Journal ArticleEpilepsia · October 9, 2025
OBJECTIVE: This study was undertaken to develop a framework for focal cortical dysplasia (FCD) detection using surface-based morphometric (SBM) analysis and machine learning (ML) applied to three-dimensional (3D) magnetic resonance fingerprinting (MRF). ME ...
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Journal ArticleJ Appl Clin Med Phys · July 2025
BACKGROUND: SyntheticMR has the capability of generating quantitative relaxometry maps and synthetic contrast-weighted MRI images in rapid acquisition times. Recently, it has gained attention in the diagnostic community, however, no studies have investigat ...
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Journal ArticlemedRxiv · April 10, 2025
OBJECTIVE: The purpose of this study was to optimize the technical tradeoffs associated with integrating the quantitative maps available from SyntheticMR into the head and neck adaptive radiation oncology workflow. Recent work has begun to investigate Synt ...
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Journal ArticleMagn Reson Med · February 2025
PURPOSE: To harmonize the use of color for MR relaxometry maps and therefore recommend the use of specific color-maps for representing T 1 $$ {\mathrm{T}}_1 $$ , T 2 $$ {\mathrm{T}}_2 $$ , and T 2 * $$ {\mathrm{T}}_2^{\ast } $$ maps and their i ...
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Journal ArticleMagn Reson Med · January 2025
PURPOSE: Quantitative MRI enables direct quantification of contrast agent concentrations in contrast-enhanced scans. However, the lengthy scan times required by conventional methods are inadequate for tracking contrast agent transport dynamically in mouse ...
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Journal ArticleAnn Neurol · November 2024
OBJECTIVE: To develop a multiparametric machine-learning (ML) framework using high-resolution 3 dimensional (3D) magnetic resonance (MR) fingerprinting (MRF) data for quantitative characterization of focal cortical dysplasia (FCD). MATERIALS: We included 1 ...
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Journal ArticleMagn Reson Med · October 2024
PURPOSE: For effective optimization of MR fingerprinting (MRF) pulse sequences, estimating and minimizing errors from actual scan conditions are crucial. Although virtual-scan simulations offer an approximation to these errors, their computational demands ...
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Journal ArticlemedRxiv · September 30, 2024
OBJECTIVE: The purpose of this study was to investigate the technical feasibility of integrating the quantitative maps available from SyntheticMR into the head and neck adaptive radiation oncology workflow. While SyntheticMR has been investigated for diagn ...
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Journal ArticleMagn Reson Med · September 2024
PURPOSE: T1 mapping is a widely used quantitative MRI technique, but its tissue-specific values remain inconsistent across protocols, sites, and vendors. The ISMRM Reproducible Research and Quantitative MR study groups jointly launched a challenge to asses ...
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Journal ArticleEpilepsia · June 2024
OBJECTIVE: We aim to improve focal cortical dysplasia (FCD) detection by combining high-resolution, three-dimensional (3D) magnetic resonance fingerprinting (MRF) with voxel-based morphometric magnetic resonance imaging (MRI) analysis. METHODS: We included ...
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Journal ArticleMagn Reson Med · May 2024
PURPOSE: Quantitative MRI techniques such as MR fingerprinting (MRF) promise more objective and comparable measurements of tissue properties at the point-of-care than weighted imaging. However, few direct cross-modal comparisons of MRF's repeatability and ...
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Journal ArticleMagn Reson Med · May 2024
PURPOSE: To propose a new reconstruction method for multidimensional MR fingerprinting (mdMRF) to address shading artifacts caused by physiological motion-induced measurement errors without navigating or gating. METHODS: The proposed method comprises two p ...
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Journal ArticleJ Magn Reson Imaging · May 2024
PURPOSE: To explore whether MR fingerprinting (MRF) scans provide motion-robust and quantitative brain tissue measurements for non-sedated infants with prenatal opioid exposure (POE). STUDY TYPE: Prospective. POPULATION: 13 infants with POE (3 male; 12 new ...
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Journal ArticleCereb Cortex · March 21, 2023
Quantitative magnetic resonance (MR) has been used to study cyto- and myelo-architecture of the human brain non-invasively. However, analyzing brain cortex using high-resolution quantitative MR acquisition can be challenging to perform using 3T clinical sc ...
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Journal ArticleMagn Reson Med · November 2022
PURPOSE: Although both relaxation and diffusion imaging are sensitive to tissue microstructure, studies have reported limited sensitivity and robustness of using relaxation or conventional diffusion alone to characterize tissue microstructure. Recently, it ...
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Journal ArticleMed Phys · April 2022
Magnetic resonance fingerprinting (MRF) is an emerging imaging technique for rapid and simultaneous quantification of multiple tissue properties. The technique has been developed for quantitative imaging of different organs. The obtained quantitative measu ...
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Journal ArticleNMR Biomed · April 2022
Quantitative mapping of MR tissue parameters such as the spin-lattice relaxation time (T1 ), the spin-spin relaxation time (T2 ), and the spin-lattice relaxation in the rotating frame (T1ρ ), referred to as MR relaxometry in general, has demonstrated impro ...
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Journal ArticleMagn Reson Med · March 2022
On behalf of the International Society for Magnetic Resonance in Medicine (ISMRM) Quantitative MR Study Group, this article provides an overview of considerations for the development, validation, qualification, and dissemination of quantitative MR (qMR) me ...
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Journal ArticleEur J Nucl Med Mol Imaging · December 2021
Magnetic resonance fingerprinting (MRF) is an evolving quantitative MRI framework consisting of unique data acquisition, processing, visualization, and interpretation steps. MRF is capable of simultaneously producing multiple high-resolution property maps ...
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Journal ArticleProc Natl Acad Sci U S A · October 5, 2021
Magnetic resonance fingerprinting (MRF) is a method to extract quantitative tissue properties such as [Formula: see text] and [Formula: see text] relaxation rates from arbitrary pulse sequences using conventional MRI hardware. MRF pulse sequences have thou ...
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Journal ArticleRadiology · August 2021
Background MR fingerprinting (MRF) provides rapid and simultaneous quantification of multiple tissue parameters in a single scan. Purpose To evaluate a rapid kidney MRF technique at 3.0 T in phantoms, healthy volunteers, and patients. Materials and Methods ...
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Journal ArticleMagn Reson Med · April 2021
PURPOSE: To implement 3D magnetic resonance fingerprinting (MRF) with quadratic RF phase (qRF-MRF) for simultaneous quantification of T1 , T2 , ΔB0 , and T2∗ . METHODS: 3D MRF data with effective undersampling factor of 3 in the slice direction were acquir ...
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Journal ArticleEur J Nucl Med Mol Imaging · March 2021
PURPOSE: This is a radiomics study investigating the ability of texture analysis of MRF maps to improve differentiation between intra-axial adult brain tumors and to predict survival in the glioblastoma cohort. METHODS: Magnetic resonance fingerprinting (M ...
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Journal ArticlePediatr Res · January 2021
BACKGROUND: Autosomal recessive polycystic kidney disease (ARPKD) is a rare but potentially lethal genetic disorder typically characterized by diffuse renal microcysts. Clinical trials for patients with ARPKD are not currently possible due to the absence o ...
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Journal ArticleMol Imaging Biol · December 2020
PURPOSE: Oral squamous cell carcinoma (OSCC) has not seen a substantial improvement in patient survival despite therapeutic advances, making accurate detection and characterization of the disease a clinical priority. Here, we aim to demonstrate the effecti ...
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Journal ArticleJ Magn Reson Imaging · April 2020
Magnetic resonance fingerprinting (MRF) is a general framework to quantify multiple MR-sensitive tissue properties with a single acquisition. There have been numerous advances in MRF in the years since its inception. In this work we highlight some of the r ...
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Journal ArticleJ Magn Reson Imaging · March 2020
Magnetic resonance fingerprinting (MRF) is a powerful quantitative MRI technique capable of acquiring multiple property maps simultaneously in a short timeframe. The MRF framework has been adapted to a wide variety of clinical applications, but faces chall ...
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Journal ArticleRadiology · August 2019
Background Only sparse literature investigates the reproducibility and repeatability of relaxometry methods in MRI. However, statistical data on reproducibility and repeatability of any quantitative method is essential for clinical application. Purpose To ...
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Journal ArticleNMR Biomed · May 2019
Magnetic resonance fingerprinting (MRF) is a quantitative imaging technique that maps multiple tissue properties through pseudorandom signal excitation and dictionary-based reconstruction. The aim of this study is to estimate and validate partial volumes f ...
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Journal ArticleJ Magn Reson Imaging · May 2019
BACKGROUND: Conventional MRI can be limited in detecting subtle epileptic lesions or identifying active/epileptic lesions among widespread, multifocal lesions. PURPOSE: We developed a high-resolution 3D MR fingerprinting (MRF) protocol to simultaneously pr ...
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Journal ArticleMagn Reson Med · April 2019
PURPOSE: To develop and evaluate the magnetic resonance field fingerprinting method that simultaneously generates T1 , T2 , B0 , and B 1 + maps from a single continuous measurement. METHODS: An encoding pattern was designed to integrate true fast imaging ...
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Journal ArticleIEEE Trans Med Imaging · March 2019
Magnetic resonance (MR) fingerprinting is a new quantitative imaging paradigm, which simultaneously acquires multiple MR tissue parameter maps in a single experiment. In this paper, we present an estimation-theoretic framework to perform experiment design ...
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Journal ArticleNMR Biomed · February 2019
This study introduces a technique for simultaneous multislice (SMS) cardiac magnetic resonance fingerprinting (cMRF), which improves the slice coverage when quantifying myocardial T1, T2 , and M0 . The single-slice cMRF pulse sequence was modified to use m ...
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Journal ArticleRadiology · January 2019
Purpose To develop a fast three-dimensional method for simultaneous T1 and T2 quantification for breast imaging by using MR fingerprinting. Materials and Methods In this prospective study, variable flip angles and magnetization preparation modules were app ...
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Journal ArticleMagn Reson Med · January 2019
Multiparametric quantitative imaging is gaining increasing interest due to its widespread advantages in clinical applications. Magnetic resonance fingerprinting is a recently introduced approach of fast multiparametric quantitative imaging. In this article ...
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Journal ArticlePediatr Neurosurg · 2019
OBJECT: Magnetic resonance fingerprinting (MRF) allows rapid, simultaneous mapping of T1 and T2 relaxation times and may be an important diagnostic tool to measure tissue characteristics in pediatric brain tumors. We examined children and young adults with ...
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Journal ArticleMagn Reson Med · December 2018
PURPOSE: The purpose of this study is to increase the robustness of MR fingerprinting (MRF) toward subject motion. METHODS: A novel reconstruction algorithm, MOtion insensitive MRF (MORF), was developed, which uses an iterative reconstruction based retrosp ...
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Journal ArticleMagn Reson Med · December 2018
PURPOSE: The goal of this study was to develop a fast MR fingerprinting (MRF) method for simultaneous T1 and T2 mapping in DCE-MRI studies in mice. METHODS: The MRF sequences based on balanced SSFP and fast imaging with steady-state precession were impleme ...
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Journal ArticleMagn Reson Imaging · November 2018
This study aims to improve the accuracy and consistency of T1 and T2 measurements using cardiac MR Fingerprinting (cMRF) by investigating and accounting for the effects of confounding factors including slice profile, inversion and T2 preparation pulse effi ...
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Journal ArticleMagn Reson Imaging · July 2018
In this study, the acquisition of ASL data and quantification of multiple hemodynamic parameters was explored using a Magnetic Resonance Fingerprinting (MRF) approach. A pseudo-continuous ASL labeling scheme was used with pseudo-randomized timings to acqui ...
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Journal ArticleMagn Reson Med · July 2018
PURPOSE: To estimate multiple components within a single voxel in magnetic resonance fingerprinting when the number and types of tissues comprising the voxel are not known a priori. THEORY: Multiple tissue components within a single voxel are potentially s ...
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Journal ArticleMagn Reson Med · April 2018
PURPOSE: This work proposes new low rank approximation approaches with significant memory savings for large scale MR fingerprinting (MRF) problems. THEORY AND METHODS: We introduce a compressed MRF with randomized singular value decomposition method to sig ...
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Journal ArticleMagn Reson Med · April 2018
PURPOSE: The purpose of this study was to accelerate the acquisition and reconstruction time of 3D magnetic resonance fingerprinting scans. METHODS: A 3D magnetic resonance fingerprinting scan was accelerated by using a single-shot spiral trajectory with a ...
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Journal ArticleMagn Reson Med · February 2018
PURPOSE: This article introduces a constrained imaging method based on low-rank and subspace modeling to improve the accuracy and speed of MR fingerprinting (MRF). THEORY AND METHODS: A new model-based imaging method is developed for MRF to reconstruct hig ...
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Journal ArticleMagn Reson Med · November 2017
PURPOSE: The purpose of this study is to accelerate an MR fingerprinting (MRF) acquisition by using a simultaneous multislice method. METHODS: A multiband radiofrequency (RF) pulse was designed to excite two slices with different flip angles and phases. Th ...
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Journal ArticleMagn Reson Med · November 2017
PURPOSE: The goal of this study is to characterize and improve the accuracy of 2D magnetic resonance fingerprinting (MRF) scans in the presence of slice profile (SP) and B1 imperfections, which are two main factors that affect quantitative results in MRF. ...
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Journal ArticleMagn Reson Med · October 2017
PURPOSE: The purpose of this study was to evaluate accuracy and repeatability of T1 and T2 estimates of a MR fingerprinting (MRF) method using the ISMRM/NIST MRI system phantom. METHODS: The ISMRM/NIST MRI system phantom contains multiple compartments with ...
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Journal ArticleCurr Opin Biomed Eng · September 2017
Magnetic Resonance Fingerprinting (MRF) is a new approach to quantitative magnetic resonance imaging that allows simultaneous measurement of multiple tissue properties in a single, time-efficient acquisition. The ability to reproducibly and quantitatively ...
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Journal ArticleMagn Reson Med · May 2017
PURPOSE: To develop a reconstruction method to improve SMS-MRF, in which slice acceleration is used in conjunction with highly undersampled in-plane acceleration to speed up MRF acquisition. METHODS: In this work two methods are employed to efficiently per ...
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Journal ArticleMagnetic Resonance in Medicine · April 1, 2017
Purpose: To introduce a two-dimensional MR fingerprinting (MRF) technique for quantification of T1, T2, and M0 in myocardium. Methods: An electrocardiograph-triggered MRF method is introduced for mapping myocardial T1< ...
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Journal ArticleMagn Reson Med · April 2017
PURPOSE: To introduce a two-dimensional MR fingerprinting (MRF) technique for quantification of T1 , T2 , and M0 in myocardium. METHODS: An electrocardiograph-triggered MRF method is introduced for mapping myocardial T1 , T2 , and M0 during a single breath ...
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Journal ArticleMagn Reson Med · March 2017
PURPOSE: The purpose of the study is to develop a quantitative method for the relaxation properties with a reduced radio frequency (RF) power deposition by combining magnetic resonance fingerprinting (MRF) technique with quick echo splitting NMR imaging te ...
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Journal ArticleAJNR Am J Neuroradiol · March 2017
BACKGROUND AND PURPOSE: MR fingerprinting allows rapid simultaneous quantification of T1 and T2 relaxation times. This study assessed the utility of MR fingerprinting in differentiating common types of adult intra-axial brain tumors. MATERIALS AND METHODS: ...
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Journal ArticleMagn Reson Med · June 2016
PURPOSE: Unpleasant acoustic noise is a drawback of almost every MRI scan. Instead of reducing acoustic noise to improve patient comfort, we propose a technique for mitigating the noise problem by producing musical sounds directly from the switching magnet ...
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Journal ArticleMagn Reson Med · June 2016
PURPOSE: To reduce the acquisition time needed to obtain reliable parametric maps with Magnetic Resonance Fingerprinting. METHODS: An iterative-denoising algorithm is initialized by reconstructing the MRF image series at low image resolution. For subsequen ...
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Journal ArticleMagn Reson Med · May 2016
PURPOSE: We incorporate simultaneous multislice (SMS) acquisition into MR fingerprinting (MRF) to accelerate the MRF acquisition. METHODS: The t-Blipped SMS-MRF method is achieved by adding a Gz blip before each data acquisition window and balancing it wit ...
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Journal ArticleRadiology · April 2016
PURPOSE: To develop a magnetic resonance (MR) "fingerprinting" technique for quantitative abdominal imaging. MATERIALS AND METHODS: This HIPAA-compliant study had institutional review board approval, and informed consent was obtained from all subjects. To ...
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Journal ArticleMagn Reson Med · December 2015
PURPOSE: This study explores the possibility of using gradient echo-based sequences other than balanced steady-state free precession (bSSFP) in the magnetic resonance fingerprinting (MRF) framework to quantify the relaxation parameters . METHODS: An MRF me ...
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Journal ArticleMagn Reson Med · August 2015
PURPOSE: MR fingerprinting (MRF) is a technique for quantitative tissue mapping using pseudorandom measurements. To estimate tissue properties such as T1 , T2 , proton density, and B0 , the rapidly acquired data are compared against a large dictionary of B ...
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Journal ArticleNMR Biomed · March 2015
High-field preclinical MRI scanners are now commonly used to quantitatively assess disease status and the efficacy of novel therapies in a wide variety of rodent models. Unfortunately, conventional MRI methods are highly susceptible to respiratory and card ...
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Journal ArticleIEEE Trans Med Imaging · December 2014
Magnetic resonance (MR) fingerprinting is a technique for acquiring and processing MR data that simultaneously provides quantitative maps of different tissue parameters through a pattern recognition algorithm. A predefined dictionary models the possible si ...
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Journal ArticleJ Cardiovasc Magn Reson · September 11, 2014
BACKGROUND: The standard clinical acquisition for left ventricular functional parameter analysis with cardiovascular magnetic resonance (CMR) uses a multi-breathhold multi-slice segmented balanced SSFP sequence. Performing multiple long breathholds in quic ...
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Journal ArticleNature · March 14, 2013
Magnetic resonance is an exceptionally powerful and versatile measurement technique. The basic structure of a magnetic resonance experiment has remained largely unchanged for almost 50 years, being mainly restricted to the qualitative probing of only a lim ...
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Journal ArticleIEEE Trans Nucl Sci · February 2013
Stationary small-animal SPECT systems are being developed for rapid dynamic imaging from limited angular views. This paper quantified, through simulations, the performance of Maximum Likelihood Expectation Maximization (MLEM) for reconstructing a time-acti ...
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Journal ArticleMagn Reson Med · January 2013
A promising approach for the simultaneous quantification of relative proton density (M(0)), T(1), and T(2) is the inversion-recovery TrueFISP sequence, consisting of an inversion pulse followed by a series of balanced steady-state free precession acquisiti ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · December 1, 2010
This work optimized a multi-pinhole collimator for a stationary three-camera Single Photon Emission Computed Tomography (SPECT) system designed for rapid (one-second) dynamic imaging through simulations. Multi-pinhole collimator designs were investigated t ...
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