHODS AND MATERIALS: Twenty-nine patients with previously untreated T3 squam ... Full text Link to item Cite

Collagens in the aged human macular sclera.

Journal Article Curr Eye Res · February 1993 Scleral tissue from the region of the human macula was studied by the immunogold labeling technique (cryoultramicrotomy and LR white resin embedding) in an attempt to identify the fine structural distribution of collagen types I-VI. Labeling of the striate ... Full text Link to item Cite

Uveitis and retinal vasculitis in acute experimental allergic encephalomyelitis in the Lewis rat: an ultrastructural study.

Journal Article Exp Eye Res · February 1993 The histopathological features of uveitis and retinal vasculitis in acute experimental allergic encephalomyelitis (EAE) were investigated using light and electron microscopy. Lewis rats were immunized by spinal cord homogenate, complete Freund's adjuvant a ... Full text Link to item Cite

Carcinoma of the tonsillar region: a multivariate analysis of 243 patients treated with radical radiotherapy.

Journal Article Head Neck · 1993 Between October 1964 and June 1990, 243 patients with squamous cell carcinoma of the tonsillar region were treated with continuous-course radical radiotherapy at the University of Florida. All patients had a minimum 2-year follow-up. Patients were staged a ... Full text Link to item Cite

Radical radiotherapy for T4 carcinoma of the skin of the head and neck: a multivariate analysis.

Journal Article Head Neck · 1993 Sixty-seven patients with 68 stage T4 carcinomas of the skin of the head and neck were treated with radical radiotherapy at the University of Florida between October 1964 and November 1989. Thirty-three lesions were previously untreated and 35 were recurre ... Full text Link to item Cite

Bilateral Kimura's disease of the eyelids.

Journal Article Br J Ophthalmol · December 1992 A case of Kimura's disease affecting the eyelids bilaterally is reported in a 5-year-old boy of Afro-Caribbean extraction who has been followed for 12 years with repeat biopsies. He initially presented at 5 years of age with swelling of the left upper eyel ... Full text Link to item Cite

Variations in the ganglioside profile of uveal melanoma correlate with cytologic heterogeneity.

Journal Article Int J Cancer · November 11, 1992 Gangliosides may play an important role in the proliferation and spread of human malignant melanoma. Because the frequency of metastases in uveal and cutaneous melanoma differs, it is possible that they may express different gangliosides. We analyzed the g ... Full text Link to item Cite

Cigarette smoking and small irregular opacities.

Journal Article Br J Ind Med · November 1992 Full text Link to item Cite

Type IV collagen and laminin in Bruch's membrane and basal linear deposit in the human macula.

Journal Article Br J Ophthalmol · October 1992 Tissue obtained from the macula in 10 human eyes (53-77 years) was used for an investigation into the extracellular matrices of the retinal pigment epithelium (RPE), Bruch's membrane, and the choriocapillaris. The ultrastructural distribution of type IV co ... Full text Link to item Cite

Extracellular matrix in aged human ciliary body: an immunoelectron microscope study.

Journal Article Invest Ophthalmol Vis Sci · July 1992 Tissue from nine human eyes (ages 52-78 yr) was used to investigate the fine structural distribution of collagens I-VI and laminin in the ciliary body using the immunogold antibody labeling technique. The anterior segments of the specimens were normal, and ... Link to item Cite

"Clawbacks".

Journal Article Br J Ind Med · July 1992 Full text Link to item Cite

Nonrandom distribution of gp120 N-linked glycosylation sites important for infectivity of human immunodeficiency virus type 1.

Journal Article Proc Natl Acad Sci U S A · March 15, 1992 More than 20 consensus N-linked glycosylation sites occur in the gp120 coding sequence of most isolates of human immunodeficiency virus type 1. Based on the N-linked glycosylation pattern of a well-characterized recombinant gp120, it is likely that N-linke ... Full text Link to item Cite

A scanning electron microscope study of porcine corneal endothelium stored in chondroitin sulphate.

Journal Article Cornea · March 1992 The porcine cornea was used as a model for the study of the effects of corneal storage in 2.5% chondroitin sulphate at 3, 5, 8, and 10 days. The corneal endothelium was studied by scanning electron microscopy and image analysis was used to measure cell are ... Full text Link to item Cite

Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41.

Journal Article J Virol · March 1992 Amino acid substitutions were introduced into four conserved N-linked glycosylation sites of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein, gp41, to alter the canonical N-linked glycosylation sequences. One altered site produc ... Full text Link to item Cite

An immunoelectron microscope study of the aged human lens capsule.

Journal Article Exp Eye Res · March 1992 The distribution of types I-IV collagen and laminin was studied in seven aged human lens capsules using the immunogold EM technique on LR White embedded tissue. Samples were taken from the anterior, equatorial and posterior regions. Labelling for type II c ... Full text Link to item Cite

Mechanisms for dominance: Adh heterodimer formation in heterozygotes between ENU or X-ray induced null alleles and normal alleles in Drosophila melanogaster.

Journal Article Environ Mol Mutagen · 1992 To study mechanisms for dominance of phenotype, eight ENU- and four X-ray-induced mutations at the alcohol dehydrogenase (Adh) locus were analyzed for partial dominance in their interaction with normal alleles. All ENU and one of the X-ray mutations were s ... Full text Link to item Cite

A case of developmental glaucoma presenting with abdominal colic and subnormal intraocular pressure.

Journal Article J Pediatr Ophthalmol Strabismus · 1992 A healthy baby boy presented with abdominal colic. He was subsequently noted to have enlarged, edematous corneas. A clinical diagnosis of developmental glaucoma was made despite ocular hypotony. Trabeculectomies were designed to include peripheral cornea. ... Full text Link to item Cite

Role of aspartic acid 38 in the cofactor specificity of Drosophila alcohol dehydrogenase.

Journal Article Eur J Biochem · December 5, 1991 Drosophila alcohol dehydrogenase (ADH), an NAD(+)-dependent dehydrogenase, shares little sequence similarity with horse liver ADH. However, these two enzymes do have substantial similarity in their secondary structure at the NAD(+)-binding domain [Benyajat ... Full text Link to item Cite

Short term prospective study of cognitive functioning in lead workers.

Journal Article Br J Ind Med · November 1991 In a short term prospective study 70 male lead workers performed a series of cognitive tasks on three occasions during an eight month period. Concurrently with the cognitive testing, the concentrations of blood lead, zinc protoporphyrin (ZPP) and urinary a ... Full text Link to item Cite

Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity.

Journal Article J Virol · November 1991 All animal retroviruses whose nucleotide sequences have been determined contain two or three closely spaced cysteine residues in the extracellular domain of the env-encoded transmembrane protein. Using human immunodeficiency virus type 1 gp41 as a working ... Full text Link to item Cite

The 40-kilodalton allergen of Candida albicans is an alcohol dehydrogenase: molecular cloning and immunological analysis using monoclonal antibodies.

Journal Article Clin Exp Allergy · November 1991 To characterize the 40-kilodalton (kD) major allergen of Candida albicans (C. albicans), six monoclonal antibodies (MoAbs) against this allergen were generated. In SDS-polyacrylamide gel electrophoresis and immunoblot analysis, these MoAbs showed four diff ... Full text Link to item Cite

Iris vasculopathy in exfoliation syndrome. An immunocytochemical study.

Journal Article Acta Ophthalmol (Copenh) · August 1991 Samples of control iris tissue obtained from seven enucleated eyes and nine exfoliative iridectomy specimens were prepared for an immunocytochemical study of the matrix in the walls of iris vessels. The distribution of collagen types I, IV and laminin was ... Full text Link to item Cite

Lead astray?

Journal Article Br J Ind Med · June 1991 Full text Link to item Cite

Immunogold ultrastructural localization of collagens in the aged human outflow system.

Journal Article Ophthalmology · May 1991 Immunogold labeling was applied at the ultrastructural level to the identification of collagen types I, II, III, V, and VI in the human trabecular meshwork obtained from 11 surgically enucleated globes. Both London resin white embedding and cryoultramicrot ... Full text Link to item Cite

Post-traumatic hyperlipofuscinosis in the human retinal pigment epithelium.

Journal Article Br J Ophthalmol · January 1991 Light microscopy (including fluorescence microscopy) and electron microscopy were applied to a study of the photoreceptor-retinal pigment epithelium (RPE) complex in a human eye which had been severely traumatised nine months prior to enucleation. The main ... Full text Link to item Cite

Immunogold fine structural localization of extracellular matrix components in aged human cornea. II. Collagen types V and VI.

Journal Article Graefes Arch Clin Exp Ophthalmol · 1991 Using immunogold immunocytochemical techniques we studied the distribution of collagen types V and VI in corneal tissue from seven enucleated human eyes (age range, 63-78 years). Results obtained by cryoultramicrotomy were marginally more intense than thos ... Full text Link to item Cite

Immunogold fine structural localization of extracellular matrix components in aged human cornea. I. Types I-IV collagen and laminin.

Journal Article Graefes Arch Clin Exp Ophthalmol · 1991 Using the immunogold technique combined with cryoultramicrotomy and London Resin white (LR white) embedding, we studied the fine structural distribution of types I-IV collagen and laminin in corneal tissue from seven enucleated human eyes (age range, 63-78 ... Full text Link to item Cite

Laryngeal and ocular granulation tissue formation in two Punjabi children: LOGIC syndrome.

Journal Article Eye (Lond) · 1991 Two unrelated children, both born in the United Kingdom of Punjabi Muslim parents, developed within months of birth, nodules in the larynx, conjunctiva and nailbeds. Currently the younger female child, aged five, is developing skin papules while the elder ... Full text Link to item Cite

DNA sequence analysis of X-ray induced Adh null mutations in Drosophila melanogaster.

Journal Article Environ Mol Mutagen · 1991 The mutational spectrum for 28 X-ray induced mutations and 2 spontaneous mutations, previously determined by genetic and cytogenetic methods, consisted of 20 multilocus deficiencies (19 induced and 1 spontaneous) and 10 intragenic mutations (9 induced and ... Full text Link to item Cite

Dedifferentiation potential of iris melanomas.

Journal Article Fortschr Ophthalmol · 1991 A histopathological study was conducted on four cases in which a diffuse iris melanoma presented with glaucoma. Drainage surgery was performed on three eyes for medically non-responsive raised intraocular pressure, and all cases eventually (within 2-7 year ... Link to item Cite

Immunogold localization of type IV collagen and laminin in the aging human outflow system.

Journal Article Exp Eye Res · December 1990 Tissue from the outflow system of six surgically enucleated aged eyes was used for an ultrastructural immunocytochemical study of the distribution of laminin and type IV collagen. The immunogold technique provided precise localization of laminin beneath li ... Full text Link to item Cite

Multifocal posterior uveitis: clinical and pathological findings.

Journal Article Br J Ophthalmol · November 1990 A pathological study was performed on the necropsy eyes of a 59-year old-woman who had suffered for nine years from multifocal posterior uveitis. The disease had been controlled by steroid therapy with good preservation of visual function. Extensive invest ... Full text Link to item Cite

Analysis of lymphocytic infiltration in uveal melanoma.

Journal Article Invest Ophthalmol Vis Sci · October 1990 Among 27 uveal melanomas, five were found to contain tumor infiltrating lymphocytes (TILs). Four had high levels of lymphocytes, and the fifth had comparatively low levels but adequate numbers for comprehensive analysis. The TILs were analyzed by flow cyto ... Link to item Cite

Low level exposure to lead.

Journal Article BMJ · September 15, 1990 Full text Link to item Cite

Immunogold localisation of laminin in normal and exfoliative iris.

Journal Article Br J Ophthalmol · August 1990 Immunoelectron microscopic studies of exfoliative iris tissue (seven specimens) revealed the presence of laminin in the fibrillar component of exfoliation material. The immunogold label was uniformly distributed on the exfoliation fibres. Deposition of lam ... Full text Link to item Cite

Analysis of ENU-induced mutations at the Adh locus in Drosophila melanogaster.

Journal Article Mutat Res · July 1990 N-Ethyl-N-nitrosourea (ENU) was used to induce mutations in the Drosophila melanogaster, alcohol dehydrogenase (Adh) gene. Flies were treated with ENU and mated to homozygous intragenic Adh null mutants; Adh null mutations were selected by exposure of the ... Full text Link to item Cite

Comparison of dose-response relationships for ethyl methanesulfonate and 1-ethyl-1-nitrosourea in Drosophila melanogaster spermatozoa.

Journal Article Mutat Res · July 1990 The relative importance of different sites of alkylation on DNA was determined by comparing two ethylating agents. 1-Ethyl-1-nitrosourea (ENU) ethylates DNA with a higher proportion of total adducts on ring oxygens than ethyl methanesulfonate, which ethyla ... Full text Link to item Cite

The importance of molecular dosimetry and analysis of mutations for estimation of genetic risk.

Journal Article Mutat Res · July 1990 A method of estimating risk to germ cells is developed by using both molecular dosimetry and analysis of mutations for points of commonality in comparison among test systems. Studies on adduct formation can be related to dose in germ cells of test systems ... Full text Link to item Cite

Experimental autoimmune uveoretinitis and pinealitis induced by interphotoreceptor retinoid-binding protein and S-antigen: induction of intraretinal and subretinal neovascularization.

Journal Article J Clin Lab Immunol · May 1990 Experimental autoimmune uveoretinitis (EAU) and pinealitis were induced in Lewis rats following hind foot pad injection of interphotoreceptor retinoid-binding protein (IRBP) or S-antigen. A comparison is made in this study of the in vivo and histological c ... Link to item Cite

Ultrastructural distribution of collagen types I-VI in aging human retinal vessels.

Journal Article Br J Ophthalmol · April 1990 Retinal vessels from freshly enucleated human eyes were classified into three stages of the hyalinisation process. The distribution of collagen types I-VI within the vessel walls was studied ultrastructurally by immunogold labelling combined with the tissu ... Full text Link to item Cite

Effects of age and rapid high-pressure fixation on the morphology of Schlemm's canal.

Journal Article Invest Ophthalmol Vis Sci · April 1990 An analysis of size, shape, vacuole and cell counts of Schlemm's canal was undertaken in 20 human eyes that had undergone conventional immersion fixation. A reduction in vacuole count with age was shown to be associated with a decreased canal cell count. T ... Link to item Cite

Bovine retinal explants cultured in collagen gels. A model system for the study of proliferative retinopathy.

Journal Article Arch Ophthalmol · March 1990 We have developed a model system for studying proliferative retinopathy in vitro using bovine retinal explants cultured in collagen gels. Cellular outgrowth from retinal explants occurred after 7 days as single cells from peripapillary explants or as cell ... Full text Link to item Cite

Site-directed mutagenesis of glycine-14 and two "critical" cysteinyl residues in Drosophila alcohol dehydrogenase.

Journal Article Biochemistry · February 6, 1990 Three amino acid residues (glycine-14, cysteine-135, and cysteine-218) previously speculated to be important for the structure and function of Drosophila melanogaster alcohol dehydrogenase have been investigated by using site-directed mutagenesis followed ... Full text Link to item Cite

Immunocytochemical localisation of collagens (I?V) in the human iris

Journal Article Graefe's Archive for Clinical and Experimental Ophthalmology · 1990 Full text Cite

Immunocytochemical localisation of collagens (I-V) in the human iris.

Journal Article Graefes Arch Clin Exp Ophthalmol · 1990 In this study we investigated the distribution of collagen types I-V in the human iris at the fine-structural level using cryoultramicrotomy and London Resin White plastic embedding. Collagen type I was shown to be present in the basement membrane of iris ... Full text Link to item Cite

Ultrastructural pleomorphism in medulloepithelioma of the ciliary body: a comparative study of tumour cells and fetal ciliary epithelium.

Journal Article Jpn J Ophthalmol · 1990 A locally aggressive nonteratoid intraocular medulloepithelioma occurring in a two-year-old boy was studied by electron microscopy. For comparison the primitive pars plana region was examined in human fetal eyes obtained at 16, 18 and 22 weeks of gestation ... Link to item Cite

Posterior axial corneal malformation and uveoretinal angiodysgenesis--a neurocristopathy?

Journal Article Graefes Arch Clin Exp Ophthalmol · 1990 This clinicopathological report describes an unusual combination of axial corneal malformation and angiodysgenesis in the uvea, retina and optic nerve in three eyes. In each specimen there was hypocellularity in the posterior axial stroma, with correspondi ... Full text Link to item Cite

The uveal effusion syndrome and trans-scleral flow.

Journal Article Eye (Lond) · 1990 Recent studies of the uveal effusion syndrome, a rare condition characterised by idiopathic spontaneous serous detachment of the retina and peripheral choroid, have suggested a primary scleral abnormality as the underlying cause. In particular, abnormal de ... Full text Link to item Cite

Cognitive functioning in lead workers.

Journal Article Br J Ind Med · October 1989 In a cross sectional study of occupational exposure to inorganic lead 91 men performed a series of microcomputer based tasks assessing sensor motor reaction time, memory, attention, verbal reasoning, and spatial processing. Performance on the tasks was stu ... Full text Link to item Cite

Dosage-response relationships for methyl methanesulfonate in Drosophila melanogaster spermatozoa: DNA methylation per nucleotide vs. sex-linked recessive lethal frequency.

Journal Article Mutat Res · April 1989 Two different mechanisms for mutagenesis following treatment with methyl methanesulfonate (MMS) are suggested from the dose-response curve that is best fit by the linear quadratic model where m = 0.130D + 0.038D2 (D = dose measured as alkylations per nucle ... Full text Link to item Cite

Relative biological effectiveness of tritiated water to gamma radiation for germ line mutations.

Journal Article Radiat Res · March 1989 The relative biological effectiveness was determined using sex-linked recessive lethals induced in Drosophila spermatozoa as the biological effect. The sex-linked recessive lethal test, a measure of mutations induced in germ cells and transmitted through s ... Link to item Cite

Training for occupational medicine.

Journal Article Postgrad Med J · March 1989 Full text Link to item Cite

Ocular blood flow in unilateral carotid stenosis and hypotension.

Journal Article Invest Ophthalmol Vis Sci · March 1989 Ocular blood flow was measured in the juxtapapillary choroid, retrolaminar optic nerve and ciliary body mesoderm using 14C-labelled iodoantipyrine with quantitative autoradiography in seven anesthetized baboons in an experimental model of cerebral and ocul ... Link to item Cite

Addition of molecular methods to mutation studies with Drosophila melanogaster.

Journal Article Environ Mol Mutagen · 1989 For 80 years, Drosophila melanogaster has been used as a major tool in analyzing Mendelian genetics. By using chromosome inversions that suppress crossing over, geneticists have developed a large number of stocks for mutation analysis. These stocks permit ... Full text Link to item Cite

Detection and quantification of S-100 protein in ocular tissues and fluids from patients with intraocular melanoma.

Journal Article Br J Ophthalmol · November 1988 S-100 protein is a 21,000 dalton acidic calcium-binding protein present in ocular melanomas and some normal ocular tissues. Ocular fluids and extracts of ocular tumours were examined by a sensitive radioimmunoassay that could detect less than 5 ng of S-100 ... Full text Link to item Cite

Short-pulsed neodymium-YAG laser trabeculotomy. An in vivo morphological study in the human eye.

Journal Article Invest Ophthalmol Vis Sci · November 1988 The in vivo response to short-pulsed Nd-YAG laser damage to the trabecular meshwork has not been studied in the human eye. The nature of the response will determine the potential efficacy of this treatment for glaucoma. We have investigated short-pulsed la ... Link to item Cite

Mood and cognitive functions in anaesthetists working in actively scavenged operating theatres.

Journal Article Br J Anaesth · October 1988 Twenty-two anaesthetists participated in a study to assess the influence of occupational exposure to anaesthetic agents on mood (arousal and stress) and cognitive functions. In a cross-over design, each anaesthetist worked one day in a reference facility ( ... Full text Link to item Cite

B-lymphocytes from melanoma patients and normal individuals react with melanoma cells but also with irrelevant antigens.

Journal Article Br J Cancer · August 1988 Peripheral B-lymphocytes of 13 patients with uveal melanoma and of 5 healthy individuals were transformed with Epstein-Barr virus (EBV). The reactivity of these transformed cells with autologous or allogeneic melanoma cells and lymphocytes was measured by ... Full text Link to item Cite

Spectra of molecular changes induced in DNA of Drosophila spermatozoa by 1-ethyl-1-nitrosourea and X-rays.

Journal Article Mutation research · May 1988 Mutations induced in Drosophila spermatozoa at the alcohol dehydrogenase Adh locus by 1-ethyl-1-nitrosourea (ENU) were compared to X-ray-induced mutations using genetic tests for complementation, southern blotting, western blotting and northern blotting. 8 ... Cite

Experimental suprachoroidal plombage with a urethane based hydrophilic polymer.

Journal Article Br J Ophthalmol · April 1988 Small portions of dehydrated hydrophilic polymer (HPU 90, Smith and Nephew) have been inserted into the suprachoroidal space in rabbits to investigate the possible use of suprachoroidal plombage in retinal detachment surgery. As it hydrates, the material c ... Full text Link to item Cite

Molecular analysis of Drosophila melanogaster AdhnLA405 confirms reliability of DNA-sequencing methodology.

Journal Article Mutat Res · February 1988 An alcohol dehydrogenase (ADH) null mutant of Drosophila melanogaster (AdhnLA405) originally recovered following X-ray irradiation of mature sperm (Aaron, 979) is analyzed by Southern blotting, Western blotting, and DNA sequencing. The genetic, immunologic ... Full text Link to item Cite

Molecular analysis of alcohol dehydrogenase electromorphs in wild type and transformed Drosophila melanogaster.

Journal Article Biochem Biophys Res Commun · January 29, 1988 The protein expressed by the alcohol dehydrogenase locus (Adh) in D. melanogaster comprises a small group of electromorphs. We are able to study the expression of these electromorphs by electrophoretic separation and subsequent probing of blots of the sepa ... Full text Link to item Cite

Monoclonal antibodies to human primary uveal melanomas demonstrate tumor heterogeneity.

Journal Article Invest Ophthalmol Vis Sci · September 1986 Five rat monoclonal antibodies to human uveal melanoma were produced using primary tumor tissue for immunization and screening. These monoclonal antibodies were tested by enzyme-linked immunosorbent assay against 12 uveal melanomas, one breast carcinoma, a ... Link to item Cite

What should we do about work related cancer?

Journal Article Br Med J (Clin Res Ed) · May 3, 1986 Full text Link to item Cite