Scholars@Duke
Amir H. Rezvani

Amir H. Rezvani

Professor Emeritus in Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
azadi@duke.edu
Box 104790, Dept. of Psychiatry, Durham, NC 27710
323 Foster St., Durham, NC 27701
Office hours By appointment.  

Selected Publications

Acute and chronic glutamate NMDA antagonist treatment attenuates dopamine D1 antagonist-induced reduction of nicotine self-administration in female rats.

Journal Article Pharmacol Biochem Behav · January 2024 Multiple interacting neural systems are involved in sustaining nicotine reinforcement. We and others have shown that dopamine D1 receptors and glutamate NMDA receptors both play important roles in nicotine reinforcement. Blockade of D1 receptors with the a ... Full text Open Access Link to item Cite

Time-dependent effects of nicotine on reversal of dizocilpine-induced attentional impairment in female rats.

Journal Article Pharmacol Biochem Behav · April 2022 Nicotine and nicotinic compounds have been found to attenuate the attentional impairments caused by the glutamate NMDA antagonist dizocilpine (MK-801). The timing of the nicotine effect on attention in rodents has not yet been determined. In the current st ... Full text Open Access Link to item Cite

Chronic infusions of mecamylamine into the medial habenula: Effects on nicotine self-administration in rats.

Journal Article Behav Brain Res · January 7, 2022 The habenula is an epithalamic structure through which descending connections go from the telencephalon to the brainstem, putting it in a key location to provide feedback control over the ascending projections from the brainstem to the telencephalon. The m ... Full text Open Access Link to item Cite

Self-administration by female rats of low doses of nicotine alone vs. nicotine in tobacco smoke extract.

Journal Article Drug Alcohol Depend · November 1, 2021 BACKGROUND: Nicotine has reinforcing effects, but there are thousands of other compounds in tobacco, some of which might interact with nicotine reinforcement. AIMS: This rat study was conducted to determine if nicotine self-administration is altered by co- ... Full text Open Access Link to item Cite

Differential behavioral functioning in the offspring of rats with high vs. low self-administration of the opioid agonist remifentanil.

Journal Article Eur J Pharmacol · October 15, 2021 Opioid use disorder (OUD) has a variety of adverse effects on both the users and their offspring. In the current study, a random group of Sprague-Dawley rats (25 females and 15 males) were tested for intravenous self-administration of the opioid agonist re ... Full text Open Access Link to item Cite

Paternal cannabis extract exposure in rats: Preconception timing effects on neurodevelopmental behavior in offspring.

Journal Article Neurotoxicology · December 2020 Maternal toxicant exposure during gestation can have deleterious effects on neurobehavioral development of the offspring. The potential risks engendered by paternal toxicant exposure prior to conception have been largely understudied. Recently, we found th ... Full text Open Access Link to item Cite

Amitifadine, a triple reuptake inhibitor, reduces self-administration of the opiate remifentanil in rats.

Journal Article Psychopharmacology (Berl) · June 2020 RATIONALE: A variety of neural systems are involved in drug addiction, and some of these systems are shared across different addictive drugs. We have found several different types of drug treatments that successfully reduce nicotine self-administration. OB ... Full text Open Access Link to item Cite

Dextromethorphan and bupropion reduces high level remifentanil self-administration in rats.

Journal Article Pharmacol Biochem Behav · June 2020 Opiate addiction has risen substantially during the past decade. New treatments to combat opiate addiction are sorely needed. The current study was conducted to determine the acute individual and interactive effects of bupropion and dextromethorphan in a r ... Full text Open Access Link to item Cite

Paternal factors in neurodevelopmental toxicology: THC exposure of male rats causes long-lasting neurobehavioral effects in their offspring.

Journal Article Neurotoxicology · May 2020 The potential health risks of cannabis are of growing concern, including effects on reproduction and development. Extensive research has investigated risks associated with maternal exposure to THC during gestation and its impacts on the development of offs ... Full text Open Access Link to item Cite

Prolonging the Reduction of Nicotine Self-Administration in Rats by Coadministering Chronic Nicotine With Amitifadine, a Triple Monoamine Reuptake Inhibitor With CYP2B6 Inhibitory Actions.

Journal Article Nicotine Tob Res · February 6, 2020 INTRODUCTION: Existing treatments can aid tobacco smoking cessation, but they have low efficacy. Because there is a network of neural systems involved in tobacco addiction, combination treatments may provide greater efficacy. Chronic nicotine and amitifadi ... Full text Open Access Link to item Cite

Acute and chronic interactive treatments of serotonin 5HT2C and dopamine D1 receptor systems for decreasing nicotine self-administration in female rats.

Journal Article Pharmacol Biochem Behav · November 2019 A variety of neural systems are involved in the brain bases of tobacco addiction. Animal models of nicotine addiction have helped identify a variety of interacting neural systems involved in the pathophysiology of tobacco addiction. We and others have foun ... Full text Open Access Link to item Cite

Chronic memantine decreases nicotine self-administration in rats.

Journal Article Eur J Pharmacol · October 15, 2019 Neurobehavioral bases of tobacco addiction and nicotine reinforcement are complex, involving more than only nicotinic cholinergic or dopaminergic systems. Memantine is an NMDA glutamate antagonist used to improve cognitive function in people with Alzheimer ... Full text Open Access Link to item Cite

Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats.

Journal Article Pharmacol Biochem Behav · April 2019 Sazetidine-A selectively desensitizes α4β2 nicotinic receptors and also has partial agonist effects. We have shown that subcutaneous acute and repeated injections as well as chronic infusions of sazetidine-A significantly reduce intravenous (IV) nicotine s ... Full text Open Access Link to item Cite

α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats.

Journal Article Eur J Pharmacol · February 15, 2019 Sazetidine-A [6-(5(((S)-azetidine-2-yl)methoxy)pyridine-3-yl)hex-5-yn-1-ol] is a selective α4β2 nicotinic receptor desensitizing agent and partial agonist. Sazetidine-A has been shown in our previous studies to significantly reduce nicotine and alcohol sel ... Full text Open Access Link to item Cite

Persistent attenuation of nicotine self-administration in rats by co-administration of chronic nicotine infusion with the dopamine D1 receptor antagonist SCH-23390 or the serotonin 5-HT2C agonist lorcaserin.

Journal Article Pharmacol Biochem Behav · January 2019 Tobacco addiction each year causes millions of deaths worldwide. Brain nicotinic acetylcholine receptors have been shown to be central to tobacco addiction. Nicotine replacement therapy aids tobacco cessation, but the success rate is still far too low. Thi ... Full text Link to item Cite

Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring.

Journal Article Neurotoxicol Teratol · 2019 Developmental neurotoxicity of a wide variety of toxicants mediated via maternal exposure during gestation is very well established. In contrast, the impacts of paternal toxicant exposure on offspring neurobehavioral function are much less well studied. A ... Full text Open Access Link to item Cite

Paternal nicotine exposure in rats produces long-lasting neurobehavioral effects in the offspring.

Journal Article Neurotoxicol Teratol · 2019 Studies of intergenerational effects of parental chemical exposure have principally focused on maternal exposure, particularly for studies of adverse neurobehavioral consequences on the offspring. Maternal nicotine exposure has long been known to cause adv ... Full text Open Access Link to item Cite

Risk for opioid abuse is diminished by inhibiting aldehyde dehydrogenase-2 (ALDH-2) in rats

Journal Article Journal of Drug and Alcohol Research · January 1, 2019 Significant opiate addiction is known to follow prescribed opiate use for pain. There is a serious unmet need for non-addicting medications to prevent subsequent opiate addiction after a short period of opioid treatment for temporary pain. Recent evidence ... Full text Open Access Cite

Oral 18-Methoxycoronaridine (18-MC) Decreases Nicotine Self-Administration in Rats

Chapter · January 1, 2019 Tobacco addiction is a major problem worldwide with devastating health and socioeconomic consequences. Although several pharmacological treatments have been designed for combating this addiction, the development of more effective medications for the treatm ... Full text Cite

Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats.

Journal Article Neurosci Lett · March 6, 2018 Smoking cessation strategies are of prime medical importance. Despite availability of various pharmacological agents in combating addiction to nicotine, more effective medications are needed. Based on recent findings, the glutamatergic system in the brain ... Full text Link to item Cite

Mutually augmenting interactions of dextromethorphan and sazetidine-A for reducing nicotine self-administration in rats.

Journal Article Pharmacol Biochem Behav · March 2018 A variety of nicotinic drug treatments have been found to decrease nicotine self-administration. However, interactions of drugs affecting different nicotinic receptor subtypes have not been much investigated. This study investigated the interactions betwee ... Full text Link to item Cite

Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats.

Journal Article Psychopharmacology (Berl) · September 2017 RATIONALE AND OBJECTIVES: Desensitization of neuronal nicotinic acetylcholine receptors holds promise as an effective treatment of tobacco addiction. Previously, we found that sazetidine-A (Saz-A), which selectively desensitizes α4β2 nicotinic receptors, s ... Full text Link to item Cite

miR-149 and miR-29c as candidates for bipolar disorder biomarkers.

Journal Article Am J Med Genet B Neuropsychiatr Genet · April 2017 Bipolar disorder (BD) is a common, recurring psychiatric illness with unknown pathogenesis. Recent studies suggest that microRNA (miRNA) levels in brains of BD patients are significantly altered, and these changes may offer insight into BD pathology or eti ... Full text Link to item Cite

Ketamine Differentially Attenuates Alcohol Intake in Male Versus Female Alcohol Preferring (P) Rats.

Journal Article J Drug Alcohol Res · 2017 BACKGROUND: Although various pharmacological tools in combating addiction to alcohol are available, their efficacy is limited. Hence, there is a critical need for development of more effective medications. Recent advances in the field have identified the g ... Full text Open Access Link to item Cite

Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats.

Journal Article Psychopharmacology (Berl) · August 2016 RATIONALE: Chronic nicotine infusion via transdermal patches has been widely shown to assist with smoking cessation. In particular, transdermal nicotine treatment prior to quitting smoking helps reduce ad libitum smoking and aids cessation Rose et al. (Nic ... Full text Link to item Cite

Dextromethorphan interactions with histaminergic and serotonergic treatments to reduce nicotine self-administration in rats.

Journal Article Pharmacol Biochem Behav · March 2016 Combining effective treatments with diverse mechanisms of action for smoking cessation may provide better therapy by targeting multiple points of control in the neural circuits underlying addiction. Previous research in a rat model has shown that dextromet ... Full text Link to item Cite

Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administration

Journal Article Journal of Drug and Alcohol Research · January 1, 2016 Background. Alcohol and nicotine are commonly coabused. The search for a common core of neural, behavioral, and genetic factors underlying addiction has been the goal of addiction research. Purpose. Genetic predisposition to high alcohol intake has been st ... Full text Open Access Cite

Acute oral 18-methoxycoronaridine (18-MC) decreases both alcohol intake and IV nicotine self-administration in rats.

Journal Article Pharmacol Biochem Behav · 2016 The ibogaine derivative 18-methoxycoronaridine (18-MC) has been found to decrease self-administration of morphine, nicotine and alcohol in rats after systemic injection. However oral dosing is the preferred route clinically. The current study evaluated the ... Full text Link to item Cite

Brain Arachidonic Acid Incorporation and Turnover are not Altered in the Flinders Sensitive Line Rat Model of Human Depression.

Journal Article Neurochem Res · November 2015 Brain serotonergic signaling is coupled to arachidonic acid (AA)-releasing calcium-dependent phospholipase A2. Increased brain serotonin concentrations and disturbed serotonergic neurotransmission have been reported in the Flinders Sensitive Line (FSL) rat ... Full text Link to item Cite

Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats.

Journal Article Eur J Pharmacol · October 5, 2015 A wider diversity of drug treatments to aid smoking cessation is needed to help tailor the most efficacious treatment for different types of smokers. This study was conducted to determine whether amitifadine, which inhibits re-uptake of dopamine, norepinep ... Full text Link to item Cite

Heterogeneity across brain regions and neurotransmitter interactions with nicotinic effects on memory function.

Journal Article Curr Top Behav Neurosci · 2015 Nicotinic acetylcholine receptors have been shown in many studies to be critically involved in memory function. The precise roles these receptors play depend on the receptor subtype, their anatomic localization, their interactions with other parts of the n ... Full text Link to item Cite

Inhibition of aldehyde dehydrogenase-2 (ALDH-2) suppresses nicotine self-administration in rats

Journal Article Journal of Drug and Alcohol Research · January 1, 2015 Introduction. Aldehyde dehydrogenase-2 (ALDH-2) inhibitors have been shown to reduce cocaine and alcohol intake in rats. The mechanism of action appears to be due to inhibition of drug-induced dopamine (DA) production in the ventral tegmental area (VTA) an ... Full text Cite

Assessment of pregnenolone effects on alcohol intake and preference in male alcohol preferring (P) rats.

Conference Eur J Pharmacol · October 5, 2014 Neuroactive steroids can modulate a variety of neurobehavioral functions via the GABAergic system. This study was conducted to determine the importance of the neurosteroid pregnenolone on the regulation of alcohol intake. The effects of acute and chronic a ... Full text Link to item Cite

Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats.

Journal Article J Psychopharmacol · October 2014 Nicotine has been well characterized to improve memory and attention. Nicotine is the primary, but not only neuroactive compound in tobacco. Other tobacco constituents such as anabasine and anatabine also have agonist actions on nicotinic receptors. The cu ... Full text Link to item Cite

Lorcaserin, a selective 5-HT(2C) receptor agonist, decreases alcohol intake in female alcohol preferring rats.

Journal Article Pharmacol Biochem Behav · October 2014 Serotonergic systems in the brain have been found to be important in the addiction to alcohol. The purpose of this study was to evaluate the efficacy of a novel 5-HT2c receptor agonist, lorcaserin for reducing alcohol consumption in alcohol-preferring (P) ... Full text Link to item Cite

Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.

Journal Article J Med Chem · November 14, 2013 Developing novel and selective compounds that desensitize α4β2 nicotinic acetylcholine receptors (nAChRs) could provide new effective treatments for nicotine addiction, as well as other disorders. Here we report a new class of nAChR ligands that display hi ... Full text Link to item Cite

Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor β2-/- and α7-/- mice.

Journal Article Eur J Pharmacol · October 15, 2013 Nicotine elicits hypothermic responses in rodents. This effect appears to be related to nicotinic receptor desensitization because sazetidine-A, an α4β2 nicotinic receptor desensitizing agent, produces marked hypothermia and potentiates nicotine-induced hy ... Full text Link to item Cite

Effects of caffeine on alcohol consumption and nicotine self-administration in rats.

Journal Article Alcohol Clin Exp Res · September 2013 BACKGROUND: Caffeine, alcohol, and nicotine are 3 of the most widespread self-administered psychoactive substances, which are known to be extensively co-administered. However, little is known about the degree to which they may mutually potentiate each othe ... Full text Link to item Cite

Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.

Journal Article J Med Chem · April 11, 2013 Neuronal acetylcholine receptors mediate the addictive effects of nicotine and may also be involved in alcohol addiction. Varenicline, an approved smoking cessation medication, showed clear efficacy in reducing alcohol consumption in heavy-drinking smokers ... Full text Link to item Cite

Effects of chronic sazetidine-A, a selective α4β2 neuronal nicotinic acetylcholine receptors desensitizing agent on pharmacologically-induced impaired attention in rats.

Journal Article Psychopharmacology (Berl) · March 2013 Featured Publication RATIONALE: Nicotine and nicotinic agonists have been shown to improve attentional function. Nicotinic receptors are easily desensitized, and all nicotinic agonists are also desensitizing agents. Although both receptor activation and desensitization are com ... Full text Link to item Cite

Improvement of attentional function with antagonism of nicotinic receptors in female rats.

Journal Article Eur J Pharmacol · February 28, 2013 Featured Publication Nicotinic agonists have been shown in a variety of studies to improve cognitive function. Since nicotinic receptors are easily desensitized by agonists, it is not completely clear to what degree receptor desensitization or receptor activation are responsib ... Full text Link to item Cite

Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.

Journal Article J Pharmacol Exp Ther · November 2012 Featured Publication Chronic nicotine administration increases α4β2 neuronal nicotinic acetylcholine receptor (nAChR) density in brain. This up-regulation probably contributes to the development and/or maintenance of nicotine dependence. nAChR up-regulation is believed to be t ... Full text Link to item Cite

Effects of ethanol, Δ(9)-tetrahydrocannabinol, or their combination on object recognition memory and object preference in adolescent and adult male rats.

Journal Article Neurosci Lett · October 3, 2012 Featured Publication Recent advances have been made in our understanding of the deleterious effects of both ethanol and THC on adolescent behavior and brain development. However, very little is known about the combined effects of EtOH+THC during adolescence, a time in which th ... Full text Link to item Cite

Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats.

Journal Article Psychopharmacology (Berl) · October 2012 Featured Publication BACKGROUND AND RATIONALE: Nicotinic acetylcholine systems play major roles in cognitive function. Nicotine and a variety of nicotinic agonists improve attention, and nicotinic antagonist exposure impairs it. This study was conducted to investigate the effe ... Full text Link to item Cite

Novel medication targets for the treatment of alcoholism: preclinical studies.

Journal Article Recent Pat CNS Drug Discov · August 2012 Featured Publication Alcoholism is a complex heterogeneous disease and a number of neurotransmitter and neuromodulator systems have been implicated in its manifestation. Consequently, it is unlikely that existing medications such as disulfiram (Antabuse®), naltrexone (ReVia®), ... Full text Link to item Cite

Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats.

Journal Article Psychopharmacology (Berl) · July 2012 Featured Publication RATIONALE: Sazetidine-A is a selective α4β2 nicotinic receptor desensitizing agent and partial agonist. It has been shown in previous studies to significantly reduce nicotine self-administration in rats after acute or repeated injections. However, the effe ... Full text Link to item Cite

Alcohol and cognition - consideration of age of initiation, usage patterns and gender: a brief review.

Journal Article Curr Drug Abuse Rev · June 2012 Featured Publication Heavy alcohol use has numerous negative impacts on cognition. In many cases, it appears that excess drinking influences working memory, problem solving, attention, patterns of regional brain activation, and even gray and white matter volume. Due to these e ... Full text Link to item Cite

Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats.

Journal Article Eur J Pharmacol · May 5, 2012 Featured Publication Nicotine-induced hypothermia is well established, but the nicotinic receptor actions underlying this effect are not clear. Nicotine causes activation and desensitization at a variety of nicotinic receptor subtypes. Sazetidine-A [6-(5(((S)-azetidine-2-yl)me ... Full text Link to item Cite

Threshold of adulthood for the onset of nicotine self-administration in male and female rats.

Journal Article Behav Brain Res · December 1, 2011 Featured Publication The great majority of tobacco addiction begins during adolescence. More heavily addicted smokers begin smoking earlier, but differentiating the neurobehavioral impact of nicotine self-administration during adolescence from self-selection bias (whereby peop ... Full text Link to item Cite

The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety.

Journal Article Alcohol · September 2011 Featured Publication Neuropeptide Y (NPY) signaling has been shown to modulate stress responses and to be involved in regulation of alcohol intake and dependence. The present study explores the possibility that blockade of NPY Y2 autoreceptors using a novel, blood-brain barrie ... Full text Link to item Cite

Attention-modulating effects of cognitive enhancers.

Journal Article Pharmacol Biochem Behav · August 2011 Featured Publication Attention can be readily measured in experimental animal models. Animal models of attention have been used to better understand the neural systems involved in attention, how attention is impaired, and how therapeutic treatments can ameliorate attentional d ... Full text Link to item Cite

Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats.

Journal Article Psychopharmacology (Berl) · June 2011 Featured Publication BACKGROUND: Neuronal nicotinic receptor systems have been shown to play key roles in cognition. Nicotine and nicotinic analogs improve attention and nicotinic antagonists impair it. This study was conducted to investigate the role of α4β2 nicotinic recepto ... Full text Link to item Cite

JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats.

Journal Article Psychopharmacology (Berl) · April 2011 Featured Publication RATIONALE: A few recent studies suggest that brain histamine levels and signaling via H(3) receptors play an important role in modulation of alcohol stimulation and reward in rodents. OBJECTIVE: The present study characterized the effects of a novel, selec ... Full text Link to item Cite

Depressed-like behavior and alcohol drinking are co-morbid but independent in the fawn-hooded rats

Journal Article · December 1, 2010 The Fawn-Hooded (FH/Wjd) rat is an inbred strain that exhibits symptoms analogous to those exhibited by human depressives and alcoholics. The exaggerated swim test immobility and increased basal coticosterone levels are two of the depressed-like symptoms; ... Cite

Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats.

Journal Article Psychopharmacology (Berl) · August 2010 Featured Publication RATIONALE: Manipulations of nicotinic cholinergic receptors have been shown to influence both alcohol and nicotine intake. Sazetidine-A [6-(5(((S)-azetidine-2-yl)methoxy)pyridine-3-yl)hex-5-yn-1-ol] is a novel compound that potently and selectively desensi ... Full text Link to item Cite

Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats.

Journal Article J Pharmacol Exp Ther · March 2010 Featured Publication Adequate treatment of tobacco addiction remains problematic. Part of the problem with treatment is a poor understanding of the pharmacologic aspects of nicotine contributing to addiction. In addition to activating nicotinic acetylcholine receptors, nicotin ... Full text Link to item Cite

Persistent high alcohol consumption in alcohol-preferring (P) rats results from a lack of normal aversion to alcohol.

Journal Article Alcohol Alcohol · 2010 Featured Publication AIMS: In this study, we tested the impact of pretreatment with alcohol on subsequent alcohol drinking in outbred Sprague-Dawley and selectively bred alcohol-preferring (P) rats. METHODS: As a pretreatment, male Sprague-Dawley and P rats were given a passiv ... Full text Link to item Cite

Carisbamate, a novel antiepileptic candidate compound, attenuates alcohol intake in alcohol-preferring rats.

Journal Article Alcohol Clin Exp Res · August 2009 Featured Publication BACKGROUND: Since 1994, when naltrexone (Revia) was approved by the FDA for the treatment of alcoholism, only 2 other drugs (Campral and Topamax have been approved for alcoholism treatment. However, various experimental drugs, including antiepileptic medic ... Full text Link to item Cite

Antidepressant-like effects of nicotine and reduced nicotinic receptor binding in the Fawn-Hooded rat, an animal model of co-morbid depression and alcoholism.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · April 30, 2009 Featured Publication A strong positive association between depression and alcoholism is evident in epidemiological studies. Curiously, the incidence of smoking (nicotine intake) is also very high among depressed individuals. Because neuronal nicotinic receptors have been impli ... Full text Link to item Cite

Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · March 17, 2009 Featured Publication It is well established that nicotinic systems in the brain are critically involved in attentional processes in both animals and humans. The current study assessed the effects of a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist, R3487/ ... Full text Link to item Cite

Attenuation of pharmacologically-induced attentional impairment by methylphenidate in rats.

Journal Article Pharmacol Biochem Behav · March 2009 Featured Publication Methylphenidate is widely used as a treatment option for attention deficit hyperactivity disorder. In animal models of attentional impairment, it is an important validation to determine whether this clinically effective treatment attenuates deficits. The p ... Full text Link to item Cite

Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice.

Journal Article Behav Brain Res · January 23, 2009 Featured Publication Classically, it has been thought that high-affinity nicotinic receptors-containing beta2 subunits are the most important receptor subtypes for nicotinic involvement in cognitive function and nicotine self-administration, while low affinity alpha7-containin ... Full text Link to item Cite

Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats.

Journal Article Eur J Pharmacol · December 14, 2008 Featured Publication Nicotine intake constitutes a principal mechanism for tobacco addiction. In addition to primary effects on nicotinic acetylcholine receptors, nicotine has cascading effects, which may also underlie its neurobehavioral actions. Nicotine induces serotonin (5 ... Full text Link to item Cite

Neonatal 6-hydroxydopamine lesions of the frontal cortex in rats: persisting effects on locomotor activity, learning and nicotine self-administration.

Journal Article Neuroscience · June 26, 2008 Featured Publication Dopaminergic innervation of the frontal cortex in adults is important for a variety of cognitive functions and behavioral control. However, the role of frontal cortical dopaminergic innervation for neurobehavioral development has received little attention. ... Full text Link to item Cite

Liver genomic responses to ciguatoxin: evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice.

Journal Article Toxicol Sci · June 2008 Ciguatoxins (CTX) are polyether neurotoxins that target voltage-gated sodium channels and are responsible for ciguatera, the most common fish-borne food poisoning in humans. This study characterizes the global transcriptional response of mouse liver to a s ... Full text Link to item Cite

Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · May 15, 2008 Featured Publication Blockade of NMDA glutamate receptors with dizocilpine (MK-801) has been shown to cause substantial cognitive deficits and has been used to model symptoms of schizophrenia. Nicotine or nicotinic agonists, in contrast, may enhance cognitive or attentional fu ... Full text Link to item Cite

Early ethanol consumption predicts relapse-like behavior in adolescent male rats.

Journal Article Alcohol Clin Exp Res · May 2008 Featured Publication BACKGROUND: Alcohol abuse disorders emerge over time with repeated consumption of ethanol, but not all ethanol drinkers develop these disorders. There are pre-existing characteristics that indicate which drinkers are most likely to abuse alcohol. Adolescen ... Full text Link to item Cite

Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: relationship to blood ciguatoxin concentrations.

Journal Article Toxicology · April 3, 2008 Ciguatera is a common illness in tropical and subtropical regions that manifests in complex and long-lived symptoms which are more severe in subsequent exposures. This study measures central and peripheral neurologic signs, in parallel with blood toxin lev ... Full text Link to item Cite

Nicotine and clozapine effects on attentional performance impaired by the NMDA antagonist dizocilpine in female rats.

Journal Article Int J Neuropsychopharmacol · February 2008 Featured Publication Cognitive impairment is very prevalent in schizophrenia and is currently undertreated in most patients. Attentional deficit is one of the hallmark symptoms of schizophrenia. Antipsychotic drugs, which can be quite effective in combating hallucinations are ... Full text Link to item Cite

Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1.

Journal Article Neurotoxicology · November 2007 Ciguatoxins (CTX) are a suite of cyclic polyether toxins produced by the marine dinoflagellate Gambierdiscus sp., are potent activators of voltage-gated sodium channels and a leading cause of human poisoning from food fish. This report characterizes the ge ... Full text Link to item Cite

Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function.

Journal Article Biochem Pharmacol · October 15, 2007 Featured Publication People with schizophrenia often have substantial cognitive impairments, which may be related to nicotinic receptor deficits, (alpha7 and alpha4beta2), documented in the brains of people with schizophrenia. The large majority of people with schizophrenia sm ... Full text Link to item Cite

Further genetic characterization of the fawn-hooded (FH/Wjd) rat, an animal model of comorbid depression and alcoholism.

Journal Article Psychiatr Genet · April 2007 Featured Publication OBJECTIVE: The main objective of this study was a more detailed genetic characterization of the alcohol preferring fawn-hooded rat and its intercrosses. Fawn-hooded rats drink substantially more alcohol voluntarily than the ACI rats. The fawn-hooded rats w ... Full text Link to item Cite

Analysis of alcohol-related phenotypes in F2 progeny derived from FH/Wjd and ACI/N rat strains reveals independent measures and sex differences.

Journal Article Behav Brain Res · February 12, 2007 Featured Publication Ethanol associated addictive behaviors are governed by a combination of multiple gene action (polygenic or quantitative trait) and environmental factors. We produced F2 progeny from F1 crosses derived from the alcohol-preferring Fawn-Hooded (FH/Wjd) rat st ... Full text Link to item Cite

Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates.

Journal Article Neurotoxicol Teratol · 2007 Featured Publication Adolescence is the life stage when tobacco addiction typically begins. Adolescent neurobehavioral development may be altered by nicotine self-administration in a way that persistently potentiates addiction. Previously, we showed that female adolescent rats ... Full text Link to item Cite

Effects of atypical anxiolytic N-phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (JNJ-5234801) on alcohol intake in alcohol-preferring P rats.

Journal Article Alcohol Clin Exp Res · January 2007 Featured Publication BACKGROUND: N-Phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (JNJ-5234801) is a structurally novel atypical anxiolytic with an overall in vivo profile in animals suggestive of the potential to show anxiolytic efficacy in humans at doses ... Full text Link to item Cite

Depressive-like behavior and high alcohol drinking co-occur in the FH/WJD rat but appear to be under independent genetic control.

Journal Article Neurosci Biobehav Rev · 2007 Featured Publication This review will consider the evidence supporting the view that a specific substrain of Fawn-Hooded rat (FH/Wjd) exhibits co-occurring depressive-like behavior and high alcohol intake independently. First, the FH/Wjd rat is compared with other Fawn-Hooded ... Full text Link to item Cite

Modulation of high alcohol drinking in the inbred Fawn-Hooded (FH/Wjd) rat strain: implications for treatment.

Journal Article Addict Biol · September 2006 Featured Publication The Fawn-Hooded rat (FH/Wjd) is an inbred alcohol-preferring rat strain, unlike most of the other strains that were selectively bred for high alcohol intake and preference. It was chosen for study some 16 years ago because of a reported mutation that disru ... Full text Link to item Cite

Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization.

Journal Article Psychopharmacology (Berl) · March 2006 Featured Publication RATIONALE: Nicotine has been shown in a variety of studies in humans and experimental animals to improve cognitive function. Nicotinic treatments are being developed as therapeutic treatments for cognitive dysfunction. OBJECTIVES: Critical for the developm ... Full text Link to item Cite

Chronic nicotine interactions with clozapine and risperidone and attentional function in rats.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · March 2006 Featured Publication Although antipsychotic drugs are therapeutically effective in attenuating the hallmark symptoms of schizophrenia, these improvements do not return most patients to normative standards of cognitive function. Thus, complementary drug treatment may be needed ... Full text Link to item Cite

Involvement of the NMDA system in learning and memory

Chapter · January 1, 2006 Since its discovery in the early 1950s, the N-methyl-D-aspartate (NMDA) receptor system in the brain has been implicated in many fundamental functions, including neuronal plasticity, neurotoxicity, learning, and memory (Riedel et al., 2003). The aim of thi ... Full text Cite

Nicotinic-antipsychotic drug interactions and cognitive function.

Journal Article EXS · 2006 Featured Publication In summary, neuronal nicotinic systems are important for a variety of aspects of cognitive function impacted by antipsychotic drugs. It has been demonstrated that antipsychotic drugs have memory and attentional impairing effects when given to unimpaired su ... Full text Link to item Cite

Adolescent vulnerabilities to chronic alcohol or nicotine exposure: findings from rodent models.

Journal Article Alcohol Clin Exp Res · September 2005 Featured Publication This article presents an overview of the proceedings from a symposium entitled "Is adolescence special? Possible age-related vulnerabilities to chronic alcohol or nicotine exposure," organized by Susan Barron and Linda Spear and held at the 2004 Research S ... Full text Link to item Cite

Nicotinic-serotonergic drug interactions and attentional performance in rats.

Journal Article Psychopharmacology (Berl) · May 2005 Featured Publication RATIONALE: Both central serotonergic and nicotinic systems play important roles in a variety of neurobehavioral functions; however, the interactions of these two systems have not been fully characterized. The current study served to determine the impact of ... Full text Link to item Cite

Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding.

Journal Article Brain Res · April 18, 2005 Featured Publication Chronic nicotine administration has long been known to increase the number of high-affinity alpha4beta2 nicotinic receptors with lesser effects on low-affinity alpha7 nicotinic receptors. Nicotine has been shown to promote the release of a variety of neuro ... Full text Link to item Cite

Nicotine-antipsychotic drug interactions and attentional performance in female rats.

Journal Article Eur J Pharmacol · February 20, 2004 Featured Publication Schizophrenia is marked by pronounced cognitive impairments in addition to the hallmark psychotic symptoms like hallucinations. Antipsychotic drugs can effectively reduce these hallucinations; however, the drugs have not resolved the cognitive impairment. ... Full text Link to item Cite

Adolescent and adult rats respond differently to nicotine and alcohol: motor activity and body temperature.

Journal Article Int J Dev Neurosci · 2004 Featured Publication Alcohol and nicotine are the most widely abused drugs in the world. The use of these addictive drugs often begins in adolescence, however, little is known about the different impacts of nicotine and alcohol on adolescents versus adults. This study examined ... Full text Link to item Cite

Adolescent-onset nicotine self-administration modeled in female rats.

Journal Article Psychopharmacology (Berl) · September 2003 Featured Publication RATIONALE: Although the great majority of tobacco addiction begins during adolescence, little is known about differential nicotine effects in adolescents versus adults. OBJECTIVES: A rat model was used to determine the impact of the age of onset on nicotin ... Full text Link to item Cite

Nicotine-alcohol interactions and attentional performance on an operant visual signal detection task in female rats.

Journal Article Pharmacol Biochem Behav · August 2003 Featured Publication Nicotine and alcohol are very often co-used and co-abused. Thus, it is important to understand their interactions. In many ways, nicotine and alcohol have opposing effects. This can be clearly seen in terms of their effects on cognitive function. Nicotine ... Full text Link to item Cite

Plant derivatives in the treatment of alcohol dependency.

Journal Article Pharmacol Biochem Behav · June 2003 Featured Publication The present review summarizes the findings of the effects of extracts of purified compounds from several plants on alcohol intake in alcohol-preferring rats. These include St. John's wort (Hypericum perforatum, HPE), kudzu (Pueraria lobata) and ibogaine (T ... Full text Link to item Cite

Nicotinic-glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats.

Journal Article Eur J Pharmacol · March 28, 2003 Featured Publication Nicotinic systems have been shown to be critically involved in cognitive function including attention. Nicotine has been shown to improve performance on attentional tasks in humans with Alzheimer's disease, schizophrenia and attention deficit hyperactivity ... Full text Link to item Cite

Herbal remedies for alcoholism: promises and possible pitfalls.

Journal Article Alcohol Clin Exp Res · February 2003 Featured Publication This review summarizes the findings of the effects on alcohol intake in alcohol-preferring rats of extracts or purified compounds from two of the most promising herbs: kudzu (Pueraria lobata) and St. John's Wort (Hypericum perforatum). It is a summary of a ... Full text Link to item Cite

Autoradiographic quantification of neurochemical markers of serotonin, dopamine and opioid systems in rat brain mesolimbic regions following chronic St John's wort treatment.

Journal Article Naunyn Schmiedebergs Arch Pharmacol · February 2003 Featured Publication Effects of chronic treatment with St John's wort (SJW, Hypericum perforatum) on neurochemical markers of serotonin, dopamine and opioid systems in mesolimbic regions of the fawn-hooded rat were investigated by quantitative autoradiography. After 10 days' t ... Full text Link to item Cite

Effects of nicotine and mecamylamine on choice accuracy in an operant visual signal detection task in female rats.

Journal Article Psychopharmacology (Berl) · December 2002 Featured Publication RATIONALE: During the past decade, central nicotinic systems have been shown in both experimental animals and humans to play an important role in cognitive function. However, the way in which specific aspects of cognitive function are affected by nicotinic ... Full text Link to item Cite

Nicotinic treatment for cognitive dysfunction.

Journal Article Curr Drug Targets CNS Neurol Disord · August 2002 Featured Publication Nicotinic medications may provide beneficial therapeutic treatment for cognitive dysfunction such as Alzheimer's disease, schizophrenia and attention deficit hyperactivity disorder (ADHD). For development of nicotinic treatments we are fortunate to have a ... Full text Link to item Cite

Nicotine-alcohol interactions and cognitive function in rats.

Journal Article Pharmacol Biochem Behav · July 2002 Featured Publication Nicotine and ethanol are the most widely abused drugs in the world. They are very often used and abused together. However, little is known about the functional interaction of nicotine and ethanol. The current project studied the interactive effects of nico ... Full text Link to item Cite

The Fawn-Hooded (FH/Wjd) rat: a genetic animal model of comorbid depression and alcoholism.

Journal Article Psychiatr Genet · March 2002 Featured Publication The Fawn-Hooded (FH/Wjd) rat is an inbred strain of rat that has been reported to exhibit both high immobility in the forced swim test and high voluntary ethanol intake, measures that have been periodically linked with depression and alcoholism in humans. ... Full text Link to item Cite

Genetic selection of rats with high and low body temperatures.

Journal Article J Therm Biol · June 2001 Featured Publication Body (core) temperature (T(c)) directly affects all biological processes, including sensitivity to toxic chemicals, development, aging, and drug metabolism. To understand how T(c) affects these processes it is necessary to alter T(c) independently of other ... Full text Link to item Cite

Cognitive effects of nicotine.

Journal Article Biol Psychiatry · February 1, 2001 Featured Publication Nicotine and other nicotinic agonists have been found to improve performance on attention and memory tasks. Clinical studies using nicotine skin patches have demonstrated the efficacy of nicotine in treating cognitive impairments associated with Alzheimer' ... Full text Link to item Cite

Nicotinic involvement in cognitive function of rats

Chapter · January 1, 2001 Rat models have been very useful in demonstrating the effects of nicotinic agonist and antagonist on memory performance. Experimental rat models have been critical in providing the behavioral characterization of nicotinic effects on memory, as well as impo ... Cite

Specificity of cognitive impairment from Pfiesteria piscicida exposure in rats: attention and visual function versus behavioral plasticity.

Journal Article Neurotoxicol Teratol · 2001 Featured Publication Pfiesteria piscicida is a toxic dinoflagellate that has caused massive fish kills in estuaries along the East Coast of the United States, and exposure of humans to toxic Pfiesteria has been associated with cognitive impairment. A visual signal detection ta ... Full text Link to item Cite

Effects of sweetened ethanol solutions on ethanol self-administration and blood ethanol levels.

Journal Article Pharmacol Biochem Behav · January 2001 The enhancement of voluntary self-administration of ethanol by sucrose or saccharin was tested in conjunction with measurements of blood ethanol levels. Adult male rats were given access to both tap water and one of five solutions: 0.125% saccharin, 10% su ... Full text Link to item Cite

The nicotinic antagonist mecamylamine preferentially inhibits cocaine vs. food self-administration in rats.

Journal Article Physiol Behav · December 2000 Featured Publication Nicotinic acetylcholine systems play important roles in addiction, and nicotinic receptor stimulation stimulates dopamine release while the nicotinic antagonist mecamylamine reduces it. Reid et al. [Neuropsychopharmacology 20 (1999) 297.] recently found in ... Full text Link to item Cite

Independent segregation of alcohol intake and immobility in F2 progeny from FH/ ACI intercross

Journal Article American Journal of Medical Genetics - Neuropsychiatric Genetics · August 7, 2000 The inbred Fawn-Hooded (FH/Wjd) strain of rats not only drinks substantial amounts of alcohol voluntarily compared to the inbred ACI (ACI/N) strain, they also exhibit exaggerated immobility in the forced swim test (measurement for depression), have high sa ... Cite

Depressive characteristics of FSL rats: involvement of central nicotinic receptors.

Journal Article Pharmacol Biochem Behav · May 2000 Antidepressant effects of acute or chronic nicotine treatments in swim test immobility of Flinders sensitive line (FSL) rats, an animal model of depression, were recently demonstrated (Tizabi et al. Psychopharmacology 142:193, 1999). In the present study w ... Full text Link to item Cite

Development of nicotinic drug therapy for cognitive disorders.

Journal Article Eur J Pharmacol · March 30, 2000 Featured Publication Nicotine, as well as other nicotinic drugs, may provide useful therapeutic treatment for a variety of cognitive impairments including those found in Alzheimer's disease, schizophrenia and attention deficit hyperactivity disorder (ADHD). We have found that ... Full text Link to item Cite

Combination pharmacotherapy in alcoholism: a novel treatment approach.

Journal Article CNS Spectr · February 2000 Featured Publication Combination pharmacotherapy has proven effective in a number of psychiatric disorders, including depression and schizophrenia. However, compared with other affective disorders, few studies have explored the use of combination therapy in alcoholism, and the ... Full text Link to item Cite

Rapid neurobehavioral analysis of Pfiesteria piscicida effects in juvenile and adult rats.

Journal Article Neurotoxicol Teratol · 2000 Featured Publication The estuarine dinoflagellate Pfiesteria piscicida is known to kill fish and has been associated with neurocognitive deficits in humans. We have developed a rat model to demonstrate that exposure to Pfiesteria causes significant learning impairments. This h ... Full text Link to item Cite

Combination pharmacotherapy: a mixture of small doses of naltrexone, fluoxetine, and a thyrotropin-releasing hormone analogue reduces alcohol intake in three strains of alcohol-preferring rats.

Journal Article Alcohol Alcohol · January 2000 Featured Publication It is common to treat some diseases with more than one medication simultaneously. Since more than one neurotransmitter system is involved in alcohol-seeking behaviour, then a therapeutic approach that targets more than one system should be more effective i ... Full text Link to item Cite

Suppression of alcohol intake by chronic naloxone treatment in P rats: tolerance development and elevation of opiate receptor binding.

Journal Article Alcohol Clin Exp Res · November 1999 Featured Publication BACKGROUND: This study was planned to determine the feasibility of using a slow release naloxone preparation to treat alcoholism, because compliance with medication is a significant problem in alcoholics. METHODS: Experiments were performed in alcohol-pref ... Link to item Cite

Chinese herb may help to treat alchohol addiction: Commentary

Journal Article Forschende Komplementarmedizin · October 11, 1999 Cite

Ethanol consumption by Fawn-Hooded rats following abstinence: effect of naltrexone and changes in mu-opioid receptor density.

Journal Article Alcohol Clin Exp Res · June 1999 Featured Publication BACKGROUND: Relapse after abstinence can be modelled in rats using an alcohol deprivation effect (ADE) of enhanced ethanol consumption after a period of enforced abstinence from ethanol; however, not all rat strains display such an effect. We wanted to exa ... Link to item Cite

Antidepressant effects of nicotine in an animal model of depression.

Journal Article Psychopharmacology (Berl) · February 1999 Featured Publication Epidemiological studies indicate a high incidence of cigarette smoking among depressed individuals. Moreover, individuals with a history of depression have a much harder time giving up smoking. It has been postulated that smoking may reflect an attempt at ... Full text Link to item Cite

Behavioural features of alcohol-preferring rats: focus on inbred strains.

Journal Article Alcohol Alcohol · 1999 Featured Publication A recent study conducted a factor analysis on 18 behavioural measures obtained from four alcohol-preferring and five alcohol-non-preferring rat lines/strains. It was concluded that variables such as saccharin intake, ultrasonic vocalizations following an a ... Full text Link to item Cite

Attenuation of alcohol intake by extract of Hypericum perforatum (St. John's Wort) in two different strains of alcohol-preferring rats.

Journal Article Alcohol Alcohol · 1999 Featured Publication Extract of the common plant Hypericum perforatum L. (St John's Wort, SJW) has been used successfully for the treatment of mild to moderate depression since ancient times and has recently been studied clinically. Depression and alcoholism have some neuroche ... Full text Link to item Cite

Distribution of opioid peptide gene expression in the limbic system of Fawn-Hooded (alcohol-preferring) and Wistar-Kyoto (alcohol-non-preferring) rats.

Journal Article Brain Res · June 15, 1998 Preprodynorphin and preproenkephalin mRNA expression was examined in the CNS of two rat strains, the alcohol-preferring Fawn-Hooded (FH) and the alcohol-non-preferring Wistar-Kyoto (WKY), using in situ hybridisation histochemistry. Relative to the WKY, the ... Full text Link to item Cite

Distribution of GABAA receptors in the limbic system of alcohol-preferring and non-preferring rats: in situ hybridisation histochemistry and receptor autoradiography.

Journal Article Neurochem Int · February 1998 The present study has employed quantitative receptor autoradiography and in situ hybridisation histochemistry to compare the expression of the mRNA encoding the alpha 1 and alpha 2 subunits of the GABAA receptor and the binding density of mature GABAA rece ... Full text Link to item Cite

[3H]zolpidem binding in alcohol-preferring and non-preferring rat brain.

Journal Article Neurosci Lett · December 5, 1997 The present study has employed in vitro autoradiography to study the distribution and density of [3H]zolpidem binding sites, which are regarded as an index of ethanol-sensitive gamma-aminobutyric acid (GABA)A receptors, in the brains of alcohol-preferring ... Full text Link to item Cite

Involvement of dopamine D2 receptors in the suppressive effect of the thyrotropin-releasing hormone analog TA-0910 on alcohol intake in alcohol-preferring rats.

Journal Article Alcohol Clin Exp Res · December 1997 Pharmacological experiments were conducted to determine the neuronal mechanisms involved in the suppressive effects of the thyrotropin-releasing hormone analog TA-0910 on alcohol intake in alcohol-preferring (P) rats. We previously reported that single int ... Link to item Cite

Selective inhibition of alcohol intake in diverse alcohol-preferring rat strains by the 5-HT2A antagonists amperozide and FG 5974.

Journal Article Alcohol Clin Exp Res · November 1997 The present studies sought to elucidate the role of 5-HT2A receptor antagonists in suppressing alcohol intake by comparing the effects of amperozide and FG 5974 on alcohol, food, and water intake in strains of alcohol-preferring rats: P, Alko Alcohol (AA), ... Link to item Cite

Attenuation of alcohol consumption by a novel nontoxic ibogaine analogue (18-methoxycoronaridine) in alcohol-preferring rats.

Journal Article Pharmacol Biochem Behav · October 1997 We previously reported that single administration of ibogaine, an indol alkaloid with antiaddictive properties, dose dependently reduced alcohol intake in three strains of alcohol-preferring rats. The present study examined the effect of different doses of ... Full text Link to item Cite

Ultrasonic vocalization behavior differs between lines of ethanol-preferring and nonpreferring rats.

Journal Article Alcohol Clin Exp Res · October 1997 To further understand the relationship between emotional state and alcohol intake in rats, the tendency to emit ultrasonic vocalizations in response to an aversive, but nonpainful, air puff stimulus was tested in several rat lines. Included in this group w ... Link to item Cite

Fluoxetine reduces saccharin-induced elevation of fluid intake in alcohol-preferring Fawn-Hooded rats.

Journal Article Pharmacol Biochem Behav · September 1997 Previous work has established that saccharin and alcohol intakes are highly correlated in a variety of rat strains. In addition, it has been shown that alcohol-preferring rats consume saccharin beyond the limit of their normal daily fluid intake (DFI). It ... Full text Link to item Cite

Behavioral similarities and differences among alcohol-preferring and -nonpreferring rats: confirmation by factor analysis and extension to additional groups.

Journal Article Alcohol Clin Exp Res · August 1997 Thirteen behavioral variables from six tasks were measured in alcohol-preferring (AA, FH, and P) and -nonpreferring (ANA, FRL, and NP) rat lines/strains and subjected to Factor Analysis. Four Independent factors accounted for > 90% of the variance. Defecat ... Link to item Cite

Thyrotropin releasing hormone analog TA-0910 suppresses alcohol intake in alcohol drinking African green monkeys.

Journal Article Alcohol Clin Exp Res · April 1997 In previous studies, we found that single injections of the thyrotropin-releasing hormone analog TA-0910 dose-dependently reduced alcohol intake and preference in alcohol-preferring (P) and Fawn-Hooded (FH) rats over a 24-hr period of continuous access to ... Link to item Cite

Behavioral differences between two inbred strains of Fawn-Hooded rat: a model of serotonin dysfunction.

Journal Article Psychopharmacology (Berl) · December 1996 The Fawn-Hooded rat (FH) strain has attracted the attention of some psychopharmacologists because of reports of its exaggerated immobility in the swim test, hypercortisolemia, excessive voluntary intake of alcohol, platelet and central serotonin abnormalit ... Full text Link to item Cite

Thyrotropin-releasing hormone analog TA-0910 reduces voluntary alcohol intake of P rats subchronically in a limited scheduled access paradigm.

Journal Article Alcohol Clin Exp Res · September 1996 We previously reported that single intraperitoneal injections of the thyrotropin-releasing hormone analog TA-0910 dose-dependently reduce alcohol intake in alcohol-preferring (P) rats in a free-choice continuous access protocol. We later showed, using the ... Full text Link to item Cite

Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives.

Journal Article Alcohol Clin Exp Res · April 1996 The Chinese herbal medicine, NPI-028, has been used for centuries in China to counteract alcohol intoxication. The present study used a number of different experimental conditions to determine whether NPI-028 and its derivatives might selectively influence ... Full text Link to item Cite

Role of taste aversion in calcium channel inhibitor-induced suppression of saccharin and alcohol drinking in rats.

Journal Article Physiol Behav · February 1996 L-type calcium (Ca2+) channel inhibitors suppress drinking of highly preferred solutions of simple carbohydrates, saccharin, or alcohol. The present study was designed to examine whether this decrease in drinking behavior can be explained by the developmen ... Full text Link to item Cite

Further selection of rat lines differing in 5-HT-1A receptor sensitivity: behavioral and functional correlates.

Journal Article Psychiatr Genet · 1996 It was previously reported that selection for differences in the hypothermic effects to the selective 5-HT-1A agonist, 8-OH-DPAT, occurred rapidly, with very substantial differences present by the fourth generation. The present communication summarizes the ... Full text Link to item Cite

Pain sensitivity and saccharin intake in alcohol-preferring and -nonpreferring rat strains.

Journal Article Physiol Behav · 1996 The experiments were designed to study the association between consumption of palatable 0.1% (w/v) saccharin solution, voluntary drinking of 10% (v/v) ethanol solution, and pain sensitivity measured with the hot plate test. Rat lines that were genetically ... Full text Link to item Cite

Attenuation of alcohol intake by ibogaine in three strains of alcohol-preferring rats.

Journal Article Pharmacol Biochem Behav · November 1995 Alcohol-preferring (P), Fawn-Hooded (FH) and alcohol-accepting (AA) rats were injected intraperitoneally (IP) or subcutaneously (SC) with different doses (10, 30, and 60 mg/kg) of Ibogaine or vehicle. In a separate experiment, FH rats were administered int ... Full text Link to item Cite

Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression.

Journal Article Psychopharmacology (Berl) · September 1995 Flinders Sensitive Line (FSL) rats have been proposed as an animal model of depression because they resemble depressed humans in that they have elevated REM sleep, reduced activity, and increased immobility and anhedonia after exposure to stressors. The pr ... Full text Link to item Cite

Suppression of ethanol intake in alcohol-preferring rats by prior voluntary saccharin consumption.

Journal Article Pharmacol Biochem Behav · September 1995 In a situation offering a free choice between 0.1% saccharin solution and tap water, Fawn Hooded (FH) rats consumed 363.0 +/- 33.5 ml/kg/day of saccharin solution. Subsequently those animals drank 3.0 +/- 0.4 g/kg of ethanol in a free choice between water ... Full text Link to item Cite

Saccharin-induced increase in daily fluid intake as a predictor of voluntary alcohol intake in alcohol-preferring rats.

Journal Article Physiol Behav · April 1995 This study examined the relationship between saccharin intake and ethanol consumption in alcohol preferring (P) rats and Fawn Hooded (FH) rats before and after exposure to forced ethanol (10%, v/v) solution. Both groups exhibited large increases (> 2X) in ... Full text Link to item Cite

Inhibition of nitric oxide synthesis attenuates alcohol consumption in two strains of alcohol-preferring rats.

Journal Article Pharmacol Biochem Behav · February 1995 The effect of the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on voluntary alcohol consumption was examined in two different strains of alcohol-preferring rats, in a continuous-access, two-bottle-choice paradigm. Compared with ... Full text Link to item Cite

Effects of chronic mild stress on serum complement activity, saccharin preference, and corticosterone levels in Flinders lines of rats.

Journal Article Physiol Behav · January 1995 Complement proteins and fragments participate in the induction and modulation of specific and nonspecific immune reactions. We have examined the effect of 4 weeks of chronic mild stress (CMS) on complement sheep red blood cell hemolytic activity measured i ... Full text Link to item Cite

The subchronic effects of the TRH analog TA-0910 and bromocriptine on alcohol preference in alcohol-preferring rats: development of tolerance and cross-tolerance.

Journal Article Alcohol Clin Exp Res · October 1994 In a previous study, we showed that a single injection of the thyrotropin-releasing hormone analog TA-0910 dose-dependently reduced alcohol intake in alcohol-preferring (P) rats and increased their water intake over a 24-hr period. In the present study, th ... Full text Link to item Cite

Effects of ethanol, MK-801, and chlordiazepoxide on locomotor activity in different rat lines: dissociation of locomotor stimulation from ethanol preference.

Journal Article Alcohol Clin Exp Res · August 1994 Several lines of research have suggested a link between the reward value of a drug and its ability to stimulate locomotion. One goal of the present study was to determine whether ethanol preferentially stimulates locomotor activity in lines of rat that sho ... Full text Link to item Cite

Calcium channel inhibitors attenuate consumption of ethanol, sucrose and saccharin solutions in rats.

Journal Article Behav Pharmacol · August 1994 Ca(2+) channel inhibitors suppress ethanol intake in various strains of alcohol-preferring rats. To test whether that inhibitory effect involves interference with the caloric consequences of preferred fluids, we compared the effects of two dihydropyridines ... Full text Link to item Cite

Autonomic and behavioral responses of selectively bred hypercholinergic rats to oxotremorine and diisopropyl fluorophosphate.

Journal Article Pharmacol Biochem Behav · July 1994 The hypercholinergic Flinders Sensitive Line (FSL) rat was significantly more sensitive than the Flinders Resistant Line (FRL) rat to the biotelemetrically recorded hypothermic effects of oxotremorine, a direct-acting muscarinic agonist, and diisopropyl fl ... Full text Link to item Cite

Suppression of alcohol consumption by fenfluramine in Fawn-Hooded rats with serotonin dysfunction.

Journal Article Pharmacol Biochem Behav · May 1994 The high preference for alcohol intake observed in Fawn-Hooded rats has been attributed to the central serotonin (5-HT) dysfunction in this strain. To further characterize the involvement of 5-HT in alcohol-seeking behavior in Fawn-Hooded rats, the effect ... Full text Link to item Cite

5-HT receptors: implications for the neuropharmacology of alcohol and alcoholism.

Journal Article Alcohol Alcohol Suppl · 1994 The involvement of serotonergic mechanisms in the neuropharmacology of alcohol was appreciated before it was recognized that there were multiple subtypes of serotonin (5-hydroxytryptamine; 5-HT) receptors. Thus, it was known that manipulations of the centr ... Link to item Cite

Rapid selection for serotonin-1A sensitivity in rats.

Journal Article Psychiatr Genet · 1994 National Institutes of Health (NIH) heterogeneous stock (HS) rats were obtained and genetically selected for either larger (HI line) or smaller (LO line) hypothermic responses to the selective serotonin-1A (5-HT1A) agonist 8-hydroxy-2-(di-N-propylamino)tet ... Full text Link to item Cite

Swim test immobility co-segregates with serotonergic but not cholinergic sensitivity in cross-breeds of Flinders Line rats.

Journal Article Psychiatr Genet · 1994 The Flinders Sensitive Line (FSL) rat, a genetic animal model of depression, was cross-bred with its normal control, the Flinders Resistant Line (FRL) rat, in order to investigate the relationship between cholinergic sensitivity, the selected variable, and ... Full text Link to item Cite

Chronic mild stress-induced anhedonia: greater effect in a genetic rat model of depression.

Journal Article Physiol Behav · December 1993 The effects of acute and chronic stressors on saccharin intake and preference in the hypercholinergic Flinders Sensitive Line (FSL) rat, a putative genetic animal model of depression, were studied and compared to the control Flinders Resistant Line (FRL) r ... Full text Link to item Cite

Reduction of spontaneous alcohol drinking and physical withdrawal by levemopamil, a novel Ca2+ channel antagonist, in rats.

Journal Article Pharmacol Biochem Behav · October 1993 Neuronal Ca2+ channels have been shown to be involved in both alcohol drinking behavior in rats and nonhuman primates and in the manifestation of alcohol withdrawal symptoms in rodents. Experiments were performed to determine the effect of a single injecti ... Full text Link to item Cite

Verapamil suppresses d-amphetamine-induced place preference conditioning.

Journal Article Eur J Pharmacol · August 10, 1993 The effect of pretreatment with (+/-)-verapamil (5, 10 or 15 mg/kg, i.p.) on place preference induced with d-amphetamine (1 mg/kg, i.p. 40 min after verapamil) was studied in male rats. Place preference conditioning was performed using two-compartment shut ... Full text Link to item Cite

Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains.

Journal Article Alcohol Clin Exp Res · April 1993 Saccharin and ethanol intakes were measured in seven strains of rats known to differ in their preferences for ethanol: The Fawn-Hooded (FH), alcohol-preferring (P) and Maudsley Reactive rats have been reported to drink ethanol voluntarily, whereas the alco ... Full text Link to item Cite

Attenuation of alcohol consumption by MDMA (ecstasy) in two strains of alcohol-preferring rats.

Journal Article Pharmacol Biochem Behav · September 1992 Alcohol preference and manifestation of alcoholism are thought by many to be associated with serotonin (5-HT) dysfunction in the brain. Thus, experiments were performed to determine the effect of acute and subchronic administration of (+/-) 3,4-methylenedi ... Full text Link to item Cite

Maudsley reactive and nonreactive rats differ only in some tasks reflecting emotionality.

Journal Article Physiol Behav · July 1992 The behavior of Maudsley reactive and nonreactive rats, along with that of Wistar controls, was studied using three behavioral tasks which have been associated with emotionality. Consistent with the hypothesis that they are more emotional, the Maudsley rea ... Full text Link to item Cite

Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism.

Journal Article Biol Psychiatry · May 1, 1992 The present article summarizes some comparative studies of the Fawn-Hooded (FH) rat, a potential animal model of ethanol preference, and the Flinders Sensitive Line (FSL) rat, a potential animal model of depression. Both FH and FSL rats exhibit high degree ... Full text Link to item Cite

Attenuation of alcohol preference in alcohol-preferring rats by a novel TRH analogue, TA-0910.

Journal Article Alcohol Clin Exp Res · April 1992 Experiments were performed to characterize the acute effect of different doses of a novel thyrotropin-releasing hormone (TRH) analogue (TA-0910) on ethanol intake in rats. Selectively bred alcohol-preferring (P) rats received a single intraperitoneal injec ... Full text Link to item Cite

Ethanol and complement hemolytic activity of selectively bred hypercholinergic rats.

Journal Article Alcohol Alcohol · January 1992 Depression and alcoholism are associated with impaired immune responses. Complement proteins and fragments participate in the induction and modulation of both specific and non-specific immune reactions. This study examined the effect of prolonged ethanol i ... Link to item Cite

Suppression of alcohol and saccharin preference in rats by a novel Ca2+ channel inhibitor, Goe 5438.

Journal Article Psychopharmacology (Berl) · 1992 The effect of the novel 1,4-dihydronaphthyridine Ca2+ channel inhibitor Goe 5438 (CI-951) on voluntary ethanol consumption was examined in selectively bred alcohol-preferring (P) rats in a free choice two bottle preference test versus water. Intraperitonea ... Full text Link to item Cite

Effects of calcium channel inhibitors on the hypothermic response to oxotremorine in normo and hypercholinergic rats.

Journal Article J Pharm Pharmacol · June 1991 The Flinders Sensitive Line of rats (FSL) has been selectively bred to have increased sensitivity to cholinergic drugs. Typically, these rats react with twice as great a hypothermic effect to muscarinic agonists such as oxotremorine, as do similarly bred F ... Full text Link to item Cite

Decreased hyperthermic effect of MK-801 in selectively bred hypercholinergic rats.

Journal Article Brain Res Bull · April 1991 The Flinders Sensitive Line (FSL) of rats has been selectively bred to have increased sensitivity to cholinergic agonists. However, these rats exhibit altered responsiveness to a number of noncholinergic agents, such as apomorphine, buspirone and ethanol. ... Full text Link to item Cite

Alterations in the hypothalamic-pituitary-adrenal axis in a proposed animal model of depression with genetic muscarinic supersensitivity.

Journal Article Neuropsychopharmacology · February 1991 Rats from the Flinders Sensitive Line (FSL) and Flinders Resistant Line (FRL), which have been bred for differences in sensitivity to cholinergic agonists, were killed by decapitation under quiet, nonstressful conditions and the concentrations of corticotr ... Link to item Cite

Drug-induced reductions in ethanol intake in alcohol preferring and Fawn-Hooded rats.

Journal Article Alcohol Alcohol Suppl · 1991 The ethanol intake of Fawn-Hooded rats, a serotonin deficient strain, was examined under a two bottle choice between ethanol (10%) and tap water. The Fawn-Hooded rats drank as much ethanol as the alcohol preferring strain of rats (approximately 6 times tha ... Link to item Cite

Effect of calcium-channel blockers on alcohol consumption in alcohol-drinking monkeys.

Journal Article Alcohol Alcohol · 1991 Experiments were performed to determine the effect of the calcium-channel blockers verapamil and diltiazem on ethanol preference in monkeys. Two days of administration of 10 mg/kg verapamil but not diltiazem or saline significantly decreased ethanol intake ... Full text Link to item Cite

Effect of verapamil on submissive behavior in genetically bred hypercholinergic rats in a water competition test.

Journal Article Eur J Pharmacol · October 23, 1990 Male hypercholinergic FSL (Flinders Sensitive Line) and control FRL (Flinders Resistant Line) rats were placed on a water deprivation schedule and tested for dominance behavior with FSL/FRL pairs competing for water. FSL rats spent significantly less time ... Full text Link to item Cite

Effects of bright light on responsiveness to a muscarinic agonist in rats selectively bred for endogenously increased cholinergic function.

Journal Article Psychiatry Res · August 1990 The Flinders Sensitive Line (FSL) was derived from the Sprague-Dawley rat by selectively breeding those animals exhibiting a high level of sensitivity to an anticholinesterase. The Flinders Resistant Line (FRL) was simultaneously developed as a control lin ... Full text Link to item Cite

Impaired active avoidance responding in rats selectively bred for increased cholinergic function.

Journal Article Physiol Behav · April 1990 It was found that the Flinders Sensitive Line (FSL) of rat, selectively bred for increased cholinergic function, performed poorly in a tone-cued two-way active avoidance task in comparison with the control Flinders Restraint Line (FRL) of rat. These findin ... Full text Link to item Cite

Neurotensin-induced dopamine release in vivo and in vitro from substantia nigra and nucleus caudate.

Journal Article J Pharmacol Exp Ther · February 1990 We compared the dopamine (DA) releasing effects of neurotensin (NT) from cell bodies (substantia nigra) and nerve terminals (nucleus caudate). In rats implanted with push-pull cannula, NT induced DA release from substantia nigra and nucleus caudate. NT was ... Link to item Cite

MK-801 potently inhibits alcohol withdrawal seizures in rats.

Journal Article Eur J Pharmacol · January 25, 1990 The ability of MK-801, an N-methyl-D-aspartate (NMDA)-channel antagonist, to suppress alcohol withdrawal seizures generated audio-genically was studied in adult male rats using a cross-over experimental design. MK-801 treatment reduced overall seizure scor ... Full text Link to item Cite

Selective antagonistic effects of exposure to bright light on the hypothermic action of ethanol.

Journal Article Alcohol Alcohol · 1990 Flinders Sensitive and Resistant Lines of rats, which are differentially sensitive to the hypothermic effects of both muscarinic agonists and ethanol, were exposed to full spectrum artificial bright light for eight days, because exposure to bright light ha ... Full text Link to item Cite

Reduction in ethanol preference following injection of centrally and peripherally acting antimuscarinic agents.

Journal Article Alcohol Alcohol · 1990 Selectively bred alcohol-preferring (P) and alcohol non-preferring (NP) lines of rats were administered saline subcutaneously, and doses of 0.5 and 2.0 mg/kg of two antimuscarinic agents scopolamine (centrally acting) and methscopolamine (peripherally acti ... Link to item Cite

Enhanced affective aggression in genetically bred hypercholinergic rats.

Journal Article Neuropsychobiology · 1990 Affective aggression was studied in pairs of Flinders Sensitive Line hypercholinergic rats (FSL) and Flinders Resistant Line (FRL) rats in shock-induced and apomorphine-induced fighting tests. FSL rats were significantly more aggressive in both tests. They ... Full text Link to item Cite

Verapamil effects on physiological and behavioral responses to ethanol in the rat.

Journal Article Alcohol Alcohol · 1990 Experiments were performed to determine the ability of verapamil to reverse ethanol-induced hypothermia and behavioral changes. Permanent cannulae for intracerebroventricular (i.c.v.) infusion were implanted bilaterally in rats following standard stereotax ... Link to item Cite

Increased hypothermic responses to ethanol in rats selectively bred for cholinergic supersensitivity.

Journal Article Alcohol Alcohol · 1990 The behavioral and hypothermic effects of ethanol were studied in the Flinders Sensitive Line (FSL) and Flinders Resistant Line (FRL) rats, selectively bred for differences in cholinergic sensitivity. The FSL hypercholinergic rats exhibited a significantly ... Link to item Cite

Decreased alcohol consumption by verapamil in alcohol preferring rats.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · 1990 1. Calcium channel blockers have been proposed, in addition to inhibiting the influx of Ca++ into the cells, to possess a wide variety of pharmacological effects, including interference with certain neurotransmitters involved in mood, mental disorders and ... Full text Link to item Cite

Immunologic consequences of acute ethanol ingestion in rats.

Journal Article J Surg Res · November 1989 Acute ethanol (EtOH) intoxication is commonly associated with many medical and surgical problems which primarily or secondarily involve infection. Chronic EtOH ingestion has been associated with immune dysfunction and an increased risk of infection; howeve ... Full text Link to item Cite

Measurement of extracellular calcium ions within the hypothalamus of the freely-moving cat: A novel approach

Journal Article Journal of Liquid Chromatography · June 1, 1989 In order to investigate the kinetics of calcium ion (Ca++) activity within the hypothalamus by high performance liquid chromatography, standard push-pull guide cannulae were implanted stereotaxically above the hypothalamus of the cat. Following post-operat ... Full text Cite

Alcoholism and depressive disorders: is cholinergic sensitivity a biological marker?

Journal Article Alcohol Alcohol · 1989 There is an overlap between alcoholism and depressive disorders. However, alcoholics tend to be resistant to the effect of cholinergic agonists, whereas depressives tend to be more sensitive. A recently developed animal model of depression which is more se ... Link to item Cite

Temperature regulation in laboratory mammals following acute toxic insult.

Journal Article Toxicology · December 30, 1988 The purpose of this paper is to provide a concise review of the effects of acute chemical toxicity on thermoregulation in mammals, with particular emphasis on the effects of xenobiotic compounds in laboratory rodents. It has been shown that acute administr ... Full text Link to item Cite

Behavioral thermoregulation in the rat following the oral administration of ethanol.

Journal Article Alcohol Alcohol · 1988 To assess if ethyl alcohol (ethanol) causes a reduction in the set-point for control of body temperature, behavioral thermoregulatory responses in the Fischer rat were measured following a single oral administration of ethanol. In a preliminary study, five ... Full text Link to item Cite

Rostral hypothalamus: a new neuroanatomical site of neurochemically-induced emesis in the cat.

Journal Article Brain Res Bull · August 1987 The localized effect of noradrenergic agonists administered directly in the anterior hypothalamic preoptic area (AH/POA) in inducing emesis in the cat was investigated. Of the noradrenergic agonists tested, which included norepinephrine, clonidine, phenyle ... Full text Link to item Cite

Hypothermia: role of alpha 1- and alpha 2-noradrenergic receptors in the hypothalamus of the cat.

Journal Article Pharmacol Biochem Behav · February 1987 The purpose of this study was to characterize the alpha 1- and alpha 2-noradrenergic receptor sub-types which could mediate the hypothermic response produced by norepinephrine (NE) and other alpha-noradrenergic agonists applied to the thermosensitive zone ... Full text Link to item Cite

Neurotensin releases norepinephrine differentially from perfused hypothalamus of sated and fasted rat.

Journal Article Am J Physiol · January 1987 The central injection of neurotensin (NT) has been reported to attenuate the intake of food in the fasted animal. To determine whether endogenous norepinephrine (NE) is involved in the satiating effect of NT, the in vivo activity of NE in circumscribed sit ... Full text Link to item Cite

Rate of in vivo verapamil exchange within the hypothalamus of the cat as examined by push-pull perfusion.

Journal Article Neurochem Res · December 1986 To investigate the characteristics of the uptake within hypothalamic tissue of the Ca2+-channel blocker, verapamil, push-pull canulae were implanted bilaterally above the anterior hypothalamic-preoptic area (AH/POA) and posterior hypothalamus (PH) of the c ... Full text Link to item Cite

Dissociation of locomotor impairment from mydriasis evoked by clonidine injected into cat's rostral hypothalamus.

Journal Article Brain Res Bull · September 1986 The anterior hypothalamic preoptic area (AH/POA) was examined as a possible site of action of clonidine and other alpha noradrenergic receptor agonists which evoke motor and autonomic changes. Chronically indwelling guide cannulae were implanted stereotaxi ... Full text Link to item Cite

Neuroanatomical mapping of hypothalamic regions mediating verapamil hyper- and hypothermia in the cat.

Journal Article Brain Res Bull · August 1986 Guide cannulae for microinjection and push-pull perfusion in the unrestrained cat were implanted bilaterally in the anterior hypothalamic, preoptic area (AH/POA) and posterior hypothalamus (PH). Postoperatively, the region was first identified in AH/POA wh ... Full text Link to item Cite

Central Ca++-channel blockade reverses ethanol-induced poikilothermia in the rat.

Journal Article Alcohol · 1986 Two series of experiments were performed to determine the possible involvement of Ca++ channels in the thermolytic action of ethanol administered at a room temperature of 22 degrees C. In one group of 11 adult female Sprague-Dawley rats, stainless steel gu ... Full text Link to item Cite

alpha-Melanocyte-stimulating hormone infused ICV fails to affect body temperature or endotoxin fever in the cat.

Journal Article Brain Res Bull · January 1986 Permanent cannulae for intracerebroventricular (ICV) infusion were implanted bilaterally in cats following stereotaxic procedures. After colonic temperature was recorded for a one-hour baseline, a 300 microliter ICV infusion was given of CSF control vehicl ... Full text Link to item Cite

Divergent action of verapamil perfused in two hypothalamic areas on body temperature of the cat.

Journal Article Neurosci Lett · June 24, 1985 Guide cannulae for push-pull perfusion were bilaterally implanted stereotaxically within the anterior hypothalamic, preoptic area (AH/POA) and posterior hypothalamus (PH) of the cat. Catecholamine-reactive sites were identified within AH/POA in which a mic ... Full text Link to item Cite

New double-lumen polyethylene cannula for push-pull perfusion of brain tissue in vivo.

Journal Article J Neurosci Methods · January 1985 A new concept in the design of a push-pull cannula device for localized perfusion of brain tissue in the conscious and/or unrestrained animal is described. A catheter, consisting of a single strand of polyethylene tubing, contains an internal dividing sept ... Full text Link to item Cite

Reduced thermal sensitivity in the rabbit by beta-endorphin injection into the preoptic/anterior hypothalamus.

Journal Article Brain Res · February 6, 1984 Male New Zealand White rabbits, Oryctolagus cuniculus, were stereotaxically implanted with a guide tube above the preoptic/anterior hypothalamus (PO/AH) for the injection of beta-endorphin (beta-E) or saline at ambient temperatures of 20 and 25 degrees C. ... Full text Link to item Cite

Role of beta-endorphin in the control of body temperature in the rabbit.

Journal Article Neurosci Biobehav Rev · 1984 There is evidence of release of the opioid peptide beta-endorphin (beta-E) in the hypothalamus during development of fever and stress-induced hyperthermia. In the unanesthetized rabbit, microinjection of beta-E in the preoptic/anterior hypothalamus (POAH) ... Full text Link to item Cite

Action of preoptic injections of beta-endorphin on temperature regulation in rabbits.

Journal Article Am J Physiol · July 1982 Male New Zealand White rabbits, Oryctolagus cuniculus, were stereotaxically implanted with a guide tube above the preoptic/anterior hypothalamus area (PO/AH) for the injection of the opioid peptide, beta-endorphin (beta-E), naloxone, sodium salicylate, or ... Full text Link to item Cite

Action of preoptic injections of β-endorphin on temperature regulation in rabbits

Journal Article American Journal of Physiology - Regulatory Integrative and Comparative Physiology · January 1, 1982 Male New Zealand White rabbits, Oryctolagus cuniculus, were stereotaxically implanted with a guide tube above the preoptic/anterior hypothalamus area (PO/AH) for the injection of the opioid peptide, β-endorphin (β-E), naloxone, sodium salicylate, or physio ... Cite

Rapid brain cooling in the free-running hamster Mesocricetus auratus.

Journal Article J Appl Physiol Respir Environ Exerc Physiol · November 1981 A thermocouple reentrant tube was stereotaxically implanted in the rostral brain stem of the golden hamster, Mesocricetus auratus. Brain temperature was continuously recorded while the hamster was permitted volitional running on an activity wheel. There wa ... Full text Link to item Cite